MCID: MYG005
MIFTS: 40

Myoglobinuria

Categories: Genetic diseases, Infectious diseases, Metabolic diseases, Muscle diseases, Nephrological diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Myoglobinuria

Summaries for Myoglobinuria

Disease Ontology: 11 A myopathy that is characterized by an increased urinary excretion of myoglobin.

MalaCards based summary: Myoglobinuria is related to myoglobinuria, recurrent and genetic recurrent myoglobinuria. An important gene associated with Myoglobinuria is LPIN1 (Lipin 1), and among its related pathways/superpathways are Metabolism and Glycosaminoglycan metabolism. Affiliated tissues include kidney, skeletal muscle and spinal cord, and related phenotypes are Decreased viability after gemcitabine stimulation and muscle

Wikipedia: 75 Myoglobinuria is the presence of myoglobin in the urine, which usually results from rhabdomyolysis or... more...

Related Diseases for Myoglobinuria

Diseases in the Myoglobinuria family:

Myoglobinuria, Autosomal Dominant Myoglobinuria, Acute Recurrent, Autosomal Recessive
Myoglobinuria, Recurrent

Diseases related to Myoglobinuria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 232)
# Related Disease Score Top Affiliating Genes
1 myoglobinuria, recurrent 32.6 PYGM MT-CO1 CPT2 ACADVL
2 genetic recurrent myoglobinuria 32.3 MT-CO3 MT-CO1 LPIN1
3 acyl-coa dehydrogenase, very long-chain, deficiency of 32.0 HADH CPT2 ACADVL
4 carnitine palmitoyltransferase ii deficiency, infantile 31.7 HADH CPT2 AMPD1 ACADVL
5 glycogen storage disease vii 31.6 PYGM PGAM2 PFKM AMPD3 AMPD1
6 glycogen storage disease v 30.9 PYGM PHKA1 PGAM2 PFKM MB CPT2
7 acute kidney failure 30.9 PIK3C2A MB HP GPT CPT2
8 acute kidney tubular necrosis 30.7 PIK3C2A MB GPT
9 hypokalemia 30.7 PIK3C2A MB GPT
10 compartment syndrome 30.4 PIK3C2A MB GPT
11 mitochondrial complex iv deficiency, nuclear type 1 30.4 PYGM MT-CO3 MT-CO1
12 metabolic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 30.4 PIK3C2A MB
13 neuroleptic malignant syndrome 30.3 PIK3C2A MB GPT
14 mitochondrial trifunctional protein deficiency 30.3 HADH CPT2 ACADVL
15 malignant hyperthermia 30.3 PYGM PIK3C2A MB GPT CPT2 AMPD1
16 myopathy due to myoadenylate deaminase deficiency 30.2 AMPD3 AMPD1
17 pyomyositis 30.1 PIK3C2A MB
18 isolated cytochrome c oxidase deficiency 30.1 MT-CO3 MT-CO1
19 multiple acyl-coa dehydrogenase deficiency 30.0 HADH CPT2 AMPD1 ACADVL
20 carnitine deficiency, systemic primary 29.9 HADH CPT2 ACADVL
21 mitochondrial myopathy 29.9 PYGM MT-CYB MT-CO3 MT-CO1
22 disseminated intravascular coagulation 29.9 PIK3C2A MB GPT
23 isolated elevated serum creatine phosphokinase levels 29.5 PYGM PIK3C2A MB CPT2 AMPD1 ACADVL
24 endemic typhus 29.5 MT-CYB MT-CO1 GPT
25 epidemic typhus 29.5 MT-CYB MT-CO1 GPT
26 mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes 29.3 MT-CYB MT-CO3 MT-CO1 AMPD1
27 glycogen storage disease 29.1 PYGM PHKA1 PGAM2 PFKM LDHA CPT2
28 optic nerve disease 28.9 MT-CYB MT-CO3 MT-CO1
29 myopathy 28.0 PYGM PIK3C2A PHKA1 PGK1 PGAM2 PFKM
30 myoglobinuria, acute recurrent, autosomal recessive 11.6
31 myoglobinuria, autosomal dominant 11.4
32 myopathy with lactic acidosis, hereditary 11.4
33 glycogen storage disease x 11.3
34 carnitine palmitoyltransferase ii deficiency, myopathic, stress-induced 11.2
35 phosphoglycerate kinase 1 deficiency 11.1
36 fanconi-bickel syndrome 11.0
37 phosphorylase kinase deficiency 11.0
38 congenital cataracts, facial dysmorphism, and neuropathy 10.9
39 muscular dystrophy, limb-girdle, autosomal recessive 4 10.9
40 muscular dystrophy-dystroglycanopathy , type c, 5 10.9
41 dysferlinopathy 10.9
42 erythrocyte lactate transporter defect 10.9
43 glycogen storage disease ixd 10.9
44 brody disease 10.9
45 rhabdomyolysis-myalgia syndrome 10.9
46 tango2-related metabolic encephalopathy and arrhythmias 10.9
47 lactate dehydrogenase deficiency 10.9
48 mitochondrial dna-related mitochondrial myopathy 10.9
49 glycogen storage disease due to lactate dehydrogenase deficiency 10.9
50 exercise-induced malignant hyperthermia 10.9

Graphical network of the top 20 diseases related to Myoglobinuria:



Diseases related to Myoglobinuria

Symptoms & Phenotypes for Myoglobinuria

GenomeRNAi Phenotypes related to Myoglobinuria according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability after gemcitabine stimulation GR00107-A-2 8.8 PFKM PHKA1 PIK3C2A

MGI Mouse Phenotypes related to Myoglobinuria:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.56 ACADVL AMPD1 LPIN1 MB MT-CO1 PFKM
2 homeostasis/metabolism MP:0005376 9.5 ACADVL AMPD1 AMPD3 CPT2 HADH HP

Drugs & Therapeutics for Myoglobinuria

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Incidence of Rhabdomyolysis Among Pediatric and Adolescent Patients Admitted for Jimsonweed (Datura Stramonium) Ingestions Completed NCT00592657
2 Effect of Supplementation With Alpha-amino Acid Derivatives on the Level of Systemic Inflammatory Response and Post-workout Kidney Damage in Long Distance Runners Not yet recruiting NCT05510440

Search NIH Clinical Center for Myoglobinuria

Cochrane evidence based reviews: myoglobinuria

Genetic Tests for Myoglobinuria

Anatomical Context for Myoglobinuria

Organs/tissues related to Myoglobinuria:

MalaCards : Kidney, Skeletal Muscle, Spinal Cord, Liver, Bone Marrow, Heart, Brain

Publications for Myoglobinuria

Articles related to Myoglobinuria:

(show top 50) (show all 1489)
# Title Authors PMID Year
1
Myalgic Becker Muscular Dystrophy Due to an Exon 15 Point Mutation: Case Series and Literature Review. 62
36409343 2022
2
Severe rhabdomyolysis secondary to COVID-19 mRNA vaccine in a teenager. 62
36409362 2022
3
Toxic reaction of a 3-year-old boy due to Hornet multiple stings in Kerman-Iran province: A case report. 62
36403779 2022
4
Protective Effect of D-Panthenol in Rhabdomyolysis-Induced Acute Kidney Injury. 62
36293129 2022
5
A case of sub-acute compartment syndrome of bilateral pectoralis major, deltoid and triceps muscles. 62
36199505 2022
6
Benign acute childhood myositis: A 5-year retrospective study. 62
36109287 2022
7
Atorvastatin as a Rare Primary Cause of Drug-Induced Angioedema: A Case Report. 62
36225516 2022
8
Targeting Telomerase Enhances Cytotoxicity of Salinomycin in Cancer Cells. 62
36061682 2022
9
Acute kidney injury associated with rhabdomyolysis in a patient with COVID-19. 62
33704346 2022
10
Rhabdomyolysis and myoglobinuria following single induction dose of propofol in a dog. 62
35870123 2022
11
Rhabdomyolysis and Acute Kidney Injury Associated with Salmonella Infection: A Report of 2 Cases. 62
35672938 2022
12
Novel mutations in the HADHB gene causing a mild phenotype of mitochondrial trifunctional protein (MTP) deficiency. 62
35433169 2022
13
Approach to the diagnosis of metabolic myopathies. 62
35562160 2022
14
Discolored Urine in Horses and Foals. 62
35282957 2022
15
Proteomic analysis reveals rattlesnake venom modulation of proteins associated with cardiac tissue damage in mouse hearts. 62
35182786 2022
16
No effect of triheptanoin in patients with phosphofructokinase deficiency. 62
35241345 2022
17
Fatal rhabdomyolysis and disseminated intravascular coagulation after total knee arthroplasty under spinal anesthesia: A case report. 62
35211569 2022
18
Expanded dengue syndrome presented with rhabdomyolysis, compartment syndrome, and acute kidney injury: A case report. 62
35363190 2022
19
Pervitin Intoxication with Two-peak Massive Myoglobinemia, Acute Kidney Injury and Marked Procalcitonin Increase Not Associated with Sepsis. 62
36416465 2022
20
[Biochemical analysis of an uncommon monoclonal peak on urine protein electrophoresis: a case report]. 62
35317477 2022
21
Acute renal failure with severe loin pain and patchy renal ischemia after anaerobic exercise caused by rapid resumption after prolonged detraining. 62
35223044 2022
22
COVID-19 causing rhabdomyolysis requiring hemodialysis in a young adult. 62
35754607 2022
23
Psychosis-Induced Exertional Rhabdomyolysis without Acute Kidney Injury or Myoglobinuria. 62
34975144 2022
24
Feasibility and Safety of Whole-Body Electromyostimulation in Frail Older People-A Pilot Trial. 62
35812334 2022
25
South American snake venoms with abundant neurotoxic components. Composition and toxicological properties. A literature review. 62
34481791 2021
26
Diagnostic delay in patients with FKRP-related muscular dystrophy. 62
34857438 2021
27
Forced running-induced rhabdomyolysis in the Sprague-Dawley rat: towards a rodent model of capture myopathy. 62
34570329 2021
28
Repeatedly in Rhabdomyolysis. 62
32205805 2021
29
Acute nontraumatic rhabdomyolysis in a Greyhound after albuterol toxicosis. 62
34450682 2021
30
A Rare Case of Delayed Onset Multi-Drug Interaction Resulting in Rhabdomyolysis in a 66-Year-Old Male. 62
34987920 2021
31
A Rare Case of Adenosine Deaminase tRNA-Specific 3 Mutation, Adrenal Insufficiency, and Rhabdomyolysis. 62
34963848 2021
32
Acute kidney injury in pediatric non-traumatic rhabdomyolysis. 62
33851263 2021
33
Energy metabolism during exercise in patients with β-enolase deficiency (GSDXIII). 62
34485019 2021
34
Quality of Death in Fighting Bulls during Bullfights: Neurobiology and Physiological Responses. 62
34679841 2021
35
Acute Kidney Injury Among Children Admitted With Viral Rhabdomyolysis. 62
34301717 2021
36
Renal disorders in rheumatologic diseases: the spectrum is changing (Part 1: connective tissue diseases). 62
32529559 2021
37
The phenotypic and genotypic features of a Scottish cohort with McArdle disease. 62
34215481 2021
38
Risk factors and future directions for preventing and diagnosing exertional rhabdomyolysis. 62
34193371 2021
39
[MCARDLE'S DISEASE AND PHYSICAL ACTIVITY - A MIXED BLESSING]. 62
34160155 2021
40
Hypokalaemic rhabdomyolysis as initial presentation of primary aldosteronism. 62
34131672 2021
41
Acute renal failure with severe loin pain and patchy renal ischemia after anaerobic exercise. 62
33059989 2021
42
Exercise Induced Myoglobinuria is Determined by Haptoglobin Polymorphism. 62
33978364 2021
43
A novel PHKA1 mutation associating myopathy and cognitive impairment: Expanding the spectrum of phosphorylase kinase b (PhK) deficiency. 62
33799212 2021
44
Rhabdomyolysis: Revisited. 62
34276082 2021
45
From quail to earthquakes and human conflict: a historical perspective of rhabdomyolysis. 62
33841854 2021
46
Malignant hyperthermia in a 16-day-old infant with congenital diaphragmatic hernia: a case report. 62
33625594 2021
47
An Unusual Case of Compartment Syndrome of the Upper Extremity Caused by an iPad. 62
33996317 2021
48
Recurrent rhabdomyolysis and exercise intolerance: A new phenotype of late-onset thymidine kinase 2 deficiency. 62
33457207 2021
49
Management and outcome of benign acute childhood myositis in pediatric emergency department. 62
33750449 2021
50
Influenza A (H3N2) infection followed by anti-signal recognition particle antibody-positive necrotizing myopathy: A case report. 62
33217572 2021

Variations for Myoglobinuria

Expression for Myoglobinuria

Search GEO for disease gene expression data for Myoglobinuria.

Pathways for Myoglobinuria

Pathways related to Myoglobinuria according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.03 PYGM PIK3C2A PHKA1 PGK1 PGAM2 PGAM1
2
Show member pathways
12.5 PFKM PGAM1 PGAM2 PGK1 PHKA1 PYGM
3 12.31 PGAM1 MB LPIN1 LDHA
4
Show member pathways
11.97 PGK1 PGAM2 PGAM1 PFKM
5
Show member pathways
11.88 PGK1 PGAM2 PGAM1 PFKM LDHA
6 11.6 PGK1 PFKM LDHA
7
Show member pathways
11.57 PGK1 PGAM2 PGAM1
8 11.17 PGK1 PGAM1 LDHA
9
Show member pathways
11.1 HADH CPT2 ACADVL
10 10.59 LDHA GPT
11 10.49 PGK1 PGAM1 LDHA GPT
12 10.36 PGK1 LDHA
13 10.01 PGAM2 PGAM1

GO Terms for Myoglobinuria

Cellular components related to Myoglobinuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 respiratory chain complex IV GO:0045277 8.92 MT-CO3 MT-CO1

Biological processes related to Myoglobinuria according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cellular respiration GO:0045333 9.85 MT-CYB MT-CO3 MT-CO1
2 glycogen catabolic process GO:0005980 9.78 PYGM PFKM
3 fatty acid metabolic process GO:0006631 9.76 LPIN1 HADH CPT2 ACADVL
4 AMP metabolic process GO:0046033 9.73 AMPD3 AMPD1
5 fatty acid catabolic process GO:0009062 9.67 LPIN1 ACADVL
6 IMP salvage GO:0032264 9.62 AMPD1 AMPD3
7 IMP biosynthetic process GO:0006188 9.56 AMPD3 AMPD1
8 respiratory electron transport chain GO:0022904 9.46 MT-CYB MT-CO3 MT-CO1
9 canonical glycolysis GO:0061621 9.43 PGK1 PGAM2 PFKM
10 purine ribonucleoside monophosphate biosynthetic process GO:0009168 9.4 AMPD3 AMPD1
11 glycolytic process GO:0006096 9.32 PGK1 PGAM2 PGAM1 PFKM LDHA

Molecular functions related to Myoglobinuria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphoglycerate mutase activity GO:0004619 9.62 PGAM2 PGAM1
2 bisphosphoglycerate mutase activity GO:0004082 9.56 PGAM2 PGAM1
3 AMP deaminase activity GO:0003876 9.46 AMPD3 AMPD1
4 deaminase activity GO:0019239 9.4 AMPD3 AMPD1
5 intramolecular transferase activity, phosphotransferases GO:0016868 9.37 PGAM2 PGAM1
6 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity GO:0046538 9.26 PGAM2 PGAM1
7 catalytic activity GO:0003824 9.1 PYGM PGAM2 PGAM1 PFKM LDHA GPT

Sources for Myoglobinuria

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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