MCID: MYL002
MIFTS: 34

Myelophthisic Anemia

Categories: Blood diseases, Bone diseases, Immune diseases

Aliases & Classifications for Myelophthisic Anemia

MalaCards integrated aliases for Myelophthisic Anemia:

Name: Myelophthisic Anemia 12 15 17
Myelophthisis 12 71
Anemia, Leukoerythroblastic 12
Anemia Leukoerythroblastic 12
Leukoerythroblastic Anemia 71
Leukoerythroblastosis 12
Anemia, Myelophthisic 43

Classifications:



External Ids:

Disease Ontology 12 DOID:2354
MeSH 43 D000750
SNOMED-CT 67 2694001
ICD10 32 D61.82
UMLS 71 C0002890 C0302112

Summaries for Myelophthisic Anemia

Disease Ontology : 12 An aplastic anemia that is characterized by displacement of hemopoietic bone-marrow tissue either by fibrosis, tumors or granulomas.

MalaCards based summary : Myelophthisic Anemia, also known as myelophthisis, is related to anemia, x-linked, with or without neutropenia and/or platelet abnormalities and splenomegaly. An important gene associated with Myelophthisic Anemia is U2AF1 (U2 Small Nuclear RNA Auxiliary Factor 1), and among its related pathways/superpathways are JAK-STAT signaling pathway and Transport of Mature Transcript to Cytoplasm. Affiliated tissues include bone, bone marrow and prostate, and related phenotypes are cellular and hematopoietic system

Wikipedia : 74 Myelophthisic anemia (or myelophthisis) is a severe type of anemia found in some people with diseases... more...

Related Diseases for Myelophthisic Anemia

Diseases related to Myelophthisic Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 30.8 HP EPO
2 splenomegaly 30.2 MPL JAK2 EPO
3 deficiency anemia 29.9 U2AF1 JAK2 HP EPO CD34 ANPEP
4 leukemia 29.9 U2AF1 MPL JAK2 ASXL1 ABL1
5 juvenile myelomonocytic leukemia 29.7 U2AF1 JAK2 ASXL1
6 polycythemia 29.4 SH2B3 MPL JAK2 EPO CALR
7 polycythemia vera 29.4 U2AF1 MPL JAK2 EPO CALR ASXL1
8 thrombocytopenia 28.9 U2AF1 MPL JAK2 HP EPO CD34
9 pancytopenia 28.3 U2AF1 MPL HP EPO CD34 CD33
10 myeloproliferative neoplasm 28.2 U2AF1 SH2B3 MPL JAK2 EPO CALR
11 leukemia, chronic lymphocytic 28.0 U2AF1L4 U2AF1 SRSF2 JAK2 CD34 CD33
12 myelofibrosis 27.4 U2AF1 SRSF2 SH2B3 MPL JAK2 EPO
13 ghosal hematodiaphyseal dysplasia 11.7
14 basal cell carcinoma 10.4
15 b-lymphoblastic leukemia/lymphoma, bcr-abl1-like 10.4 JAK2 ABL1
16 lymphoblastic leukemia, acute, with lymphomatous features 10.3 JAK2 ABL1
17 refractory cytopenia with multilineage dysplasia 10.3 U2AF1 ASXL1
18 acquired von willebrand syndrome 10.3 U2AF1 JAK2
19 vitamin b12 deficiency 10.3
20 mental retardation, autosomal dominant 33 10.2 JAK2 ABL1
21 retinitis pigmentosa and erythrocytic microcytosis 10.2 JAK2 EPO
22 neutrophilia, hereditary 10.2 U2AF1 JAK2
23 b-cell adult acute lymphocytic leukemia 10.2 ANPEP ABL1
24 neutropenia 10.2
25 osteopetrosis 10.2
26 adenocarcinoma 10.2
27 gastric adenocarcinoma 10.2
28 hemolytic anemia 10.2
29 splenic infarction 10.2 JAK2 HP
30 primary polycythemia 10.2 JAK2 EPO
31 portal vein thrombosis 10.1 MPL JAK2 CALR
32 myeloid and lymphoid neoplasms associated with pdgfra rearrangement 10.1 JAK2 EPO ABL1
33 systemic mastocytosis with associated hematologic neoplasm 10.1 SRSF2 ASXL1
34 breast cancer 10.1
35 hypercholesterolemia, familial, 1 10.1
36 sarcoma 10.1
37 familial hypercholesterolemia 10.1
38 rhabdomyosarcoma 10.1
39 purpura 10.1
40 liposarcoma 10.1
41 skin carcinoma 10.1
42 spindle cell sarcoma 10.1
43 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.1
44 budd-chiari syndrome 10.1 MPL JAK2 CALR
45 wernicke encephalopathy 10.1 U2AF1 JAK2
46 abetalipoproteinemia 10.1
47 pancreatic cancer 10.1
48 fanconi renotubular syndrome 2 10.1
49 gastric cancer 10.1
50 fanconi syndrome 10.1

Graphical network of the top 20 diseases related to Myelophthisic Anemia:



Diseases related to Myelophthisic Anemia

Symptoms & Phenotypes for Myelophthisic Anemia

MGI Mouse Phenotypes related to Myelophthisic Anemia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.85 ABL1 ASXL1 CALR CD34 EPO HP
2 hematopoietic system MP:0005397 9.65 ABL1 ANPEP ASXL1 CD34 EPO HP
3 immune system MP:0005387 9.32 ABL1 ANPEP ASXL1 CD34 EPO HP

Drugs & Therapeutics for Myelophthisic Anemia

Search Clinical Trials , NIH Clinical Center for Myelophthisic Anemia

Cochrane evidence based reviews: anemia, myelophthisic

Genetic Tests for Myelophthisic Anemia

Anatomical Context for Myelophthisic Anemia

MalaCards organs/tissues related to Myelophthisic Anemia:

40
Bone, Bone Marrow, Prostate, Breast, Skin, Pancreas, Testes

Publications for Myelophthisic Anemia

Articles related to Myelophthisic Anemia:

(show top 50) (show all 59)
# Title Authors PMID Year
1
Exceptional Response to Pembrolizumab in a Patient With Castration-Resistant Prostate Cancer With Pancytopenia From Myelophthisis. 61
30964731 2019
2
[Myelophthisis and gastric cancer. An unusual association]. 61
31487252 2019
3
Myelophthisic Anemia in a Patient with Lobular Breast Carcinoma Metastasized to the Bone Marrow. 61
30648074 2018
4
An elderly man with hemolysis and myelophthisic anemia. 61
28697949 2018
5
Response after treatment with pembrolizumab in a patient with myelophthisis due to melanoma: the role of checkpoint inhibition in the bone. 61
28428883 2017
6
Bone Marrow Metastases from a 1p/19q Co-deleted Oligodendroglioma - A Case Report. 61
27466523 2016
7
[Myelophthisis and kasabach merrit syndrome as initial manifestation of splenic angiosarcoma]. 61
28152371 2016
8
Metastatic Breast Cancer with Extensive Osseous Metastasis Presenting with Symptomatic Immune Thrombocytopenic Purpura and Anemia: A Case Report and Review of the Literature. 61
26120311 2015
9
Signet ring cell carcinoma's myelophthisis. 61
24623544 2014
10
The molecular signature of the stroma response in prostate cancer-induced osteoblastic bone metastasis highlights expansion of hematopoietic and prostate epithelial stem cell niches. 61
25485970 2014
11
Case of metastatic basal cell carcinoma to bone marrow, resulting in myelophthisic anemia. 61
23147353 2013
12
Myelophthisis as first manifestation of failure of chemotherapy in breast cancer. 61
23049429 2012
13
Myelophthisis in breast cancer. 61
21181955 2011
14
Ghosal hematodiaphyseal dysplasia: a rare cause of a myelophthisic anemia. 61
20672367 2010
15
Osteopetrosis-associated osteomyelitis of the jaws: a report of 4 cases. 61
19716493 2009
16
Osteopetrosis: a rare cause of anemia--review of literature. 61
19679962 2009
17
Erroneous administration of vinblastine. 61
19306070 2009
18
Bone marrow necrosis and myelophthisis: manifestations of T-cell lymphoma in a horse. 61
19055575 2008
19
High number of circulating CD34+ cells in patients with myelophthisis. 61
15996935 2005
20
Pharmacological management of aseptic osteonecrosis in children. 61
15212596 2004
21
Clinical spectrum of myelophthisis in cancer patients. 61
15114608 2004
22
Primary autoimmune myelofibrosis: definition of a distinct clinicopathologic syndrome. 61
12508261 2003
23
Clinical commentary: granulocytic fragments in sepsis. 61
11688847 2001
24
Myelophthisis as a solitary manifestation of failure from rectal carcinoma. A Batson phenomenon? 61
10923090 2000
25
Sub-super bone scan caused by bone marrow involvement of prostate cancer. 61
10582806 1999
26
Metastatic ependymoma manifested by pancytopenia. 61
7973926 1994
27
Osteopetrosis. Current clinical considerations. 61
8358940 1993
28
Hematuria and extreme neutrophilic leukocytosis in a dog with renal tubular carcinoma. 61
3391853 1988
29
Familial hypercholesterolemia with unusual foamy histiocytes. Report of a case with myelophthisic anemia and xanthoma of the maxillary sinus. 61
3354509 1988
30
Giant basal cell carcinoma with metastases and myelophthisic anemia. 61
3784556 1986
31
Kaposi's sarcoma of the bone marrow. 61
3778127 1986
32
Pancytopenia and hepatosplenomegaly in oxalosis. 61
6691753 1984
33
Diffuse nonsecretory osteosclerotic myeloma with extensive erythrophagocytosis. 61
6858968 1983
34
Mechanisms of abnormal erythropoiesis in malignancy. 61
6821869 1983
35
Metastatic basal cell carcinoma of the skin. Metastasis to the skeletal system producing myelophthisic anemia. 61
7142473 1982
36
Liposarcoma metastatic to bone marrow presenting as myelophthisic anemia: a case report. 61
7351015 1980
37
Sarcoma with myelophthisic anemia: report of two cases. 61
723797 1978
38
Oxalosis. An unusual cause of myelophthisis in childhood. 61
998570 1976
39
[Assessment of granulopoietic function reserve of the bone marrow by means of the Pyrecol-test in granulocytopenias, immature-cell leukoses and patients under antineoplastic agent therapy]. 61
997668 1976
40
Acute myelomonocytic leukemia manifested as myelophthisic anemia in a dog. 61
1066343 1976
41
Diminished bone marrow responsiveness to erythropoietin in myelophthisic anemia. 61
1260653 1976
42
Anemia associated with feline leukemia virus infection in cats. 61
163317 1975
43
[Metastasizing cutaneous basocellular carcinoma with myelophthisic anemia]. 61
5502972 1970
44
[Case of myelophthisis due to cancer of the stomach presenting renal bleeding and thrombocytopenia]. 61
5803150 1969
45
Metastasizing basal cell carcinoma of the skin with myelophthisic anemia. 61
5212310 1968
46
Myelophthisic anemia resulting from carcinoma of the pancreas: a case report. 61
6040711 1967
47
ACQUIRED ACANTHOCYTOSIS AND MYELOPHTHISIS IN A CASE OF EALES'S DISEASE. 61
14188350 1963
48
Whole body scanning in medicine. II. Clinical aspects. 61
13913237 1962
49
Primary myelofibrosis. (normocytic myelophthisic anemia). Review and case presentation. 61
13704495 1961
50
[Myelophthisic anemia with myeloid metaplasia; report of 3 cases]. 61
13581313 1958

Variations for Myelophthisic Anemia

Expression for Myelophthisic Anemia

Search GEO for disease gene expression data for Myelophthisic Anemia.

Pathways for Myelophthisic Anemia

GO Terms for Myelophthisic Anemia

Cellular components related to Myelophthisic Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.46 CD34 CD33 CALR ANPEP
2 spliceosomal complex GO:0005681 9.43 U2AF1L4 U2AF1 SRSF2
3 endocytic vesicle lumen GO:0071682 8.96 HP CALR
4 U2AF GO:0089701 8.62 U2AF1L4 U2AF1

Biological processes related to Myelophthisic Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA export from nucleus GO:0006406 9.58 U2AF1L4 U2AF1 SRSF2
2 hemopoiesis GO:0030097 9.54 SH2B3 CD34 ASXL1
3 negative regulation of cell-cell adhesion GO:0022408 9.43 JAK2 ABL1
4 RNA export from nucleus GO:0006405 9.43 U2AF1L4 U2AF1 SRSF2
5 mRNA 3'-end processing GO:0031124 9.33 U2AF1L4 U2AF1 SRSF2
6 neutrophil homeostasis GO:0001780 9.32 SH2B3 MPL
7 thrombopoietin-mediated signaling pathway GO:0038163 8.96 SH2B3 MPL
8 monocyte homeostasis GO:0035702 8.62 SH2B3 MPL

Molecular functions related to Myelophthisic Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pre-mRNA 3'-splice site binding GO:0030628 8.62 U2AF1L4 U2AF1

Sources for Myelophthisic Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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