MCID: MYL002
MIFTS: 35

Myelophthisic Anemia

Categories: Blood diseases, Bone diseases, Immune diseases

Aliases & Classifications for Myelophthisic Anemia

MalaCards integrated aliases for Myelophthisic Anemia:

Name: Myelophthisic Anemia 12 15
Myelophthisis 12 73
Anemia, Leukoerythroblastic 12
Anemia Leukoerythroblastic 12
Leukoerythroblastic Anemia 73
Leukoerythroblastosis 12
Anemia, Myelophthisic 44

Classifications:



External Ids:

Disease Ontology 12 DOID:2354
ICD10 33 D61.82
MeSH 44 D000750
NCIt 50 C36218
SNOMED-CT 68 2694001

Summaries for Myelophthisic Anemia

Disease Ontology : 12 An aplastic anemia that is characterized by displacement of hemopoietic bone-marrow tissue either by fibrosis, tumors or granulomas.

MalaCards based summary : Myelophthisic Anemia, also known as myelophthisis, is related to basal cell carcinoma 1 and basal cell carcinoma. An important gene associated with Myelophthisic Anemia is JAK2 (Janus Kinase 2), and among its related pathways/superpathways are Innate Immune System and Development EPO-induced Jak-STAT pathway. Affiliated tissues include bone, bone marrow and prostate, and related phenotype is liver/biliary system.

Wikipedia : 76 Myelophthisic anemia (or myelophthisis) is a severe type of anemia found in some people with diseases... more...

Related Diseases for Myelophthisic Anemia

Diseases related to Myelophthisic Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 basal cell carcinoma 1 10.3
2 basal cell carcinoma 10.3
3 adenocarcinoma 10.2
4 breast cancer 10.2
5 vitamin b12 deficiency 10.1
6 pancytopenia 10.1
7 gastric adenocarcinoma 10.1
8 lymphoma 10.0
9 melanoma 10.0
10 bone marrow necrosis 10.0
11 aleukemic leukemia cutis 10.0 CD33 ANPEP
12 hypercholesterolemia, familial 10.0
13 ghosal hematodiaphyseal dysplasia 10.0
14 myelofibrosis 10.0
15 polycythemia vera 10.0
16 leukemia 10.0
17 thrombocytopenia 10.0
18 sarcoma 10.0
19 liposarcoma 10.0
20 polycythemia 10.0
21 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.0
22 hepatic vascular disease 10.0 JAK2 CD33
23 lung cancer susceptibility 3 10.0
24 alcoholic hepatitis 10.0
25 hemolytic anemia 10.0
26 hepatitis 10.0
27 splenomegaly 10.0
28 precursor t-cell acute lymphoblastic leukemia 9.9 CD33 ANPEP
29 myelodysplastic myeloproliferative cancer 9.9 PTPN11 JAK2
30 acute leukemia 9.9 JAK2 CD33 ANPEP
31 myeloproliferative neoplasm 9.9 PTPN11 JAK2
32 severe congenital neutropenia 9.9 PTPN11 JAK2
33 myeloproliferative syndrome, transient 9.9 PTPN11 CD33
34 congenital disorder of glycosylation, type in 9.8 HP ATP6V0A2
35 chronic myelomonocytic leukemia 9.8 PTPN11 JAK2
36 bone marrow cancer 9.8 PTPN11 JAK2 ANPEP
37 hematologic cancer 9.7 PTPN11 JAK2 CD33
38 myeloid leukemia 9.7 PTPN11 JAK2 CD33
39 leukemia, acute myeloid 9.6 PTPN11 JAK2 CD33 ANPEP
40 myelodysplastic syndrome 9.6 PTPN11 JAK2 CD33 ANPEP

Graphical network of the top 20 diseases related to Myelophthisic Anemia:



Diseases related to Myelophthisic Anemia

Symptoms & Phenotypes for Myelophthisic Anemia

MGI Mouse Phenotypes related to Myelophthisic Anemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 8.92 EPHA3 HP JAK2 PTPN11

Drugs & Therapeutics for Myelophthisic Anemia

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2 Study Of PRM-151 In Subjects With Myelofibrosis Active, not recruiting NCT01981850 Phase 2

Search NIH Clinical Center for Myelophthisic Anemia

Cochrane evidence based reviews: anemia, myelophthisic

Genetic Tests for Myelophthisic Anemia

Anatomical Context for Myelophthisic Anemia

MalaCards organs/tissues related to Myelophthisic Anemia:

41
Bone, Bone Marrow, Prostate, Skin, T Cells, Lung, Myeloid

Publications for Myelophthisic Anemia

Articles related to Myelophthisic Anemia:

(show all 28)
# Title Authors Year
1
An elderly man with hemolysis and myelophthisic anemia. ( 28697949 )
2017
2
Response after treatment with pembrolizumab in a patient with myelophthisis due to melanoma: the role of checkpoint inhibition in the bone. ( 28428883 )
2017
3
Signet ring cell carcinoma's myelophthisis. ( 24623544 )
2014
4
Case of metastatic basal cell carcinoma to bone marrow, resulting in myelophthisic anemia. ( 23147353 )
2013
5
Myelophthisis as first manifestation of failure of chemotherapy in breast cancer. ( 23049429 )
2012
6
Myelophthisis in breast cancer. ( 21181955 )
2011
7
Ghosal hematodiaphyseal dysplasia: a rare cause of a myelophthisic anemia. ( 20672367 )
2010
8
Bone marrow necrosis and myelophthisis: manifestations of T-cell lymphoma in a horse. ( 19055575 )
2008
9
Clinical spectrum of myelophthisis in cancer patients. ( 15114608 )
2004
10
Myelophthisis as a solitary manifestation of failure from rectal carcinoma. A Batson phenomenon? ( 10923090 )
2000
11
Familial hypercholesterolemia with unusual foamy histiocytes. Report of a case with myelophthisic anemia and xanthoma of the maxillary sinus. ( 3354509 )
1988
12
Giant basal cell carcinoma with metastases and myelophthisic anemia. ( 3784556 )
1986
13
Metastatic basal cell carcinoma of the skin. Metastasis to the skeletal system producing myelophthisic anemia. ( 7142473 )
1982
14
Liposarcoma metastatic to bone marrow presenting as myelophthisic anemia: a case report. ( 7351015 )
1980
15
Sarcoma with myelophthisic anemia: report of two cases. ( 723797 )
1978
16
Diminished bone marrow responsiveness to erythropoietin in myelophthisic anemia. ( 1260653 )
1976
17
Acute myelomonocytic leukemia manifested as myelophthisic anemia in a dog. ( 1066343 )
1976
18
Oxalosis. An unusual cause of myelophthisis in childhood. ( 998570 )
1976
19
Metastasizing basal cell carcinoma of the skin with myelophthisic anemia. ( 5212310 )
1968
20
Myelophthisic anemia resulting from carcinoma of the pancreas: a case report. ( 6040711 )
1967
21
ACQUIRED ACANTHOCYTOSIS AND MYELOPHTHISIS IN A CASE OF EALES'S DISEASE. ( 14188350 )
1963
22
Primary myelofibrosis. (normocytic myelophthisic anemia). Review and case presentation. ( 13704495 )
1961
23
Myelophthisic anemia in cancer of the breast. ( 14376412 )
1955
24
Myelophthisic anemia as terminal stage of polycythemia vera; protracted x-ray treatment followed by a myelosclerotic syndrome. ( 14932790 )
1952
25
Metastases in bone marrow and myelophthisic anemia from carcinoma of the prostate. ( 18137147 )
1949
26
Carcinoma of stomach with myelophthisic anemia and thrombocytopenia. ( 18870550 )
1948
27
Myelophthisic anemia the presenting manifestation of prostatic carcinoma with skeletal metastases; the effect of castration and stilbestrol. ( 18101771 )
1948
28
The effect of castration and di-ethyl stilboestrol in a patient with myelophthisic anemia secondary to carcinoma of the prostate. ( 20272558 )
1947

Variations for Myelophthisic Anemia

Expression for Myelophthisic Anemia

Search GEO for disease gene expression data for Myelophthisic Anemia.

Pathways for Myelophthisic Anemia

GO Terms for Myelophthisic Anemia

Biological processes related to Myelophthisic Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.54 ANPEP CD33 HP
2 ephrin receptor signaling pathway GO:0048013 9.32 EPHA3 PTPN11
3 positive regulation of tumor necrosis factor production GO:0032760 9.26 JAK2 PTPN11
4 hormone-mediated signaling pathway GO:0009755 9.16 JAK2 PTPN11
5 platelet-derived growth factor receptor signaling pathway GO:0048008 8.96 JAK2 PTPN11
6 interleukin-6-mediated signaling pathway GO:0070102 8.62 JAK2 PTPN11

Molecular functions related to Myelophthisic Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor substrate binding GO:0043560 8.96 JAK2 PTPN11
2 peptide hormone receptor binding GO:0051428 8.62 JAK2 PTPN11

Sources for Myelophthisic Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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