Myelomeningocele disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MYL020 MIFTS: 53	Myelomeningocele Categories: Rare diseases, Neuronal diseases, Fetal diseases
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Aliases & Classifications for Myelomeningocele

MalaCards integrated aliases for Myelomeningocele:

Name: Myelomeningocele ¹² ⁵³ ⁵⁹ ²⁹ ⁵⁵ ³ ¹⁵

Meningomyelocele ⁵³ ⁴⁴

Characteristics:

Orphanet epidemiological data:

⁵⁹

myelomeningocele
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Infancy,Neonatal;

Classifications:

MalaCards categories:
Global: Rare diseases Fetal diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³³ ³⁴

Congenital malformations, deformations and chromosomal abnormalities

Congenital malformations of the nervous system

Spina bifida

Cervical spina bifida with hydrocephalus

Cervical spina bifida without hydrocephalus

Lumbar spina bifida with hydrocephalus

Lumbar spina bifida without hydrocephalus

Sacral spina bifida with hydrocephalus

Sacral spina bifida without hydrocephalus

Spina bifida, unspecified

Thoracic spina bifida with hydrocephalus

Thoracic spina bifida without hydrocephalus

Unspecified spina bifida with hydrocephalus

Orphanet: ⁵⁹

Rare neurological diseases

Developmental anomalies during embryogenesis

External Ids:

Disease Ontology ¹² DOID:0060326

ICD10 ³³ Q05

MeSH ⁴⁴ D008591

NCIt ⁵⁰ C101201 C98874

SNOMED-CT ⁶⁸ 156890007 203984008 203988006 more

Orphanet ⁵⁹ ORPHA93969

ICD10 via Orphanet ³⁴ Q05.7 Q05.8 Q05.9 more

UMLS via Orphanet ⁷⁴ C0025312

UMLS ⁷³ C0025312 C0086664 C0751316

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Summaries for Myelomeningocele

NIH Rare Diseases : ⁵³ Myelomeningocele is the most severe form of spina bifida. It happens when parts of the spinal cord and nerves come through the open part of the spine. It causes nerve damage and other disabilities. Seventy to ninety percent of children with this condition also have too much fluid on their brains (hydrocephalus). This happens because fluid that protects the brain and spinal cord is unable to drain like it should. The fluid builds up, causing pressure and swelling. Without treatment, a person’s head grows too big, and they may have brain damage. Other disorders of the spinal cord may be seen, including syringomyelia and hip dislocation. The cause of myelomeningocele is unknown. However, low levels of folic acid in a woman's body before and during early pregnancy is thought to play a part in this type of birth defect.

MalaCards based summary : Myelomeningocele, also known as meningomyelocele, is related to neural tube defects, folate-sensitive and strabismus. An important gene associated with Myelomeningocele is MTHFR (Methylenetetrahydrofolate Reductase), and among its related pathways/superpathways are Signaling by Wnt and Wnt / Hedgehog / Notch. The drugs Acetylcholine and Oxybutynin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and skin, and related phenotypes are growth/size/body region and embryo

Disease Ontology : ¹² A spina bifida characterized by protrusion of the spinal cord through an opening, covered by meningeal membranes.

CDC : ³ Spina bifida is a major birth defect of a personâs spine. With good quality medical care people with spina bifida can reach their full potential. If you have spina bifida, or know someone who does, itâs important to get the facts so that you can make the best possible health care choices.

Wikipedia : ⁷⁶ Spina bifida is a birth defect where there is incomplete closing of the backbone and membranes around... more...

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Related Diseases for Myelomeningocele

Diseases related to Myelomeningocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)

#	Related Disease	Score	Top Affiliating Genes
1	neural tube defects, folate-sensitive	32.4	MTHFD1 MTHFR
2	strabismus	29.8	PRICKLE1 VANGL1 VANGL2
3	anencephaly	25.8	CELSR1 DACT1 FOLR1 MTHFD1 MTHFR PRICKLE1
4	neural tube defects	25.7	CBS CELSR1 DACT1 FOLR1 MTHFD1 MTHFR
5	renal agenesis meningomyelocele mullerian defect	11.9
6	chiari malformation type ii	11.4
7	meningocele	11.3
8	chiari malformation	11.2
9	schwartz cohen-addad lambert syndrome	11.0
10	otopalatodigital syndrome, type ii	10.8
11	heterotaxy, visceral, 1, x-linked	10.8
12	chromosome 15q24 deletion syndrome	10.8
13	congenital laryngeal palsy	10.8
14	hydrocephalus	10.3
15	glycine n-methyltransferase deficiency	10.3	CBS MTHFR
16	methotrexate toxicity or dose selection	10.2	MTHFR SLC19A1
17	lens subluxation	10.2	CBS MTHFR
18	neurogenic bladder	10.2
19	cervicitis	10.2
20	pediatric osteosarcoma	10.2	MTHFR SLC19A1
21	scoliosis	10.1
22	placental abruption	10.0	MTHFD1 MTHFR
23	aging	10.0
24	cerebritis	10.0
25	methylmalonic aciduria and homocystinuria, cblc type	10.0	CBS MTHFD1
26	neurogenic bowel	9.9
27	tethered cord syndrome	9.9
28	diastematomyelia	9.9
29	lipomyelomeningocele	9.9
30	cerebral palsy	9.9
31	clubfoot	9.9
32	diaphragmatic hernia, congenital	9.8
33	spinal cord injury	9.8
34	tethered spinal cord syndrome	9.8
35	epilepsy	9.8
36	constipation	9.8
37	syringomyelia	9.8
38	sleep disorder	9.8
39	encephalocele	9.8
40	syringohydromyelia	9.8
41	craniorachischisis	9.8	CELSR1 DACT1 SCRIB VANGL2
42	acute lymphoblastic leukemia, childhood	9.7	MTHFD1 MTHFR SLC19A1
43	clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly	9.7
44	digeorge syndrome	9.7
45	focal dermal hypoplasia	9.7
46	choroiditis	9.7
47	urethritis	9.7
48	teratoma	9.7
49	waardenburg's syndrome	9.7
50	type i	9.7

Graphical network of the top 20 diseases related to Myelomeningocele:

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Symptoms & Phenotypes for Myelomeningocele

MGI Mouse Phenotypes related to Myelomeningocele:

⁴⁶ (show all 16)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	10.29	CELSR1 DACT1 FOLR1 MTHFD1 MTHFR PAX3
2	embryo	MP:0005380	10.26	SCRIB SLC19A1 TBXT VANGL1 VANGL2 CELSR1
3	cardiovascular system	MP:0005385	10.21	DACT1 FOLR1 MTHFD1 PAX3 PRICKLE1 SCRIB
4	mortality/aging	MP:0010768	10.21	PRICKLE1 SCRIB SLC19A1 TBXT VANGL1 VANGL2
5	limbs/digits/tail	MP:0005371	10.16	CELSR1 DACT1 MTHFD1 MTHFR PAX3 PRICKLE1
6	digestive/alimentary	MP:0005381	10.14	DACT1 FOLR1 PAX3 PRICKLE1 SCRIB SLC19A1
7	nervous system	MP:0003631	10.14	CELSR1 DACT1 FOLR1 MTHFD1 MTHFR PAX3
8	craniofacial	MP:0005382	10.09	CELSR1 FOLR1 PAX3 PRICKLE1 SCRIB TBXT
9	hearing/vestibular/ear	MP:0005377	10.04	FOLR1 PAX3 PRICKLE1 SCRIB VANGL1 VANGL2
10	integument	MP:0010771	9.95	CELSR1 MTHFR PAX3 PRICKLE1 SLC19A1 TBXT
11	renal/urinary system	MP:0005367	9.92	DACT1 FOLR1 PAX3 PRICKLE1 SCRIB SLC19A1
12	no phenotypic analysis	MP:0003012	9.91	VANGL2 DACT1 MTHFR PAX3 PRICKLE1 SCRIB
13	reproductive system	MP:0005389	9.86	CELSR1 DACT1 MTHFR SCRIB SLC19A1 TBXT
14	respiratory system	MP:0005388	9.63	VANGL1 VANGL2 CELSR1 PAX3 PRICKLE1 SCRIB
15	skeleton	MP:0005390	9.56	CELSR1 DACT1 MTHFR PAX3 PRICKLE1 TBXT
16	vision/eye	MP:0005391	9.17	CELSR1 FOLR1 MTHFR PAX3 PRICKLE1 SCRIB

Sources

Drugs & Therapeutics for Myelomeningocele

Drugs for Myelomeningocele (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Acetylcholine

Approved

Phase 4

51-84-3

187

Synonyms:

2-(Acetyloxy)-N,N,N-trimethylethanaminium

Acetilcolina cusi

Acetyl choline ion

Acetylcholine bromide

Acetylcholine cation

acetylcholine chloride

Acetylcholine chloride

Acetylcholine Chloride

Acetylcholine fluoride

Acetylcholine hydroxide

Acetylcholine iodide

Acetylcholine L tartrate

Acetylcholine L-tartrate

Acetylcholine perchlorate

Acetylcholine picrate

Acetylcholine picrate (1:1)

Acetylcholine sulfate (1:1)

Acetylcholinium: acetyl-choline

ACh

Alcon brand OF acetylcholine chloride

Azetylcholin

Bournonville brand OF acetylcholine chloride

Bromide, acetylcholine

Bromoacetylcholine

Chloroacetylcholine

Choline acetate

Choline acetate (ester)

Choline acetic acid

Ciba vision brand OF acetylcholine chloride

Cusi, acetilcolina

Fluoride, acetylcholine

Hydroxide, acetylcholine

Iodide, acetylcholine

Iolab brand OF acetylcholine chloride

L-Tartrate, acetylcholine

Miochol

O-Acetylcholine

Perchlorate, acetylcholine

Oxybutynin

Approved, Investigational

Phase 4

5633-20-5

4634

Synonyms:

1508-65-2 (hydrochloride)

4-(diethylamino)-2-Butynyl alpha-phenylcyclohexaneglycolate ester

4-(diethylamino)-2-Butynyl alpha-phenylcyclohexaneglycolic acid ester

4-(Diethylamino)-2-butynyl alpha-phenylcyclohexaneglycolic acid ester

4-(diethylamino)-2-Butynyl a-phenylcyclohexaneglycolate ester

4-(diethylamino)-2-Butynyl a-phenylcyclohexaneglycolic acid ester

4-(diethylamino)-2-Butynyl α-phenylcyclohexaneglycolate ester

4-(diethylamino)-2-Butynyl α-phenylcyclohexaneglycolic acid ester

4-(diethylamino)-2-butynyl-alpha-cyclohexyl-alpha-hydroxybenzeneacetate

4-(diethylamino)-2-Butynyl-alpha-cyclohexyl-alpha-hydroxybenzeneacetate

4-(diethylamino)-2-butynyl-alpha-phenylcyclohexaneglycolate

4-(diethylamino)-2-Butynyl-alpha-phenylcyclohexaneglycolate

4-(diethylamino)but-2-yn-1-yl cyclohexyl(hydroxy)phenylacetate

4-(diethylamino)but-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylacetate

4-diethylamino-2-Butinyl a-cyclohexylmandelat

4-diethylamino-2-Butinyl alpha-cyclohexylmandelat

4-Diethylamino-2-butinyl alpha-cyclohexylmandelat

4-diethylamino-2-Butinyl α-cyclohexylmandelat

4-diethylamino-2-Butynyl alpha-phenylcyclohexaneglycolate

4-Diethylamino-2-butynyl alpha-phenylcyclohexaneglycolate

4-diethylamino-2-Butynyl alpha-phenylcyclohexaneglycolic acid

4-diethylamino-2-Butynyl a-phenylcyclohexaneglycolate

4-diethylamino-2-Butynyl a-phenylcyclohexaneglycolic acid

4-diethylamino-2-Butynyl α-phenylcyclohexaneglycolate

4-diethylamino-2-Butynyl α-phenylcyclohexaneglycolic acid

5633-20-5

AC1L1ILV

AC-2153

apo-Oxybutynin

Benzeneacetate, a-cyclohexyl-a-hydroxy-, 4-(diethylamino)-2-butynyl ester

Benzeneacetate, alpha-cyclohexyl-alpha-hydroxy-, 4-(diethylamino)-2-butynyl ester

Benzeneacetate, α-cyclohexyl-α-hydroxy-, 4-(diethylamino)-2-butynyl ester

Benzeneacetic acid, a-cyclohexyl-a-hydroxy-, 4-(diethylamino)-2-butynyl ester

Benzeneacetic acid, alpha-cyclohexyl-alpha-hydroxy-, 4-(diethylamino)-2-butynyl ester

Benzeneacetic acid, α-cyclohexyl-α-hydroxy-, 4-(diethylamino)-2-butynyl ester

BPBio1_000214

BRD-A65013509-003-03-8

BSPBio_000194

C07360

CCRIS 1923

CHEBI:7856

CHEMBL1231

CID4634

Contimin

Cyclohexaneglycolate, alpha-phenyl-, 4-(diethylamino)-2-butynyl ester

Cyclohexaneglycolate, a-phenyl-, 4-(diethylamino)-2-butynyl ester

Cyclohexaneglycolate, α-phenyl-, 4-(diethylamino)-2-butynyl ester

Cyclohexaneglycolic acid, .alpha.-phenyl-, 4-(diethylamino)-2-butynyl ester

Cyclohexaneglycolic acid, alpha-phenyl-, 4-(diethylamino)-2-butynyl ester

Cyclohexaneglycolic acid, a-phenyl-, 4-(diethylamino)-2-butynyl ester

Cyclohexaneglycolic acid, α-phenyl-, 4-(diethylamino)-2-butynyl ester

Cystonorm

Cystrin

D00465

DB01062

Ditropan

Ditropan, Lyrinel XL, Oxytrol, Oxybutynin

Dresplan

Dridase

Driptane

FT-0082890

Gelnique

Gen-oxybutynin

HSDB 3270

I06-2117

L000923

Lopac0_000923

LS-28714

MolPort-003-849-741

NCGC00015767-06

NCGC00089795-02

novo-Oxybutynin

Nu-oxybutyn

Oxibutinina

Oxibutinina [INN-Spanish]

Oxibutyninum

Oxyb abz

Oxybugamma

Oxybutin holsten

Oxybutinin

Oxybuton

oxybutynin

Oxybutynin

Oxybutynin (USAN/INN)

Oxybutynin [USAN:INN:BAN]

Oxybutynin al

Oxybutynin azu

Oxybutynin base

Oxybutynin Base

Oxybutynin chloride

Oxybutynin heumann

Oxybutynin hexal

Oxybutynin hydrochloride

Oxybutynin stada

oxybutynin topical gel

Oxybutynin topical gel

Oxybutynin von CT

Oxybutynine

Oxybutynine [INN-French]

Oxybutynin-puren

Oxybutynin-ratiopharm

Oxybutyninum

Oxybutyninum [INN-Latin]

Oxymedin

Oxytrol

Oxytrol (TN)

PMS-Oxybutynin

Pollakisu

Prestwick0_000287

Prestwick1_000287

Prestwick2_000287

Prestwick3_000287

Renamel

Ryol

S1754_Selleck

Spasmex oxybutynin

Spasyt

SPBio_002413

Tavor

transdermal patch

Transdermal patch

UNII-K9P6MC7092

Zatur

abobotulinumtoxinA

Phase 4

Botulinum Toxins

Phase 4

Botulinum Toxins, Type A

Phase 4

Cholinergic Agents

Phase 4,Phase 2

Neuromuscular Agents

Phase 4

Neurotransmitter Agents

Phase 4,Phase 2

onabotulinumtoxinA

Phase 4

Peripheral Nervous System Agents

Phase 4

Darifenacin

Approved, Investigational

Phase 2

133099-04-4

444031

Synonyms:

(S)-1-(2-(2,3-dihydro-5-Benzofuranyl)ethyl)-a,a-diphenyl-3-pyrrolidineacetamide

(S)-1-(2-(2,3-dihydro-5-Benzofuranyl)ethyl)-alpha,alpha-diphenyl-3-pyrrolidineacetamide

(S)-1-(2-(2,3-Dihydro-5-benzofuranyl)ethyl)-alpha,alpha-diphenyl-3-pyrrolidineacetamide

(S)-1-(2-(2,3-dihydro-5-Benzofuranyl)ethyl)-α,α-diphenyl-3-pyrrolidineacetamide

133099-04-4

2-[(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenylacetamide

2-{(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl}-2,2-diphenylacetamide

AC1L9FKY

AC-302

CHEBI:391960

CHEMBL1346

CID444031

D03654

darifenacin

Darifenacin

Darifenacin (USAN/INN)

Darifenacin hydrobromide

Darifenacin hydrochloride

Darifenacina

Darifenacine

Darifénacine

Darifenacinum

Darifenicin

DB00496

Emselex

Enablex

LS-187359

MolPort-005-943-011

NCGC00168775-01

STOCK6S-73577

Cholinergic Antagonists

Phase 2

Muscarinic Antagonists

Phase 2

Methenamine

Approved, Vet_approved

Phase 1

100-97-0

4101

Synonyms:

[16]-Adamazane, inn

1,3,5,7-Tetraazaadamantane

1,3,5,7-tetraazatricyclo (3.3.1.1(3,7))Decane

1,3,5,7-tetraazatricyclo(3.3.1.13,7)Decane

1,3,5,7-tetraazatricyclo(3.3.1.13,7)Decane hydroiodide

1,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]Decane

1,3,5,7-tetraazatricyclo[3.3.1.1~3,7~]decane

1,3,5,7-tetraazatricyclo[3.3.1.13,7 ]Decane

1,3,5,7-tetraazatricyclo[3.3.1.13,7]decane

aceto HMT

Aminoform

Aminoformaldehyde

Ammoform

Ammonioformaldehyde

Antihydral

Carin

Cystamin

Cystogen

Duirexol

e239

Ekagom H

Esametilentetramina

Formaldehyde-ammonia 6:4

Formamine

Formin

Formin (heterocycle)

Formin (the heterocyclic compound)

Grasselerator 102

H.m.t.

Herax uts

Heterin

HEX

Hexa

Hexa (vulcanization accelerator)

Hexa-flo-pulver

Hexaform

Hexaloids

Hexamethylamine

Hexamethylenamine

Hexamethylene tetramine

Hexamethyleneamine

Hexamethylenetetraamine

Hexamethylenetetramine

Hexamethylenetetramine (aliphatic)

Hexamethylenetetramine, 8ci

Hexamethylenetetramine, acs

Hexamethylenetetramine-palladium chloride adduct

Hexamethylenetetraminum

Hexamethylentetramin

Hexamethylentetramine

Hexamethylentetraminum

Hexamine

Hexamine (heterocycle)

Hexamine silver

Hexaminum

Hexasan

Hexilmethylenamine

HMT

HMTA

Mandelamine

metenamina

Metenamina

Methamin

Methenamin

Methenamine

méthénamine

Methenamine silver

Methenamine, silver

methenaminum

Methenaminum

Metramine

Naphthamine

Natasol fast orange GR salt

Nocceler H

Preparation af

Resotropin

S 4 (Heterocycle)

Sanceler H

Silver methenamine

Silver, hexamine

Silver, methenamine

Tetraazaadamantane

Uramin

Uratrine

Urisol

Uritone

Urodeine

uro-Phosphate

Urotropin

Urotropine

Vesaloin

Vesalvine

Vulkacit H 30

Vulkacit H30

Xametrin

Methenamine hippurate

Phase 1

Acidophilus

Nutraceutical

Phase 1

Menthol

Approved

Not Applicable

2216-51-5

16666

Synonyms:

(&#8722

(-)-(1R,3R,4S)-Menthol

(-)-menthol

()-Menthol

(-)-Menthyl alcohol

(-)-p-Menthan-3-ol

(-)-trans-p-Menthan-cis-ol

(-)-trans-P-Menthan-cis-ol

(+-)-(1R*,3R*,4S*)-Menthol

(+-)-Menthol

(+)-Neo-menthol

(+)-p-Menthan-3-ol

(+/-)-Menthol

(+/-)-p-Menthan-3-ol

(1a,2b,5a)-5-Methyl-2(1-methylethyl)cyclohexanol

(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol

(1R-(1-a,2-b,5-a))-5-Methyl-2-(1-methylethyl)cyclohexanol

(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol

(1R-(1-α,2-β,5-α))-5-methyl-2-(1-methylethyl)cyclohexanol

(1R)-(-)-Menthol

(1r,2s,5r)-(-)-menthol

(1R,2S,5R)-(-)-Menthol

(1R,2S,5R)-Menthol

(1R,3R,4S)-(-)-Menthol

(1R,3R,4S)-(-)-MENTHOL

(1S, 2S, 5R)-(+)-Neomenthol

(1S,2R,5R)-(+)-Isomenthol

(1S,2R,5S)-(+)-Menthol

(1S,2R,5S)-Menthol

(1α,2β,5α)-5-methyl-2(1-methylethyl)cyclohexanol

(L)-MENTHOL

(r)-(-)-menthol

(R)-(-)-Menthol

)-Menthol

1490-04-6

15356-60-2

15356-70-4

15785_RIEDEL

15785_SIAL

19863P

1-Menthol

20747-49-3

2216-51-5

2-Isopropyl-5-methylcyclohexanol

3-p-Menthol

491-02-1

4-Isopropyl-1-methylcyclohexan-3-ol

551376_ALDRICH

551376_FLUKA

588733_ALDRICH

5-Methyl-2-(1-methylethyl)cyclohexanol

5-Methyl-2-(1-methylethyl)-cyclohexanol

5-methyl-2-(propan-2-yl)cyclohexanol

5-methyl-2-propan-2-ylcyclohexan-1-ol

5-Methyl-2-propan-2-ylcyclohexan-1-ol

613290_ALDRICH

613290_FLUKA

63660_FLUKA

63670_ALDRICH

63670_FLUKA

63975-60-0

6C6A4A8C-A054-468C-A1F0-F29E39838CF2

89-78-1

98167-53-4

AC1L1B2E

AC1L28FR

AC1Q1NQ2

AC1Q2QQM

AI3-08161

AI3-52408

AKOS000119740

AR-1J3337

BB_NC-0057

BRN 1902288

BRN 3194263

BSPBio_003062

C00400

C10H20O

Caswell No. 540

CCRIS 3728

CCRIS 375

CCRIS 4666

CCRIS 9231

CHEBI:15409

CHEBI:545611

CHEMBL256087

CHEMBL470670

CID1254

CID16666

cis-1 ,3-trans-1,4-(+-)-menthol

cis-1,3-trans-1,4-(+-)-menthol

D-(-)-Menthol

d,l-Menthol

D00064

D008610

D04849

D04918

DB00825

DivK1c_000820

dl-3-p-Menthanol

dl-Menthol

dl-Menthol (JP15)

d-Menthol

d-Neomenthol

D-p-Menthan-3-ol

EINECS 201-939-0

EINECS 207-724-8

EINECS 216-074-4

EINECS 218-690-9

EINECS 239-387-8

EINECS 239-388-3

EPA Pesticide Chemical Code 051601

FEMA No. 2665

Fisherman's friend lozenges

Fisherman's friend lozenges (TN)

Headache crystals

Hexahydrothymol

HMS1922G13

HMS2092L14

HMS502I22

HSDB 5662

HSDB 593

I06-1216

I14-7371

IDI1_000820

KBio1_000820

KBio2_000785

KBio2_003353

KBio2_005921

KBio3_002562

KBioSS_000785

Kerasal

l-(-)-Menthol

L-(-)-menthol

L-(-)-Menthol

Levomenthol

Levomenthol [INN:BAN]

Levomentholum

Levomentholum [INN-Latin]

Levomentol

l-Menthol

L-menthol

L-Menthol

l-Menthol (JP15)

l-Menthol (natural)

l-Menthol (TN)

LMPR0102090001

LS-2353

LS-57201

LS-886

LS-89531

LS-89533

M0321

M0545

M2772_SIAL

Menthacamphor

MENTHOL

--MENTHOL

Menthol (USP)

Menthol (VAN)

Menthol natural

Menthol natural, brazilian

Menthol racemic

Menthol racemique

Menthol racemique [French]

Menthol solution

Menthol, (1alpha,2beta,5alpha)-isomer

Menthol, (1alpha,2beta,5alpha)-Isomer

Menthomenthol

Menthyl alcohol

MLS002207256

MolPort-000-849-729

MolPort-001-793-392

NCGC00159382-02

NCGC00159382-03

NCGC00164247-01

NCGC00164247-02

nchembio862-comp1

NCI-C50000

Neoisomenthol

NINDS_000820

NOOLISFMXDJSKH-KXUCPTDWBX

NSC 2603

NSC 62788

NSC2603

NSC62788

Peppermint camphor

p-Menthan-3-ol

P-Menthan-3-ol

Racementhol

Racementhol [INN:BAN]

Racementholum

Racementholum [INN-Latin]

Racementol

Racementol [INN-Spanish]

Racemic menthol

RACEMIC MENTHOL U.S.P.

rac-Menthol

Robitussin Cough Drops

SDCCGMLS-0066659.P001

SMR001306785

SPBio_000869

Spectrum_000305

SPECTRUM1503134

Spectrum2_000855

Spectrum3_001561

Spectrum5_001060

STK802468

Tra-kill tracheal mite killer

U.S.p. menthol

U.S.P. Menthol

UNII-BZ1R15MTK7

UNII-L7T10EIP3A

UNII-YS08XHA860

W266507_ALDRICH

W266523_ALDRICH

W266590_ALDRICH

WLN: L6TJ AY1&1 BQ D1

WLN: L6TJ AY1&1 DQ D1 -L

ZINC01482164

Nitrous oxide

Approved, Vet_approved

10024-97-2

948

Synonyms:

00583_FLUKA

10024-97-2

126386-65-0

129451-49-6

130835-71-1

147527-07-9

175876-44-5

295590_ALDRICH

794457-85-5

847968-13-2

850203-00-8

AC1L1ADZ

C00887

CCRIS 1225

CHEBI:17045

CHEMBL1234579

CID948

D00102

D009609

Diazyne 1-oxide

Dinitrogen monoxide

Dinitrogen oxide

Distickstoffmonoxid

e942

EINECS 233-032-0

Factitious air

FEMA 2779

FEMA No. 2779

Gas, laughing

Gas, Laughing

gaz hilarant

Gaz hilarant

HSDB 504

Hyponitrous acid anhydride

Lachgas

Laughing gas

LS-7622

N2O

Nitral

Nitrious oxide

Nitrogen hypoxide

Nitrogen monoxide

Nitrogen oxide (N2O)

Nitrogen protoxide

nitrogenium oxydulatum

Nitrogenium oxydulatum

nitrous oxide

Nitrous oxide (JP15/usp)

Nitrous oxide (JP15/USP)

Nitrous oxide (TN)

Nitrous oxide [Anaesthetics, volatile]

Nitrous oxide [JAN]

Nitrous oxide [UN1070] [Nonflammable gas]

Nitrous oxide, compressed

Nitrous oxide, jan, usan

Nitrous oxide, refrigerated liquid

Nitrous oxide, refrigerated liquid [UN2201] [Nonflammable gas]

Nitrous-oxide

NITROUS-OXIDE

NNO

Oxide, nitrous

Oxide, Nitrous

oxido Nitroso

Oxido nitroso

Oxido nitroso [Spanish]

oxidodinitrogen(N--N)

Oxidodinitrogen(N--N)

oxyde nitreux

Oxyde nitreux

protoxyde d'azote

Protoxyde d'azote

Protoxyde d'azote [French]

R-744a

Stickdioxyd

Stickdioxyd [German]

Stickstoff(I)-oxid

UN1070

UN2201

Cola

Nutraceutical

Not Applicable

Interventional clinical trials:

(show all 29)

#	Name	Status	NCT ID	Phase	Drugs
1	Effect of Botulinum Toxin in Neurogenic Bladders in Children With Myelomeningocele	Unknown status	NCT00175123	Phase 4	Botulinum A toxin
2	2 Week Open-label Pharmacodynamic and Pharmacokinetic Study of Multiple Doses of a Darifenacin Liquid Oral Suspension in Children (2 - 15 Yrs) With Neurogenic Detrusor Overactivity	Terminated	NCT00712322	Phase 2	Darifenacin;Darifenacin;Darifenacin;Darifenacin
3	Bacteriuria Eradication Through Probiotics	Unknown status	NCT00717600	Phase 1
4	Fetoscopic Meningomyelocele Repair Study	Recruiting	NCT02230072	Phase 1
5	Reciprocating Gait Orthoses for Paraplegia Patients	Unknown status	NCT02227407	Not Applicable
6	Self-esteem and Neuro-urological Follow-up in Patients With Spina Bifida or Spinal Cord Injury	Unknown status	NCT01606618
7	Fetal Myelomeningocele	Completed	NCT03073382
8	Management of Myelomeningocele Study (MOMS)	Completed	NCT00060606	Not Applicable
9	Can Dynamic Ultrasonography Replace Urodynamics in Follow-up of Patients With Myelomeningocele	Completed	NCT03550898	Not Applicable
10	Evaluation of Hysterotomy Site After Open Fetal Surgery	Completed	NCT02493062	Not Applicable
11	Brain Function and White Matter Changes in Congenital, Acute and Chronic Spinal Cord Lesions	Completed	NCT01208584
12	Reliability of the Melbourne Assessment	Completed	NCT02595411
13	Feasibility of the Portable YouGrabber System	Completed	NCT02368223	Not Applicable
14	Safety of a Powder-free Latex Allergy Protocol in the Operating Theatre: A Prospective, Observational Cohort Study	Completed	NCT02575053
15	Prenatal Surgical Repair of Fetal Myelomeningocele	Recruiting	NCT01983345	Not Applicable
16	Extended Criteria For Fetal Myelomeningocele Repair	Recruiting	NCT02664207	Not Applicable
17	Open Myelomeningocele Repair With High Maternal BMI	Recruiting	NCT03044821	Not Applicable
18	Prenatal Endoscopic Repair of Fetal Spina Bifida	Recruiting	NCT02390895	Not Applicable
19	Open Spina Bifida Fetoscopic Repair Project	Recruiting	NCT03562286	Not Applicable
20	Fetoscopic Repair of Isolated Fetal Spina Bifida	Recruiting	NCT03090633	Not Applicable
21	Prospective Cohort of Transitional Urology Patients	Recruiting	NCT03061084
22	Fetal Endoscopic Surgery for Spina Bifida	Recruiting	NCT03315637	Not Applicable
23	Retrograde Colonic Irrigation to Manage Spina Bifida Functional Digestive Sequelae: a Multicenter, Prospective, Randomized Controlled Trial	Recruiting	NCT02361450	Not Applicable
24	Extramembranous and Interosseous Technique of Tibialis Posterior Tendon Transfer	Active, not recruiting	NCT01751503	Not Applicable
25	An Audit of the Posterior Fossa Characterization in Open Spina Bifida Based on Tertiary Center Experience	Active, not recruiting	NCT03544970
26	Cuff Pressure in Infants	Not yet recruiting	NCT03088761
27	Incontinence and Quality of Life in Children With Spina Bifida	Not yet recruiting	NCT03410667	Not Applicable
28	Telemedicine in Spina Bifida Transition: A Pilot Study	Not yet recruiting	NCT03466996	Not Applicable
29	Fetal Myelomeningocele Repair With Maternal BMI Between 35.0 and 40.0	Terminated	NCT02509377	Not Applicable

Search NIH Clinical Center for Myelomeningocele

Cochrane evidence based reviews: meningomyelocele

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Genetic Tests for Myelomeningocele

Genetic tests related to Myelomeningocele:

#	Genetic test	Affiliating Genes
1	Myelomeningocele ²⁹

Sources

Anatomical Context for Myelomeningocele

MalaCards organs/tissues related to Myelomeningocele:

⁴¹

Spinal Cord, Brain, Skin, Bone, Colon, Testes, Heart

Sources

Publications for Myelomeningocele

Articles related to Myelomeningocele:

(show top 50) (show all 721)

#	Title	Authors	Year
1	Analysis of Denver Neurodevelopmental Screening Test Results of Myelomeningocele, Hydrocephalus, and Microcephaly Patients. ( 29899768 )	Alatas I....Canaz H.	2018
2	Strategies and dental care in the treatment of patients with myelomeningocele. ( 29512828 )	Bignardi L....de Queiroz A.M.	2018
3	Early Administration of Magnesium Sulfate during Open Fetal Myelomeningocele Repair Reduces the Dose of Inhalational Anesthesia. ( 29672287 )	Donepudi R....Jain R.	2018
4	Myelomeningocele with Unilateral Right Renal Agenesis: A Case Report. ( 29321944 )	Maeda H....Hosoya M.	2018
5	Comparison of Dorsal Intercostal Artery Perforator Propeller Flaps and Bilateral Rotation Flaps in Reconstruction of Myelomeningocele Defects. ( 29694666 )	Tenekeci G....Tasdelen B.	2018
6	Prenatal superior to postnatal myelomeningocele surgery. ( 29936963 )	Lapa D.A.	2018
7	Surgical Management of Myelomeningocele-Related Spinal Deformities. ( 29355795 )	Ryabykh S.O....Gubin A.V.	2018
8	Fetal modified left myocardial performance index monitoring during open surgery for myelomeningocele repair. ( 29943857 )	Santana E.F.M....Cavalheiro S.	2018
9	Complications, Results, and Risk Factors of Spinal Fusion in Patients With Myelomeningocele. ( 29886920 )	Ollesch B....Georgopoulos G.	2018
10	Intellectual efficiency in children and adolescents with spina bifida myelomeningocele and shunted hydrocephalus. ( 29451990 )	Burro F....Pezzuti L.	2018
11	Latex sensitization in patients with myelomeningocele: contribution of microarray technique. ( 29479928 )	de SA! A.B....SolAc D.	2018
12	The Management of Myelomeningocele Study: full cohort 30-month pediatric outcomes. ( 29246577 )	Farmer D.L....Adzick N.S.	2018
13	Transpsoas cystolitholapaxy in a pediatric patient with myelomeningocele, augmented neobladder, and Mitrofanoff appendicovesicostomy. ( 29904501 )	Lewis S....Srinivasa R.N.	2018
14	Energy Efficiency in Children With Myelomeningocele During Acute Use of Assistive Devices: A Pilot Study. ( 29313712 )	Sansom J.K....Ulrich B.D.	2018
15	Surgical treatment of patients with myelomeningocele-related spine deformities: study of 26 cases. ( 29372371 )	Canaz H....Ucar B.Y.	2018
16	The Use of External Ventricular Drainage to Reduce the Frequency of Wound Complications in Myelomeningocele Closure. ( 29316543 )	McDowell M.M....Greene S.	2018
17	Fetal blood gas values during fetoscopic myelomeningocele repair performed under carbon dioxide insufflation. ( 29750436 )	Baschat A.A....Miller J.L.	2018
18	Body composition and energy expenditure in a population of children and adolescents with myelomeningocele. ( 29333813 )	Caminiti C....Campmany L.	2018
19	Cerebellar herniation demonstrated by the occipitum-dens line: Ultrasonography assessment of normal fetuses, fetuses with myelomeningocele, and fetuses that underwent antenatal myelomeningocele surgery. ( 29427561 )	Barreto E.Q.S....Moron A.F.	2018
20	Predictors of mortality in children with myelomeningocele and symptomatic Chiari type II malformation. ( 29570035 )	McDowell M.M....Greene S.	2018
21	Coincident myelomeningocele and gastroschisis: report of 2 cases. ( 29521606 )	Hauptman J.S....Greene S.	2018
22	Myelomeningocele closure by unilateral lumbar artery perforator flap: Experience with thirty-eight patients. ( 29953654 )	Ucak M.	2018
23	Homologous cryopreserved amniotic membrane in the repair of myelomeningocele: preliminary experience. ( 29858946 )	Marton E....Longatti P.	2018
24	Experience in shunt management on revision free survival in infants with myelomeningocele. ( 29582171 )	Al-Hakim S....Thomale U.W.	2018
25	The Use of a Wheelchair Propulsion Field Test to Determine Peak Heart Rate in Children and Adolescents With Myelomeningocele. ( 29485935 )	Leonardi-Figueiredo M.M....Mattiello-Sverzut A.C.	2018
26	Using poly(l-lactic acid) and poly(E9-caprolactone) blends to fabricate self-expanding, watertight and biodegradable surgical patches for potential fetoscopic myelomeningocele repair. ( 29770571 )	Tatu R....Lin C.Y.	2018
27	Perinatal outcomes after open fetal surgery for myelomeningocele repair: a retrospective cohort study. ( 29878531 )	Moron A.F....Cavalheiro S.	2018
28	Duplex Ultrasonography-Assisted Freestyle Pedicled Perforator Flaps for the Repair of Myelomeningocele Defects. ( 29319575 )	Imaizumi A.	2018
29	Adipofascial Flaps With Acellular Dermal Matrix Compared With Myocutaneous Flap Reconstruction in Lumbar Myelomeningocele Defects. ( 29750727 )	Pourtaheri N....Kumar A.R.	2018
30	Advanced skeletal maturity in children and adolescents with myelomeningocele. ( 29125519 )	Roiz R....Wren T.A.L.	2017
31	Ultrasound based three-dimensional medical model printing for multispecialty team surgical rehearsal prior to fetoscopic myelomeningocele repair. ( 28850758 )	Miller J.L....Baschat A.A.	2017
32	Amniotic Fluid Concentrations of Glial Fibrillary Acidic Protein Do Not Correlate with Prenatal Metrics in Fetuses with Myelomeningocele. ( 28768252 )	Kim A.G....Flake A.W.	2017
33	Complete Reversibility of the Chiari TYPE II Malformation Following Post Natal Repair of Myelomeningocele. ( 28867320 )	Beuriat P.A....Mottolese C.	2017
34	Functional Independence of Children With Myelomeningocele: Is It Associated With the Informal Caregivers' Burden? ( 28888508 )	Cavalari K.N....de Avila M.A.G.	2017
35	Evaluation and Lifetime Management of the Urinary Tract in Patients with Myelomeningocele. ( 28716320 )	Cardona-Grau D....Chiang G.	2017
36	Fetal surgery for myelomeningocele: current clinical practice and translational research. ( 27830929 )	Kabagambe S.K....Farmer D.L.	2017
37	Committee Opinion No. 720: Maternal-Fetal Surgery for Myelomeningocele. ( 28832491 )		2017
38	Early postnatal bladder function in fetoscopic myelomeningocele repair patients. ( 29125525 )	Huang G.O....Tu D.D.	2017
39	Effect of Orthotic Gait Training with Isocentric Reciprocating Gait Orthosis on Walking in Children with Myelomeningocele. ( 29339891 )	Arazpour M....Samadian M.	2017
40	A Case of Fatal Pulmonary Hypoplasia with Congenital Diaphragmatic Hernia, Thoracic Myelomeningocele, and Thoracic Dysplasia. ( 29302380 )	Ito A....Ito Y.	2017
41	Spinal column shortening for tethered cord syndrome associated with myelomeningocele, lumbosacral lipoma, and lipomyelomeningocele in children and young adults. ( 28362188 )	Aldave G....Jea A.	2017
42	Lipomyelomeningocele for the urologist: Should we view it the same as myelomeningocele? ( 28583853 )	Yerkes E.B....Cheng E.Y.	2017
43	The relationship between motor function, cognition, independence and quality of life in myelomeningocele patients. ( 28813080 )	Luz C.L....Hasue R.H.	2017
44	Prenatal folic acid use associated with decreased risk of myelomeningocele: A case-control study offers further support for folic acid fortification in Bangladesh. ( 29190654 )	Kancherla V....Mazumdar M.	2017
45	Committee Opinion No. 720 Summary: Maternal-Fetal Surgery for Myelomeningocele. ( 28832482 )		2017
46	MANAGEMENT OF MYELOMENINGOCELE IN THE PROVINCE OF KWAZULU-NATAL, SOUTH AFRICA. ( 28876688 )	Mnguni M.N....Madiba T.E.	2017
47	Fetal Surgery for Myelomeningocele: A Systematic Review and Meta-Analysis of Outcomes in Fetoscopic versus Open Repair. ( 28910784 )	Kabagambe S.K....Farmer D.L.	2017
48	Tibial derotational osteotomies in two neuromuscular populations: comparing cerebral palsy with myelomeningocele. ( 28904628 )	Thompson R.M....Swaroop V.	2017
49	DiGeorge Syndrome with Sacral Myelomeningocele and Epilepsy. ( 29675073 )	Alkan G....Kartal A.	2017
50	Ultrasound functional evaluation of fetuses with myelomeningocele: study of the interpretation of results. ( 27997256 )	Maroto A....Carreras E.	2017

Sources

Genes for Myelomeningocele

Genes related to Myelomeningocele (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	MTHFR	Methylenetetrahydrofolate Reductase	Protein Coding	36.69	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Publications (show sections)	16602021 11048629 17035141 (more) 10517251 14726815 16602006
2	PAX3	Paired Box 3	Protein Coding	25.91	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	9482647
3	CBS	Cystathionine-Beta-Synthase	Protein Coding	23.26	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	17035141 10517251
4	CELSR1	Cadherin EGF LAG Seven-Pass G-Type Receptor 1	Protein Coding	22.12	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
5	SLC19A1	Solute Carrier Family 19 Member 1	Protein Coding	22.08	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	PRICKLE1	Prickle Planar Cell Polarity Protein 1	Protein Coding	21.94	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
7	TBXT	T-Box Transcription Factor T	Protein Coding	21.94	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
8	FOLR3	Folate Receptor 3	Protein Coding	21.88	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	SCRIB	Scribbled Planar Cell Polarity Protein	Protein Coding	21.87	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
10	FOLR1	Folate Receptor 1	Protein Coding	21.84	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	DACT1	Dishevelled Binding Antagonist Of Beta Catenin 1	Protein Coding	21.74	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
12	VANGL1	VANGL Planar Cell Polarity Protein 1	Protein Coding	21.6	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
13	VANGL2	VANGL Planar Cell Polarity Protein 2	Protein Coding	21.34	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
14	MTHFD1	Methylenetetrahydrofolate Dehydrogenase, Cyclohydrolase And Formyltetrahydrofolate Synthetase 1	Protein Coding	21.2	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)

Sources

Variations for Myelomeningocele

Sources

Expression for Myelomeningocele

Search GEO for disease gene expression data for Myelomeningocele.

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Pathways for Myelomeningocele

Pathways related to Myelomeningocele according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Signaling by Wnt ⁶⁶ Show member pathways TCF dependent signaling in response to WNT ⁶⁶	12.47	DACT1 PRICKLE1 SCRIB VANGL2
2	Wnt / Hedgehog / Notch ⁴	11.8	PAX3 SCRIB VANGL1
3	One carbon pool by folate ³⁷ Show member pathways Antimetabolite Pathway - Folate Cycle, Pharmacodynamics ⁶¹ dTMP de novo biosynthesis (mitochondrial) ¹ folate transformations I ¹ Methionine metabolism ²² methionine salvage ¹ Methotrexate Pathway (Cancer Cell), Pharmacodynamics ⁶¹ One Carbon Metabolism ¹ tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate ¹ Trans-sulfuration and one carbon metabolism ¹	11.65	CBS MTHFD1 MTHFR
4	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	11.43	CBS FOLR1 FOLR3 MTHFD1 MTHFR SLC19A1
5	Antifolate resistance ³⁷	10.75	FOLR1 FOLR3 MTHFR SLC19A1
6	Methotrexate Pathway, Pharmacokinetics ⁶¹ Show member pathways Methotrexate Pathway (Brain Cell), Pharmacokinetics ⁶¹	10.56	FOLR1 SLC19A1
7	Folate-Alcohol and Cancer Pathway ¹ Show member pathways One carbon donor ¹	10.11	CBS MTHFR

Sources

GO Terms for Myelomeningocele

Cellular components related to Myelomeningocele according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	anchored component of external side of plasma membrane	GO:0031362	8.96	FOLR1 FOLR3
2	basolateral plasma membrane	GO:0016323	8.92	FOLR1 SCRIB SLC19A1 VANGL2

Biological processes related to Myelomeningocele according to GeneCards Suite gene sharing:

(show all 24)

#	Name	GO ID	Score	Top Affiliating Genes
1	multicellular organism development	GO:0007275	9.98	CELSR1 DACT1 PAX3 SCRIB TBXT VANGL1
2	anterior/posterior pattern specification	GO:0009952	9.74	CELSR1 TBXT VANGL2
3	wound healing	GO:0042060	9.72	CELSR1 SCRIB VANGL2
4	hair follicle development	GO:0001942	9.62	CELSR1 VANGL2
5	regulation of canonical Wnt signaling pathway	GO:0060828	9.61	DACT1 FOLR1
6	one-carbon metabolic process	GO:0006730	9.61	MTHFD1 MTHFR
7	regulation of Wnt signaling pathway	GO:0030111	9.6	DACT1 VANGL2
8	establishment or maintenance of epithelial cell apical/basal polarity	GO:0045197	9.59	SCRIB VANGL2
9	post-anal tail morphogenesis	GO:0036342	9.58	TBXT VANGL2
10	establishment of planar polarity	GO:0001736	9.58	CELSR1 VANGL2
11	planar cell polarity pathway involved in neural tube closure	GO:0090179	9.56	CELSR1 VANGL2
12	Wnt signaling pathway, planar cell polarity pathway	GO:0060071	9.56	CELSR1 PRICKLE1 VANGL1 VANGL2
13	tetrahydrofolate interconversion	GO:0035999	9.54	MTHFD1 MTHFR
14	apical protein localization	GO:0045176	9.52	CELSR1 VANGL2
15	homocysteine metabolic process	GO:0050667	9.51	CBS MTHFR
16	methionine metabolic process	GO:0006555	9.49	MTHFD1 MTHFR
17	establishment of body hair planar orientation	GO:0048105	9.48	CELSR1 VANGL2
18	transsulfuration	GO:0019346	9.46	CBS MTHFD1
19	lateral sprouting involved in lung morphogenesis	GO:0060490	9.4	CELSR1 VANGL2
20	orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis	GO:0060488	9.37	CELSR1 VANGL2
21	folic acid transport	GO:0015884	9.33	FOLR1 FOLR3 SLC19A1
22	planar dichotomous subdivision of terminal units involved in lung branching morphogenesis	GO:0060489	9.32	CELSR1 VANGL2
23	folic acid metabolic process	GO:0046655	9.26	FOLR1 MTHFD1 MTHFR SLC19A1
24	neural tube closure	GO:0001843	9.1	CELSR1 MTHFD1 PRICKLE1 SCRIB TBXT VANGL2

Molecular functions related to Myelomeningocele according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	folic acid transmembrane transporter activity	GO:0008517	9.16	FOLR1 SLC19A1
2	modified amino acid binding	GO:0072341	8.96	CBS MTHFR
3	folic acid binding	GO:0005542	8.8	FOLR1 FOLR3 SLC19A1

Sources

Sources for Myelomeningocele

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

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¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

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⁴⁴ MeSH

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⁴⁶ MGI

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⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia