Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MYL060 MIFTS: 32	Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases
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Aliases & Classifications for Myeloid and Lymphoid Neoplasms Associated with Pdgfra...

MalaCards integrated aliases for Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement:

Name: Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement ¹² ¹⁵

Myeloid/lymphoid Neoplasm Associated with Pdgfra Rearrangement ⁵⁸

Myeloid and Lymphoid Neoplasms with Pdgfra Rearrangement ¹²

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Blood diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Neoplasms

Neoplasms of uncertain or unknown behaviour

Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue

Chronic myeloproliferative disease

Orphanet: ⁵⁸

Rare haematological diseases

External Ids:

Disease Ontology ¹² DOID:0080165

NCIt ⁴⁹ C84275

ICD10 via Orphanet ³³ D47.1

Orphanet ⁵⁸ ORPHA168947

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Summaries for Myeloid and Lymphoid Neoplasms Associated with Pdgfra...

Disease Ontology : ¹² A myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1 that is characterized by the rearrangement of the PDGFRA gene, most often resulting in the formation of FIP1L1-PDGFRA fusion transcripts.

MalaCards based summary : Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement, also known as myeloid/lymphoid neoplasm associated with pdgfra rearrangement, is related to pdgfra-associated chronic eosinophilic leukemia and loeffler endocarditis. An important gene associated with Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement is PDGFRA (Platelet Derived Growth Factor Receptor Alpha), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. Affiliated tissues include myeloid, bone and bone marrow, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Myeloid and Lymphoid Neoplasms Associated with Pdgfra...

Diseases related to Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)

#	Related Disease	Score	Top Affiliating Genes
1	pdgfra-associated chronic eosinophilic leukemia	10.4	PDGFRA FIP1L1
2	loeffler endocarditis	10.4	PDGFRA FIP1L1
3	cerebellar angioblastoma	10.3	PDGFRA ETV6
4	myeloproliferative disorder, chronic, with eosinophilia	10.3	PDGFRB ETV6
5	reticular perineurioma	10.2	PDGFRA KIT
6	perineurioma	10.2	PDGFRA KIT
7	deep leiomyoma	10.2	PDGFRA KIT
8	heart leiomyosarcoma	10.2	PDGFRA KIT
9	small intestine leiomyoma	10.2	PDGFRA KIT
10	gastric leiomyoma	10.2	PDGFRA KIT
11	disseminated eosinophilic collagen disease	10.2	PDGFRA FIP1L1 CHIC2
12	pulmonary vein stenosis	10.2	PDGFRA KIT
13	gastric leiomyosarcoma	10.2	PDGFRA KIT
14	extracutaneous mastocytoma	10.2	KIT FIP1L1
15	endometrial small cell carcinoma	10.2	PDGFRA KIT
16	fibrosarcoma of bone	10.2	PDGFRA KIT
17	testicular leukemia	10.2	ETV6 ABL1
18	undifferentiated pleomorphic sarcoma	10.2	PDGFRA KIT
19	mast-cell sarcoma	10.2	KIT FIP1L1
20	uterus leiomyosarcoma	10.2	PDGFRA KIT
21	conventional fibrosarcoma	10.2	PDGFRA KIT
22	carney triad	10.1	PDGFRA KIT
23	acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	10.1	KIT ETV6
24	neurofibromatosis, type i	10.1	PDGFRA KIT
25	sarcomatoid renal cell carcinoma	10.1	PDGFRA KIT
26	chondroma	10.1	PDGFRA KIT
27	myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1	10.1	PDGFRB PDGFRA FGFR1
28	adult mesoblastic nephroma	10.1	KIT ETV6
29	leukemia, acute lymphoblastic 3	10.0	PDGFRA ETV6 ABL1
30	aggressive systemic mastocytosis	10.0	PDGFRA KIT FIP1L1
31	mastocytosis, cutaneous	10.0	PDGFRA KIT FIP1L1
32	pleomorphic liposarcoma	10.0	PDGFRA KIT
33	mesenchymal cell neoplasm	10.0	PDGFRB PDGFRA KIT
34	desmoid tumor	10.0	PDGFRB PDGFRA KIT
35	ocular melanoma	10.0	PDGFRB PDGFRA KIT
36	neurilemmoma	10.0	PDGFRB PDGFRA KIT
37	indolent systemic mastocytosis	10.0	KIT FIP1L1
38	endomyocardial fibrosis	9.9	PDGFRB PDGFRA FIP1L1 CHIC2
39	leiomyosarcoma	9.9	PDGFRB PDGFRA KIT
40	retinitis pigmentosa and erythrocytic microcytosis	9.9	JAK2 EPO
41	budd-chiari syndrome	9.9	PDGFRA JAK2 FIP1L1
42	acquired polycythemia	9.9	JAK2 EPO
43	core binding factor acute myeloid leukemia	9.9	KIT JAK2
44	malignant peripheral nerve sheath tumor	9.9	PDGFRB PDGFRA KIT
45	congenital mesoblastic nephroma	9.9	KIT ETV6
46	8p11 myeloproliferative syndrome	9.9	PDGFRB KIT FGFR1
47	infantile myofibromatosis	9.9	PDGFRB ETV6
48	endometrial stromal sarcoma	9.8	PDGFRB PDGFRA KIT
49	salivary gland carcinoma	9.8	KIT FGFR1 ETV6
50	splenomegaly	9.8	JAK2 EPO

Graphical network of the top 20 diseases related to Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement:

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Symptoms & Phenotypes for Myeloid and Lymphoid Neoplasms Associated with Pdgfra...

GenomeRNAi Phenotypes related to Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement according to GeneCards Suite gene sharing:

²⁶ (show all 15)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00173-A	10.02	PDGFRA
2	Decreased viability	GR00221-A-1	10.02	ABL1 FGFR1 KIT PDGFRA PDGFRB
3	Decreased viability	GR00221-A-2	10.02	ABL1 FGFR1
4	Decreased viability	GR00221-A-3	10.02	ABL1 PDGFRA PDGFRB
5	Decreased viability	GR00221-A-4	10.02	PDGFRA PDGFRB
6	Decreased viability	GR00301-A	10.02	KIT
7	Decreased viability	GR00342-S-1	10.02	ABL1 PDGFRB
8	Decreased viability	GR00342-S-2	10.02	ABL1
9	Decreased viability	GR00342-S-3	10.02	ABL1
10	Decreased viability	GR00402-S-2	10.02	ABL1 FGFR1 KIT PDGFRA PDGFRB
11	Decreased substrate adherent cell growth	GR00193-A-1	9.97	KIT
12	Decreased substrate adherent cell growth	GR00193-A-2	9.97	ABL1 JAK2 KIT
13	Decreased substrate adherent cell growth	GR00193-A-3	9.97	JAK2
14	Decreased substrate adherent cell growth	GR00193-A-4	9.97	ABL1 KIT FGFR1
15	Increased cell viability after pRB stimulation	GR00230-A-1	8.8	ABL1 KIT PDGFRB

MGI Mouse Phenotypes related to Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement:

⁴⁵ (show all 16)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.21	ABL1 CSF2 EPO ETV6 FGFR1 JAK2
2	cellular	MP:0005384	10.2	ABL1 CSF2 EPO ETV6 FGFR1 JAK2
3	embryo	MP:0005380	10.16	ABL1 CSF2 EPO ETV6 FGFR1 JAK2
4	hematopoietic system	MP:0005397	10.13	ABL1 CSF2 EPO ETV6 FGFR1 JAK2
5	homeostasis/metabolism	MP:0005376	10.11	ABL1 CSF2 EPO ETV6 FGFR1 JAK2
6	endocrine/exocrine gland	MP:0005379	10.1	ABL1 CSF2 ETV6 FGFR1 JAK2 KIT
7	integument	MP:0010771	10.1	CHIC2 CSF2 EPO ETV6 FGFR1 JAK2
8	immune system	MP:0005387	10.09	ABL1 CSF2 EPO ETV6 FGFR1 JAK2
9	mortality/aging	MP:0010768	10.07	ABL1 CHIC2 CSF2 EPO ETV6 FGFR1
10	craniofacial	MP:0005382	10.01	ABL1 CSF2 FGFR1 KIT PDGFRA PDGFRB
11	digestive/alimentary	MP:0005381	10	ABL1 ETV6 FGFR1 KIT PDGFRA PDGFRB
12	muscle	MP:0005369	9.8	ABL1 EPO FGFR1 KIT PDGFRA PDGFRB
13	normal	MP:0002873	9.76	ABL1 EPO ETV6 FGFR1 JAK2 KIT
14	neoplasm	MP:0002006	9.65	CSF2 ETV6 JAK2 KIT PDGFRA
15	respiratory system	MP:0005388	9.43	ABL1 CSF2 EPO JAK2 KIT PDGFRA
16	skeleton	MP:0005390	9.23	ABL1 CSF2 EPO FGFR1 JAK2 KIT

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Drugs & Therapeutics for Myeloid and Lymphoid Neoplasms Associated with Pdgfra...

Search Clinical Trials , NIH Clinical Center for Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement

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Genetic Tests for Myeloid and Lymphoid Neoplasms Associated with Pdgfra...

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Anatomical Context for Myeloid and Lymphoid Neoplasms Associated with Pdgfra...

MalaCards organs/tissues related to Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement:

⁴⁰

Myeloid, Bone, Bone Marrow, Heart, Small Intestine, Salivary Gland, Breast

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Publications for Myeloid and Lymphoid Neoplasms Associated with Pdgfra...

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Genes for Myeloid and Lymphoid Neoplasms Associated with Pdgfra...

Genes related to Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement (1 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	354.11	Gene fusion ⁵⁸ DISEASES inferred ¹⁵
2	CHIC2	Cysteine Rich Hydrophobic Domain 2	Protein Coding	5.74	DISEASES inferred ¹⁵
3	FIP1L1	Factor Interacting With PAPOLA And CPSF1	Protein Coding	5.02	DISEASES inferred ¹⁵
4	RARS1	Arginyl-TRNA Synthetase 1	Protein Coding	4.56	DISEASES inferred ¹⁵
5	ETV6	ETS Variant Transcription Factor 6	Protein Coding	4.54	DISEASES inferred ¹⁵
6	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	4.01	DISEASES inferred ¹⁵
7	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	3.96	DISEASES inferred ¹⁵
8	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	3.84	DISEASES inferred ¹⁵
9	EPO	Erythropoietin	Protein Coding	3.62	DISEASES inferred ¹⁵
10	JAK2	Janus Kinase 2	Protein Coding	3.6	DISEASES inferred ¹⁵
11	CSF2	Colony Stimulating Factor 2	Protein Coding	3.33	DISEASES inferred ¹⁵
12	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	3.3	DISEASES inferred ¹⁵

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Variations for Myeloid and Lymphoid Neoplasms Associated with Pdgfra...

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Expression for Myeloid and Lymphoid Neoplasms Associated with Pdgfra...

Search GEO for disease gene expression data for Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement.

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Pathways for Myeloid and Lymphoid Neoplasms Associated with Pdgfra...

Pathways related to Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement according to GeneCards Suite gene sharing:

(show all 35)

#	Super pathways	Score	Top Affiliating Genes
1	ERK Signaling ⁶³ Show member pathways ILK Signaling ⁶³ MAPK Signaling ⁶³ Molecular Mechanisms of Cancer ⁶³ Rho Family GTPases ⁶³	13.65	PDGFRB PDGFRA KIT JAK2 FGFR1 CSF2
2	PEDF Induced Signaling ⁶³ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶³ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶³ Glucocorticoid Receptor Signaling ⁶³ IL-6 Pathway ⁶³ MIF Mediated Glucocorticoid Regulation ⁶³ MIF Regulation of Innate Immune Cells ⁶³ NFAT Signaling and Lymphocyte Interactions ⁶³ PGC1Alpha Pathway ⁶³ RAR-Gamma-RXR-Alpha Degradation ⁶³ STAT3 Pathway ⁶³	13.5	PDGFRB PDGFRA KIT JAK2 FGFR1 EPO
3	TGF-Beta Pathway ⁶³ Show member pathways JAK-STAT Pathway ⁶³ JNK Pathway ⁶³ MAPK Family Pathway ⁶³ Regulation of eIF4 and p70S6K ⁶³ SOCS Pathway ⁶³	13.38	PDGFRB PDGFRA KIT JAK2 FGFR1 EPO
4	Developmental Biology ⁶⁵ Show member pathways Axon guidance ⁶⁵	13.29	PDGFRB PDGFRA KIT JAK2 FGFR1 CSF2
5	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.24	PDGFRB PDGFRA KIT JAK2 FGFR1 CSF2
6	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.17	PDGFRB PDGFRA KIT JAK2 FGFR1 CSF2
7	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.1	PDGFRB PDGFRA KIT JAK2 FGFR1 CSF2
8	p70S6K Signaling ⁶³ Show member pathways mTOR Pathway ⁶³ Renin-Angiotensin Pathway ⁶³	12.88	PDGFRB PDGFRA KIT JAK2 FGFR1
9	Actin Nucleation by ARP-WASP Complex ⁶³ Show member pathways Actin Nucleation and Branching ⁶³ CDC42 Pathway ⁶³ RhoA Pathway ⁶³	12.8	PDGFRB PDGFRA KIT FGFR1
10	PI3K-Akt signaling pathway ³⁶ Show member pathways Human papillomavirus infection ³⁶	12.72	PDGFRB PDGFRA KIT JAK2 FGFR1 EPO
11	MAPK signaling pathway ³⁶ ¹	12.62	PDGFRB PDGFRA KIT FGFR1
12	Development Angiotensin activation of ERK ²² Show member pathways Cell adhesion Integrin inside-out signaling ²² Development ACM2 and ACM4 activation of ERK ²² Development Angiotensin signaling via PYK2 ²² Development EDNRB signaling ²² Development EPO-induced MAPK pathway ²² Development G-Proteins mediated regulation MARK-ERK signaling ²² Signal transduction IP3 signaling ²²	12.62	PDGFRB PDGFRA KIT JAK2 EPO
13	Endometrial cancer ³⁶ Show member pathways Acute myeloid leukemia ³⁶ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²² Thyroid cancer ³⁶	12.59	PDGFRB PDGFRA KIT FGFR1 CSF2 ABL1
14	Downstream signaling events of B Cell Receptor (BCR) ⁶⁵ Show member pathways Activation of RAS in B cells ⁶⁵ Signaling by the B Cell Receptor (BCR) ⁶⁵	12.58	PDGFRB PDGFRA KIT FGFR1
15	Ras signaling pathway ³⁶ Show member pathways Rap1 signaling pathway ³⁶	12.55	PDGFRB PDGFRA KIT FGFR1 ABL1
16	ErbB signaling pathway ¹ ³⁶ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ³⁶ Renal cell carcinoma ³⁶ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.46	PDGFRB PDGFRA JAK2 ABL1
17	G-protein signaling RAC1 in cellular process ²² Show member pathways CDC42 signaling events ¹ Cytoskeleton remodeling CDC42 in cellular processes ²² RAC1 signaling pathway ¹	12.26	PDGFRB PDGFRA KIT FGFR1
18	Pathways in cancer ³⁶	12.22	PDGFRB PDGFRA KIT JAK2 FGFR1 EPO
19	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	12.04	PDGFRB PDGFRA KIT FGFR1 ABL1
20	Kit receptor signaling pathway ¹ Show member pathways IL-3 Signaling Pathway ¹ Signaling events mediated by Stem cell factor receptor (c-Kit) ¹	12.03	KIT JAK2 EPO
21	JAK-STAT signaling pathway (KEGG) ³⁶ Show member pathways Interleukin-19, 20, 22, 24 ⁶⁵ Jak/STAT Signaling Pathway ⁶⁴	12.02	PDGFRB PDGFRA JAK2 EPO CSF2
22	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.87	KIT EPO CSF2
23	Jak-Stat Signaling Pathway (sino) ⁶⁶	11.76	JAK2 EPO ABL1
24	Hematopoietic cell lineage ³⁶	11.76	KIT EPO CSF2
25	Angiogenesis (CST) ⁴	11.7	PDGFRB PDGFRA FGFR1
26	VEGF Pathway (Tocris) ⁶⁰ Show member pathways VEGF Pathway ⁷⁰	11.66	PDGFRB KIT FGFR1
27	Central carbon metabolism in cancer ³⁶	11.46	PDGFRB PDGFRA KIT FGFR1
28	Alzheimers Disease Pathway ⁶³	11.35	PDGFRB PDGFRA FGFR1
29	Vemurafenib Pathway, Pharmacodynamics ⁶⁰	11.3	PDGFRB PDGFRA FGFR1
30	Tyrosine Kinases / Adaptors ⁴	11.27	PDGFRB PDGFRA KIT JAK2 FGFR1 ABL1
31	Pazopanib Pathway, Pharmacokinetics ⁶⁰ Show member pathways Sunitinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	11.18	PDGFRB PDGFRA KIT
32	Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Show member pathways Bosutinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Imatinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Nilotinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Taxane Pathway, Pharmacokinetics ⁶⁰	11.17	PDGFRB PDGFRA KIT ABL1
33	Cytoskeleton remodeling_Role of PDGFs in cell migration ²²	11.02	PDGFRB PDGFRA
34	G-protein signaling_Rap2B regulation pathway ²²	10.85	PDGFRB PDGFRA KIT FGFR1 CSF2
35	Osteoblast Signaling ¹	10.77	PDGFRB PDGFRA

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GO Terms for Myeloid and Lymphoid Neoplasms Associated with Pdgfra...

Cellular components related to Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	receptor complex	GO:0043235	8.92	PDGFRB PDGFRA KIT FGFR1

Biological processes related to Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement according to GeneCards Suite gene sharing:

(show all 34)

#	Name	GO ID	Score	Top Affiliating Genes
1	phosphorylation	GO:0016310	9.97	PDGFRB PDGFRA KIT JAK2 FGFR1 ABL1
2	positive regulation of cell proliferation	GO:0008284	9.95	PDGFRB PDGFRA KIT JAK2 FGFR1 EPO
3	protein phosphorylation	GO:0006468	9.93	PDGFRB PDGFRA KIT JAK2 FGFR1 ABL1
4	positive regulation of cell migration	GO:0030335	9.92	PDGFRB PDGFRA KIT JAK2
5	positive regulation of ERK1 and ERK2 cascade	GO:0070374	9.89	PDGFRB PDGFRA EPO ABL1
6	regulation of cell proliferation	GO:0042127	9.88	KIT FGFR1 CSF2 ABL1
7	positive regulation of protein kinase B signaling	GO:0051897	9.85	PDGFRB PDGFRA KIT FGFR1
8	positive regulation of cytosolic calcium ion concentration	GO:0007204	9.83	PDGFRA JAK2 ABL1
9	cell chemotaxis	GO:0060326	9.81	PDGFRB PDGFRA KIT
10	MAPK cascade	GO:0000165	9.8	PDGFRB PDGFRA KIT JAK2 FGFR1 CSF2
11	hematopoietic progenitor cell differentiation	GO:0002244	9.79	PDGFRB PDGFRA KIT
12	positive regulation of MAP kinase activity	GO:0043406	9.78	PDGFRB KIT FGFR1
13	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	9.78	PDGFRB PDGFRA KIT FGFR1
14	phosphatidylinositol-mediated signaling	GO:0048015	9.76	PDGFRB PDGFRA FGFR1
15	erythrocyte differentiation	GO:0030218	9.73	KIT JAK2 EPO
16	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.73	KIT JAK2 EPO CSF2
17	protein autophosphorylation	GO:0046777	9.73	PDGFRB PDGFRA KIT JAK2 FGFR1 ABL1
18	positive regulation of phosphatidylinositol 3-kinase activity	GO:0043552	9.69	PDGFRB PDGFRA KIT
19	platelet-derived growth factor receptor signaling pathway	GO:0048008	9.67	PDGFRB PDGFRA JAK2 ABL1
20	positive regulation of Ras protein signal transduction	GO:0046579	9.66	JAK2 EPO
21	regulation of actin cytoskeleton reorganization	GO:2000249	9.65	PDGFRA ABL1
22	response to hyperoxia	GO:0055093	9.65	PDGFRB EPO
23	cardiac myofibril assembly	GO:0055003	9.65	PDGFRB PDGFRA
24	positive regulation of phosphoprotein phosphatase activity	GO:0032516	9.64	PDGFRB JAK2
25	negative regulation of cell-cell adhesion	GO:0022408	9.64	JAK2 ABL1
26	response to fluid shear stress	GO:0034405	9.63	PDGFRB CSF2
27	retina vasculature development in camera-type eye	GO:0061298	9.62	PDGFRB PDGFRA
28	platelet-derived growth factor receptor-beta signaling pathway	GO:0035791	9.6	PDGFRB ABL1
29	erythropoietin-mediated signaling pathway	GO:0038162	9.57	KIT EPO
30	metanephric glomerular capillary formation	GO:0072277	9.54	PDGFRB PDGFRA
31	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	GO:0038091	9.52	PDGFRB PDGFRA
32	positive regulation of phospholipase C activity	GO:0010863	9.46	PDGFRB PDGFRA KIT FGFR1
33	peptidyl-tyrosine phosphorylation	GO:0018108	9.43	PDGFRB PDGFRA KIT JAK2 FGFR1 ABL1
34	positive regulation of phosphatidylinositol 3-kinase signaling	GO:0014068	9.1	PDGFRB PDGFRA KIT JAK2 FGFR1 EPO

Molecular functions related to Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement according to GeneCards Suite gene sharing:

(show all 13)

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	10.27	RARS1 PDGFRB PDGFRA KIT JAK2 FIP1L1
2	transferase activity	GO:0016740	10	PDGFRB PDGFRA KIT JAK2 FGFR1 ABL1
3	ATP binding	GO:0005524	9.95	RARS1 PDGFRB PDGFRA KIT JAK2 FGFR1
4	kinase activity	GO:0016301	9.85	PDGFRB PDGFRA KIT JAK2 FGFR1 ABL1
5	protein kinase activity	GO:0004672	9.8	PDGFRB PDGFRA KIT JAK2 FGFR1 ABL1
6	nucleotide binding	GO:0000166	9.73	RARS1 PDGFRB PDGFRA KIT JAK2 FGFR1
7	phosphatidylinositol 3-kinase binding	GO:0043548	9.51	PDGFRB JAK2
8	platelet-derived growth factor receptor binding	GO:0005161	9.48	PDGFRB PDGFRA
9	platelet-derived growth factor binding	GO:0048407	9.46	PDGFRB PDGFRA
10	transmembrane receptor protein tyrosine kinase activity	GO:0004714	9.46	PDGFRB PDGFRA KIT FGFR1
11	vascular endothelial growth factor binding	GO:0038085	9.43	PDGFRB PDGFRA
12	SH2 domain binding	GO:0042169	9.26	KIT JAK2 FGFR1 ABL1
13	protein tyrosine kinase activity	GO:0004713	9.1	PDGFRB PDGFRA KIT JAK2 FGFR1 ABL1

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