MCID: MYP001
MIFTS: 39

Myoepithelioma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Myoepithelioma

MalaCards integrated aliases for Myoepithelioma:

Name: Myoepithelioma 12 56 45 15 74
Benign Myoepithelioma 12 74
Malignant Myoepithelioma 74
Myoepithelial Neoplasm 12
Myoepithelial Adenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2661
MeSH 45 D009208
NCIt 51 C40392
SNOMED-CT 69 69291002

Summaries for Myoepithelioma

Disease Ontology : 12 A sweat gland neoplasm that is composed_of outgrowths of myoepithelial cells from a sweat gland.

MalaCards based summary : Myoepithelioma, also known as benign myoepithelioma, is related to parachordoma and myopericytoma. An important gene associated with Myoepithelioma is ACTC1 (Actin Alpha Cardiac Muscle 1), and among its related pathways/superpathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include salivary gland, breast and skin, and related phenotypes are cellular and homeostasis/metabolism

Related Diseases for Myoepithelioma

Diseases related to Myoepithelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 180)
# Related Disease Score Top Affiliating Genes
1 parachordoma 30.5 ACTC1 GFAP VIM
2 myopericytoma 30.3 ACTC1 S100B
3 hemangiopericytoma, malignant 30.1 ACTC1 S100B VIM
4 epithelial-myoepithelial carcinoma 30.0 KRT14 SMARCB1
5 epithelioid sarcoma 30.0 SMARCB1 VIM
6 pleomorphic adenoma 29.7 ACTC1 GFAP KRT14 S100B TP63 VIM
7 polymorphous low-grade adenocarcinoma 29.4 ACTC1 S100A1 S100B TP63 VIM
8 chordoma 29.3 GFAP S100A1 S100B SMARCB1 VIM
9 adenoid cystic carcinoma 29.0 ACTC1 KRT14 S100A1 S100B TP63 VIM
10 myoepithelial carcinoma 11.6
11 clear cell hidradenoma 11.4
12 breast adenomyoepithelioma 11.2
13 breast myoepitheliosis 11.2
14 breast myoepithelial neoplasm 11.1
15 adenoma 10.4
16 lymphangiectasis 10.4 ACTC1 VIM
17 glomangiomyoma 10.4 ACTC1 VIM
18 angiolipoma 10.4 ACTC1 VIM
19 intravascular papillary endothelial hyperplasia 10.4 ACTC1 VIM
20 spindle cell lipoma 10.4 ACTC1 VIM
21 perineurioma 10.4 S100B VIM
22 epithelioid leiomyosarcoma 10.4 ACTC1 VIM
23 benign metastasizing leiomyoma 10.4 ACTC1 VIM
24 papillary tumor of the pineal region 10.4 S100A1 VIM
25 adenofibroma 10.4 ACTC1 VIM
26 hydromyelia 10.4 S100B VIM
27 bednar tumor 10.4 S100B VIM
28 primary hepatic neuroendocrine carcinoma 10.4 S100B VIM
29 fibrous meningioma 10.3 S100B VIM
30 eccrine porocarcinoma 10.3 S100B VIM
31 malignant giant cell tumor of soft parts 10.3 ACTC1 S100B
32 malignant giant cell tumor 10.3 ACTC1 S100B
33 perivascular epithelioid cell tumor 10.3 ACTC1 VIM
34 malignant iris melanoma 10.3 S100A1 S100B
35 congenital fibrosarcoma 10.3 ACTC1 VIM
36 primitive neuroectodermal tumor of the cervix uteri 10.3 GFAP VIM
37 monophasic synovial sarcoma 10.3 S100B VIM
38 anaplastic ganglioglioma 10.3 ACTC1 GFAP
39 pseudosarcomatous fibromatosis 10.3 ACTC1 VIM
40 clear cell ependymoma 10.3 GFAP VIM
41 juvenile xanthogranuloma 10.3 S100B VIM
42 fibromatosis 10.3 ACTC1 VIM
43 cutaneous leiomyosarcoma 10.3 ACTC1 GFAP
44 glomus tumor 10.3 ACTC1 VIM
45 pleomorphic liposarcoma 10.3 S100B VIM
46 clear cell meningioma 10.3 GFAP VIM
47 ependymoblastoma 10.3 GFAP VIM
48 astroblastoma 10.3 GFAP VIM
49 ischemic fasciitis 10.3 ACTC1 S100A1
50 amelanotic melanoma 10.3 S100B VIM

Graphical network of the top 20 diseases related to Myoepithelioma:



Diseases related to Myoepithelioma

Symptoms & Phenotypes for Myoepithelioma

MGI Mouse Phenotypes related to Myoepithelioma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.7 ACTC1 GFAP KRT14 S100A1 SMARCB1 TP63
2 homeostasis/metabolism MP:0005376 9.56 ACTC1 GFAP KRT14 S100A1 S100B SMARCB1
3 muscle MP:0005369 9.1 ACTC1 GFAP S100A1 SMARCB1 TP63 VIM

Drugs & Therapeutics for Myoepithelioma

Search Clinical Trials , NIH Clinical Center for Myoepithelioma

Cochrane evidence based reviews: myoepithelioma

Genetic Tests for Myoepithelioma

Anatomical Context for Myoepithelioma

MalaCards organs/tissues related to Myoepithelioma:

42
Salivary Gland, Breast, Skin, Bone, Tongue, Lung, Adipocyte

Publications for Myoepithelioma

Articles related to Myoepithelioma:

(show top 50) (show all 334)
# Title Authors Year
1
EWSR1-PBX3 fused myoepithelioma arising in metatarsal bone: Case report and review of the literature. ( 30605259 )
2019
2
Clear cell, giant myoepithelioma of tongue base: a diagnostic and surgical challenge. ( 30665928 )
2019
3
Case of cutaneous myoepithelioma managed with surgical resection without recurrence for 4 years. ( 30672605 )
2019
4
Myoepithelioma-like tumor of the vulvar region showing infiltrative growth and harboring only a few estrogen receptor-positive cells: A case report. ( 30737997 )
2019
5
EWSR1-PBX3 Gene Fusion in Cutaneous Syncytial Myoepithelioma. ( 30834570 )
2019
6
Plasmacytoid Myoepithelioma of Palate Heading Toward Malignancy: A Rare Case With Immunohistochemical Analysis. ( 30909738 )
2019
7
Myoepithelioma of the lateral abdominal wall: A case report. ( 29979383 )
2018
8
Myoepithelioma of Soft Tissue With Both Squamous and Adipocytic Metaplasia. ( 28796694 )
2018
9
Oral metastasis of renal cell carcinoma mimicking recurrence of excised malignant myoepithelioma: A case report. ( 29896402 )
2018
10
Treatment of an obstructive, recurrent, syncytial myoepithelioma of the trachea with tracheal resection and reconstruction. ( 29728191 )
2018
11
Myoepithelioma of soft tissue and diagnostic pitfall in cytology. ( 29531573 )
2018
12
Case Reports in Oncological Medicine Myoepithelioma: A New Rearrangement Involving the LPP Locus in a Case of Multiple Bone and Soft Tissue Lesions. ( 29992069 )
2018
13
Myoepithelioma occurring in the posterior mediastinum harboring EWSR1 rearrangement: a case report. ( 30053180 )
2018
14
Myoepithelioma of soft tissue in the gluteal region: Diagnostic pitfall in cytology. ( 28694835 )
2017
15
Myoepithelioma of the Soft Palate. ( 29077683 )
2017
16
Myoepithelioma of the Nasal Septum: A Rare Case of Extrasalivary Gland Involvement. ( 28168074 )
2017
17
Myoepithelioma of the Parotid Gland: A Case Report with Review of the Literature and Classic Histopathology. ( 28900549 )
2017
18
Myoepithelioma of the Nasal Septum. ( 28872497 )
2017
19
Myoepithelioma of soft tissue: A cytological-pathological correlation with literature review. ( 28325355 )
2017
20
Plasmacytoid Myoepithelioma of the Hard Palate: Case Report. ( 28827853 )
2017
21
Congenital Myoepithelial Carcinoma of Soft Tissue Associated With Cystic Myoepithelioma. ( 28675958 )
2017
22
Intraosseous myoepithelioma: a rare tumour in the hand. ( 27807178 )
2017
23
Identification of SRF-E2F1 fusion transcript in EWSR-negative myoepithelioma of the soft tissue. ( 28947952 )
2017
24
Cutaneous syncytial myoepithelioma: A recently described neoplasm which may mimic nevoid melanoma and epithelioid sarcoma. ( 28708250 )
2017
25
Myoepithelioma of the upper lip. ( 30895031 )
2017
26
Myoepithelioma of the parotid gland with extensive adipocytic metaplasia: Report of a case with intriguing aspects on fine needle aspiration and p63 immunohistochemical expression. ( 27474346 )
2016
27
Dramatic Response to Carboplatin, Paclitaxel, and Radiation in a Patient With Malignant Myoepithelioma of the Breast. ( 27473043 )
2016
28
A case report of spindle cell myoepithelioma with extensive lipomatous metaplasia and thick collagen bundles in the submandibular gland. ( 27307392 )
2016
29
Cystic malignant myoepithelioma of the mons pubis. ( 27480364 )
2016
30
Myoepithelioma of Soft Tissues: A Single Institution Retrospective Case Series. ( 27139621 )
2016
31
Spontaneous malignant myoepithelioma of the maxillary gland in a young adult male BALB/c F1 hybrid mouse. ( 27182115 )
2016
32
Malignant myoepithelioma of the breast: A case report and review of the literature. ( 27123270 )
2016
33
Myoepithelioma-like Tumor of the Vulvar Region Presenting as a Nonmyxoid Spindle-Cell Neoplasm: A Potential Histologic Mimicker of Solitary Fibrous Tumor. ( 26959696 )
2016
34
Cutaneous syncytial myoepithelioma:: Clinico-pathological features and differential diagnosis. ( 27502466 )
2016
35
Primary intra-osseous myoepithelioma of phalanx mimicking an enchondroma. ( 27524490 )
2016
36
Myoepithelioma of soft tissue in the knee: A case report of an unusual location. ( 27166063 )
2016
37
Voluminous Myoepithelioma of the Minor Salivary Glands Involving the Base of the Tongue. ( 27034872 )
2016
38
Malignant Myoepithelioma of the Breast Clinically and Histologically Masquerading as Angiosarcoma: Cytological Findings and Review of the Literature. ( 27498194 )
2016
39
Fine-needle aspiration of soft tissue myoepithelioma. ( 26644362 )
2016
40
Plasmacytoid Myoepithelioma of the Hard Palate in a Child - A Rare Case Report. ( 26557526 )
2015
41
Aggressive primary malignant myoepithelioma of the maxillary sinus. ( 26905165 )
2015
42
Bony myoepithelioma: a rare condition presenting in the hand. ( 26307141 )
2015
43
Myoepithelioma. ( 26538968 )
2015
44
A large mediastinal benign myoepithelioma effacing the entire hemithorax: case report with literature review. ( 26170201 )
2015
45
Myoepithelioma-like Tumors of the Vulvar Region: A Distinctive Group of SMARCB1-deficient Neoplasms. ( 26171919 )
2015
46
Pleomorphic Adenoma With Prominent Clear Cell Myoepithelioma Component of the Lacrimal Gland. ( 25603534 )
2015
47
MRI and CT imaging characteristics of myoepithelioma of the parotid gland. ( 26508793 )
2015
48
Cutaneous syncytial myoepithelioma: A case report with emphasis on the differential diagnosis of problematic dermal tumors. ( 26137055 )
2015
49
Enigma of myoepithelioma at the base of tongue: A rare case report and review of literature. ( 26881649 )
2015
50
A case of myoepithelioma mimicking a parotid cyst. ( 25606835 )
2015

Variations for Myoepithelioma

Copy number variations for Myoepithelioma from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 13767 1 1 28000000 Loss Myoepithelioma
2 75376 13 19500000 115169878 Loss Myoepithelioma
3 124183 19 1 6900000 Loss Myoepithelioma
4 127358 19 32400000 35500000 Loss Myoepithelioma
5 195327 5 15000000 18400000 Gain Myoepithelioma
6 247562 9 130300000 141213431 Loss Myoepithelioma
7 249425 9 14200000 33200000 Loss Myoepithelioma

Expression for Myoepithelioma

Search GEO for disease gene expression data for Myoepithelioma.

Pathways for Myoepithelioma

Pathways related to Myoepithelioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.03 GFAP S100B VIM
2
Show member pathways
10.96 GFAP KRT14 KRT18 VIM

GO Terms for Myoepithelioma

Cellular components related to Myoepithelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.61 ACTC1 EWSR1 GFAP KRT14 KRT18 S100A1
2 I band GO:0031674 9.16 ACTC1 S100A1
3 intermediate filament GO:0005882 8.92 GFAP KRT14 KRT18 VIM

Biological processes related to Myoepithelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 long-term synaptic potentiation GO:0060291 9.37 GFAP S100B
2 muscle filament sliding GO:0030049 9.32 ACTC1 VIM
3 intermediate filament organization GO:0045109 9.26 GFAP VIM
4 astrocyte development GO:0014002 9.16 GFAP VIM
5 Bergmann glial cell differentiation GO:0060020 8.96 GFAP VIM
6 intermediate filament-based process GO:0045103 8.62 GFAP VIM

Molecular functions related to Myoepithelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.5 GFAP KRT18 VIM
2 structural constituent of cytoskeleton GO:0005200 9.33 GFAP KRT14 VIM
3 S100 protein binding GO:0044548 9.26 S100A1 S100B
4 identical protein binding GO:0042802 9.1 EWSR1 GFAP S100A1 S100B TP63 VIM
5 keratin filament binding GO:1990254 8.96 KRT14 VIM

Sources for Myoepithelioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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