MCID: MYC008
MIFTS: 59

Myocarditis

Categories: Cardiovascular diseases, Immune diseases, Infectious diseases, Muscle diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Myocarditis

Summaries for Myocarditis

GARD : 20 Myocarditis is a condition that is characterized by inflammation of the heart muscle (myocardium). Some affected people have no noticeable symptoms of the condition. When present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. Myocarditis can be caused by a variety of factors including infections (viral, bacterial, parasitic, and fungal), allergic reactions to certain medications, and exposure to certain chemicals. It can also be associated with other inflammatory conditions such as lupus, Wegener's granulomatosis, giant cell arteritis and Takayasu's arteritis. Most cases occur sporadically in people with no family history of the condition. Treatment aims to address the underlying cause of the condition. Medications and rarely, a heart transplant may be needed if the heart muscle becomes weak.

MalaCards based summary : Myocarditis, also known as myocardial inflammation, is related to giant cell myocarditis and acute myocarditis. An important gene associated with Myocarditis is ABCD1 (ATP Binding Cassette Subfamily D Member 1), and among its related pathways/superpathways are Viral myocarditis and Innate Immune System. The drugs Adalimumab and Abatacept have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and endothelial, and related phenotypes are cellular and cardiovascular system

Disease Ontology : 12 An extrinsic cardiomyopathy that is characterized as an inflammation of the heart muscle.

Wikipedia : 74 Myocarditis, also known as inflammatory cardiomyopathy, is inflammation of the heart muscle. Symptoms... more...

Related Diseases for Myocarditis

Diseases in the Myocarditis family:

Autoimmune Myocarditis Acute Myocarditis
Infectious Myocarditis

Diseases related to Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 913)
# Related Disease Score Top Affiliating Genes
1 giant cell myocarditis 33.0 MB HLA-B
2 acute myocarditis 32.7 TNF NPPB MB CD86 CD40
3 interstitial myocarditis 32.6 MB DMD
4 drug reaction with eosinophilia and systemic symptoms 32.1 TNF HLA-B
5 chagas disease 32.0 TNF NPPB NOS2 IL6
6 cardiogenic shock 31.9 TNF NPPB IL6
7 atrial standstill 1 31.6 NPPB MYH6 DSP DMD
8 pericarditis 31.6 TNF NPPB IL6
9 myositis 31.4 TNF MB IL6 HLA-B DMD
10 allergic disease 31.4 TNF IL6 CD86 CD40
11 sarcoidosis 1 31.4 TNF ICAM1 HLA-DQB1 CD86
12 congestive heart failure 31.4 TNF NPPB MYH6 IL6
13 dilated cardiomyopathy 31.3 TNF NPPB NOS2 MYH6 MB IL6
14 myasthenia gravis 31.2 TNF HLA-DQB1 HLA-B CD86 CD55
15 mumps 31.2 TNF IL6 HLA-DQB1
16 typhoid fever 31.2 TNF IL6 HLA-DQB1
17 lupus erythematosus 31.1 TNF HLA-DQB1 CD86 CD40LG CD40
18 kawasaki disease 31.1 TNF NPPB IL6 CD40
19 autoimmune disease 31.0 TNF IL6 HLA-DQB1 HLA-B CD86 CD55
20 pulmonary edema 31.0 TNF NPPB NOS2 ICAM1
21 meningoencephalitis 31.0 TNF IL6 CD40LG
22 vasculitis 31.0 TNF ITGB2 IL6 ICAM1 HLA-B CD40LG
23 toxoplasmosis 31.0 TNF IL6 HLA-DQB1 CD40LG CD40
24 respiratory failure 30.9 TNF NPPB IL6 ICAM1 DMD
25 ischemia 30.9 NPPB NOS2 MB ICAM1
26 dengue disease 30.9 TNF ICAM1 CD40LG
27 chlamydia 30.9 TNF NOS2 IL6
28 rheumatic fever 30.9 TNF NPPB IL6 ICAM1 HLA-DQB1
29 lyme disease 30.9 TNF IL6 HLA-DQB1 CD40LG
30 pneumonia 30.9 TNF MB IL6 ICAM1 CD40LG
31 guillain-barre syndrome 30.9 TNF ICAM1 HLA-DQB1
32 mixed connective tissue disease 30.8 TNF IL6 CD40LG
33 rheumatic heart disease 30.8 TNF NPPB IL6 HLA-DQB1
34 brucellosis 30.8 TNF IL6 CD86
35 hypertrophic cardiomyopathy 30.8 TNF NPPB MYH6 MB IL6 DSP
36 arrhythmogenic right ventricular cardiomyopathy 30.8 NPPB MYH6 DSP DMD DAG1
37 toxic shock syndrome 30.8 TNF NOS2 IL6 CD86 CD40LG CD40
38 proteasome-associated autoinflammatory syndrome 1 30.8 TNF NOS2 IL6 ICAM1
39 gas gangrene 30.8 MB IL6 DMD DAG1
40 dengue hemorrhagic fever 30.8 TNF IL6 ICAM1 HLA-B
41 encephalitis 30.8 TNF NOS2 IL6 ABCD1
42 thyroiditis 30.8 TNF IL6 CD40
43 coronary stenosis 30.8 NPPB IL6 ICAM1
44 rubella 30.7 TNF IL6 HLA-DQB1 HLA-B CD40LG
45 common cold 30.7 TNF IL6 ICAM1
46 glomerulonephritis 30.7 NOS2 ICAM1 CD55 CD40LG
47 acquired immunodeficiency syndrome 30.7 TNF NOS2 IL6 ICAM1 HLA-B CD40LG
48 tetanus 30.7 TNF MB IL6 CD40LG
49 angina pectoris 30.7 NPPB MB IL6 ICAM1
50 myocardial infarction 30.7 TNF NPPB MYH6 MB IL6 ICAM1

Comorbidity relations with Myocarditis via Phenotypic Disease Network (PDN):


Acute Cystitis Familial Atrial Fibrillation
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Mitral Valve Disease

Graphical network of the top 20 diseases related to Myocarditis:



Diseases related to Myocarditis

Symptoms & Phenotypes for Myocarditis

MGI Mouse Phenotypes related to Myocarditis:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.36 CD40LG CD86 CXADR DAG1 DMD DSP
2 cardiovascular system MP:0005385 10.34 CD40LG CXADR DAG1 DMD DSP HLA-DQB1
3 homeostasis/metabolism MP:0005376 10.34 ABCD1 CD40 CD40LG CD55 CD86 CXADR
4 hematopoietic system MP:0005397 10.3 ABCD1 CD40 CD40LG CD55 CD86 CXADR
5 immune system MP:0005387 10.28 ABCD1 CD40 CD40LG CD55 CD86 CXADR
6 mortality/aging MP:0010768 10.24 ABCD1 CD40LG CD55 CXADR DAG1 DMD
7 endocrine/exocrine gland MP:0005379 10.22 ABCD1 CD40 CD40LG CD86 CXADR DMD
8 muscle MP:0005369 10.13 CD55 CD86 CXADR DAG1 DMD DSP
9 digestive/alimentary MP:0005381 10.1 CXADR DMD DSP HLA-DQB1 ICAM1 IL6
10 nervous system MP:0003631 10.1 ABCD1 CD40 CD40LG CD86 CXADR DAG1
11 renal/urinary system MP:0005367 9.76 CD40 CD40LG CD55 CXADR DMD HLA-DQB1
12 respiratory system MP:0005388 9.56 CXADR DMD HLA-DQB1 IL6 MB MYH6
13 vision/eye MP:0005391 9.28 ABCD1 DAG1 DMD DSP ICAM1 IL6

Drugs & Therapeutics for Myocarditis

Drugs for Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved, Experimental Phase 4 331731-18-1 16219006
2
Abatacept Approved Phase 4 332348-12-6 10237
3
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
4
Azathioprine Approved Phase 4 446-86-6 2265
5 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,... Phase 4
6 Sodium-Glucose Transporter 2 Inhibitors Phase 4
7 Hypoglycemic Agents Phase 4
8 Anti-Inflammatory Agents Phase 4
9 Hormones Phase 4
10 Hormone Antagonists Phase 4
11 Immunologic Factors Phase 4
12 glucocorticoids Phase 4
13 Antirheumatic Agents Phase 4
14 Antimetabolites Phase 4
15 Antineoplastic Agents, Hormonal Phase 4
16 Immunosuppressive Agents Phase 4
17 Pharmaceutical Solutions Phase 2, Phase 3
18 Hematinics Phase 2, Phase 3
19 Ferrosoferric Oxide Phase 2, Phase 3
20 Parenteral Nutrition Solutions Phase 2, Phase 3
21 Adrenergic beta-Antagonists Phase 2, Phase 3
22 Interleukin 1 Receptor Antagonist Protein Phase 2, Phase 3
23
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
24 Prednisolone acetate Approved, Vet_approved Phase 2 52-21-1
25
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
26
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
27
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
28
Clotrimazole Approved, Vet_approved Phase 2 23593-75-1 2812
29
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
30
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
31
Lenograstim Approved, Investigational Phase 2 135968-09-1
32
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
33 Molgramostim Investigational Phase 2 99283-10-0
34 Methylprednisolone Acetate Phase 2
35 Protective Agents Phase 2
36 Muromonab-CD3 Phase 2
37 Neuroprotective Agents Phase 2
38 Anti-Infective Agents Phase 2
39 Cyclosporins Phase 2
40 Antifungal Agents Phase 2
41 Dermatologic Agents Phase 2
42 Calcineurin Inhibitors Phase 2
43 Antiemetics Phase 2
44 Gastrointestinal Agents Phase 2
45 Adjuvants, Immunologic Phase 2
46
Regadenoson Approved, Investigational 313348-27-5 219024
47
Adenosine Approved, Investigational 58-61-7 60961
48
Nitroglycerin Approved, Investigational 55-63-0 4510
49
Octreotide Approved, Investigational 83150-76-9 383414 6400441
50
Iodine Approved, Investigational 7553-56-2 807

Interventional clinical trials:

(show top 50) (show all 84)
# Name Status NCT ID Phase Drugs
1 A Randomized, Double-blind, Placebo-controlled, Multi-center Clinical Trial of the Effect of Danhong Injection on Microcirculation in the Treatment of Patients With STEMI(ST- Elevation Myocardical Infarction) After the PTCA Surgery. Unknown status NCT02158559 Phase 4 Danhong Injection;Normal Saline
2 Effects of SGLT-2 Inhibition With Dapagliflozin on Myocardial Fibrosis and Inflammation as Assessed by Cardiac MRI With T1- and T2-mapping in Patients With Type-2 Diabetes Unknown status NCT03782259 Phase 4 dapagliflozin
3 Effects of Abatacept on Myocarditis in Rheumatoid Arthritis Recruiting NCT03619876 Phase 4 Abatacept;Adalimumab
4 A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy of Immunosuppression in Biopsy-proven Virus Negative Myocarditis or Inflammatory Cardiomyopathy Not yet recruiting NCT04654988 Phase 4 Prednisone;Azathioprine;Placebo Prednisone;Placebo Azathioprine
5 RANDOMIZED, MULTICENTRIC STUDY COMPARING THE EFFECT OF TWO REGIMENS OF COMBINED IMMUNOSUPPRESSIVE THERAPY IN THE TREATMENT OF INFLAMMATORY CARDIOMYOPATHY CZECH-ICIT (CZECH INFLAMMATORY CARDIOMYOPATHY IMMUNOSUPPRESSION TRIAL) Unknown status NCT01877746 Phase 3 Combination of prednisone and azathioprine;Combination of prednisone and azathioprine
6 DEtection of Cellular Inflammation With FERumoxytol in the HEART Completed NCT02319278 Phase 2, Phase 3 Ferumoxytol
7 Anakinra Versus Placebo Double Blind Randomized Controlled Trial for the Treatment of Acute MyocarditIS Recruiting NCT03018834 Phase 2, Phase 3 ANAKINRA 100 mg/daily subcutaneously;Placebo
8 Outcome of Myocardial Inflammation After Steroid Therapy in Thai Systemic Sclerosis Patients: an Open Label Study Completed NCT03607071 Phase 2 Prednisolone and taper
9 Phase II Randomized Study of Muromonab-CD3, Cyclosporine, Methylprednisolone, and Prednisone in Patients With Giant Cell Myocarditis Completed NCT00004482 Phase 2 Cyclosporine;methylprednisolone;Muromonab-CD3;prednisone
10 Myocarditis Treatment Trial Completed NCT00000524 Phase 2 cyclosporine;prednisone
11 Prospective, Double-blind, Randomized, Placebo-controlled Phase II Clinical Trial for Evaluation of G-CSF in Patients With Chronic Chagas Cardiomyopathy Completed NCT02154269 Phase 2 Treatment with G-CSF (Granulocyte colony stimulating factor);Placebo saline
12 18F-FSPG PET/MRI or PET/CT Imaging of Cardiac Sarcoidosis or Inflammation Recruiting NCT03103490 Phase 2 18F-FSPG
13 Prospective Assessment of the Clinical Utility of Cardiovascular Magnetic Resonance in Patients With Suspected Acute Myocarditis - A Pilot Study for Establishing an International Registry Unknown status NCT01307735
14 Risk Assessment of Cardiac ARrhythmias in Patients With MYocarditis Unknown status NCT03801681
15 Risk of Muscle Damage in Cancer Patients Exposed to the Influenza Vaccine While Receiving Checkpoint Inhibitor Therapies: A Nested Case Control Study Using Claims Data Unknown status NCT03644498
16 Myocardial Inflammation in Systemic Lupus Erythematosus Unknown status NCT01761422
17 PET-detected Myocardial Inflammation is a Characteristic of Cardiac Sarcoid But Not of ARVC - a Feasibility Study Unknown status NCT02989480
18 Determining the Mechanism of Myocardial Injury and Role of Coronary Disease in Type 2 Myocardial Infarction Unknown status NCT03338504
19 Monocentric Interventionnal Pilot Study Pilot Study Evaluating Somatostatin Receptor's PET Imaging to Detect Inflammatory Phases of Myocarditis Unknown status NCT03347760 DOTATOC-68Ga PET initial;DOTATOC-68Ga PET at 6 months
20 DZHK TranslatiOnal Registry for CardiomyopatHies Deutsches Zentrum für Herz- Und Kreislauf-Forschung (DZHK) Unknown status NCT02187263
21 Oxidant-antioxidant Activity, Free Radicle Activity, Immune Response and Biomarkers in ECMO Patients Unknown status NCT01089036
22 Urinary Excretion of Enteroviruses From Children With a Presumed Enteroviral Infection Completed NCT00426699
23 Clinical, Morphological and Functional Aspects in Acute and Chronic Myocarditis. Completed NCT04217876
24 Inflammatory Cardiomyopathy Cohort of the SFB/TR19 [Kohorte "Entzündliche Kardiomyopathien" Des Sonderforschungsbereichs/Transregio 19 (SFB/TR19)] Completed NCT02970227
25 Predictive Value of CMR Features in Patients With Suspected Myocarditis Completed NCT03470571
26 Myocarditis and the Role of Advanced Magnetic Resonance Imaging Completed NCT02177630
27 Value of CMR Including T1 Mapping in Patients With Acute Myocarditis Completed NCT01962584
28 Giant Cell Myocarditis Treatment Trial Pilot Study Completed NCT00027443 Muromonab-CD3;Cyclosporine
29 Risk Factors Influenced Prognosis of Acute Fulminant Myocarditis by Analyzing Clinical Characteristics and Complications, Laboratory Findings, Treatments, and Electrocardiographic and Echocardiographic Data. Completed NCT03219996
30 Cardiac Magnetic Resonance in Acute Myocarditis Completed NCT02299856
31 Role of Electrocardiograms in Risk Stratification and Analysis of the Characteristics of ST Elevation in Acute Myocarditis: A Two-center Study Completed NCT04498494
32 Cardiac Repercussion of Systemic Sclerodermias : Detection of Infra-clinical Abnormalities by Analysis of the Myocardic Regional Function Using Myocardial Tissular Doppler Mode. Completed NCT00697736
33 ACAM2000® Myopericarditis Registry Completed NCT01395082
34 The Role of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Children With Acute Inflammatory Cardiomyopathy Completed NCT00693134
35 Evaluation of Reporting of Immune Checkpoint Inhibitor Associated Cardio-vascular Adverse Reactions Using International Pharmacovigilance Database Completed NCT03387540 ICI
36 Cologne Register of Wearable Defibrillator (CRWD) Completed NCT02073942
37 Evaluation of MyoStrain™ in Clinical Practice Completed NCT03825224
38 Impact of 100mL Lipid Emulsion for Intravenous for Suppression of Myocardial Glucose Completed NCT04437927
39 Cardiac Involvement in Coronavirus (SARS-Cov-2) Infected Health Care Workers: The CCC Study Completed NCT04413071
40 Myocarditis Registry for Children and Adolescents - MYKKE Recruiting NCT02590341
41 Follow-up of the Inflammatory Cardiomyopathy Cohort of SFB/TR19 Recruiting NCT02971267
42 Cardiac Magnetic Resonance Evaluation of Myocardial Inflammation Persistence After Acute Myocarditis: Prognostic Relevance Recruiting NCT03525639
43 Myocardial Inflammation in Rheumatoid Arthritis: A Descriptive Study Recruiting NCT03776682
44 Multiparametric Tissue Characterisation of Myocardial Inflammation in Autoimmune Rheumatic Diseases (AIRD) Using Cardiovascular Magnetic Resonance Imaging Recruiting NCT04673409
45 Validation of Cardiovascular Magnetic Resonance Against Invasive Haemodynamics in Patients With Heart Failure With Preserved Ejection Fraction (DECIPHER HFpEF) Recruiting NCT03251183
46 EARLY-MYO-Myocarditis (EARLY Assessment of MYOcardial Tissue Characteristics by CMR in Myocarditis) Registry Recruiting NCT04338113
47 Hospital Registry of Acute Myocarditis: Evolution of the Proportion of Positive SARS-COV-2 Cases During the Covid-19 Pandemic, Case Characteristics and Prognoses Recruiting NCT04375748
48 Monitoring Drug-induced Myocarditis Recruiting NCT03855982 Drug inducing myocarditis
49 Analysis of Sympathetic Activity in Willis-Ekbom Disease Recruiting NCT02929732
50 Recurrent Acute Myocarditis : Characteristics, Etiology, Prognosis and Genetic Basis. Recruiting NCT04589156

Search NIH Clinical Center for Myocarditis

Cochrane evidence based reviews: myocarditis

Genetic Tests for Myocarditis

Anatomical Context for Myocarditis

MalaCards organs/tissues related to Myocarditis:

40
Heart, T Cells, Endothelial, Bone Marrow, Cardiac Myocytes, Myeloid, Skeletal Muscle

Publications for Myocarditis

Articles related to Myocarditis:

(show top 50) (show all 16512)
# Title Authors PMID Year
1
Cardiac involvement in a female carrier of Duchenne muscular dystrophy. 61 54
18706718 2010
2
IFN-alpha expression and antiviral effects are subtype and cell type specific in the cardiac response to viral infection. 54 61
19896686 2010
3
Remodeling of dystrophin and sarcomeric Z-band occurs in pediatric cardiomyopathies: a unifying mechanism for force transmission defect. 54 61
19194174 2009
4
Cardiac natriuretic peptides gene expression and secretion in inflammation. 54 61
19158604 2009
5
Activation of STAT1 transcription factor precedes up-regulation of coxsackievirus-adenovirus receptor during viral myocarditis. 54 61
18329552 2008
6
[The expression of coxsackie B virus adenovirus receptor (CAR) in viral myocarditis and dilated cardiomyopathy patients]. 61 54
17896511 2007
7
From oxygen sensing to heart failure: role of thioredoxin. 54 61
17511584 2007
8
Determinants of brain natriuretic peptide gene expression and secretion in acute cardiac allograft rejection. 54 61
17284995 2007
9
[Change in plasma N-terminal pro-brain natriuretic peptide in children with Kawasaki disease and its value in clinical practice]. 61 54
17254452 2006
10
Sex differences in coxsackievirus B3-induced myocarditis: IL-12Rbeta1 signaling and IFN-gamma increase inflammation in males independent from STAT4. 61 54
16949558 2006
11
Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis. 61 54
17039570 2006
12
Virus receptor trap neutralizes coxsackievirus in experimental murine viral myocarditis. 54 61
16806133 2006
13
TNFR-Fc fusion protein expressed by in vivo electroporation improves survival rates and myocardial injury in coxsackievirus induced murine myocarditis. 61 54
16631119 2006
14
The osteopontin - CD44 pathway is superfluous for the development of autoimmune myocarditis. 61 54
16402410 2006
15
[The expression of dystrophin in human viral myocarditis and dilated cardiomyopathy]. 61 54
16524176 2006
16
Successful treatment of experimental autoimmune myocarditis by adenovirus-mediated gene transfer of antisense CIITA. 61 54
15808836 2005
17
Is diagnostic myocardial biopsy useful in the XXI century? 61 54
15928740 2005
18
Exogenous thioredoxin reduces inflammation in autoimmune myocarditis. 61 54
15353510 2004
19
Overexpression of tumor necrosis factor (TNF)alpha and TNFalpha receptor I in human viral myocarditis: clinicopathologic correlations. 54 61
15218506 2004
20
Dystrophin disruption in enterovirus-induced myocarditis and dilated cardiomyopathy: from bench to bedside. 61 54
12920582 2004
21
Spatiotemporal changes of coxsackievirus and adenovirus receptor in rat hearts during postnatal development and in cultured cardiomyocytes of neonatal rat. 61 54
14624362 2004
22
Animal models for autoimmune myocarditis and autoimmune thyroiditis. 61 54
15286386 2004
23
Upregulation of redox-regulating protein, thioredoxin, in endomyocardial biopsy samples of patients with myocarditis and cardiomyopathies. 61 54
12870673 2003
24
Viral causes of cardiac inflammation. 54 61
12826818 2003
25
Analysis of the coxsackievirus B-adenovirus receptor gene in patients with myocarditis or dilated cardiomyopathy. 61 54
12409275 2002
26
Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death. 54 61
11901182 2002
27
Brain natriuretic peptide can be a useful biochemical marker for myocarditis in patients with Kawasaki disease. 54 61
12018720 2002
28
The role of interferon regulatory factors in the cardiac response to viral infection. 61 54
11952139 2002
29
Molecular genetics of left ventricular dysfunction. 61 54
11899244 2001
30
Arrhythmogenic inherited heart muscle diseases in children. 61 54
11781950 2001
31
Interferon regulatory factor 3 is required for viral induction of beta interferon in primary cardiac myocyte cultures. 61 54
10559337 1999
32
Anti-mitochondrial antibodies in patients with dilated cardiomyopathy (anti-M7) are directed against flavoenzymes with covalently bound FAD. 54 61
9528896 1998
33
Cardiac troponin T in patients with clinically suspected myocarditis. 54 61
9350939 1997
34
iNOS expression and nitrotyrosine formation in the myocardium in response to inflammation is controlled by the interferon regulatory transcription factor 1. 61 54
9244230 1997
35
Expression of inducible nitric oxide synthase in rat experimental autoimmune myocarditis with special reference to changes in cardiac hemodynamics. 61 54
8978317 1997
36
Venticular expression of atrial and brain natriuretic peptides in patients with myocarditis. 54 61
8789180 1995
37
Role of nitric oxide in the regulation of myocardial function. 61 54
7568904 1995
38
A case of creatine kinase isomer anomaly in relation to the diagnosis of acute myocardial infarction. 54 61
8051787 1994
39
[Autoantibodies against the beta 1-adrenergic receptor in myocarditis and dilated cardiomyopathy: localization of two epitopes]. 54 61
1283934 1992
40
[The significance of myoglobin determination in the differential diagnosis of chest pain syndrome]. 61 54
2053302 1991
41
Relation between myoglobin and cardiac dysfunction in myocarditis--immunohistochemical study of endomyocardial biopsy specimens. 54 61
2010944 1991
42
Vagus nerve plays a pivotal role in CD4+ T cell differentiation during CVB3-induced murine acute myocarditis. 61
33380272 2021
43
Myocardial protection by heparin-based coacervate of FGF10. 61
33336117 2021
44
Commercial Air Travel for Passengers With Cardiovascular Disease: Recommendations for Less Common Conditions, Considerations for Venous Thromboembolism, and General Guidance. 61
33412348 2021
45
Acute myocardial infarction secondary to COVID-19 infection: A case report and review of the literature. 61
33296828 2021
46
Case report and systematic review suggest that children may experience similar long-term effects to adults after clinical COVID-19. 61
33205450 2021
47
Cardiac Magnetic Resonance Imaging in Coronavirus Disease 2019 (COVID-19): A Systematic Review of Cardiac Magnetic Resonance Imaging Findings in 199 Patients. 61
33306666 2021
48
Myocardial Infarction Without Obstructive Coronary Artery Disease (MINOCA): A Practical Guide for Clinicians. 61
33360675 2021
49
Myocarditis and inflammatory cardiomyopathy: current evidence and future directions. 61
33046850 2021
50
Chagas Disease: Chronic Chagas Cardiomyopathy. 61
31983471 2021

Variations for Myocarditis

ClinVar genetic disease variations for Myocarditis:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 ABCD1 NM_000033.4(ABCD1):c.1866-1G>C SNV Likely pathogenic 523312 rs1557055311 X:153008674-153008674 X:153743220-153743220
2 AMER1 NM_152424.4(AMER1):c.1907_1908GA[2] (p.Glu637fs) Microsatellite Uncertain significance 523561 rs1555933313 X:63411255-63411256 X:64191375-64191376

Expression for Myocarditis

Search GEO for disease gene expression data for Myocarditis.

Pathways for Myocarditis

Pathways related to Myocarditis according to KEGG:

36
# Name Kegg Source Accession
1 Viral myocarditis hsa05416

Pathways related to Myocarditis according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 TNF NOS2 ITGB2 IL6 ICAM1 HLA-DQB1
2
Show member pathways
13.42 ITGB2 ICAM1 HLA-DQB1 HLA-B CXADR CD86
3
Show member pathways
13.29 TNF NOS2 ITGB2 IL6 ICAM1 HLA-DQB1
4
Show member pathways
12.79 TNF IL6 ICAM1 HLA-DQB1 HLA-B CD40
5
Show member pathways
12.6 TNF HLA-DQB1 CD86 CD40LG CD40
6
Show member pathways
12.35 HLA-DQB1 CD86 CD40LG CD40
7
Show member pathways
12.3 NOS2 MYH6 ITGB2 ICAM1
8 12.25 TNF ITGB2 IL6 ICAM1 HLA-DQB1 HLA-B
9
Show member pathways
12.22 TNF MYH6 IL6 DMD DAG1
10
Show member pathways
12.21 TNF NOS2 ITGB2 HLA-DQB1 CD40LG CD40
11
Show member pathways
12.21 TNF MYH6 ITGB2 IL6 ICAM1 HLA-DQB1
12 12.19 TNF NOS2 ITGB2 IL6 HLA-DQB1
13 12.01 ITGB2 ICAM1 HLA-B CXADR CD40LG CD40
14 12 ITGB2 ICAM1 DSP CXADR
15 11.99 TNF NOS2 IL6 ICAM1
16 11.97 ITGB2 ICAM1 HLA-DQB1 HLA-B CD86 CD40LG
17 11.95 TNF NOS2 ITGB2 IL6 ICAM1
18 11.91 TNF ICAM1 CD40LG CD40
19 11.89 TNF NOS2 ITGB2 IL6
20 11.87 TNF IL6 HLA-DQB1 CD55
21 11.77 TNF ITGB2 IL6 ICAM1 HLA-DQB1 CD86
22
Show member pathways
11.76 TNF CD40LG CD40
23 11.74 TNF NOS2 ITGB2 IL6
24
Show member pathways
11.72 TNF IL6 CD86
25
Show member pathways
11.7 TNF CD40LG CD40
26 11.63 TNF IL6 DSP
27
Show member pathways
11.63 TNF NOS2 IL6 ICAM1 CD40LG
28 11.58 TNF ITGB2 IL6
29 11.52 TNF IL6 ICAM1 CD86
30 11.49 TNF NOS2 ITGB2
31 11.49 TNF ITGB2 IL6 ICAM1
32 11.37 NOS2 ICAM1 HLA-B
33 11.37 TNF IL6 ICAM1
34 11.33 TNF ITGB2 IL6 ICAM1 CD40LG CD40
35 11.32 TNF NOS2 ITGB2 IL6 ICAM1 CD40LG
36 11.31 CD86 CD40LG CD40
37 10.56 NOS2 MB

GO Terms for Myocarditis

Cellular components related to Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.1 TNF NOS2 ITGB2 ICAM1 HLA-DQB1 HLA-B
2 extracellular exosome GO:0070062 10.06 MB ITGB2 ICAM1 HLA-B DSP DAG1
3 extracellular space GO:0005615 9.97 TNF NPPB MIR590 IL6 ICAM1 DAG1
4 external side of plasma membrane GO:0009897 9.7 TNF ITGB2 ICAM1 DAG1 CD86 CD40LG
5 filopodium GO:0030175 9.61 DMD DAG1 CXADR
6 ficolin-1-rich granule membrane GO:0101003 9.54 ITGB2 DSP CD55
7 membrane raft GO:0045121 9.5 TNF ITGB2 ICAM1 DMD DAG1 CXADR
8 cell surface GO:0009986 9.28 TNF ITGB2 ICAM1 HLA-B DMD CD86

Biological processes related to Myocarditis according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.99 ICAM1 HLA-B DAG1 CXADR CD86 CD55
2 immune response GO:0006955 9.95 TNF IL6 HLA-DQB1 HLA-B CD86 CD40LG
3 inflammatory response GO:0006954 9.93 TNF NOS2 ITGB2 IL6 CD40LG CD40
4 extracellular matrix organization GO:0030198 9.92 TNF ITGB2 ICAM1 DAG1
5 cytokine-mediated signaling pathway GO:0019221 9.91 TNF NOS2 ITGB2 IL6 ICAM1 CD86
6 leukocyte migration GO:0050900 9.86 TNF ITGB2 ICAM1 CXADR
7 regulation of immune response GO:0050776 9.8 ITGB2 ICAM1 HLA-B CXADR CD40LG CD40
8 regulation of insulin secretion GO:0050796 9.78 TNF NOS2 IL6
9 interferon-gamma-mediated signaling pathway GO:0060333 9.77 ICAM1 HLA-DQB1 HLA-B
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.77 TNF IL6 CD40
11 positive regulation of T cell proliferation GO:0042102 9.74 IL6 CD86 CD40LG
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.7 TNF ITGB2 ICAM1
13 leukocyte cell-cell adhesion GO:0007159 9.67 ITGB2 ICAM1 CD40LG
14 viral entry into host cell GO:0046718 9.65 ICAM1 DAG1 CXADR CD86 CD55
15 positive regulation of neuroinflammatory response GO:0150078 9.63 TNF IL6
16 cellular response to lipopolysaccharide GO:0071222 9.63 TNF NOS2 IL6 ICAM1 CD86 CD40
17 negative regulation of chemokine production GO:0032682 9.62 MIR590 IL6
18 response to denervation involved in regulation of muscle adaptation GO:0014894 9.61 DMD DAG1
19 negative regulation of lipid storage GO:0010888 9.58 TNF IL6
20 cardiac muscle fiber development GO:0048739 9.58 MYH6 CXADR
21 CD40 signaling pathway GO:0023035 9.58 CD86 CD40LG CD40
22 vascular endothelial growth factor production GO:0010573 9.55 TNF IL6
23 cellular extravasation GO:0045123 9.54 TNF ITGB2
24 regulation of immunoglobulin production GO:0002637 9.54 TNF CD40LG CD40
25 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.43 TNF ITGB2 IL6 ICAM1 CD40LG CD40
26 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 8.92 TNF ITGB2 IL6 ICAM1

Molecular functions related to Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.56 ITGB2 ICAM1 CD86 CD40
2 vinculin binding GO:0017166 9.37 DMD DAG1
3 integrin binding GO:0005178 9.35 ITGB2 ICAM1 DMD CXADR CD40LG
4 cell adhesion molecule binding GO:0050839 9.33 ITGB2 DSP CXADR
5 dystroglycan binding GO:0002162 9.32 DMD DAG1
6 virus receptor activity GO:0001618 9.02 ICAM1 DAG1 CXADR CD86 CD55

Sources for Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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