Myeloid Sarcoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MYL003 MIFTS: 51	Myeloid Sarcoma Categories: Rare diseases, Cancer diseases, Blood diseases, Immune diseases
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Aliases & Classifications for Myeloid Sarcoma

MalaCards integrated aliases for Myeloid Sarcoma:

Name: Myeloid Sarcoma ¹² ⁵³ ⁵⁹ ¹⁵

Granulocytic Sarcoma ¹² ⁵³ ⁵⁹ ⁷³

Extramedullary Myeloid Tumor ¹² ⁵³ ⁵⁹

Chloroma ¹² ⁵³ ⁵⁹

Sarcoma, Granulocytic ⁷⁶

Sarcoma Granulocytic ⁵⁵

Sarcoma, Myeloid ⁴⁴

Characteristics:

Orphanet epidemiological data:

⁵⁹

myeloid sarcoma
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Blood diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³³ ³⁴

Neoplasms

Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue

Myeloid leukaemia

Myeloid sarcoma

Orphanet: ⁵⁹

Rare haematological diseases

External Ids:

Disease Ontology ¹² DOID:8683

ICD10 ³³ C92.3 C92.30

ICD9CM ³⁵ 205.3

MeSH ⁴⁴ D023981

NCIt ⁵⁰ C3520 C35815

SNOMED-CT ⁶⁸ 188737002 188738007 188739004 more

Orphanet ⁵⁹ ORPHA86850

UMLS via Orphanet ⁷⁴ C0152276

MESH via Orphanet ⁴⁵ D023981

ICD10 via Orphanet ³⁴ C92.3

UMLS ⁷³ C0152276

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Summaries for Myeloid Sarcoma

NIH Rare Diseases : ⁵³ The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 86850Disease definitionMyeloid sarcoma is a rare solid tumor of the myelogenous cells occurring in an extramedullary site.EpidemiologyThe exact prevalence is unknown.Clinical descriptionThe clinical presentation depends on the site of involvement. Commonly involved sites of occurrence include the subperiosteal bone structures of the skull, paranasal sinuses, sternum, ribs, vertebrae, pelvis, as well as the lymph nodes and skin. Rare sites include the pancreas, heart, brain, mouth, breast, gastrointestinal and biliary tract, prostate, urinary bladder and gynecologic tract.Visit the Orphanet disease page for more resources.

MalaCards based summary : Myeloid Sarcoma, also known as granulocytic sarcoma, is related to myeloid leukemia and blastic plasmacytoid dendritic cell. An important gene associated with Myeloid Sarcoma is MPO (Myeloperoxidase), and among its related pathways/superpathways are NF-kappaB Signaling and Transcriptional misregulation in cancer. The drugs Lenograstim and Fludarabine have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : ⁷⁶ A myeloid sarcoma (chloroma, granulocytic sarcoma,extramedullary myeloid tumor), is a solid tumor... more...

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Related Diseases for Myeloid Sarcoma

Diseases related to Myeloid Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 137)

#	Related Disease	Score	Top Affiliating Genes
1	myeloid leukemia	30.2	FLT3 KIT NPM1
2	blastic plasmacytoid dendritic cell	29.8	NCAM1 NPM1
3	dendritic cell tumor	29.7	DNTT MPO PTPRC
4	acute biphenotypic leukemia	29.1	DNTT KMT2A MPO
5	chronic myelomonocytic leukemia	28.7	FLT3 KIT
6	lymphoblastic lymphoma	28.5	DNTT KMT2A MPO PTPRC
7	leukemia, acute lymphoblastic	28.2	DNTT FLT3 KMT2A PAX5
8	leukemia, chronic myeloid	27.9	DNTT FLT3 KIT KMT2A MPO
9	acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	27.7	DNTT FLT3 KIT KMT2A MPO
10	acute promyelocytic leukemia	27.4	ANPEP FLT3 MPO NCAM1 NPM1 PTPRC
11	myelodysplastic syndrome	27.0	ANPEP DNTT FLT3 KIT KMT2A NPM1
12	acute leukemia	25.9	ANPEP DNTT FLT3 KIT KMT2A MPO
13	leukemia, acute myeloid	25.3	ANPEP DNTT FLT3 KIT KMT2A MPO
14	sarcoma	10.9
15	acute myeloid leukemia with minimal differentiation	10.7	FLT3 MPO
16	acute myeloblastic leukemia without maturation	10.6	FLT3 NPM1
17	leukemia	10.5
18	chronic monocytic leukemia	10.5	MPO PTPRC
19	primary cutaneous anaplastic large cell lymphoma	10.5	NPM1 PTPRC
20	photokeratitis	10.4	DNTT PTPRC
21	epidural neoplasm	10.4	DNTT PTPRC
22	nodular lymphocyte predominant hodgkin lymphoma	10.4	PAX5 PTPRC
23	acute myeloid leukemia with t(8;21)(q22;q22) translocation	10.4	FLT3 KIT
24	hodgkin's lymphoma, lymphocytic depletion	10.4	PAX5 PTPRC
25	lymphatic system cancer	10.4	NPM1 PTPRC
26	tetrasomy 21	10.3	ANPEP DNTT
27	malignant leydig cell tumor	10.3	KIT PAX5
28	chronic eosinophilic leukemia	10.3	FLT3 KIT
29	extracutaneous mastocytoma	10.3	KIT PTPRC
30	diffuse cutaneous mastocytosis	10.3	KIT PTPRC
31	sarcomatoid squamous cell skin carcinoma	10.3	KIT PTPRC
32	8p11 myeloproliferative syndrome	10.3	FLT3 KIT
33	conventional fibrosarcoma	10.2	KIT PTPRC
34	testicular infarct	10.2	KIT PTPRC
35	gastric small cell carcinoma	10.2	NCAM1 PTPRC
36	pediatric lymphoma	10.2	DNTT NCAM1
37	cutaneous ganglioneuroma	10.2	KIT NCAM1
38	core binding factor acute myeloid leukemia	10.2	FLT3 KIT
39	angiomyoma	10.1	KIT NCAM1
40	plasma cell neoplasm	10.1	NCAM1 PTPRC
41	perineurioma	10.1	KIT NCAM1
42	rete testis neoplasm	10.1	KIT NCAM1
43	multiple cranial nerve palsy	10.1	MPO NCAM1
44	neurofibromatosis, type i	10.1	KIT NCAM1
45	malignant skin fibrous histiocytoma	10.1	KIT NCAM1
46	lung lymphoma	10.0	NCAM1 PAX5
47	acute myeloblastic leukemia with maturation	10.0	FLT3 KIT NPM1
48	anaplastic large cell lymphoma	10.0	NPM1 PAX5 PTPRC
49	large cell neuroendocrine carcinoma	10.0	KIT NCAM1
50	mn1	10.0	FLT3 KMT2A

Graphical network of the top 20 diseases related to Myeloid Sarcoma:

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Symptoms & Phenotypes for Myeloid Sarcoma

GenomeRNAi Phenotypes related to Myeloid Sarcoma according to GeneCards Suite gene sharing:

²⁶ (show all 32)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-100	10.07	MPO
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-102	10.07	KIT DNTT FLT3
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-115	10.07	FLT3
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-116	10.07	FLT3
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-120	10.07	FLT3
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-121	10.07	FLT3
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-122	10.07	FLT3
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-123	10.07	FLT3 DNTT
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-126	10.07	MPO
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-138	10.07	DNTT
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-151	10.07	DNTT
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-152	10.07	KIT
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-157	10.07	MPO DNTT KIT
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-16	10.07	DNTT
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-163	10.07	FLT3
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-170	10.07	KIT
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-176	10.07	MPO
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-182	10.07	DNTT
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-186	10.07	MPO
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-197	10.07	DNTT
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-25	10.07	FLT3
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-29	10.07	MPO
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-30	10.07	KIT
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-36	10.07	MPO
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-42	10.07	KIT
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-57	10.07	MPO
27	Increased shRNA abundance (Z-score > 2)	GR00366-A-7	10.07	MPO
28	Increased shRNA abundance (Z-score > 2)	GR00366-A-70	10.07	MPO FLT3
29	Increased shRNA abundance (Z-score > 2)	GR00366-A-73	10.07	DNTT
30	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	10.07	KIT
31	Increased shRNA abundance (Z-score > 2)	GR00366-A-9	10.07	KIT
32	Increased shRNA abundance (Z-score > 2)	GR00366-A-99	10.07	KIT

MGI Mouse Phenotypes related to Myeloid Sarcoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.91	MPO NPM1 ANPEP PAX5 DNTT FLT3
2	cellular	MP:0005384	9.87	KMT2A NCAM1 NPM1 PAX5 FLT3 PTPRC
3	immune system	MP:0005387	9.81	MPO NPM1 ANPEP PAX5 DNTT FLT3
4	mortality/aging	MP:0010768	9.56	KMT2A MPO NCAM1 NPM1 PAX5 FLT3
5	neoplasm	MP:0002006	9.1	KMT2A NPM1 PAX5 FLT3 PTPRC KIT

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Drugs & Therapeutics for Myeloid Sarcoma

Drugs for Myeloid Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 98)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Lenograstim

Approved, Investigational

Phase 3,Phase 2,Phase 1

135968-09-1

Fludarabine

Approved

Phase 3,Phase 2,Phase 1

21679-14-1, 75607-67-9

30751

Etoposide

Approved

Phase 3

33419-42-0

36462

Hydrocortisone

Approved, Vet_approved

Phase 3

50-23-7

5754

Methotrexate

Approved

Phase 3

1959-05-2, 59-05-2

126941

Cytarabine

Approved, Investigational

Phase 3,Phase 2,Phase 1

147-94-4

6253

Cyclophosphamide

Approved, Investigational

Phase 3,Phase 2

50-18-0, 6055-19-2

2907

Dexamethasone

Approved, Investigational, Vet_approved

Phase 3

50-02-2

5743

Busulfan

Approved, Investigational

Phase 3

55-98-1

2478

Idarubicin

Approved

Phase 3

58957-92-9

42890

Daunorubicin

Approved

Phase 3

20830-81-3

30323

Thioguanine

Approved

Phase 3

154-42-7

2723601

Aldesleukin

Approved

Phase 3,Phase 2

85898-30-2, 110942-02-4

Darbepoetin alfa

Approved, Investigational

Phase 3

11096-26-7, 209810-58-2

Mitoxantrone

Approved, Investigational

Phase 3,Phase 2

65271-80-9

4212

Sorafenib

Approved, Investigational

Phase 3

284461-73-0

216239 406563

Bortezomib

Approved, Investigational

Phase 3

179324-69-7

387447 93860

leucovorin

Approved, Nutraceutical

Phase 3

58-05-9

143 6006

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 3

59-30-3

6037

Nicotinamide

Approved, Investigational, Nutraceutical

Phase 3

98-92-0

936

Niacin

Approved, Investigational, Nutraceutical

Phase 3

59-67-6

938

Butyric Acid

Experimental, Investigational

Phase 3

107-92-6

264

Dexamethasone acetate

Phase 3

1177-87-3

Interleukin-2

Phase 3,Phase 2

Imatinib Mesylate

Phase 3

220127-57-1

123596

Analgesics

Phase 3,Phase 2

Alkylating Agents

Phase 3,Phase 2

glucocorticoids

Phase 3

asparaginase

Phase 3

Folic Acid Antagonists

Phase 3

Gastrointestinal Agents

Phase 3

Cortisol succinate

Phase 3

Hematinics

Phase 3

Analgesics, Non-Narcotic

Phase 3,Phase 2

Topoisomerase Inhibitors

Phase 3,Phase 2

N-Methylaspartate

Phase 3

Hormone Antagonists

Phase 3

Dermatologic Agents

Phase 3

Nucleic Acid Synthesis Inhibitors

Phase 3

Hormones

Phase 3

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 3

Vidarabine Phosphate

Phase 3,Phase 1

Hydrocortisone 17-butyrate 21-propionate

Phase 3

Hydrocortisone acetate

Phase 3

Hydrocortisone-17-butyrate

Phase 3

Peripheral Nervous System Agents

Phase 3,Phase 2

Anti-Bacterial Agents

Phase 3,Phase 2

Vitamin B Complex

Phase 3

Antibiotics, Antitubercular

Phase 3,Phase 2

Etoposide phosphate

Phase 3

Interventional clinical trials:

(show all 12)

#	Name	Status	NCT ID	Phase	Drugs
1	Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome	Completed	NCT00002798	Phase 3	asparaginase;daunorubicin hydrochloride;fludarabine phosphate;therapeutic hydrocortisone;cytarabine;idarubicin;dexamethasone;thioguanine;etoposide;methotrexate;cyclophosphamide;busulfan
2	Compare Bosutinib To Imatinib In Subjects With Newly Diagnosed Chronic Phase Philadelphia Chromosome Positive CML	Completed	NCT00574873	Phase 3	Bosutinib;imatinib
3	Darbepoetin Alfa in Patients With Anemic Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS)	Completed	NCT01362140	Phase 3	Darbepoetin alfa;Placebo
4	Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia	Active, not recruiting	NCT01371981	Phase 3	Asparaginase;Bortezomib;Cytarabine;Daunorubicin Hydrochloride;Etoposide;Mitoxantrone Hydrochloride;Sorafenib Tosylate
5	CIP-613, Cytarabine, and Mitoxantrone Hydrochloride in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Granulocytic Sarcoma	Recruiting	NCT02484391	Phase 2	6,8-Bis(benzylthio)octanoic Acid;Cytarabine;Mitoxantrone Hydrochloride
6	MG4101 for Refractory or Relapsed AML	Recruiting	NCT03349502	Phase 2	MG4101
7	Provision of TCRγδ T Cells and Memory T Cells Plus Selected Use of Blinatumomab in Naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies Relapsed or Refractory Despite Prior Transplantation	Recruiting	NCT02790515	Phase 2	Anti-thymocyte globulin (rabbit);Blinatumomab;Cyclophosphamide;Fludarabine;G-CSF;Melphalan;Mesna;Rituximab;Tacrolimus;Thiotepa;Sirolimus
8	Vosaroxin and Infusional Cytarabine in Treating Patients With Untreated Acute Myeloid Leukemia	Recruiting	NCT02658487	Phase 2	Cytarabine;Vosaroxin
9	Repeat Transplantation for Relapsed or Refractory Hematologic Malignancies Following Prior Transplantation	Terminated	NCT02259348	Phase 2	Cyclophosphamide;Fludarabine;Melphalan;Thiotepa;Rituximab
10	Wee1 Kinase Inhibitor AZD1775 and Combination Chemotherapy in Treating Children, Adolescents and Young Adults With Relapsed or Refractory Acute Myeloid Leukemia	Withdrawn	NCT02791919	Phase 1	Cytarabine;Fludarabine Phosphate;WEE1 Inhibitor AZD1775
11	PET-CT in AML for Detection of Extramedullary AML Manifestations	Completed	NCT01278069
12	Central Nervous System (CNS) Involvement in Acute Myeloid Leukemia (AML)	Not yet recruiting	NCT03410407

Search NIH Clinical Center for Myeloid Sarcoma

Cochrane evidence based reviews: sarcoma, myeloid

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Genetic Tests for Myeloid Sarcoma

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Anatomical Context for Myeloid Sarcoma

MalaCards organs/tissues related to Myeloid Sarcoma:

⁴¹

Myeloid, Bone, Bone Marrow, Skin, Prostate, Lymph Node, Brain

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Publications for Myeloid Sarcoma

Articles related to Myeloid Sarcoma:

(show top 50) (show all 466)

#	Title	Authors	Year
1	RTK-RAS pathway mutation is enriched in myeloid sarcoma. ( 29789584 )	Choi M....Koh Y.	2018
2	Coexistent cutaneous myeloid sarcoma in a patient with invasive papillary carcinoma of thyroid - A rare presentation. ( 29855456 )	Tripathy S....Baisakh M.	2018
3	Activity of decitabine in pericardial myeloid sarcoma. ( 29779081 )	Evers D....van der Velden W.J.F.M.	2018
4	A Rare Case of Relapsed Pediatric Acute Promyelocytic Leukemia with Skin Involvement by Myeloid Sarcoma. ( 29650946 )	AraA_jo N.S....de Sousa Rodrigues C.F.	2018
5	A unique clinical presentation of de novo acute promyelocytic leukemia as a myeloid sarcoma of the breast. ( 29931624 )	Oravcova I....Drgona L.	2018
6	Intermediate dose cytarabine in treatment myeloid sarcoma of the bilateral breast after allogeneic stem cell transplantation: A case report and literature review. ( 29893346 )	Aznab M....Khazaie M.	2018
7	Detection of prognostically relevant mutations and translocations in myeloid sarcoma by next generation sequencing. ( 28633614 )	Kashofer K....Zebisch A.	2018
8	Loss of RKIP is a frequent event in myeloid sarcoma and promotes leukemic tissue infiltration. ( 29295844 )	Caraffini V....Zebisch A.	2018
9	Myeloid sarcoma involving the greater wing of the sphenoid bone and additional skeletal sites presenting with unilateral proptosis and fevers. ( 29557698 )	Wang J.C....Freitag S.K.	2018
10	Connecting the Dots: A Case of Myeloid Sarcoma. ( 29729239 )	Rose A....Brayer J.	2018
11	Myeloid Sarcoma Presented as Generalized Lymphadenopathy: Mimicking Malignant Lymphoma. ( 29398826 )	Gajendra S....Sachdev R.	2018
12	Expression of programmed death ligand 1 is associated with poor prognosis in myeloid sarcoma patients. ( 29602174 )	Kawamoto K....Ohshima K.	2018
13	Clinicopathological characteristics of de novo and secondary myeloid sarcoma: A monocentric retrospective study. ( 29532520 )	Claerhout H....Boeckx N.	2018
14	A Rare Cause of Paraplegia: Myeloid Sarcoma. ( 29393854 )	ArslantaA9 E....A9zdemir N.	2018
15	Peritoneal Myeloid Sarcoma in a Patient Treated for a Testicular Seminoma. ( 29955031 )	Longo R....Campitiello M.	2018
16	Clinical characteristics of pediatric patients with myeloid sarcoma without bone marrow involvement in Japan. ( 29971602 )	Taga T....Ishida Y.	2018
17	Primary Myeloid Sarcoma of the Prostate: A Case Report and Literature Review. ( 29854498 )	Nguyen R....Sayar H.	2018
18	Sacral Myeloid Sarcoma Manifesting as Radiculopathy in a Pediatric Patient: An Unusual Form of Myeloid Leukemia Relapse. ( 29888021 )	Rodrigues J.R....Carvalho S.	2018
19	Myeloid sarcoma of the small intestine in a patient without overt acute myeloid leukaemia: a challenging diagnosis of a rare condition. ( 29848520 )	NemAcsio R.A....Leite J.S.	2018
20	Myeloid sarcoma as a simulator of advanced ovarian cancer: A case report. ( 29666016 )	Capote S....Gil-Moreno A.	2018
21	Case Report of Myeloid Sarcoma Masquerading as In-Transit Metastasis at a Previous Melanoma Site: Avoiding a Diagnostic Pitfall. ( 29863571 )	Curry J.L....Gershenwald J.E.	2018
22	Myeloid Sarcoma Predicts Superior Outcome in Pediatric AML; Can Cytogenetics Solve the Puzzle? ( 29680411 )	Pramanik R....Bakhshi S.	2018
23	Isolated Pancreatic Myeloid Sarcoma Associated with t(8;21)/RUNX1-RUNX1T1 Rearrangement. ( 29151502 )	Tokunaga K....Okuno Y.	2018
24	Myeloid Sarcoma after Allogenic Stem Cell Transplantation for Acute Myeloid Leukemia: Successful Consolidation Treatment Approaches in Two Patients. ( 29682375 )	Johansen S....Reikvam H.	2018
25	Role of Positron Emission Tomography Imaging in Myeloid Sarcoma. ( 29430131 )	Sahu K.K....Thakur K.	2018
26	Myeloid sarcoma with megakaryoblastic differentiation presenting as a breast mass. ( 29684340 )	Obiorah I.E....Ozdemirli M.	2018
27	Extramedullary leukaemia presenting as cardiac myeloid sarcoma. ( 28513107 )	Peravali M....Afonso L.	2017
28	How Rare Is an Oral Presentation of Myeloid Sarcoma in the Infant? ( 28943463 )	Gaal A....Egbert M.	2017
29	Prostate Mass as a First Manifestation of Myeloid Sarcoma in a Patient With an Occult Acute Myeloid Leukemia-A Case Report. ( 28627396 )	Horvat N....Cesar Cavalcanti Viana P.	2017
30	Myeloid Sarcoma in a Patient with Myelodysplastic Syndrome Associated with del(5q-): Case Report and Literature Review. ( 28801374 )	Showalter J.A....Medeiros L.J.	2017
31	Clinical features and outcomes of extramedullary myeloid sarcoma in the United States: analysis using a national data set. ( 28841208 )	Goyal G....Go R.S.	2017
32	Primary myeloid sarcoma of small bowel. ( 28596206 )	Cicilet S....Biswas A.	2017
33	Clinical characteristics, molecular profile and outcomes of myeloid sarcoma: a single institution experience over 13 years. ( 28574302 )	Kaur V....Jethava Y.	2017
34	Extensive ulcerated lesions in a patient with cutaneous myeloid sarcoma responded to twice-daily fludarabine and cytarabine regimen. ( 28624256 )	Khan M....Naqvi K.	2017
35	A myeloid sarcoma involving the small intestine, kidneys, mesentery, and mesenteric lymph nodes: A case report and literature review. ( 29049187 )	Wang P....Wang B.	2017
36	Clinicoradiological characteristics, management and prognosis of primary myeloid sarcoma of the central nervous system: A report of four cases. ( 28927153 )	Yang B....Xu Y.	2017
37	Use of magnetic resonance imaging for diagnosis and after treatment of patients with myeloid sarcoma of the brain. ( 29254273 )	Hou X....Zhang X.	2017
38	Invasive Fungal Infection in Acute Myeloid Leukemia Associated with Myeloid Sarcoma of the Sinonasal Cavity: A Rare Case. ( 28607903 )	Vishwanath M....Pai M.R.	2017
39	Myeloid sarcoma: A clinicopathological study with emphasis on diagnostic difficulties. ( 29237964 )	Kudva R....Geetha V.	2017
40	Myeloid sarcoma identified on liquid-based cervical cytology samples: A report of two cases. ( 28569009 )	Snider J.S....Lindsey K.G.	2017
41	Myeloid sarcoma of the thyroid. ( 29236267 )	Goldenberg D....Cottrill E.E.	2017
42	Myeloid sarcoma causing airway obstruction. ( 28405080 )	Belknap A.R....Krause J.R.	2017
43	Isolated myeloid sarcoma of cervix: Aleukemic presentation. ( 29237986 )	Kamboj M....Pasricha S.	2017
44	Cutaneous myeloid sarcoma associated with chronic myeloid leukemia. ( 29267445 )	Vasconcelos E.R.A....Rochael M.C.	2017
45	Isolated myeloid sarcoma as the first manifestation of acute myeloid leukemia: a case study. ( 29152275 )	Mitkowski D....Gil L.	2017
46	Intracranial Myeloid Sarcoma Metastasis Mimicking Acute Subdural Hematoma. ( 29201484 )	Gill A.S....Ghostine S.	2017
47	Granulocytic Sarcoma of the Orbit Presenting as a Fulminant Orbitopathy in an Adult With Acute Myeloid Leukemia. ( 25853504 )	O'Neill J.P....Mokhtarzadeh A.	2017
48	Myeloid sarcoma of the oral cavity: A case report and review of 89 cases from the literature. ( 29075423 )	de Andrade B.A....RomaA+ach M.J.	2017
49	Myeloid sarcoma of the sigmoid colon: An unusual presentation of a rare condition. ( 28606757 )	El Hajj I.I....Shahda S.	2017
50	Successful 5-azacytidine treatment of myeloid sarcoma and leukemia cutis associated with myelodysplastic syndrome: A case report and literature review. ( 28885352 )	Katagiri T....Sone H.	2017

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Genes for Myeloid Sarcoma

Genes related to Myeloid Sarcoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	MPO	Myeloperoxidase	Protein Coding	34.59	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	9038763 15738870 17700206 (more) 11020993 12959763 8902835 17854675 2154905 16579712 17261930 8037168 11419984 17337816 18656695
2	FLT3	Fms Related Tyrosine Kinase 3	Protein Coding	25.49	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	15352981
3	PTPRC	Protein Tyrosine Phosphatase, Receptor Type C	Protein Coding	24.56	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	8037168 17700206 2106752
4	KIT	KIT Proto-Oncogene Receptor Tyrosine Kinase	Protein Coding	22.58	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	11698000
5	ANPEP	Alanyl Aminopeptidase, Membrane	Protein Coding	22.19	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	18794057 11138613
6	NPM1	Nucleophosmin 1	Protein Coding	21.7	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	KMT2A	Lysine Methyltransferase 2A	Protein Coding	20.67	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	11733351 15621793
8	DNTT	DNA Nucleotidylexotransferase	Protein Coding	20.64	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	7572794
9	PAX5	Paired Box 5	Protein Coding	20.2	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	19.53	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	8907283

Sources

Variations for Myeloid Sarcoma

Sources

Expression for Myeloid Sarcoma

Search GEO for disease gene expression data for Myeloid Sarcoma.

Sources

Pathways for Myeloid Sarcoma

Pathways related to Myeloid Sarcoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	NF-kappaB Signaling ⁴	12.28	KIT MPO NCAM1 PAX5 PTPRC
2	Transcriptional misregulation in cancer ³⁷	11.97	FLT3 KMT2A MPO PAX5
3	Tyrosine Kinases / Adaptors ⁴	11.82	FLT3 KIT NPM1
4	Hematopoietic cell lineage ³⁷	11.61	ANPEP DNTT FLT3 KIT
5	Innate Lymphoid Cell Differentiation Pathways ⁶⁵	11.54	KIT NCAM1 PTPRC
6	C-MYB transcription factor network ¹	11.45	ANPEP KIT MPO PAX5
7	Cardiac Progenitor Differentiation ¹	11.33	ANPEP KIT NCAM1
8	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.33	FLT3 KIT NCAM1 PTPRC
9	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.16	ANPEP FLT3 KIT MPO NCAM1 PTPRC
10	B Cell Development Pathways ⁶⁵	10.98	FLT3 KIT PAX5 PTPRC

Sources

GO Terms for Myeloid Sarcoma

Cellular components related to Myeloid Sarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	8.92	ANPEP KIT NCAM1 PTPRC

Biological processes related to Myeloid Sarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of apoptotic process	GO:0043066	9.46	FLT3 KIT MPO NPM1
2	visual learning	GO:0008542	9.37	KIT KMT2A
3	T cell differentiation	GO:0030217	9.32	KIT PTPRC
4	positive regulation of phosphatidylinositol 3-kinase activity	GO:0043552	9.26	FLT3 KIT
5	embryonic hemopoiesis	GO:0035162	8.96	KIT KMT2A
6	myeloid progenitor cell differentiation	GO:0002318	8.62	FLT3 KIT

Molecular functions related to Myeloid Sarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	growth factor binding	GO:0019838	8.62	FLT3 KIT

Sources

Sources for Myeloid Sarcoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia