MCID: MYC005
MIFTS: 47

Myocardial Stunning

Categories: Cardiovascular diseases

Aliases & Classifications for Myocardial Stunning

MalaCards integrated aliases for Myocardial Stunning:

Name: Myocardial Stunning 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9767
MeSH 44 D017682
UMLS 73 C0206146

Summaries for Myocardial Stunning

MalaCards based summary : Myocardial Stunning is related to coronary artery anomaly and arteries, anomalies of, and has symptoms including polydipsia, fatigue and edema. An important gene associated with Myocardial Stunning is SLC9A1 (Solute Carrier Family 9 Member A1), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Selenium Micronutrient Network. The drugs Ranolazine and Ticagrelor have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and skin, and related phenotypes are Negative genetic interaction between BLM-/- and BLM+/+ and Reduced mammosphere formation

Wikipedia : 76 In cardiology, stunned myocardium is a state when some section of the myocardium (corresponding to area... more...

Related Diseases for Myocardial Stunning

Diseases related to Myocardial Stunning via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 coronary artery anomaly 30.3 AGTR1 EDN1 TNNI3
2 arteries, anomalies of 30.1 AGTR1 EDN1 SERPINC1 TNNI3
3 acute myocardial infarction 30.1 AGTR1 EDN1 SERPINC1 TNNI3
4 myocardial infarction 30.1 AGTR1 AGTR2 EDN1 SERPINC1 TNNI3
5 ventricular fibrillation, paroxysmal familial, 1 30.0 KCNJ5 SLC9A1
6 chronic kidney failure 29.8 AGTR1 EDN1 SOD1
7 stroke, ischemic 29.7 AGTR1 AGTR2 SERPINC1
8 ischemia 10.6
9 toxic myocarditis 10.2 SOD1 TNNI3
10 platelet aggregation, spontaneous 10.2 SERPINC1 SOD1
11 hypertrophic cardiomyopathy 10.2
12 meningitis and encephalitis 10.1 CAT SOD1
13 malignant secondary hypertension 10.1 AGTR2 EDN1
14 erysipelas 10.1 CAT SOD1
15 intermediate coronary syndrome 10.1 SERPINC1 TNNI3
16 hepatic vascular disease 10.1 EDN1 SERPINC1
17 pulmonary artery disease 10.1 SERPINC1 TNNI3
18 cardiac arrest 10.1
19 pulmonary edema 10.1
20 mitral valve insufficiency 10.1
21 hypoxia 10.1
22 cardiogenic shock 10.1
23 meningococcal infection 10.1 AGTR1 SOD1
24 angina pectoris 10.1 EDN1 SERPINC1
25 aortic coarctation 10.0 AGTR1 EDN1
26 raynaud phenomenon 10.0 AGTR1 EDN1
27 malignant hypertension 10.0 AGTR1 EDN1
28 diabetic angiopathy 10.0 CAT EDN1
29 posterior urethral valves 10.0 AGTR1 AGTR2
30 retinal ischemia 10.0 CAT SOD1
31 renal hypertension 10.0 AGTR1 EDN1
32 familial hyperaldosteronism 10.0 AGTR1 KCNJ5
33 ischemic optic neuropathy 9.9 AGTR1 EDN1 SERPINC1
34 nonarteritic anterior ischemic optic neuropathy 9.9 AGTR1 EDN1 SERPINC1
35 limb ischemia 9.9 EDN1 TNNI3
36 acute mountain sickness 9.9 AGTR1 EDN1
37 aging 9.9
38 pulmonary hypertension 9.9
39 status epilepticus 9.9
40 epilepsy 9.9
41 coronary stenosis 9.9
42 kidney disease 9.9
43 hyperthyroidism 9.9
44 andersen cardiodysrhythmic periodic paralysis 9.9 AGTR2 KCNJ5
45 renovascular hypertension 9.9 AGTR1 CAT EDN1
46 vascular disease 9.9 CAT EDN1 SERPINC1 SOD1
47 hypertension, essential 9.8 AGTR1 AGTR2 EDN1 SLC9A1
48 heart disease 9.7 AGTR1 EDN1 SERPINC1 SOD3 TNNI3
49 pre-eclampsia 9.6 AGTR1 AGTR2 CAT EDN1 SERPINC1

Graphical network of the top 20 diseases related to Myocardial Stunning:



Diseases related to Myocardial Stunning

Symptoms & Phenotypes for Myocardial Stunning

UMLS symptoms related to Myocardial Stunning:


polydipsia, fatigue, edema, cyanosis, asthenia, chills, renal colic, signs and symptoms, signs and symptoms, digestive, hot flushes, eye manifestations, oral manifestations, urological manifestations, hypertriglyceridemic waist, body temperature changes, signs and symptoms, respiratory, skin manifestations, mobility limitation, prodromal symptoms, medically unexplained symptoms

GenomeRNAi Phenotypes related to Myocardial Stunning according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between BLM-/- and BLM+/+ GR00255-A-1 9.26 EDN1 OPRD1 SOD3 TNNI3
2 Reduced mammosphere formation GR00396-S 9.02 AGTR1 KCNJ5 OPRD1 SERPINC1 SLC9A1

MGI Mouse Phenotypes related to Myocardial Stunning:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.86 AGTR1 AGTR2 EDN1 KCNJ5 SERPINC1 SLC9A1
2 homeostasis/metabolism MP:0005376 9.81 AGTR1 AGTR2 CAT EDN1 OPRD1 SERPINC1
3 mortality/aging MP:0010768 9.61 AGTR1 AGTR2 CAT EDN1 SERPINC1 SLC9A1
4 nervous system MP:0003631 9.17 AGTR1 AGTR2 EDN1 OPRD1 SERPINC1 SLC9A1

Drugs & Therapeutics for Myocardial Stunning

Drugs for Myocardial Stunning (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 80)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranolazine Approved, Investigational Phase 4 142387-99-3, 95635-55-5 56959
2
Ticagrelor Approved Phase 4 274693-27-5 9871419
3
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
4
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
5
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
6 Nutmeg Approved Phase 4
7
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
8
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
9
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 44475014
10
Methylcobalamin Approved, Experimental, Investigational Phase 4 13422-55-4
11
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
12
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
13
Cobalamin Experimental Phase 4 13408-78-1 6438156
14 Simendan Investigational Phase 4 131741-08-7
15 Sodium Channel Blockers Phase 4
16 Diuretics, Potassium Sparing Phase 4
17 Sympatholytics Phase 4
18 Calcium, Dietary Phase 4,Not Applicable
19 Anti-Arrhythmia Agents Phase 4
20 Purinergic P2 Receptor Antagonists Phase 4
21 Antipyretics Phase 4
22 Atorvastatin Calcium Phase 4 134523-03-8
23 Adrenergic beta-1 Receptor Antagonists Phase 4
24 Mace Phase 4
25 Peripheral Nervous System Agents Phase 4,Not Applicable
26 Cyclooxygenase Inhibitors Phase 4
27 Adrenergic Antagonists Phase 4
28 Antihypertensive Agents Phase 4,Not Applicable
29 Anti-Inflammatory Agents, Non-Steroidal Phase 4
30 Lipid Regulating Agents Phase 4
31 Analgesics, Non-Narcotic Phase 4
32 Antirheumatic Agents Phase 4
33 Platelet Aggregation Inhibitors Phase 4
34 calcium channel blockers Phase 4
35 Antimetabolites Phase 4
36 Rosuvastatin Calcium Phase 4 147098-20-2
37 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
38 Adrenergic beta-Antagonists Phase 4
39 Hypolipidemic Agents Phase 4
40 Neurotransmitter Agents Phase 4
41 Anti-Inflammatory Agents Phase 4,Not Applicable
42 Autonomic Agents Phase 4,Not Applicable
43 Fibrinolytic Agents Phase 4
44 Anticholesteremic Agents Phase 4
45 Adrenergic Agents Phase 4
46 Purinergic P2Y Receptor Antagonists Phase 4
47 Chlorhexidine gluconate Phase 4
48 Analgesics Phase 4
49 Hypoglycemic Agents Phase 4,Not Applicable
50 Protective Agents Phase 4

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Ranolazine a Potential New Therapeutic Application Unknown status NCT02687269 Phase 4 Ranolazine;Placebo
2 The Success of Opening Single CTO Lesions to Improve Myocardial Viability Study (SOS-comedy) Unknown status NCT02767401 Phase 4 aspirin, clopidogrel, ticagrelor, atorvastatin, rosuvastatin, betaloc
3 The Success of Opening Concurrent Chronic Total Occlusion leSion to Improve Cardiac Function Trial in Patients With Multi-vessel Disease Enrolling by invitation NCT03372785 Phase 4 aspirin, betaloc, atorvastatin, rosuvastatin, clopidogrel, ticagrelor
4 Intracoronary Administration of Levosimendan in Cardiac Surgery Patients Suspended NCT01500785 Phase 4 levosimendan;Vitamin B 12
5 Serial Echocardiography After Subarachnoid Hemorrhage Unknown status NCT00123695
6 Clinical Study of Liraglutide in Improving Cardiac Function for Patients With Ischemic Cardiomyopathy Unknown status NCT02930265 Not Applicable Liraglutide
7 Myocardial Stunning During Hemodialysis: Role of Dialyste Calcium Concentration Completed NCT02545426 Not Applicable
8 Cardiac Sympathetic Activity in Patients With the Apical Ballooning Syndrome Completed NCT00586183 Not Applicable
9 Evaluation of Myocardial Viability by Means of Low-dose Dobutamine Gated SPECT (the DOGS Study) Completed NCT00213746
10 Exercise-induced Changes in Cardiac Function & Morphology Completed NCT01179802 Not Applicable
11 Analysis of Heart Muscle Function Following Exercise in Patients With Heart Disease Completed NCT00001528
12 Adjusting Fluid Removal Based on Blood Volume in Hemodialysis: A Randomized Study Completed NCT01988181 Not Applicable
13 Immunomodulatory Biomimetic Device to Treat Myocardial Stunning in End-stage Renal Disease Patients Recruiting NCT03539861 Not Applicable
14 Trial of Dialysate Sodium in Chronic Hospitalized Hemodialysis Patients Recruiting NCT02145260 Not Applicable Lower dialysate sodium (138 mmol/L; using Renasol hemodialysis concentrate);Higher dialysate sodium (142 mmol/L; using Renasol hemodialysis concentrate)
15 The Bern Heart and Brain Interaction Study - Interaction Between Brain and Heart in Acute Ischemic Stroke Recruiting NCT03720522
16 Risk Assessment by Cardiovascular Biomarkers in Chronic Dialysis Patients Active, not recruiting NCT02207153
17 Rate of Left Ventricular Systolic Function's Recuperation After Cardiac Surgery With Extracorporeal Circulation. Not yet recruiting NCT02770183
18 EUROpean Intracoronary Cooling Evaluation in Patients With ST-elevation Myocardial Infarction. Not yet recruiting NCT03447834 Not Applicable
19 Steroid-induced Reduction of Surgical Stress Study Withdrawn NCT00807521 Not Applicable Dexamethasone;Placebo

Search NIH Clinical Center for Myocardial Stunning

Cochrane evidence based reviews: myocardial stunning

Genetic Tests for Myocardial Stunning

Anatomical Context for Myocardial Stunning

MalaCards organs/tissues related to Myocardial Stunning:

41
Heart, Liver, Skin, Bone, Eye, Neutrophil, Kidney

Publications for Myocardial Stunning

Articles related to Myocardial Stunning:

(show top 50) (show all 440)
# Title Authors Year
1
Better characterization of dipyridamole-induced myocardial stunning by systolic wall thickening. A gated perfusion SPECT study. ( 29951894 )
2018
2
Takotsubo syndrome or myocardial stunning due to spasm of a non-obstructive left anterior descending coronary artery? ( 29923102 )
2018
3
Myocardial stunning-induced left ventricular dyssynchrony on gated single-photon emission computed tomography myocardial perfusion imaging. ( 29794947 )
2018
4
Three-vessel myocardial bridging: A possible cause of myocardial stunning. ( 30031629 )
2018
5
Myocardial Stunning After Electrocution With Complete Reversibility Within 24 Hours: Role of Repeat Transthoracic Echocardiograms in Potential Cardiac Transplant Donors. ( 30116458 )
2018
6
Editorial commentary: Interpreting and dealing with myocardial stunning. ( 29221767 )
2017
7
Myocardial stunning by gated SPECT: An old tool reinvented in a stunning turn. ( 29139036 )
2017
8
Additional value of systolic wall thickening in myocardial stunning evaluated by stress-rest gated perfusion SPECT. ( 29119373 )
2017
9
Myocardial stunning occurs during intermittent haemodialysis for acute kidney injury. ( 28352974 )
2017
10
Current interpretation of myocardial stunning. ( 29221768 )
2017
11
Citric Acid Cycle Metabolites Predict the Severity of Myocardial Stunning and Mortality in Newborn Pigs. ( 27741040 )
2016
12
Doppler echocardiographic myocardial stunning index predicts recovery of left ventricular systolic function after primary percutaneous coronary intervention. ( 27543440 )
2016
13
Parafascicular nucleus-heart neural crosstalk: Implications for seizure-induced myocardial stunning. ( 27539366 )
2016
14
Pentobarbital-Induced Myocardial Stunning in Status Epilepticus Requiring Extracorporeal Membrane Oxygenation: A Case Report and Literature Review. ( 27529037 )
2016
15
Post-ischemic myocardial stunning was the starting point of takotsubo syndrome: Restitution is justified after falling down on. ( 26163910 )
2015
16
Hemodialysis-Induced Myocardial Stunning: A Review. ( 26290919 )
2015
17
Acute intraoperative neurogenic myocardial stunning during intracranial endoscopic fenestration and shunt revision in a pediatric patient. ( 26314948 )
2015
18
Ivabradine reduces myocardial stunning in patients with exercise-inducible ischaemia. ( 26419678 )
2015
19
Prevention of myocardial stunning during percutaneous coronary interventions: novel insights from pre-treatment with glucagon-like peptide-1. ( 25700753 )
2015
20
Murine Isolated Heart Model of Myocardial Stunning Associated with Cardioplegic Arrest. ( 26275089 )
2015
21
Reply to the letter "Post-ischemic myocardial stunning was the starting point of takotsubo syndrome: Restitution is justified after falling down on". ( 26285184 )
2015
22
CASE 0-2015 Problem-Solving in Transcatheter Aortic Valve Replacement: Cardiovascular Collapse, Myocardial Stunning, and Mitral Regurgitation. ( 26119409 )
2015
23
Rare giant T-wave inversions associated with myocardial stunning: report of 2 cases. ( 25068953 )
2014
24
Myocardial stunning after resuscitation from cardiac arrest following spinal anaesthesia. ( 24963188 )
2014
25
Isolated Pulmonary Edema without Myocardial Stunning in Brainstem Strokes. ( 26322335 )
2014
26
Seizure-Induced Myocardial Stunning: A Possible Cardiac Link to Sudden Unexpected Death In Epilepsy (SUDEP). ( 25305671 )
2014
27
Clinical characteristics of myocardial stunning in acute stroke. ( 25022725 )
2014
28
Cardiomyocyte-specific overexpression of an active form of Rac predisposes the heart to increased myocardial stunning and ischemia-reperfusion injury. ( 23161879 )
2013
29
CMR imaging for the evaluation of myocardial stunning after acute myocardial infarction: a meta-analysis of prospective trials. ( 23575990 )
2013
30
Takotsubo and Takotsubo-like syndrome: a common neurogenic myocardial stunning pathway? ( 23058349 )
2013
31
Hot shot induction and reperfusion with a specific blocker of the es-ENT1 nucleoside transporter before and after hypothermic cardioplegia abolishes myocardial stunning in acutely ischemic hearts despite metabolic derangement: hot shot drug delivery before hypothermic cardioplegia. ( 23422047 )
2013
32
Reversible T-Wave Inversions and Neurogenic Myocardial Stunning in a Patient with Recurrent Stress-Induced Cardiomyopathy. ( 24147830 )
2013
33
N-terminal Pro-B-type natriuretic peptide and its correlation to haemodialysis-induced myocardial stunning. ( 23880872 )
2013
34
Spontaneous coronary artery dissection triggered post-ischemic myocardial stunning and takotsubo syndrome: two different names for the same condition. ( 23273747 )
2013
35
Myocardial bridging, apical ballooning syndrome and myocardial stunning: shall we connect the dots? ( 23647592 )
2013
36
Milrinone and levosimendan administered after reperfusion improve myocardial stunning in swine. ( 22994851 )
2013
37
High-dose erythropoietin during cardiac resuscitation lessens postresuscitation myocardial stunning in swine. ( 23806450 )
2013
38
Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine. ( 22263852 )
2012
39
Huge negative T waves reaching a depth of 36 mm below the isoelectric line on ECG associated with myocardial stunning. ( 22126257 )
2012
40
Stress cardiomyopathy: a syndrome of catecholamine-mediated myocardial stunning? ( 22297544 )
2012
41
Troponin T for the detection of dialysis-induced myocardial stunning in hemodialysis patients. ( 22822013 )
2012
42
Nitric oxide has no obligatory role in isoflurane late preconditioning against myocardial stunning. ( 23044225 )
2012
43
Pathophysiology and pathogenesis of post-resuscitation myocardial stunning. ( 21584712 )
2012
44
Postischemic myocardial stunning is superior to transient ischemic dilation for detecting multivessel coronary artery disease. ( 22185710 )
2012
45
Isoflurane late preconditioning against myocardial stunning is associated with enhanced antioxidant defenses. ( 22103751 )
2012
46
Myocardial Stunning with Hemodialysis: Clinical Challenges of the Cardiorenal Patient. ( 22851961 )
2012
47
Comparative assessment of rest and post-stress left ventricular volumes and left ventricular ejection fraction on gated myocardial perfusion imaging (MPI) and echocardiography in patients with transient ischaemic dilation on adenosine MPI: myocardial stunning or subendocardial hypoperfusion? ( 22565241 )
2012
48
Non-invasive ventilation for severe TRALI and myocardial stunning: report and literature review. ( 22869453 )
2012
49
Early detection of myocardial stunning using low-dose dobutamine magnetic resonance imaging. ( 21402349 )
2011
50
Complex I syndrome in myocardial stunning and the effect of adenosine. ( 21723387 )
2011

Variations for Myocardial Stunning

Expression for Myocardial Stunning

Search GEO for disease gene expression data for Myocardial Stunning.

Pathways for Myocardial Stunning

GO Terms for Myocardial Stunning

Cellular components related to Myocardial Stunning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.63 AGTR2 CAT EDN1 SERPINC1 SOD1 SOD3
2 plasma membrane GO:0005886 9.56 AGTR1 AGTR2 CAT KCNJ5 OPRD1 SERPINC1
3 T-tubule GO:0030315 8.62 KCNJ5 SLC9A1

Biological processes related to Myocardial Stunning according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.78 CAT EDN1 SOD3
2 response to oxidative stress GO:0006979 9.73 CAT SOD1 SOD3
3 cellular response to hypoxia GO:0071456 9.7 EDN1 OPRD1 SLC9A1
4 response to activity GO:0014823 9.63 CAT EDN1
5 positive regulation of nitric oxide biosynthetic process GO:0045429 9.63 AGTR2 EDN1
6 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway GO:0051482 9.62 AGTR1 EDN1
7 regulation of mitochondrial membrane potential GO:0051881 9.62 OPRD1 SOD1
8 positive regulation of cardiac muscle hypertrophy GO:0010613 9.61 EDN1 SLC9A1
9 regulation of vasoconstriction GO:0019229 9.6 AGTR1 EDN1
10 superoxide metabolic process GO:0006801 9.59 SOD1 SOD3
11 regulation of pH GO:0006885 9.58 EDN1 SLC9A1
12 cellular sodium ion homeostasis GO:0006883 9.58 AGTR2 SLC9A1
13 response to copper ion GO:0046688 9.57 SOD1 SOD3
14 response to muscle stretch GO:0035994 9.55 EDN1 SLC9A1
15 heart contraction GO:0060047 9.54 SOD1 TNNI3
16 cellular response to oxidative stress GO:0034599 9.54 CAT SOD1 SOD3
17 positive regulation of renal sodium excretion GO:0035815 9.51 AGTR2 EDN1
18 regulation of blood vessel diameter GO:0097746 9.49 AGTR1 AGTR2
19 removal of superoxide radicals GO:0019430 9.48 SOD1 SOD3
20 superoxide anion generation GO:0042554 9.46 EDN1 SOD1
21 response to reactive oxygen species GO:0000302 9.43 CAT SOD1
22 regulation of blood pressure GO:0008217 9.43 AGTR2 EDN1 SOD1
23 angiotensin-activated signaling pathway GO:0038166 9.4 AGTR1 AGTR2
24 regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 9.32 SLC9A1 TNNI3
25 response to ozone GO:0010193 9.16 CAT EDN1
26 renin-angiotensin regulation of aldosterone production GO:0002018 8.96 AGTR1 AGTR2
27 regulation of sensory perception of pain GO:0051930 8.8 EDN1 OPRD1 SLC9A1

Molecular functions related to Myocardial Stunning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein phosphatase 2B binding GO:0030346 9.32 SLC9A1 SOD1
2 superoxide dismutase activity GO:0004784 9.26 SOD1 SOD3
3 superoxide dismutase copper chaperone activity GO:0016532 9.16 SOD1 SOD3
4 angiotensin type II receptor activity GO:0004945 8.96 AGTR1 AGTR2
5 antioxidant activity GO:0016209 8.8 CAT SOD1 SOD3

Sources for Myocardial Stunning

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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