Myofascial Pain Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MYF002 MIFTS: 46	Myofascial Pain Syndrome Categories: Muscle diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Myofascial Pain Syndrome

MalaCards integrated aliases for Myofascial Pain Syndrome:

Name: Myofascial Pain Syndrome ¹² ¹⁵ ¹⁷

Myofascial Pain Syndromes ⁴⁴ ⁷¹

Myofascial Pain Dysfunction Syndrome ⁵⁴

Fibromyalgia ⁷¹

Classifications:

MalaCards categories:
Anatomical: Muscle diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:431

MeSH ⁴⁴ D009209

EFO ¹⁷ EFO_1001054

UMLS ⁷¹ C0016053 C0027073

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Summaries for Myofascial Pain Syndrome

MalaCards based summary : Myofascial Pain Syndrome, also known as myofascial pain syndromes, is related to fibromyalgia and glossopharyngeal neuralgia, and has symptoms including muscle weakness, fatigue and myoclonus. An important gene associated with Myofascial Pain Syndrome is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Development Endothelin-1/EDNRA signaling and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Gabapentin and Etoricoxib have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, spinal cord and cortex, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : ⁷⁴ Myofascial pain syndrome (MPS), also known as chronic myofascial pain (CMP), is a syndrome characterized... more...

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Related Diseases for Myofascial Pain Syndrome

Diseases related to Myofascial Pain Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 176)

#	Related Disease	Score	Top Affiliating Genes
1	fibromyalgia	31.6	POMC NGF CALCA BDNF
2	glossopharyngeal neuralgia	30.8	TAC1 POMC
3	bruxism	30.6	TAC1 LAPTM4A
4	radiculopathy	30.3	TAC1 LAPTM4A
5	hypochondriasis	30.2	POMC BDNF
6	frozen shoulder	30.2	LAPTM4A ASIC3
7	pulpitis	30.1	TRPV1 KNG1
8	facial neuralgia	30.1	TAC1 LIPN LAPTM4A
9	complex regional pain syndrome	30.1	TAC1 POMC CALCA
10	sleep disorder	29.9	TAC1 POMC BDNF
11	bursitis	29.8	TAC1 LAPTM4A KNG1 CALCA
12	anxiety	29.5	TAC1 POMC NGF BDNF
13	reflex sympathetic dystrophy	29.4	TRPV1 TAC1 LAPTM4A KNG1 CALCA
14	algoneurodystrophy	29.4	TAC1 NGF KNG1 CALCA
15	major depressive disorder	29.3	TAC1 POMC NGF BDNF
16	irritable bowel syndrome	29.2	TRPV1 TAC1 POMC NGF BDNF
17	somatoform disorder	29.0	TRPV1 TAC1 NGF LAPTM4A CALCA BDNF
18	paine syndrome	28.8	TRPV1 TAC1 NGF LAPTM4A KNG1 CALCA
19	trigeminal neuralgia	28.4	TRPV1 TAC1 NGF LIPN KNG1 CALCA
20	peripheral nervous system disease	28.3	TRPV1 TAC1 POMC NGF KNG1 CALCA
21	chronic pain	10.6
22	trichorhinophalangeal syndrome	10.5
23	chronic fatigue syndrome	10.4
24	patellofemoral pain syndrome	10.3	TAC1 LAPTM4A
25	neurodermatitis	10.3	TAC1 POMC
26	arachnoiditis	10.3	TAC1 POMC
27	somatization disorder	10.3	TAC1 POMC
28	shoulder impingement syndrome	10.3	TAC1 LAPTM4A
29	ectopic cushing syndrome	10.3	POMC CALCA
30	carbamazepine allergy	10.3	TAC1 CALCA
31	taylor's syndrome	10.3	TAC1 CALCA
32	nasal cavity adenocarcinoma	10.2	POMC CALCA
33	motion sickness	10.2	TAC1 POMC
34	graves disease 1	10.2	POMC CALCA
35	interval angle-closure glaucoma	10.2	TAC1 KNG1
36	intracranial vasospasm	10.2	TAC1 KNG1
37	acute apical periodontitis	10.2	TAC1 KNG1
38	sick building syndrome	10.2	TRPV1 POMC
39	akinetopsia	10.2	TAC1 KNG1
40	autonomic dysfunction	10.2
41	headache	10.2
42	spasticity	10.2
43	hyperhidrosis, gustatory	10.2	TRPV1 TAC1
44	premenstrual tension	10.2	POMC LIPN
45	facial dermatosis	10.2	TRPV1 TAC1
46	pseudopterygium	10.2	TRPV1 TAC1
47	lung oat cell carcinoma	10.2	POMC CALCA
48	atypical depressive disorder	10.2	POMC BDNF
49	retrograde amnesia	10.2	POMC BDNF
50	dental pulp disease	10.2	TRPV1 TAC1

Graphical network of the top 20 diseases related to Myofascial Pain Syndrome:

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Symptoms & Phenotypes for Myofascial Pain Syndrome

UMLS symptoms related to Myofascial Pain Syndrome:

muscle weakness, fatigue, myoclonus, back pain, myalgia, torticollis, pain, chronic pain, sciatica, muscle cramp, muscle rigidity, muscle spasticity, myofascial trigger point pain

GenomeRNAi Phenotypes related to Myofascial Pain Syndrome according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-102	9.36	POMC
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-16	9.36	NGF
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-163	9.36	NGF
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-214	9.36	NGF
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-29	9.36	NGF
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-32	9.36	LAPTM4A POMC
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-47	9.36	NGF
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-61	9.36	LAPTM4A
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-79	9.36	LAPTM4A
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-88	9.36	POMC

MGI Mouse Phenotypes related to Myofascial Pain Syndrome:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.76	ASIC3 BDNF KNG1 NGF PDGFRB POMC
2	homeostasis/metabolism	MP:0005376	9.61	ASIC3 BDNF KNG1 LAPTM4A LIPN NGF
3	integument	MP:0010771	9.17	ASIC3 BDNF NGF PDGFRB POMC TAC1

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Drugs & Therapeutics for Myofascial Pain Syndrome

Drugs for Myofascial Pain Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 288)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Gabapentin

Approved, Investigational

Phase 4

60142-96-3

3446

Etoricoxib

Approved, Investigational

Phase 4

202409-33-4

123619

Tramadol

Approved, Investigational

Phase 4

27203-92-5

33741

Perphenazine

Approved

Phase 4

58-39-9

4748

Modafinil

Approved, Investigational

Phase 4

68693-11-8

4236

Trazodone

Approved, Investigational

Phase 4

19794-93-5

5533

Sodium citrate

Approved, Investigational

Phase 4

68-04-2

Histamine

Approved, Investigational

Phase 4

51-45-6, 75614-87-8

774

Benzocaine

Approved, Investigational

Phase 4

1994-09-7, 94-09-7

2337

tannic acid

Approved

Phase 4

1401-55-4

Fluoxetine

Approved, Vet_approved

Phase 4

54910-89-3

3386

Paroxetine

Approved, Investigational

Phase 4

61869-08-7

43815

Eszopiclone

Approved, Investigational

Phase 4

138729-47-2

969472

Ketamine

Approved, Vet_approved

Phase 4

6740-88-1

3821

Granisetron

Approved, Investigational

Phase 4

109889-09-0

3510

Flunarizine

Approved

Phase 4

52468-60-7

941361

Acetaminophen

Approved

Phase 4

103-90-2

1983

Amitriptyline

Approved

Phase 4

50-48-6

2160

Citalopram

Approved

Phase 4

59729-33-8

2771

Ketorolac

Approved

Phase 4

74103-06-3, 66635-83-4

3826

Ibuprofen

Approved

Phase 4

15687-27-1

3672

Clonazepam

Approved, Illicit

Phase 4

1622-61-3

2802

Ethanol

Approved

Phase 4

64-17-5

702

Naltrexone

Approved, Investigational, Vet_approved

Phase 4

16590-41-3

5360515

Magnesium Sulfate

Approved, Investigational, Vet_approved

Phase 4

7487-88-9

24083

Lidocaine

Approved, Vet_approved

Phase 4

137-58-6

3676

Buprenorphine

Approved, Illicit, Investigational, Vet_approved

Phase 4

52485-79-7

40400 644073

Naloxone

Approved, Vet_approved

Phase 4

465-65-6

5284596

Diphenhydramine

Approved, Investigational

Phase 4

147-24-0, 58-73-1

3100

Suvorexant

Approved, Investigational

Phase 4

1030377-33-3

Promethazine

Approved, Investigational

Phase 4

60-87-7

4927

Triamcinolone

Approved, Vet_approved

Phase 4

124-94-7

31307

Glutamic acid

Approved, Nutraceutical

Phase 4

56-86-0

33032

Citric acid

Approved, Nutraceutical, Vet_approved

Phase 4

77-92-9

311

Vitamin A

Approved, Nutraceutical, Vet_approved

Phase 4

68-26-8, 11103-57-4

445354

Cyclooxygenase 2 Inhibitors

Phase 4

Gastrointestinal Agents

Phase 4

Antipsychotic Agents

Phase 4

Antiemetics

Phase 4

Quetiapine Fumarate

Phase 4

111974-72-2

Central Nervous System Stimulants

Phase 4

Citrate

Phase 4

Anesthetics, Intravenous

Phase 4

Anesthetics, General

Phase 4

Cytochrome P-450 Enzyme Inhibitors

Phase 4

Histamine Antagonists

Phase 4

Histamine Phosphate

Phase 4

51-74-1

65513

Histamine H1 Antagonists

Phase 4

Excitatory Amino Acid Antagonists

Phase 4

Trace Elements

Phase 4

Interventional clinical trials:

(show top 50) (show all 824)

#	Name	Status	NCT ID	Phase	Drugs
1	An Eight Week, Double-Blind Efficacy Study of Cyclobenzaprine ER (Amrix TM) Augmentation to Alleviate Fibromyalgia Fatigue and Muscle Pain	Unknown status	NCT01041495	Phase 4	cyclobenzaprine ER (AMRIX);placebo
2	Study Proposal - A Randomized Double-blinded Study Comparing Adding Etoricoxib Versus Placebo to Female Patients With Fibromyalgia-analysis of Organic and Psychiatric Measures	Unknown status	NCT00755521	Phase 4	etoricoxib
3	Low Dose Naltrexone for Treatment of Pain in Patients With Fibromyalgia - Effect Via a Central Mechanism? A Randomized, Double-blinded, Placebo-controlled, Crossover Study.	Unknown status	NCT02806440	Phase 4	Low dose naltrexone;Placebo
4	The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair	Unknown status	NCT02419443	Phase 4	Gabapentin;Placebo
5	A Randomized Controlled Trial Comparing the Efficay and Tolerability of Ai Chi Versus Stretching in Fibromyalgia Management: a Six Months Study	Completed	NCT00600574	Phase 4
6	The Study of Heart Rate Variability in Patients With Fibromyalgia - Effects of Strengthening Exercises	Completed	NCT02004405	Phase 4
7	Pool-based Exercise in Fibromyalgia Management: a Prospective Randomized Comparison Between Stretching and Ai Chi	Completed	NCT00550641	Phase 4
8	Fixed Versus Flexible Dosing of Pregabalin in Patients With Fibromyalgia	Completed	NCT01226667	Phase 4	Pregabalin
9	A Randomized, Pilot Clinical Trial to Assess the Comparative Efficacy and Tolerability of Quetiapine XR Versus Amitriptyline for the Treatment of Patients With Fibromyalgia	Completed	NCT00766350	Phase 4	amitriptyline;quetiapine
10	An Eight Week, Double-Blind Efficacy Study of Armodafinil Augmentation to Alleviate Fibromyalgia Fatigue	Completed	NCT00678691	Phase 4	armodafinil;placebo
11	Open Label Trial Concerning the Effectiveness of Trazodone in the Treatment of Fibromyalgia (Phase I) and Its Augmentation With Pregabalin in Trazodone Partial Responders (Phase II)	Completed	NCT00791739	Phase 4	trazodone, pregabalin
12	The Efficacy of Topical Thiocolchicoside in Cervical Myofascial Pain Syndrome: Triple-Arm, Single-Blind, Randomized, Prospective, Phase IV Clinical Study	Completed	NCT00272532	Phase 4	Thiocolchicoside
13	Treatment of Myofascial Pain Syndrome With Lidocaine Injection and Physical Therapy, Alone or in Combination: a Single-blind, Randomized, Controlled Clinical Trial.	Completed	NCT01250184	Phase 4	Lidocaine injection
14	An Open-Label Pilot Study to Assess Potential Mechanisms for Fibromyalgia in Peripheral Tissue Innervation That Could Predict Therapeutic Responsiveness to Milnacipran	Completed	NCT01125423	Phase 4	Milnacipran
15	A Pilot Study on the Combined Use of Cognitive Behavioral Therapy (CBT) and Milnacipran	Completed	NCT01038323	Phase 4	Educational with milnacipran
16	A 6-month, Open-label, Safety Trial Of Pregabalin In Adolescent Patients With Fibromyalgia	Completed	NCT01020526	Phase 4	pregabalin
17	A 15 Week, Randomized, Double Blind, Parallel-group, Placebo-controlled, Flexible-dose, Safety And Efficacy Study Of Pregabalin In Adolescents (12-17 Years Old) With Fibromyalgia	Completed	NCT01020474	Phase 4	placebo;pregabalin (Lyrica)
18	Quetiapine Compared With Placebo in the Management of Fibromyalgia	Completed	NCT01458964	Phase 4	Quetiapine
19	Effects of a 12 Week Milnacipran 200 mg Treatment on Pain Perception and Pain Processing in Fibromyalgia - An Open Label Study	Completed	NCT01288807	Phase 4	Milnacipram
20	Perception of Discomfort and Psychosocial Difficulties in People With Diagnosis of Fibromyalgia and Predominant Neck Pain	Completed	NCT02078791	Phase 4	Botox infiltration
21	A Randomized, Double-blind,Placebo-controlled, Two-way Crossover Study to Evaluate the Effect of Milnacipran on Pain Processing and Functional Magnetic Resonance Imaging Activation Patterns in Patients With Fibromyalgia	Completed	NCT01173055	Phase 4	milnacipran;Placebo
22	A Multicenter, Randomized, Double-Blind, Placebo-Controlled Switch Study to Evaluate the Safety, Tolerability and Efficacy of Milnacipran in Patients With an Inadequate Response to Duloxetine for the Treatment of Fibromyalgia	Completed	NCT01077375	Phase 4	Placebo;Milnacipran
23	A Multicenter, Randomized, Double-blind, Placebo-Controlled Discontinuation Study of the Durability of Effect of Milnacipran for the Treatment of Fibromyalgia in Patients Receiving Long-term Milnacipran Treatment	Completed	NCT01014585	Phase 4	Placebo;Milnacipran
24	Paroxetine-CR (Paxil-CR) in the Treatment of Patients With Fibromyalgia Syndrome: A Randomized, Double Blind, Parallel Group, Flexible Dose, Placebo Controlled Trial.	Completed	NCT00610610	Phase 4	Paroxetine CR;Placebo
25	Eszopiclone in the Treatment of Insomnia and Associated Symptoms of Fibromyalgia	Completed	NCT00392041	Phase 4	Eszopiclone;placebo
26	Ultracet (Tramadol HCL [37.5 mg]/Acetaminophen [325 mg]) Combination Tablets in the Treatment of the Pain of Fibromyalgia	Completed	NCT00766675	Phase 4	Tramadol hydrochloride;Acetaminophen
27	Effectiveness of Strengthening Exercises Using the Swiss Ball for Patients With Fibromyalgia: a Randomized Controlled Trial	Completed	NCT02063750	Phase 4
28	The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia	Completed	NCT01234675	Phase 4	Milnacipran;Placebo
29	Combining N-of-1 Trials to Assess Fibromyalgia Therapies	Completed	NCT00000428	Phase 4	Amitriptyline;Amitriptyline plus Fluoxitine
30	Flexible Dosed Duloxetine Versus Placebo in the Treatment of Fibromyalgia	Completed	NCT00673452	Phase 4	duloxetine hydrochloride;placebo
31	A Double Blind, Randomized Placebo Controlled Study of the Efficacy, Safety and Tolerability of Quetiapine Fumarate Sustained Release(Seroquel SRTM) in the Treatment of Major Depression With Comorbid Fibromyalgia Syndrome.	Completed	NCT00675896	Phase 4	Quetiapine Fumarate Sustained Release;Placebo
32	A Pilot Study on the Use of Nociceptive Flexion Reflex for Fibromyalgia	Completed	NCT00965601	Phase 4
33	Quetiapine (Seroquel XR) for the Treatment of Fibromyalgia: a Clinical and Mechanistic Pilot Study	Completed	NCT00983320	Phase 4	quetiapine;placebo
34	A Randomized, Double-Blind Comparison of Duloxetine 30 mg QD and Placebo in Adult Patients With Fibromyalgia	Completed	NCT00965081	Phase 4	Duloxetine;Placebo
35	Randomized, Double-blind, Placebo-controlled Trial to Measure the Efficacy and Safety of Vitamin D3 in Patients With Fibromyalgia.	Completed	NCT03369379	Phase 4	D3 Vitamin
36	Ambulatory Infusions of Lidocaine and Ketamine for Management of Chronic Pain: an Observational Prospective Study	Completed	NCT04123652	Phase 4	Lidocaine Hydrochloride 2% Intravenous Solution, DIN 02421992
37	Probe Study to Evaluate the Efficacy of Botulinum Toxin Serotype A Injections for Cervicobrachial Myofascial Syndrome	Completed	NCT00241215	Phase 4	Botulinum toxin serotype A
38	The Serotonin Receptor Type 3 Antagonist Granisetron as a New Treatment Approach for Patients With Chronic Myofascial Pain in the Orofacial Muscles	Completed	NCT02230371	Phase 4	Granisetron;Control (placebo)
39	Plasma Rich in Growth Factors Effectiveness for Myofascial Pain Treatment in Masticatory Muscles: a Randomized Controlled Clinical Trial	Completed	NCT04040309	Phase 4	Lidocaine injection
40	Neurologic Signatures of Chronic Pain Disorders	Completed	NCT02747940	Phase 4	flunarizine and/or pregabalin
41	A Randomized, Single-dose, Parallel-group Study to Evaluate the Pharmacokinetic Profiles of Two Formulation of Pregabalin in Healthy Volunteers Under Fasting Conditions	Completed	NCT03712475	Phase 4	Pregabalin
42	Trigger Point Injection for Myofascial Pain Syndrome in the Low Back (T-PIMPS): A Randomized Controlled Trial.	Recruiting	NCT04704297	Phase 4	Treatment of Myofascial Pain Syndrome in the low back. This intervention will be based on outcomes of the medications listed below.;Evaluation of functional ability using a patient centered functional score known as the Modified Oswestry Disability Index (MODI). The intervention will be based on outcomes of medications below.;Following up with participants 60-72 hours after treatment in the Emergency Department. This intervention will be based on outcomes of the medications listed below.
43	Efficacy and Tolerability of Micronized and Ultramicronized Palmitoylethanolamide in Fibromyalgia Patients: A Double-blind, Randomized, Placebo-controlled Clinical Trial	Recruiting	NCT04488926	Phase 4	Standard Therapy;Rescue Drug
44	Determining Optimal Treatment Sequences in Anxious Depression (DOTS-AD)	Recruiting	NCT04245748	Phase 4	Escitalopram;Duloxetine
45	Anti-CGRP Neutralizing Antibody for Modulation of Neurogenic Inflammation in Trigeminal and Glossopharyngeal Pain Associated With Small Fiber Neuropathy/Fibromyalgia	Recruiting	NCT04158752	Phase 4	Galcanezumab
46	Effect of Duloxetine on Opioid Use After Total Knee Arthroplasty: A Double-blinded Randomized Control Trial	Active, not recruiting	NCT03271151	Phase 4	Cymbalta
47	Magnesium Sulphate Injection in Treatment of Myofascial Trigger Points in Masseter Muscle	Not yet recruiting	NCT04742140	Phase 4	Magnesium sulfate;Saline
48	Effectiveness, Cost-utility and Neurobiological Effects of Low-dose Naltrexone in Patients With Fibromyalgia (INNOVA Project)	Not yet recruiting	NCT04739995	Phase 4	Low-dose naltrexone
49	Local Injection of Lidocaine Versus Ischemic Compression in Treatment of Woman With Chronic Pelvic Pain Caused by Abdominal Myofascial Pain Syndrome: Randomized Clinical Trial.	Terminated	NCT00628355	Phase 4	lidocaine
50	A Randomized Controlled Trial Testing Buprenorphine as a Treatment in Opiate Dependent Pain Patients	Terminated	NCT00552578	Phase 4	buprenorphine/naloxone;buprenorphine/naloxone

Search NIH Clinical Center for Myofascial Pain Syndrome

Cochrane evidence based reviews: myofascial pain syndromes

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Genetic Tests for Myofascial Pain Syndrome

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Anatomical Context for Myofascial Pain Syndrome

MalaCards organs/tissues related to Myofascial Pain Syndrome:

⁴⁰

Skeletal Muscle, Spinal Cord, Cortex, Amygdala, Pineal, Skin, Brain

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Publications for Myofascial Pain Syndrome

Articles related to Myofascial Pain Syndrome:

(show top 50) (show all 821)

#	Title	Authors	PMID	Year
1	An unusual complication of quadriparesis after trigger point injection: a case report. ⁶¹	Sangondimath G...Hari Krishan M	33009247	2021
2	Specialty-Specific Diagnoses in Pediatric Patients With Postconcussion Syndrome: Experience From a Multidisciplinary Concussion Clinic. ⁶¹	Shah AS...Brodsky JR	33605602	2021
3	The association between exposure to domestic abuse in women and the development of syndromes indicating central nervous system sensitisation: a retrospective cohort study using UK primary care records. ⁶¹	Chandan JS...Nirantharakumar K	33559289	2021
4	The Effect of Extracorporeal Shock Wave Therapy on Pain Intensity and Neck Disability for Patients With Myofascial Pain Syndrome in the Neck and Shoulder: A Meta-Analysis of Randomized Controlled Trials. ⁶¹	Jun JH...Suh DC	32520797	2021
5	"Quantitative Ultrasound Texture Feature Changes with Conservative treatment of the Trapezius Muscle in female patients with Myofascial Pain Syndrome". ⁶¹	Sancar M...Kumbhare D	33480607	2021
6	Optimal duration of stretching exercise in patients with chronic myofascial pain syndrome: A randomized controlled trial. ⁶¹	Mansoori SS...Harrison DE	33367925	2021
7	Effectiveness of extracorporeal shock wave therapy versus standard care in the treatment of neck and upper back myofascial pain: a single blinded randomised clinical trial. ⁶¹	Rahbar M...Dolatkhah N	32731757	2021
8	Predictive factors of response in radial Extracorporeal Shock-waves Therapy for Myofascial and Articular Pain: A retrospective cohort study. ⁶¹	Sugawara AT...Dias CB	33492278	2021
9	Leiomyosarcoma of the small intestine presenting as abdominal myofascial pain syndrome (AMPS): case report. ⁶¹	Niraj G...Richards CJ	32970610	2021
10	Comparative Effectiveness of Thai Herbal Formula (Thor-Ra-Nee-San-Tha-Kat) Versus Naproxen for Chronic Myofascial Pain: A Pilot Randomized-Controlled Trial. ⁶¹	Vichiansiri R...Padumanonda T	33216613	2021
11	Ultrasound-guided interventional procedures for myofascial trigger points: a systematic review. ⁶¹	Diep D...Kumbhare D	33159004	2021
12	Effects of cognitive behavioral therapy on orofacial pain conditions. ⁶¹	Noma N...Sasaki K	33298629	2020
13	The Prevalence of Psychiatric and Chronic Pain Comorbidities in Fibromyalgia: an ACTTION systematic review. ⁶¹	Kleykamp BA...Dworkin RH	33383293	2020
14	Quantitative response of healthy muscle following the induction of capsaicin: an exploratory randomized controlled trial. ⁶¹	Evans V...Kumbhare D	33308274	2020
15	Neuroticism Traits and Anxiety Symptoms are Exhibited in Athletes With Chronic Gastrocnemius Myofascial Pain Syndrome. ⁶¹	San-Antolin M...Calvo-Lobo C	33065704	2020
16	Sonography-guided trigger point injections in abdominal myofascial pain syndrome. ⁶¹	Rhim HC...Kim DH	33285730	2020
17	Characteristics of chiropractic patients treated at the University of Johannesburg chiropractic student clinic and relevance to the educational process. ⁶¹	Ismail F...Peterson C	33316062	2020
18	Criteria Used for the Diagnosis of Myofascial Trigger Points in Clinical Trials on Physical Therapy: Updated Systematic Review. ⁶¹	Li L...Barbero M	32841969	2020
19	Treatment of Localized and Referred Masticatory Myofascial Pain with Botulinum Toxin Injection. ⁶¹	Montes-Carmona JF...Infante-Cossio P	33374687	2020
20	Effect of Physical Exercise Programs on Myofascial Trigger Points-Related Dysfunctions: A Systematic Review and Meta-analysis. ⁶¹	Guzman-Pavon MJ...Alvarez-Bueno C	33011790	2020
21	Needling on trigger point promotes muscle regeneration after bupivacaine injection induced injury. ⁶¹	Chen J...Liu X	33132179	2020
22	The efficacy of fascial plane blocks for myofascial pain syndrome: do they achieve long-term results? ⁶¹	Piraccini E...Byrne H	33271010	2020
23	The pathophysiological nature of sarcomeres in trigger points in patients with myofascial pain syndrome: A preliminary study. ⁶¹	Jin F...Qi F	32841448	2020
24	Serum inflammatory and oxidative stress biomarkers levels are associated with pain intensity, pressure pain threshold and quality of life in myofascial pain syndrome. ⁶¹	Shakouri SK...Hashemian M	33160410	2020
25	Moxibustion therapy on myofascial pain syndrome: An evidence-based clinical practice guideline. ⁶¹	Wu Z...Xie Q	33181637	2020
26	Myofascial Pain Syndrome and Its Relation to Trigger Points, Facial Form, Muscular Hypertrophy, Deflection, Joint Loading, Body Mass Index, Age and Educational Status. ⁶¹	Sabeh AM...Mawardi HH	33437714	2020
27	Prevalence And Impact Of Myofascial Pain Syndrome In Relapsing-Remitting Multiple Sclerosis And The Effects Of Local Anesthetic Injections For Short-Term Treatment. ⁶¹	Tutuncu M...Soysal A	33022587	2020
28	Comments on Aydin et al: The Effectiveness of Dry Needling and Exercise Therapy in Patients with Dizziness Caused by Cervical Myofascial Pain Syndrome; a Prospective Randomized Clinical Study. ⁶¹	De Hertogh W...Castien R	32358602	2020
29	Authors' Reply: Letter to the Editor Regarding "The Effectiveness of Dry Needling and Exercise Therapy in Patients with Dizziness Caused by Cervical Myofascial Pain Syndrome; Prospective Randomized Clinical Study". ⁶¹	Aydin T...Karacan I	32358610	2020
30	Transcranial direct current stimulation improves myofascial pain syndrome and chronic fatigue. ⁶¹	Misse RG...Shinjo SK	33213134	2020
31	An electroencephalography (EEG) study of short-term electromyography (EMG) biofeedback training in patients with myofascial pain syndrome in the upper trapezius. ⁶¹	Kaewcum N...Siripornpanich V	33132529	2020
32	The assessment of affective temperament and life quality in myofascial pain syndrome patients. ⁶¹	Badil Guloglu S...Tunc S	33084454	2020
33	Erector spinae plane block and rhomboid intercostal block for the treatment of post-mastectomy pain syndrome. ⁶¹	Piraccini E...Maitan S	33447197	2020
34	Comparison of efficacy of corticosteroid injection versus extracorporeal shock wave therapy on inferior trigger points in the quadratus lumborum muscle: a randomized clinical trial. ⁶¹	Eftekharsadat B...Dolatkhah N	33076888	2020
35	The Levels of Insulin-Like Growth Factor in Patients with Myofascial Pain Syndrome and in Healthy Controls. ⁶¹	Grosman-Rimon L...Kumbhare D	33026183	2020
36	A systematic review of musculoskeletal complaints, symptoms, and pathologies related to mobile phone usage. ⁶¹	Zirek E...Griffiths MD	32861360	2020
37	Extra-spinal sciatica and sciatica mimics: a scoping review. ⁶¹	Siddiq MAB...Rasker JJ	32989195	2020
38	Ultrasound Imaging of Injections in Masseter Muscle without Contrast Agent Using Strain Elastography and a Novel B-Mode Spatiotemporal Filter. ⁶¹	Sanabria SJ...Rominger MB	32753287	2020
39	The Influence of Pro-inflammatory Cytokines and Genetic Variants in the Development of Fibromyalgia: A Traditional Review. ⁶¹	Peck MM...Malik BH	33042712	2020
40	Ashi Acupuncture Versus Local Anesthetic Trigger Point Injections in the Treatment of Abdominal Myofascial Pain Syndrome: A Randomized Clinical Trial. ⁶¹	Mitidieri AMS...Rosa-E-Silva JC	32967393	2020
41	Ultrasound-guided dextrose injection treatment for chronic myofascial pain syndrome: A retrospective case series. ⁶¹	Chou Y...Lai YC	32349034	2020
42	Rate and maintenance of improvement of myofascial pain with dry needling alone vs. dry needling with intramuscular electrical stimulation: a randomized controlled trial. ⁶¹	Brennan K...Jupiter DC	32990529	2020
43	A comparison of dry needling and kinesiotaping therapies in myofascial pain syndrome: A randomized clinical study. ⁶¹	Yilmaz N...Demir O	33089092	2020
44	Opioid Reduction and Long-Term Outcomes in Abdominal Myofascial Pain Syndrome (AMPS): A 6-Year Longitudinal Prospective Audit of 207 Patients. ⁶¹	Niraj G...Alva S	32967395	2020
45	Myofascial Pain Syndrome: A Narrative Review Identifying Inconsistencies in Nomenclature. ⁶¹	Phan V...Gerber L	31736284	2020
46	Ultrasound measurements of superficial and deep masticatory muscles in various postures: reliability and influencers. ⁶¹	Chang PH...Ozcakar L	32873849	2020
47	Treatment and management of myofascial pain syndrome. ⁶¹	Urits I...Viswanath O	33004157	2020
48	Chronic Facial Pain: Trigeminal Neuralgia, Persistent Idiopathic Facial Pain, and Myofascial Pain Syndrome-An Evidence-Based Narrative Review and Etiological Hypothesis. ⁶¹	Gerwin R	32992770	2020
49	Comparison of dry needling and trigger point manual therapy in patients with neck and upper back myofascial pain syndrome: a systematic review and meta-analysis. ⁶¹	Lew J...Nair P	32962567	2020
50	Clinical Characteristics of Myofascial Pain Syndrome with Psychological Stress in Patients with Cancer. ⁶¹	Hasuo H...Fukunaga M	32996846	2020

Sources

Genes for Myofascial Pain Syndrome

Genes related to Myofascial Pain Syndrome (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	POMC	Proopiomelanocortin	Protein Coding	11.55	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	LAPTM4A	Lysosomal Protein Transmembrane 4 Alpha	Protein Coding	10.13	DISEASES inferred ¹⁵
3	TAC1	Tachykinin Precursor 1	Protein Coding	7.37	DISEASES inferred ¹⁵
4	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	6.49	DISEASES inferred ¹⁵
5	ASIC3	Acid Sensing Ion Channel Subunit 3	Protein Coding	6.05	DISEASES inferred ¹⁵
6	KNG1	Kininogen 1	Protein Coding	5.92	DISEASES inferred ¹⁵
7	TRPV1	Transient Receptor Potential Cation Channel Subfamily V Member 1	Protein Coding	5.6	DISEASES inferred ¹⁵
8	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	5.58	DISEASES inferred ¹⁵
9	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	5.42	Novoseek inferred ⁵⁴	15995322
10	NGF	Nerve Growth Factor	Protein Coding	5.25	DISEASES inferred ¹⁵
11	LIPN	Lipase Family Member N	Protein Coding	5.21	DISEASES inferred ¹⁵

Sources

Variations for Myofascial Pain Syndrome

Sources

Expression for Myofascial Pain Syndrome

Search GEO for disease gene expression data for Myofascial Pain Syndrome.

Sources

Pathways for Myofascial Pain Syndrome

Pathways related to Myofascial Pain Syndrome according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Development Endothelin-1/EDNRA signaling ²³ Show member pathways Cytoskeleton remodeling FAK signaling ²³ Development Endothelin-1/EDNRA transactivation of EGFR ²³ GnRH signaling pathway ³⁶ Inflammatory mediator regulation of TRP channels ³⁶	11.51	TRPV1 NGF KNG1 ASIC3
2	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	11.34	TAC1 NGF BDNF
3	Trk receptor signaling mediated by PI3K and PLC-gamma ¹	10.66	TRPV1 NGF

Sources

GO Terms for Myofascial Pain Syndrome

Cellular components related to Myofascial Pain Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.63	TAC1 POMC NGF KNG1 CALCA BDNF
2	intrinsic component of plasma membrane	GO:0031226	9.26	TRPV1 PDGFRB
3	axon	GO:0030424	9.26	TAC1 NGF CALCA BDNF
4	extracellular region	GO:0005576	9.17	TAC1 POMC NGF LIPN KNG1 CALCA

Biological processes related to Myofascial Pain Syndrome according to GeneCards Suite gene sharing:

(show all 21)

#	Name	GO ID	Score	Top Affiliating Genes
1	G protein-coupled receptor signaling pathway	GO:0007186	9.98	TAC1 POMC PDGFRB KNG1 CALCA
2	inflammatory response	GO:0006954	9.83	TRPV1 TAC1 KNG1 CALCA
3	positive regulation of apoptotic process	GO:0043065	9.81	TRPV1 PDGFRB NGF KNG1
4	cell-cell signaling	GO:0007267	9.77	TAC1 POMC CALCA
5	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	9.72	PDGFRB NGF BDNF
6	neuropeptide signaling pathway	GO:0007218	9.63	TAC1 POMC CALCA
7	regulation of neuron differentiation	GO:0045664	9.59	NGF BDNF
8	peripheral nervous system development	GO:0007422	9.58	NGF BDNF
9	regulation of blood pressure	GO:0008217	9.58	TAC1 POMC CALCA
10	vasodilation	GO:0042311	9.57	KNG1 CALCA
11	neurotrophin TRK receptor signaling pathway	GO:0048011	9.56	NGF BDNF
12	nerve development	GO:0021675	9.54	NGF BDNF
13	response to heat	GO:0009408	9.54	TRPV1 CALCA ASIC3
14	nerve growth factor signaling pathway	GO:0038180	9.49	NGF BDNF
15	negative regulation of heart rate	GO:0010459	9.48	TRPV1 TAC1
16	positive regulation of cytosolic calcium ion concentration	GO:0007204	9.46	TRPV1 TAC1 KNG1 CALCA
17	positive regulation of collateral sprouting	GO:0048672	9.43	NGF BDNF
18	cellular response to nerve growth factor stimulus	GO:1990090	9.43	TRPV1 TAC1 CALCA
19	detection of chemical stimulus involved in sensory perception of pain	GO:0050968	9.32	TRPV1 ASIC3
20	response to pain	GO:0048265	9.13	TRPV1 TAC1 CALCA
21	detection of temperature stimulus involved in sensory perception of pain	GO:0050965	8.8	TRPV1 CALCA ASIC3

Molecular functions related to Myofascial Pain Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	signaling receptor binding	GO:0005102	9.1	POMC PDGFRB NGF KNG1 CALCA BDNF
2	nerve growth factor receptor binding	GO:0005163	8.96	NGF BDNF

Sources

Sources for Myofascial Pain Syndrome

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia