Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MYL060 MIFTS: 30	Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases
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Aliases & Classifications for Myeloid and Lymphoid Neoplasms Associated with Pdgfra...

MalaCards integrated aliases for Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement:

Name: Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement ¹² ¹⁵

Myeloid/lymphoid Neoplasm Associated with Pdgfra Rearrangement ⁵⁸

Myeloid and Lymphoid Neoplasms with Pdgfra Rearrangement ¹²

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Blood diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Neoplasms

Neoplasms of uncertain or unknown behaviour

Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue

Chronic myeloproliferative disease

Orphanet: ⁵⁸

Rare haematological diseases

External Ids:

Disease Ontology ¹² DOID:0080165

NCIt ⁴⁹ C84275

ICD10 via Orphanet ³³ D47.1

Orphanet ⁵⁸ ORPHA168947

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Summaries for Myeloid and Lymphoid Neoplasms Associated with Pdgfra...

Disease Ontology : ¹² A myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1 that is characterized by the rearrangement of the PDGFRA gene, most often resulting in the formation of FIP1L1-PDGFRA fusion transcripts.

MalaCards based summary : Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement, also known as myeloid/lymphoid neoplasm associated with pdgfra rearrangement, is related to pdgfra-associated chronic eosinophilic leukemia and reticular perineurioma. An important gene associated with Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement is PDGFRA (Platelet Derived Growth Factor Receptor Alpha), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. Affiliated tissues include myeloid, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

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Related Diseases for Myeloid and Lymphoid Neoplasms Associated with Pdgfra...

Diseases related to Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)

#	Related Disease	Score	Top Affiliating Genes
1	pdgfra-associated chronic eosinophilic leukemia	10.4	PDGFRA FIP1L1
2	reticular perineurioma	10.2	PDGFRA KIT
3	perineurioma	10.2	PDGFRA KIT
4	small intestinal sarcoma	10.2	PDGFRA KIT
5	deep leiomyoma	10.2	PDGFRA KIT
6	gastric leiomyoma	10.2	PDGFRA KIT
7	pulmonary vein stenosis	10.2	PDGFRA KIT
8	laryngeal small cell carcinoma	10.2	PDGFRA KIT
9	gastric leiomyosarcoma	10.2	PDGFRA KIT
10	disseminated eosinophilic collagen disease	10.2	PDGFRA FIP1L1 CHIC2
11	colon leiomyosarcoma	10.2	PDGFRA KIT
12	small intestine leiomyoma	10.2	PDGFRA KIT
13	extracutaneous mastocytoma	10.2	KIT FIP1L1
14	myofibroma	10.2	PDGFRB ETV6
15	b-lymphoblastic leukemia/lymphoma with hypodiploidy	10.2	ETV6 ABL1
16	endometrial small cell carcinoma	10.2	PDGFRA KIT
17	loeffler endocarditis	10.2	PDGFRA FIP1L1 ETV6
18	testicular leukemia	10.2	ETV6 ABL1
19	mast-cell sarcoma	10.2	KIT FIP1L1
20	carney triad	10.2	PDGFRA KIT
21	b-lymphoblastic leukemia/lymphoma with iamp21	10.2	ETV6 ABL1
22	b-lymphoblastic leukemia/lymphoma with hyperdiploidy	10.1	ETV6 ABL1
23	conventional fibrosarcoma	10.1	PDGFRA KIT
24	acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	10.1	KIT ETV6
25	b-lymphoblastic leukemia/lymphoma	10.1	KIT FGFR1
26	fibrosarcoma of bone	10.1	PDGFRA KIT
27	chondroma	10.1	PDGFRA KIT
28	sarcomatous intrahepatic cholangiocarcinoma	10.1	PDGFRB KIT
29	myeloproliferative disorder, chronic, with eosinophilia	10.1	PDGFRB FIP1L1 ETV6
30	myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1	10.1	PDGFRB PDGFRA FGFR1
31	pleomorphic liposarcoma	10.1	PDGFRA KIT
32	brain stem glioma	10.0	PDGFRB PDGFRA FGFR1
33	leukemia, acute lymphoblastic 3	10.0	PDGFRA ETV6 ABL1
34	b-lymphoblastic leukemia/lymphoma, bcr-abl1-like	10.0	JAK2 ABL1
35	kidney benign neoplasm	10.0	KIT ETV6
36	indolent systemic mastocytosis	10.0	KIT FIP1L1
37	cerebellar angioblastoma	10.0	PDGFRA KIT ETV6
38	mastocytosis, cutaneous	10.0	PDGFRA KIT FIP1L1
39	mesenchymal cell neoplasm	10.0	PDGFRB PDGFRA KIT
40	desmoid tumor	10.0	PDGFRB PDGFRA KIT
41	neurilemmoma	9.9	PDGFRB PDGFRA KIT
42	endomyocardial fibrosis	9.9	PDGFRB PDGFRA FIP1L1 CHIC2
43	retinitis pigmentosa and erythrocytic microcytosis	9.9	JAK2 EPO
44	mixed phenotype acute leukemia	9.9	FGFR1 ABL1
45	budd-chiari syndrome	9.9	PDGFRA JAK2 FIP1L1
46	leiomyosarcoma	9.9	PDGFRB PDGFRA KIT
47	nephroma	9.9	KIT ETV6
48	core binding factor acute myeloid leukemia	9.9	KIT JAK2
49	malignant peripheral nerve sheath tumor	9.9	PDGFRB PDGFRA KIT
50	8p11 myeloproliferative syndrome	9.9	PDGFRB KIT FGFR1

Graphical network of the top 20 diseases related to Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement:

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Symptoms & Phenotypes for Myeloid and Lymphoid Neoplasms Associated with Pdgfra...

GenomeRNAi Phenotypes related to Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement according to GeneCards Suite gene sharing:

²⁶ (show all 17)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased substrate adherent cell growth	GR00193-A-1	9.77	KIT
2	Decreased substrate adherent cell growth	GR00193-A-2	9.77	ABL1 JAK2 KIT
3	Decreased substrate adherent cell growth	GR00193-A-3	9.77	JAK2
4	Decreased substrate adherent cell growth	GR00193-A-4	9.77	ABL1 KIT FGFR1
5	Decreased viability	GR00173-A	9.64	PDGFRA
6	Decreased viability	GR00221-A-1	9.64	ABL1 FGFR1 KIT PDGFRA PDGFRB
7	Decreased viability	GR00221-A-2	9.64	ABL1 FGFR1
8	Decreased viability	GR00221-A-3	9.64	ABL1 PDGFRA PDGFRB
9	Decreased viability	GR00221-A-4	9.64	PDGFRA PDGFRB
10	Decreased viability	GR00249-S	9.64	PDGFRA
11	Decreased viability	GR00301-A	9.64	KIT
12	Decreased viability	GR00342-S-1	9.64	ABL1 PDGFRB
13	Decreased viability	GR00342-S-2	9.64	ABL1
14	Decreased viability	GR00342-S-3	9.64	ABL1
15	Decreased viability	GR00386-A-1	9.64	FGFR1
16	Decreased viability	GR00402-S-2	9.64	PDGFRA
17	Decreased cell viability after pRB stimulation	GR00230-A-1	8.85	PDGFRB

MGI Mouse Phenotypes related to Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement:

⁴⁵ (show all 17)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.27	ABL1 CHIC2 CSF2 EPO ETV6 FGFR1
2	cellular	MP:0005384	10.21	ABL1 CSF2 EPO ETV6 FGFR1 JAK2
3	hematopoietic system	MP:0005397	10.19	ABL1 CHIC2 CSF2 EPO ETV6 FGFR1
4	embryo	MP:0005380	10.18	ABL1 CSF2 EPO ETV6 FGFR1 JAK2
5	endocrine/exocrine gland	MP:0005379	10.16	ABL1 CHIC2 CSF2 ETV6 FGFR1 JAK2
6	immune system	MP:0005387	10.16	ABL1 CHIC2 CSF2 EPO ETV6 FGFR1
7	homeostasis/metabolism	MP:0005376	10.13	ABL1 CSF2 EPO ETV6 FGFR1 JAK2
8	integument	MP:0010771	10.13	CHIC2 CSF2 EPO ETV6 FGFR1 JAK2
9	mortality/aging	MP:0010768	10.1	ABL1 CHIC2 CSF2 EPO ETV6 FGFR1
10	craniofacial	MP:0005382	10.02	ABL1 CSF2 FGFR1 KIT PDGFRA PDGFRB
11	digestive/alimentary	MP:0005381	10.01	ABL1 ETV6 FGFR1 KIT PDGFRA PDGFRB
12	normal	MP:0002873	9.86	ABL1 EPO ETV6 FGFR1 JAK2 KIT
13	muscle	MP:0005369	9.85	ABL1 EPO FGFR1 KIT PDGFRA PDGFRB
14	neoplasm	MP:0002006	9.72	CSF2 ETV6 JAK2 KIT PDGFRA
15	reproductive system	MP:0005389	9.7	CHIC2 CSF2 FGFR1 JAK2 KIT PDGFRA
16	respiratory system	MP:0005388	9.43	ABL1 CSF2 EPO JAK2 KIT PDGFRA
17	skeleton	MP:0005390	9.23	ABL1 CSF2 EPO FGFR1 JAK2 KIT

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Drugs & Therapeutics for Myeloid and Lymphoid Neoplasms Associated with Pdgfra...

Search Clinical Trials , NIH Clinical Center for Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement

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Genetic Tests for Myeloid and Lymphoid Neoplasms Associated with Pdgfra...

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Anatomical Context for Myeloid and Lymphoid Neoplasms Associated with Pdgfra...

MalaCards organs/tissues related to Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement:

⁴⁰

Myeloid

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Publications for Myeloid and Lymphoid Neoplasms Associated with Pdgfra...

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Genes for Myeloid and Lymphoid Neoplasms Associated with Pdgfra...

Genes related to Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement (1 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	354.04	Gene fusion ⁵⁸ DISEASES inferred ¹⁵
2	CHIC2	Cysteine Rich Hydrophobic Domain 2	Protein Coding	5.72	DISEASES inferred ¹⁵
3	FIP1L1	Factor Interacting With PAPOLA And CPSF1	Protein Coding	5.03	DISEASES inferred ¹⁵
4	RARS1	Arginyl-TRNA Synthetase 1	Protein Coding	4.58	DISEASES inferred ¹⁵
5	ETV6	ETS Variant Transcription Factor 6	Protein Coding	4.49	DISEASES inferred ¹⁵
6	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	3.96	DISEASES inferred ¹⁵
7	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	3.95	DISEASES inferred ¹⁵
8	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	3.83	DISEASES inferred ¹⁵
9	EPO	Erythropoietin	Protein Coding	3.62	DISEASES inferred ¹⁵
10	JAK2	Janus Kinase 2	Protein Coding	3.58	DISEASES inferred ¹⁵
11	CSF2	Colony Stimulating Factor 2	Protein Coding	3.34	DISEASES inferred ¹⁵
12	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	3.31	DISEASES inferred ¹⁵

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Variations for Myeloid and Lymphoid Neoplasms Associated with Pdgfra...

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Expression for Myeloid and Lymphoid Neoplasms Associated with Pdgfra...

Search GEO for disease gene expression data for Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement.

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Pathways for Myeloid and Lymphoid Neoplasms Associated with Pdgfra...

Pathways related to Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement according to GeneCards Suite gene sharing:

(show all 35)

#	Super pathways	Score	Top Affiliating Genes
1	ERK Signaling ⁶³ Show member pathways ILK Signaling ⁶³ MAPK Signaling ⁶³ Molecular Mechanisms of Cancer ⁶³ Rho Family GTPases ⁶³	13.65	PDGFRB PDGFRA KIT JAK2 FGFR1 CSF2
2	PEDF Induced Signaling ⁶³ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶³ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶³ Glucocorticoid Receptor Signaling ⁶³ IL-6 Pathway ⁶³ MIF Mediated Glucocorticoid Regulation ⁶³ MIF Regulation of Innate Immune Cells ⁶³ NFAT Signaling and Lymphocyte Interactions ⁶³ PGC1Alpha Pathway ⁶³ RAR-Gamma-RXR-Alpha Degradation ⁶³ STAT3 Pathway ⁶³	13.5	PDGFRB PDGFRA KIT JAK2 FGFR1 EPO
3	TGF-Beta Pathway ⁶³ Show member pathways JAK-STAT Pathway ⁶³ JNK Pathway ⁶³ MAPK Family Pathway ⁶³ Regulation of eIF4 and p70S6K ⁶³ SOCS Pathway ⁶³	13.37	PDGFRB PDGFRA KIT JAK2 FGFR1 EPO
4	Developmental Biology ⁶⁵ Show member pathways Axon guidance ⁶⁵	13.29	PDGFRB PDGFRA KIT JAK2 FGFR1 CSF2
5	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.24	PDGFRB PDGFRA KIT JAK2 FGFR1 CSF2
6	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.17	PDGFRB PDGFRA KIT JAK2 FGFR1 CSF2
7	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.1	PDGFRB PDGFRA KIT JAK2 FGFR1 CSF2
8	p70S6K Signaling ⁶³ Show member pathways mTOR Pathway ⁶³ Renin-Angiotensin Pathway ⁶³	12.88	PDGFRB PDGFRA KIT JAK2 FGFR1
9	Actin Nucleation by ARP-WASP Complex ⁶³ Show member pathways Actin Nucleation and Branching ⁶³ CDC42 Pathway ⁶³ RhoA Pathway ⁶³	12.8	PDGFRB PDGFRA KIT FGFR1
10	PI3K-Akt signaling pathway ³⁶ Show member pathways Human papillomavirus infection ³⁶	12.72	PDGFRB PDGFRA KIT JAK2 FGFR1 EPO
11	NFAT and Cardiac Hypertrophy ⁶³ Show member pathways IGF1R Signaling ⁶³ Signaling Involved in Cardiac Hypertrophy ⁶³	12.71	PDGFRB PDGFRA JAK2 FGFR1
12	Development Angiotensin activation of ERK ²² Show member pathways Cell adhesion Integrin inside-out signaling ²² Development ACM2 and ACM4 activation of ERK ²² Development Angiotensin signaling via PYK2 ²² Development EDNRB signaling ²² Development EPO-induced MAPK pathway ²² Development G-Proteins mediated regulation MARK-ERK signaling ²² Signal transduction IP3 signaling ²²	12.62	PDGFRB PDGFRA KIT JAK2 EPO
13	MAPK signaling pathway ³⁶ ¹	12.61	PDGFRB PDGFRA KIT FGFR1
14	Endometrial cancer ³⁶ Show member pathways Acute myeloid leukemia ³⁶ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²² Thyroid cancer ³⁶	12.59	PDGFRB PDGFRA KIT FGFR1 CSF2 ABL1
15	Downstream signaling events of B Cell Receptor (BCR) ⁶⁵ Show member pathways Activation of RAS in B cells ⁶⁵ Signaling by the B Cell Receptor (BCR) ⁶⁵	12.58	PDGFRB PDGFRA KIT FGFR1
16	Ras signaling pathway ³⁶ Show member pathways Rap1 signaling pathway ³⁶	12.55	PDGFRB PDGFRA KIT FGFR1 ABL1
17	ErbB signaling pathway ³⁶ ¹ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ³⁶ Renal cell carcinoma ³⁶ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.46	PDGFRB PDGFRA JAK2 ABL1
18	G-protein signaling RAC1 in cellular process ²² Show member pathways CDC42 signaling events ¹ Cytoskeleton remodeling CDC42 in cellular processes ²² RAC1 signaling pathway ¹	12.25	PDGFRB PDGFRA KIT FGFR1
19	Pathways in cancer ³⁶	12.22	PDGFRB PDGFRA KIT JAK2 FGFR1 EPO
20	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	12.04	PDGFRB PDGFRA KIT FGFR1 ABL1
21	Kit receptor signaling pathway ¹ Show member pathways IL-3 Signaling Pathway ¹ Signaling events mediated by Stem cell factor receptor (c-Kit) ¹	12.03	KIT JAK2 EPO
22	JAK-STAT signaling pathway ³⁶ Show member pathways B-Cell Development ⁶³ IL-7 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁴ Interleukin-19, 20, 22, 24 ⁶⁵ Jak/STAT Signaling Pathway ⁶⁴ Type III interferon signaling ¹	12.03	PDGFRB PDGFRA JAK2 EPO CSF2 ABL1
23	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁴	11.86	KIT EPO CSF2
24	Hematopoietic cell lineage ³⁶	11.76	KIT EPO CSF2
25	Angiogenesis (CST) ⁴	11.7	PDGFRB PDGFRA FGFR1
26	VEGF Pathway (Tocris) ⁶⁰ Show member pathways VEGF Pathway ⁷⁰	11.66	PDGFRB KIT FGFR1
27	Central carbon metabolism in cancer ³⁶	11.47	PDGFRB PDGFRA KIT FGFR1
28	Alzheimers Disease Pathway ⁶³	11.35	PDGFRB PDGFRA FGFR1
29	Vemurafenib Pathway, Pharmacodynamics ⁶⁰	11.3	PDGFRB PDGFRA FGFR1
30	Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Show member pathways Bosutinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Imatinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Nilotinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Taxane Pathway, Pharmacokinetics ⁶⁰	11.27	PDGFRB PDGFRA KIT ABL1
31	Tyrosine Kinases / Adaptors ⁴	11.27	PDGFRB PDGFRA KIT JAK2 FGFR1 ABL1
32	Pazopanib Pathway, Pharmacokinetics ⁶⁰ Show member pathways Sunitinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	11.18	PDGFRB PDGFRA KIT
33	Cytoskeleton remodeling_Role of PDGFs in cell migration ²²	11.02	PDGFRB PDGFRA
34	G-protein signaling_Rap2B regulation pathway ²²	10.85	PDGFRB PDGFRA KIT FGFR1 CSF2
35	Osteoblast Signaling ¹	10.77	PDGFRB PDGFRA

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GO Terms for Myeloid and Lymphoid Neoplasms Associated with Pdgfra...

Cellular components related to Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	receptor complex	GO:0043235	8.92	PDGFRB PDGFRA KIT FGFR1

Biological processes related to Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement according to GeneCards Suite gene sharing:

(show all 36)

#	Name	GO ID	Score	Top Affiliating Genes
1	phosphorylation	GO:0016310	9.99	PDGFRB PDGFRA KIT JAK2 FGFR1 ABL1
2	protein phosphorylation	GO:0006468	9.95	PDGFRB PDGFRA KIT JAK2 FGFR1 ABL1
3	positive regulation of cell proliferation	GO:0008284	9.95	PDGFRB PDGFRA KIT JAK2 FGFR1 EPO
4	positive regulation of cell migration	GO:0030335	9.92	PDGFRB PDGFRA KIT JAK2
5	positive regulation of ERK1 and ERK2 cascade	GO:0070374	9.91	PDGFRB PDGFRA EPO ABL1
6	regulation of cell proliferation	GO:0042127	9.9	KIT FGFR1 CSF2 ABL1
7	positive regulation of protein kinase B signaling	GO:0051897	9.86	PDGFRB PDGFRA KIT FGFR1
8	positive regulation of cytosolic calcium ion concentration	GO:0007204	9.85	PDGFRA JAK2 ABL1
9	cell chemotaxis	GO:0060326	9.82	PDGFRB PDGFRA KIT
10	hematopoietic progenitor cell differentiation	GO:0002244	9.8	PDGFRB PDGFRA KIT
11	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	9.8	PDGFRB PDGFRA KIT FGFR1
12	MAPK cascade	GO:0000165	9.8	PDGFRB PDGFRA KIT JAK2 FGFR1 CSF2
13	positive regulation of MAP kinase activity	GO:0043406	9.79	PDGFRB KIT FGFR1
14	phosphatidylinositol-mediated signaling	GO:0048015	9.77	PDGFRB PDGFRA FGFR1
15	positive regulation of kinase activity	GO:0033674	9.76	PDGFRB PDGFRA KIT FGFR1
16	erythrocyte differentiation	GO:0030218	9.75	KIT JAK2 EPO
17	skeletal system morphogenesis	GO:0048705	9.74	PDGFRB PDGFRA FGFR1
18	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.73	KIT JAK2 EPO CSF2
19	protein autophosphorylation	GO:0046777	9.73	PDGFRB PDGFRA KIT JAK2 FGFR1 ABL1
20	positive regulation of phosphatidylinositol 3-kinase activity	GO:0043552	9.7	PDGFRB PDGFRA KIT
21	regulation of actin cytoskeleton reorganization	GO:2000249	9.67	PDGFRA ABL1
22	platelet-derived growth factor receptor signaling pathway	GO:0048008	9.67	PDGFRB PDGFRA JAK2 ABL1
23	adrenal gland development	GO:0030325	9.66	PDGFRB PDGFRA
24	response to hyperoxia	GO:0055093	9.66	PDGFRB EPO
25	cardiac myofibril assembly	GO:0055003	9.65	PDGFRB PDGFRA
26	positive regulation of phosphoprotein phosphatase activity	GO:0032516	9.65	PDGFRB JAK2
27	negative regulation of cell-cell adhesion	GO:0022408	9.65	JAK2 ABL1
28	response to fluid shear stress	GO:0034405	9.64	PDGFRB CSF2
29	retina vasculature development in camera-type eye	GO:0061298	9.63	PDGFRB PDGFRA
30	platelet-derived growth factor receptor-beta signaling pathway	GO:0035791	9.61	PDGFRB ABL1
31	erythropoietin-mediated signaling pathway	GO:0038162	9.58	KIT EPO
32	metanephric glomerular capillary formation	GO:0072277	9.55	PDGFRB PDGFRA
33	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	GO:0038091	9.54	PDGFRB PDGFRA
34	positive regulation of phospholipase C activity	GO:0010863	9.46	PDGFRB PDGFRA KIT FGFR1
35	peptidyl-tyrosine phosphorylation	GO:0018108	9.43	PDGFRB PDGFRA KIT JAK2 FGFR1 ABL1
36	positive regulation of phosphatidylinositol 3-kinase signaling	GO:0014068	9.1	PDGFRB PDGFRA KIT JAK2 FGFR1 EPO

Molecular functions related to Myeloid and Lymphoid Neoplasms Associated with Pdgfra Rearrangement according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	10.29	RARS1 PDGFRB PDGFRA KIT JAK2 FIP1L1
2	transferase activity	GO:0016740	10.01	PDGFRB PDGFRA KIT JAK2 FGFR1 ABL1
3	nucleotide binding	GO:0000166	9.98	RARS1 PDGFRB PDGFRA KIT JAK2 FGFR1
4	ATP binding	GO:0005524	9.91	RARS1 PDGFRB PDGFRA KIT JAK2 FGFR1
5	kinase activity	GO:0016301	9.8	PDGFRB PDGFRA KIT JAK2 FGFR1 ABL1
6	protein kinase activity	GO:0004672	9.73	PDGFRB PDGFRA KIT JAK2 FGFR1 ABL1
7	growth factor binding	GO:0019838	9.58	PDGFRB PDGFRA KIT
8	phosphatidylinositol 3-kinase binding	GO:0043548	9.52	PDGFRB JAK2
9	platelet-derived growth factor receptor binding	GO:0005161	9.49	PDGFRB PDGFRA
10	platelet-derived growth factor binding	GO:0048407	9.48	PDGFRB PDGFRA
11	vascular endothelial growth factor binding	GO:0038085	9.46	PDGFRB PDGFRA
12	transmembrane receptor protein tyrosine kinase activity	GO:0004714	9.46	PDGFRB PDGFRA KIT FGFR1
13	SH2 domain binding	GO:0042169	9.26	KIT JAK2 FGFR1 ABL1
14	protein tyrosine kinase activity	GO:0004713	9.1	PDGFRB PDGFRA KIT JAK2 FGFR1 ABL1

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⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia