MCID: MYC008
MIFTS: 58

Myocarditis

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Myocarditis

Summaries for Myocarditis

NIH Rare Diseases : 53 Myocarditis is a condition that is characterized by inflammation of the heart muscle (myocardium). Some affected people have no noticeable symptoms of the condition. When present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. Myocarditis can be caused by a variety of factors including infections (viral, bacterial, parasitic, and fungal), allergic reactions to certain medications, and exposure to certain chemicals. It can also be associated with other inflammatory conditions such as lupus, Wegener's granulomatosis, giant cell arteritis and Takayasu's arteritis. Most cases occur sporadically in people with no family history of the condition. Treatment aims to address the underlying cause of the condition. Medications and rarely, a heart transplant may be needed if the heart muscle becomes weak.

MalaCards based summary : Myocarditis, also known as myocardial inflammation, is related to giant cell myocarditis and chagas disease. An important gene associated with Myocarditis is MYH6 (Myosin Heavy Chain 6), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Infliximab and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and liver, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 An extrinsic cardiomyopathy that is characterized as an inflammation of the heart muscle.

Wikipedia : 76 Myocarditis, also known as inflammatory cardiomyopathy, is inflammation of the heart muscle. Symptoms... more...

Related Diseases for Myocarditis

Diseases in the Myocarditis family:

Acute Myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 361)
# Related Disease Score Top Affiliating Genes
1 giant cell myocarditis 34.4 HLA-B MB
2 chagas disease 31.7 NOS2 NPPB TNF
3 plasmodium vivax malaria 30.5 CD40LG ICAM1 TNF
4 neuronitis 30.4 CD40LG MB
5 vasculitis 30.3 CD40LG ICAM1 TNF
6 acquired immunodeficiency syndrome 30.0 CD40LG HLA-B TNF
7 erythema multiforme 29.9 DSP ICAM1 TNF
8 chlamydia 29.9 CD40LG NOS2 TNF
9 common variable immunodeficiency 29.9 CD40 CD40LG CD86 TNF
10 autoimmune disease 29.9 CD40 CD40LG HLA-B HLA-DQB1 TNF
11 systemic lupus erythematosus 29.8 CD40 CD40LG CD86 HLA-DQB1 ICAM1 TNF
12 rubella 29.7 CD40LG HLA-B HLA-DQB1 TNF
13 pulmonary edema 29.7 ICAM1 NPPB TNF
14 atrial standstill 1 29.7 DMD DSP MYH6 NPPB
15 myocardial infarction 29.2 CD40LG ICAM1 MB NPPB TNF
16 arteries, anomalies of 29.0 ICAM1 MB NPPB TNF
17 multiple sclerosis 28.8 CD40 CD86 HLA-DQB1 ICAM1 NOS2 TNF
18 malaria 28.8 CD40 CD40LG CD55 HLA-B ICAM1 NOS2
19 dilated cardiomyopathy 27.5 CD40LG CXADR DAG1 DMD DSP HLA-DQB1
20 autoimmune myocarditis 12.3
21 acute myocarditis 12.3
22 rheumatic myocarditis 12.3
23 fiedler's myocarditis 12.2
24 interstitial myocarditis 12.1
25 toxic myocarditis 12.1
26 septic myocarditis 12.0
27 infectious myocarditis 12.0
28 post-infectious myocarditis 11.8
29 diphtheria 11.4
30 trichinosis 11.4
31 light fixation seizure syndrome 10.9 CD40 CD40LG
32 odontoma-dysphagia syndrome 10.9
33 spondylometaphyseal dysplasia, sedaghatian type 10.9
34 heterophyiasis 10.8 CD40LG ICAM1
35 immunodeficiency with hyper-igm, type 4 10.8 CD40 CD40LG
36 annular erythema 10.8 ICAM1 ITGB2
37 trench fever 10.8 CD40LG TNF
38 encephalitozoonosis 10.8 CD40LG TNF
39 rheumatoid lung disease 10.8 CD40LG TNF
40 microscopic polyangiitis 10.8 HLA-B TNF
41 penicilliosis 10.8 CD40 CD86 TNF
42 cardiomyopathy, dilated, 1b 10.7 DAG1 DMD
43 lichen disease 10.7 CD40LG ICAM1 TNF
44 exanthema subitum 10.7 CD40 CD40LG CD86
45 cutaneous lupus erythematosus 10.7 CD40LG ICAM1 TNF
46 beryllium disease 10.7 HLA-DQB1 TNF
47 parasitic protozoa infectious disease 10.7 CD40LG ICAM1 TNF
48 guillain-barre syndrome 10.7 CD40LG HLA-DQB1 TNF
49 miller fisher syndrome 10.7 CD40LG TNF
50 borderline leprosy 10.7 CD40LG NOS2

Comorbidity relations with Myocarditis via Phenotypic Disease Network (PDN):


Acute Cystitis Chronic Myocardial Ischemia
Familial Atrial Fibrillation Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Mitral Valve Disease

Graphical network of the top 20 diseases related to Myocarditis:



Diseases related to Myocarditis

Symptoms & Phenotypes for Myocarditis

GenomeRNAi Phenotypes related to Myocarditis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.44 CD40LG DAG1 HLA-DQB1 ICAM1 NOS2 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.44 CD40 CD40LG DAG1 HLA-DQB1 ICAM1 NOS2

MGI Mouse Phenotypes related to Myocarditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.27 DAG1 CD40LG DMD CD86 DSP CXADR
2 cardiovascular system MP:0005385 10.26 DAG1 CD40LG DMD DSP CXADR HLA-DQB1
3 hematopoietic system MP:0005397 10.18 CD40 CD40LG DMD CD55 CD86 CXADR
4 homeostasis/metabolism MP:0005376 10.17 CD40 DAG1 CD40LG DMD CD86 CXADR
5 immune system MP:0005387 10.07 CD40 CD40LG DMD CD55 CD86 CXADR
6 endocrine/exocrine gland MP:0005379 10.06 CD40 CD40LG DMD CD86 CXADR HLA-DQB1
7 digestive/alimentary MP:0005381 9.98 CXADR DMD DSP HLA-DQB1 ICAM1 NOS2
8 mortality/aging MP:0010768 9.97 DAG1 CD40LG DMD DSP CXADR HLA-DQB1
9 muscle MP:0005369 9.7 DAG1 DMD CD86 DSP CXADR HLA-DQB1
10 respiratory system MP:0005388 9.17 CXADR DMD HLA-DQB1 MYH6 NOS2 TNF

Drugs & Therapeutics for Myocarditis

Drugs for Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 99)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 4 170277-31-3
2
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
3
Etanercept Approved, Investigational Phase 4 185243-69-0
4
Certolizumab pegol Approved Phase 4 428863-50-7
5
Adalimumab Approved Phase 4 331731-18-1 16219006
6 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Not Applicable
7
Azathioprine Approved Phase 3 446-86-6 2265
8
Prednisone Approved, Vet_approved Phase 3,Phase 2 53-03-2 5865
9
Zanamivir Approved, Investigational Phase 3 139110-80-8 60855
10 glucocorticoids Phase 3,Phase 2,Not Applicable
11 Ferrosoferric Oxide Phase 2, Phase 3
12 Hematinics Phase 2, Phase 3
13 Hormone Antagonists Phase 3,Phase 2,Not Applicable
14 Hormones Phase 3,Phase 2,Not Applicable
15 Parenteral Nutrition Solutions Phase 2, Phase 3
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
17 Pharmaceutical Solutions Phase 2, Phase 3,Phase 3
18 Immunosuppressive Agents Phase 3,Phase 2,Not Applicable
19 Anti-Inflammatory Agents Phase 3,Phase 2,Not Applicable
20 Antimetabolites Phase 3,Not Applicable
21 Antimetabolites, Antineoplastic Phase 3
22 Antineoplastic Agents, Hormonal Phase 3,Phase 2,Not Applicable
23 Cyclosporins Phase 3,Phase 2,Not Applicable
24 Vaccines Phase 3
25 Antibodies Phase 3,Phase 1,Phase 2,Not Applicable
26 Immunoglobulins Phase 3,Phase 1,Phase 2,Not Applicable
27 Anti-Infective Agents Phase 3,Phase 2,Not Applicable
28 Antiviral Agents Phase 3,Phase 2,Not Applicable
29 Adrenergic Agents Phase 2, Phase 3
30 Adrenergic Antagonists Phase 2, Phase 3
31 Adrenergic beta-Antagonists Phase 2, Phase 3
32 Shiga Toxins Phase 3
33 Neurotransmitter Agents Phase 2, Phase 3
34 Interleukin 1 Receptor Antagonist Protein Phase 2, Phase 3
35
Iron Approved Phase 2 7439-89-6 23925
36
Mannitol Approved, Investigational Phase 2,Not Applicable 69-65-8 453 6251
37
Miconazole Approved, Investigational, Vet_approved Phase 2,Not Applicable 22916-47-8 4189
38
Oseltamivir Approved Phase 2 204255-11-8, 196618-13-0 65028
39
Prednisolone Approved, Vet_approved Phase 2,Not Applicable 50-24-8 5755
40
Methylprednisolone Approved, Vet_approved Phase 2,Not Applicable 83-43-2 6741
41
Epirubicin Approved Phase 2 56420-45-2 41867
42
Lenograstim Approved, Investigational Phase 2 135968-09-1
43
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
44
Betadex Experimental Phase 2 7585-39-9 320761
45 Protective Agents Phase 2,Not Applicable
46 Prednisolone acetate Phase 2,Not Applicable
47 Muromonab-CD3 Phase 2,Not Applicable
48 Methylprednisolone acetate Phase 2,Not Applicable
49 Methylprednisolone Hemisuccinate Phase 2,Not Applicable
50 Fluorodeoxyglucose F18 Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 85)
# Name Status NCT ID Phase Drugs
1 RHYTHM (Formerly Escape II Myocardium) Recruiting NCT01548768 Phase 4 TNF inhibitors;DMARDs
2 CZECH-ICIT (CZECH Inflammatory Cardiomyopathy Immunosuppression Trial) Unknown status NCT01877746 Phase 3 Combination of prednisone and azathioprine;Combination of prednisone and azathioprine
3 DEtection of Cellular Inflammation With FERumoxytol in the HEART Completed NCT02319278 Phase 2, Phase 3 Ferumoxytol
4 Letermovir (MK-8228) Versus Placebo in the Prevention of Clinically-Significant Cytomegalovirus (CMV) Infection in Adult, CMV-Seropositive Allogeneic Hematopoietic Stem Cell Transplant Recipients (MK-8228-001) Completed NCT02137772 Phase 3 Letermovir;Placebo
5 A Study of Intravenous Zanamivir in the Treatment of Hospitalized Patients With Influenza Infection Completed NCT01527110 Phase 3 Intravenous (IV) zanamivir
6 A Study to Evaluate the Efficacy of GSK Biologicals' Influenza Vaccine in Children Completed NCT01218308 Phase 3
7 Anakinra Versus Placebo for the Treatment of Acute MyocarditIS Recruiting NCT03018834 Phase 2, Phase 3 ANAKINRA 100 mg/daily subcutaneously;Placebo
8 Eculizumab in Shiga-toxin Related Hemolytic and Uremic Syndrome Pediatric Patients - ECULISHU Recruiting NCT02205541 Phase 3 Eculizumab;Placebo
9 Myocardial Screening in Fetuses With Congenital Cytomegalovirus (CMV) Infection Not yet recruiting NCT02787382 Phase 3
10 Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587) Not yet recruiting NCT03486873 Phase 3 Standard of Care (SOC)
11 Nebulized Epinephrine and Oral Dexamethasone in Bronchiolitis Not yet recruiting NCT03567473 Phase 3 Oral dexamethasone;Nebulized Epinephrine;Oral placebo;Nebulized normal saline
12 COlchicine for the Prevention of Post Electrical Cardioversion Recurrence of AF Withdrawn NCT02582190 Phase 3 Colchicine group
13 IRon Nanoparticle Enhanced MRI in the Assessment of Myocardial infarctioN Unknown status NCT01995799 Phase 2
14 Phase II Randomized Study of Muromonab-CD3, Cyclosporine, Methylprednisolone, and Prednisone in Patients With Giant Cell Myocarditis Completed NCT00004482 Phase 2 Cyclosporine;methylprednisolone;Muromonab-CD3;prednisone
15 Myocarditis Treatment Trial Completed NCT00000524 Phase 2 cyclosporine;prednisone
16 The Effect of Intramyocardial Injection of Mesenchymal Precursor Cells on Myocardial Function in Patients Undergoing LVAD Implantation Completed NCT01442129 Phase 2
17 Optimizing Acquisition Parameters and Interpretive Methods of FDG-PET/CT With Rb-82 Completed NCT03048097 Phase 2 Fluorodeoxyglucose;Rubidium
18 Late Cardiac Evaluation of the Three Arm Belgian Trial Involving Node-positive Early Breast Cancer Patients Completed NCT01554943 Phase 2
19 A Study of MHAA4549A in Combination With Oseltamivir Versus Oseltamivir in Participants With Severe Influenza A Infection Completed NCT02293863 Phase 2 MHAA4549A;Oseltamivir;Placebo
20 PET/MRI Imaging of Cardiac Sarcoidosis Recruiting NCT03103490 Phase 2 F18 FSPG
21 Evolocumab in Acute Coronary Syndrome Recruiting NCT03515304 Phase 2 Evolocumab;Placebo
22 Regression of Fibrosis & Reversal of Diastolic Dysfunction in HFPEF Patients Treated With Allogeneic CDCs Recruiting NCT02941705 Phase 2
23 Allogeneic Heart Stem Cells to Achieve Myocardial Regeneration Active, not recruiting NCT01458405 Phase 1, Phase 2
24 Ipilimumab With or Without Talimogene Laherparepvec in Unresected Melanoma Active, not recruiting NCT01740297 Phase 1, Phase 2 Talimogene laherparepvec;Ipilimumab
25 Evaluation of G-CSF (Colony Stimulating Factor) in Patients With Chronic Chagas Cardiomyopathy Enrolling by invitation NCT02154269 Phase 2 Treatment with G-CSF (Granulocyte colony stimulating factor);Placebo saline
26 Effect of Intramyocardial Injection of Mesenchymal Precursor Cells on Heart Function in People Receiving an LVAD Terminated NCT00927784 Phase 2 Cryoprotective media alone
27 Study to Evaluate the Efficacy and Safety of Danirixin Co-administered With Oseltamivir in the Treatment of Adults Hospitalized With Influenza Terminated NCT02927431 Phase 2 Danirixin 15 mg FBE;Danirixin 50 mg FBE;Placebo;Oseltamivir 75 mg
28 Safety and Immune Response of BMS-936559 in HIV-Infected People Taking Combination Antiretroviral Therapy Completed NCT02028403 Phase 1 BMS-936559;Placebo for BMS-936559
29 Dilated cardiomYopathy iNtervention With Allogeneic MyocardIally-regenerative Cells (DYNAMIC) Active, not recruiting NCT02293603 Phase 1
30 International Myocarditis Registry Unknown status NCT01307735
31 Myocardial Inflammation in Systemic Lupus Erythematosus Unknown status NCT01761422
32 Oxidant-antioxidant Activity, Free Radicle Activity, Immune Response and Biomarkers in Extracorporeal Membrane Oxygenation (ECMO) Patients Unknown status NCT01089036
33 2D and Tissue Doppler Imaging Echocardiography Analysis of Left Ventricular Regional Wall Motion and Prognosis Unknown status NCT01092429
34 Transient ECG Changes in Patients With Acute Biliary Disease Unknown status NCT01706068
35 Implementation of Work in Progress (WIP) Sequences in Magnetic Resonance Imaging (MRI) Unknown status NCT01019226
36 German Centre for Cardiovascular Research Cardiomyopathy Register Unknown status NCT02187263
37 Cardiac Magnetic Resonance in Acute Myocarditis Completed NCT02299856
38 Magnetic Resonance Imaging in Myocarditis Completed NCT02177630
39 Risk Factors for Predictors of In-hospital Death in Acute Fulminant Myocarditis Completed NCT03219996
40 CMR Features in Patients With Suspected Myocarditis Completed NCT03470571
41 CMR in Patients With Myocarditis Completed NCT01962584
42 Study of Muromonab-CD3 and Cyclosporine in Patients With Giant Cell Myocarditis Completed NCT00027443 Not Applicable Muromonab-CD3;Cyclosporine
43 Role of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinases (TIMPs) in Children With Myocarditis Completed NCT00693134
44 Evaluation of Reporting of Immune Checkpoint Inhibitor Associated Cardio-vascular Adverse Reactions Completed NCT03387540 ICI
45 Safety Surveillance Study of ACAM2000® Vaccinia Vaccine Completed NCT00927719
46 Evaluation of Myocardial Iron Deposition in Patients of Heart Failure Using T2* MR Imaging Completed NCT02527330
47 Detection of Enterovirus RNA in Atheromatous Lesions Completed NCT00674531 Not Applicable
48 Cardiovascular Diseases in HIV-infected Patients HIV-HEART Study: 7.5 Years Follow-up Completed NCT01667068
49 Cardiovascular Diseases in HIV-infected Patients HIV-HEART Study: 5 Years Follow-up Completed NCT01196273
50 Analgesic Efficacy of Arnica Montana in Comparison With Diclofenac Sodium Following a Periodontal Surgical Procedure Completed NCT03520595 Not Applicable Arnica 200 drug 3 pills,3 times daily for 3 days;Diclofenac Sodium 50mg twice daily;Placebo pills and distilled water 3 pills,3 times daily

Search NIH Clinical Center for Myocarditis

Cochrane evidence based reviews: myocarditis

Genetic Tests for Myocarditis

Anatomical Context for Myocarditis

MalaCards organs/tissues related to Myocarditis:

41
Heart, T Cells, Liver, Monocytes, Tonsil, B Cells, Bone

Publications for Myocarditis

Articles related to Myocarditis:

(show top 50) (show all 2075)
# Title Authors Year
1
Detection of influenza myocarditis using national healthcare safety network surveillance definitions accounting for fever in older adults. ( 29945685 )
2018
2
Acute Myocarditis with Infarct-like Presentation in a Pediatric Population: Role of Cardiovascular Magnetic Resonance. ( 28986648 )
2018
3
RE: Multi-Parameter CMR Approach in Acute Myocarditis to Improve Diagnosis and Prognostic Stratification. ( 29520196 )
2018
4
Acute myocarditis as a revealing clue of complete Kawasaki disease. ( 29976047 )
2018
5
Anthracycline-induced acute myocarditis and ventricular fibrillation arrest. ( 29194712 )
2018
6
Infectious myocarditis: the role of the cardiac vasculature. ( 29536322 )
2018
7
Assessment of TSPO in a Rat Experimental Autoimmune Myocarditis Model: A Comparison Study between [<sup>18</sup>F]Fluoromethyl-PBR28 and [<sup>18</sup>F]CB251. ( 29342117 )
2018
8
Acute myocarditis secondary to acute<i>Campylobacter jejuni</i>infection. ( 29436448 )
2018
9
Is the higher incidence of clozapine induced myocarditis in Australia due to awareness and monitoring? ( 29907491 )
2018
10
Treatment options in myocarditis and inflammatory cardiomyopathy : Focus on i.a8^v. immunoglobulins. ( 29947834 )
2018
11
Myocarditis following diphtheria, whole-cell pertussis, and tetanus toxoid vaccination in a young infant. ( 29922028 )
2018
12
Hypereosinophilic Syndrome Complicated by Eosinophilic Myocarditis With Dramatic Response to Steroid. ( 29581993 )
2018
13
Urinary candidate biomarkers in an experimental autoimmune myocarditis rat model. ( 29524647 )
2018
14
Acute myocarditis with thrombus near left ventricular outflow tract. ( 29457263 )
2018
15
Myocarditis: An Interleukin-1-Mediated Disease? ( 29951067 )
2018
16
CD80 Regulates Th17 Cell Differentiation in Coxsackie Virus B3-Induced Acute Myocarditis. ( 29039143 )
2018
17
Myocardial inflammation detected by cardiac MRI in Arrhythmogenic right ventricular cardiomyopathy: A paediatric case series. ( 29885824 )
2018
18
Vasoactive Intestinal Peptide Ameliorates Acute Myocarditis and Atherosclerosis by Regulating Inflammatory and Autoimmune Responses. ( 29669783 )
2018
19
A Case of dilated Cardiomyopathy with Eosinophilic Granulomatosis with Polyangiitis in which Active Myocardial Inflammation was Only Detected by Endomyocardial Biopsy. ( 29709930 )
2018
20
Incremental value of cardiovascular magnetic resonance feature tracking derived atrial and ventricular strain parameters in a comprehensive approach for the diagnosis of acute myocarditis. ( 29857857 )
2018
21
Hemoadsorption in cardiac shock with biventricular failure and giant-cell myocarditis: A case report. ( 29843541 )
2018
22
Ulinastatin Protects against CVB3-Induced Acute Viral Myocarditis through Nrf2 Activation. ( 29383542 )
2018
23
Pancreatitis and myocarditis coexistence due to infection by Coxsackie B1 and B4 viruses. ( 29375831 )
2018
24
Myocarditis in a girl with mixed connective tissue disease. ( 29624816 )
2018
25
Fulminant giant-cell myocarditis on mechanical circulatory support: Management and outcomes of a French multicentre cohort. ( 29306448 )
2018
26
Case report of severe myocarditis in an immunocompromised child with Respiratory Syncytial Virus infection. ( 29433478 )
2018
27
Electrocardiographic Predictors of Morbidity and Mortality in Patients With Acute Myocarditis: The Importance of QRS-T Angle. ( 29158065 )
2018
28
FGL2 knockdown improves heart function through regulation of TLR9 signaling in the experimental autoimmune myocarditis rats. ( 29128901 )
2018
29
MR imaging of catecholamine-mediated myocarditis complicated by left ventricular thrombus. ( 29396086 )
2018
30
Giant Cell Polymyositis and Myocarditis in a Patient With Thymoma and Myasthenia Gravis: A Postviral Autoimmune Process? ( 29850899 )
2018
31
Ferumoxytol-enhanced magnetic resonance imaging in acute myocarditis. ( 28986407 )
2018
32
<i>Astragalus mongholicus (Fisch.) Bge</i> Improves Peripheral Treg Cell Immunity Imbalance in the Children With Viral Myocarditis by Reducing the Levels of miR-146b and miR-155. ( 29977885 )
2018
33
When the heart gets the flu: Fulminant influenza B myocarditis: A case-series report and review of the literature. ( 29929152 )
2018
34
Circulating MicroRNAs: a Potential Biomarker for Cardiac Damage, Inflammatory Response, and Left Ventricular Function Recovery in Pediatric Viral Myocarditis. ( 29916103 )
2018
35
Sirolimus for Recurrent Giant Cell Myocarditis After Heart Transplantation: A Unique Therapeutic Strategy. ( 29889677 )
2018
36
A Case of Myocarditis and Near-Lethal Arrhythmia Associated With Interleukin-2 Therapy. ( 29399586 )
2018
37
Myocarditis secondary to smallpox vaccination. ( 29572367 )
2018
38
Giant cell myocarditis causing refractory ventricular tachycardia in a pediatric patient. ( 29636926 )
2018
39
Recurrent ventricular arrhythmia in a patient with aortitis and myocardial inflammation due to possible immunoglobulin G4-related disease. ( 29722185 )
2018
40
Phaeochromocytoma found on cardiovascular magnetic resonance in a patient presenting with acute myocarditis: an unusual association. ( 29884661 )
2018
41
Myocarditis as a Form of Presentation of an Inflammatory Autoimmune Myopathy Associated With Anti-signal Recognition Particle Antibodies. ( 29970348 )
2018
42
Early use of anakinra in adult-onset Still's disease myocarditis. ( 29291663 )
2018
43
Myocarditis with tremelimumab plus durvalumab combination therapy for endometrial cancer: A case report. ( 29922709 )
2018
44
Non-invasive differentiation of idiopathic inflammatory myopathy with cardiac involvement from acute viral myocarditis using cardiovascular magnetic resonance imaging T1 and T2 mapping. ( 29429407 )
2018
45
Various Cardiac Abnormalities Caused by Bacterial Myocarditis. ( 29375113 )
2018
46
The dynamic changes in myocardial collagen metabolism in experimental autoimmune myocarditis rats. ( 29305900 )
2018
47
Levitronix bilateral ventricular assist device, a bridge to recovery in a patient with acute fulminant myocarditis and concomitant cerebellar infarction. ( 29443352 )
2018
48
Rare Presentation of Catastrophic Antiphospholipid Syndrome with Myocarditis in Post-partum Period: Case Report and Review of Literature. ( 29391679 )
2018
49
Murine model of acute myocarditis and cerebral cortical neuron edema induced by coxsackievirus B4. ( 29511145 )
2018
50
Reg3I^ from cardiomyocytes regulated macrophage migration, proliferation and functional skewing in experimental autoimmune myocarditis. ( 29755853 )
2018

Variations for Myocarditis

ClinVar genetic disease variations for Myocarditis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ABCD1 NM_000033.3(ABCD1): c.1866-1G> C single nucleotide variant Likely pathogenic GRCh37 Chromosome X, 153008674: 153008674
2 ABCD1 NM_000033.3(ABCD1): c.1866-1G> C single nucleotide variant Likely pathogenic GRCh38 Chromosome X, 153743220: 153743220
3 AMER1 NM_152424.3(AMER1): c.1911_1912delGA (p.Glu637Aspfs) deletion Uncertain significance GRCh38 Chromosome X, 64191375: 64191376
4 AMER1 NM_152424.3(AMER1): c.1911_1912delGA (p.Glu637Aspfs) deletion Uncertain significance GRCh37 Chromosome X, 63411255: 63411256

Expression for Myocarditis

Search GEO for disease gene expression data for Myocarditis.

Pathways for Myocarditis

Pathways related to Myocarditis according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 CD40 CD40LG CD55 CD86 CXADR DSP
2
Show member pathways
13.37 CD40 CD40LG CD86 CXADR HLA-B HLA-DQB1
3
Show member pathways
13.22 CD40 CD40LG CD86 HLA-B HLA-DQB1 HLA-DRB4
4
Show member pathways
12.9 HLA-B HLA-DQB1 HLA-DRB4 ITGB2 MYH6
5
Show member pathways
12.75 HLA-B HLA-DQB1 HLA-DRB4 ICAM1 TNF
6
Show member pathways
12.4 HLA-DQB1 HLA-DRB4 IL12RB1 TNF
7
Show member pathways
12.38 DAG1 DMD DSP ITGB2
8
Show member pathways
12.35 CD40 CD40LG CD86 HLA-DQB1 HLA-DRB4
9 12.35 CD40 HLA-B HLA-DQB1 HLA-DRB4 ICAM1 ITGB2
10
Show member pathways
12.3 ICAM1 ITGB2 MYH6 NOS2
11
Show member pathways
12.24 CD40 CD40LG CD55 CD86 CXADR DAG1
12 12.23 CD40 HLA-B HLA-DQB1 HLA-DRB4 ICAM1
13
Show member pathways
12.17 DAG1 DMD MYH6 TNF
14 12.16 HLA-DQB1 HLA-DRB4 ITGB2 NOS2 TNF
15
Show member pathways
12.12 CD86 HLA-DQB1 HLA-DRB4 IL12RB1
16 12.09 HLA-B HLA-DQB1 HLA-DRB4 ITGB2
17
Show member pathways
12.07 CD40 CD40LG HLA-DQB1 HLA-DRB4 ITGB2 NOS2
18 12.04 CD40 CD40LG CXADR HLA-B ICAM1 ITGB2
19 11.99 CXADR DSP ICAM1 ITGB2
20 11.93 ICAM1 ITGB2 NOS2 TNF
21 11.85 CD55 HLA-DQB1 HLA-DRB4 TNF
22 11.84 ITGB2 NOS2 TNF
23 11.83 CD40 CD40LG ICAM1 TNF
24 11.72 ITGB2 NOS2 TNF
25 11.72 CD40 CD40LG CD86 HLA-B HLA-DQB1 HLA-DRB4
26
Show member pathways
11.7 CD40 CD40LG TNF
27 11.68 CD86 HLA-DQB1 HLA-DRB4
28
Show member pathways
11.6 CD40LG ICAM1 NOS2 TNF
29 11.59 CD86 HLA-DQB1 HLA-DRB4 ICAM1 ITGB2 TNF
30 11.58 CD40 CD40LG CD86
31 11.54 CD40 CD40LG CD86
32 11.53 HLA-DQB1 HLA-DRB4 ICAM1 ITGB2
33 11.49 CD86 ICAM1 TNF
34 11.48 ICAM1 ITGB2 TNF
35 11.47 ITGB2 NOS2 TNF
36 11.41 CD40 CD40LG ICAM1 ITGB2 TNF
37 11.35 HLA-B ICAM1 NOS2
38 11.29 CD40 CD40LG CD86
39 10.89 ICAM1 TNF
40 10.55 MB NOS2

GO Terms for Myocarditis

Cellular components related to Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.7 CD40 CD40LG CD86 DAG1 ICAM1 ITGB2
2 filopodium GO:0030175 9.63 CXADR DAG1 DMD
3 cell surface GO:0009986 9.61 CD40 CD40LG CD55 CD86 DMD HLA-B
4 ER to Golgi transport vesicle membrane GO:0012507 9.58 HLA-B HLA-DQB1 HLA-DRB4
5 ficolin-1-rich granule membrane GO:0101003 9.54 CD55 DSP ITGB2
6 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.5 HLA-B HLA-DQB1 HLA-DRB4
7 dystrophin-associated glycoprotein complex GO:0016010 9.48 DAG1 DMD
8 membrane raft GO:0045121 9.17 CD55 CXADR DAG1 DMD ICAM1 ITGB2
9 plasma membrane GO:0005886 10.16 CD40 CD40LG CD55 CD86 CXADR DAG1
10 extracellular exosome GO:0070062 10.13 CD40 CD55 CD86 DAG1 DSP HLA-B

Biological processes related to Myocarditis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.97 CD40 CD40LG CD86 HLA-B HLA-DQB1 TNF
2 inflammatory response GO:0006954 9.95 CD40 CD40LG ITGB2 NOS2 TNF
3 viral process GO:0016032 9.93 CD55 CD86 CXADR DAG1 HLA-B ICAM1
4 leukocyte migration GO:0050900 9.87 CXADR ICAM1 ITGB2 TNF
5 extracellular matrix organization GO:0030198 9.86 DAG1 ICAM1 ITGB2 TNF
6 cytokine-mediated signaling pathway GO:0019221 9.85 CD86 ICAM1 IL12RB1 ITGB2 NOS2 TNF
7 cellular response to interferon-gamma GO:0071346 9.77 ICAM1 IL12RB1 NOS2
8 T cell costimulation GO:0031295 9.73 CD40LG CD86 HLA-DQB1 HLA-DRB4
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.72 CD40 CD40LG ICAM1 ITGB2 TNF
10 interferon-gamma-mediated signaling pathway GO:0060333 9.71 HLA-B HLA-DQB1 HLA-DRB4 ICAM1
11 positive regulation of nitric oxide biosynthetic process GO:0045429 9.7 ICAM1 ITGB2 TNF
12 leukocyte cell-cell adhesion GO:0007159 9.65 CD40LG ICAM1 ITGB2
13 cellular response to lipopolysaccharide GO:0071222 9.65 CD40 CD86 ICAM1 NOS2 TNF
14 regulation of immune response GO:0050776 9.63 CD40 CD40LG CXADR HLA-B ICAM1 ITGB2
15 cardiac muscle fiber development GO:0048739 9.58 CXADR MYH6
16 response to denervation involved in regulation of muscle adaptation GO:0014894 9.58 DAG1 DMD
17 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.54 ICAM1 TNF
18 cellular extravasation GO:0045123 9.51 ITGB2 TNF
19 regulation of immunoglobulin secretion GO:0051023 9.13 CD40 CD40LG TNF
20 viral entry into host cell GO:0046718 9.02 CD55 CD86 CXADR DAG1 ICAM1

Molecular functions related to Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 CD40 CD40LG CD55 CD86 CXADR DAG1
2 cell adhesion molecule binding GO:0050839 9.33 CXADR DSP ITGB2
3 vinculin binding GO:0017166 9.32 DAG1 DMD
4 dystroglycan binding GO:0002162 9.26 DAG1 DMD
5 virus receptor activity GO:0001618 9.02 CD55 CD86 CXADR DAG1 ICAM1

Sources for Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
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54 NINDS
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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