MCID: MYL002
MIFTS: 32

Myelophthisic Anemia

Categories: Blood diseases

Aliases & Classifications for Myelophthisic Anemia

MalaCards integrated aliases for Myelophthisic Anemia:

Name: Myelophthisic Anemia 12 15
Myelophthisis 12 73
Anemia, Leukoerythroblastic 12
Anemia Leukoerythroblastic 12
Leukoerythroblastic Anemia 73
Leukoerythroblastosis 12
Anemia, Myelophthisic 44

Classifications:



External Ids:

Disease Ontology 12 DOID:2354
ICD10 33 D61.82
MeSH 44 D000750
NCIt 50 C36218
SNOMED-CT 68 2694001

Summaries for Myelophthisic Anemia

Disease Ontology : 12 An aplastic anemia that is characterized by displacement of hemopoietic bone-marrow tissue either by fibrosis, tumors or granulomas.

MalaCards based summary : Myelophthisic Anemia, also known as myelophthisis, is related to basal cell carcinoma 1 and basal cell carcinoma. An important gene associated with Myelophthisic Anemia is JAK2 (Janus Kinase 2), and among its related pathways/superpathways are Immune response IL-2 activation and signaling pathway and Visual Cycle in Retinal Rods. Affiliated tissues include bone marrow, bone and prostate, and related phenotype is liver/biliary system.

Wikipedia : 76 Myelophthisic anemia (or myelophthisis) is a severe type of anemia found in some people with diseases... more...

Related Diseases for Myelophthisic Anemia

Graphical network of the top 20 diseases related to Myelophthisic Anemia:



Diseases related to Myelophthisic Anemia

Symptoms & Phenotypes for Myelophthisic Anemia

MGI Mouse Phenotypes related to Myelophthisic Anemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 8.92 EPHA3 HP JAK2 PTPN11

Drugs & Therapeutics for Myelophthisic Anemia

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2 Study Of PRM-151 In Subjects With Myelofibrosis Active, not recruiting NCT01981850 Phase 2

Search NIH Clinical Center for Myelophthisic Anemia

Cochrane evidence based reviews: anemia, myelophthisic

Genetic Tests for Myelophthisic Anemia

Anatomical Context for Myelophthisic Anemia

MalaCards organs/tissues related to Myelophthisic Anemia:

41
Bone Marrow, Bone, Prostate, Skin, Pancreas

Publications for Myelophthisic Anemia

Articles related to Myelophthisic Anemia:

(show all 19)
# Title Authors Year
1
An elderly man with hemolysis and myelophthisic anemia. ( 28697949 )
2017
2
Case of metastatic basal cell carcinoma to bone marrow, resulting in myelophthisic anemia. ( 23147353 )
2013
3
Ghosal hematodiaphyseal dysplasia: a rare cause of a myelophthisic anemia. ( 20672367 )
2010
4
Familial hypercholesterolemia with unusual foamy histiocytes. Report of a case with myelophthisic anemia and xanthoma of the maxillary sinus. ( 3354509 )
1988
5
Giant basal cell carcinoma with metastases and myelophthisic anemia. ( 3784556 )
1986
6
Metastatic basal cell carcinoma of the skin. Metastasis to the skeletal system producing myelophthisic anemia. ( 7142473 )
1982
7
Liposarcoma metastatic to bone marrow presenting as myelophthisic anemia: a case report. ( 7351015 )
1980
8
Sarcoma with myelophthisic anemia: report of two cases. ( 723797 )
1978
9
Diminished bone marrow responsiveness to erythropoietin in myelophthisic anemia. ( 1260653 )
1976
10
Acute myelomonocytic leukemia manifested as myelophthisic anemia in a dog. ( 1066343 )
1976
11
Metastasizing basal cell carcinoma of the skin with myelophthisic anemia. ( 5212310 )
1968
12
Myelophthisic anemia resulting from carcinoma of the pancreas: a case report. ( 6040711 )
1967
13
Primary myelofibrosis. (normocytic myelophthisic anemia). Review and case presentation. ( 13704495 )
1961
14
Myelophthisic anemia in cancer of the breast. ( 14376412 )
1955
15
Myelophthisic anemia as terminal stage of polycythemia vera; protracted x-ray treatment followed by a myelosclerotic syndrome. ( 14932790 )
1952
16
Metastases in bone marrow and myelophthisic anemia from carcinoma of the prostate. ( 18137147 )
1949
17
Carcinoma of stomach with myelophthisic anemia and thrombocytopenia. ( 18870550 )
1948
18
Myelophthisic anemia the presenting manifestation of prostatic carcinoma with skeletal metastases; the effect of castration and stilbestrol. ( 18101771 )
1948
19
The effect of castration and di-ethyl stilboestrol in a patient with myelophthisic anemia secondary to carcinoma of the prostate. ( 20272558 )
1947

Variations for Myelophthisic Anemia

Expression for Myelophthisic Anemia

Search GEO for disease gene expression data for Myelophthisic Anemia.

Pathways for Myelophthisic Anemia

GO Terms for Myelophthisic Anemia

Biological processes related to Myelophthisic Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ephrin receptor signaling pathway GO:0048013 9.26 EPHA3 PTPN11
2 hormone-mediated signaling pathway GO:0009755 9.16 JAK2 PTPN11
3 platelet-derived growth factor receptor signaling pathway GO:0048008 8.96 JAK2 PTPN11
4 interleukin-6-mediated signaling pathway GO:0070102 8.62 JAK2 PTPN11

Molecular functions related to Myelophthisic Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor substrate binding GO:0043560 8.96 JAK2 PTPN11
2 peptide hormone receptor binding GO:0051428 8.62 JAK2 PTPN11

Sources for Myelophthisic Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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