MCID: MYP001
MIFTS: 47

Myoepithelioma

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Skin diseases

Aliases & Classifications for Myoepithelioma

MalaCards integrated aliases for Myoepithelioma:

Name: Myoepithelioma 12 55 44 15 73
Myoepithelial Carcinoma 12 53 15
Malignant Myoepithelioma 53 73
Benign Myoepithelioma 12 73
Myoepithelioma Carcinoma 53
Myoepithelial Neoplasm 12
Myoepithelial Adenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2661 DOID:4838
MeSH 44 D009208
NCIt 50 C40392 C7596
SNOMED-CT 68 69291002 24292006

Summaries for Myoepithelioma

NIH Rare Diseases : 53 Myoepithelial carcinoma is a rare malignant (cancerous) tumor that usually occurs in the salivary glands in the mouth, but can also occur in skin and soft tissues. Approximately 66% of these tumors occur in a part of the salivary gland, known as the parotid gland. The average age of diagnosis is 55 years. Symptoms of myoepithelial carcinoma usually begin with a painless mass. Other symptoms vary depending on the site of the tumor and may include: hoarseness, nasal blockage, bleeding from the nose, pain, headaches, and facial weakness and paralysis. Treatment depends on the location and stage of the tumor. Treatment options may include surgery to remove the affected tissues, radiation therapy, and chemotherapy.

MalaCards based summary : Myoepithelioma, also known as myoepithelial carcinoma, is related to breast adenomyoepithelioma and breast myoepithelial neoplasm. An important gene associated with Myoepithelioma is KRT14 (Keratin 14), and among its related pathways/superpathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include salivary gland, breast and skin, and related phenotypes are cellular and growth/size/body region

Disease Ontology : 12 A sweat gland neoplasm that is composed_of outgrowths of myoepithelial cells from a sweat gland.

Related Diseases for Myoepithelioma

Diseases related to Myoepithelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 202)
# Related Disease Score Top Affiliating Genes
1 breast adenomyoepithelioma 31.9 KRT14 SERPINB5
2 breast myoepithelial neoplasm 31.8 KRT14 SERPINB5
3 parachordoma 30.4 ACTC1 GFAP VIM
4 myopericytoma 30.2 ACTC1 S100B
5 hemangiopericytoma, malignant 30.1 ACTC1 S100B VIM
6 spindle cell sarcoma 30.0 ACTC1 S100B VIM
7 pleomorphic adenoma 29.9 ACTC1 GFAP KRT14 S100B SERPINB5 TP63
8 epithelial-myoepithelial carcinoma 29.9 KRT14 SMARCB1
9 chondrosarcoma, extraskeletal myxoid 29.5 EWSR1 SMARCB1
10 chordoma 29.5 GFAP S100A1 S100B SMARCB1 VIM
11 rhabdomyosarcoma 29.5 ACTC1 EWSR1 PTPRC VIM
12 polymorphous low-grade adenocarcinoma 29.4 ACTC1 S100A1 S100B SERPINB5 TP63 VIM
13 adenoid cystic carcinoma 29.2 ACTC1 KRT14 S100A1 S100B SERPINB5 TP63
14 clear cell hidradenoma 11.4
15 breast myoepitheliosis 11.2
16 adenoma 10.4
17 pleomorphic adenoma carcinoma 10.3
18 lymphangiectasis 10.3 ACTC1 VIM
19 perineurioma 10.3 S100B VIM
20 glomangiomyoma 10.3 ACTC1 VIM
21 angiolipoma 10.3 ACTC1 VIM
22 intravascular papillary endothelial hyperplasia 10.3 ACTC1 VIM
23 malignant giant cell tumor 10.3 ACTC1 S100B
24 spindle cell lipoma 10.3 ACTC1 VIM
25 epithelioid leiomyosarcoma 10.3 ACTC1 VIM
26 benign metastasizing leiomyoma 10.3 ACTC1 VIM
27 papillary tumor of the pineal region 10.3 S100A1 VIM
28 hydromyelia 10.3 S100B VIM
29 adenofibroma 10.3 ACTC1 VIM
30 bednar tumor 10.3 S100B VIM
31 primary hepatic neuroendocrine carcinoma 10.3 S100B VIM
32 fibrous meningioma 10.3 S100B VIM
33 eccrine porocarcinoma 10.3 S100B VIM
34 malignant iris melanoma 10.3 S100A1 S100B
35 anaplastic ganglioglioma 10.3 ACTC1 GFAP
36 monophasic synovial sarcoma 10.2 S100B VIM
37 clear cell ependymoma 10.2 GFAP VIM
38 perivascular epithelioid cell tumor 10.2 ACTC1 VIM
39 juvenile xanthogranuloma 10.2 S100B VIM
40 congenital fibrosarcoma 10.2 ACTC1 VIM
41 clear cell meningioma 10.2 GFAP VIM
42 fasciitis 10.2 ACTC1 VIM
43 ependymoblastoma 10.2 GFAP VIM
44 astroblastoma 10.2 GFAP VIM
45 pleomorphic liposarcoma 10.2 S100B VIM
46 intracranial cysts 10.2 GFAP S100B
47 melanotic neuroectodermal tumor 10.2 GFAP VIM
48 medulloepithelioma 10.2 GFAP VIM
49 gemistocytic astrocytoma 10.2 GFAP S100B
50 amelanotic melanoma 10.2 S100B VIM

Graphical network of the top 20 diseases related to Myoepithelioma:



Diseases related to Myoepithelioma

Symptoms & Phenotypes for Myoepithelioma

MGI Mouse Phenotypes related to Myoepithelioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 ACTC1 GFAP KRT14 PTPRC S100A1 SERPINB5
2 growth/size/body region MP:0005378 9.92 ACTC1 GFAP KRT14 KRT18 PTPRC SERPINB5
3 homeostasis/metabolism MP:0005376 9.91 ACTC1 GFAP KRT14 PTPRC S100A1 S100B
4 mortality/aging MP:0010768 9.81 ACTC1 GFAP KRT14 KRT18 PTPRC SERPINB5
5 muscle MP:0005369 9.43 ACTC1 GFAP S100A1 SMARCB1 TP63 VIM
6 normal MP:0002873 9.17 ACTC1 GFAP PTPRC S100A1 S100B SERPINB5

Drugs & Therapeutics for Myoepithelioma

Search Clinical Trials , NIH Clinical Center for Myoepithelioma

Cochrane evidence based reviews: myoepithelioma

Genetic Tests for Myoepithelioma

Anatomical Context for Myoepithelioma

MalaCards organs/tissues related to Myoepithelioma:

41
Salivary Gland, Breast, Skin, Lung, Tongue, Bone, Brain

Publications for Myoepithelioma

Articles related to Myoepithelioma:

(show top 50) (show all 687)
# Title Authors Year
1
Myoepithelioma of the lateral abdominal wall: A case report. ( 29979383 )
2018
2
Sinonasal epithelial-myoepithelial carcinoma: Report of a novel subsite and review of the literature. ( 29977654 )
2018
3
Myoepithelioma of Soft Tissue With Both Squamous and Adipocytic Metaplasia. ( 28796694 )
2018
4
Oral metastasis of renal cell carcinoma mimicking recurrence of excised malignant myoepithelioma: A case report. ( 29896402 )
2018
5
Treatment of an obstructive, recurrent, syncytial myoepithelioma of the trachea with tracheal resection and reconstruction. ( 29728191 )
2018
6
Lacrimal myoepithelial carcinoma ex recurrent pleomorphic adenoma: A clinicopathological report and review of the literature. ( 29387416 )
2018
7
The So-Called Aggressive Digital Papillary Adenocarcinoma Is Epithelial-Myoepithelial Carcinoma. ( 29384814 )
2018
8
Myoepithelioma of soft tissue and diagnostic pitfall in cytology. ( 29531573 )
2018
9
High-grade transformation/dedifferentiation of an adenoid cystic carcinoma of the minor salivary gland to myoepithelial carcinoma. ( 29287310 )
2018
10
MYB Translocation Status in Salivary Gland Epithelial-Myoepithelial Carcinoma: Evaluation of Classic, Variant, and Hybrid Forms. ( 29135517 )
2018
11
Metaplastic breast carcinoma composed of epithelial-myoepithelial carcinoma and squamous cell carcinoma: A case report. ( 29642184 )
2018
12
Epithelial-myoepithelial carcinoma of the lung: a case report. ( 29987577 )
2018
13
Epithelial-Myoepithelial Carcinoma Presenting as a Pseudo Veno-Lymphatic Malformation. ( 30080758 )
2018
14
Epithelial-myoepithelial carcinoma: a population-based survival analysis. ( 30127663 )
2018
15
Primary epithelial-myoepithelial carcinoma of the lung with cavitary lesion: A case report. ( 30155254 )
2018
16
Dedifferentiation of oncocytic epithelial-myoepithelial carcinoma to mucoepidermoid carcinoma in parotid gland: A rare case report. ( 30303150 )
2018
17
Epithelial-Myoepithelial Carcinoma in a Canine Salivary Gland. ( 30502796 )
2018
18
Myoepithelial carcinoma or epithelioid sarcoma - A rare diagnosis with poor prognosis. A case report and review of literature. ( 30053614 )
2018
19
Case Reports in Oncological Medicine Myoepithelioma: A New Rearrangement Involving the LPP Locus in a Case of Multiple Bone and Soft Tissue Lesions. ( 29992069 )
2018
20
Myoepithelioma occurring in the posterior mediastinum harboring EWSR1 rearrangement: a case report. ( 30053180 )
2018
21
Neoadjuvant radiation therapy for the management of myoepithelial carcinoma of the upper extremity. ( 29023697 )
2018
22
Malignant Ewing-Like Neoplasm With an EWSR1-KLF15 Fusion: At the Crossroads of a Myoepithelial Carcinoma and a Ewing-Like Sarcoma. A Case Report With Treatment Options. ( 29390927 )
2018
23
Incidental Detection of Synchronous Lung Melanoma on 18F-FDG PET/CT in a Patient With Parotid Gland Myoepithelial Carcinoma. ( 29401144 )
2018
24
Primary pulmonary myoepithelial carcinoma in a young woman: A case report and review of literature. ( 29489660 )
2018
25
Myoepithelial carcinoma of the nasopharynx: Rare case report with clinicopathologic and immunohistochemical features review of literature. ( 29573095 )
2018
26
Report of a unique case of myoepithelial carcinoma of left parotid gland with metachronous bilateral cavernous sinus metastasis. ( 29699873 )
2018
27
Myoepithelial carcinoma of the parotid gland: A case of adequate fine-needle aspiration cytology specimens rendering a conclusive diagnosis possible. ( 29899989 )
2018
28
Metastasis of malignant myoepithelial carcinoma to the brain. ( 30021731 )
2018
29
Diagnostic pitfall: primary myoepithelial carcinoma of the lacrimal gland, case report and literature review. ( 30123086 )
2018
30
Clear cell myoepithelial carcinoma involving vestibule and alveolus: A rare case report with review of literature. ( 30158779 )
2018
31
High-grade myoepithelial carcinoma can show histologically undifferentiated/anaplastic features. ( 30236544 )
2018
32
A Rare Case of an Intracardiac Myoepithelial Carcinoma in an Infant. ( 30531598 )
2018
33
Myoepithelioma of soft tissue in the gluteal region: Diagnostic pitfall in cytology. ( 28694835 )
2017
34
Epithelial-myoepithelial carcinoma with high-grade transformation of parotid gland: A case report and literature review. ( 29245272 )
2017
35
Myoepithelioma of the Soft Palate. ( 29077683 )
2017
36
Myoepithelial carcinoma with RB1 mutation: remarkable chemosensitivity to carcinoma of unknown origin therapy. ( 28390395 )
2017
37
Clear Cell Myoepithelial Carcinoma of the Upper Lip -A Rare Case Report. ( 28272678 )
2017
38
Case of myoepithelial carcinoma on scalp. ( 28464327 )
2017
39
Myoepithelial Carcinoma of the Paracecal Mesentery: Aggressive Behavior of a Rare Neoplasm at an Unusual Anatomic Site. ( 28458787 )
2017
40
Epithelial-Myoepithelial Carcinoma of the Base of Tongue with Possible Lung Metastases. ( 29085691 )
2017
41
Myoepithelioma of the Nasal Septum: A Rare Case of Extrasalivary Gland Involvement. ( 28168074 )
2017
42
Myoepithelioma of the Parotid Gland: A Case Report with Review of the Literature and Classic Histopathology. ( 28900549 )
2017
43
Myoepithelioma of the Nasal Septum. ( 28872497 )
2017
44
Endobronchial epithelial-myoepithelial carcinoma of the lung. ( 29196470 )
2017
45
Primary myoepithelial carcinoma of the lung and (18)F-FDG PET/CT. ( 28610871 )
2017
46
Myoepithelioma of soft tissue: A cytological-pathological correlation with literature review. ( 28325355 )
2017
47
Salivary epithelial-myoepithelial carcinoma: clinical, morphological and molecular features. ( 28635988 )
2017
48
Myoepithelial Carcinoma of the Thigh after Lipoma Excision. ( 28822356 )
2017
49
Epithelial Myoepithelial Carcinoma of the Nasal Cavity: Clinical, Histopathological, and Immunohistochemical Distinction of a Case Report. ( 29237344 )
2017
50
First case report of a curative wedge resection in epithelial-myoepithelial carcinoma of the lung. ( 28653299 )
2017

Variations for Myoepithelioma

Cosmic variations for Myoepithelioma:

9 (show top 50) (show all 267)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM10758 TP53 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.659A>G p.Y220C 17:7674872-7674872 10
2 COSM13570 PIK3CA salivary gland,parotid,carcinoma,myoepithelial carcinoma c.331A>G p.K111E 3:179199156-179199156 10
3 COSM12597 PIK3CA salivary gland,parotid,carcinoma,myoepithelial carcinoma c.3145G>C p.G1049R 3:179234302-179234302 10
4 COSM6963776 KDM5C salivary gland,parotid,carcinoma,myoepithelial carcinoma c.455T>A p.L152* 23:53217863-53217863 10
5 COSM496 HRAS salivary gland,parotid,carcinoma,myoepithelial carcinoma c.181C>A p.Q61K 11:533875-533875 10
6 COSM13168 CTNNB1 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.104T>C p.I35T 3:41224616-41224616 10
7 COSM33765 AKT1 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.49G>A p.E17K 14:104780214-104780214 10
8 COSM6963774 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.455T>A p.L152* 23:53217863-53217863 10
9 COSM6963775 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.254T>A p.L85* 23:53217863-53217863 10
10 COSM307275 TP53 salivary gland,NS,carcinoma,myoepithelial carcinoma c.96+1G>T p.? 17:7676381-7676381 9
11 COSM6920823 STAG2 salivary gland,NS,carcinoma,myoepithelial carcinoma c.1808G>A p.G603E 23:124063192-124063192 9
12 COSM27495 PIK3CA salivary gland,NS,carcinoma,myoepithelial carcinoma c.35G>A p.G12D 3:179198860-179198860 9
13 COSM12459 PIK3CA salivary gland,NS,carcinoma,myoepithelial carcinoma c.1637A>G p.Q546R 3:179218307-179218307 9
14 COSM5609465 MTOR salivary gland,NS,carcinoma,myoepithelial carcinoma c.5534A>T p.E1845V 1:11130608-11130608 9
15 COSM21159 MAP2K4 salivary gland,NS,carcinoma,myoepithelial carcinoma c.752G>A p.S251N 17:12113299-12113299 9
16 COSM553 KRAS salivary gland,NS,carcinoma,myoepithelial carcinoma c.182A>T p.Q61L 12:25227342-25227342 9
17 COSM499 HRAS salivary gland,NS,carcinoma,myoepithelial carcinoma c.182A>G p.Q61R 11:533874-533874 9
18 COSM498 HRAS salivary gland,NS,carcinoma,myoepithelial carcinoma c.182A>T p.Q61L 11:533874-533874 9
19 COSM6916641 ATM salivary gland,NS,carcinoma,myoepithelial carcinoma c.4940T>C p.L1647P 11:108297317-108297317 9
20 COSM446012 salivary gland,NS,carcinoma,myoepithelial carcinoma c.1637A>G p.Q546R 3:179218307-179218307 9
21 COSM244958 salivary gland,NS,carcinoma,myoepithelial carcinoma c.182A>G p.Q61R 11:533874-533874 9
22 COSM307276 salivary gland,NS,carcinoma,myoepithelial carcinoma c.96+1G>T p.? 17:7676381-7676381 9
23 COSM307277 salivary gland,NS,carcinoma,myoepithelial carcinoma c.96+1G>T p.? 17:7676381-7676381 9
24 COSM6920822 salivary gland,NS,carcinoma,myoepithelial carcinoma c.1808G>A p.G603E 23:124063192-124063192 9
25 COSM307278 salivary gland,NS,carcinoma,myoepithelial carcinoma c.96+1G>T p.? 17:7676381-7676381 9
26 COSM3717686 salivary gland,NS,carcinoma,myoepithelial carcinoma c.96+1G>T p.? 17:7676381-7676381 9
27 COSM6916640 salivary gland,NS,carcinoma,myoepithelial carcinoma c.4940T>C p.L1647P 11:108297317-108297317 9
28 COSM3717687 salivary gland,NS,carcinoma,myoepithelial carcinoma c.96+1G>T p.? 17:7676381-7676381 9
29 COSM1658946 VWA5B1 salivary gland,parotid,carcinoma,NS c.1486G>A p.V496I 1:20330897-20330897 8
30 COSM5030964 VHL salivary gland,parotid,carcinoma,NS c.319C>T p.R107C 3:10142166-10142166 8
31 COSM1659032 TXNRD3 salivary gland,parotid,carcinoma,NS c.412A>G p.K138E 3:126647293-126647293 8
32 COSM5030953 TP53 salivary gland,parotid,carcinoma,NS c.38C>T p.P13L 17:7676557-7676557 8
33 COSM11564 TP53 salivary gland,parotid,carcinoma,NS c.742C>G p.R248G 17:7674221-7674221 8
34 COSM44850 TP53 salivary gland,parotid,carcinoma,NS c.494A>T p.Q165L 17:7675118-7675118 8
35 COSM43632 TP53 salivary gland,parotid,carcinoma,NS c.493C>T p.Q165* 17:7675119-7675119 8
36 COSM11305 TP53 salivary gland,parotid,carcinoma,NS c.809T>C p.F270S 17:7673811-7673811 8
37 COSM44640 TP53 salivary gland,parotid,carcinoma,NS c.782+1G>T p.? 17:7674180-7674180 8
38 COSM45307 TP53 salivary gland,parotid,carcinoma,NS c.309C>A p.Y103* 17:7676060-7676060 8
39 COSM43687 TP53 salivary gland,parotid,carcinoma,NS c.641A>G p.H214R 17:7674890-7674890 8
40 COSM11196 TP53 salivary gland,parotid,carcinoma,NS c.734G>T p.G245V 17:7674229-7674229 8
41 COSM43814 TP53 salivary gland,parotid,carcinoma,NS c.587G>C p.R196P 17:7674944-7674944 8
42 COSM43596 TP53 salivary gland,parotid,carcinoma,NS c.841G>A p.D281N 17:7673779-7673779 8
43 COSM43918 TP53 salivary gland,parotid,carcinoma,NS c.809T>A p.F270Y 17:7673811-7673811 8
44 COSM10886 TP53 salivary gland,parotid,carcinoma,NS c.310C>T p.Q104* 17:7676059-7676059 8
45 COSM10690 TP53 salivary gland,parotid,carcinoma,NS c.473G>A p.R158H 17:7675139-7675139 8
46 COSM46283 TP53 salivary gland,parotid,carcinoma,NS c.569C>A p.P190H 17:7674962-7674962 8
47 COSM12013 TP53 salivary gland,parotid,carcinoma,NS c.731G>C p.G244A 17:7674232-7674232 8
48 COSM10646 TP53 salivary gland,parotid,carcinoma,NS c.725G>A p.C242Y 17:7674238-7674238 8
49 COSM10704 TP53 salivary gland,parotid,carcinoma,NS c.844C>T p.R282W 17:7673776-7673776 8
50 COSM44094 TP53 salivary gland,parotid,carcinoma,NS c.716A>G p.N239S 17:7674247-7674247 8

Copy number variations for Myoepithelioma from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 13767 1 1 28000000 Loss Myoepithelioma
2 75376 13 19500000 115169878 Loss Myoepithelioma
3 124183 19 1 6900000 Loss Myoepithelioma
4 127358 19 32400000 35500000 Loss Myoepithelioma
5 195327 5 15000000 18400000 Gain Myoepithelioma
6 247562 9 130300000 141213431 Loss Myoepithelioma
7 249425 9 14200000 33200000 Loss Myoepithelioma

Expression for Myoepithelioma

Search GEO for disease gene expression data for Myoepithelioma.

Pathways for Myoepithelioma

Pathways related to Myoepithelioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.03 GFAP S100B VIM
2
Show member pathways
10.96 GFAP KRT14 KRT18 VIM

GO Terms for Myoepithelioma

Cellular components related to Myoepithelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.85 ACTC1 EWSR1 GFAP KRT14 KRT18 S100A1
2 I band GO:0031674 9.26 ACTC1 S100A1
3 cell periphery GO:0071944 9.13 KRT14 KRT18 PTPRC
4 intermediate filament GO:0005882 8.92 GFAP KRT14 KRT18 VIM

Biological processes related to Myoepithelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 9.32 ACTC1 VIM
2 intermediate filament organization GO:0045109 9.26 GFAP VIM
3 astrocyte development GO:0014002 9.16 GFAP VIM
4 Bergmann glial cell differentiation GO:0060020 8.96 GFAP VIM
5 intermediate filament-based process GO:0045103 8.62 GFAP VIM

Molecular functions related to Myoepithelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.43 EWSR1 GFAP S100A1 S100B TP63 VIM
2 structural constituent of cytoskeleton GO:0005200 9.33 GFAP KRT14 VIM
3 S100 protein binding GO:0044548 9.26 S100A1 S100B
4 keratin filament binding GO:1990254 8.62 KRT14 VIM

Sources for Myoepithelioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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