MCID: MYL059
MIFTS: 33

Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Myeloid and Lymphoid Neoplasms with Eosinophilia and...

MalaCards integrated aliases for Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1:

Name: Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1 12 15
Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Platelet-Derived Growth Factor Receptor Alpha , Platelet-Derived Growth Factor Receptor Beta , and Fibroblast Growth Factor Receptor-1 Are a Group of Hematologic Neoplasms 12
Myeloid and Lymphoid Neoplasms with Eosinophilia and Rearrangement of Pdgfra, Pdgfrb, or Fgfr1, or with Pcm1-Jak2 12

Classifications:



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Disease Ontology 12 DOID:0080164
NCIt 50 C84270
UMLS 73 C2827356

Summaries for Myeloid and Lymphoid Neoplasms with Eosinophilia and...

Disease Ontology : 12 A myeloid neoplasm that is characterized by the formation of abnormal fusion genes that encode constitutively activated tyrosine kinases.

MalaCards based summary : Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1, also known as myeloid and lymphoid neoplasms with eosinophilia and abnormalities of platelet-derived growth factor receptor alpha , platelet-derived growth factor receptor beta , and fibroblast growth factor receptor-1 are a group of hematologic neoplasms, is related to myeloid and lymphoid neoplasms associated with pdgfra rearrangement and myeloid neoplasms associated with pdgfrb rearrangement. An important gene associated with Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1 is PDGFRB (Platelet Derived Growth Factor Receptor Beta), and among its related pathways/superpathways are TGF-Beta Pathway and Developmental Biology. Affiliated tissues include myeloid, bone and heart, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Myeloid and Lymphoid Neoplasms with Eosinophilia and...

Diseases related to Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 myeloid and lymphoid neoplasms associated with pdgfra rearrangement 11.8
2 myeloid neoplasms associated with pdgfrb rearrangement 11.8
3 myeloid and lymphoid neoplasms associated with fgfr1 abnormalities 11.8
4 mastocytosis 10.0 PDGFRA PDGFRB
5 8p11 myeloproliferative syndrome 10.0 FGFR1 PDGFRB
6 desmoid tumor 10.0 PDGFRA PDGFRB
7 hypereosinophilic syndrome, idiopathic 10.0 PDGFRA PDGFRB
8 heart sarcoma 10.0 PDGFRA PDGFRB
9 corneal dystrophy, subepithelial mucinous 10.0 PDGFRA PDGFRB
10 spinal chordoma 10.0 PDGFRA PDGFRB
11 chordoma 10.0 PDGFRA PDGFRB
12 fibrosarcoma of bone 10.0 PDGFRA PDGFRB
13 dermatofibrosarcoma protuberans 9.9 PDGFRA PDGFRB
14 lymphoblastic leukemia, acute, with lymphomatous features 9.9 FGFR1 JAK2
15 leiomyosarcoma 9.9 PDGFRA PDGFRB
16 erythrocytosis, familial, 1 9.9 DPM1 JAK2
17 primary polycythemia 9.9 DPM1 JAK2
18 thrombocytopenia-absent radius syndrome 9.9 FGFR1 JAK2
19 primary hypereosinophilic syndrome 9.8 FGFR1 PDGFRA PDGFRB
20 hypereosinophilic syndrome 9.8 FGFR1 PDGFRA PDGFRB
21 chronic eosinophilic leukemia 9.8 FGFR1 PDGFRA PDGFRB
22 glioma 9.8 FGFR1 PDGFRA PDGFRB
23 budd-chiari syndrome 9.8 JAK2 PDGFRA
24 glioblastoma 9.7 FGFR1 PDGFRA PDGFRB
25 hematologic cancer 9.7 FGFR1 JAK2 PDGFRB
26 atypical chronic myeloid leukemia 9.7 JAK2 PDGFRA PDGFRB
27 polycythemia vera 9.7 JAK2 PDGFRA PDGFRB
28 juvenile myelomonocytic leukemia 9.7 JAK2 PDGFRA PDGFRB
29 chronic myelomonocytic leukemia 9.7 JAK2 PDGFRB
30 ewing sarcoma 9.7 FGFR1 PDGFRA PDGFRB
31 systemic mastocytosis 9.5 FGFR1 JAK2 PDGFRA PDGFRB
32 myeloproliferative neoplasm 9.5 FGFR1 JAK2 PDGFRA PDGFRB
33 bone marrow cancer 9.5 FGFR1 JAK2 PDGFRA PDGFRB
34 leukemia, chronic myeloid 9.5 FGFR1 JAK2 PDGFRA PDGFRB

Graphical network of the top 20 diseases related to Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1:



Diseases related to Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1

Symptoms & Phenotypes for Myeloid and Lymphoid Neoplasms with Eosinophilia and...

GenomeRNAi Phenotypes related to Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00173-A 9.97 PDGFRA
2 Decreased viability GR00221-A-1 9.97 FGFR1 PDGFRA PDGFRB
3 Decreased viability GR00221-A-2 9.97 FGFR1
4 Decreased viability GR00221-A-3 9.97 PDGFRA PDGFRB
5 Decreased viability GR00221-A-4 9.97 PDGFRA PDGFRB
6 Decreased viability GR00342-S-1 9.97 PDGFRB
7 Decreased viability GR00402-S-2 9.97 FGFR1 PDGFRA PDGFRB
8 Increased cell death HMECs cells GR00103-A-0 9.13 FGFR1 JAK2 PDGFRB
9 Increased colony dispersion (increased number of colonies and decreased number of cells per colony) GR00212-A 8.62 FGFR1 PDGFRA

MGI Mouse Phenotypes related to Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.46 FGFR1 JAK2 PDGFRA PDGFRB
2 integument MP:0010771 9.26 FGFR1 JAK2 PDGFRA PDGFRB
3 normal MP:0002873 8.92 FGFR1 JAK2 PDGFRA PDGFRB

Drugs & Therapeutics for Myeloid and Lymphoid Neoplasms with Eosinophilia and...

Search Clinical Trials , NIH Clinical Center for Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1

Genetic Tests for Myeloid and Lymphoid Neoplasms with Eosinophilia and...

Anatomical Context for Myeloid and Lymphoid Neoplasms with Eosinophilia and...

MalaCards organs/tissues related to Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1:

41
Myeloid, Bone, Heart, Bone Marrow

Publications for Myeloid and Lymphoid Neoplasms with Eosinophilia and...

Articles related to Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1:

# Title Authors Year
1
Hematologic malignancies with PCM1-JAK2 gene fusion share characteristics with myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1. ( 23400675 )
2013

Variations for Myeloid and Lymphoid Neoplasms with Eosinophilia and...

Expression for Myeloid and Lymphoid Neoplasms with Eosinophilia and...

Search GEO for disease gene expression data for Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1.

Pathways for Myeloid and Lymphoid Neoplasms with Eosinophilia and...

Pathways related to Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1 according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.21 FGFR1 JAK2 PDGFRA PDGFRB
2
Show member pathways
13.16 FGFR1 JAK2 PDGFRA PDGFRB
3
Show member pathways
13.08 FGFR1 JAK2 PDGFRA PDGFRB
4
Show member pathways
13.03 FGFR1 JAK2 PDGFRA PDGFRB
5
Show member pathways
12.96 FGFR1 JAK2 PDGFRA PDGFRB
6
Show member pathways
12.71 FGFR1 JAK2 PDGFRA PDGFRB
7
Show member pathways
12.7 FGFR1 PDGFRA PDGFRB
8
Show member pathways
12.63 JAK2 PDGFRA PDGFRB
9
Show member pathways
12.62 FGFR1 JAK2 PDGFRA PDGFRB
10
Show member pathways
12.59 FGFR1 PDGFRA PDGFRB
11
Show member pathways
12.5 FGFR1 JAK2 PDGFRA PDGFRB
12 12.49 FGFR1 PDGFRA PDGFRB
13
Show member pathways
12.46 FGFR1 PDGFRA PDGFRB
14
Show member pathways
12.45 FGFR1 PDGFRA PDGFRB
15 12.45 FGFR1 JAK2 PDGFRA PDGFRB
16
Show member pathways
12.38 FGFR1 JAK2 PDGFRA PDGFRB
17 12.35 FGFR1 PDGFRA PDGFRB
18
Show member pathways
12.31 JAK2 PDGFRA PDGFRB
19
Show member pathways
12.21 FGFR1 PDGFRA PDGFRB
20
Show member pathways
12.15 FGFR1 PDGFRA PDGFRB
21
Show member pathways
12.12 FGFR1 PDGFRA PDGFRB
22
Show member pathways
12.12 JAK2 PDGFRA PDGFRB
23
Show member pathways
11.99 FGFR1 PDGFRA PDGFRB
24
Show member pathways
11.92 FGFR1 PDGFRA PDGFRB
25 11.84 FGFR1 PDGFRA PDGFRB
26
Show member pathways
11.75 JAK2 PDGFRB
27 11.73 PDGFRA PDGFRB
28 11.62 PDGFRA PDGFRB
29
Show member pathways
11.58 FGFR1 PDGFRB
30 11.56 FGFR1 PDGFRA
31
Show member pathways
11.54 PDGFRA PDGFRB
32 11.49 FGFR1 PDGFRA PDGFRB
33 11.45 FGFR1 PDGFRA PDGFRB
34 11.32 JAK2 PDGFRB
35 11.31 FGFR1 PDGFRA PDGFRB
36 11.09 FGFR1 PDGFRA PDGFRB
37 11.09 FGFR1 JAK2 PDGFRA PDGFRB
38 10.9 PDGFRA PDGFRB
39 10.84 FGFR1 JAK2 PDGFRA PDGFRB
40 10.76 FGFR1 PDGFRA PDGFRB
41 10.74 FGFR1 PDGFRA PDGFRB
42 10.64 PDGFRA PDGFRB

GO Terms for Myeloid and Lymphoid Neoplasms with Eosinophilia and...

Cellular components related to Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intrinsic component of plasma membrane GO:0031226 8.96 PDGFRA PDGFRB
2 receptor complex GO:0043235 8.8 FGFR1 PDGFRA PDGFRB

Biological processes related to Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1 according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.91 FGFR1 JAK2 PDGFRA PDGFRB
2 phosphorylation GO:0016310 9.86 FGFR1 JAK2 PDGFRA PDGFRB
3 protein phosphorylation GO:0006468 9.85 FGFR1 JAK2 PDGFRA PDGFRB
4 positive regulation of cell proliferation GO:0008284 9.83 FGFR1 JAK2 PDGFRA PDGFRB
5 negative regulation of apoptotic process GO:0043066 9.81 FGFR1 PDGFRA PDGFRB
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.78 FGFR1 PDGFRA PDGFRB
7 positive regulation of cell migration GO:0030335 9.77 JAK2 PDGFRA PDGFRB
8 cell migration GO:0016477 9.76 FGFR1 PDGFRA PDGFRB
9 positive regulation of protein kinase B signaling GO:0051897 9.74 FGFR1 PDGFRA PDGFRB
10 positive regulation of MAPK cascade GO:0043410 9.71 FGFR1 PDGFRA PDGFRB
11 negative regulation of signal transduction GO:0009968 9.67 FGFR1 PDGFRA PDGFRB
12 MAPK cascade GO:0000165 9.67 FGFR1 JAK2 PDGFRA PDGFRB
13 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.65 PDGFRA PDGFRB
14 wound healing GO:0042060 9.65 PDGFRA PDGFRB
15 lung development GO:0030324 9.65 FGFR1 PDGFRA
16 phosphatidylinositol phosphorylation GO:0046854 9.65 FGFR1 PDGFRA PDGFRB
17 cell chemotaxis GO:0060326 9.64 PDGFRA PDGFRB
18 positive regulation of MAP kinase activity GO:0043406 9.63 FGFR1 PDGFRB
19 positive regulation of fibroblast proliferation GO:0048146 9.63 PDGFRA PDGFRB
20 skeletal system morphogenesis GO:0048705 9.62 FGFR1 PDGFRA
21 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.62 PDGFRA PDGFRB
22 cardiac myofibril assembly GO:0055003 9.59 PDGFRA PDGFRB
23 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.58 JAK2 PDGFRB
24 phosphatidylinositol-mediated signaling GO:0048015 9.58 FGFR1 PDGFRA PDGFRB
25 peptidyl-tyrosine phosphorylation GO:0018108 9.56 FGFR1 JAK2 PDGFRA PDGFRB
26 retina vasculature development in camera-type eye GO:0061298 9.51 PDGFRA PDGFRB
27 platelet-derived growth factor receptor signaling pathway GO:0048008 9.5 JAK2 PDGFRA PDGFRB
28 metanephric glomerular capillary formation GO:0072277 9.46 PDGFRA PDGFRB
29 protein autophosphorylation GO:0046777 9.46 FGFR1 JAK2 PDGFRA PDGFRB
30 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 9.43 PDGFRA PDGFRB
31 positive regulation of phospholipase C activity GO:0010863 9.13 FGFR1 PDGFRA PDGFRB
32 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 8.92 FGFR1 JAK2 PDGFRA PDGFRB

Molecular functions related to Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of Pdgfra, Pdgfrb, and Fgfr1 according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.84 FGFR1 JAK2 PDGFRA PDGFRB
2 transferase activity GO:0016740 9.83 DPM1 FGFR1 JAK2 PDGFRA PDGFRB
3 kinase activity GO:0016301 9.78 FGFR1 JAK2 PDGFRA PDGFRB
4 protein kinase activity GO:0004672 9.71 FGFR1 JAK2 PDGFRA PDGFRB
5 transmembrane signaling receptor activity GO:0004888 9.69 FGFR1 PDGFRA PDGFRB
6 nucleotide binding GO:0000166 9.62 FGFR1 JAK2 PDGFRA PDGFRB
7 phosphatidylinositol 3-kinase binding GO:0043548 9.52 JAK2 PDGFRB
8 platelet-derived growth factor receptor binding GO:0005161 9.49 PDGFRA PDGFRB
9 platelet-derived growth factor binding GO:0048407 9.46 PDGFRA PDGFRB
10 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.43 FGFR1 PDGFRA PDGFRB
11 vascular endothelial growth factor binding GO:0038085 9.37 PDGFRA PDGFRB
12 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.33 FGFR1 PDGFRA PDGFRB
13 protein tyrosine kinase activity GO:0004713 9.26 FGFR1 JAK2 PDGFRA PDGFRB
14 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.92 FGFR1 JAK2 PDGFRA PDGFRB

Sources for Myeloid and Lymphoid Neoplasms with Eosinophilia and...

3 CDC
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11 DGIdb
17 ExPASy
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