Myeloid Sarcoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MYL003 MIFTS: 48	Myeloid Sarcoma Categories: Blood diseases, Cancer diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Myeloid Sarcoma

MalaCards integrated aliases for Myeloid Sarcoma:

Name: Myeloid Sarcoma ¹¹ ¹⁹ ⁵⁸ ¹⁴ ¹⁶ ⁷⁵ ³¹ ³³

Granulocytic Sarcoma ¹¹ ¹⁹ ⁵⁸ ¹⁶ ⁷¹ ³³

Chloroma ¹¹ ¹⁹ ⁵⁸ ³³

Extramedullary Myeloid Tumor ¹¹ ¹⁹ ⁵⁸

Myeloid Sarcoma Without Mention of Remission ³³

Myeloid Sarcoma Disease ³³

Sarcoma, Granulocytic ⁷⁵

Sarcoma Granulocytic ⁵³

Myeloid Sarcoma Nos ³³

Sarcoma, Myeloid ⁴³

Myelosarcoma ³³

Characteristics:

Prevelance:

<1/1000000 (Europe) ⁵⁸

Age Of Onset:

All ages ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³¹ ³²

Neoplasms

Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue

Myeloid leukaemia

Myeloid sarcoma

ICD11: ³³

Neoplasms

Neoplasms of haematopoietic or lymphoid tissues

Acute myeloid leukaemias and related precursor neoplasms

Acute myeloid leukaemia, not elsewhere classified by criteria of other types

Myeloid sarcoma

Orphanet: ⁵⁸

Rare haematological diseases

External Ids:

Disease Ontology ¹¹ DOID:8683

MeSH ⁴³ D023981

NCIt ⁴⁹ C35815

SNOMED-CT ⁶⁸ 188738007

ICD10 ³¹ C92.3

MESH via Orphanet ⁴⁴ D023981

ICD10 via Orphanet ³² C92.3

UMLS via Orphanet ⁷² C0152276

Orphanet ⁵⁸ ORPHA86850

EFO ¹⁶ EFO_1000286 EFO_1001052

ICD11 ³³ 1988933820

UMLS ⁷¹ C0152276

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Summaries for Myeloid Sarcoma

GARD: ¹⁹ Myeloid sarcoma is a rare solid tumor of the myelogenous cells occurring in an extramedullary site.

MalaCards based summary: Myeloid Sarcoma, also known as granulocytic sarcoma, is related to acute myelomonocytic leukemia and acute myeloid leukemia with t(8;21)(q22;q22) translocation. An important gene associated with Myeloid Sarcoma is MPO (Myeloperoxidase), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. The drugs Etoposide and Asparaginase Escherichia coli have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and bone, and related phenotypes are immune system and neoplasm

Orphanet: ⁵⁸ Myeloid sarcoma is a rare solid tumor of the myelogenous cells occurring in an extramedullary site.

Wikipedia: ⁷⁵ A myeloid sarcoma (chloroma, granulocytic sarcoma,: 744 extramedullary myeloid tumor) is a solid tumor... more...

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Related Diseases for Myeloid Sarcoma

Diseases related to Myeloid Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 630)

#	Related Disease	Score	Top Affiliating Genes
1	acute myelomonocytic leukemia	31.8	MPO KMT2A KIT FLT3 DNTT
2	acute myeloid leukemia with t(8;21)(q22;q22) translocation	31.8	RUNX1T1 KIT FLT3
3	acute myeloblastic leukemia with maturation	30.7	NPM1 KIT FLT3
4	myeloproliferative neoplasm	30.7	U2AF1 MPO KMT2A KIT FLT3 CD34
5	essential thrombocythemia	30.4	U2AF1 KIT FLT3 CD34
6	acute myeloblastic leukemia without maturation	30.4	NPM1 FLT3
7	mastocytosis	30.3	TNFRSF8 KIT FLT3
8	mast cell neoplasm	30.3	U2AF1 KIT FLT3
9	orbital cancer	30.3	NCAM1 CD68 CD34
10	embryonal rhabdomyosarcoma	30.2	PTPRC NCAM1 CD34
11	thymus cancer	30.2	PTPRC KIT DNTT
12	aplastic anemia	30.1	U2AF1 MPO FLT3 CD34
13	myelofibrosis	30.1	U2AF1 NPM1 MPO KIT FLT3 CD34
14	jejunal neoplasm	30.1	KIT CD34
15	polycythemia vera	30.1	U2AF1 PTPRC MPO KIT
16	myelophthisic anemia	30.1	U2AF1 CD34 ANPEP
17	myeloid leukemia	30.1	U2AF1 RUNX1T1 NPM1 NCAM1 MPO KMT2A
18	acute erythroid leukemia	30.1	U2AF1 KIT FLT3 CD34
19	chronic eosinophilic leukemia	30.1	U2AF1 KIT FLT3
20	histiocytosis	30.1	U2AF1 TNFRSF8 PTPRC
21	breast sarcoma	30.0	KIT CD34
22	childhood acute lymphocytic leukemia	30.0	KMT2A FLT3 ANPEP
23	breast malignant phyllodes tumor	30.0	KIT CD34
24	anaplastic large cell lymphoma	30.0	TNFRSF8 PTPRC NPM1
25	vagina sarcoma	30.0	KIT CD34
26	myelodysplastic/myeloproliferative neoplasm	29.9	U2AF1 NPM1 KIT FLT3 CD34
27	connective tissue benign neoplasm	29.9	KIT CD68 CD34
28	orbital disease	29.9	NCAM1 MPO CD68 CD34
29	chronic lymphocytic leukemia/small lymphocytic lymphoma	29.9	TNFRSF8 SPN CD79A
30	lymphoma, hodgkin, classic	29.9	TNFRSF8 PTPRC IRF4 CD68
31	mastocytosis, cutaneous	29.8	U2AF1 TNFRSF8 KIT CD34
32	meninges sarcoma	29.8	IRF4 CD34
33	lymphoplasmacytic lymphoma	29.8	SPN IRF4 CD79A
34	fibrosarcoma of bone	29.7	TNFRSF8 CD79A CD68
35	langerhans cell histiocytosis	29.7	U2AF1 TNFRSF8 CD68 CD34
36	leukemia, acute monocytic	29.7	U2AF1 MPO KMT2A FLT3 CD33
37	leukemia	29.7	U2AF1 RUNX1T1 NPM1 KMT2A KIT FLT3
38	chronic myelomonocytic leukemia	29.6	U2AF1 NPM1 MPO KIT FLT3 CD34
39	aleukemic leukemia cutis	29.6	SPN NPM1 MPO CD34 ANPEP
40	germ cell cancer	29.6	TNFRSF8 KIT FUT4 CD34
41	lymphoblastic lymphoma	29.5	TNFRSF8 PTPRC MPO KMT2A DNTT CD7
42	hodgkin's lymphoma, nodular sclerosis	29.5	TNFRSF8 FUT4 CD79A
43	core binding factor acute myeloid leukemia	29.5	U2AF1 RUNX1T1 NPM1 KIT FLT3
44	lymphoma	29.5	TNFRSF8 PTPRC NPM1 IRF4 DNTT ANPEP
45	childhood acute myeloid leukemia	29.5	U2AF1 RUNX1T1 NPM1 KMT2A KIT FLT3
46	ewing sarcoma	29.5	TNFRSF8 PTPRC NCAM1 KIT DNTT
47	peripheral t-cell lymphoma	29.5	TNFRSF8 PTPRC NCAM1 CD7
48	plasmacytoma	29.4	PTPRC NCAM1 IRF4 CD79A
49	central nervous system leukemia	29.4	KMT2A CD7 CD34 CD33 ANPEP
50	diffuse large b-cell lymphoma	29.3	U2AF1 TNFRSF8 IRF4 CD79A

Graphical network of the top 20 diseases related to Myeloid Sarcoma:

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Symptoms & Phenotypes for Myeloid Sarcoma

GenomeRNAi Phenotypes related to Myeloid Sarcoma according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.19	ANPEP CD33 CD34 CD68 CD7 CD79A
2	no effect	GR00402-S-2	10.19	ANPEP CD34 CD68 CD7 CD79A DNTT

MGI Mouse Phenotypes related to Myeloid Sarcoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.91	ANPEP CD33 CD34 CD68 CD7 CD79A
2	neoplasm	MP:0002006	9.85	CD34 CD79A FLT3 IRF4 KIT KMT2A
3	hematopoietic system	MP:0005397	9.58	ANPEP CD33 CD34 CD68 CD7 CD79A

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Drugs & Therapeutics for Myeloid Sarcoma

Drugs for Myeloid Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 88)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Etoposide

Approved

Phase 3

33419-42-0

36462

Asparaginase Escherichia coli

Approved, Investigational

Phase 3

9015-68-3

Picropodophyllin

Approved, Investigational

Phase 3

518-28-5, 477-47-4

10607 72435

Sorafenib

Approved, Investigational

Phase 3

284461-73-0

216239

Bortezomib

Approved, Investigational

Phase 3

179324-69-7

387447 93860

Daunorubicin

Approved

Phase 3

20830-81-3

30323

Mitoxantrone

Approved, Investigational

Phase 3

70476-82-3, 65271-80-9

4212

Aspartic acid

Approved, Nutraceutical

Phase 3

56-84-8

5960

Asparagine

Approved, Investigational, Nutraceutical

Phase 3

70-47-3

6267

Analgesics

Phase 3

Antimitotic Agents

Phase 3

Etoposide phosphate

Phase 3

16760419

Keratolytic Agents

Phase 3

Tubulin Modulators

Phase 3

N-Methylaspartate

Phase 3

Dermatologic Agents

Phase 3

Protein Kinase Inhibitors

Phase 3

Blinatumomab

Approved, Investigational

Phase 2

853426-35-4

Sirolimus

Approved, Investigational

Phase 2

53123-88-9

5284616 6436030

Coenzyme M

Approved, Investigational

Phase 2

3375-50-6

598 23662354

Miconazole

Approved, Investigational, Vet_approved

Phase 2

22916-47-8

4189

Clotrimazole

Approved, Vet_approved

Phase 2

23593-75-1

2812

Idarubicin

Approved

Phase 2

58957-92-9

42890

Cladribine

Approved, Investigational

Phase 2

4291-63-8

20279

Dexrazoxane

Approved, Withdrawn

Phase 2

24584-09-6

71384

Cytarabine

Approved, Investigational

Phase 2

147-94-4

6253

Melphalan

Approved

Phase 2

148-82-3

4053 460612

Rituximab

Approved

Phase 2

174722-31-7

Fludarabine

Approved

Phase 2

75607-67-9, 21679-14-1

30751 657237

Lenograstim

Approved, Investigational

Phase 2

135968-09-1

Cyclophosphamide

Approved, Investigational

Phase 2

50-18-0, 6055-19-2

2907

Thiotepa

Approved, Investigational

Phase 2

52-24-4

5453

Tacrolimus

Approved, Investigational

Phase 2

104987-11-3

6473866 445643

Mechlorethamine

Approved, Investigational

Phase 2

51-75-2

4033

Aldesleukin

Approved

Phase 2

110942-02-4

Mycophenolic acid

Approved, Investigational

Phase 2

24280-93-1

446541

Busulfan

Approved, Investigational

Phase 2

55-98-1

2478

Vidarabine

Approved, Investigational

Phase 2

24356-66-9

21704

Plerixafor

Approved

Phase 2

110078-46-1

65015

Clofarabine

Approved, Investigational

Phase 2

123318-82-1

119182

Folic acid

Approved, Nutraceutical, Vet_approved

Phase 2

59-30-3

6037

Lipoic acid

Approved, Investigational, Nutraceutical

Phase 2

1200-22-2

864 6112

D-Phenylalanine

Approved, Experimental, Investigational, Nutraceutical

Phase 2

63-91-2, 673-06-3

6140 71567

Cordycepin

Investigational

Phase 2

73-03-0

248010

Antifungal Agents

Phase 2

Cardiotonic Agents

Phase 2

Razoxane

Phase 2

Immunoglobulins

Phase 2

2'-deoxyadenosine

Phase 2

2-chloro-3'-deoxyadenosine

Phase 2

14485373

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Phase III Randomized Trial for Patients With De Novo AML Using Bortezomib and Sorafenib (NSC# 681239, NSC# 724772) for Patients With High Allelic Ratio FLT3/ITD	Active, not recruiting	NCT01371981	Phase 3	Asparaginase;Bortezomib;Cytarabine;Daunorubicin Hydrochloride;Etoposide;Mitoxantrone Hydrochloride;Sorafenib Tosylate
2	Provision of TCRγδ T Cells and Memory T Cells Plus Selected Use of Blinatumomab in Naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies Relapsed or Refractory Despite Prior Transplantation	Recruiting	NCT02790515	Phase 2	Anti-thymocyte globulin (rabbit);Blinatumomab;Cyclophosphamide;Fludarabine;G-CSF;Melphalan;Mesna;Rituximab;Tacrolimus;Thiotepa;Sirolimus
3	Cardioprotection With Dexrazoxane in Acute Myeloid Leukemia (AML), High-Risk Myelodysplastic Syndrome (MDS), Myeloid Blast Phase of Chronic Myeloid Leukemia (CML), Ph+ AML, and Myeloid Blast Phase of Myeloproliferative Neoplasms	Recruiting	NCT03589729	Phase 2	Cladribine;Cytarabine;Dexrazoxane Hydrochloride;Gemtuzumab Ozogamicin;Idarubicin
4	Phase II Trial of Vosaroxin in Combination With Infusional Cytarabine in Patients With Untreated AML	Active, not recruiting	NCT02658487	Phase 2	Cytarabine;Vosaroxin
5	An Open Label Study to Evaluate the Feasibility of CPI-613 Given With High Dose Cytarabine and Mitoxantrone in Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML)	Active, not recruiting	NCT02484391	Phase 2	6,8-Bis(benzylthio)octanoic Acid;Cytarabine;Mitoxantrone Hydrochloride
6	CD45A-Depleted Haploidentical Hematopoietic Progenitor Cell and Natural Killer Cell Transplantation for Hematologic Malignancies Relapsed or Refractory Despite Prior Transplantation	Terminated	NCT02259348	Phase 2	Cyclophosphamide;Fludarabine;Melphalan;Thiotepa;Rituximab
7	T-Cell Replete Haploidentical Donor Hematopoietic Stem Cell Plus Natural Killer (NK) Cell Transplantation in Patients With Hematologic Malignancies Relapsed or Refractory Despite Previous Allogeneic Transplant	Terminated	NCT01621477	Phase 2	clofarabine;cytarabine;busulfan;Plerixafor;cyclophosphamide;antithymocyte globulin (rabbit);Tacrolimus;mycophenolate mofetil
8	A Pilot Study of Allogeneic Hematopoietic Cell Transplantation for Patients With High Grade Central Nervous System Malignancies	Recruiting	NCT04521946	Phase 1	Etoposide;Fludarabine Phosphate;Melphalan;Mycophenolate Mofetil;Tacrolimus;Thiotepa

Search NIH Clinical Center for Myeloid Sarcoma

Cochrane evidence based reviews: sarcoma, myeloid

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Genetic Tests for Myeloid Sarcoma

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Anatomical Context for Myeloid Sarcoma

Organs/tissues related to Myeloid Sarcoma:

MalaCards : Myeloid, Bone Marrow, Bone, T Cells, Breast, Spinal Cord, Small Intestine

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Publications for Myeloid Sarcoma

Articles related to Myeloid Sarcoma:

(show top 50) (show all 2397)

#	Title	Authors	PMID	Year
1	The expression of myeloid antigens CD13 and/or CD33 is a marker of ALK+ anaplastic large cell lymphomas. ⁵³ ⁶²	Bovio IM...Allan RW	18794057	2008
2	Preceding orbital granulocytic sarcoma in an adult patient with acute myelogenous leukemia with t(8;21): a case study and review of the literature. ⁵³ ⁶²	Lee SG...Choi JR	18656695	2008
3	t(5;12)(q13;p13) in acute myeloid leukemia with preceding granulocytic sarcoma. ⁵³ ⁶²	Park TS...Choi JR	17854675	2007
4	Myeloid sarcoma presenting with acute renal failure and bilateral ureteral obstruction: a case report and review of the literature. ⁵³ ⁶²	Usmani SZ...Nasser KA	17700206	2007
5	Granulocytic sarcoma of breast: an aleukemic presentation. ⁵³ ⁶²	D'Costa GF...Patil YV	17337816	2007
6	Myeloid sarcoma occurring concurrently with drug-induced gingival enlargement. ⁵³ ⁶²	Yoon AJ...Zegarelli DJ	16579712	2006
7	Rearrangement of MLL in a patient with congenital acute monoblastic leukemia and granulocytic sarcoma associated with a t(1;11)(p36;q23) translocation. ⁵³ ⁶²	Douet-Guilbert N...De Braekeleer M	15621793	2005
8	[A-leukemic caecal myeloid sarcoma: a difficult diagnosis]. ⁵³ ⁶²	Nollevaux MC...Theate I	15738870	2004
9	FLT3 mutations in myeloid sarcoma. ⁵³ ⁶²	Ansari-Lari MA...Murphy KM	15352981	2004
10	Extramedullary presentation of acute leukaemia: a case of myeloid/natural killer cell precursor leukaemia. ⁵³ ⁶²	Chen VM...Ward C	12959763	2003
11	Granulocytic sarcoma in MLL-positive infant acute myelogenous leukemia: fluorescence in situ hybridization study of childhood acute myelogenous leukemia for detecting MLL rearrangement. ⁵³ ⁶²	Park KU...Cho HI	11733351	2001
12	c-Kit (CD117) reactivity in extramedullary myeloid tumor/granulocytic sarcoma. ⁵³ ⁶²	Chen J...Aguilera NS	11698000	2001
13	The value of CD34, myeloperoxidase and chloroacetate esterase (Leder) stain in the diagnosis of granulocytic sarcoma. ⁵³ ⁶²	Mourad W...Al Husseini H	17261930	2001
14	[Granulocytic sarcoma presenting as an epidural mass with spinal cord compression]. ⁵³ ⁶²	Machii R...Katsumata Y	11020993	2000
15	CD30+ anaplastic large-cell lymphoma with aberrant expression of CD13: case report and review of the literature. ⁵³ ⁶²	Dunphy CH...Taysi K	11138613	2000
16	Immunohistochemical characterization of mast cell disease in paraffin sections using tryptase, CD68, myeloperoxidase, lysozyme, and CD20 antibodies. ⁵³ ⁶²	Li WV...Swerdlow SH	8902835	1996
17	Granulocytic sarcoma with expression of CD30. ⁵³ ⁶²	Fickers M...Theunissen P	9038763	1996
18	Extramedullary myeloid cell tumors in myelodysplastic-syndromes: not a true indication of impending acute myeloid leukemia. ⁵³ ⁶²	Byrd JC...Dawson N	8907283	1996
19	Extramedullary tumors of lymphoid or myeloid blasts. The role of immunohistology in diagnosis and classification. ⁵³ ⁶²	Quintanilla-Martinez L...Harris NL	7572794	1995
20	Myelodysplastic syndrome presenting with generalized cutaneous granulocytic sarcomas. ⁵³ ⁶²	Lin CK...Liu HW	2154905	1990
21	Immunohistochemical differential diagnosis of granulocytic sarcomas and malignant lymphomas on formalin-fixed material. ⁵³ ⁶²	Fellbaum C...Hansmann ML	2106752	1990
22	18 F-FDG PET/CT Findings of Myeloid Sarcoma Involving the Left Ventricle and Kidney in a Pediatric Patient. ⁶²	Zhang M...Yang J	36179330	2023
23	Breast manifestation of extramedullary myeloid sarcoma: A case report. ⁶²	Naamo S...Froicu M	36204411	2022
24	Acute subdural hematoma due to acute myeloid leukemia and B-cell lymphoma. ⁶²	Babici D...Hanafy K	36164337	2022
25	Myeloid sarcoma mimicking suprasellar meningioma in acute promyelocytic leukaemia. ⁶²	Hartzell C...Bains A	35249746	2022
26	Cytochrome P450 inhibition to decrease dosage and costs of venetoclax and ibrutinib: A proof-of-concept case study. ⁶²	De la Garza-Salazar F...Gomez-Almaguer D	36354135	2022
27	Myeloid Sarcoma: Features in Cytological Preparations and the Utility of Rapid On-Site Evaluation (ROSE) in Triage. ⁶²	Tariq H...Cheng L	36318898	2022
28	Molecular annotation of extramedullary acute myeloid leukemia identifies high prevalence of targetable mutations. ⁶²	Ball S...Sallman DA	36107670	2022
29	Successful Treatment of Pediatric Acute Myeloid Leukemia Presenting with Hyperbilirubinemia Secondary to Myeloid Sarcoma: A Case Report. ⁶²	Shash HA...Khairy AM	36360428	2022
30	Granulocytic sarcoma with long spinal cord compression: A case report. ⁶²	Shao YD...Cui XG	36387816	2022
31	[Isolated myeloid sarcoma of the cervix: a clinicopathological analysis of three cases]. ⁶²	Xu C...Wang C	36323550	2022
32	Myeloid sarcoma: "A cytological surprise". ⁶²	Jindal A...Shergill JS	35960136	2022
33	Myeloid sarcoma with ulnar nerve entrapment: A case report. ⁶²	Li DP...Zhou Y	36246824	2022
34	Isolated myeloid sarcoma with pericardial and pleural effusions as first manifestation: A case report. ⁶²	Deng K...Ju W	36281103	2022
35	[Clinical Efficacy and Survival Analysis of Adult Patients with Acute Myeloid Leukemia after Microtransplantation]. ⁶²	Huang YJ...Yang LH	36208236	2022
36	TCL-525 Salivary Myeloid Sarcoma: A Challenging Diagnosis. ⁶²	Grain M...Siala I	36164135	2022
37	Myeloid sarcoma arising at the uterine cervix in a patient with intestinal Behçet's disease and concurrent myelodysplastic syndrome: A case report. ⁶²	Choi HY...Park JW	36316914	2022
38	A clinical report of intracranial granulocytic sarcoma and a literature review. ⁶²	Cheng H...Jiang X	33272089	2022
39	Serial Analysis and Comparison of Mutation Profiles in Decitabine-treated Myeloid Sarcoma and Subsequent Acute Myeloid Leukemia Using Next-Generation Sequencing. ⁶²	Park HS...Kwon J	35470279	2022
40	A Novel USP25::PDGFRA Gene Fusion in a 78 Year Old Patient with a Myeloid Neoplasm. ⁶²	Dalland JC...Peterson JF	35217871	2022
41	Presentation of Chloromas in B-Mode Ultrasound and Contrast-Enhanced Ultrasound. ⁶²	Trenker C...Safai Zadeh E	35778304	2022
42	Identification of RCC1-LCK as a novel fusion gene in pediatric erythroid sarcoma. ⁶²	Oya S...Iehara T	35714314	2022
43	A ZBTB16-RARα Variant of Acute Promyelocytic Leukemia with Concurrent Myeloid Sarcoma Presenting as Sudden Onset Paraplegia. ⁶²	Cho EJ...Jung JY	36125151	2022
44	Myeloid/lymphoid neoplasm with eosinophilia and rearrangement of PDGFRA presenting as myeloid sarcoma. ⁶²	Barouqa M...McPhail ED	36051048	2022
45	Isolated leukemia cutis as extramedullary relapse of acute myeloid leukemia. ⁶²	Dadrass F...Hossain NM	35949412	2022
46	Myeloid sarcoma of the breast as a first manifestation of acute myeloid leukemia: A case report. ⁶²	Ding Y...Gu W	35414450	2022
47	Clinicopathological characteristics, genetics and prognosis of patients with myeloid sarcoma: a single-center study. ⁶²	Demir D...Ozsan N	35927017	2022
48	Vulvovaginal myeloid sarcoma with massive pelvic floor infiltration: A case report and review of literature. ⁶²	Wang JX...Bao L	36159511	2022
49	The characteristics and prognostic significance of the SET-CAN/NUP214 fusion gene in hematological malignancies: A systematic review. ⁶²	Wang J...Zhang HY	35905214	2022
50	Bilateral Orbital Myeloid Sarcomas: A Unique Presentation of Acute Myeloid Leukemia. ⁶²	Stephenson SG...Figarola MS	36051742	2022

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Genes for Myeloid Sarcoma

Genes related to Myeloid Sarcoma (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	MPO	Myeloperoxidase	Protein Coding	25.16	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9038763 15738870 17700206 (more) 11020993 12959763 8902835 17854675 2154905 16579712 17261930 8037168 11419984 17337816 18656695
2	FLT3	Fms Related Receptor Tyrosine Kinase 3	Protein Coding	17.91	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15352981
3	DNTT	DNA Nucleotidylexotransferase	Protein Coding	15.3	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	7572794
4	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	15.08	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	8037168 17700206 2106752
5	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	13.58	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11698000
6	ANPEP	Alanyl Aminopeptidase, Membrane	Protein Coding	13.21	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	18794057 11138613
7	KMT2A	Lysine Methyltransferase 2A	Protein Coding	11.94	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11733351 15621793
8	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	10.76	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	8907283
9	U2AF1	U2 Small Nuclear RNA Auxiliary Factor 1	Protein Coding	8.31	DISEASES inferred ¹⁴ ¹⁴
10	SPN	Sialophorin	Protein Coding	7.85	DISEASES inferred ¹⁴
11	CD34	CD34 Molecule	Protein Coding	7.58	DISEASES inferred ¹⁴
12	CD33	CD33 Molecule	Protein Coding	7.5	DISEASES inferred ¹⁴
13	CD68	CD68 Molecule	Protein Coding	7.27	DISEASES inferred ¹⁴
14	NPM1	Nucleophosmin 1	Protein Coding	7	DISEASES inferred ¹⁴
15	CD79A	CD79a Molecule	Protein Coding	6.8	DISEASES inferred ¹⁴
16	FUT4	Fucosyltransferase 4	Protein Coding	6.61	DISEASES inferred ¹⁴
17	TNFRSF8	TNF Receptor Superfamily Member 8	Protein Coding	6.6	DISEASES inferred ¹⁴
18	CD7	CD7 Molecule	Protein Coding	6.58	DISEASES inferred ¹⁴
19	IRF4	Interferon Regulatory Factor 4	Protein Coding	6.53	DISEASES inferred ¹⁴ ¹⁴
20	RUNX1T1	RUNX1 Partner Transcriptional Co-Repressor 1	Protein Coding	6.5	DISEASES inferred ¹⁴

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Variations for Myeloid Sarcoma

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Expression for Myeloid Sarcoma

Search GEO for disease gene expression data for Myeloid Sarcoma.

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Pathways for Myeloid Sarcoma

Pathways related to Myeloid Sarcoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.7	TNFRSF8 PTPRC NCAM1 MPO IRF4 FLT3
2	NF-kappaB Signaling ³	12.32	TNFRSF8 RUNX1T1 PTPRC NCAM1 MPO KIT
3	Mesenchymal Stem Cells and Lineage-specific Markers ⁶⁵	11.7	PTPRC NCAM1 KIT CD79A CD34
4	Innate Lymphoid Cells Differentiation ⁶⁵	11.64	CD34 CD7 IRF4 KIT NCAM1 PTPRC
5	C-MYB transcription factor network ⁶¹	11.57	MPO KIT CD34 ANPEP
6	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.48	PTPRC IRF4 CD79A
7	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.43	SPN PTPRC NCAM1 MPO KIT FLT3
8	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.37	SPN PTPRC NCAM1 KIT IRF4 FLT3
9	Cardiac progenitor differentiation ⁷⁴	11.33	NCAM1 KIT ANPEP
10	LDL Oxidation in Atherogenesis ⁶⁴	10.68	MPO CD68

Sources

GO Terms for Myeloid Sarcoma

Cellular components related to Myeloid Sarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	membrane	GO:0016020	10.16	ANPEP CD33 CD34 CD68 CD7 CD79A
2	membrane	GO:0016021	10.16	ANPEP CD33 CD34 CD68 CD7 CD79A
3	external side of plasma membrane	GO:0009897	9.53	SPN PTPRC NCAM1 KIT CD79A CD34

Biological processes related to Myeloid Sarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	T cell activation	GO:0042110	9.8	PTPRC IRF4 CD7
2	myeloid progenitor cell differentiation	GO:0002318	9.46	KIT FLT3
3	positive regulation of response to stimulus	GO:0048584	9.37	KIT FLT3
4	positive regulation of protein modification process	GO:0031401	9.26	KIT FLT3
5	positive regulation of protein tyrosine phosphatase activity	GO:1903615	9.26	PTPRC CD33
6	B cell differentiation	GO:0030183	9.23	PTPRC KIT FLT3 CD79A