MCID: MYL002
MIFTS: 33

Myelophthisic Anemia

Categories: Blood diseases, Bone diseases, Immune diseases

Aliases & Classifications for Myelophthisic Anemia

MalaCards integrated aliases for Myelophthisic Anemia:

Name: Myelophthisic Anemia 12 15 17
Myelophthisis 12 70
Anemia, Leukoerythroblastic 12
Anemia Leukoerythroblastic 12
Leukoerythroblastic Anemia 70
Leukoerythroblastosis 12
Anemia, Myelophthisic 44

Classifications:



External Ids:

Disease Ontology 12 DOID:2354
MeSH 44 D000750
SNOMED-CT 67 2694001
ICD10 32 D61.82
UMLS 70 C0002890 C0302112

Summaries for Myelophthisic Anemia

Disease Ontology : 12 An aplastic anemia that is characterized by displacement of hemopoietic bone-marrow tissue either by fibrosis, tumors or granulomas.

MalaCards based summary : Myelophthisic Anemia, also known as myelophthisis, is related to juvenile myelomonocytic leukemia and splenomegaly. An important gene associated with Myelophthisic Anemia is U2AF1 (U2 Small Nuclear RNA Auxiliary Factor 1), and among its related pathways/superpathways are Kit receptor signaling pathway and Factors involved in megakaryocyte development and platelet production. Affiliated tissues include bone marrow, bone and myeloid, and related phenotypes are cellular and hematopoietic system

Wikipedia : 73 Myelophthisic anemia (or myelophthisis) is a severe type of anemia found in some people with diseases... more...

Related Diseases for Myelophthisic Anemia

Diseases related to Myelophthisic Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 juvenile myelomonocytic leukemia 30.0 U2AF1 JAK2 ASXL1
2 splenomegaly 29.8 MPL JAK2 EPO
3 polycythemia vera 29.4 U2AF1 MPL JAK2 EPO CALR ASXL1
4 polycythemia 29.2 SH2B3 MPL JAK2 EPO CALR ABL1
5 thrombocytopenia 29.0 U2AF1 MPL JAK2 HP EPO CD34
6 leukemia, chronic lymphocytic 29.0 U2AF1 JAK2 CD34 CD33 ABL1
7 thrombocytosis 28.7 SH2B3 MPL JAK2 EPO CALR ASXL1
8 deficiency anemia 28.6 U2AF1 SH2B3 MPL JAK2 HP EPO
9 pancytopenia 28.5 U2AF1 MPL HP EPO CD34 CD33
10 myeloproliferative neoplasm 28.5 U2AF1 SH2B3 MPL JAK2 EPO CALR
11 myelofibrosis 28.3 U2AF1 SH2B3 MPL JAK2 EPO CD34
12 ghosal hematodiaphyseal dysplasia 11.1
13 basal cell carcinoma 10.3
14 b-lymphoblastic leukemia/lymphoma, bcr-abl1-like 10.3 JAK2 ABL1
15 wernicke encephalopathy 10.2 U2AF1 JAK2
16 lymphoblastic leukemia, acute, with lymphomatous features 10.2 JAK2 ABL1
17 refractory cytopenia with multilineage dysplasia 10.2 U2AF1 ASXL1
18 mental retardation, autosomal dominant 33 10.2 JAK2 ABL1
19 neutrophilia, hereditary 10.2 U2AF1 JAK2
20 acute erythroid leukemia 10.2 JAK2 EPO
21 indolent systemic mastocytosis 10.2 U2AF1 ASXL1
22 b-cell adult acute lymphocytic leukemia 10.2 ANPEP ABL1
23 acquired von willebrand syndrome 10.2 U2AF1 JAK2 CALR
24 primary polycythemia 10.1 JAK2 EPO
25 sm-ahnmd 10.1 U2AF1 JAK2 ASXL1
26 myeloid and lymphoid neoplasms associated with pdgfra rearrangement 10.1 JAK2 EPO ABL1
27 portal vein thrombosis 10.1 MPL JAK2 CALR
28 patau syndrome 10.1 U2AF1 ASXL1
29 budd-chiari syndrome 10.1 MPL JAK2 CALR
30 evans' syndrome 10.1 MPL HP
31 vitamin b12 deficiency 10.1
32 aleukemic leukemia cutis 10.1 CD33 ANPEP
33 primary thrombocytopenia 10.1 MPL HP
34 breast rhabdomyosarcoma 10.0 CD33 ANPEP
35 epiglottis cancer 10.0 EPO CD34
36 hemosiderosis 10.0 U2AF1 HP EPO
37 hypercholesterolemia, familial, 1 10.0
38 familial hypercholesterolemia 10.0
39 rhabdomyosarcoma 10.0
40 purpura 10.0
41 liposarcoma 10.0
42 skin carcinoma 10.0
43 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.0
44 dendritic cell deficiency 10.0 U2AF1L4 U2AF1 ASXL1
45 chronic eosinophilic leukemia 10.0 U2AF1 JAK2 ASXL1 ABL1
46 osteopetrosis 10.0
47 adenocarcinoma 10.0
48 gastric adenocarcinoma 10.0
49 hemolytic anemia 10.0
50 hematologic cancer 9.9 U2AF1 MPL JAK2 ABL1

Graphical network of the top 20 diseases related to Myelophthisic Anemia:



Diseases related to Myelophthisic Anemia

Symptoms & Phenotypes for Myelophthisic Anemia

MGI Mouse Phenotypes related to Myelophthisic Anemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.81 ABL1 ASXL1 CALR CD34 EPO HP
2 hematopoietic system MP:0005397 9.61 ABL1 ANPEP ASXL1 CD34 EPO HP
3 immune system MP:0005387 9.28 ABL1 ANPEP ASXL1 CD34 EPO HP

Drugs & Therapeutics for Myelophthisic Anemia

Search Clinical Trials , NIH Clinical Center for Myelophthisic Anemia

Cochrane evidence based reviews: anemia, myelophthisic

Genetic Tests for Myelophthisic Anemia

Anatomical Context for Myelophthisic Anemia

MalaCards organs/tissues related to Myelophthisic Anemia:

40
Bone Marrow, Bone, Myeloid, Prostate, Breast, Skin, Pancreas

Publications for Myelophthisic Anemia

Articles related to Myelophthisic Anemia:

(show top 50) (show all 61)
# Title Authors PMID Year
1
Access to Palliative Care Services and Clinical Outcomes of Patients With Solid Malignancy-Associated Myelophthisis in a Resource-Limited Setting. 61
33161730 2020
2
Exceptional Response to Pembrolizumab in a Patient With Castration-Resistant Prostate Cancer With Pancytopenia From Myelophthisis. 61
30964731 2019
3
[Myelophthisis and gastric cancer. An unusual association]. 61
31487252 2019
4
Myelophthisic Anemia in a Patient with Lobular Breast Carcinoma Metastasized to the Bone Marrow. 61
30648074 2018
5
An elderly man with hemolysis and myelophthisic anemia. 61
28697949 2018
6
Response after treatment with pembrolizumab in a patient with myelophthisis due to melanoma: the role of checkpoint inhibition in the bone. 61
28428883 2017
7
Bone Marrow Metastases from a 1p/19q Co-deleted Oligodendroglioma - A Case Report. 61
27466523 2016
8
[Myelophthisis and kasabach merrit syndrome as initial manifestation of splenic angiosarcoma]. 61
28152371 2016
9
Metastatic Breast Cancer with Extensive Osseous Metastasis Presenting with Symptomatic Immune Thrombocytopenic Purpura and Anemia: A Case Report and Review of the Literature. 61
26120311 2015
10
Signet ring cell carcinoma's myelophthisis. 61
24623544 2014
11
The molecular signature of the stroma response in prostate cancer-induced osteoblastic bone metastasis highlights expansion of hematopoietic and prostate epithelial stem cell niches. 61
25485970 2014
12
Case of metastatic basal cell carcinoma to bone marrow, resulting in myelophthisic anemia. 61
23147353 2013
13
Myelophthisis as first manifestation of failure of chemotherapy in breast cancer. 61
23049429 2012
14
Myelophthisis in breast cancer. 61
21181955 2011
15
Ghosal hematodiaphyseal dysplasia: a rare cause of a myelophthisic anemia. 61
20672367 2010
16
Osteopetrosis-associated osteomyelitis of the jaws: a report of 4 cases. 61
19716493 2009
17
Osteopetrosis: a rare cause of anemia--review of literature. 61
19679962 2009
18
Erroneous administration of vinblastine. 61
19306070 2009
19
Bone marrow necrosis and myelophthisis: manifestations of T-cell lymphoma in a horse. 61
19055575 2008
20
High number of circulating CD34+ cells in patients with myelophthisis. 61
15996935 2005
21
Pharmacological management of aseptic osteonecrosis in children. 61
15212596 2004
22
Clinical spectrum of myelophthisis in cancer patients. 61
15114608 2004
23
Primary autoimmune myelofibrosis: definition of a distinct clinicopathologic syndrome. 61
12508261 2003
24
Clinical commentary: granulocytic fragments in sepsis. 61
11688847 2001
25
Myelophthisis as a solitary manifestation of failure from rectal carcinoma. A Batson phenomenon? 61
10923090 2000
26
Sub-super bone scan caused by bone marrow involvement of prostate cancer. 61
10582806 1999
27
Metastatic ependymoma manifested by pancytopenia. 61
7973926 1994
28
Osteopetrosis. Current clinical considerations. 61
8358940 1993
29
Hematuria and extreme neutrophilic leukocytosis in a dog with renal tubular carcinoma. 61
3391853 1988
30
Familial hypercholesterolemia with unusual foamy histiocytes. Report of a case with myelophthisic anemia and xanthoma of the maxillary sinus. 61
3354509 1988
31
Giant basal cell carcinoma with metastases and myelophthisic anemia. 61
3784556 1986
32
Kaposi's sarcoma of the bone marrow. 61
3778127 1986
33
Pancytopenia and hepatosplenomegaly in oxalosis. 61
6691753 1984
34
Diffuse nonsecretory osteosclerotic myeloma with extensive erythrophagocytosis. 61
6858968 1983
35
Mechanisms of abnormal erythropoiesis in malignancy. 61
6821869 1983
36
Metastatic basal cell carcinoma of the skin. Metastasis to the skeletal system producing myelophthisic anemia. 61
7142473 1982
37
Liposarcoma metastatic to bone marrow presenting as myelophthisic anemia: a case report. 61
7351015 1980
38
Sarcoma with myelophthisic anemia: report of two cases. 61
723797 1978
39
Oxalosis. An unusual cause of myelophthisis in childhood. 61
998570 1976
40
[Assessment of granulopoietic function reserve of the bone marrow by means of the Pyrecol-test in granulocytopenias, immature-cell leukoses and patients under antineoplastic agent therapy]. 61
997668 1976
41
Acute myelomonocytic leukemia manifested as myelophthisic anemia in a dog. 61
1066343 1976
42
Diminished bone marrow responsiveness to erythropoietin in myelophthisic anemia. 61
1260653 1976
43
Anemia associated with feline leukemia virus infection in cats. 61
163317 1975
44
[Metastasizing cutaneous basocellular carcinoma with myelophthisic anemia]. 61
5502972 1970
45
[Case of myelophthisis due to cancer of the stomach presenting renal bleeding and thrombocytopenia]. 61
5803150 1969
46
Metastasizing basal cell carcinoma of the skin with myelophthisic anemia. 61
5212310 1968
47
Myelophthisic anemia resulting from carcinoma of the pancreas: a case report. 61
6040711 1967
48
ACQUIRED ACANTHOCYTOSIS AND MYELOPHTHISIS IN A CASE OF EALES'S DISEASE. 61
14188350 1963
49
Whole body scanning in medicine. II. Clinical aspects. 61
13913237 1962
50
Primary myelofibrosis. (normocytic myelophthisic anemia). Review and case presentation. 61
13704495 1961

Variations for Myelophthisic Anemia

Expression for Myelophthisic Anemia

Search GEO for disease gene expression data for Myelophthisic Anemia.

Pathways for Myelophthisic Anemia

GO Terms for Myelophthisic Anemia

Cellular components related to Myelophthisic Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.56 CD34 CD33 CALR ANPEP
2 cell surface GO:0009986 9.35 MPL EPO CD34 CD33 CALR
3 endocytic vesicle lumen GO:0071682 9.16 HP CALR
4 U2AF GO:0089701 8.62 U2AF1L4 U2AF1

Biological processes related to Myelophthisic Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of Ras protein signal transduction GO:0046579 9.4 JAK2 EPO
2 platelet-derived growth factor receptor signaling pathway GO:0048008 9.37 JAK2 ABL1
3 hemopoiesis GO:0030097 9.33 SH2B3 CD34 ASXL1
4 negative regulation of cell-cell adhesion GO:0022408 9.32 JAK2 ABL1
5 neutrophil homeostasis GO:0001780 9.26 SH2B3 MPL
6 thrombopoietin-mediated signaling pathway GO:0038163 8.96 SH2B3 MPL
7 monocyte homeostasis GO:0035702 8.62 SH2B3 MPL

Molecular functions related to Myelophthisic Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 9.13 CD34 CD33 CALR
2 pre-mRNA 3'-splice site binding GO:0030628 8.62 U2AF1L4 U2AF1

Sources for Myelophthisic Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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