Myeloid Sarcoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MYL003 MIFTS: 52	Myeloid Sarcoma Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases, Nephrological diseases, Rare diseases
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Aliases & Classifications for Myeloid Sarcoma

MalaCards integrated aliases for Myeloid Sarcoma:

Name: Myeloid Sarcoma ¹² ⁵³ ⁵⁹ ¹⁵

Granulocytic Sarcoma ¹² ⁵³ ⁵⁹ ⁷³

Extramedullary Myeloid Tumor ¹² ⁵³ ⁵⁹

Chloroma ¹² ⁵³ ⁵⁹

Sarcoma, Granulocytic ⁷⁶

Sarcoma Granulocytic ⁵⁵

Sarcoma, Myeloid ⁴⁴

Characteristics:

Orphanet epidemiological data:

⁵⁹

myeloid sarcoma
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Blood diseases Bone diseases Immune diseases Nephrological diseases

See all MalaCards categories (disease lists)

ICD10: ³³ ³⁴

Neoplasms

Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue

Myeloid leukaemia

Myeloid sarcoma

Orphanet: ⁵⁹

Rare haematological diseases

External Ids:

Disease Ontology ¹² DOID:8683

ICD10 ³³ C92.3 C92.30

ICD9CM ³⁵ 205.3

MeSH ⁴⁴ D023981

NCIt ⁵⁰ C3520 C35815

SNOMED-CT ⁶⁸ 35287006 94719007

Orphanet ⁵⁹ ORPHA86850

UMLS via Orphanet ⁷⁴ C0152276

MESH via Orphanet ⁴⁵ D023981

ICD10 via Orphanet ³⁴ C92.3

UMLS ⁷³ C0152276

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Summaries for Myeloid Sarcoma

NIH Rare Diseases : ⁵³ The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 86850Disease definitionMyeloid sarcoma is a rare solid tumor of the myelogenous cells occurring in an extramedullary site.EpidemiologyThe exact prevalence is unknown.Clinical descriptionThe clinical presentation depends on the site of involvement. Commonly involved sites of occurrence include the subperiosteal bone structures of the skull, paranasal sinuses, sternum, ribs, vertebrae, pelvis, as well as the lymph nodes and skin. Rare sites include the pancreas, heart, brain, mouth, breast, gastrointestinal and biliary tract, prostate, urinary bladder and gynecologic tract.Visit the Orphanet disease page for more resources.

MalaCards based summary : Myeloid Sarcoma, also known as granulocytic sarcoma, is related to myeloid leukemia and acute myeloblastic leukemia with maturation. An important gene associated with Myeloid Sarcoma is MPO (Myeloperoxidase), and among its related pathways/superpathways are NF-kappaB Signaling and Transcriptional misregulation in cancer. The drugs Fludarabine and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and breast, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : ⁷⁶ A myeloid sarcoma (chloroma, granulocytic sarcoma,extramedullary myeloid tumor), is a solid tumor... more...

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Related Diseases for Myeloid Sarcoma

Diseases related to Myeloid Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 209)

#	Related Disease	Score	Top Affiliating Genes
1	myeloid leukemia	30.9	FLT3 KIT NPM1
2	acute myeloblastic leukemia with maturation	30.0	FLT3 KIT NPM1
3	acute myeloid leukemia with t(8;21)(q22;q22) translocation	29.8	FLT3 KIT
4	lymphocytic leukemia	29.7	DNTT KMT2A PAX5
5	dendritic cell tumor	29.7	DNTT MPO PTPRC
6	blastic plasmacytoid dendritic cell	29.6	NCAM1 NPM1
7	leukemia, acute monocytic	29.6	KMT2A MPO
8	leukemia, chronic myeloid	29.5	DNTT FLT3 KIT KMT2A MPO
9	acute biphenotypic leukemia	29.5	DNTT KMT2A MPO
10	lymphoblastic lymphoma	29.4	DNTT KMT2A MPO PTPRC
11	lymphoma, hodgkin, classic	29.4	PAX5 PTPRC
12	myeloma, multiple	29.4	KIT NCAM1 PTPRC
13	myelodysplastic syndrome	29.3	ANPEP DNTT FLT3 KIT KMT2A NPM1
14	acute promyelocytic leukemia	29.3	ANPEP FLT3 MPO NCAM1 NPM1 PTPRC
15	leukemia, chronic lymphocytic	29.3	ANPEP DNTT PAX5 PTPRC
16	acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	29.2	DNTT FLT3 KIT KMT2A MPO
17	ewing sarcoma	29.2	DNTT KIT NCAM1 PTPRC
18	leukemia, acute myeloid	29.2	ANPEP DNTT FLT3 KIT KMT2A MPO
19	precursor t-cell acute lymphoblastic leukemia	28.9	ANPEP DNTT FLT3 KMT2A MPO
20	leukemia, acute lymphoblastic	28.9	ANPEP DNTT FLT3 KMT2A PAX5
21	acute leukemia	28.8	ANPEP DNTT FLT3 KIT KMT2A MPO
22	sarcoma	11.0
23	leukemia	10.6
24	spindle cell sarcoma	10.3
25	acute myeloid leukemia with minimal differentiation	10.2	FLT3 MPO
26	acute myeloblastic leukemia without maturation	10.2	FLT3 NPM1
27	lymphoma	10.2
28	chronic monocytic leukemia	10.2	MPO PTPRC
29	primary cutaneous anaplastic large cell lymphoma	10.2	NPM1 PTPRC
30	epidural neoplasm	10.1	DNTT PTPRC
31	photokeratitis	10.1	DNTT PTPRC
32	natural killer cell leukemia	10.1	MPO NCAM1
33	hodgkin's lymphoma, lymphocytic depletion	10.1	PAX5 PTPRC
34	brain sarcoma	10.1
35	tetrasomy 21	10.1	ANPEP DNTT
36	malignant leydig cell tumor	10.1	KIT PAX5
37	anterior scleritis	10.1	MPO NCAM1
38	chronic eosinophilic leukemia	10.1	FLT3 KIT
39	extracutaneous mastocytoma	10.1	KIT PTPRC
40	conventional fibrosarcoma	10.1	KIT PTPRC
41	testicular infarct	10.1	KIT PTPRC
42	8p11 myeloproliferative syndrome	10.1	FLT3 KIT
43	radiculopathy	10.1
44	gastric small cell carcinoma	10.1	NCAM1 PTPRC
45	cutaneous ganglioneuroma	10.1	KIT NCAM1
46	core binding factor acute myeloid leukemia	10.1	FLT3 KIT
47	pediatric lymphoma	10.1	DNTT NCAM1
48	mediastinal cancer	10.0	KIT NCAM1
49	angiomyoma	10.0	KIT NCAM1
50	helsmoortel-van der aa syndrome	10.0	KIT NCAM1

Graphical network of the top 20 diseases related to Myeloid Sarcoma:

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Symptoms & Phenotypes for Myeloid Sarcoma

GenomeRNAi Phenotypes related to Myeloid Sarcoma according to GeneCards Suite gene sharing:

²⁶ (show all 31)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-100	10.06	MPO
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-102	10.06	DNTT FLT3 KIT
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-115	10.06	FLT3
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-120	10.06	FLT3
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-121	10.06	FLT3
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-122	10.06	FLT3
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-123	10.06	DNTT FLT3
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-126	10.06	MPO
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-138	10.06	DNTT
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-151	10.06	DNTT
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-152	10.06	KIT
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-157	10.06	DNTT KIT MPO
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-16	10.06	DNTT
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-163	10.06	FLT3
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-170	10.06	KIT
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-176	10.06	MPO
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-182	10.06	DNTT
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-186	10.06	MPO
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-197	10.06	DNTT
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-25	10.06	FLT3
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-29	10.06	MPO
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-30	10.06	KIT
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-36	10.06	MPO
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-42	10.06	KIT
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-57	10.06	MPO
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-7	10.06	MPO
27	Increased shRNA abundance (Z-score > 2)	GR00366-A-70	10.06	FLT3 MPO
28	Increased shRNA abundance (Z-score > 2)	GR00366-A-73	10.06	DNTT
29	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	10.06	KIT
30	Increased shRNA abundance (Z-score > 2)	GR00366-A-9	10.06	KIT
31	Increased shRNA abundance (Z-score > 2)	GR00366-A-99	10.06	KIT

MGI Mouse Phenotypes related to Myeloid Sarcoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.91	ANPEP DNTT FLT3 KIT KMT2A MPO
2	cellular	MP:0005384	9.87	FLT3 KIT KMT2A NCAM1 NPM1 PAX5
3	cardiovascular system	MP:0005385	9.85	ANPEP DNTT KIT KMT2A MPO NPM1
4	immune system	MP:0005387	9.81	ANPEP DNTT FLT3 KIT KMT2A MPO
5	mortality/aging	MP:0010768	9.56	FLT3 KIT KMT2A MPO NCAM1 NPM1
6	neoplasm	MP:0002006	9.1	FLT3 KIT KMT2A NPM1 PAX5 PTPRC

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Drugs & Therapeutics for Myeloid Sarcoma

Drugs for Myeloid Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 106)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Fludarabine

Approved

Phase 3,Phase 2,Phase 1

75607-67-9, 21679-14-1

30751

Cyclophosphamide

Approved, Investigational

Phase 3,Phase 2

6055-19-2, 50-18-0

2907

Aldesleukin

Approved

Phase 3,Phase 2

85898-30-2, 110942-02-4

leucovorin

Approved

Phase 3

58-05-9

6006 143

Lenograstim

Approved, Investigational

Phase 3,Phase 2,Phase 1

135968-09-1

Etoposide

Approved

Phase 3

33419-42-0

36462

Dexamethasone

Approved, Investigational, Vet_approved

Phase 3

50-02-2

5743

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 3

1177-87-3

Hydrocortisone

Approved, Vet_approved

Phase 3

50-23-7

5754

Daunorubicin

Approved

Phase 3

20830-81-3

30323

Methotrexate

Approved

Phase 3

59-05-2, 1959-05-2

126941

Busulfan

Approved, Investigational

Phase 3

55-98-1

2478

Cytarabine

Approved, Investigational

Phase 3,Phase 2,Phase 1

147-94-4

6253

Thioguanine

Approved

Phase 3

154-42-7

2723601

Idarubicin

Approved

Phase 3,Phase 2

58957-92-9

42890

Hydrocortisone acetate

Approved, Vet_approved

Phase 3

50-03-3

Darbepoetin alfa

Approved, Investigational

Phase 3

11096-26-7, 209810-58-2

Mitoxantrone

Approved, Investigational

Phase 3,Phase 2

65271-80-9

4212

Bortezomib

Approved, Investigational

Phase 3

179324-69-7

387447 93860

Nicotinamide

Approved, Investigational

Phase 3

98-92-0

936

Sorafenib

Approved, Investigational

Phase 3

284461-73-0

216239 406563

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 3

59-30-3

6037

Niacin

Approved, Investigational, Nutraceutical

Phase 3

59-67-6

938

Anti-Infective Agents

Phase 3,Phase 2,Phase 1

Aspartic Acid

Phase 3

Anti-HIV Agents

Phase 3,Phase 2

Vidarabine Phosphate

Phase 3,Phase 1

Antirheumatic Agents

Phase 3,Phase 2

Hydrocortisone-17-butyrate

Phase 3

Antineoplastic Agents, Phytogenic

Phase 3

Alkylating Agents

Phase 3,Phase 2

Analgesics, Non-Narcotic

Phase 3,Phase 2

Dermatologic Agents

Phase 3

N-Methylaspartate

Phase 3

Folic Acid Antagonists

Phase 3

Antiemetics

Phase 3

Immunologic Factors

Phase 3,Phase 2,Phase 1

Gastrointestinal Agents

Phase 3

Hormone Antagonists

Phase 3

Vitamin B Complex

Phase 3

Etoposide phosphate

Phase 3

Vitamin B9

Phase 3

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 3

Analgesics

Phase 3,Phase 2

glucocorticoids

Phase 3

Peripheral Nervous System Agents

Phase 3,Phase 2

Hormones

Phase 3

Autonomic Agents

Phase 3

Anti-Retroviral Agents

Phase 3,Phase 2

Folate

Phase 3

Interventional clinical trials:

(show all 13)

#	Name	Status	NCT ID	Phase	Drugs
1	Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome	Completed	NCT00002798	Phase 3	asparaginase;daunorubicin hydrochloride;fludarabine phosphate;therapeutic hydrocortisone;cytarabine;idarubicin;dexamethasone;thioguanine;etoposide;methotrexate;cyclophosphamide;busulfan
2	Compare Bosutinib To Imatinib In Subjects With Newly Diagnosed Chronic Phase Philadelphia Chromosome Positive CML	Completed	NCT00574873	Phase 3	Bosutinib;imatinib
3	Darbepoetin Alfa in Patients With Anemic Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS)	Completed	NCT01362140	Phase 3	Darbepoetin alfa;Placebo
4	Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia	Active, not recruiting	NCT01371981	Phase 3	Asparaginase;Bortezomib;Cytarabine;Daunorubicin Hydrochloride;Etoposide;Mitoxantrone Hydrochloride;Sorafenib Tosylate
5	CIP-613, Cytarabine, and Mitoxantrone Hydrochloride in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Granulocytic Sarcoma	Recruiting	NCT02484391	Phase 2	6,8-Bis(benzylthio)octanoic Acid;Cytarabine;Mitoxantrone Hydrochloride
6	MG4101 for Refractory or Relapsed AML	Recruiting	NCT03349502	Phase 2	MG4101
7	Provision of TCRγδ T Cells and Memory T Cells Plus Selected Use of Blinatumomab in Naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies Relapsed or Refractory Despite Prior Transplantation	Recruiting	NCT02790515	Phase 2	Anti-thymocyte globulin (rabbit);Blinatumomab;Cyclophosphamide;Fludarabine;G-CSF;Melphalan;Mesna;Rituximab;Tacrolimus;Thiotepa;Sirolimus
8	Dexrazoxane Hydrochloride in Preventing Heart-Related Side Effects of Chemotherapy in Participants With Blood Cancers	Recruiting	NCT03589729	Phase 2	Cladribine;Cytarabine;Dexrazoxane Hydrochloride;Gemtuzumab Ozogamicin;Idarubicin
9	Vosaroxin and Infusional Cytarabine in Treating Patients With Untreated Acute Myeloid Leukemia	Suspended	NCT02658487	Phase 2	Cytarabine;Vosaroxin
10	Repeat Transplantation for Relapsed or Refractory Hematologic Malignancies Following Prior Transplantation	Terminated	NCT02259348	Phase 2	Cyclophosphamide;Fludarabine;Melphalan;Thiotepa;Rituximab
11	Wee1 Kinase Inhibitor AZD1775 and Combination Chemotherapy in Treating Children, Adolescents and Young Adults With Relapsed or Refractory Acute Myeloid Leukemia	Withdrawn	NCT02791919	Phase 1	Cytarabine;Fludarabine Phosphate;WEE1 Inhibitor AZD1775
12	PET-CT in AML for Detection of Extramedullary AML Manifestations	Completed	NCT01278069
13	Central Nervous System (CNS) Involvement in Acute Myeloid Leukemia (AML)	Not yet recruiting	NCT03410407

Search NIH Clinical Center for Myeloid Sarcoma

Cochrane evidence based reviews: sarcoma, myeloid

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Genetic Tests for Myeloid Sarcoma

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Anatomical Context for Myeloid Sarcoma

MalaCards organs/tissues related to Myeloid Sarcoma:

⁴¹

Myeloid, Bone, Breast, Bone Marrow, Skin, Brain, Lymph Node

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Publications for Myeloid Sarcoma

Articles related to Myeloid Sarcoma:

(show top 50) (show all 1127)

#	Title	Authors	Year
1	RTK-RAS pathway mutation is enriched in myeloid sarcoma. ( 29789584 )	Choi M....Koh Y.	2018
2	Coexistent cutaneous myeloid sarcoma in a patient with invasive papillary carcinoma of thyroid - A rare presentation. ( 29855456 )	Tripathy S....Baisakh M.	2018
3	Activity of decitabine in pericardial myeloid sarcoma. ( 29779081 )	Evers D....van der Velden W.J.F.M.	2018
4	A Rare Case of Relapsed Pediatric Acute Promyelocytic Leukemia with Skin Involvement by Myeloid Sarcoma. ( 29650946 )	AraA_jo N.S....de Sousa Rodrigues C.F.	2018
5	A unique clinical presentation of de novo acute promyelocytic leukemia as a myeloid sarcoma of the breast. ( 29931624 )	Oravcova I....Drgona L.	2018
6	Intermediate dose cytarabine in treatment myeloid sarcoma of the bilateral breast after allogeneic stem cell transplantation: A case report and literature review. ( 29893346 )	Aznab M....Khazaie M.	2018
7	Detection of prognostically relevant mutations and translocations in myeloid sarcoma by next generation sequencing. ( 28633614 )	Kashofer K....Zebisch A.	2018
8	Loss of RKIP is a frequent event in myeloid sarcoma and promotes leukemic tissue infiltration. ( 29295844 )	Caraffini V....Zebisch A.	2018
9	Myeloid sarcoma involving the greater wing of the sphenoid bone and additional skeletal sites presenting with unilateral proptosis and fevers. ( 29557698 )	Wang J.C....Freitag S.K.	2018
10	Connecting the Dots: A Case of Myeloid Sarcoma. ( 29729239 )	Rose A....Brayer J.	2018
11	Myeloid Sarcoma Presented as Generalized Lymphadenopathy: Mimicking Malignant Lymphoma. ( 29398826 )	Gajendra S....Sachdev R.	2018
12	Expression of programmed death ligand 1 is associated with poor prognosis in myeloid sarcoma patients. ( 29602174 )	Kawamoto K....Ohshima K.	2018
13	Clinicopathological characteristics of de novo and secondary myeloid sarcoma: A monocentric retrospective study. ( 29532520 )	Claerhout H....Boeckx N.	2018
14	A Rare Cause of Paraplegia: Myeloid Sarcoma. ( 29393854 )	ArslantaA9 E....A9zdemir N.	2018
15	Peritoneal Myeloid Sarcoma in a Patient Treated for a Testicular Seminoma. ( 29955031 )	Longo R....Campitiello M.	2018
16	Clinical characteristics of pediatric patients with myeloid sarcoma without bone marrow involvement in Japan. ( 29971602 )	Taga T....Ishida Y.	2018
17	Primary Myeloid Sarcoma of the Prostate: A Case Report and Literature Review. ( 29854498 )	Nguyen R....Sayar H.	2018
18	Sacral Myeloid Sarcoma Manifesting as Radiculopathy in a Pediatric Patient: An Unusual Form of Myeloid Leukemia Relapse. ( 29888021 )	Rodrigues J.R....Carvalho S.	2018
19	Myeloid sarcoma of the small intestine in a patient without overt acute myeloid leukaemia: a challenging diagnosis of a rare condition. ( 29848520 )	NemAcsio R.A....Leite J.S.	2018
20	Myeloid sarcoma as a simulator of advanced ovarian cancer: A case report. ( 29666016 )		2018
21	Case Report of Myeloid Sarcoma Masquerading as In-Transit Metastasis at a Previous Melanoma Site: Avoiding a Diagnostic Pitfall. ( 29863571 )		2018
22	Myeloid Sarcoma Predicts Superior Outcome in Pediatric AML; Can Cytogenetics Solve the Puzzle? ( 29680411 )		2018
23	Isolated Pancreatic Myeloid Sarcoma Associated with t(8;21)/RUNX1-RUNX1T1 Rearrangement. ( 29151502 )		2018
24	Myeloid Sarcoma after Allogenic Stem Cell Transplantation for Acute Myeloid Leukemia: Successful Consolidation Treatment Approaches in Two Patients. ( 29682375 )		2018
25	Role of Positron Emission Tomography Imaging in Myeloid Sarcoma. ( 29430131 )		2018
26	Myeloid sarcoma with megakaryoblastic differentiation presenting as a breast mass. ( 29684340 )		2018
27	Case report: Purulent transformation of granulocytic sarcoma: An unusual pattern of differentiation in acute promyelocytic leukemia. ( 29465554 )	Collinge E...Paubelle E	2018
28	Successful Treatment of Relapsed Pediatric Acute Myeloid Leukemia Presenting as Central Nervous System Myeloid Sarcoma: A Single-Institution Case Series. ( 30543582 )	Bujold KE...Barbour M	2018
29	A Case of Granulocytic Sarcoma or Extramedullary Acute Myelomonocytic Leukemia of the Gallbladder. ( 30352989 )	Holzwanger EA...Kathman DL	2018
30	Myeloid Sarcoma of the Paranasal Sinuses in a Patient with Acute Myeloid Leukemia. ( 30369515 )	Suzuki J...Katori Y	2018
31	Intraoral granulocytic sarcoma as a manifestation of myelofibrosis: A case report and review of the literature. ( 30188579 )	Nunes LFM...Silva TA	2018
32	Mediastinal Myeloid Sarcoma with TP53 Mutation Preceding Acute Myeloid Leukemia with a PICALM-MLLT10 Fusion Gene. ( 30227397 )	Naesens L...Selleslag D	2018
33	Myeloid sarcoma arising in malignant phyllodes tumour: clonal relationships revealed by comparative genome-wide analyses. ( 28211578 )	Arai H...Oyama T	2018
34	A case of ureteral myeloid sarcoma post-renal transplantation. ( 29486724 )	Ying L...Mou S	2018
35	Myeloid sarcoma without circulating leukemia mimicking gastrointestinal malignancy and lymphoma. ( 30046410 )	Ravulapati S...Lionberger JM	2018
36	Obstructive jaundice caused by myeloid sarcoma in duodenal ampulla. ( 30253977 )	Li X...Li Y	2018
37	Myeloid Sarcoma of Orbits: Effectiveness of a Low-Dose Radiation Regimen. ( 30271643 )	Ravisankar S...Shah M	2018
38	Isolated myeloid sarcoma in the pancreas and orbit: A case report and review of literature. ( 30294614 )	Zhu T...Dong HJ	2018
39	Acute myeloid leukaemia relapse presenting as cardiac myeloid sarcoma. ( 30389743 )	Waselewski A...Miller SR	2018
40	Isolated Orbital Myeloid Sarcoma as a Therapy-related Myeloid Neoplasm. ( 30449814 )	Ishiguro K...Takahashi T	2018
41	Primary Myeloid Sarcoma of the Breast: A Case Report and Review of Literature. ( 30464895 )	Gomaa W...Ghanim A	2018
42	Increased angiogenesis seems to correlate with inferior overall survival in myeloid sarcoma patients. ( 30509052 )	Piccaluga PP...Ascani S	2018
43	A case of myeloid sarcoma presenting with an orbital mass, hearing loss, and multiple cranial neuropathies. ( 30511548 )	Lim SH...Jeon IS	2018
44	A Lateral Neck Myeloid Sarcoma Presenting as Acute Otitis Externa. ( 30551696 )	Mozafari R...Asadollahi-Amin A	2018
45	Primary granulocytic sarcoma presenting as a lumbar plexopathy in a nonleukemic patient. ( 30038120 )	Talish M...Kacchare N	2018
46	Granulocytic sarcoma and mediastinal germ cell tumor: A common cell of origin? ( 29913128 )	Mukherjee S...Cherry M	2018
47	An uncommon granulocytic sarcoma of the breast: a case report and literature review. ( 29983576 )	Zhai J...Fang Y	2018
48	Nonleukemic granulocytic sarcoma of orbit after blunt trauma: A case report and review of literature. ( 29642189 )	Cheng Y...Ma X	2018
49	Radiotherapy for isolated granulocytic sarcoma: Case report and review of literature. ( 29594235 )	Dominguez Rull?n JA...Sancho Garc?a S	2018
50	Fine-needle aspiration cytology of granulocytic sarcoma presenting as a breast lump - Report of a rare case with a comprehensive literature search. ( 29403218 )	Sharma A...Bhattacharyya S	2018

Sources

Genes for Myeloid Sarcoma

Genes related to Myeloid Sarcoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	MPO	Myeloperoxidase	Protein Coding	34.46	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	9038763 15738870 17700206 (more) 11020993 12959763 8902835 17854675 2154905 16579712 17261930 8037168 11419984 17337816 18656695
2	FLT3	Fms Related Tyrosine Kinase 3	Protein Coding	25.35	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	15352981
3	PTPRC	Protein Tyrosine Phosphatase, Receptor Type C	Protein Coding	24.48	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	8037168 17700206 2106752
4	KIT	KIT Proto-Oncogene Receptor Tyrosine Kinase	Protein Coding	22.47	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	11698000
5	ANPEP	Alanyl Aminopeptidase, Membrane	Protein Coding	22.13	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	18794057 11138613
6	NPM1	Nucleophosmin 1	Protein Coding	21.56	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	KMT2A	Lysine Methyltransferase 2A	Protein Coding	20.6	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	11733351 15621793
8	DNTT	DNA Nucleotidylexotransferase	Protein Coding	20.44	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	7572794
9	PAX5	Paired Box 5	Protein Coding	20.06	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	19.44	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	8907283

Sources

Variations for Myeloid Sarcoma

Sources

Expression for Myeloid Sarcoma

Search GEO for disease gene expression data for Myeloid Sarcoma.

Sources

Pathways for Myeloid Sarcoma

Pathways related to Myeloid Sarcoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	NF-kappaB Signaling ⁴	12.28	KIT MPO NCAM1 PAX5 PTPRC
2	Transcriptional misregulation in cancer ³⁷	11.97	FLT3 KMT2A MPO PAX5
3	Tyrosine Kinases / Adaptors ⁴	11.82	FLT3 KIT NPM1
4	Hematopoietic cell lineage ³⁷	11.61	ANPEP DNTT FLT3 KIT
5	Innate Lymphoid Cell Differentiation Pathways ⁶⁵	11.54	KIT NCAM1 PTPRC
6	C-MYB transcription factor network ¹	11.45	ANPEP KIT MPO PAX5
7	Cardiac Progenitor Differentiation ¹	11.33	ANPEP KIT NCAM1
8	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.33	FLT3 KIT NCAM1 PTPRC
9	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.16	ANPEP FLT3 KIT MPO NCAM1 PTPRC
10	B Cell Development Pathways ⁶⁵	10.98	FLT3 KIT PAX5 PTPRC

Sources

GO Terms for Myeloid Sarcoma

Cellular components related to Myeloid Sarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasmic side of plasma membrane	GO:0009898	8.96	KIT PTPRC
2	external side of plasma membrane	GO:0009897	8.92	ANPEP KIT NCAM1 PTPRC

Biological processes related to Myeloid Sarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of apoptotic process	GO:0043066	9.67	FLT3 KIT MPO NPM1
2	positive regulation of ERK1 and ERK2 cascade	GO:0070374	9.63	FLT3 KIT PTPRC
3	viral process	GO:0016032	9.62	ANPEP FLT3 NCAM1 NPM1
4	MAPK cascade	GO:0000165	9.61	FLT3 KIT NCAM1
5	T cell differentiation	GO:0030217	9.48	KIT PTPRC
6	positive regulation of phosphatidylinositol 3-kinase activity	GO:0043552	9.4	FLT3 KIT
7	positive regulation of MAPK cascade	GO:0043410	9.33	FLT3 KIT PTPRC
8	embryonic hemopoiesis	GO:0035162	9.26	KIT KMT2A
9	regulation of B cell receptor signaling pathway	GO:0050855	8.96	PAX5 PTPRC
10	myeloid progenitor cell differentiation	GO:0002318	8.62	FLT3 KIT

Molecular functions related to Myeloid Sarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Ras guanyl-nucleotide exchange factor activity	GO:0005088	9.13	FLT3 KIT NCAM1
2	protein homodimerization activity	GO:0042803	9.02	FLT3 KIT KMT2A NPM1 PTPRC

Sources

Sources for Myeloid Sarcoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia