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MCID: MYG005
MIFTS: 43

Myoglobinuria

Categories: Bone diseases, Genetic diseases, Metabolic diseases, Muscle diseases, Nephrological diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Myoglobinuria

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MalaCards integrated aliases for Myoglobinuria:

Name: Myoglobinuria 12 75 44 15 40 33

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases Metabolic diseases
Anatomical: Muscle diseases Nephrological diseases Neuronal diseases Bone diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:0080108
MeSH 44 D009212
ICD10 33 R82.1
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Summaries for Myoglobinuria

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Disease Ontology : 12 A myopathy that is characterized by an increased urinary excretion of myoglobin.

MalaCards based summary : Myoglobinuria is related to genetic recurrent myoglobinuria and myoglobinuria, recurrent. An important gene associated with Myoglobinuria is LPIN1 (Lipin 1), and among its related pathways/superpathways are Metabolism and Glucose metabolism. The drugs Acetylcysteine and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and skeletal muscle, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 75 Myoglobinuria is the presence of myoglobin in the urine, usually associated with rhabdomyolysis or... more...

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Related Diseases for Myoglobinuria

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Diseases in the Myoglobinuria family:

Myoglobinuria, Autosomal Dominant Myoglobinuria, Acute Recurrent, Autosomal Recessive
Myoglobinuria, Recurrent

Diseases related to Myoglobinuria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
# Related Disease Score Top Affiliating Genes
1 genetic recurrent myoglobinuria 33.9 MT-CO3 MT-CO1 LPIN1
2 myoglobinuria, recurrent 33.6 PYGM MT-CO1 CPT2 ACADVL
3 phosphoglycerate kinase deficiency 33.0 PYGM PFKM
4 carnitine palmitoyltransferase ii deficiency, infantile 32.8 CPT2 ACADVL
5 acyl-coa dehydrogenase, very long-chain, deficiency of 32.8 CPT2 ACADVL
6 glycogen storage disease vii 32.4 PYGM PIK3C2A PFKM
7 glycogen storage disease v 31.6 PYGM PFKM MB CPT2
8 acute kidney failure 30.6 PIK3C2A MB
9 leber optic atrophy 30.3 MT-CO3 MT-CO1
10 gas gangrene 30.0 PIK3C2A MB
11 compartment syndrome 29.9 PIK3C2A MB
12 malignant hyperthermia 29.9 PIK3C2A MB CPT2
13 multiple acyl-coa dehydrogenase deficiency 29.8 CPT2 ACADVL
14 neuroleptic malignant syndrome 29.8 PIK3C2A MB
15 creatine phosphokinase, elevated serum 29.5 PIK3C2A MB
16 glycogen storage disease 29.0 PYGM PGAM2 PFKM LDHA
17 disseminated intravascular coagulation 28.9 PIK3C2A MB
18 muscular disease 28.6 PIK3C2A MB CPT2 ACADVL
19 myoglobinuria, acute recurrent, autosomal recessive 12.7
20 myoglobinuria, autosomal dominant 12.5
21 phosphoglycerate mutase deficiency 11.8
22 myopathy with deficiency of iron-sulfur cluster assembly enzyme 11.8
23 carnitine palmitoyltransferase ii deficiency, myopathic, stress-induced 11.7
24 myopathy with lactic acidosis, hereditary 11.7
25 phosphorylase kinase deficiency 11.7
26 myopathy 11.6
27 marinesco-sjogren syndrome 11.4
28 congenital cataracts, facial dysmorphism, and neuropathy 11.4
29 glycogen storage disease x 11.3
30 fanconi-bickel syndrome 11.1
31 glycogen storage disease, type ixd 11.1
32 brody myopathy 11.1
33 lactate dehydrogenase deficiency 11.1
34 muscular phosphorylase kinase deficiency 11.1
35 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.8
36 kidney disease 10.7
37 muscular dystrophy 10.5
38 coenurosis 10.5 MT-CO1 LDHA
39 hemoglobinuria 10.4
40 epilepsy, familial temporal lobe, 2 10.4 MT-CO3 MT-CO1
41 hypokalemia 10.3
42 polymyositis 10.3
43 deafness, nonsyndromic sensorineural, mitochondrial 10.3 MT-CO3 MT-CO1
44 carnitine deficiency, systemic primary 10.3 CPT2 ACADVL
45 acute kidney tubular necrosis 10.3
46 myositis 10.2
47 myocardial infarction 10.2
48 mitochondrial myopathy 10.2
49 influenza 10.2
50 muscular dystrophy, becker type 10.2

Graphical network of the top 20 diseases related to Myoglobinuria:



Diseases related to Myoglobinuria
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Symptoms & Phenotypes for Myoglobinuria

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MGI Mouse Phenotypes related to Myoglobinuria:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.76 ACADVL CPT2 LDHA LPIN1 MB MT-CO1
2 homeostasis/metabolism MP:0005376 9.61 ACADVL CPT2 LDHA LPIN1 MB MT-CO1
3 muscle MP:0005369 9.1 ACADVL LPIN1 MB MT-CO1 PFKM PYGM
Sources

Drugs & Therapeutics for Myoglobinuria

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Drugs for Myoglobinuria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 2, Phase 3 616-91-1 12035
2 Anti-Infective Agents Phase 2, Phase 3
3 N-monoacetylcystine Phase 2, Phase 3
4 Respiratory System Agents Phase 2, Phase 3
5 Free Radical Scavengers Phase 2, Phase 3
6 Antidotes Phase 2, Phase 3
7 Antioxidants Phase 2, Phase 3
8 Protective Agents Phase 2, Phase 3
9 Expectorants Phase 2, Phase 3
10 Antiviral Agents Phase 2, Phase 3
11
Valproic acid Approved, Investigational Phase 2 99-66-1 3121
12
Bezafibrate Approved, Investigational Phase 2 41859-67-0 39042
13 Tranquilizing Agents Phase 2
14 GABA Agents Phase 2
15 Antimanic Agents Phase 2
16 Neurotransmitter Agents Phase 2
17 Central Nervous System Depressants Phase 2
18 Anticonvulsants Phase 2
19 Psychotropic Drugs Phase 2
20 Lipid Regulating Agents Phase 2
21 Hypolipidemic Agents Phase 2
22 Antimetabolites Phase 2
23
Atorvastatin Approved 134523-00-5 60823
24
Hydroxychloroquine Approved 118-42-3 3652
25 Hydroxymethylglutaryl-CoA Reductase Inhibitors
26 Anticholesteremic Agents
27 Antiparasitic Agents
28 Antimalarials
29 Antiprotozoal Agents
30 Antirheumatic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 N-Acetylcysteine in Critically Ill Patients Undergoing Contrast Enhanced Computed Tomography: A Randomized Trial Completed NCT00830193 Phase 2, Phase 3 N-acetylcysteine;D5W Placebo
2 A Phase II Pilot Study to Explore Treatment With Sodium Valproate in Adults With McArdle Disease (Glycogen Storage Disorder Type V, GSDV) Completed NCT03112889 Phase 2 Sodium Valproate
3 Evaluation of the Effect of Bezafibrate on Muscle Metabolism During Exercise in Patients With CPTII and VLCAD Deficiency Completed NCT00983788 Phase 2 Bezafibrate
4 Triheptanoin's Effect on Fatty Acid Oxidation and Exercise Tolerance in Patients With Debrancher Deficiency, Glycogenin-1 Deficiency and Phosphofructoinase Deficiency at Rest and During Exercise. A Randomized, Double-blind, Placebo-controlled, Cross-over Study Recruiting NCT03642860 Phase 2 Triheptanoin;Placebo Oil
5 Near Infrared Spectroscopy for Determination of Tissue Oxygenation in Patients Undergoing Robotic Assisted Laparoscopic Surgery in the Trendelenburg Position - A Feasibility Study Unknown status NCT02829242
6 Incidence of Rhabdomyolysis Among Pediatric and Adolescent Patients Admitted for Jimsonweed (Datura Stramonium) Ingestions Completed NCT00592657
7 Biomarker for Duchenne Disease AN INTERNATIONAL, MULTICENTER, EPIDEMIOLOGICAL PROTOCOL Recruiting NCT02994030
8 The Effect of Seven-Day Atorvastatin Administration on Emotional Processing, Reward Processing, and Inflammation in Healthy Volunteers Recruiting NCT03966859 Atorvastatin 20mg
9 Acute Rhabdomyolysis and Muscle Pain Associated With Mutations in the LPIN1 Gene - A Retrospective Study Describing the Safety and Efficacy of Hydroxychloroquine Sulfate Given on a Compassionate Basis to Patients Suffering From Lipin-1 Deficiency Not yet recruiting NCT04007562 Hydroxychloroquine Sulfate

Search NIH Clinical Center for Myoglobinuria

Cochrane evidence based reviews: myoglobinuria

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Genetic Tests for Myoglobinuria

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Anatomical Context for Myoglobinuria

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MalaCards organs/tissues related to Myoglobinuria:

41
Kidney, Testes, Skeletal Muscle, Liver, Spinal Cord, Brain, Heart
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Publications for Myoglobinuria

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Articles related to Myoglobinuria:

(show top 50) (show all 1400)
# Title Authors PMID Year
1
Rhabdomyolysis and myoglobinuria following bisphosphonate infusion in patients with Duchenne muscular dystrophy. 38
31213343 2019
2
Muscle soreness and rhabdomyolysis. 38
31238673 2019
3
A voltage-based analysis of fluid delivery and outcomes in burn patients with electrical injuries over a 6-year period. 38
30935702 2019
4
Neuron-specific knockdown of Drosophila HADHB induces a shortened lifespan, deficient locomotive ability, abnormal motor neuron terminal morphology and learning disability. 38
30953623 2019
5
Value and Use of Urinalysis for Myoglobinuria. 38
31116043 2019
6
Severe acute kidney injury owing to rhabdomyolysis and intravascular haemolysis in an 11-year-old child with G6PD deficiency. 38
29493437 2019
7
Alcohol Withdrawal Mimicking Neuroleptic Malignant Syndrome. 38
31338272 2019
8
Update: Exertional rhabdomyolysis, active component, U.S. Armed Forces, 2014-2018. 38
31026174 2019
9
[Carnitin-Palmitoyl Transferase type 2 deficiency: a rare cause of acute renal failure due to rhabdomyolysis]. 38
30983179 2019
10
Presumed Malignant Hyperthermia Treated During Cardiopulmonary Bypass in a Pediatric Patient Undergoing Aortic Valve Replacement: A Case Report. 38
30299295 2019
11
Purple urine bag syndrome. 38
30917642 2019
12
Unrecognized High Occurrence of Genetically Confirmed Hereditary Carnitine Palmitoyltransferase II Deficiency in an Austrian Family Points to the Ongoing Underdiagnosis of the Disease. 38
31191612 2019
13
A systematic review on the definition of rhabdomyolysis. 38
30617905 2019
14
A Hemizygous Deletion Within the PGK1 Gene in Males with PGK1 Deficiency. 38
30570712 2019
15
Combined HIIT and Resistance Training in Very Long-Chain Acyl-CoA Dehydrogenase Deficiency: A Case Report. 38
31191348 2019
16
An unusual case of gross myoglobinuria in a child following Russell's viper (Daboia russelii) envenomation. 38
30448288 2019
17
To absorb fat - supersize my lipid droplets. 38
30507609 2019
18
Late and Severe Myopathy in a Patient With Glycogenosis VII Worsened by Cyclosporine and Amiodarone. 38
30792690 2019
19
Exercise in Glucose-6-Phosphate Dehydrogenase Deficiency: Harmful or Harmless? A Narrative Review. 38
31089417 2019
20
Novel heterozygous mutations in the PGAM2 gene with negative exercise testing. 38
30310767 2018
21
Rhabdomyolysis observed at forensic autopsy: a series of 52 cases. 38
30056625 2018
22
Acute kidney injury secondary to traumatic rhabdomyolysis in a dog. 38
30222253 2018
23
Propofol infusion-like syndrome in a dog. 38
30410181 2018
24
Acute Limb Ischemia. 38
30243449 2018
25
Myoglobinuria in two patients with Duchenne muscular dystrophy after treatment with zoledronate: a case-report and call for caution. 38
30217487 2018
26
Level of residual enzyme activity modulates the phenotype in phosphoglycerate kinase deficiency. 38
30111548 2018
27
Electrical burn injury: a comparison of outcomes of high voltage versus low voltage injury in an Indian scenario. 38
30863247 2018
28
Biblical myoglobinuria. 38
30133983 2018
29
Double-positive with positive anti-glomerular basement membrane antibody and ANCA-positive disease in a patient with dermatomyositis. 38
30042104 2018
30
Outcome of Benign Acute Childhood Myositis: The Experience of 2 Large Tertiary Care Pediatric Hospitals. 38
29851916 2018
31
Recurrent rhabdomyolysis caused by carnitine palmitoyltransferase II deficiency, common but under-recognised: Lessons to be learnt. 38
29744303 2018
32
TREATMENT OF SUSPECTED EXERTIONAL MYOPATHY USING DANTROLENE IN A COYOTE ( CANIS LATRANS). 38
29900791 2018
33
McArdle's disease: A differential diagnosis of idiopathic toe walking. 38
29881221 2018
34
Electrical Burns and Their Treatment in a Tertiary Hospital in Albania. 38
29875855 2018
35
Carnitine Palmitoyltransferase II Deficiency (CPT II) Followed By Rhabdomyolysis and Acute Kidney Injury. 38
29731937 2018
36
Exercise-Induced Abdominal Wall Muscle Injury Resulting in Rhabdomyolysis and Mimicking an Acute Abdomen. 38
29420397 2018
37
Case 251: Nontraumatic Drug-associated Rhabdomyolysis of Head and Neck Muscles. 38
29461948 2018
38
Local morbidity from red-bellied black snake (Pseudechis porphyriacus, Elapidae) envenoming: Two cases and a brief review of management. 38
29269114 2018
39
Mutations in GMPPB Presenting with Pseudometabolic Myopathy. 38
28456886 2018
40
Nontraumatic Exertional Rhabdomyolysis Leading to Acute Kidney Injury in a Sickle Trait Positive Individual on Renal Biopsy. 38
29850311 2018
41
TANGO2-Related Metabolic Encephalopathy and Arrhythmias 38
29369572 2018
42
Acute polyneuromyopathy with respiratory failure secondary to monensin intoxication in a dog. 38
29210488 2018
43
Exercise-induced acute renal failure in a trainee cyclist without hypouricemia: Successful athletic career post-treatment. 38
29264080 2017
44
McArdle disease: a "pediatric" disorder presenting in an adult with acute kidney injury. 38
28660497 2017
45
Patients with glycogen storage diseases undergoing anesthesia: a case series. 38
28985713 2017
46
Rhabdomyolysis and compartment syndrome in a bodybuilder undergoing minimally invasive cardiac surgery. 38
28994685 2017
47
Treatment Opportunities in Patients With Metabolic Myopathies. 38
28932990 2017
48
Clinics in diagnostic imaging (179). Severe rhabdomyolysis complicated by myonecrosis. 38
28848989 2017
49
Primary Myoglobinuria: Differentiate Myoglobinuria from Hemoglobinuria. 38
28811700 2017
50
Viral myositis in children. 38
28500193 2017
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Variations for Myoglobinuria

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Expression for Myoglobinuria

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Search GEO for disease gene expression data for Myoglobinuria.
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Pathways for Myoglobinuria

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Pathways related to Myoglobinuria according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Metabolism 66
Show member pathways
 12.97 PYGM PIK3C2A PGAM2 PFKM MT-CO3 MT-CO1
2
Glucose metabolism 66
Show member pathways
 12.2 PYGM PGAM2 PFKM LDHA
3
Glucose / Energy Metabolism 4
12.07 MB LPIN1 LDHA
4
Glucagon signaling pathway 37
11.46 PYGM PGAM2 LDHA
5
Mitochondrial LC-Fatty Acid Beta-Oxidation 1
Show member pathways
 11.09 CPT2 ACADVL
6
Central carbon metabolism in cancer 37
10.97 PGAM2 PFKM LDHA
7
Effects of Nitric Oxide 1
10.06 MT-CO1 MB
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GO Terms for Myoglobinuria

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Cellular components related to Myoglobinuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.86 PYGM PIK3C2A PGAM2 PFKM MB LPIN1
2 mitochondrial inner membrane GO:0005743 9.46 MT-CO3 MT-CO1 CPT2 ACADVL
3 mitochondrial respiratory chain complex IV GO:0005751 8.65 MT-CO1
4 respiratory chain complex IV GO:0045277 8.62 MT-CO3 MT-CO1

Biological processes related to Myoglobinuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fatty acid metabolic process GO:0006631 9.5 LPIN1 CPT2 ACADVL
2 response to hydrogen peroxide GO:0042542 9.46 MB LDHA
3 fatty acid beta-oxidation GO:0006635 9.43 CPT2 ACADVL
4 aerobic respiration GO:0009060 9.4 MT-CO3 MT-CO1
5 canonical glycolysis GO:0061621 9.37 PGAM2 PFKM
6 fatty acid catabolic process GO:0009062 9.26 LPIN1 ACADVL
7 mitochondrial electron transport, cytochrome c to oxygen GO:0006123 9.16 MT-CO3 MT-CO1
8 glycogen catabolic process GO:0005980 8.96 PYGM PFKM
9 glycolytic process GO:0006096 8.8 PGAM2 PFKM LDHA

Molecular functions related to Myoglobinuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 catalytic activity GO:0003824 9.13 PYGM PFKM LDHA
2 cytochrome-c oxidase activity GO:0004129 8.62 MT-CO3 MT-CO1
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Sources for Myoglobinuria

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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