MCID: MYG005
MIFTS: 45

Myoglobinuria

Categories: Bone diseases, Genetic diseases, Metabolic diseases, Muscle diseases, Nephrological diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Myoglobinuria

Summaries for Myoglobinuria

Disease Ontology : 12 A myopathy that is characterized by an increased urinary excretion of myoglobin.

MalaCards based summary : Myoglobinuria is related to myoglobinuria, recurrent and genetic recurrent myoglobinuria. An important gene associated with Myoglobinuria is LPIN1 (Lipin 1), and among its related pathways/superpathways are Metabolism and Glucose metabolism. Affiliated tissues include kidney, bone and testes, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 Myoglobinuria is the presence of myoglobin in the urine, usually associated with rhabdomyolysis or... more...

Related Diseases for Myoglobinuria

Diseases in the Myoglobinuria family:

Myoglobinuria, Autosomal Dominant Myoglobinuria, Acute Recurrent, Autosomal Recessive
Myoglobinuria, Recurrent Myoglobinuria Dominant Form

Diseases related to Myoglobinuria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 myoglobinuria, recurrent 33.6 ACADVL CPT2 MT-CO1 PYGM
2 genetic recurrent myoglobinuria 33.3 LPIN1 MT-CO1 MT-CO3
3 phosphoglycerate kinase deficiency 32.2 PFKM PYGM
4 carnitine palmitoyltransferase ii deficiency, infantile 32.1 ACADVL CPT2
5 acyl-coa dehydrogenase, very long-chain, deficiency of 31.7 ACADVL CPT2
6 glycogen storage disease vii 31.7 PFKM PIK3C2A PYGM
7 glycogen storage disease v 31.5 CPT2 MB PFKM PYGM
8 gas gangrene 30.0 MB PIK3C2A
9 malignant hyperthermia 29.8 CPT2 MB PIK3C2A
10 neuroleptic malignant syndrome 29.8 MB PIK3C2A
11 myoglobinuria, acute recurrent, autosomal recessive 12.6
12 myoglobinuria, autosomal dominant 12.3
13 myoglobinuria dominant form 12.0
14 phosphoglycerate mutase deficiency 11.6
15 myopathy with lactic acidosis, hereditary 11.5
16 myopathy with deficiency of iron-sulfur cluster assembly enzyme 11.4
17 carnitine palmitoyltransferase ii deficiency, myopathic, stress-induced 11.3
18 fanconi-bickel syndrome 11.0
19 marinesco-sjogren syndrome 11.0
20 glycogen storage disease x 11.0
21 glycogen storage disease, type ixd 11.0
22 myopathy, autosomal recessive, with rigid spine and distal joint contractures 11.0
23 muscular phosphorylase kinase deficiency 11.0
24 myopathy 10.4
25 muscular dystrophy 10.3
26 hemoglobinuria 10.3
27 myocardial infarction 10.2
28 coenurosis 10.2 LDHA MT-CO1
29 epilepsy, familial temporal lobe, 2 10.2 MT-CO1 MT-CO3
30 leber optic atrophy 10.1 MT-CO1 MT-CO3
31 deafness, nonsyndromic sensorineural, mitochondrial 10.1 MT-CO1 MT-CO3
32 influenza 10.1
33 polymyositis 10.1
34 carnitine deficiency, systemic primary 10.1 ACADVL CPT2
35 myositis 10.1
36 acute myocardial infarction 10.1
37 hepatitis 10.1
38 hypokalemia 10.1
39 familial colorectal cancer 10.0 MT-CO1 MT-CO3
40 carnitine palmitoyltransferase i deficiency 10.0 ACADVL CPT2
41 subendocardial myocardial infarction 10.0 LDHA MB
42 muscular dystrophy, duchenne type 10.0
43 legionnaire disease 10.0
44 malaria 10.0
45 legionnaires' disease 10.0
46 legionellosis 10.0
47 respiratory failure 10.0
48 status epilepticus 10.0
49 pneumonia 10.0
50 neuropathy 10.0

Graphical network of the top 20 diseases related to Myoglobinuria:



Diseases related to Myoglobinuria

Symptoms & Phenotypes for Myoglobinuria

MGI Mouse Phenotypes related to Myoglobinuria:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.76 ACADVL CPT2 LDHA LPIN1 MB MT-CO1
2 homeostasis/metabolism MP:0005376 9.61 ACADVL CPT2 LDHA LPIN1 MB MT-CO1
3 muscle MP:0005369 9.1 ACADVL LPIN1 MB MT-CO1 PFKM PYGM

Drugs & Therapeutics for Myoglobinuria

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Near Infrared Spectroscopy in Patients Undergoing Robotic Assisted Laparoscopic Surgery in the Trendelenburg Position Unknown status NCT02829242
2 Incidence of Rhabdomyolysis Among Patients Admitted With Jimsonweed Ingestions Completed NCT00592657

Search NIH Clinical Center for Myoglobinuria

Cochrane evidence based reviews: myoglobinuria

Genetic Tests for Myoglobinuria

Genetic tests related to Myoglobinuria:

# Genetic test Affiliating Genes
1 Myoglobinuria 29

Anatomical Context for Myoglobinuria

MalaCards organs/tissues related to Myoglobinuria:

41
Kidney, Bone, Testes, Skeletal Muscle, Liver, Temporal Lobe

Publications for Myoglobinuria

Articles related to Myoglobinuria:

(show top 50) (show all 359)
# Title Authors Year
1
Myoglobinuria in two patients with Duchenne muscular dystrophy after treatment with zoledronate: a case-report and call for caution. ( 30217487 )
2018
2
Biblical myoglobinuria. ( 30133983 )
2018
3
An unusual case of gross myoglobinuria in a child following Russell's viper (Daboia russelii) envenomation. ( 30448288 )
2018
4
Primary Myoglobinuria: Differentiate Myoglobinuria from Hemoglobinuria. ( 28811700 )
2017
5
A novel PGK1 mutation associated with neurological dysfunction and the absence of episodes of hemolytic anemia or myoglobinuria. ( 28580215 )
2017
6
Young girl presenting with exercise-induced myoglobinuria. ( 27297959 )
2016
7
Recurrent episodes of myoglobinuria, mental retardation and seizures but no hemolysis in two brothers with phosphoglycerate kinase deficiency. ( 26883264 )
2016
8
Metabolic Myoglobinuria. ( 26319173 )
2015
9
Exercise Intolerance and Myoglobinuria Associated with a Novel Maternally Inherited MT-ND1 Mutation. ( 26108648 )
2015
10
Myoglobinuria as first clinical sign of a primary alpha-sarcoglycanopathy. ( 23989969 )
2014
11
Myoglobinuria masquerading as acute rejection in a renal allograft recipient with recurrent post transplant diabetic nephropathy. ( 24826952 )
2014
12
Recurrent myoglobinuria and deranged acylcarnitines due to a mutation in the mtDNA MT-CO2 gene. ( 23616164 )
2013
13
Influence of body mass loss and myoglobinuria on the development of muscle fatigue after a marathon in a warm environment. ( 23537020 )
2013
14
Severe falciparum malaria with dengue coinfection complicated by rhabdomyolysis and acute kidney injury: an unusual case with myoglobinemia, myoglobinuria but normal serum creatine kinase. ( 23256803 )
2012
15
Comparing the potential renal protective activity of desferrioxamine B and the novel chelator desferrioxamine B-N-(3-hydroxyadamant-1-yl)carboxamide in a cell model of myoglobinuria. ( 21320071 )
2011
16
Myoglobinuria and muscle pain are common in patients with limb-girdle muscular dystrophy 2I. ( 21220724 )
2011
17
Recurrent myoglobinuria in a sporadic patient with a novel mitochondrial DNA tRNA(Ile) mutation. ( 21324494 )
2011
18
Episodic myoglobinuria in a primary gamma-sarcoglycanopathy. ( 20356742 )
2010
19
Myoglobinuria after laparoscopic radiofrequency ablation of liver tumors. ( 20033345 )
2010
20
Necrotizing vacuolar myopathy presenting with recurrent myoglobinuria. ( 20942590 )
2010
21
Myoglobinuria in boys with Duchenne muscular dystrophy on corticosteroid therapy. ( 17719224 )
2008
22
Statin induced myopathy. Dipstick test for myoglobinuria. ( 19050020 )
2008
23
Myoglobinuria caused by exertional rhabdomyolysis misdiagnosed as psychiatric illness. ( 18172418 )
2008
24
Mutations in LPIN1 cause recurrent acute myoglobinuria in childhood. ( 18817903 )
2008
25
Exercise-induced cramp, myoglobinuria, and tubular aggregates in phosphoglycerate mutase deficiency. ( 16881065 )
2006
26
[Acute renal failure following convulsion-induced myoglobinuria]. ( 17052009 )
2006
27
Acute renal failure following kidney transplantation associated with myoglobinuria in patients treated with rapamycin. ( 16969287 )
2006
28
Intronic mutation in the PGK1 gene may cause recurrent myoglobinuria by aberrant splicing. ( 16567715 )
2006
29
Recurrent myoglobinuria due to carnitine palmitoyltransferase II deficiency: clinical, biochemical, and genetic features of adult-onset cases. ( 15776096 )
2005
30
Peripheral neuropathy, episodic myoglobinuria, and respiratory failure in deficiency of the mitochondrial trifunctional protein. ( 14694500 )
2004
31
Rhabdomyolysis, myoglobinuria, and necrotizing myopathies. ( 15474684 )
2004
32
Pathologic quiz case: a man with exertion-induced cramps and myoglobinuria. McArdle disease (glycogenosis type V or myophosphorylase deficiency). ( 12951997 )
2003
33
Myoglobinuria and COX deficiency in a patient taking cerivastatin and gemfibrozil. ( 12525734 )
2003
34
[Rhabdomyolysis and myoglobinuria]. ( 12799789 )
2003
35
A3 adenosine receptor knockout mice are protected against ischemia- and myoglobinuria-induced renal failure. ( 12388399 )
2003
36
Myoglobinuria: round up more than the usual suspects. ( 12584290 )
2003
37
Acute rhabdomyolysis and myoglobinuria associated with isotretinoin treatment. ( 12786885 )
2003
38
Genetic identity of Marinesco-Sjögren/myoglobinuria and CCFDN syndromes. ( 11805249 )
2002
39
Alpha-sarcoglycan deficiency featuring exercise intolerance and myoglobinuria. ( 12075495 )
2002
40
Primary beta-sarcoglycanopathy manifesting as recurrent exercise-induced myoglobinuria. ( 11369190 )
2001
41
Absence of myoglobinuria in acute psychotic patients with marked elevation in serum creatine phosphokinase level. ( 11313156 )
2001
42
Myoglobinuria and hypocalcemia after a superficial hydriodic acid burn. ( 11570535 )
2001
43
Myoglobinuria: evaluation of methods in the clinical diagnosis acute renal failure. ( 12026508 )
2001
44
Recurrent myoglobinuria due to a nonsense mutation in the COX I gene of mitochondrial DNA. ( 10980727 )
2000
45
Novel mutation in the CPT II gene in a child with periodic febrile myalgia and myoglobinuria. ( 10868782 )
2000
46
Myoglobinuria: a cause of acute renal failure in alcoholic hepatitis. ( 11151932 )
2000
47
Myoglobinuria. ( 10658177 )
2000
48
Myoglobinuria after ingestion of extracts of guarana, Ginkgo biloba and kava. ( 10938194 )
2000
49
Unsuspected child abuse revealed by delayed presentation of periportal tracking and myoglobinuria. ( 10963553 )
2000
50
Acute renal failure from myoglobinuria secondary to myositis from severe falciparum malaria. ( 10970990 )
2000

Variations for Myoglobinuria

Expression for Myoglobinuria

Search GEO for disease gene expression data for Myoglobinuria.

Pathways for Myoglobinuria

GO Terms for Myoglobinuria

Cellular components related to Myoglobinuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.86 ACADVL LDHA LPIN1 MB PFKM PGAM2
2 mitochondrial inner membrane GO:0005743 9.46 ACADVL CPT2 MT-CO1 MT-CO3
3 mitochondrial respiratory chain complex IV GO:0005751 8.96 MT-CO1 MT-CO3
4 respiratory chain complex IV GO:0045277 8.62 MT-CO1 MT-CO3

Biological processes related to Myoglobinuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fatty acid metabolic process GO:0006631 9.5 ACADVL CPT2 LPIN1
2 response to hydrogen peroxide GO:0042542 9.46 LDHA MB
3 fatty acid beta-oxidation GO:0006635 9.43 ACADVL CPT2
4 aerobic respiration GO:0009060 9.4 MT-CO1 MT-CO3
5 canonical glycolysis GO:0061621 9.37 PFKM PGAM2
6 fatty acid catabolic process GO:0009062 9.26 ACADVL LPIN1
7 mitochondrial electron transport, cytochrome c to oxygen GO:0006123 9.16 MT-CO1 MT-CO3
8 glycogen catabolic process GO:0005980 8.96 PFKM PYGM
9 glycolytic process GO:0006096 8.8 LDHA PFKM PGAM2

Molecular functions related to Myoglobinuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 catalytic activity GO:0003824 9.13 LDHA PFKM PYGM
2 cytochrome-c oxidase activity GO:0004129 8.62 MT-CO1 MT-CO3

Sources for Myoglobinuria

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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