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MCID: MYG005
MIFTS: 44

Myoglobinuria

Categories: Bone diseases, Genetic diseases, Metabolic diseases, Muscle diseases, Nephrological diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Myoglobinuria

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MalaCards integrated aliases for Myoglobinuria:

Name: Myoglobinuria 12 74 43 15 39 32

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases Metabolic diseases
Anatomical: Muscle diseases Nephrological diseases Neuronal diseases Bone diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:0080108
MeSH 43 D009212
ICD10 32 R82.1
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Summaries for Myoglobinuria

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Disease Ontology : 12 A myopathy that is characterized by an increased urinary excretion of myoglobin.

MalaCards based summary : Myoglobinuria is related to genetic recurrent myoglobinuria and myoglobinuria, recurrent. An important gene associated with Myoglobinuria is LPIN1 (Lipin 1), and among its related pathways/superpathways are Metabolism and Glycosaminoglycan metabolism. The drugs Acetylcysteine and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and skeletal muscle, and related phenotypes are Decreased viability after gemcitabine stimulation and homeostasis/metabolism

Wikipedia : 74 Myoglobinuria is the presence of myoglobin in the urine, usually associated with rhabdomyolysis or... more...

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Related Diseases for Myoglobinuria

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Diseases in the Myoglobinuria family:

Myoglobinuria, Autosomal Dominant Myoglobinuria, Acute Recurrent, Autosomal Recessive
Myoglobinuria, Recurrent

Diseases related to Myoglobinuria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 175)
# Related Disease Score Top Affiliating Genes
1 genetic recurrent myoglobinuria 34.3 MT-CO3 MT-CO1 LPIN1
2 myoglobinuria, recurrent 34.2 PYGM MT-CO1 DMD CPT2 ACADVL
3 acyl-coa dehydrogenase, very long-chain, deficiency of 32.8 HADH CPT2 ACADVL
4 carnitine palmitoyltransferase ii deficiency, infantile 32.4 HADH CPT2 AMPD1 ACADVL
5 glycogen storage disease vii 32.3 PYGM PGAM2 PFKM AMPD3 AMPD1
6 glycogen storage disease v 31.6 PYGM PHKA1 PGAM2 PFKM MB CPT2
7 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 31.2 PIK3C2A PFKM MB CPT2 ACADVL
8 acute kidney failure 31.2 PIK3C2A MB GPT CPT2
9 gas gangrene 30.6 PIK3C2A MB DMD
10 mitochondrial trifunctional protein deficiency 30.5 HADH CPT2 ACADVL
11 compartment syndrome 30.4 PIK3C2A MB GPT
12 metabolic myopathy 30.4 PGAM2 MB AMPD1
13 neuroleptic malignant syndrome 30.3 PIK3C2A MB GPT
14 pyomyositis 30.3 PIK3C2A MB
15 3-hydroxyacyl-coa dehydrogenase deficiency 30.2 HADH ACADVL
16 atrial standstill 1 30.2 DMD CPT2 ACADVL
17 mitochondrial complex iv deficiency 30.1 PYGM MT-CO3 MT-CO1
18 mitochondrial metabolism disease 30.1 PFKM MT-CYB MT-CO3 MT-CO1 CPT2
19 creatine phosphokinase, elevated serum 30.1 PIK3C2A MB DMD
20 kearns-sayre syndrome 30.1 PYGM MT-CYB MT-CO3 MT-CO1
21 mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes 30.0 MT-CYB MT-CO3 MT-CO1 AMPD1
22 optic nerve disease 29.9 MT-CYB MT-CO3 MT-CO1
23 respiratory failure 29.9 PIK3C2A GPT DMD CPT2 ACADVL
24 disseminated intravascular coagulation 29.9 PIK3C2A MB GPT
25 muscular disease 29.8 PIK3C2A MB DMD
26 malignant hyperthermia 29.6 PYGM PIK3C2A MB GPT DMD CPT2
27 multiple acyl-coa dehydrogenase deficiency 29.6 PYGM HADH CPT2 AMPD1 ACADVL
28 glycogen storage disease 29.1 PYGM PHKA1 PGAM2 PFKM MB LDHA
29 myopathy 28.6 PYGM PIK3C2A PGK1 PGAM2 PFKM MT-CYB
30 myoglobinuria, acute recurrent, autosomal recessive 12.7
31 myoglobinuria, autosomal dominant 12.5
32 myopathy with deficiency of iron-sulfur cluster assembly enzyme 11.8
33 carnitine palmitoyltransferase ii deficiency, myopathic, stress-induced 11.8
34 myopathy with lactic acidosis, hereditary 11.7
35 phosphoglycerate kinase 1 deficiency 11.7
36 phosphorylase kinase deficiency 11.7
37 glycogen storage disease x 11.5
38 dystrophinopathies 11.5
39 marinesco-sjogren syndrome 11.4
40 congenital cataracts, facial dysmorphism, and neuropathy 11.4
41 fanconi-bickel syndrome 11.1
42 glycogen storage disease, type ixd 11.1
43 brody myopathy 11.1
44 lactate dehydrogenase deficiency 11.1
45 muscular phosphorylase kinase deficiency 11.1
46 kidney disease 10.8
47 muscular dystrophy 10.5
48 pediculus humanus capitis infestation 10.4 MT-CYB MT-CO1
49 hemoglobinuria 10.4
50 mixed malaria 10.4 MT-CYB MT-CO3

Graphical network of the top 20 diseases related to Myoglobinuria:



Diseases related to Myoglobinuria
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Symptoms & Phenotypes for Myoglobinuria

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GenomeRNAi Phenotypes related to Myoglobinuria according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability after gemcitabine stimulation GR00107-A-2 8.8 PFKM PHKA1 PIK3C2A

MGI Mouse Phenotypes related to Myoglobinuria:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.8 ACADVL AMPD1 AMPD3 CPT2 DMD HADH
2 muscle MP:0005369 9.28 ACADVL AMPD1 DMD LPIN1 MB MT-CO1
Sources

Drugs & Therapeutics for Myoglobinuria

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Drugs for Myoglobinuria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 2, Phase 3 616-91-1 12035
2 Anti-Infective Agents Phase 2, Phase 3
3 Respiratory System Agents Phase 2, Phase 3
4 Antidotes Phase 2, Phase 3
5 Antiviral Agents Phase 2, Phase 3
6 Antioxidants Phase 2, Phase 3
7 Expectorants Phase 2, Phase 3
8 Protective Agents Phase 2, Phase 3
9 N-monoacetylcystine Phase 2, Phase 3
10
Valproic acid Approved, Investigational Phase 2 99-66-1 3121
11
Bezafibrate Approved, Investigational Phase 2 41859-67-0 39042
12 Psychotropic Drugs Phase 2
13 Neurotransmitter Agents Phase 2
14 Anticonvulsants Phase 2
15 Hypolipidemic Agents Phase 2
16 Lipid Regulating Agents Phase 2
17 Antimetabolites Phase 2
18
tannic acid Approved 1401-55-4
19
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
20
Atorvastatin Approved 134523-00-5 60823
21
Hydroxychloroquine Approved 118-42-3 3652
22 Hydroxymethylglutaryl-CoA Reductase Inhibitors
23 Anticholesteremic Agents
24 Antiprotozoal Agents
25 Antiparasitic Agents
26 Antirheumatic Agents
27 Antimalarials

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 N-Acetylcysteine in Critically Ill Patients Undergoing Contrast Enhanced Computed Tomography: A Randomized Trial Completed NCT00830193 Phase 2, Phase 3 N-acetylcysteine;D5W Placebo
2 A Phase II Pilot Study to Explore Treatment With Sodium Valproate in Adults With McArdle Disease (Glycogen Storage Disorder Type V, GSDV) Completed NCT03112889 Phase 2 Sodium Valproate
3 Evaluation of the Effect of Bezafibrate on Muscle Metabolism During Exercise in Patients With CPTII and VLCAD Deficiency Completed NCT00983788 Phase 2 Bezafibrate
4 Triheptanoin's Effect on Fatty Acid Oxidation and Exercise Tolerance in Patients With Debrancher Deficiency, Glycogenin-1 Deficiency and Phosphofructoinase Deficiency at Rest and During Exercise. A Randomized, Double-blind, Placebo-controlled, Cross-over Study Recruiting NCT03642860 Phase 2 Triheptanoin;Placebo Oil
5 Near Infrared Spectroscopy for Determination of Tissue Oxygenation in Patients Undergoing Robotic Assisted Laparoscopic Surgery in the Trendelenburg Position - A Feasibility Study Unknown status NCT02829242
6 Incidence of Rhabdomyolysis Among Pediatric and Adolescent Patients Admitted for Jimsonweed (Datura Stramonium) Ingestions Completed NCT00592657
7 Ketogenic Diet in McArdle Disease: a Multicentric Single Blind Controlled Trial Recruiting NCT04292938
8 The Effect of Seven-Day Atorvastatin Administration on Emotional Processing, Reward Processing, and Inflammation in Healthy Volunteers Recruiting NCT03966859 Atorvastatin 20mg
9 Acute Rhabdomyolysis and Muscle Pain Associated With Mutations in the LPIN1 Gene - A Retrospective Study Describing the Safety and Efficacy of Hydroxychloroquine Sulfate Given on a Compassionate Basis to Patients Suffering From Lipin-1 Deficiency Not yet recruiting NCT04007562 Hydroxychloroquine Sulfate

Search NIH Clinical Center for Myoglobinuria

Cochrane evidence based reviews: myoglobinuria

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Genetic Tests for Myoglobinuria

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Anatomical Context for Myoglobinuria

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MalaCards organs/tissues related to Myoglobinuria:

40
Kidney, Testes, Skeletal Muscle, Liver, Spinal Cord, Brain, Heart
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Publications for Myoglobinuria

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Articles related to Myoglobinuria:

(show top 50) (show all 1422)
# Title Authors PMID Year
1
Rhabdomyolysis. 61
32532456 2020
2
Analysis of the Safety and Efficacy of the Endovascular Treatment for Acute Limb Ischemia with Percutaneous Pharmacomechanical Thrombectomy Compared with Catheter-Directed Thrombolysis. 61
31863953 2020
3
Case Report: A COVID-19 Patient Presenting with Mild Rhabdomyolysis. 61
32563271 2020
4
Renal disorders in rheumatologic diseases: the spectrum is changing (Part 1: connective tissue diseases). 61
32529559 2020
5
Statin-Induced Immune-Mediated Necrotizing Myopathy: An Increasingly Recognized Inflammatory Myopathy. 61
32523820 2020
6
Systemic lupus erythematosus and hydroxychloroquine-related acute intermittent porphyria. 61
31865445 2020
7
Extremely High Creatine Kinase Activity in Rhabdomyolysis without Acute Kidney Injury. 61
32430491 2020
8
Rhabdomyolysis in a patient with McArdle's disease. 61
32376148 2020
9
Effects of bodybuilding supplements on the kidney: A population-based incidence study of biopsy pathology and clinical characteristics among middle eastern men. 61
32375656 2020
10
Muscle Carnitine Palmitoyltransferase II (CPT II) Deficiency: A Conceptual Approach. 61
32295037 2020
11
[Rhabdomyolysis: have you considered food poisoning from quails?] 61
32281758 2020
12
Severe Rhabdomyolysis in Glucose-6-Phosphate Dehydrogenase Deficiency. 61
32448501 2020
13
A systematic review on the definition of rhabdomyolysis. 61
30617905 2020
14
Histopathological kidney changes and myoglobinuria in neotropical non-human primates attacked by dogs, Brazil. 61
31885097 2020
15
Repeatedly in Rhabdomyolysis. 61
32205805 2020
16
Systemic AAV8-mediated delivery of a functional copy of muscle glycogen phosphorylase (Pygm) ameliorates disease in a murine model of McArdle disease. 61
31511858 2020
17
Oxygen embolism after hydrogen peroxide irrigation during hip arthroscopy: a case report. 61
32000742 2020
18
Complications and Outcome of Electrical Burns in Manipal, India: 6-Year Institutional Report. 61
32190586 2020
19
Fever, Fasting, and Rhabdomyolysis in an Adult Male. 61
32129275 2020
20
Severe Rhabdomyolysis Associated with Acute Amphetamine Toxicosis in a Dog. 61
32082692 2020
21
Cytosorb for Management of Acute Kidney Injury due to Rhabdomyolysis in a Child. 61
31729332 2019
22
Value and Use of Urinalysis for Myoglobinuria. 61
31116043 2019
23
Current and emerging therapies in Becker muscular dystrophy (BMD). 61
31788661 2019
24
Rhabdomyolysis and myoglobinuria following bisphosphonate infusion in patients with Duchenne muscular dystrophy. 61
31213343 2019
25
Neuron-specific knockdown of Drosophila HADHB induces a shortened lifespan, deficient locomotive ability, abnormal motor neuron terminal morphology and learning disability. 61
30953623 2019
26
Muscle soreness and rhabdomyolysis. 61
31238673 2019
27
A voltage-based analysis of fluid delivery and outcomes in burn patients with electrical injuries over a 6-year period. 61
30935702 2019
28
The current status of malignant hyperthermia. 61
32305961 2019
29
Severe acute kidney injury owing to rhabdomyolysis and intravascular haemolysis in an 11-year-old child with G6PD deficiency. 61
29493437 2019
30
Alcohol Withdrawal Mimicking Neuroleptic Malignant Syndrome. 61
31338272 2019
31
[Carnitin-Palmitoyl Transferase type 2 deficiency: a rare cause of acute renal failure due to rhabdomyolysis]. 61
30983179 2019
32
Update: Exertional rhabdomyolysis, active component, U.S. Armed Forces, 2014-2018. 61
31026174 2019
33
Presumed Malignant Hyperthermia Treated During Cardiopulmonary Bypass in a Pediatric Patient Undergoing Aortic Valve Replacement: A Case Report. 61
30299295 2019
34
Purple urine bag syndrome. 61
30917642 2019
35
Exercise in Glucose-6-Phosphate Dehydrogenase Deficiency: Harmful or Harmless? A Narrative Review. 61
31089417 2019
36
Late and Severe Myopathy in a Patient With Glycogenosis VII Worsened by Cyclosporine and Amiodarone. 61
30792690 2019
37
Unrecognized High Occurrence of Genetically Confirmed Hereditary Carnitine Palmitoyltransferase II Deficiency in an Austrian Family Points to the Ongoing Underdiagnosis of the Disease. 61
31191612 2019
38
To absorb fat - supersize my lipid droplets. 61
30507609 2019
39
A Hemizygous Deletion Within the PGK1 Gene in Males with PGK1 Deficiency. 61
30570712 2019
40
Combined HIIT and Resistance Training in Very Long-Chain Acyl-CoA Dehydrogenase Deficiency: A Case Report. 61
31191348 2019
41
An unusual case of gross myoglobinuria in a child following Russell's viper (Daboia russelii) envenomation. 61
30448288 2019
42
Rhabdomyolysis observed at forensic autopsy: a series of 52 cases. 61
30056625 2018
43
Novel heterozygous mutations in the PGAM2 gene with negative exercise testing. 61
30310767 2018
44
Acute kidney injury secondary to traumatic rhabdomyolysis in a dog. 61
30222253 2018
45
Propofol infusion-like syndrome in a dog. 61
30410181 2018
46
Acute Limb Ischemia. 61
30243449 2018
47
Myoglobinuria in two patients with Duchenne muscular dystrophy after treatment with zoledronate: a case-report and call for caution. 61
30217487 2018
48
Electrical burn injury: a comparison of outcomes of high voltage versus low voltage injury in an Indian scenario. 61
30863247 2018
49
Level of residual enzyme activity modulates the phenotype in phosphoglycerate kinase deficiency. 61
30111548 2018
50
Biblical myoglobinuria. 61
30133983 2018
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Variations for Myoglobinuria

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Expression for Myoglobinuria

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Search GEO for disease gene expression data for Myoglobinuria.
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Pathways for Myoglobinuria

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Pathways related to Myoglobinuria according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Metabolism 65
Show member pathways
 13.23 PYGM PIK3C2A PHKA1 PGK1 PGAM2 PGAM1
2
Glycosaminoglycan metabolism 65
Show member pathways
 12.63 PYGM PHKA1 PGK1 PGAM2 PGAM1 PFKM
3
Glucose metabolism 65
Show member pathways
 12.38 PYGM PHKA1 PGK1 PGAM2 PGAM1 PFKM
4
Glucose / Energy Metabolism 4
12.33 PGAM1 MB LPIN1 LDHA
5
Fatty Acyl-CoA Biosynthesis 65
Show member pathways
 12.25 LPIN1 HADH CPT2 ACADVL
6
Carbon metabolism 36
Show member pathways
 12.09 PGK1 PGAM2 PGAM1 PFKM GPT
7
HIF-1 signaling pathway 36
11.74 PGK1 PFKM LDHA
8
Citrate cycle (TCA cycle) 36
Show member pathways
 11.7 PGK1 PGAM2 PFKM
9
Cardiac muscle contraction 36
11.59 MT-CYB MT-CO3 MT-CO1
10
Central carbon metabolism in cancer 36
11.47 PGAM2 PGAM1 PFKM LDHA
11
Glucagon signaling pathway 36
11.46 PYGM PHKA1 PGAM2 PGAM1 PFKM LDHA
12
Mitochondrial LC-Fatty Acid Beta-Oxidation 1
Show member pathways
 11.33 HADH CPT2 ACADVL
13
Cori Cycle 1
10.66 PGK1 PGAM1 LDHA GPT
14
Effects of Nitric Oxide 1
10.36 MT-CO1 MB
Sources

GO Terms for Myoglobinuria

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Cellular components related to Myoglobinuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.92 PYGM PIK3C2A PGK1 PGAM2 PGAM1 MB
2 cytosol GO:0005829 9.5 PYGM PIK3C2A PHKA1 PGK1 PGAM2 PGAM1
3 mitochondrial inner membrane GO:0005743 9.35 MT-CYB MT-CO3 MT-CO1 CPT2 ACADVL
4 mitochondrial respiratory chain complex III GO:0005750 9.26 MT-CYB MT-CO1
5 respiratory chain complex IV GO:0045277 9.16 MT-CO3 MT-CO1

Biological processes related to Myoglobinuria according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 10.01 MT-CYB MT-CO3 MT-CO1 LDHA HADH ACADVL
2 fatty acid metabolic process GO:0006631 9.78 LPIN1 HADH CPT2 ACADVL
3 positive regulation of cold-induced thermogenesis GO:0120162 9.74 LPIN1 HADH CPT2
4 response to hormone GO:0009725 9.67 MT-CYB MB HADH
5 fatty acid beta-oxidation GO:0006635 9.61 HADH CPT2 ACADVL
6 muscle cell cellular homeostasis GO:0046716 9.6 PFKM DMD
7 mitochondrial electron transport, cytochrome c to oxygen GO:0006123 9.59 MT-CO3 MT-CO1
8 response to copper ion GO:0046688 9.58 MT-CYB MT-CO1
9 purine ribonucleoside monophosphate biosynthetic process GO:0009168 9.58 AMPD3 AMPD1
10 gluconeogenesis GO:0006094 9.58 PGK1 PGAM2 PGAM1
11 fatty acid catabolic process GO:0009062 9.56 LPIN1 ACADVL
12 purine-containing compound salvage GO:0043101 9.55 AMPD3 AMPD1
13 response to mercury ion GO:0046689 9.52 PGAM2 MT-CYB
14 AMP metabolic process GO:0046033 9.51 AMPD3 AMPD1
15 electron transport coupled proton transport GO:0015990 9.46 MT-CYB MT-CO1
16 respiratory electron transport chain GO:0022904 9.43 MT-CYB MT-CO3 MT-CO1
17 IMP salvage GO:0032264 9.37 AMPD3 AMPD1
18 glycogen catabolic process GO:0005980 9.33 PYGM PHKA1 PFKM
19 IMP biosynthetic process GO:0006188 9.32 AMPD3 AMPD1
20 canonical glycolysis GO:0061621 9.26 PGK1 PGAM2 PGAM1 PFKM
21 glycolytic process GO:0006096 9.02 PGK1 PGAM2 PGAM1 PFKM LDHA

Molecular functions related to Myoglobinuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.8 MT-CYB MT-CO3 MT-CO1 LDHA HADH ACADVL
2 intramolecular transferase activity, phosphotransferases GO:0016868 9.4 PGAM2 PGAM1
3 deaminase activity GO:0019239 9.37 AMPD3 AMPD1
4 phosphoglycerate mutase activity GO:0004619 9.26 PGAM2 PGAM1
5 catalytic activity GO:0003824 9.17 PYGM PHKA1 PGAM2 PGAM1 PFKM LDHA
6 bisphosphoglycerate mutase activity GO:0004082 9.16 PGAM2 PGAM1
7 AMP deaminase activity GO:0003876 8.96 AMPD3 AMPD1
Sources

Sources for Myoglobinuria

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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