MCID: MYL067
MIFTS: 27

Myeloproliferative Disorder, Chronic, with Eosinophilia

Categories: Blood diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Myeloproliferative Disorder, Chronic, with Eosinophilia

MalaCards integrated aliases for Myeloproliferative Disorder, Chronic, with Eosinophilia:

Name: Myeloproliferative Disorder, Chronic, with Eosinophilia 57 40 73
Myeloproliferative Disorder with Eosinophilia 57 13
Mpe 57 75
Myeloproliferative Disorder Chronic with Eosinophilia 75
Chronic Myeloproliferative Disease, Unclassifiable 59
Undifferentiated Myeloproliferative Disease 59
Myeloproliferative Neoplasm, Unclassifiable 73
Eosinophils, Malignant Proliferation of 57
Malignant Proliferation of Eosinophils 75
Malignant Eosinophil Proliferation 29
Mpe; Emp 57
Cmpd-U 59
Emp 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant (12p13)


HPO:

32
myeloproliferative disorder, chronic, with eosinophilia:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 131440
Orphanet 59 ORPHA86830
ICD10 via Orphanet 34 D47.1
MedGen 42 C1851585
SNOMED-CT via HPO 69 263681008 414794006 425333006

Summaries for Myeloproliferative Disorder, Chronic, with Eosinophilia

UniProtKB/Swiss-Prot : 75 Myeloproliferative disorder chronic with eosinophilia: A hematologic disorder characterized by malignant eosinophils proliferation.

MalaCards based summary : Myeloproliferative Disorder, Chronic, with Eosinophilia, also known as myeloproliferative disorder with eosinophilia, is related to myeloproliferative neoplasm and pdgfrb-associated chronic eosinophilic leukemia. An important gene associated with Myeloproliferative Disorder, Chronic, with Eosinophilia is PDGFRB (Platelet Derived Growth Factor Receptor Beta). Affiliated tissues include t cells, and related phenotypes are eosinophilia and myeloproliferative disorder

Description from OMIM: 131440

Related Diseases for Myeloproliferative Disorder, Chronic, with Eosinophilia

Diseases related to Myeloproliferative Disorder, Chronic, with Eosinophilia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)
# Related Disease Score Top Affiliating Genes
1 myeloproliferative neoplasm 11.3
2 pdgfrb-associated chronic eosinophilic leukemia 11.2
3 extramedullary plasmacytoma 10.2
4 plasmacytoma 10.2
5 endotheliitis 10.1
6 lung cancer susceptibility 3 9.9
7 hemopericardium 9.9
8 pericardial effusion 9.9
9 adenocarcinoma 9.9
10 prostate cancer 9.9
11 prostatitis 9.9
12 mediastinitis 9.9
13 lymphoma 9.8
14 primary hypereosinophilic syndrome 9.4 ETV6 PDGFRB
15 myofibroma 9.4 ETV6 PDGFRB
16 chronic myelomonocytic leukemia 9.4 ETV6 PDGFRB
17 bone marrow cancer 9.3 ETV6 PDGFRB
18 leukemia, chronic myeloid 9.2 ETV6 PDGFRB
19 hematologic cancer 9.1 ETV6 PDGFRB
20 myelodysplastic syndrome 8.9 ETV6 PDGFRB

Graphical network of the top 20 diseases related to Myeloproliferative Disorder, Chronic, with Eosinophilia:



Diseases related to Myeloproliferative Disorder, Chronic, with Eosinophilia

Symptoms & Phenotypes for Myeloproliferative Disorder, Chronic, with Eosinophilia

Symptoms via clinical synopsis from OMIM:

57
Oncology:
malignant eosinophil proliferation


Clinical features from OMIM:

131440

Human phenotypes related to Myeloproliferative Disorder, Chronic, with Eosinophilia:

32
# Description HPO Frequency HPO Source Accession
1 eosinophilia 32 HP:0001880
2 myeloproliferative disorder 32 HP:0005547
3 malignant eosinophil proliferation 32 HP:0006782

GenomeRNAi Phenotypes related to Myeloproliferative Disorder, Chronic, with Eosinophilia according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.53 ETV6
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.53 TP53BP1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.53 ETV6 TP53BP1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.53 ETV6
5 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.53 ETV6
6 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.53 TP53BP1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.53 ETV6
8 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.53 TP53BP1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.53 ETV6
10 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.53 ETV6
11 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.53 ETV6
12 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.53 TP53BP1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.53 ETV6
14 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.53 TP53BP1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.53 TP53BP1

MGI Mouse Phenotypes related to Myeloproliferative Disorder, Chronic, with Eosinophilia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 8.8 ETV6 PDGFRB TP53BP1

Drugs & Therapeutics for Myeloproliferative Disorder, Chronic, with Eosinophilia

Search Clinical Trials , NIH Clinical Center for Myeloproliferative Disorder, Chronic, with Eosinophilia

Genetic Tests for Myeloproliferative Disorder, Chronic, with Eosinophilia

Genetic tests related to Myeloproliferative Disorder, Chronic, with Eosinophilia:

# Genetic test Affiliating Genes
1 Malignant Eosinophil Proliferation 29 PDGFRB

Anatomical Context for Myeloproliferative Disorder, Chronic, with Eosinophilia

MalaCards organs/tissues related to Myeloproliferative Disorder, Chronic, with Eosinophilia:

41
T Cells

Publications for Myeloproliferative Disorder, Chronic, with Eosinophilia

Articles related to Myeloproliferative Disorder, Chronic, with Eosinophilia:

# Title Authors Year
1
Congenital and childhood myeloproliferative disorders with eosinophilia responsive to imatinib. ( 22488677 )
2012
2
Myeloproliferative disorder with eosinophilia and ETV6-ABL gene rearrangement: efficacy of second-generation tyrosine kinase inhibitors. ( 19394693 )
2009
3
Complete haematological and cytogenetic response to interferon alpha-2a of a myeloproliferative disorder with eosinophilia associated with a unique t(4;7) aberration. ( 10741923 )
2000
4
Cytogenetic response induced by interferon alpha in the myeloproliferative disorder with eosinophilia, T cell lymphoma and the chromosomal translocation t(8;13)(p11;q12) ( 9639434 )
1998
5
A myeloproliferative disorder with eosinophilia associated with a unique translocation (3;5). ( 8943895 )
1996

Variations for Myeloproliferative Disorder, Chronic, with Eosinophilia

Expression for Myeloproliferative Disorder, Chronic, with Eosinophilia

Search GEO for disease gene expression data for Myeloproliferative Disorder, Chronic, with Eosinophilia.

Pathways for Myeloproliferative Disorder, Chronic, with Eosinophilia

GO Terms for Myeloproliferative Disorder, Chronic, with Eosinophilia

Sources for Myeloproliferative Disorder, Chronic, with Eosinophilia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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