MCID: MYL059
MIFTS: 27

Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Myeloid and Lymphoid Neoplasms with Eosinophilia and...

MalaCards integrated aliases for Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1:

Name: Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1 12 15
Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Platelet-Derived Growth Factor Receptor Alpha , Platelet-Derived Growth Factor Receptor Beta , and Fibroblast Growth Factor Receptor-1 Are a Group of Hematologic Neoplasms 12
Myeloid and Lymphoid Neoplasms with Eosinophilia and Rearrangement of Pdgfra, Pdgfrb, or Fgfr1, or with Pcm1-Jak2 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0080164
NCIt 49 C84270
UMLS 71 C2827356

Summaries for Myeloid and Lymphoid Neoplasms with Eosinophilia and...

Disease Ontology : 12 A myeloid neoplasm that is characterized by the formation of abnormal fusion genes that encode constitutively activated tyrosine kinases.

MalaCards based summary : Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1, also known as myeloid and lymphoid neoplasms with eosinophilia and abnormalities of platelet-derived growth factor receptor alpha , platelet-derived growth factor receptor beta , and fibroblast growth factor receptor-1 are a group of hematologic neoplasms, is related to myeloid and lymphoid neoplasms associated with fgfr1 abnormalities and myeloid and lymphoid neoplasms associated with pdgfra rearrangement. An important gene associated with Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1 is ZNF112 (Zinc Finger Protein 112), and among its related pathways/superpathways are Actin Nucleation by ARP-WASP Complex and NFAT and Cardiac Hypertrophy. Affiliated tissues include myeloid, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Myeloid and Lymphoid Neoplasms with Eosinophilia and...

Diseases related to Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 myeloid and lymphoid neoplasms associated with fgfr1 abnormalities 32.3 ZNF112 ZMYM2 FGFR1
2 myeloid and lymphoid neoplasms associated with pdgfra rearrangement 31.9 PDGFRB PDGFRA FGFR1
3 hypereosinophilic syndrome 29.8 PDGFRB PDGFRA FGFR1
4 myeloid and lymphoid neoplasms associated with pdgfrb rearrangement 11.9
5 myelodysplastic/myeloproliferative neoplasm 10.0 PDGFRB DPM1
6 b-lymphoblastic leukemia/lymphoma 9.8 ZMYM2 FGFR1
7 hypereosinophilic syndrome, idiopathic 9.8 PDGFRB PDGFRA
8 endomyocardial fibrosis 9.8 PDGFRB PDGFRA
9 mesenchymal cell neoplasm 9.7 PDGFRB PDGFRA
10 desmoid tumor 9.7 PDGFRB PDGFRA
11 lymphoblastic lymphoma 9.7 ZMYM2 FGFR1
12 costello syndrome 9.7 PDGFRB PDGFRA
13 aggressive systemic mastocytosis 9.7 PDGFRB PDGFRA
14 chronic leukemia 9.6 PDGFRB PDGFRA
15 neurilemmoma 9.6 PDGFRB PDGFRA
16 8p11 myeloproliferative syndrome 9.6 ZMYM2 PDGFRB FGFR1
17 giant cell glioblastoma 9.5 PDGFRA FGFR1
18 myelofibrosis 9.5 ZMYM2 PDGFRB FGFR1
19 dermatofibrosarcoma protuberans 9.4 PDGFRB PDGFRA
20 large cell carcinoma 9.4 PDGFRA FGFR1
21 primary hypereosinophilic syndrome 9.3 PDGFRB PDGFRA FGFR1
22 atypical chronic myeloid leukemia 9.3 PDGFRB PDGFRA FGFR1
23 brain stem glioma 9.3 PDGFRB PDGFRA FGFR1
24 glioma 9.3 PDGFRB PDGFRA FGFR1
25 systemic mastocytosis 9.3 PDGFRB PDGFRA FGFR1
26 mastocytosis 9.3 PDGFRB PDGFRA FGFR1
27 gliosarcoma 9.3 PDGFRB PDGFRA FGFR1
28 sarcoma 9.3 PDGFRB PDGFRA FGFR1
29 leiomyosarcoma 9.3 PDGFRB PDGFRA
30 ewing sarcoma 9.2 PDGFRB PDGFRA FGFR1
31 pancreatic adenocarcinoma 9.1 PDGFRB PDGFRA FGFR1
32 myeloproliferative neoplasm 8.9 ZMYM2 PDGFRB PDGFRA FGFR1
33 leukemia, chronic myeloid 8.9 PDGFRB PDGFRA FGFR1 DPM1
34 chronic eosinophilic leukemia 8.6 ZMYM2 PDGFRB PDGFRA FGFR1 DPM1

Graphical network of the top 20 diseases related to Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1:



Diseases related to Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1

Symptoms & Phenotypes for Myeloid and Lymphoid Neoplasms with Eosinophilia and...

GenomeRNAi Phenotypes related to Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00173-A 9.77 PDGFRA
2 Decreased viability GR00221-A-1 9.77 FGFR1 PDGFRA PDGFRB
3 Decreased viability GR00221-A-2 9.77 FGFR1
4 Decreased viability GR00221-A-3 9.77 PDGFRA PDGFRB
5 Decreased viability GR00221-A-4 9.77 PDGFRA PDGFRB
6 Decreased viability GR00249-S 9.77 PDGFRA
7 Decreased viability GR00342-S-1 9.77 PDGFRB
8 Decreased viability GR00386-A-1 9.77 FGFR1
9 Decreased viability GR00402-S-2 9.77 PDGFRA
10 Increased colony dispersion (increased number of colonies and decreased number of cells per colony) GR00212-A 8.62 FGFR1 PDGFRA

MGI Mouse Phenotypes related to Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 8.92 DPM1 FGFR1 PDGFRA PDGFRB

Drugs & Therapeutics for Myeloid and Lymphoid Neoplasms with Eosinophilia and...

Search Clinical Trials , NIH Clinical Center for Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1

Genetic Tests for Myeloid and Lymphoid Neoplasms with Eosinophilia and...

Anatomical Context for Myeloid and Lymphoid Neoplasms with Eosinophilia and...

MalaCards organs/tissues related to Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1:

40
Myeloid

Publications for Myeloid and Lymphoid Neoplasms with Eosinophilia and...

Articles related to Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1:

# Title Authors PMID Year
1
Hematolymphoid neoplasms associated with rearrangements of PDGFRA, PDGFRB, and FGFR1. 61
26276769 2015
2
Hematologic malignancies with PCM1-JAK2 gene fusion share characteristics with myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1. 61
23400675 2013
3
The World Health Organization (WHO) classification of tumors of the hematopoietic and lymphoid tissues: an overview with emphasis on the myeloid neoplasms. 61
19857474 2010
4
The 2008 World Health Organization classification system for myeloproliferative neoplasms: order out of chaos. 61
19472396 2009

Variations for Myeloid and Lymphoid Neoplasms with Eosinophilia and...

Expression for Myeloid and Lymphoid Neoplasms with Eosinophilia and...

Search GEO for disease gene expression data for Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1.

Pathways for Myeloid and Lymphoid Neoplasms with Eosinophilia and...

Pathways related to Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1 according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.62 PDGFRB PDGFRA FGFR1
2
Show member pathways
12.56 PDGFRB PDGFRA FGFR1
3
Show member pathways
12.56 PDGFRB PDGFRA FGFR1
4 12.52 PDGFRB PDGFRA FGFR1
5 12.43 PDGFRB PDGFRA FGFR1
6
Show member pathways
12.4 PDGFRB PDGFRA FGFR1
7
Show member pathways
12.38 PDGFRB PDGFRA FGFR1
8
Show member pathways
12.33 PDGFRB PDGFRA FGFR1
9 12.28 PDGFRB PDGFRA FGFR1
10
Show member pathways
12.12 PDGFRB PDGFRA FGFR1
11
Show member pathways
12.06 PDGFRB PDGFRA FGFR1
12
Show member pathways
12.03 PDGFRB PDGFRA FGFR1
13
Show member pathways
11.91 PDGFRB PDGFRA FGFR1
14
Show member pathways
11.87 PDGFRB PDGFRA FGFR1
15 11.67 PDGFRB PDGFRA FGFR1
16
Show member pathways
11.58 ZMYM2 FGFR1
17 11.57 PDGFRB PDGFRA
18
Show member pathways
11.53 PDGFRB FGFR1
19 11.5 PDGFRA FGFR1
20 11.38 PDGFRB PDGFRA FGFR1
21 11.36 PDGFRB PDGFRA FGFR1
22
Show member pathways
11.26 PDGFRB PDGFRA
23 11.18 PDGFRB PDGFRA FGFR1
24
Show member pathways
10.99 PDGFRB PDGFRA
25 10.79 PDGFRB PDGFRA FGFR1
26 10.77 PDGFRB PDGFRA
27 10.71 PDGFRB PDGFRA FGFR1
28 10.51 PDGFRB PDGFRA
29 10.43 PDGFRB PDGFRA FGFR1

GO Terms for Myeloid and Lymphoid Neoplasms with Eosinophilia and...

Cellular components related to Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intrinsic component of plasma membrane GO:0031226 8.96 PDGFRB PDGFRA
2 receptor complex GO:0043235 8.8 PDGFRB PDGFRA FGFR1

Biological processes related to Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1 according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.79 PDGFRB PDGFRA FGFR1
2 MAPK cascade GO:0000165 9.74 PDGFRB PDGFRA FGFR1
3 cell migration GO:0016477 9.73 PDGFRB PDGFRA FGFR1
4 in utero embryonic development GO:0001701 9.72 PDGFRB PDGFRA FGFR1
5 positive regulation of protein kinase B signaling GO:0051897 9.7 PDGFRB PDGFRA FGFR1
6 protein autophosphorylation GO:0046777 9.69 PDGFRB PDGFRA FGFR1
7 peptidyl-tyrosine phosphorylation GO:0018108 9.65 PDGFRB PDGFRA FGFR1
8 lung development GO:0030324 9.63 PDGFRA FGFR1
9 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.63 PDGFRB PDGFRA FGFR1
10 wound healing GO:0042060 9.62 PDGFRB PDGFRA
11 cell chemotaxis GO:0060326 9.61 PDGFRB PDGFRA
12 hematopoietic progenitor cell differentiation GO:0002244 9.61 PDGFRB PDGFRA
13 positive regulation of MAP kinase activity GO:0043406 9.6 PDGFRB FGFR1
14 positive regulation of fibroblast proliferation GO:0048146 9.59 PDGFRB PDGFRA
15 platelet-derived growth factor receptor signaling pathway GO:0048008 9.58 PDGFRB PDGFRA
16 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.58 PDGFRB PDGFRA
17 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.58 PDGFRB PDGFRA FGFR1
18 adrenal gland development GO:0030325 9.54 PDGFRB PDGFRA
19 positive regulation of kinase activity GO:0033674 9.54 PDGFRB PDGFRA FGFR1
20 phosphatidylinositol-mediated signaling GO:0048015 9.5 PDGFRB PDGFRA FGFR1
21 cardiac myofibril assembly GO:0055003 9.49 PDGFRB PDGFRA
22 retina vasculature development in camera-type eye GO:0061298 9.43 PDGFRB PDGFRA
23 metanephric glomerular capillary formation GO:0072277 9.26 PDGFRB PDGFRA
24 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 9.16 PDGFRB PDGFRA
25 skeletal system morphogenesis GO:0048705 9.13 PDGFRB PDGFRA FGFR1
26 positive regulation of phospholipase C activity GO:0010863 8.8 PDGFRB PDGFRA FGFR1

Molecular functions related to Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.58 PDGFRB PDGFRA FGFR1
2 growth factor binding GO:0019838 9.37 PDGFRB PDGFRA
3 protein tyrosine kinase activity GO:0004713 9.33 PDGFRB PDGFRA FGFR1
4 platelet-derived growth factor receptor binding GO:0005161 9.32 PDGFRB PDGFRA
5 platelet-derived growth factor binding GO:0048407 9.26 PDGFRB PDGFRA
6 vascular endothelial growth factor binding GO:0038085 8.96 PDGFRB PDGFRA
7 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.8 PDGFRB PDGFRA FGFR1

Sources for Myeloid and Lymphoid Neoplasms with Eosinophilia and...

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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