MCID: MYL057
MIFTS: 42

Myelopathy, Htlv-1-Associated

Categories: Neuronal diseases, Infectious diseases, Rare diseases, Immune diseases, Genetic diseases

Aliases & Classifications for Myelopathy, Htlv-1-Associated

MalaCards integrated aliases for Myelopathy, Htlv-1-Associated:

Name: Myelopathy, Htlv-1-Associated 57 55
Tropical Spastic Paraparesis 59 73
Human T-Lymphotropic Virus Type I-Associated Myelopathy/tropical Spastic Paraparesis 59
Human T-Lymphotropic Virus Type-1-Associated Myelopathy/tropical Spastic Paraparesis 59
Htlv-1-Associated Myelopathy/tropical Spastic Paraparesis 59
Familial Spastic Paraparesis, Htlv-1-Associated 57
Htlv-1 Associated Myelopathy 54
Htlv1-Associated Myelopathy 37
Ham/tsp 59
Ham 57
Tsp 59

Characteristics:

Orphanet epidemiological data:

59
tropical spastic paraparesis
Inheritance: Not applicable; Age of onset: Adult;

OMIM:

57
Inheritance:
possible genetic factors


Classifications:



External Ids:

OMIM 57 159580
Orphanet 59 ORPHA289326
UMLS via Orphanet 74 C0030481
ICD10 via Orphanet 34 G04.1
MedGen 42 C0030481
KEGG 37 H01724
SNOMED-CT via HPO 69 48522003 312444006 14648003

Summaries for Myelopathy, Htlv-1-Associated

NINDS : 54 For several decades the term “tropical spastic paraparesis” (TSP) has been used to describe a chronic and progressive disease of the nervous system that affects adults living in equatorial areas of the world and causes progressive weakness, stiff muscles, muscle spasms, sensory disturbance, and sphincter dysfunction. The cause of TSP was obscure until the mid-1980s, when an important association was established between the human retrovirus — human T-cell lymphotrophic virus type 1 (also known as HTLV-1) — and TSP. TSP is now called HTLV-1 associated myelopathy/ tropical spastic paraparesis or HAM/TSP. The HTLV-1 retrovirus is thought to cause at least 80 percent of the cases of HAM/TSP by impairing the immune system. In addition to neurological symptoms of weakness and muscle stiffness or spasms, in rare cases individuals with HAM/TSP also exhibit uveitis (inflammation of the uveal tract of the eye), arthritis (inflammation of one or more joints), pulmonary lymphocytic alveolitis (inflammation of the lung), polymyositis (an inflammatory muscle disease), keratoconjunctivitis sicca (persistent dryness of the cornea and conjunctiva), and infectious dermatitis (inflammation of the skin). The other serious complication of HTLV-1 infection is the development of adult T-cell leukemia or lymphoma. Nervous system and blood-related complications occur only in a very small proportion of infected individuals, while most remain largely without symptoms throughout their lives. The HTLV-1 virus is transmitted person-to-person via infected cells: breast-feeding by mothers who are seropositive (in other words, have high levels of virus antibodies in their blood), sharing infected needles during intravenous drug use, or having sexual relations with a seropositive partner. Less than 2 percent of HTLV-1 seropositive carriers will become HAM/TSP patients.

MalaCards based summary : Myelopathy, Htlv-1-Associated, also known as tropical spastic paraparesis, is related to htlv-1 associated myelopathy/tropical spastic paraparesis and tropical spastic paraparesis. An important gene associated with Myelopathy, Htlv-1-Associated is CNTN2 (Contactin 2), and among its related pathways/superpathways is HTLV-I infection. The drugs Lamivudine and Zidovudine have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and eye, and related phenotypes are myelopathy and spastic paraparesis

Description from OMIM: 159580

Related Diseases for Myelopathy, Htlv-1-Associated

Diseases related to Myelopathy, Htlv-1-Associated via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 htlv-1 associated myelopathy/tropical spastic paraparesis 11.8
2 tropical spastic paraparesis 11.7
3 retrovirus-associated myelopathy 11.3
4 human t-cell leukemia virus type 1 11.2
5 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 10.9
6 spastic paraparesis 10.6
7 spasticity 10.6
8 leukemia 10.1
9 type i 10.1
10 t-cell leukemia 10.1
11 adult t-cell leukemia 9.9
12 paroxysmal nocturnal hemoglobinuria 9.9
13 hemoglobinuria 9.9
14 amyotrophic lateral sclerosis 1 9.8
15 aging 9.8
16 pseudopseudohypoparathyroidism 9.8
17 myelodysplastic syndrome 9.8
18 lymphoma 9.8
19 lateral sclerosis 9.8
20 mite infestation 9.8
21 multiple sclerosis 9.6
22 osteoporosis 9.6
23 pernicious anemia 9.6
24 hemolytic uremic syndrome, atypical 1 9.6
25 properdin deficiency, x-linked 9.6
26 leukemia, acute myeloid 9.6
27 anxiety 9.6
28 human immunodeficiency virus type 1 9.6
29 okt4 epitope deficiency 9.6
30 neuromyelitis optica 9.6
31 neutropenia 9.6
32 strongyloidiasis 9.6
33 listeriosis 9.6
34 neurogenic bladder 9.6
35 hemolytic-uremic syndrome 9.6
36 polyneuropathy 9.6
37 generalized anxiety disorder 9.6
38 dermatitis 9.6
39 melancholia 9.6
40 hairy cell leukemia 9.6
41 myelitis 9.6
42 arthropathy 9.6
43 myopathy 9.6
44 peripheral nervous system disease 9.6
45 thyroiditis 9.6
46 myeloid leukemia 9.6
47 neuropathy 9.6
48 staphyloenterotoxemia 9.6
49 myxozoa 9.6
50 properdin deficiency 9.6

Graphical network of the top 20 diseases related to Myelopathy, Htlv-1-Associated:



Diseases related to Myelopathy, Htlv-1-Associated

Symptoms & Phenotypes for Myelopathy, Htlv-1-Associated

Symptoms via clinical synopsis from OMIM:

57
Neuro:
tropical spastic paraparesis
myelopathy
pyramidal signs
mild or no sensory disturbance

Lab:
anti-htlv-i antibodies in both serum and csf


Clinical features from OMIM:

159580

Human phenotypes related to Myelopathy, Htlv-1-Associated:

32
# Description HPO Frequency HPO Source Accession
1 myelopathy 32 HP:0002196
2 spastic paraparesis 32 HP:0002313
3 abnormal pyramidal signs 32 HP:0007256

Drugs & Therapeutics for Myelopathy, Htlv-1-Associated

Drugs for Myelopathy, Htlv-1-Associated (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lamivudine Approved, Investigational Phase 2, Phase 3 134678-17-4 60825
2
Zidovudine Approved Phase 2, Phase 3,Early Phase 1 30516-87-1 35370
3
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
4
Valproic Acid Approved, Investigational Phase 3,Not Applicable 99-66-1 3121
5
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
6 Anti-HIV Agents Phase 2, Phase 3,Early Phase 1
7 Anti-Infective Agents Phase 2, Phase 3,Phase 3,Early Phase 1
8 Antimetabolites Phase 2, Phase 3,Early Phase 1
9 Anti-Retroviral Agents Phase 2, Phase 3,Early Phase 1
10 Antiviral Agents Phase 2, Phase 3,Early Phase 1
11 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3,Early Phase 1
12 Reverse Transcriptase Inhibitors Phase 2, Phase 3,Early Phase 1
13 Antifungal Agents Phase 2, Phase 3
14 Antirheumatic Agents Phase 2, Phase 3
15 Calcineurin Inhibitors Phase 2, Phase 3
16 Cyclosporins Phase 2, Phase 3
17 Dermatologic Agents Phase 2, Phase 3
18 Immunosuppressive Agents Phase 2, Phase 3
19 Anticonvulsants Phase 3,Not Applicable
20 Antimanic Agents Phase 3,Not Applicable
21 Central Nervous System Depressants Phase 3,Not Applicable
22 GABA Agents Phase 3,Not Applicable
23 Neurotransmitter Agents Phase 3,Not Applicable
24 Psychotropic Drugs Phase 3,Not Applicable
25 Tranquilizing Agents Phase 3,Not Applicable
26 Antioxidants Phase 3
27 Phosphodiesterase Inhibitors Phase 3
28 Platelet Aggregation Inhibitors Phase 3
29 Protective Agents Phase 3
30 Radiation-Protective Agents Phase 3
31 Vasodilator Agents Phase 3
32
Interferon beta-1a Approved, Investigational Phase 2 145258-61-3 6438354
33
Infliximab Approved Phase 2 170277-31-3
34 Adjuvants, Immunologic Phase 2
35 Interferon-beta Phase 2
36 interferons Phase 2
37 Gastrointestinal Agents Phase 2
38 Antibodies Phase 1
39 Antibodies, Monoclonal Phase 1
40 Immunoglobulins Phase 1
41 HIV Integrase Inhibitors Early Phase 1
42 Integrase Inhibitors Early Phase 1
43 Raltegravir Potassium Early Phase 1

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Active, not recruiting NCT03226119 Phase 4
2 Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Unknown status NCT01343355 Phase 2, Phase 3 Tamibarotene
3 Zidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised Trial Completed NCT00272480 Phase 2, Phase 3 Zidovudine/lamivudine
4 Ciclosporin in HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Completed NCT00773292 Phase 2, Phase 3 ciclosporin
5 Use Of Valproid Acid To Treat Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM) Completed NCT00681980 Phase 3 Valproic acid;costicosteroids;valproid acid plus corticosteroids
6 Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) Diseases Completed NCT01472263 Phase 3 Pentoxifylline;Placebo
7 A Study of KW-0761 in Subjects With HTLV-1 Associated Myelopathy (HAM) Active, not recruiting NCT03191526 Phase 3 KW-0761 0.3 mg/kg IV;Placebo (saline)
8 Recombinant Human Interferon Beta-1a (Avonex) for the Treatment of Patients With HTLV-1-Associated Myelopathy (HAM) Completed NCT00001785 Phase 2 Recombinant human interferon beta-1a
9 The HAM Infliximab Study Terminated NCT00823641 Phase 2 Infliximab
10 Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Completed NCT00076843 Phase 1 Hu MiK-Beta-1
11 Immunotherapy of Natural Killer(NK) Cells in Human T Lymphotropic Virus Type 1(HTLV-1) Associated Myelopathy(HAM) Recruiting NCT02961712 Phase 1
12 Urological Physical Therapy in HTLV-1 With Urinary Symptoms Unknown status NCT01651819 Not Applicable
13 Evaluation of the MP Diagnostics HTLV Blot 2.4 Unknown status NCT01467024
14 MRI Brain Studies in Patients With HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis Completed NCT00034723
15 A Study of Familial and Genetic Aspects of Adult T-Cell: Leukemia/Lymphoma , Tropical Spastic Paraparesis, and Infective Dermatitis Completed NCT00340821
16 Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1 Completed NCT01754311
17 Assessment of Patients With Multiple Sclerosis (MS) Completed NCT00001156
18 Dual Algorithm Post Market Clinical Study Completed NCT03146013
19 Effect of Raltegravir in Patients With Acute Tropical Spastic Paraparesis - Human T-Lymphotropic Virus 1 Infection Recruiting NCT02655471 Early Phase 1 "Raltegravir" and "Zidovudine"
20 Evaluation of Patients With HAM/TSP Recruiting NCT00001778
21 Raltegravir for HAM/TSP Active, not recruiting NCT01867320 Early Phase 1 Raltegravir
22 Safety and Efficiency Study of Valproic Acid In HAM/TSP Terminated NCT00519181 Not Applicable Valproic Acid

Search NIH Clinical Center for Myelopathy, Htlv-1-Associated

Genetic Tests for Myelopathy, Htlv-1-Associated

Anatomical Context for Myelopathy, Htlv-1-Associated

MalaCards organs/tissues related to Myelopathy, Htlv-1-Associated:

41
T Cells, Skin, Eye, Lung, Spinal Cord, Brain, Nk Cells

Publications for Myelopathy, Htlv-1-Associated

Articles related to Myelopathy, Htlv-1-Associated:

(show top 50) (show all 424)
# Title Authors Year
1
Balance, functional mobility, and fall occurrence in patients with human T-cell lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis: a cross-sectional study. ( 29768548 )
2018
2
Role of Integrin Signaling Activation on the Development of Human T-Cell Leukemia VIrus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis: Its Relationship to HTLV-1-infected CD4+ T Cell Transmigrating Activity into the Tissues. ( 29400072 )
2018
3
Temporal trends in Human T-Lymphotropic virus 1 (HTLV-1) associated myelopathy/tropical spastic paraparesis (HAM/TSP) incidence in Martinique over 25 years (1986-2010). ( 29554087 )
2018
4
Early Juvenile HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP): Study of 25 Patients. ( 29912303 )
2018
5
Prosultiamine for treatment of lower urinary tract dysfunction accompanied by human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis. ( 28965354 )
2018
6
Role of IL-21 in HTLV-1 infections with emphasis on HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 28378248 )
2017
7
Modulatory effects of curcumin on apoptosis and cytotoxicity-related molecules in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. ( 27894665 )
2017
8
Effectiveness of Daily Prednisolone to Slow Progression of Human T-Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis: A Multicenter Retrospective Cohort Study. ( 28536850 )
2017
9
Effects of host restriction factors and the HTLV-1 subtype on susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 28420387 )
2017
10
Evaluation of T Regulatory Lymphocytes Transcription Factors in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) Patients. ( 28101786 )
2017
11
Clinical and laboratory features of HTLV-I asymptomatic carriers and patients with HTLV-I-associated myelopathy/tropical spastic paraparesis from the Brazilian Amazon. ( 28380116 )
2017
12
Indigenous tropical spastic paraparesis in Madrid (Spain). Experience on screening of human T-lymphotropic virus. ( 26282070 )
2017
13
Multiple spotty lesions of the spinal cord in a Chinese patient with human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis. ( 29292042 )
2017
14
The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 29202792 )
2017
15
Early Onset of HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) and Adult T-cell Leukemia/Lymphoma (ATL): Systematic Search and Review. ( 28582585 )
2017
16
IL17A Polymorphism Is Not Associated with Human T-Lymphotropic Virus 1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 28410448 )
2017
17
Cytoplasmic Localization of HTLV-1 HBZ Protein: A Biomarker of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). ( 28095504 )
2017
18
Mediators Go Together: High Production of CXCL9, CXCL10, IFN-I^, and TNF-I+ in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 28648091 )
2017
19
Human T-Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis: The First Case Report in Southeast Asia. ( 28343405 )
2017
20
The effect of HTLV-1 virulence factors (HBZ, Tax, proviral load), HLA class I and plasma neopterin on manifestation of HTLV-1 associated myelopathy tropical spastic paraparesis. ( 27845163 )
2017
21
Correction: Familial Clusters of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 27028551 )
2016
22
Two Cases of Human T-Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis Caused by Living-Donor Renal Transplantation. ( 27777805 )
2016
23
HLA-G 3' untranslated region polymorphisms are associated with HTLV-1 infection, proviral load and HTLV-associated myelopathy/tropical spastic paraparesis development. ( 27449667 )
2016
24
Retrospective clinic and urodynamic study in the neurogenic bladder dysfunction caused by human T cell lymphotrophic virus type 1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 26756420 )
2016
25
Clonus Associated with Tropical Spastic Paraparesis. ( 27783915 )
2016
26
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): A comparative study to identify factors that influence disease progression. ( 27871430 )
2016
27
Electrophysiological Analysis Shows Dizziness as the First Symptom in Human T Cell Lymphotropic Virus Type-Associated Myelopathy/Tropical Spastic Paraparesis. ( 25760424 )
2015
28
Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 25820278 )
2015
29
Hypometabolism of watershed areas of the brain in HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26156876 )
2015
30
High IFN-I^/IL-10 Expression Ratio and Increased Frequency of Persistent Human T-Cell Lymphotropic Virus Type 1-Infected Clones Are Associated with Human T-Cell Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis Development. ( 25833232 )
2015
31
Neurological manifestations in individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis in the Amazon. ( 26169165 )
2015
32
Common I^-chain blocking peptide reduces in vitro immune activation markers in HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26283355 )
2015
33
Neurological Manifestations in Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)-Infected Individuals Without HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Longitudinal Cohort Study. ( 25820277 )
2015
34
Human T-lymphotropic virus 1 (HTLV-1)-associated lichenoid dermatitis induced by CD8(+) T cells in HTLV-1 carrier, HTLV-1-associated myelopathy/tropical spastic paraparesis and adult T-cell leukemia/lymphoma. ( 26077665 )
2015
35
Postrenal Transplant Human T-Cell Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis: A Case Report and Review of the Literature. ( 27500208 )
2015
36
HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 27188208 )
2015
37
Deep Sequencing Analysis of Human T Cell Lymphotropic Virus Type 1 Long Terminal Repeat 5' Region from Patients with Tropical Spastic Paraparesis/Human T Cell Lymphotropic Virus Type 1-Associated Myelopathy and Asymptomatic Carriers. ( 26472535 )
2015
38
Tax secretion from peripheral blood mononuclear cells and tax detection in plasma of patients with human T-lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis and asymptomatic carriers. ( 26241614 )
2015
39
Triple Therapy with Prednisolone, Pegylated Interferon and Sodium Valproate Improves Clinical Outcome and Reduces Human T-Cell Leukemia Virus Type 1 (HTLV-1) Proviral Load, Tax and HBZ mRNA Expression in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 26174324 )
2015
40
HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Is Not Associated with SNP rs12979860 of the IL-28B Gene. ( 26609200 )
2015
41
Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 25884435 )
2015
42
Visualization of HTLV-1-specific cytotoxic T lymphocytes in the spinal cords of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 25470342 )
2015
43
A Peruvian family with a high burden of HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26392440 )
2015
44
Immunopathogenesis of HTLV-1-assoaciated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 24704970 )
2014
45
Interferon beta-1a treatment in HTLV-1-associated myelopathy/tropical spastic paraparesis: a case report. ( 25229227 )
2014
46
Proprioceptive neuromuscular facilitation in HTLV-I-associated myelopathy/tropical spastic paraparesis. ( 24603733 )
2014
47
Familial clusters of HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 24802839 )
2014
48
HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis: Semiautomatic Quantification of Spinal Cord Atrophy from 3-Dimensional MR Images. ( 22303896 )
2014
49
CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis. ( 24472094 )
2014
50
Temporal lesions and widespread involvement of white matter associated with multi-organ inflammatory disease in human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 24815740 )
2014

Variations for Myelopathy, Htlv-1-Associated

Expression for Myelopathy, Htlv-1-Associated

Search GEO for disease gene expression data for Myelopathy, Htlv-1-Associated.

Pathways for Myelopathy, Htlv-1-Associated

Pathways related to Myelopathy, Htlv-1-Associated according to KEGG:

37
# Name Kegg Source Accession
1 HTLV-I infection hsa05166

GO Terms for Myelopathy, Htlv-1-Associated

Cellular components related to Myelopathy, Htlv-1-Associated according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 8.96 CNTN2 FASLG
2 cell surface GO:0009986 8.62 CNTN2 FASLG

Sources for Myelopathy, Htlv-1-Associated

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