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MCID: MYP001
MIFTS: 38

Myoepithelioma

Categories: Cancer diseases, Skin diseases
Genes Variations Tissues Related diseases Publications Pathways
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Aliases & Classifications for Myoepithelioma

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MalaCards integrated aliases for Myoepithelioma:

Name: Myoepithelioma 12 54 43 15 71
Benign Myoepithelioma 12 71
Malignant Myoepithelioma 71
Myoepithelial Neoplasm 12
Myoepithelial Adenoma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2661
MeSH 43 D009208
NCIt 49 C40392
SNOMED-CT 67 69291002
UMLS 71 C0027070 C0334699 C1947949
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Summaries for Myoepithelioma

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Disease Ontology : 12 A sweat gland benign neoplasm that is composed of outgrowths of myoepithelial cells from a sweat gland.

MalaCards based summary : Myoepithelioma, also known as benign myoepithelioma, is related to breast adenomyoepithelioma and breast myoepithelial neoplasm. An important gene associated with Myoepithelioma is ACTC1 (Actin Alpha Cardiac Muscle 1), and among its related pathways/superpathways are Cytoskeletal Signaling and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. Affiliated tissues include salivary gland, breast and skin, and related phenotypes are cellular and cardiovascular system

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Related Diseases for Myoepithelioma

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Diseases related to Myoepithelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 269)
# Related Disease Score Top Affiliating Genes
1 breast adenomyoepithelioma 32.0 SERPINB5 PLAG1 KRT14
2 breast myoepithelial neoplasm 31.8 SERPINB5 PLAG1 KRT14
3 rare tumor 31.6 EWSR1 ACTC1
4 leiomyoma 30.8 VIM S100A1 ACTC1
5 myopericytoma 30.6 S100B ACTC1
6 epithelioid sarcoma 30.6 VIM SMARCB1 MUC1
7 myoepithelial carcinoma 30.6 ZNF444 VIM SMARCB1 PLAG1 MUC1 KRT18
8 chondromyxoid fibroma 30.4 VIM S100A1 ACTC1
9 fibroma 30.4 VIM S100A1 KRT14 ACTC1
10 chondrosarcoma 30.4 VIM S100B S100A1 MUC1 EWSR1
11 smooth muscle tumor 30.4 VIM S100A1 ACTC1
12 myxoid chondrosarcoma 30.3 SMARCB1 S100B MUC1 EWSR1
13 secretory meningioma 30.3 VIM SMARCB1 MUC1
14 hidradenoma 30.3 ZNF444 VIM MUC1
15 extraosseous chondrosarcoma 30.2 ZNF444 SMARCB1 EWSR1
16 spindle cell sarcoma 30.2 VIM S100B MUC1 ACTC1
17 carcinosarcoma 30.2 VIM S100A1 MUC1 ACTC1
18 fibrous histiocytoma 30.1 VIM S100B EWSR1 ACTC1
19 central epithelioid sarcoma 30.1 VIM SMARCB1 KRT18
20 oncocytoma 30.1 VIM S100A1 MUC1 KRT18 KRT14
21 epithelial-myoepithelial carcinoma 29.9 VIM SMARCB1 PLAG1 KRT14
22 meningioma, radiation-induced 29.8 VIM SMARCB1 S100B MUC1 GFAP
23 neurilemmoma 29.7 VIM SMARCB1 S100B S100A1 MUC1 GFAP
24 parachordoma 29.5 ZNF444 VIM TBXT S100A1 MUC1 GFAP
25 sarcoma, synovial 29.3 VIM SMARCB1 S100B MUC1 KRT14 EWSR1
26 pleomorphic adenoma 29.3 VIM TP63 SERPINB5 S100B S100A1 PLAG1
27 syringoma 29.3 VIM SERPINB5 S100B S100A1 PLAG1 MUC1
28 chordoma 29.3 VIM TBXT SMARCB1 S100B S100A1 MUC1
29 ewing sarcoma 29.3 VIM S100B PTPRC KITLG EWSR1
30 chondrosarcoma, extraskeletal myxoid 29.2 ZNF444 SMARCB1 PLAG1 PBX3 GFAP EWSR1
31 neurofibroma 29.0 VIM S100B S100A1 MUC1 KITLG ACTC1
32 polymorphous low-grade adenocarcinoma 28.9 VIM TP63 SERPINB5 S100B S100A1 MUC1
33 adenoid cystic carcinoma 28.8 VIM TP63 SERPINB5 S100B S100A1 PLAG1
34 sarcoma 28.7 VIM SMARCB1 S100B S100A1 PTPRC MUC1
35 clear cell hidradenoma 11.6
36 breast myoepitheliosis 11.3
37 adenoma 10.7
38 papillary ependymoma 10.6 S100B GFAP
39 malignant giant cell tumor 10.5 S100B ACTC1
40 lymphangiectasis 10.5 VIM ACTC1
41 hydromyelia 10.5 VIM S100B
42 intravascular papillary endothelial hyperplasia 10.5 VIM ACTC1
43 glomangiomyoma 10.5 VIM ACTC1
44 anaplastic ganglioglioma 10.5 GFAP ACTC1
45 bednar tumor 10.5 VIM S100B
46 primary hepatic neuroendocrine carcinoma 10.5 VIM S100B
47 sclerosing perineurioma 10.5 S100B MUC1
48 benign metastasizing leiomyoma 10.5 VIM ACTC1
49 localized hypertrophic neuropathy 10.5 S100B MUC1
50 malignant iris melanoma 10.5 S100B S100A1

Graphical network of the top 20 diseases related to Myoepithelioma:



Diseases related to Myoepithelioma
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Symptoms & Phenotypes for Myoepithelioma

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MGI Mouse Phenotypes related to Myoepithelioma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.17 ACTC1 GFAP KITLG KRT14 PBX3 PTPRC
2 cardiovascular system MP:0005385 10.16 ACTC1 GFAP KITLG PBX3 PTPRC S100A1
3 growth/size/body region MP:0005378 10.1 ACTC1 GFAP KITLG KRT14 KRT18 PBX3
4 homeostasis/metabolism MP:0005376 10.03 ACTC1 GFAP KITLG KRT14 PBX3 PTPRC
5 digestive/alimentary MP:0005381 10.01 GFAP KITLG KRT14 PBX3 PTPRC SMARCB1
6 embryo MP:0005380 9.97 KITLG KRT18 PLAG1 SERPINB5 SMARCB1 TBXT
7 integument MP:0010771 9.76 KITLG KRT14 PBX3 PTPRC S100B SMARCB1
8 mortality/aging MP:0010768 9.73 ACTC1 GFAP KITLG KRT14 KRT18 PBX3
9 normal MP:0002873 9.23 ACTC1 GFAP PTPRC S100A1 S100B SERPINB5
Sources

Drugs & Therapeutics for Myoepithelioma

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Accuracy of Multiparametric Magnetic Resonance Imaging Versus Fine Needle Aspiration Cytology in the Preoperative Work-Up of Parotid Gland Neoplasms Recruiting NCT03849482

Search NIH Clinical Center for Myoepithelioma

Cochrane evidence based reviews: myoepithelioma

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Genetic Tests for Myoepithelioma

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Anatomical Context for Myoepithelioma

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MalaCards organs/tissues related to Myoepithelioma:

40
Salivary Gland, Breast, Skin, Tongue, Bone, Lung, Smooth Muscle
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Publications for Myoepithelioma

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Articles related to Myoepithelioma:

(show top 50) (show all 651)
# Title Authors PMID Year
1
Myoepithelioma with melanocytic colonization (melanocytic myoepithelioma): a case report. 54 61
19515051 2009
2
Giant myoepithelioma of the upper lip. 61 54
16099771 2005
3
Myoepithelioma of the parotid gland initially diagnosed by fine needle aspiration cytology and immunocytochemistry: a case report. 61 54
15717758 2005
4
Malignant myoepithelioma of the salivary gland--an untypical clinical course. 54 61
15619979 2004
5
[Myoepithelial differentiation markers in salivary gland neoplasia]. 61 54
11785118 2001
6
The effect of a reconstituted basement membrane (matrigel) on a human salivary gland myoepithelioma cell line. 54 61
11710645 2001
7
Expression of smooth-muscle actin in cultured cells from human plasmacytoid myoepithelioma. 54 61
9431536 1997
8
[Malignant myoepithelioma associated with in situ and invasive ductal carcinoma. Description of a case and review of the literature]. 61 54
9471611 1997
9
Myoepithelioma: definitions and diagnostic criteria. 61 54
7483010 1995
10
Plasmacytoid monomorphic adenoma of salivary glands. Absence of myogenous differentiation and comparison to spindle cell myoepithelioma. 54 61
8380682 1993
11
Spindle cell squamous carcinoma of the oral region. An immunohistochemical and ultrastructural study on the histogenesis and differential diagnosis with a clinicopathological analysis of six cases. 61 54
1718079 1991
12
Multiple expression of keratins, vimentin, and S-100 protein in pleomorphic salivary adenomas. 61 54
1694334 1990
13
Psammoma Bodies in a Large Myoepithelioma. 61
32049921 2020
14
Cutaneous myoepithelioma of the foot. 61
31769018 2020
15
Myoepithelioma of the Lower Eyelid. 61
31868789 2020
16
Biphasic Feline Mammary Carcinomas Including Carcinoma and Malignant Myoepithelioma. 61
32100640 2020
17
Foot plantar soft tissue malignant myoepithelioma tumor: Case report and review of the literature. 61
32000118 2020
18
Malignant Myoepithelioma of the Parotid Gland in a Rat. 61
32359631 2020
19
Painful Cutaneous Syncytial Myoepithelioma: From Nonspecific Symptoms to Histopathologic Diagnosis. 61
31615626 2020
20
Myoepithelioma-like Hyalinizing Epithelioid Tumors of the Hand With Novel OGT-FOXO3 Fusions. 61
31567281 2020
21
Skull Base Parachordoma/Myoepithelioma. 61
32147599 2020
22
Strain elastography of palatal tumors in conjunction with intraoral ultrasonography, computed tomography, and magnetic resonance imaging: 2 case reports. 61
32206623 2020
23
A mitotically active SMARCB1-deficient myoepithelioma-like tumour of the vulvar region with probable benign behaviour. 61
31889550 2020
24
Cutaneous Syncytial Myoepithelioma: A Nondescript Skin Tumor With Serious Diagnostic Pitfalls. 61
31587595 2020
25
Metachronous Pancreatic and Thyroid Metastases from Primary Soft-Tissue Myoepithelioma in the Clavicular Region: A Case Report of a Long-Term Survivor. 61
31983728 2020
26
Myoepithelioma-like tumor of the vulvar region: a case report in China and review of the literature. 61
31915021 2020
27
A case of cellular variants of Sclerosing epithelioid fibrosarcoma resembling Plasmacytoma/Myeloma: Diagnostic difficulty in the fine needle aspiration. 61
32193142 2020
28
[Clinicopathological features of lung salivary gland-type tumors]. 61
31818065 2019
29
A Case of Myoepithelioma of the Nasal Cavity. 61
31763237 2019
30
Plasmacytoid cells in salivary pleomorphic adenoma: an alternative interpretation of their immunohistochemical characteristics highlights function and capability for epithelial-mesenchymal transition. 61
31400990 2019
31
Cutaneous Syncytial Myoepithelioma Is Characterized by Recurrent EWSR1-PBX3 Fusions. 61
31135487 2019
32
Myoepithelioma of nasal septum: a rare minor salivary gland tumour. 61
31653626 2019
33
Plasmacytoid Myoepithelioma of Palate Heading Toward Malignancy: A Rare Case With Immunohistochemical Analysis. 61
30909738 2019
34
Spindle cell myoepithelioma of the parotid gland. 61
31658801 2019
35
Cystic Myoepithelioma of Parapharyngeal Space. 61
31742043 2019
36
Myoepithelioma-like tumour of the vulvar region. 61
31470996 2019
37
Intracranial Myoepithelioma: A Case Report and Review of Literature. 61
31744974 2019
38
Myoepithelioma of the soft tissue: A systematic review of clinical reports. 61
31085025 2019
39
Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours. 61
31209701 2019
40
Canine Spindle Cell Mammary Tumor: A Retrospective Study of 67 Cases. 61
30857503 2019
41
Basal cell adenoma and myoepithelioma of the parotid gland: patterns of enhancement at two-phase CT in comparison with Warthin tumor. 61
31120425 2019
42
Case of cutaneous myoepithelioma managed with surgical resection without recurrence for 4 years. 61
30672605 2019
43
Characterisation of DOG-1 Expression in Salivary Gland Tumours and Comparison with Myoepithelial Markers. 61
29671211 2019
44
EWSR1-PBX3 gene fusion in cutaneous syncytial myoepithelioma. 61
30834570 2019
45
Utility of smooth muscle actin and CD117 as reliable markers in the diagnosis of salivary gland neoplasms. 61
31516227 2019
46
Misinterpreted Myoepithelial Carcinoma of Salivary Gland: A Challenging and Potentially Significant Pitfall. 61
30789358 2019
47
New fusion sarcomas: histopathology and clinical significance of selected entities. 61
30633925 2019
48
Myoepithelioma-like tumor of the vulvar region showing infiltrative growth and harboring only a few estrogen receptor-positive cells: A case report. 61
30737997 2019
49
Clear cell, giant myoepithelioma of tongue base: a diagnostic and surgical challenge. 61
30665928 2019
50
EWSR1-PBX3 fused myoepithelioma arising in metatarsal bone: Case report and review of the literature. 61
30605259 2019
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Variations for Myoepithelioma

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Copy number variations for Myoepithelioma from CNVD:

7
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 13767 1 1 28000000 Loss Myoepithelioma
2 75376 13 19500000 115169878 Loss Myoepithelioma
3 124183 19 1 6900000 Loss Myoepithelioma
4 127358 19 32400000 35500000 Loss Myoepithelioma
5 195327 5 15000000 18400000 Gain Myoepithelioma
6 247562 9 130300000 141213431 Loss Myoepithelioma
7 249425 9 14200000 33200000 Loss Myoepithelioma
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Expression for Myoepithelioma

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Search GEO for disease gene expression data for Myoepithelioma.
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Pathways for Myoepithelioma

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Pathways related to Myoepithelioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cytoskeletal Signaling 4
12.05 VIM MUC1 KRT18 ACTC1
2
Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers 64
11.38 VIM TP63 TBXT KITLG
3
Neural Stem Cells and Lineage-specific Markers 64
11.23 VIM S100B GFAP
4
Cytoskeleton remodeling Neurofilaments 22
Show member pathways
 10.96 VIM KRT18 KRT14 GFAP
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GO Terms for Myoepithelioma

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Cellular components related to Myoepithelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10.07 VIM TP63 TBXT SERPINB5 S100B S100A1
2 nucleus GO:0005634 9.97 ZNF444 VIM TP63 TBXT SMARCB1 S100B
3 cell periphery GO:0071944 9.13 PTPRC KRT18 KRT14
4 intermediate filament GO:0005882 8.92 VIM KRT18 KRT14 GFAP

Biological processes related to Myoepithelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of glial cell proliferation GO:0060252 9.37 PLAG1 GFAP
2 post-anal tail morphogenesis GO:0036342 9.32 TP63 TBXT
3 astrocyte development GO:0014002 9.26 VIM GFAP
4 Bergmann glial cell differentiation GO:0060020 9.16 VIM GFAP
5 positive regulation of histone H4 acetylation GO:0090240 8.96 SMARCB1 MUC1
6 intermediate filament-based process GO:0045103 8.62 VIM GFAP

Molecular functions related to Myoepithelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.72 TBXT SMARCB1 PLAG1 PBX3 MUC1
2 structural constituent of cytoskeleton GO:0005200 9.43 VIM KRT14 GFAP
3 S100 protein binding GO:0044548 9.16 S100B S100A1
4 p53 binding GO:0002039 9.13 TP63 SMARCB1 MUC1
5 keratin filament binding GO:1990254 8.62 VIM KRT14
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Sources for Myoepithelioma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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