MPE
MCID: MYL067
MIFTS: 37

Myeloproliferative Disorder, Chronic, with Eosinophilia (MPE)

Categories: Blood diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Myeloproliferative Disorder, Chronic, with Eosinophilia

MalaCards integrated aliases for Myeloproliferative Disorder, Chronic, with Eosinophilia:

Name: Myeloproliferative Disorder, Chronic, with Eosinophilia 57 40 73
Myeloproliferative Disorder with Eosinophilia 57 13
Mpe 57 75
Myeloproliferative Disorder Chronic with Eosinophilia 75
Chronic Myeloproliferative Disease, Unclassifiable 59
Undifferentiated Myeloproliferative Disease 59
Myeloproliferative Neoplasm, Unclassifiable 73
Eosinophils, Malignant Proliferation of 57
Malignant Proliferation of Eosinophils 75
Malignant Eosinophil Proliferation 29
Mpe; Emp 57
Cmpd-U 59
Emp 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant (12p13)


HPO:

32
myeloproliferative disorder, chronic, with eosinophilia:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 131440
Orphanet 59 ORPHA86830
ICD10 via Orphanet 34 D47.1
MedGen 42 C1851585
SNOMED-CT via HPO 69 263681008 414794006 425333006

Summaries for Myeloproliferative Disorder, Chronic, with Eosinophilia

UniProtKB/Swiss-Prot : 75 Myeloproliferative disorder chronic with eosinophilia: A hematologic disorder characterized by malignant eosinophils proliferation.

MalaCards based summary : Myeloproliferative Disorder, Chronic, with Eosinophilia, also known as myeloproliferative disorder with eosinophilia, is related to myeloproliferative neoplasm and pdgfrb-associated chronic eosinophilic leukemia. An important gene associated with Myeloproliferative Disorder, Chronic, with Eosinophilia is PDGFRB (Platelet Derived Growth Factor Receptor Beta). The drugs Aredia and Clolar have been mentioned in the context of this disorder. Affiliated tissues include bone, t cells and bone marrow, and related phenotypes are eosinophilia and myeloproliferative disorder

Description from OMIM: 131440

Related Diseases for Myeloproliferative Disorder, Chronic, with Eosinophilia

Diseases related to Myeloproliferative Disorder, Chronic, with Eosinophilia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)
# Related Disease Score Top Affiliating Genes
1 myeloproliferative neoplasm 11.4
2 pdgfrb-associated chronic eosinophilic leukemia 11.4
3 extramedullary plasmacytoma 10.4
4 plasmacytoma 10.4
5 benign mesothelioma 10.1
6 lung cancer susceptibility 3 10.0
7 hemopericardium 10.0
8 pericardial effusion 10.0
9 adenocarcinoma 10.0
10 breast cancer 10.0
11 prostate cancer 10.0
12 pemphigus foliaceus 10.0
13 lung disease 10.0
14 primary hypereosinophilic syndrome 9.8 PDGFRB ETV6
15 myofibroma 9.8 PDGFRB ETV6
16 chronic myelomonocytic leukemia 9.8 PDGFRB ETV6
17 bone marrow cancer 9.8 PDGFRB ETV6
18 leukemia, chronic myeloid 9.8 PDGFRB ETV6
19 hematologic cancer 9.7 PDGFRB ETV6
20 myelodysplastic syndrome 9.6 PDGFRB ETV6

Graphical network of the top 20 diseases related to Myeloproliferative Disorder, Chronic, with Eosinophilia:



Diseases related to Myeloproliferative Disorder, Chronic, with Eosinophilia

Symptoms & Phenotypes for Myeloproliferative Disorder, Chronic, with Eosinophilia

Symptoms via clinical synopsis from OMIM:

57
Oncology:
malignant eosinophil proliferation


Clinical features from OMIM:

131440

Human phenotypes related to Myeloproliferative Disorder, Chronic, with Eosinophilia:

32
# Description HPO Frequency HPO Source Accession
1 eosinophilia 32 HP:0001880
2 myeloproliferative disorder 32 HP:0005547
3 malignant eosinophil proliferation 32 HP:0006782

GenomeRNAi Phenotypes related to Myeloproliferative Disorder, Chronic, with Eosinophilia according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.53 ETV6
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.53 TP53BP1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.53 ETV6 TP53BP1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.53 ETV6
5 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.53 ETV6
6 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.53 TP53BP1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.53 ETV6
8 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.53 TP53BP1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.53 ETV6
10 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.53 ETV6
11 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.53 ETV6
12 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.53 TP53BP1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.53 ETV6
14 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.53 TP53BP1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.53 TP53BP1

MGI Mouse Phenotypes related to Myeloproliferative Disorder, Chronic, with Eosinophilia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 8.8 ETV6 PDGFRB TP53BP1

Drugs & Therapeutics for Myeloproliferative Disorder, Chronic, with Eosinophilia

FDA approved drugs:

(show all 47)
# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Aredia 18 49 PAMIDRONATE DISODIUM Chiron August 1996
2
Clolar 18 49 CLOFARABINE Genzyme December, 2004
3
Ellence 18 49 EPIRUBICIN HYDROCHLORIDE Pharmacia & Upjohn September 1999
4
Erbitux 18 49 CETUXIMAB Imclone, Bristol-Myers Squibb February 2004
5
Faslodex 18 49 FULVESTRANT AstraZeneca April 2002
6
Femara 18 49 LETROZOLE Novartis January 2001
7
Folotyn 18 49 PRALATREXATE Allos Therapeutics September 2009
8
Intron A 18 49 INTERFERON ALFA-2B Schering-Plough December 1997/ December 1995/ March 1997
9
Ixempra 18 49 IXABEPILONE Bristol-Myers Squibb October 2007
10
Odomzo 18 49 SONIDEGIB PHOSPHATE Novartis Jul-15
11
Plenaxis 18 ABARELIX Praecis Pharmaceuticals December 2003
12
Rituxan 18 49 RITUXIMAB Biogen IDEC, Genentech November 1997
13
Sutent 18 49 SUNITINIB MALATE Pfizer May 2011/ January 2006
14
Sylatron 18 49 PEGINTERFERON ALFA-2B Merck April 2011
15
Tafinlar 18 49 DABRAFENIB MESYLATE GlaxoSmithKline May 2013
16
Tarceva 18 49 ERLOTINIB HYDROCHLORIDE Genentech, OSI Pharmaceuticals November, 2004
17
UroXatral 18 ALFUZOSIN HYDROCHLORIDE Sanofi-aventis June 2003
18
Vectibix 18 49 PANITUMUMAB Amgen September 2006
19
Velcade 18 49 BORTEZOMIB Millennium Pharmaceuticals May 2003
20
Xalkori 18 49 CRIZOTINIB Pfizer August of 2011
21
Xtandi 18 49 ENZALUTAMIDE Medivation August 2012
22
Zykadia 18 49 CERITINIB Novartis April 2014
23
Zytiga 18 49 ABIRATERONE ACETATE Centocor Ortho Biotech May 2011
24
Adempas 18 RIOCIGUAT Bayer Healthcare Pharmaceuticals October 2013
25
Anoro Ellipta 18 UMECLIDINIUM BROMIDE; VILANTEROL TRIFENATATE GlaxoSmithKline December of 2013
26
Arcapta 18 INDACATEROL MALEATE Novartis July 2011
27
Biaxin XL 18 CLARITHROMYCIN Abbott Laboratories March 2000
28
Breathe Right 18 CNS June 1996
29
Breo Ellipta 18 FLUTICASONE FUROATE; VILANTEROL TRIFENATATE GlaxoSmithKline May 2013
30
Brovana 18 ARFORMOTEROL TARTRATE Sepracor in October 2006
31
Cedax 18 CEFTIBUTEN DIHYDRATE Schering-Plough December 1995
32
Ceftin 18 CEFUROXIME AXETIL GlaxoSmithKline September 1997
33
DuoNeb 18 ALBUTEROL SULFATE; IPRATROPIUM BROMIDE Dey Laboratories March 2001
34
Dymista 18 AZELASTINE HYDROCHLORIDE; FLUTICASONE PROPIONATE Meda Pharmaceuticals Inc May 2012
35
Foradil Aerolizer 18 FORMOTEROL FUMARATE Novartis February 2001 (asthma, bronchospasm); September 2001 (COPD)
36
Incruse Ellipta 18 UMECLIDINIUM BROMIDE GlaxoSmithKline May 2014
37
Ofev 18 NINTEDANIB ESYLATE Boehringer Ingelheim October 2014
38
Patanase 18 OLOPATADINE HYDROCHLORIDE Alcon April 2008
39
Pulmozyme 18 DORNASE ALFA Genentech December 1996|March 1998
40
Rhinocort Aqua Nasal Spray 18 BUDESONIDE AstraZeneca October 1999
41
Spiriva HandiHaler 18 TIOTROPIUM BROMIDE Boehringer Ingelheim February 2004
42
Striverdi Respimat 18 OLODATEROL HYDROCHLORIDE Boehringer Ingelheim July 2014
43
Tracleer 18 BOSENTAN Actelion November 2001
44
Tudorza Pressair 18 ACLIDINIUM BROMIDE Forest Laboratories July 2012
45
Xolair 18 OMALIZUMAB Genentech June 2003
46
Xopenex 18 LEVALBUTEROL HYDROCHLORIDE Sepracor February 2002
47
Zemaira 18 Aventis Behring July 2003

Search Clinical Trials , NIH Clinical Center for Myeloproliferative Disorder, Chronic, with Eosinophilia

Genetic Tests for Myeloproliferative Disorder, Chronic, with Eosinophilia

Genetic tests related to Myeloproliferative Disorder, Chronic, with Eosinophilia:

# Genetic test Affiliating Genes
1 Malignant Eosinophil Proliferation 29 PDGFRB

Anatomical Context for Myeloproliferative Disorder, Chronic, with Eosinophilia

MalaCards organs/tissues related to Myeloproliferative Disorder, Chronic, with Eosinophilia:

41
Bone, T Cells, Bone Marrow, Myeloid, Liver, Lung, Prostate

Publications for Myeloproliferative Disorder, Chronic, with Eosinophilia

Articles related to Myeloproliferative Disorder, Chronic, with Eosinophilia:

# Title Authors Year
1
Myeloproliferative disorder with eosinophilia and ETV6-ABL gene rearrangement: efficacy of second-generation tyrosine kinase inhibitors. ( 19394693 )
2009
2
Complete haematological and cytogenetic response to interferon alpha-2a of a myeloproliferative disorder with eosinophilia associated with a unique t(4;7) aberration. ( 10741923 )
2000
3
Cytogenetic response induced by interferon alpha in the myeloproliferative disorder with eosinophilia, T cell lymphoma and the chromosomal translocation t(8;13)(p11;q12) ( 9639434 )
1998
4
A myeloproliferative disorder with eosinophilia associated with a unique translocation (3;5). ( 8943895 )
1996

Variations for Myeloproliferative Disorder, Chronic, with Eosinophilia

Expression for Myeloproliferative Disorder, Chronic, with Eosinophilia

Search GEO for disease gene expression data for Myeloproliferative Disorder, Chronic, with Eosinophilia.

Pathways for Myeloproliferative Disorder, Chronic, with Eosinophilia

GO Terms for Myeloproliferative Disorder, Chronic, with Eosinophilia

Sources for Myeloproliferative Disorder, Chronic, with Eosinophilia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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