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MCID: MYP001
MIFTS: 36

Myoepithelioma

Categories: Cancer diseases, Skin diseases
Genes Variations Tissues Related diseases Publications Pathways
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Aliases & Classifications for Myoepithelioma

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MalaCards integrated aliases for Myoepithelioma:

Name: Myoepithelioma 12 55 44 15 72
Benign Myoepithelioma 12 72
Malignant Myoepithelioma 72
Myoepithelial Neoplasm 12
Myoepithelial Adenoma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2661
MeSH 44 D009208
NCIt 50 C40392
SNOMED-CT 68 69291002
UMLS 72 C0027070 C0334699 C1947949
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Summaries for Myoepithelioma

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Disease Ontology : 12 A sweat gland neoplasm that is composed of outgrowths of myoepithelial cells from a sweat gland.

MalaCards based summary : Myoepithelioma, also known as benign myoepithelioma, is related to breast adenomyoepithelioma and breast myoepithelial neoplasm. An important gene associated with Myoepithelioma is ACTC1 (Actin Alpha Cardiac Muscle 1), and among its related pathways/superpathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include salivary gland, breast and skin, and related phenotypes are behavior/neurological and cellular

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Related Diseases for Myoepithelioma

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Diseases related to Myoepithelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 226)
# Related Disease Score Top Affiliating Genes
1 breast adenomyoepithelioma 32.3 SERPINB5 KRT14
2 breast myoepithelial neoplasm 32.2 SERPINB5 KRT14
3 parachordoma 31.0 VIM GFAP ACTC1
4 leiomyoma 30.8 VIM S100A1 ACTC1
5 myopericytoma 30.7 S100B ACTC1
6 perivascular epithelioid cell tumor 30.7 VIM ACTC1
7 myxoid chondrosarcoma 30.7 S100B EWSR1
8 smooth muscle tumor 30.5 VIM ACTC1
9 dermoid cyst 30.5 VIM TP63
10 chondromyxoid fibroma 30.4 VIM S100A1 ACTC1
11 spindle cell sarcoma 30.4 VIM S100B ACTC1
12 meningioma, radiation-induced 30.3 VIM S100B GFAP
13 extraosseous chondrosarcoma 30.0 SMARCB1 EWSR1
14 mesenchymal cell neoplasm 30.0 SMARCB1 EWSR1
15 cellular schwannoma 29.9 S100B S100A1
16 epithelioid sarcoma 29.7 VIM SMARCB1
17 epithelial-myoepithelial carcinoma 29.7 SMARCB1 KRT14
18 neurilemmoma 29.5 VIM SMARCB1 S100B GFAP
19 syringoma 29.4 VIM TP63 SERPINB5 S100B GFAP
20 chondrosarcoma, extraskeletal myxoid 29.4 SMARCB1 EWSR1
21 ewing sarcoma 29.3 VIM S100B S100A1 GFAP EWSR1
22 pleomorphic adenoma 29.3 VIM TP63 SERPINB5 S100B KRT14 GFAP
23 chordoma 29.1 VIM SMARCB1 S100B S100A1 GFAP
24 polymorphous low-grade adenocarcinoma 28.6 VIM TP63 SERPINB5 S100B S100A1 ACTC1
25 adenoid cystic carcinoma 28.5 VIM TP63 SERPINB5 S100B S100A1 KRT14
26 myoepithelial carcinoma 11.7
27 clear cell hidradenoma 11.5
28 breast myoepitheliosis 11.3
29 adenoma 10.8
30 lymphangiectasis 10.7 VIM ACTC1
31 glomangiomyoma 10.7 VIM ACTC1
32 intravascular papillary endothelial hyperplasia 10.7 VIM ACTC1
33 angiolipoma 10.7 VIM ACTC1
34 perineurioma 10.7 VIM S100B
35 spindle cell lipoma 10.7 VIM ACTC1
36 epithelioid leiomyosarcoma 10.6 VIM ACTC1
37 benign metastasizing leiomyoma 10.6 VIM ACTC1
38 rare tumor 10.6
39 papillary tumor of the pineal region 10.6 VIM S100A1
40 hydromyelia 10.6 VIM S100B
41 bednar tumor 10.6 VIM S100B
42 adenofibroma 10.6 VIM ACTC1
43 primary hepatic neuroendocrine carcinoma 10.6 VIM S100B
44 fibrous meningioma 10.6 VIM S100B
45 malignant giant cell tumor 10.6 S100B ACTC1
46 malignant giant cell tumor of soft parts 10.6 S100B ACTC1
47 eccrine porocarcinoma 10.6 VIM S100B
48 primitive neuroectodermal tumor of the cervix uteri 10.6 VIM GFAP
49 malignant iris melanoma 10.6 S100B S100A1
50 anaplastic ganglioglioma 10.6 GFAP ACTC1

Graphical network of the top 20 diseases related to Myoepithelioma:



Diseases related to Myoepithelioma
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Symptoms & Phenotypes for Myoepithelioma

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MGI Mouse Phenotypes related to Myoepithelioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.87 GFAP S100A1 S100B SERPINB5 SMARCB1 TP63
2 cellular MP:0005384 9.86 ACTC1 GFAP KRT14 S100A1 SERPINB5 SMARCB1
3 homeostasis/metabolism MP:0005376 9.76 ACTC1 GFAP KRT14 S100A1 S100B SMARCB1
4 muscle MP:0005369 9.43 ACTC1 GFAP S100A1 SMARCB1 TP63 VIM
5 normal MP:0002873 9.1 ACTC1 GFAP S100A1 S100B SERPINB5 TP63
Sources

Drugs & Therapeutics for Myoepithelioma

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Accuracy of Multiparametric Magnetic Resonance Imaging Versus Fine Needle Aspiration Cytology in the Preoperative Work-Up of Parotid Gland Neoplasms Recruiting NCT03849482

Search NIH Clinical Center for Myoepithelioma

Cochrane evidence based reviews: myoepithelioma

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Genetic Tests for Myoepithelioma

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Anatomical Context for Myoepithelioma

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MalaCards organs/tissues related to Myoepithelioma:

41
Salivary Gland, Breast, Skin, Tongue, Bone, Lung, Adipocyte
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Publications for Myoepithelioma

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Articles related to Myoepithelioma:

(show top 50) (show all 625)
# Title Authors PMID Year
1
Myoepithelioma with melanocytic colonization (melanocytic myoepithelioma): a case report. 9 38
19515051 2009
2
Giant myoepithelioma of the upper lip. 9 38
16099771 2005
3
Myoepithelioma of the parotid gland initially diagnosed by fine needle aspiration cytology and immunocytochemistry: a case report. 9 38
15717758 2005
4
Malignant myoepithelioma of the salivary gland--an untypical clinical course. 9 38
15619979 2004
5
[Myoepithelial differentiation markers in salivary gland neoplasia]. 9 38
11785118 2001
6
The effect of a reconstituted basement membrane (matrigel) on a human salivary gland myoepithelioma cell line. 9 38
11710645 2001
7
Expression of smooth-muscle actin in cultured cells from human plasmacytoid myoepithelioma. 9 38
9431536 1997
8
[Malignant myoepithelioma associated with in situ and invasive ductal carcinoma. Description of a case and review of the literature]. 9 38
9471611 1997
9
Myoepithelioma: definitions and diagnostic criteria. 9 38
7483010 1995
10
Plasmacytoid monomorphic adenoma of salivary glands. Absence of myogenous differentiation and comparison to spindle cell myoepithelioma. 9 38
8380682 1993
11
Spindle cell squamous carcinoma of the oral region. An immunohistochemical and ultrastructural study on the histogenesis and differential diagnosis with a clinicopathological analysis of six cases. 9 38
1718079 1991
12
Multiple expression of keratins, vimentin, and S-100 protein in pleomorphic salivary adenomas. 9 38
1694334 1990
13
Myoepithelioma of the soft tissue: A systematic review of clinical reports. 38
31085025 2019
14
Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours. 38
31209701 2019
15
Canine Spindle Cell Mammary Tumor: A Retrospective Study of 67 Cases. 38
30857503 2019
16
Basal cell adenoma and myoepithelioma of the parotid gland: patterns of enhancement at two-phase CT in comparison with Warthin tumor. 38
31120425 2019
17
Case of cutaneous myoepithelioma managed with surgical resection without recurrence for 4 years. 38
30672605 2019
18
Characterisation of DOG-1 Expression in Salivary Gland Tumours and Comparison with Myoepithelial Markers. 38
29671211 2019
19
EWSR1-PBX3 gene fusion in cutaneous syncytial myoepithelioma. 38
30834570 2019
20
Cutaneous Syncytial Myoepithelioma is Characterized by Recurrent EWSR1-PBX3 Fusions. 38
31135487 2019
21
Misinterpreted Myoepithelial Carcinoma of Salivary Gland: A Challenging and Potentially Significant Pitfall. 38
30789358 2019
22
New fusion sarcomas: histopathology and clinical significance of selected entities. 38
30633925 2019
23
Plasmacytoid Myoepithelioma of Palate Heading Toward Malignancy: A Rare Case With Immunohistochemical Analysis. 38
30909738 2019
24
Myoepithelioma-like tumor of the vulvar region showing infiltrative growth and harboring only a few estrogen receptor-positive cells: A case report. 38
30737997 2019
25
Plasmacytoid cells in salivary pleomorphic adenoma: an alternative interpretation of their immunohistochemical characteristics highlights function and capability for epithelial-mesenchymal transition. 38
31400990 2019
26
EWSR1-PBX3 fused myoepithelioma arising in metatarsal bone: Case report and review of the literature. 38
30605259 2019
27
Clear cell, giant myoepithelioma of tongue base: a diagnostic and surgical challenge. 38
30665928 2019
28
[Primary malignant myoepithelioma of the humerus: a case report and literature review]. 38
30605987 2018
29
Hierarchical Cluster Analysis of Cytokeratins and Stem Cell Expression Profiles of Canine Cutaneous Epithelial Tumors. 38
30071783 2018
30
[Myxoid variant of angiomatoid fibrous histiocytoma: a clinicopathologic analysis of 3 cases]. 38
30220125 2018
31
Myoepithelioma occurring in the posterior mediastinum harboring EWSR1 rearrangement: a case report. 38
30053180 2018
32
[Clinicopathologic characterization of malignant mixed tumor of the skin accompanied by eccrine porocarcinoma]. 38
29996320 2018
33
Oral metastasis of renal cell carcinoma mimicking recurrence of excised malignant myoepithelioma: A case report. 38
29896402 2018
34
Myoepithelioma of the lateral abdominal wall: A case report. 38
29979383 2018
35
Treatment of an obstructive, recurrent, syncytial myoepithelioma of the trachea with tracheal resection and reconstruction. 38
29728191 2018
36
Extra-axial chordoma: a clinicopathologic analysis of six cases. 38
29560513 2018
37
INSM1 expression and its diagnostic significance in extraskeletal myxoid chondrosarcoma. 38
29327709 2018
38
Myoepithelioma of the Soft Palate. 38
29077683 2018
39
Novel interleukin-33 and its soluble ST2 receptor as potential serum biomarkers in parotid gland tumors. 38
29763370 2018
40
Myoepithelioma of Soft Tissues: A Single Institution Retrospective Case Series. 38
27139621 2018
41
Congenital Myoepithelial Carcinoma of Soft Tissue Associated With Cystic Myoepithelioma. 38
28675958 2018
42
Myoepithelioma of Soft Tissue With Both Squamous and Adipocytic Metaplasia. 38
28796694 2018
43
Ectomesenchymal chondromyxoid tumor: a comprehensive updated review of the literature and case report. 38
29491357 2018
44
Basal Cell Carcinoma with Myoepithelial Differentiation: Case Report and Literature Review. 38
29560294 2018
45
Case Reports in Oncological Medicine Myoepithelioma: A New Rearrangement Involving the LPP Locus in a Case of Multiple Bone and Soft Tissue Lesions. 38
29992069 2018
46
Myoepithelial carcinoma of the parotid gland: A case of adequate fine-needle aspiration cytology specimens rendering a conclusive diagnosis possible. 38
29899989 2018
47
Myoepithelioma of soft tissue and diagnostic pitfall in cytology. 38
29531573 2018
48
Cutaneous syncytial myoepithelioma: A recently described neoplasm which may mimic nevoid melanoma and epithelioid sarcoma. 38
28708250 2017
49
Myoepithelioma of the Nasal Septum. 38
28872497 2017
50
HMGA2 is a specific immunohistochemical marker for pleomorphic adenoma and carcinoma ex-pleomorphic adenoma. 38
28463429 2017
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Variations for Myoepithelioma

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Copy number variations for Myoepithelioma from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 13767 1 1 28000000 Loss Myoepithelioma
2 75376 13 19500000 115169878 Loss Myoepithelioma
3 124183 19 1 6900000 Loss Myoepithelioma
4 127358 19 32400000 35500000 Loss Myoepithelioma
5 195327 5 15000000 18400000 Gain Myoepithelioma
6 247562 9 130300000 141213431 Loss Myoepithelioma
7 249425 9 14200000 33200000 Loss Myoepithelioma
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Expression for Myoepithelioma

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Search GEO for disease gene expression data for Myoepithelioma.
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Pathways for Myoepithelioma

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Pathways related to Myoepithelioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.03 VIM S100B GFAP
2
Cytoskeleton remodeling Neurofilaments 22
Show member pathways
 10.96 VIM KRT18 KRT14 GFAP
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GO Terms for Myoepithelioma

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Cellular components related to Myoepithelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.65 VIM TP63 SERPINB5 S100B S100A1 KRT18
2 I band GO:0031674 9.16 S100A1 ACTC1
3 intermediate filament GO:0005882 8.92 VIM KRT18 KRT14 GFAP

Biological processes related to Myoepithelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 9.32 VIM ACTC1
2 intermediate filament organization GO:0045109 9.26 VIM GFAP
3 astrocyte development GO:0014002 9.16 VIM GFAP
4 Bergmann glial cell differentiation GO:0060020 8.96 VIM GFAP
5 intermediate filament-based process GO:0045103 8.62 VIM GFAP

Molecular functions related to Myoepithelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.5 VIM KRT18 GFAP
2 structural constituent of cytoskeleton GO:0005200 9.33 VIM KRT14 GFAP
3 S100 protein binding GO:0044548 9.26 S100B S100A1
4 identical protein binding GO:0042802 9.1 VIM TP63 S100B S100A1 GFAP EWSR1
5 keratin filament binding GO:1990254 8.96 VIM KRT14
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Sources for Myoepithelioma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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