MCID: MYC001
MIFTS: 18

Myoclonic Cerebellar Dyssynergia

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Myoclonic Cerebellar Dyssynergia

MalaCards integrated aliases for Myoclonic Cerebellar Dyssynergia:

Name: Myoclonic Cerebellar Dyssynergia 12 44 15 73
Dyssynergia Cerebellaris Myoclonica 12 53 54
Dyssynergia Cerebellaris Progressiva 53 54
Dentate Cerebellar Ataxia 53 54
Primary Dentatum Atrophy 53 54
Dentatorubral Atrophy 53 54
Ramsay Hunt Cerebellar Syndrome 53
Progressive Cerebellar Tremor 12
Progressive Myoclonus Ataxia 53
Myoclonus and Ataxia 53

Classifications:



External Ids:

Disease Ontology 12 DOID:12707
ICD10 33 G11.1
MeSH 44 D002527
UMLS 73 C0007761

Summaries for Myoclonic Cerebellar Dyssynergia

NINDS : 54 Dyssynergia Cerebellaris Myoclonica refers to a collection of rare, degenerative, neurological disorders characterized by epilepsy, cognitive impairment, myoclonus, and progressive ataxia.  Symptoms include seizures, tremor, and reduced muscle coordination.  Onset of the disorder generally occurs in early adulthood.  Tremor may begin in one extremity and later spread to involve the entire voluntary muscular system.  Arms are usually more affected than legs.  Some of the cases are due to mitochondrial abnormalities.

MalaCards based summary : Myoclonic Cerebellar Dyssynergia, also known as dyssynergia cerebellaris myoclonica, is related to myoclonus and ataxia and gosr2-related progressive myoclonus ataxia. An important gene associated with Myoclonic Cerebellar Dyssynergia is MT-TK (Mitochondrially Encoded TRNA Lysine). Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Myoclonic Cerebellar Dyssynergia

Diseases related to Myoclonic Cerebellar Dyssynergia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 myoclonus and ataxia 12.2
2 gosr2-related progressive myoclonus ataxia 12.1
3 ramsay hunt syndrome i 11.4
4 cerebelloparenchymal disorder v 11.4
5 epilepsy, progressive myoclonic, 6 11.1
6 myoclonic epilepsy of unverricht and lundborg 11.0
7 geniculate herpes zoster 11.0
8 epilepsy, progressive myoclonic, 10 10.9
9 galactosialidosis 10.9
10 myoclonus 10.2
11 neuroblastoma 9.7
12 mumps 9.7
13 dementia 9.7
14 pellagra 9.7
15 encephalopathy 9.7
16 tay-sachs disease 9.0 CTSA VIM

Graphical network of the top 20 diseases related to Myoclonic Cerebellar Dyssynergia:



Diseases related to Myoclonic Cerebellar Dyssynergia

Symptoms & Phenotypes for Myoclonic Cerebellar Dyssynergia

GenomeRNAi Phenotypes related to Myoclonic Cerebellar Dyssynergia according to GeneCards Suite gene sharing:

26 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.62 VIM
2 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.62 VIM
3 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.62 VIM
4 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.62 VIM CTSA
5 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.62 VIM
6 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.62 VIM
7 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.62 CTSA
8 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.62 CTSA
9 Increased shRNA abundance (Z-score > 2) GR00366-A-215 9.62 CTSA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.62 CTSA
11 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.62 VIM
12 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.62 VIM
13 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.62 CTSA
14 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.62 CTSA
15 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.62 VIM
16 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.62 CTSA
17 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.62 VIM
18 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.62 CTSA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.62 CTSA

Drugs & Therapeutics for Myoclonic Cerebellar Dyssynergia

Search Clinical Trials , NIH Clinical Center for Myoclonic Cerebellar Dyssynergia

Cochrane evidence based reviews: myoclonic cerebellar dyssynergia

Genetic Tests for Myoclonic Cerebellar Dyssynergia

Anatomical Context for Myoclonic Cerebellar Dyssynergia

Publications for Myoclonic Cerebellar Dyssynergia

Articles related to Myoclonic Cerebellar Dyssynergia:

# Title Authors Year
1
Clinical and electroencephalographic investigations in myoclonic cerebellar dyssynergia. ( 14411893 )
1959

Variations for Myoclonic Cerebellar Dyssynergia

Expression for Myoclonic Cerebellar Dyssynergia

Search GEO for disease gene expression data for Myoclonic Cerebellar Dyssynergia.

Pathways for Myoclonic Cerebellar Dyssynergia

GO Terms for Myoclonic Cerebellar Dyssynergia

Sources for Myoclonic Cerebellar Dyssynergia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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