MCID: MYC008
MIFTS: 59

Myocarditis

Categories: Cardiovascular diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Myocarditis

Summaries for Myocarditis

NIH Rare Diseases : 53 Myocarditis is a condition that is characterized by inflammation of the heart muscle (myocardium). Some affected people have no noticeable symptoms of the condition. When present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. Myocarditis can be caused by a variety of factors including infections (viral, bacterial, parasitic, and fungal), allergic reactions to certain medications, and exposure to certain chemicals. It can also be associated with other inflammatory conditions such as lupus, Wegener's granulomatosis, giant cell arteritis and Takayasu's arteritis. Most cases occur sporadically in people with no family history of the condition. Treatment aims to address the underlying cause of the condition. Medications and rarely, a heart transplant may be needed if the heart muscle becomes weak.

MalaCards based summary : Myocarditis, also known as myocardial inflammation, is related to giant cell myocarditis and drug reaction with eosinophilia and systemic symptoms. An important gene associated with Myocarditis is MYH6 (Myosin Heavy Chain 6), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Infliximab and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and monocytes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 An extrinsic cardiomyopathy that is characterized as an inflammation of the heart muscle.

Wikipedia : 76 Myocarditis, also known as inflammatory cardiomyopathy, is inflammation of the heart muscle. Symptoms... more...

Related Diseases for Myocarditis

Diseases in the Myocarditis family:

Acute Myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 408)
# Related Disease Score Top Affiliating Genes
1 giant cell myocarditis 34.1 HLA-B MB
2 drug reaction with eosinophilia and systemic symptoms 32.4 HLA-B TNF
3 chagas disease 32.0 NOS2 NPPB TNF
4 cardiogenic shock 30.5 NPPB TNF
5 myocardial infarction 30.3 CD40LG ICAM1 MB NPPB TNF
6 systemic lupus erythematosus 30.2 CD40 CD40LG CD86 HLA-DQB1 ICAM1 TNF
7 vasculitis 30.2 CD40LG HLA-B ICAM1 TNF
8 atrial standstill 1 30.1 DMD DSP MYH6 NPPB
9 pulmonary edema 30.0 ICAM1 NPPB TNF
10 autoimmune disease 29.9 CD40 CD40LG HLA-B HLA-DQB1 TNF
11 dilated cardiomyopathy 29.9 CXADR DAG1 DMD DSP HLA-DQB1 MB
12 rheumatic disease 29.9 CD40LG HLA-B TNF
13 heart disease 29.7 DSP ICAM1 MYH6 NPPB TNF
14 malaria 29.7 CD40 CD40LG CD55 HLA-B ICAM1 NOS2
15 erythema multiforme 29.6 DSP ICAM1 TNF
16 common variable immunodeficiency 29.5 CD40 CD40LG CD86 TNF
17 dermatitis, atopic 29.5 CD40 CD86 ICAM1 TNF
18 rubella 29.5 CD40LG HLA-B HLA-DQB1 TNF
19 multiple sclerosis 29.5 CD40 CD86 HLA-DQB1 ICAM1 NOS2 TNF
20 arteries, anomalies of 29.4 ICAM1 MB NPPB TNF
21 sarcoidosis 1 29.4 ICAM1 IL12RB1 TNF
22 inflammatory bowel disease 29.1 CD40 HLA-B HLA-DQB1 ICAM1 NOS2 TNF
23 rheumatoid arthritis 29.1 CD40LG CD86 HLA-B HLA-DQB1 ICAM1 ITGB2
24 autoimmune myocarditis 12.4
25 acute myocarditis 12.4
26 rheumatic myocarditis 12.4
27 fiedler's myocarditis 12.4
28 interstitial myocarditis 12.2
29 toxic myocarditis 12.2
30 septic myocarditis 12.2
31 infectious myocarditis 12.1
32 post-infectious myocarditis 12.0
33 diphtheria 11.5
34 trichinosis 11.5
35 odontoma-dysphagia syndrome 11.0
36 spondylometaphyseal dysplasia, sedaghatian type 11.0
37 rheumatic fever-related antigen 10.6
38 influenza 10.4
39 atrioventricular block 10.3
40 myositis 10.3
41 pericarditis 10.3
42 light fixation seizure syndrome 10.3 CD40 CD40LG
43 acute myocardial infarction 10.3
44 annular erythema 10.2 ICAM1 ITGB2
45 acute hemorrhagic conjunctivitis 10.2 CD55 ICAM1
46 immunodeficiency with hyper-igm, type 4 10.2 CD40 CD40LG
47 penicilliosis 10.2 CD40 CD86 TNF
48 microscopic polyangiitis 10.2 HLA-B TNF
49 lupus erythematosus 10.2
50 sulfamethoxazole allergy 10.2 CD40 CD40LG CD86

Comorbidity relations with Myocarditis via Phenotypic Disease Network (PDN):


Acute Cystitis Chronic Myocardial Ischemia
Familial Atrial Fibrillation Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Mitral Valve Disease

Graphical network of the top 20 diseases related to Myocarditis:



Diseases related to Myocarditis

Symptoms & Phenotypes for Myocarditis

GenomeRNAi Phenotypes related to Myocarditis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.44 CD40LG DAG1 HLA-DQB1 ICAM1 NOS2 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.44 CD40 CD40LG DAG1 HLA-DQB1 ICAM1 NOS2

MGI Mouse Phenotypes related to Myocarditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.27 CD40LG CD86 CXADR DAG1 DMD DSP
2 cardiovascular system MP:0005385 10.26 CD40LG CXADR DAG1 DMD DSP HLA-DQB1
3 hematopoietic system MP:0005397 10.18 CD40 CD40LG CD55 CD86 CXADR DMD
4 homeostasis/metabolism MP:0005376 10.17 CD40 CD40LG CD86 CXADR DAG1 DMD
5 immune system MP:0005387 10.07 CD40 CD40LG CD55 CD86 CXADR DMD
6 endocrine/exocrine gland MP:0005379 10.06 CD40 CD40LG CD86 CXADR DMD HLA-DQB1
7 digestive/alimentary MP:0005381 9.98 CXADR DMD DSP HLA-DQB1 ICAM1 NOS2
8 mortality/aging MP:0010768 9.97 CD40LG CXADR DAG1 DMD DSP HLA-DQB1
9 muscle MP:0005369 9.7 CD86 CXADR DAG1 DMD DSP HLA-DQB1
10 respiratory system MP:0005388 9.17 CXADR DMD HLA-DQB1 MB MYH6 NOS2

Drugs & Therapeutics for Myocarditis

Drugs for Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 145)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 4 170277-31-3
2
Etanercept Approved, Investigational Phase 4 185243-69-0
3
Methotrexate Approved Phase 4 59-05-2, 1959-05-2 126941
4
Certolizumab pegol Approved Phase 4 428863-50-7
5
Adalimumab Approved Phase 4 331731-18-1 16219006
6
Abatacept Approved Phase 4 332348-12-6 10237
7 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Not Applicable
8 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
9 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
10 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
11
Azathioprine Approved Phase 3 446-86-6 2265
12
Prednisone Approved, Vet_approved Phase 3,Phase 2 53-03-2 5865
13
Zanamivir Approved, Investigational Phase 3 139110-80-8 60855
14
Pembrolizumab Approved Phase 3 1374853-91-4
15
Epirubicin Approved Phase 3,Phase 2 56420-45-2 41867
16
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
17
Cyclophosphamide Approved, Investigational Phase 3 6055-19-2, 50-18-0 2907
18
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
19
Carboplatin Approved Phase 3 41575-94-4 10339178 38904 498142
20
Bevacizumab Approved, Investigational Phase 3 216974-75-3
21
Cisplatin Approved Phase 3 15663-27-1 2767 441203 84093
22
Epinephrine Approved, Vet_approved Phase 3 51-43-4 5816
23
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1 50-02-2 5743
24
Racepinephrine Approved Phase 3 329-65-7 838
25
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 1 1177-87-3
26
Colchicine Approved Phase 3,Phase 2 64-86-8 6167 2833
27
Doxil Approved June 1999 Phase 3 31703
28 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1,Not Applicable
29 glucocorticoids Phase 3,Phase 2,Phase 1,Not Applicable
30 Antimetabolites Phase 3,Not Applicable
31 Hormone Antagonists Phase 3,Phase 2,Phase 1,Not Applicable
32 Hormones Phase 3,Phase 2,Phase 1,Not Applicable
33 Antimetabolites, Antineoplastic Phase 3
34 Antineoplastic Agents, Hormonal Phase 3,Phase 2,Phase 1,Not Applicable
35 Parenteral Nutrition Solutions Phase 2, Phase 3
36 Hematinics Phase 2, Phase 3
37 Pharmaceutical Solutions Phase 2, Phase 3,Phase 3,Phase 1
38 Ferrosoferric Oxide Phase 2, Phase 3
39 Cyclosporins Phase 3,Phase 2,Not Applicable
40 Vaccines Phase 3
41 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Not Applicable
42 Antiviral Agents Phase 3,Phase 2,Not Applicable
43 Shiga Toxins Phase 3
44 Antibodies Phase 3,Phase 2,Phase 1,Not Applicable
45 Immunoglobulins Phase 3,Phase 2,Phase 1,Not Applicable
46 Autonomic Agents Phase 3,Phase 2,Phase 1,Not Applicable
47 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1,Not Applicable
48 Antiemetics Phase 3,Phase 2,Phase 1,Not Applicable
49 HIV Protease Inhibitors Phase 3,Phase 1
50
protease inhibitors Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 104)
# Name Status NCT ID Phase Drugs
1 RHYTHM (Formerly Escape II Myocardium) Recruiting NCT01548768 Phase 4 TNF inhibitors;DMARDs
2 Effects of Abatacept on Myocarditis in Rheumatoid Arthritis Not yet recruiting NCT03619876 Phase 4 Abatacept;Adalimumab
3 Effects of SGLT-2 Inhibition on Myocardial Fibrosis and Inflammation as Assessed by Cardiac MRI in Patients With DM2 Not yet recruiting NCT03782259 Phase 4 dapagliflozin
4 CZECH-ICIT (CZECH Inflammatory Cardiomyopathy Immunosuppression Trial) Unknown status NCT01877746 Phase 3 Combination of prednisone and azathioprine;Combination of prednisone and azathioprine
5 DEtection of Cellular Inflammation With FERumoxytol in the HEART Completed NCT02319278 Phase 2, Phase 3 Ferumoxytol
6 Letermovir (MK-8228) Versus Placebo in the Prevention of Clinically-Significant Cytomegalovirus (CMV) Infection in Adult, CMV-Seropositive Allogeneic Hematopoietic Stem Cell Transplant Recipients (MK-8228-001) Completed NCT02137772 Phase 3 Letermovir;Placebo
7 Study of a Novel Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 14 Years in Asia Completed NCT01373281 Phase 3
8 A Study of Intravenous Zanamivir in the Treatment of Hospitalized Patients With Influenza Infection Completed NCT01527110 Phase 3 Intravenous (IV) zanamivir
9 A Study to Evaluate the Efficacy of GSK Biologicals' Influenza Vaccine in Children Completed NCT01218308 Phase 3
10 Eculizumab in Shiga-toxin Related Hemolytic and Uremic Syndrome Pediatric Patients - ECULISHU Completed NCT02205541 Phase 3 Eculizumab;Placebo
11 Anakinra Versus Placebo for the Treatment of Acute MyocarditIS Recruiting NCT03018834 Phase 2, Phase 3 ANAKINRA 100 mg/daily subcutaneously;Placebo
12 Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587) Recruiting NCT03486873 Phase 3 Standard of Care (SOC)
13 Study of Pembrolizumab (MK-3475) Versus Placebo in Combination With Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer (MK-3475-756/KEYNOTE-756) Recruiting NCT03725059 Phase 3 Placebo (P);Paclitaxel (X);Doxorubicin hydrochloride (A);Epirubicin (E);Cyclophosphamide (C);Endocrine therapy
14 Efficacy and Safety Study of First-line Treatment With Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Women With Persistent, Recurrent, or Metastatic Cervical Cancer (MK-3475-826/KEYNOTE-826) Recruiting NCT03635567 Phase 3 Paclitaxel;Cisplatin;Carboplatin;Placebo to pembrolizumab
15 Bronchiolitis in Infants Placebo Versus Dexamethasone Study Recruiting NCT03567473 Phase 3 Oral dexamethasone;Nebulized Epinephrine;Oral placebo;Nebulized normal saline
16 Myocardial Screening in Fetuses With Congenital Cytomegalovirus (CMV) Infection Not yet recruiting NCT02787382 Phase 3
17 COlchicine for the Prevention of Post Electrical Cardioversion Recurrence of AF Withdrawn NCT02582190 Phase 3 Colchicine group
18 IRon Nanoparticle Enhanced MRI in the Assessment of Myocardial infarctioN Unknown status NCT01995799 Phase 2
19 Phase II Randomized Study of Muromonab-CD3, Cyclosporine, Methylprednisolone, and Prednisone in Patients With Giant Cell Myocarditis Completed NCT00004482 Phase 2 Cyclosporine;methylprednisolone;Muromonab-CD3;prednisone
20 Myocarditis Treatment Trial Completed NCT00000524 Phase 2 cyclosporine;prednisone
21 The Effect of Intramyocardial Injection of Mesenchymal Precursor Cells on Myocardial Function in Patients Undergoing LVAD Implantation Completed NCT01442129 Phase 2
22 Optimizing Acquisition Parameters and Interpretive Methods of FDG-PET/CT With Rb-82 Completed NCT03048097 Phase 2 Fluorodeoxyglucose;Rubidium
23 Late Cardiac Evaluation of the Three Arm Belgian Trial Involving Node-positive Early Breast Cancer Patients Completed NCT01554943 Phase 2
24 A Study of MHAA4549A as Monotherapy for Acute Uncomplicated Seasonal Influenza A in Otherwise Healthy Adults Completed NCT02623322 Phase 2 MHAA4549A;Placebo
25 A Study of MHAA4549A in Combination With Oseltamivir Versus Oseltamivir in Participants With Severe Influenza A Infection Completed NCT02293863 Phase 2 MHAA4549A;Oseltamivir;Placebo
26 Outcome of Steroid Therapy for Myocardial Inflammation in Scleroderma Recruiting NCT03607071 Phase 2 Prednisolone and taper
27 PET/MRI Imaging of Cardiac Sarcoidosis Recruiting NCT03103490 Phase 2 F18 FSPG
28 Evolocumab in Acute Coronary Syndrome Recruiting NCT03515304 Phase 2 Evolocumab;Placebo
29 Regression of Fibrosis & Reversal of Diastolic Dysfunction in HFPEF Patients Treated With Allogeneic CDCs Recruiting NCT02941705 Phase 2
30 Colchicine for Patients With Chagas´ Disease( B1 Stage) Active, not recruiting NCT03704181 Phase 2 Colchicine 0.5 MG twice day for one year;Placebo Oral Tablet
31 Allogeneic Heart Stem Cells to Achieve Myocardial Regeneration Active, not recruiting NCT01458405 Phase 1, Phase 2 Placebo
32 Ipilimumab With or Without Talimogene Laherparepvec in Unresected Melanoma Active, not recruiting NCT01740297 Phase 1, Phase 2 Talimogene laherparepvec;Ipilimumab
33 Evaluation of G-CSF (Colony Stimulating Factor) in Patients With Chronic Chagas Cardiomyopathy Enrolling by invitation NCT02154269 Phase 2 Treatment with G-CSF (Granulocyte colony stimulating factor);Placebo saline
34 Non-invasive Ablation of Ventricular Tachycardia Not yet recruiting NCT03601832 Phase 1, Phase 2
35 Effect of Intramyocardial Injection of Mesenchymal Precursor Cells on Heart Function in People Receiving an LVAD Terminated NCT00927784 Phase 2 Cryoprotective media alone
36 Study to Evaluate the Efficacy and Safety of Danirixin Co-administered With Oseltamivir in the Treatment of Adults Hospitalized With Influenza Terminated NCT02927431 Phase 2 Danirixin 15 mg FBE;Danirixin 50 mg FBE;Placebo;Oseltamivir 75 mg
37 Safety and Immune Response of BMS-936559 in HIV-Infected People Taking Combination Antiretroviral Therapy Completed NCT02028403 Phase 1 BMS-936559;Placebo for BMS-936559
38 Dexamethasone, Carfilzomib, & Nivolumab With Reovirus for Relapsed/Refractory Multiple Myeloma Recruiting NCT03605719 Phase 1 Carfilzomib;Dexamethasone
39 Dilated cardiomYopathy iNtervention With Allogeneic MyocardIally-regenerative Cells (DYNAMIC) Active, not recruiting NCT02293603 Phase 1
40 International Myocarditis Registry Unknown status NCT01307735
41 Myocardial Inflammation in Systemic Lupus Erythematosus Unknown status NCT01761422
42 Oxidant-antioxidant Activity, Free Radicle Activity, Immune Response and Biomarkers in Extracorporeal Membrane Oxygenation (ECMO) Patients Unknown status NCT01089036
43 2D and Tissue Doppler Imaging Echocardiography Analysis of Left Ventricular Regional Wall Motion and Prognosis Unknown status NCT01092429
44 Transient ECG Changes in Patients With Acute Biliary Disease Unknown status NCT01706068
45 Implementation of Work in Progress (WIP) Sequences in Magnetic Resonance Imaging (MRI) Unknown status NCT01019226
46 German Centre for Cardiovascular Research Cardiomyopathy Register Unknown status NCT02187263
47 Short and Long Term Outcomes of Acute Coronary Syndrome in Patients With Non Obstructive Coronary Atherosclerosis Unknown status NCT02655718 Not Applicable
48 Cardiac Magnetic Resonance in Acute Myocarditis Completed NCT02299856
49 Magnetic Resonance Imaging in Myocarditis Completed NCT02177630
50 Risk Factors for Predictors of In-hospital Death in Acute Fulminant Myocarditis Completed NCT03219996

Search NIH Clinical Center for Myocarditis

Cochrane evidence based reviews: myocarditis

Genetic Tests for Myocarditis

Anatomical Context for Myocarditis

MalaCards organs/tissues related to Myocarditis:

41
Heart, T Cells, Monocytes, Breast, Bone, Tonsil, B Cells

Publications for Myocarditis

Articles related to Myocarditis:

(show top 50) (show all 2974)
# Title Authors Year
1
Evidence of aldosterone synthesis in human myocardium in acute myocarditis. ( 30384979 )
2019
2
Predictors, Burden, and the Impact of Arrhythmia on Patients Admitted for Acute Myocarditis. ( 30539745 )
2019
3
Imaging the itis: endocarditis, myocarditis, and pericarditis. ( 30444758 )
2019
4
Presence of antibodies to striated muscle and acetylcholine receptor in association with occurrence of myasthenia gravis with myositis and myocarditis in a patient with melanoma treated with an anti-programmed death 1 antibody. ( 30528803 )
2019
5
Concomitant myasthenia gravis, myositis, myocarditis and polyneuropathy, induced by immune-checkpoint inhibitors: A life-threatening continuum of neuromuscular and cardiac toxicity. ( 30533536 )
2019
6
Ventricular arrhythmias and myocardial inflammation: Long-term follow-up of patients with suspected myocarditis. ( 30122502 )
2019
7
Detection of influenza myocarditis using national healthcare safety network surveillance definitions accounting for fever in older adults. ( 29945685 )
2018
8
Acute Myocarditis with Infarct-like Presentation in a Pediatric Population: Role of Cardiovascular Magnetic Resonance. ( 28986648 )
2018
9
RE: Multi-Parameter CMR Approach in Acute Myocarditis to Improve Diagnosis and Prognostic Stratification. ( 29520196 )
2018
10
Acute myocarditis as a revealing clue of complete Kawasaki disease. ( 29976047 )
2018
11
Anthracycline-induced acute myocarditis and ventricular fibrillation arrest. ( 29194712 )
2018
12
Infectious myocarditis: the role of the cardiac vasculature. ( 29536322 )
2018
13
Assessment of TSPO in a Rat Experimental Autoimmune Myocarditis Model: A Comparison Study between [<sup>18</sup>F]Fluoromethyl-PBR28 and [<sup>18</sup>F]CB251. ( 29342117 )
2018
14
Acute myocarditis secondary to acute<i>Campylobacter jejuni</i>infection. ( 29436448 )
2018
15
Is the higher incidence of clozapine induced myocarditis in Australia due to awareness and monitoring? ( 29907491 )
2018
16
Treatment options in myocarditis and inflammatory cardiomyopathy : Focus on i.a8^v. immunoglobulins. ( 29947834 )
2018
17
Myocarditis following diphtheria, whole-cell pertussis, and tetanus toxoid vaccination in a young infant. ( 29922028 )
2018
18
Hypereosinophilic Syndrome Complicated by Eosinophilic Myocarditis With Dramatic Response to Steroid. ( 29581993 )
2018
19
Urinary candidate biomarkers in an experimental autoimmune myocarditis rat model. ( 29524647 )
2018
20
Acute myocarditis with thrombus near left ventricular outflow tract. ( 29457263 )
2018
21
Myocarditis: An Interleukin-1-Mediated Disease? ( 29951067 )
2018
22
CD80 Regulates Th17 Cell Differentiation in Coxsackie Virus B3-Induced Acute Myocarditis. ( 29039143 )
2018
23
Myocardial inflammation detected by cardiac MRI in Arrhythmogenic right ventricular cardiomyopathy: A paediatric case series. ( 29885824 )
2018
24
Vasoactive Intestinal Peptide Ameliorates Acute Myocarditis and Atherosclerosis by Regulating Inflammatory and Autoimmune Responses. ( 29669783 )
2018
25
A Case of dilated Cardiomyopathy with Eosinophilic Granulomatosis with Polyangiitis in which Active Myocardial Inflammation was Only Detected by Endomyocardial Biopsy. ( 29709930 )
2018
26
Incremental value of cardiovascular magnetic resonance feature tracking derived atrial and ventricular strain parameters in a comprehensive approach for the diagnosis of acute myocarditis. ( 29857857 )
2018
27
Hemoadsorption in cardiac shock with biventricular failure and giant-cell myocarditis: A case report. ( 29843541 )
2018
28
Ulinastatin Protects against CVB3-Induced Acute Viral Myocarditis through Nrf2 Activation. ( 29383542 )
2018
29
Pancreatitis and myocarditis coexistence due to infection by Coxsackie B1 and B4 viruses. ( 29375831 )
2018
30
Myocarditis in a girl with mixed connective tissue disease. ( 29624816 )
2018
31
Fulminant giant-cell myocarditis on mechanical circulatory support: Management and outcomes of a French multicentre cohort. ( 29306448 )
2018
32
Case report of severe myocarditis in an immunocompromised child with Respiratory Syncytial Virus infection. ( 29433478 )
2018
33
Electrocardiographic Predictors of Morbidity and Mortality in Patients With Acute Myocarditis: The Importance of QRS-T Angle. ( 29158065 )
2018
34
FGL2 knockdown improves heart function through regulation of TLR9 signaling in the experimental autoimmune myocarditis rats. ( 29128901 )
2018
35
MR imaging of catecholamine-mediated myocarditis complicated by left ventricular thrombus. ( 29396086 )
2018
36
Giant Cell Polymyositis and Myocarditis in a Patient With Thymoma and Myasthenia Gravis: A Postviral Autoimmune Process? ( 29850899 )
2018
37
Ferumoxytol-enhanced magnetic resonance imaging in acute myocarditis. ( 28986407 )
2018
38
<i>Astragalus mongholicus (Fisch.) Bge</i> Improves Peripheral Treg Cell Immunity Imbalance in the Children With Viral Myocarditis by Reducing the Levels of miR-146b and miR-155. ( 29977885 )
2018
39
When the heart gets the flu: Fulminant influenza B myocarditis: A case-series report and review of the literature. ( 29929152 )
2018
40
Circulating MicroRNAs: a Potential Biomarker for Cardiac Damage, Inflammatory Response, and Left Ventricular Function Recovery in Pediatric Viral Myocarditis. ( 29916103 )
2018
41
Sirolimus for Recurrent Giant Cell Myocarditis After Heart Transplantation: A Unique Therapeutic Strategy. ( 29889677 )
2018
42
A Case of Myocarditis and Near-Lethal Arrhythmia Associated With Interleukin-2 Therapy. ( 29399586 )
2018
43
Myocarditis secondary to smallpox vaccination. ( 29572367 )
2018
44
Letter by Jin-shan and Xue-bin Regarding Article, &amp;quot;Survival and Left Ventricular Function Changes in Fulminant Versus Nonfulminant Acute Myocarditis&amp;quot;. ( 29581376 )
2018
45
Giant cell myocarditis causing refractory ventricular tachycardia in a pediatric patient. ( 29636926 )
2018
46
Recurrent ventricular arrhythmia in a patient with aortitis and myocardial inflammation due to possible immunoglobulin G4-related disease. ( 29722185 )
2018
47
Response by Ammirati et al to Letter Regarding Article, &amp;quot;Survival and Left Ventricular Function Changes in Fulminant Versus Nonfulminant Acute Myocarditis&amp;quot;. ( 29581377 )
2018
48
Phaeochromocytoma found on cardiovascular magnetic resonance in a patient presenting with acute myocarditis: an unusual association. ( 29884661 )
2018
49
Myocarditis as a Form of Presentation of an Inflammatory Autoimmune Myopathy Associated With Anti-signal Recognition Particle Antibodies. ( 29970348 )
2018
50
Early use of anakinra in adult-onset Still's disease myocarditis. ( 29291663 )
2018

Variations for Myocarditis

ClinVar genetic disease variations for Myocarditis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ABCD1 NM_000033.3(ABCD1): c.1866-1G> C single nucleotide variant Likely pathogenic GRCh37 Chromosome X, 153008674: 153008674
2 ABCD1 NM_000033.3(ABCD1): c.1866-1G> C single nucleotide variant Likely pathogenic GRCh38 Chromosome X, 153743220: 153743220
3 AMER1 NM_152424.3(AMER1): c.1911_1912delGA (p.Glu637Aspfs) deletion Uncertain significance GRCh38 Chromosome X, 64191375: 64191376
4 AMER1 NM_152424.3(AMER1): c.1911_1912delGA (p.Glu637Aspfs) deletion Uncertain significance GRCh37 Chromosome X, 63411255: 63411256

Expression for Myocarditis

Search GEO for disease gene expression data for Myocarditis.

Pathways for Myocarditis

Pathways related to Myocarditis according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 CD40 CD40LG CD55 CD86 CXADR DSP
2
Show member pathways
13.39 CD40 CD40LG CD86 CXADR HLA-B HLA-DQB1
3
Show member pathways
13.22 CD40 CD40LG CD86 HLA-B HLA-DQB1 HLA-DRB4
4
Show member pathways
12.76 HLA-B HLA-DQB1 HLA-DRB4 ICAM1 TNF
5
Show member pathways
12.6 CD40 CD40LG CD86 HLA-DQB1 HLA-DRB4 IL12RB1
6
Show member pathways
12.56 CD86 HLA-DQB1 HLA-DRB4 IL12RB1 TNF
7
Show member pathways
12.46 HLA-B ICAM1 ITGB2 TNF
8
Show member pathways
12.38 DAG1 DMD DSP ITGB2
9
Show member pathways
12.36 CD40 CD40LG CD86 HLA-DQB1 HLA-DRB4
10 12.35 CD40 HLA-B HLA-DQB1 HLA-DRB4 ICAM1 ITGB2
11
Show member pathways
12.3 ICAM1 ITGB2 MYH6 NOS2
12 12.26 CD40 HLA-B HLA-DQB1 HLA-DRB4 ICAM1 TNF
13
Show member pathways
12.24 CD40 CD40LG CD55 CD86 CXADR DAG1
14 12.19 HLA-DQB1 HLA-DRB4 ITGB2 NOS2 TNF
15
Show member pathways
12.18 DAG1 DMD MYH6 TNF
16 12.1 HLA-B HLA-DQB1 HLA-DRB4 ITGB2
17
Show member pathways
12.07 CD40 CD40LG HLA-DQB1 HLA-DRB4 ITGB2 NOS2
18 12.04 CD40 CD40LG CXADR HLA-B ICAM1 ITGB2
19 12 CXADR DSP ICAM1 ITGB2
20 11.95 ICAM1 ITGB2 NOS2 TNF
21 11.86 CD55 HLA-DQB1 HLA-DRB4 TNF
22 11.85 CD40 CD40LG ICAM1 TNF
23 11.84 ITGB2 NOS2 TNF
24 11.73 ITGB2 NOS2 TNF
25 11.72 CD40 CD40LG CD86 HLA-B HLA-DQB1 HLA-DRB4
26
Show member pathways
11.71 CD40 CD40LG TNF
27 11.7 CD40 CD86 NOS2 TNF
28 11.69 CD86 HLA-DQB1 HLA-DRB4
29
Show member pathways
11.62 CD40LG ICAM1 NOS2 TNF
30 11.59 CD40 CD40LG CD86
31 11.59 CD86 HLA-DQB1 HLA-DRB4 ICAM1 ITGB2 TNF
32 11.56 HLA-DQB1 HLA-DRB4 ICAM1 ITGB2
33 11.55 CD40 CD40LG CD86
34 11.5 CD86 ICAM1 TNF
35 11.49 ICAM1 ITGB2 TNF
36 11.49 ITGB2 NOS2 TNF
37 11.41 CD40 CD40LG ICAM1 ITGB2 TNF
38 11.36 HLA-B ICAM1 NOS2
39 11.29 CD40 CD40LG CD86
40 10.89 ICAM1 TNF
41 10.56 MB NOS2

GO Terms for Myocarditis

Cellular components related to Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.81 CD40 CD40LG CD55 CD86 DMD HLA-B
2 filopodium GO:0030175 9.63 CXADR DAG1 DMD
3 ER to Golgi transport vesicle membrane GO:0012507 9.61 HLA-B HLA-DQB1 HLA-DRB4
4 ficolin-1-rich granule membrane GO:0101003 9.58 CD55 DSP ITGB2
5 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.54 HLA-B HLA-DQB1 HLA-DRB4
6 membrane raft GO:0045121 9.5 CD55 CXADR DAG1 DMD ICAM1 ITGB2
7 external side of plasma membrane GO:0009897 9.23 CD40 CD40LG CD86 DAG1 ICAM1 IL12RB1
8 plasma membrane GO:0005886 10.16 CD40 CD40LG CD55 CD86 CXADR DAG1
9 extracellular exosome GO:0070062 10.02 CD40 CD55 CD86 DAG1 DSP HLA-B

Biological processes related to Myocarditis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.97 CD40LG CD86 HLA-B HLA-DQB1 TNF
2 viral process GO:0016032 9.91 CD55 CD86 CXADR DAG1 HLA-B ICAM1
3 extracellular matrix organization GO:0030198 9.85 DAG1 ICAM1 ITGB2 TNF
4 leukocyte migration GO:0050900 9.84 CXADR ICAM1 ITGB2 TNF
5 cell-cell adhesion GO:0098609 9.8 CXADR DSP ICAM1 ITGB2
6 cellular response to lipopolysaccharide GO:0071222 9.77 CD40 CD86 ICAM1 NOS2 TNF
7 cellular response to interferon-gamma GO:0071346 9.76 ICAM1 IL12RB1 NOS2
8 tumor necrosis factor-mediated signaling pathway GO:0033209 9.73 CD40 CD40LG TNF
9 cytokine-mediated signaling pathway GO:0019221 9.73 CD86 ICAM1 IL12RB1 ITGB2 NOS2 TNF
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.72 CD40 CD40LG ICAM1 ITGB2 TNF
11 interferon-gamma-mediated signaling pathway GO:0060333 9.71 HLA-B HLA-DQB1 HLA-DRB4 ICAM1
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.69 ICAM1 ITGB2 TNF
13 leukocyte cell-cell adhesion GO:0007159 9.63 CD40LG ICAM1 ITGB2
14 regulation of immune response GO:0050776 9.63 CD40 CD40LG CXADR HLA-B ICAM1 ITGB2
15 cardiac muscle fiber development GO:0048739 9.59 CXADR MYH6
16 response to denervation involved in regulation of muscle adaptation GO:0014894 9.57 DAG1 DMD
17 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.52 ICAM1 TNF
18 cellular extravasation GO:0045123 9.48 ITGB2 TNF
19 regulation of immunoglobulin secretion GO:0051023 9.13 CD40 CD40LG TNF
20 viral entry into host cell GO:0046718 9.02 CD55 CD86 CXADR DAG1 ICAM1

Molecular functions related to Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.62 CD40 CD86 ICAM1 ITGB2
2 vinculin binding GO:0017166 9.37 DAG1 DMD
3 cell adhesion molecule binding GO:0050839 9.33 CXADR DSP ITGB2
4 dystroglycan binding GO:0002162 9.26 DAG1 DMD
5 integrin binding GO:0005178 9.26 CXADR DMD ICAM1 ITGB2
6 virus receptor activity GO:0001618 9.02 CD55 CD86 CXADR DAG1 ICAM1

Sources for Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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