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MCID: MYP001
MIFTS: 37

Myoepithelioma

Categories: Cancer diseases, Skin diseases
Genes Variations Tissues Related diseases Publications Pathways
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Aliases & Classifications for Myoepithelioma

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MalaCards integrated aliases for Myoepithelioma:

Name: Myoepithelioma 12 54 43 15 71
Benign Myoepithelioma 12 71
Malignant Myoepithelioma 71
Myoepithelial Neoplasm 12
Myoepithelial Adenoma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2661
MeSH 43 D009208
NCIt 49 C40392
SNOMED-CT 67 69291002
UMLS 71 C0027070 C0334699 C1947949
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Summaries for Myoepithelioma

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Disease Ontology : 12 A sweat gland neoplasm that is composed of outgrowths of myoepithelial cells from a sweat gland.

MalaCards based summary : Myoepithelioma, also known as benign myoepithelioma, is related to breast adenomyoepithelioma and breast myoepithelial neoplasm. An important gene associated with Myoepithelioma is ACTC1 (Actin Alpha Cardiac Muscle 1), and among its related pathways/superpathways are Cytoskeletal Signaling and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include salivary gland, breast and bone, and related phenotypes are cardiovascular system and cellular

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Related Diseases for Myoepithelioma

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Diseases related to Myoepithelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 279)
# Related Disease Score Top Affiliating Genes
1 breast adenomyoepithelioma 32.2 SERPINB5 KRT14
2 breast myoepithelial neoplasm 32.0 SERPINB5 KRT14
3 rare tumor 31.5 EWSR1 ACTC1
4 leiomyoma 30.8 VIM S100A1 ACTC1
5 myopericytoma 30.6 S100B ACTC1
6 epithelioid sarcoma 30.5 VIM SMARCB1 MUC1
7 secretory meningioma 30.4 VIM MUC1
8 chondromyxoid fibroma 30.4 VIM S100A1 ACTC1
9 fibroma 30.4 VIM S100A1 KRT14 ACTC1
10 smooth muscle tumor 30.4 VIM S100A1 ACTC1
11 chondrosarcoma 30.3 VIM S100B S100A1 MUC1 EWSR1
12 perivascular epithelioid cell tumor 30.1 VIM S100B MUC1 ACTC1
13 spindle cell sarcoma 30.1 VIM S100B MUC1 ACTC1
14 extraosseous chondrosarcoma 30.1 ZNF444 SMARCB1 EWSR1
15 myoepithelial carcinoma 30.1 ZNF444 VIM SMARCB1 S100A1 PLAG1 MUC1
16 central epithelioid sarcoma 30.1 VIM SMARCB1 KRT18
17 oncocytoma 30.1 VIM S100A1 MUC1 KRT18 KRT14
18 fibrous histiocytoma 30.0 VIM S100B EWSR1 ACTC1
19 myxoid chondrosarcoma 29.9 SMARCB1 S100B MUC1 GFAP EWSR1
20 histiocytoma 29.8 VIM PTPRC EWSR1 ACTC1
21 meningioma, radiation-induced 29.7 VIM SMARCB1 S100B MUC1 GFAP
22 syringoma 29.6 VIM SERPINB5 S100B S100A1 MUC1 GFAP
23 neurilemmoma 29.6 VIM SMARCB1 S100B S100A1 MUC1 GFAP
24 chondrosarcoma, extraskeletal myxoid 29.5 ZNF444 SMARCB1 PLAG1 GFAP EWSR1
25 parachordoma 29.3 ZNF444 VIM TBXT S100A1 MUC1 GFAP
26 sarcoma, synovial 29.2 VIM SMARCB1 S100B MUC1 KRT14 EWSR1
27 pleomorphic adenoma 29.2 VIM TP63 SERPINB5 S100B S100A1 PLAG1
28 ewing sarcoma 29.2 VIM S100B PTPRC KITLG EWSR1
29 chordoma 29.2 VIM TBXT SMARCB1 S100B S100A1 MUC1
30 neurofibroma 29.0 VIM S100B S100A1 MUC1 KITLG ACTC1
31 epithelial-myoepithelial carcinoma 29.0 VIM TP63 SMARCB1 PLAG1 MUC1 KRT14
32 polymorphous low-grade adenocarcinoma 28.9 VIM TP63 SERPINB5 S100B S100A1 MUC1
33 renal cell carcinoma, nonpapillary 28.8 VIM S100A1 MUC1 KRT18 ACTC1
34 sarcoma 28.8 VIM SMARCB1 S100B PTPRC MUC1 EWSR1
35 adenoid cystic carcinoma 28.6 VIM TP63 SERPINB5 S100B S100A1 PLAG1
36 clear cell hidradenoma 11.5
37 breast myoepitheliosis 11.3
38 adenoma 10.7
39 lymphangiectasis 10.5 VIM ACTC1
40 malignant giant cell tumor 10.5 S100B ACTC1
41 papillary ependymoma 10.5 S100B GFAP
42 intravascular papillary endothelial hyperplasia 10.5 VIM ACTC1
43 glomangiomyoma 10.5 VIM ACTC1
44 hydromyelia 10.5 VIM S100B
45 bednar tumor 10.5 VIM S100B
46 primary hepatic neuroendocrine carcinoma 10.5 VIM S100B
47 anaplastic ganglioglioma 10.5 GFAP ACTC1
48 benign metastasizing leiomyoma 10.5 VIM ACTC1
49 hard palate cancer 10.5
50 malignant iris melanoma 10.5 S100B S100A1

Graphical network of the top 20 diseases related to Myoepithelioma:



Diseases related to Myoepithelioma
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Symptoms & Phenotypes for Myoepithelioma

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MGI Mouse Phenotypes related to Myoepithelioma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.02 ACTC1 GFAP KITLG PTPRC S100A1 SMARCB1
2 cellular MP:0005384 10.02 ACTC1 GFAP KITLG KRT14 PTPRC S100A1
3 digestive/alimentary MP:0005381 9.8 GFAP KITLG KRT14 PTPRC SMARCB1 TBXT
4 embryo MP:0005380 9.76 KITLG KRT18 PLAG1 SERPINB5 SMARCB1 TBXT
5 growth/size/body region MP:0005378 9.7 ACTC1 GFAP KITLG KRT14 KRT18 PLAG1
6 normal MP:0002873 9.23 ACTC1 GFAP PTPRC S100A1 S100B SERPINB5
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Drugs & Therapeutics for Myoepithelioma

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Accuracy of Multiparametric Magnetic Resonance Imaging Versus Fine Needle Aspiration Cytology in the Preoperative Work-Up of Parotid Gland Neoplasms Recruiting NCT03849482

Search NIH Clinical Center for Myoepithelioma

Cochrane evidence based reviews: myoepithelioma

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Genetic Tests for Myoepithelioma

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Anatomical Context for Myoepithelioma

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MalaCards organs/tissues related to Myoepithelioma:

40
Salivary Gland, Breast, Bone, Skin, Tongue, Lung, Smooth Muscle
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Publications for Myoepithelioma

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Articles related to Myoepithelioma:

(show top 50) (show all 645)
# Title Authors PMID Year
1
Myoepithelioma with melanocytic colonization (melanocytic myoepithelioma): a case report. 54 61
19515051 2009
2
Giant myoepithelioma of the upper lip. 54 61
16099771 2005
3
Myoepithelioma of the parotid gland initially diagnosed by fine needle aspiration cytology and immunocytochemistry: a case report. 54 61
15717758 2005
4
Malignant myoepithelioma of the salivary gland--an untypical clinical course. 54 61
15619979 2004
5
[Myoepithelial differentiation markers in salivary gland neoplasia]. 54 61
11785118 2001
6
The effect of a reconstituted basement membrane (matrigel) on a human salivary gland myoepithelioma cell line. 54 61
11710645 2001
7
Expression of smooth-muscle actin in cultured cells from human plasmacytoid myoepithelioma. 54 61
9431536 1997
8
[Malignant myoepithelioma associated with in situ and invasive ductal carcinoma. Description of a case and review of the literature]. 54 61
9471611 1997
9
Myoepithelioma: definitions and diagnostic criteria. 54 61
7483010 1995
10
Plasmacytoid monomorphic adenoma of salivary glands. Absence of myogenous differentiation and comparison to spindle cell myoepithelioma. 54 61
8380682 1993
11
Spindle cell squamous carcinoma of the oral region. An immunohistochemical and ultrastructural study on the histogenesis and differential diagnosis with a clinicopathological analysis of six cases. 54 61
1718079 1991
12
Multiple expression of keratins, vimentin, and S-100 protein in pleomorphic salivary adenomas. 54 61
1694334 1990
13
Myoepithelioma-like Hyalinizing Epithelioid Tumors of the Hand With Novel OGT-FOXO3 Fusions. 61
31567281 2020
14
A mitotically active SMARCB1-deficient myoepithelioma-like tumour of the vulvar region with probable benign behaviour. 61
31889550 2020
15
Cutaneous Syncytial Myoepithelioma: A Nondescript Skin Tumor With Serious Diagnostic Pitfalls. 61
31587595 2020
16
Foot plantar soft tissue malignant myoepithelioma tumor: Case report and review of the literature. 61
32000118 2020
17
Myoepithelioma-like tumor of the vulvar region: a case report in China and review of the literature. 61
31915021 2020
18
Metachronous Pancreatic and Thyroid Metastases from Primary Soft-Tissue Myoepithelioma in the Clavicular Region: A Case Report of a Long-Term Survivor. 61
31983728 2020
19
Myoepithelioma of the Lower Eyelid. 61
31868789 2019
20
[Clinicopathological features of lung salivary gland-type tumors]. 61
31818065 2019
21
Cutaneous myoepithelioma of the foot. 61
31769018 2019
22
A Case of Myoepithelioma of the Nasal Cavity. 61
31763237 2019
23
Plasmacytoid cells in salivary pleomorphic adenoma: an alternative interpretation of their immunohistochemical characteristics highlights function and capability for epithelial-mesenchymal transition. 61
31400990 2019
24
Cutaneous Syncytial Myoepithelioma Is Characterized by Recurrent EWSR1-PBX3 Fusions. 61
31135487 2019
25
Myoepithelioma of nasal septum: a rare minor salivary gland tumour. 61
31653626 2019
26
Painful Cutaneous Syncytial Myoepithelioma: From Nonspecific Symptoms to Histopathologic Diagnosis. 61
31615626 2019
27
Plasmacytoid Myoepithelioma of Palate Heading Toward Malignancy: A Rare Case With Immunohistochemical Analysis. 61
30909738 2019
28
Cystic Myoepithelioma of Parapharyngeal Space. 61
31742043 2019
29
Myoepithelioma-like tumour of the vulvar region. 61
31470996 2019
30
Spindle cell myoepithelioma of the parotid gland. 61
31658801 2019
31
Myoepithelioma of the soft tissue: A systematic review of clinical reports. 61
31085025 2019
32
Intracranial Myoepithelioma: A Case Report and Review of Literature. 61
31744974 2019
33
Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours. 61
31209701 2019
34
Canine Spindle Cell Mammary Tumor: A Retrospective Study of 67 Cases. 61
30857503 2019
35
Basal cell adenoma and myoepithelioma of the parotid gland: patterns of enhancement at two-phase CT in comparison with Warthin tumor. 61
31120425 2019
36
Case of cutaneous myoepithelioma managed with surgical resection without recurrence for 4 years. 61
30672605 2019
37
Characterisation of DOG-1 Expression in Salivary Gland Tumours and Comparison with Myoepithelial Markers. 61
29671211 2019
38
EWSR1-PBX3 gene fusion in cutaneous syncytial myoepithelioma. 61
30834570 2019
39
Utility of smooth muscle actin and CD117 as reliable markers in the diagnosis of salivary gland neoplasms. 61
31516227 2019
40
Misinterpreted Myoepithelial Carcinoma of Salivary Gland: A Challenging and Potentially Significant Pitfall. 61
30789358 2019
41
New fusion sarcomas: histopathology and clinical significance of selected entities. 61
30633925 2019
42
Myoepithelioma-like tumor of the vulvar region showing infiltrative growth and harboring only a few estrogen receptor-positive cells: A case report. 61
30737997 2019
43
Myoepithelioma of bone: ultrastructural, immunohistochemical and molecular study of three cases. 61
31766935 2019
44
Clear cell, giant myoepithelioma of tongue base: a diagnostic and surgical challenge. 61
30665928 2019
45
EWSR1-PBX3 fused myoepithelioma arising in metatarsal bone: Case report and review of the literature. 61
30605259 2019
46
[Primary malignant myoepithelioma of the humerus: a case report and literature review]. 61
30605987 2018
47
Hierarchical Cluster Analysis of Cytokeratins and Stem Cell Expression Profiles of Canine Cutaneous Epithelial Tumors. 61
30071783 2018
48
[Myxoid variant of angiomatoid fibrous histiocytoma: a clinicopathologic analysis of 3 cases]. 61
30220125 2018
49
Myoepithelioma occurring in the posterior mediastinum harboring EWSR1 rearrangement: a case report. 61
30053180 2018
50
[Clinicopathologic characterization of malignant mixed tumor of the skin accompanied by eccrine porocarcinoma]. 61
29996320 2018
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Variations for Myoepithelioma

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Copy number variations for Myoepithelioma from CNVD:

7
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 13767 1 1 28000000 Loss Myoepithelioma
2 75376 13 19500000 115169878 Loss Myoepithelioma
3 124183 19 1 6900000 Loss Myoepithelioma
4 127358 19 32400000 35500000 Loss Myoepithelioma
5 195327 5 15000000 18400000 Gain Myoepithelioma
6 247562 9 130300000 141213431 Loss Myoepithelioma
7 249425 9 14200000 33200000 Loss Myoepithelioma
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Expression for Myoepithelioma

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Search GEO for disease gene expression data for Myoepithelioma.
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Pathways for Myoepithelioma

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Pathways related to Myoepithelioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cytoskeletal Signaling 4
12.05 VIM MUC1 KRT18 ACTC1
2
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.38 VIM TP63 TBXT KITLG
3
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.23 VIM S100B GFAP
4
Cytoskeleton remodeling Neurofilaments 22
Show member pathways
 10.96 VIM KRT18 KRT14 GFAP
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GO Terms for Myoepithelioma

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Cellular components related to Myoepithelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.97 VIM TP63 TBXT SERPINB5 S100B S100A1
2 cell periphery GO:0071944 9.13 PTPRC KRT18 KRT14
3 intermediate filament GO:0005882 8.92 VIM KRT18 KRT14 GFAP

Biological processes related to Myoepithelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 post-anal tail morphogenesis GO:0036342 9.4 TP63 TBXT
2 positive regulation of glial cell proliferation GO:0060252 9.37 PLAG1 GFAP
3 intermediate filament organization GO:0045109 9.32 VIM GFAP
4 astrocyte development GO:0014002 9.26 VIM GFAP
5 Bergmann glial cell differentiation GO:0060020 9.16 VIM GFAP
6 positive regulation of histone H4 acetylation GO:0090240 8.96 SMARCB1 MUC1
7 intermediate filament-based process GO:0045103 8.62 VIM GFAP

Molecular functions related to Myoepithelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.8 VIM TP63 S100B S100A1 GFAP EWSR1
2 structural constituent of cytoskeleton GO:0005200 9.33 VIM KRT14 GFAP
3 S100 protein binding GO:0044548 9.26 S100B S100A1
4 p53 binding GO:0002039 9.13 TP63 SMARCB1 MUC1
5 keratin filament binding GO:1990254 8.62 VIM KRT14
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Sources for Myoepithelioma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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