MCID: MYP002
MIFTS: 47

Myoepithelial Carcinoma

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Myoepithelial Carcinoma

MalaCards integrated aliases for Myoepithelial Carcinoma:

Name: Myoepithelial Carcinoma 12 52 15
Malignant Myoepithelioma 52
Myoepithelioma Carcinoma 52

Classifications:



External Ids:

Disease Ontology 12 DOID:4838
NCIt 49 C7596
SNOMED-CT 67 128884000
UMLS 71 C0334699

Summaries for Myoepithelial Carcinoma

NIH Rare Diseases : 52 Myoepithelial carcinoma is a rare malignant (cancerous) tumor that usually occurs in the salivary glands in the mouth, but can also occur in skin and soft tissues . Approximately 66% of these tumors occur in a part of the salivary gland, known as the parotid gland. The average age of diagnosis is 55 years. Symptoms of myoepithelial carcinoma usually begin with a painless mass. Other symptoms vary depending on the site of the tumor and may include: hoarseness, nasal blockage, bleeding from the nose, pain, headaches, and facial weakness and paralysis. Treatment depends on the location and stage of the tumor. Treatment options may include surgery to remove the affected tissues, radiation therapy , and chemotherapy .

MalaCards based summary : Myoepithelial Carcinoma, also known as malignant myoepithelioma, is related to breast myoepithelial carcinoma and rare tumor. An important gene associated with Myoepithelial Carcinoma is EWSR1 (EWS RNA Binding Protein 1), and among its related pathways/superpathways are VEGF Signaling and MicroRNAs in cancer. The drugs Axitinib and Protein Kinase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, breast and lung, and related phenotypes are Increased proliferation and neoplasm

Disease Ontology : 12 A carcinoma that derives from myoepithelial cells.

Related Diseases for Myoepithelial Carcinoma

Diseases related to Myoepithelial Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 456)
# Related Disease Score Top Affiliating Genes
1 breast myoepithelial carcinoma 34.4 VIM KRT14 ACTC1
2 rare tumor 31.8 EWSR1 ACTC1
3 epithelial-myoepithelial carcinoma 31.5 VIM TP53 SMARCB1 PLAG1 PIK3CA KRT7
4 polymorphous low-grade adenocarcinoma 30.8 VIM MUC1 ACTC1
5 chondrosarcoma 30.5 VIM NR4A3 MUC1 EWSR1
6 epithelioid sarcoma 30.5 VIM SMARCB1 MUC1 KRT7
7 hemangiopericytoma, malignant 30.4 VIM MUC1 ACTC1
8 pleomorphic adenoma carcinoma 30.4 TP53 PLAG1 HMGA2
9 rhabdoid cancer 30.2 TP53 SMARCB1 EWSR1
10 skin benign neoplasm 30.2 KRT7 KRT14 HRAS
11 large cell carcinoma 30.2 MUC1 KRT7 HRAS
12 leiomyoma 30.2 VIM HMGA2 ACTC1
13 warthin tumor 30.1 KRT7 KRT18
14 spindle cell sarcoma 30.1 VIM MUC1 KRT7 ACTC1
15 myxoid chondrosarcoma 30.1 SMARCB1 NR4A3 MUC1 EWSR1
16 soft tissue sarcoma 30.1 TP53 EWSR1
17 embryonal sarcoma 30.0 VIM TP53
18 extraosseous chondrosarcoma 30.0 ZNF444 SMARCB1 NR4A3 EWSR1
19 lipomatosis, multiple 29.9 PLAG1 HMGA2 EWSR1
20 neuroendocrine carcinoma 29.9 MUC1 KRT7 KRT18
21 oncocytoma 29.9 VIM MUC1 KRT7 KRT18 KRT14
22 salivary gland carcinoma 29.9 TP53 PLAG1 KRT7
23 adenoma 29.8 TP53 PLAG1 PIK3CA MUC1 KRT7
24 intrahepatic cholangiocarcinoma 29.8 TP53 MUC1 KRT7
25 rhabdoid tumor predisposition syndrome 1 29.8 VIM TP53 SMARCB1 MUC1 ACTC1
26 ewing sarcoma 29.8 VIM TP53 NR4A3 EWSR1
27 neurofibroma 29.7 VIM TP53 MUC1 ACTC1
28 central epithelioid sarcoma 29.7 VIM SMARCB1 KRT7 KRT18
29 fibrosarcoma 29.7 VIM TP53 EWSR1 ACTC1
30 mucoepidermoid carcinoma 29.7 TP53 MUC1 KRT7 KRT14 EWSR1 ACTC1
31 mesenchymal chondrosarcoma 29.7 VIM SMARCB1 MUC1 KRT7 HRAS
32 salivary gland disease 29.7 TP53 PLAG1 KRT7
33 hemangioma 29.7 TP53 MUC1 KRT7 ACTC1
34 mucinous adenocarcinoma 29.7 VIM TP53 MUC1 KRT7
35 leiomyosarcoma 29.6 VIM TP53 MUC1 HMGA2 ACTC1
36 angiosarcoma 29.6 VIM TP53 MUC1 KRT7
37 breast fibroadenoma 29.6 TP53 KRT14 HMGA2
38 mesenchymal cell neoplasm 29.6 TP53 HMGA2 EWSR1
39 signet ring cell adenocarcinoma 29.6 TP53 MUC1 KRT7 HRAS
40 gastrointestinal stromal tumor 29.6 VIM TP53 SMARCB1 ACTC1
41 syringoma 29.4 VIM PLAG1 MUC1 KRT7 GFAP
42 rhabdomyosarcoma 29.4 VIM TP53 HRAS EWSR1 ACTC1
43 papillary adenocarcinoma 29.4 VIM TP53 MUC1 KRT7 HRAS
44 small cell carcinoma 29.3 TP53 MUC1 KRT7 KRT18
45 thyroid tumor 29.3 TP53 PIK3CA HRAS
46 clear cell adenocarcinoma 29.2 TP53 PIK3CA KRT7
47 spindle cell carcinoma 29.2 VIM MUC1 KRT7 KRT18 KRT14 HRAS
48 spiradenoma 29.2 VIM TP53 MUC1 KRT7 KRT14 ACTC1
49 hepatoblastoma 29.1 TP53 PLAG1 KRT7 KRT18
50 chondrosarcoma, extraskeletal myxoid 29.1 ZNF444 SMARCB1 PLAG1 NR4A3 GFAP EWSR1

Graphical network of the top 20 diseases related to Myoepithelial Carcinoma:



Diseases related to Myoepithelial Carcinoma

Symptoms & Phenotypes for Myoepithelial Carcinoma

GenomeRNAi Phenotypes related to Myoepithelial Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 SMARCB1 TP53

MGI Mouse Phenotypes related to Myoepithelial Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.1 HRAS KRT14 NR4A3 PIK3CA SMARCB1 TP53

Drugs & Therapeutics for Myoepithelial Carcinoma

Drugs for Myoepithelial Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
2 Protein Kinase Inhibitors Phase 2
3 lysine Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study on Inlyta® (Axitinib) in Recurrent and/or Metastatic Salivary Gland Cancers (SGCs) of the Upper Aerodigestive Tract Completed NCT02857712 Phase 2 Axitinib
2 A Phase II, Multicenter Study of the EZH2 Inhibitor Tazemetostat in Adult Subjects With INI1-Negative Tumors or Relapsed/Refractory Synovial Sarcoma Recruiting NCT02601950 Phase 2 Tazemetostat
3 A Phase 1 Study of the EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma Recruiting NCT02601937 Phase 1 Tazemetostat

Search NIH Clinical Center for Myoepithelial Carcinoma

Genetic Tests for Myoepithelial Carcinoma

Anatomical Context for Myoepithelial Carcinoma

MalaCards organs/tissues related to Myoepithelial Carcinoma:

40
Salivary Gland, Breast, Lung, Skin, Tongue, Bone, Trachea

Publications for Myoepithelial Carcinoma

Articles related to Myoepithelial Carcinoma:

(show top 50) (show all 681)
# Title Authors PMID Year
1
Myoepithelial carcinoma of the salivary glands: behavior and management. 61 52
12775221 2003
2
The Immune Microenvironment and Neoantigen Landscape of Aggressive Salivary Gland Carcinomas Differ by Subtype. 61
32060100 2020
3
SMARCB1 (INI-1)-Deficient Adenocarcinoma of the Sinonasal Tract: A Potentially Under-Recognized form of Sinonasal Adenocarcinoma with Occasional Yolk Sac Tumor-Like Features. 61
31468350 2020
4
Reply to "Primary cutaneous biphasic sarcomatoid basal cell carcinoma with myoepithelial carcinoma differentiation. Is it a new variant of sarcomatoid basal cell carcinoma or a collision tumor composed of a myoepithelial carcinoma and an incidental basal cell carcinoma?" 61
32181509 2020
5
"Primary cutaneous biphasic sarcomatoid basal cell carcinoma with myoepithelial carcinoma differentiation": Is it a new variant of sarcomatoid basal cell carcinoma or a collision tumor composed of a myoepithelial carcinoma and an incidental basal cell carcinoma? 61
31995232 2020
6
Cytologic grading of primary malignant salivary gland tumors: A blinded review by an international panel. 61
32267606 2020
7
Primary epithelial-myoepithelial carcinoma of the pituitary gland. 61
31900996 2020
8
"Myoepithelial carcinoma of urinary bladder in a pediatric patient. A case report". 61
32504687 2020
9
Primary Cutaneous Adenomyoepithelioma Ex Spiradenoma With Malignant Histologic Features, Epithelial-Myoepithelial Carcinoma Type: A First Case Report With Molecular Studies. 61
31813296 2020
10
New Insights into Tumor Heterogeneity: A Case of Solid-Oncocytic Epithelial-Myoepithelial Carcinoma of the Parotid Gland Harboring a HRAS and Heterogeneous Terminating ARID1A Mutation. 61
31309433 2020
11
A first case report of clinical response to targeted therapy in a patient with primary myoepithelial carcinoma of the lung harboring EGFR exon 19 deletion. 61
32505185 2020
12
Association between prognosis and complete resection in primary cutaneous myoepithelial carcinoma: two case presentations and literature review. 61
32369232 2020
13
Epithelial-Myoepithelial Carcinoma Of The Base Of Tongue. 61
32487431 2020
14
Clinical outcomes and the role of bronchoscopic intervention in patients with primary pulmonary salivary gland-type tumors. 61
32512274 2020
15
Epithelial-Myoepithelial Carcinoma of the Lacrimal Gland: Case Report of Youngest Patient. 61
32332692 2020
16
Desmoplastic Small Round Cell Tumor of Parotid Gland: A Rare Entity With Diagnostic Challenge. 61
32241209 2020
17
3D printed titanium prosthesis reconstruction following subtotal maxillectomy for myoepithelial carcinoma - a case report. 61
30922711 2020
18
Salivary Duct Carcinoma of the Parotid Gland Originating from an Epithelial-Myoepithelial Carcinoma: Report of a Rare Case. 61
30937832 2020
19
Case of metastatic cutaneous myoepithelial carcinoma lacking severe cytological atypia. 61
31885105 2020
20
A multicentre retrospective clinico-histopathological review of 250 patients after parotidectomy. 61
31375455 2020
21
Epithelial myoepithelial carcinoma of the parotid gland: A rare tumor with oncocytic changes. 61
32031104 2020
22
[A Rare Case of Pulmonary Epithelial-myoepithelial Carcinoma: Case Report and Literature Review]. 61
32093457 2020
23
Fine-needle aspiration cytology of the apocrine variant of epithelial-myoepithelial carcinoma. 61
31433568 2020
24
Bronchoscopic management of a primary endobronchial salivary epithelial-myoepithelial carcinoma: A case report. 61
32435581 2020
25
Epithelial-Myoepithelial Carcinoma of the Palate: Report of a Case and Review of the Literatures. 61
32215030 2020
26
Epithelial-Myoepithelial Carcinoma of the Lacrimal Sac and Literature Review of the Lacrimal System. 61
32341837 2020
27
Epithelial-myoepithelial carcinoma originating from a minor salivary gland in the nasal septum: A case report and literature review. 61
32000457 2020
28
[Reconstruction of orbital floor defect with preserved orbital contents after advanced maxillary sinus cancer resection]. 61
31954385 2020
29
Epithelial-myoepithelial carcinoma on lower lip and microinvasive verrucous carcinoma in vocal cord: Case report. 61
32259043 2020
30
A Rare De Novo Myoepithelial Carcinoma Ex Pleomorphic Adenoma in a Young Woman. 61
32158581 2020
31
SOX10 Immunoexpression in Basaloid Squamous Cell Carcinomas: A Diagnostic Pitfall for Ruling out Salivary Differentiation. 61
30498968 2019
32
Epithelial membrane antigen and DOG1 expression in minor salivary gland tumours. 61
31629156 2019
33
Utility of neck dissection for management of carcinoma of the parotid gland. 61
31564483 2019
34
Primary cutaneous biphasic sarcomatoid basal cell carcinoma with myoepithelial carcinoma differentiation: A new variant. 61
31278765 2019
35
Adult soft tissue myoepithelial carcinoma: treatment outcomes and efficacy of chemotherapy. 61
31879796 2019
36
Apocrine epithelial-myoepithelial carcinoma of the parotid gland with concurrent oncocytic change: a novel variant. 61
31078503 2019
37
[Clinical characteristics and treatment of myoepithelial carcinoma of head and neck]. 61
31914301 2019
38
Epithelial-myoepithelial carcinoma of the breast: A rare type of malignant adenomyoepithelioma. 61
31310415 2019
39
High levels of ANXA2 are characteristic of malignant salivary gland tumors. 61
31325182 2019
40
Primary salivary gland-type tumors of the tracheobronchial tree diagnosed by transbronchial fine needle aspiration: Clinical and cytomorphologic features with histopathologic correlation. 61
31343850 2019
41
Evaluation of Lateral Temporal Bone Resection in Locally Advanced Tumours of the Parotid Gland. 61
31750185 2019
42
Hepatic Myoepithelial Carcinoma in a Dog: Immunohistochemical Comparison With Other Canine Hepatic Carcinomas. 61
31170892 2019
43
Impact of adjuvant therapy on survival in patients with myoepithelial carcinoma: A systematic review and individual patient data analysis of 691 patients. 61
31276988 2019
44
Epithelial Myoepithelial Carcinoma of Parotid Gland. 61
31741932 2019
45
Myoepithelial carcinoma of tibia mimic giant cell tumor: a case report with emphasis on MR features. 61
30868231 2019
46
An Unusual Presentation and Aggressive Course of Metastatic Myoepithelial Carcinoma. 61
31641419 2019
47
[Recurrent maxillary sinus pleomorphic gonadoma into myoepithelial carcinoma: a case report]. 61
31446713 2019
48
A first case report of primary epithelial myoepithelial carcinoma-like renal tumor showing a perivascular pseudorosette-like pattern: Description of morphologic, immunohistochemical, and genetic features. 61
31574838 2019
49
Adenomyoepitheliomas of the Breast Frequently Harbor Recurrent Hotspot Mutations in PIK3-AKT Pathway-related Genes and a Subset Show Genetic Similarity to Salivary Gland Epithelial-Myoepithelial Carcinoma. 61
31094929 2019
50
Diagnostic Significance of HRAS Mutations in Epithelial-Myoepithelial Carcinomas Exhibiting a Broad Histopathologic Spectrum. 61
30994537 2019

Variations for Myoepithelial Carcinoma

Cosmic variations for Myoepithelial Carcinoma:

9 (show top 50) (show all 1086)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM87897883 TP53 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.659A>G p.Y220C 17:7674872-7674872 4
2 COSM87133148 PIK3CA salivary gland,parotid,carcinoma,myoepithelial carcinoma c.3145G>C p.G1049R 3:179234302-179234302 4
3 COSM87135928 PIK3CA salivary gland,parotid,carcinoma,myoepithelial carcinoma c.331A>G p.K111E 3:179199156-179199156 4
4 COSM98832818 KDM5C salivary gland,parotid,carcinoma,myoepithelial carcinoma c.455T>A p.L152* 23:53217863-53217863 4
5 COSM112988925 HRAS salivary gland,parotid,carcinoma,myoepithelial carcinoma c.181C>A p.Q61K 11:533875-533875 4
6 COSM150915108 CTNNB1 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.104T>C p.I35T 3:41224616-41224616 4
7 COSM133535772 AKT1 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.49G>A p.E17K 14:104780214-104780214 4
8 COSM151592898 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.104T>C p.I35T 3:41224616-41224616 4
9 COSM149960989 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.83T>C p.I28T 3:41224616-41224616 4
10 COSM150962667 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.83T>C p.I28T 3:41224616-41224616 4
11 COSM151345966 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.83T>C p.I28T 3:41224616-41224616 4
12 COSM151492854 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.83T>C p.I28T 3:41224616-41224616 4
13 COSM146246972 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.104T>C p.I35T 3:41224616-41224616 4
14 COSM110182063 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.104T>C p.I35T 3:41224616-41224616 4
15 COSM151326946 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.83T>C p.I28T 3:41224616-41224616 4
16 COSM150312692 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.104T>C p.I35T 3:41224616-41224616 4
17 COSM105721394 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.182A>G p.Q61R 11:533874-533874 4
18 COSM102381853 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.104T>C p.I35T 3:41224616-41224616 4
19 COSM89233576 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.49G>A p.E17K 14:104780214-104780214 4
20 COSM145017479 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.542A>G p.Y181C 17:7674872-7674872 4
21 COSM103028523 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.455T>A p.L152* 23:53217863-53217863 4
22 COSM148933502 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.*225G>C p.? 3:179234302-179234302 4
23 COSM102453467 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.104T>C p.I35T 3:41224616-41224616 4
24 COSM150277642 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.104T>C p.I35T 3:41224616-41224616 4
25 COSM144087035 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.182A>G p.Y61C 17:7674872-7674872 4
26 COSM105584865 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.49G>A p.E17K 14:104780214-104780214 4
27 COSM93183448 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.659A>G p.Y220C 17:7674872-7674872 4
28 COSM98760930 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.455T>A p.L152* 23:53217863-53217863 4
29 COSM103842060 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.49G>A p.E17K 14:104780214-104780214 4
30 COSM150815521 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.104T>C p.I35T 3:41224616-41224616 4
31 COSM150455095 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.104T>C p.I35T 3:41224616-41224616 4
32 COSM111758374 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.659A>G p.Y220C 17:7674872-7674872 4
33 COSM101951686 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.181C>A p.Q61K 11:533875-533875 4
34 COSM151309497 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.104T>C p.I35T 3:41224616-41224616 4
35 COSM91331243 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.181C>A p.Q61K 11:533875-533875 4
36 COSM122271391 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.263A>G p.Y88C 17:7674872-7674872 4
37 COSM143156731 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.182A>G p.Y61C 17:7674872-7674872 4
38 COSM144650895 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.542A>G p.Y181C 17:7674872-7674872 4
39 COSM150144859 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.104T>C p.I35T 3:41224616-41224616 4
40 COSM106053037 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.659A>G p.Y220C 17:7674872-7674872 4
41 COSM105620035 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.659A>G p.Y220C 17:7674872-7674872 4
42 COSM98771857 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.332T>A p.L111* 23:53217863-53217863 4
43 COSM105721476 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.181C>A p.Q61K 11:533875-533875 4
44 COSM151828150 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.104T>C p.I35T 3:41224616-41224616 4
45 COSM150092506 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.83T>C p.I28T 3:41224616-41224616 4
46 COSM105890802 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.104T>C p.I35T 3:41224616-41224616 4
47 COSM149483724 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.104T>C p.I35T 3:41224616-41224616 4
48 COSM111889541 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.104T>C p.I35T 3:41224616-41224616 4
49 COSM149388003 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.104T>C p.I35T 3:41224616-41224616 4
50 COSM111039211 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.104T>C p.I35T 3:41224616-41224616 4

Expression for Myoepithelial Carcinoma

Search GEO for disease gene expression data for Myoepithelial Carcinoma.

Pathways for Myoepithelial Carcinoma

GO Terms for Myoepithelial Carcinoma

Cellular components related to Myoepithelial Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.77 ZNF444 VIM TP53 SMARCB1 PLAG1 NR4A3
2 keratin filament GO:0045095 9.33 KRT7 KRT18 KRT14
3 intermediate filament GO:0005882 9.02 VIM KRT7 KRT18 KRT14 GFAP

Biological processes related to Myoepithelial Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.97 TP53 SMARCB1 PLAG1 NR4A3 HRAS HMGA2
2 viral process GO:0016032 9.8 VIM TP53 SMARCB1 KRT7 KRT18
3 negative regulation of apoptotic process GO:0043066 9.77 TP53 NR4A3 KRT18 HMGA2 ACTC1
4 cytokine-mediated signaling pathway GO:0019221 9.73 VIM TP53 PIK3CA MUC1
5 cornification GO:0070268 9.65 KRT7 KRT18 KRT14
6 astrocyte development GO:0014002 9.51 VIM GFAP
7 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.46 TP53 MUC1
8 Bergmann glial cell differentiation GO:0060020 9.32 VIM GFAP
9 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003 9.26 TP53 MUC1
10 positive regulation of histone H4 acetylation GO:0090240 9.16 SMARCB1 MUC1
11 positive regulation of gene expression GO:0010628 9.1 VIM TP53 PLAG1 HRAS HMGA2 ACTC1
12 intermediate filament-based process GO:0045103 8.96 VIM GFAP

Molecular functions related to Myoepithelial Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.43 VIM KRT14 GFAP
2 p53 binding GO:0002039 9.33 TP53 SMARCB1 MUC1
3 cAMP response element binding GO:0035497 9.32 NR4A3 HMGA2
4 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.1 TP53 SMARCB1 PLAG1 NR4A3 MUC1 HMGA2
5 keratin filament binding GO:1990254 8.96 VIM KRT14

Sources for Myoepithelial Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
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43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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