MCID: MYP006
MIFTS: 56

Myopia

Categories: Eye diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Myopia

MalaCards integrated aliases for Myopia:

Name: Myopia 12 76 37 29 55 6 44 15 40 73
Short-Sightedness 12
Near-Sightedness 12
Near Vision 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11830
ICD10 33 H52.1
ICD9CM 35 367.1
MeSH 44 D009216
NCIt 50 C102533
SNOMED-CT 68 155133003 57190000
KEGG 37 H02041
UMLS 73 C0027092

Summaries for Myopia

Disease Ontology : 12 A refractive error characterized by the inability to see farther objects clearly.

MalaCards based summary : Myopia, also known as short-sightedness, is related to marshall syndrome and refractive error, and has symptoms including aniseikonia An important gene associated with Myopia is COL2A1 (Collagen Type II Alpha 1 Chain). The drugs Atropine and Tropicamide have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and liver.

Wikipedia : 76 Near-sightedness, also known as short-sightedness and myopia, is a condition of the eye where light... more...

Related Diseases for Myopia

Diseases in the Myopia family:

Myopia 2, Autosomal Dominant Myopia 18, Autosomal Recessive
Myopia 3, Autosomal Dominant Myopia 17, Autosomal Dominant
Myopia 5, Autosomal Dominant Myopia 6
Myopia 7 Myopia 8
Myopia 9 Myopia 10
Myopia 11, Autosomal Dominant Myopia 12, Autosomal Dominant
Myopia 14 Myopia 16, Autosomal Dominant
Myopia 15, Autosomal Dominant Myopia 19, Autosomal Dominant
Myopia 20, Autosomal Dominant Myopia 21, Autosomal Dominant
Myopia 22, Autosomal Dominant Myopia 23, Autosomal Recessive
Myopia 24, Autosomal Dominant Myopia 25, Autosomal Dominant

Diseases related to Myopia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 287)
# Related Disease Score Top Affiliating Genes
1 marshall syndrome 33.7 COL11A1 COL2A1
2 refractive error 33.4 LRPAP1 PRIMPOL SCO2 SLC39A5 ZNF644
3 rare isolated myopia 32.7 CHD7 COL2A1 FBN1 LRPAP1 P3H2 SCO2
4 kniest dysplasia 31.7 COL11A1 COL2A1
5 lens subluxation 31.1 FBN1 P3H2
6 strabismus 30.3 COL11A1 COL2A1 TYR
7 deafness and myopia 12.3
8 degenerative myopia 12.2
9 myopia 13, x-linked 12.2
10 myopia 6 12.1
11 epiphyseal dysplasia, multiple, with myopia and conductive deafness 12.1
12 myopia 21, autosomal dominant 12.1
13 polydactyly, postaxial, with progressive myopia 12.1
14 myopia 2, autosomal dominant 12.1
15 myopia 23, autosomal recessive 12.1
16 myopia, high, with cataract and vitreoretinal degeneration 12.1
17 myopia 22, autosomal dominant 12.1
18 myopia 24, autosomal dominant 12.1
19 myopia 17, autosomal dominant 12.1
20 myopia 26, x-linked, female-limited 12.1
21 myopia 18, autosomal recessive 12.1
22 myopia 5, autosomal dominant 12.1
23 myopia 11, autosomal dominant 12.1
24 myopia 12, autosomal dominant 12.1
25 myopia 16, autosomal dominant 12.1
26 myopia 15, autosomal dominant 12.1
27 myopia 19, autosomal dominant 12.1
28 myopia 25, autosomal dominant 12.1
29 myopia 7 12.0
30 myopia 8 12.0
31 myopia 9 12.0
32 myopia 10 12.0
33 myopia 14 12.0
34 myopia 20, autosomal dominant 12.0
35 joint laxity, short stature, and myopia 12.0
36 myopia 1, x-linked 12.0
37 myopia 3, autosomal dominant 12.0
38 aplasia cutis congenita, high myopia, and cone-rod dysfunction 11.9
39 night blindness, congenital stationary, type 1a 11.9
40 blepharoptosis, myopia, and ectopia lentis 11.8
41 sinus node disease and myopia 11.8
42 ophthalmoplegia, external, and myopia 11.8
43 spondyloepiphyseal dysplasia, myopia, and sensorineural deafness 11.8
44 dandy-walker malformation with mental retardation, macrocephaly, myopia, and brachytelephalangy 11.8
45 x-linked congenital stationary night blindness 11.7
46 epiphyseal dysplasia of femoral head, myopia, and deafness 11.7
47 spinocerebellar degeneration with macular corneal dystrophy, congenital cataracts, and myopia 11.7
48 camptodactyly, myopia, and fibrosis of the medial rectus muscle of eye 11.7
49 aplasia cutis myopia 11.7
50 optic atrophy opthalmoplegia ptosis deafness myopia 11.7

Graphical network of the top 20 diseases related to Myopia:



Diseases related to Myopia

Symptoms & Phenotypes for Myopia

UMLS symptoms related to Myopia:


aniseikonia

Drugs & Therapeutics for Myopia

Drugs for Myopia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 978)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Atropine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 5908-99-6, 51-55-8 174174
2
Tropicamide Approved, Investigational Phase 4,Phase 2,Not Applicable 1508-75-4 5593
3
Iodine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 7553-56-2 807
4
Ranibizumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 347396-82-1 459903
5
Ephedrine Approved Phase 4,Phase 3,Phase 2,Not Applicable 299-42-3 9294
6
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Not Applicable 90-82-4 7028
7
Desflurane Approved Phase 4,Not Applicable 57041-67-5 42113
8
Isoflurane Approved, Vet_approved Phase 4,Not Applicable 26675-46-7 3763
9
Sevoflurane Approved, Vet_approved Phase 4,Phase 2,Not Applicable 28523-86-6 5206
10 Beractant Approved Phase 4 108778-82-1
11 Poractant alfa Approved Phase 4,Phase 3 129069-19-8
12
Cefmetazole Approved, Investigational Phase 4 56796-20-4 42008
13
Celecoxib Approved, Investigational Phase 4,Not Applicable 169590-42-5 2662
14
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 51-43-4 5816
15
Ketorolac Approved Phase 4,Phase 2,Not Applicable 74103-06-3, 66635-83-4 3826
16
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 57-27-2 5288826
17
Oxycodone Approved, Illicit, Investigational Phase 4,Not Applicable 76-42-6 5284603
18
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 329-65-7 838
19
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Not Applicable 84057-95-4 71273 175805
20
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-84-3 187
21
Oxymetazoline Approved, Investigational Phase 4,Phase 2,Not Applicable 1491-59-4 4636
22
Phenylephrine Approved Phase 4,Phase 2,Not Applicable 59-42-7 6041
23
Pancrelipase Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 53608-75-6
24
Capsaicin Approved Phase 4,Phase 1,Phase 2 404-86-4 1548943
25
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 1,Not Applicable 59467-70-8 4192
26
Remifentanil Approved Phase 4,Phase 3,Phase 2,Not Applicable 132875-61-7 60815
27
Simvastatin Approved Phase 4,Phase 3 79902-63-9 54454
28
Dobutamine Approved Phase 4,Phase 1,Phase 2,Not Applicable 34368-04-2 36811
29
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-61-6, 62-31-7 681
30
Dipivefrin Approved Phase 4,Not Applicable 52365-63-6 3105
31
4-Aminopyridine Approved Phase 4,Phase 3 504-24-5 1727
32
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 216974-75-3
33
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 2180-92-9, 38396-39-3 2474
34
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 137-58-6 3676
35
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 2078-54-8 4943
36
Metronidazole Approved Phase 4,Phase 1,Phase 2,Not Applicable 443-48-1 4173
37
Docetaxel Approved, Investigational Phase 4,Phase 2 114977-28-5 148124
38
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Not Applicable 437-38-7 3345
39
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
40
Menthol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2216-51-5 16666
41
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
42
Heparin Approved, Investigational Phase 4,Phase 3,Not Applicable 9005-49-6 772 46507594
43
Ethanol Approved Phase 4,Phase 2,Phase 1,Not Applicable 64-17-5 702
44
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 23214-92-8 31703
45
Lamivudine Approved, Investigational Phase 4,Phase 2,Phase 3 134678-17-4 60825
46
Nevirapine Approved Phase 4,Phase 2,Phase 3 129618-40-2 4463
47
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
48
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Not Applicable 51-21-8 3385
49
Emtricitabine Approved, Investigational Phase 4,Phase 2,Phase 3 143491-57-0 60877
50
Treprostinil Approved, Investigational Phase 4,Phase 3 81846-19-7 54786 6918140

Interventional clinical trials:

(show top 50) (show all 3320)
# Name Status NCT ID Phase Drugs
1 Study of Myopia Prevention in Children With Low Concentration of Atropine Unknown status NCT00541177 Phase 4 atropine;tropicamide
2 Echothiophate Iodide for the Prevention of Progression of Myopia Unknown status NCT02544529 Phase 4 Echothiophate Iodide 0.03% Ophthalmic Solution;Carboxymethylcellulose Sodium (0.5%)
3 Ranibizumab for Myopic Neovascularization Unknown status NCT01246089 Phase 4 ranibizumab injection
4 Aflibercept Intravitreal Injection for Myopic Choroidal Neovascularization Unknown status NCT02033018 Phase 4 Aflibercept Injection
5 A Prospective Safety and Effectiveness Study of the 500 Hz Technolas Perfect Vision Excimer Laser in Asian Eyes Using LASIK Unknown status NCT01977807 Phase 4
6 Multi Laser Platform Comparison Study for LASIK Unknown status NCT00770094 Phase 4
7 A Prospective Safety and Effectiveness Study of the 500 Hz Technolas Perfect Vision Excimer Laser Using LASIK Unknown status NCT02071576 Phase 4
8 A Prospective Safety and Effectiveness Study of a New High Repetition Rate Excimer Laser Using LASIK for the Correction of Ammetropia and Presbyopia Unknown status NCT02112968 Phase 4
9 Clinical Investigation of the Bi Flex M Multifocal IOL Unknown status NCT02338882 Phase 4
10 The Effect of Mydriatic Eye Drops on Cerebral and Mesenteric Oxygenation in Preterm Infants Unknown status NCT01305720 Phase 4
11 Comparison of Volatile Anesthetics on Cerebral Oxygenation During Controlled Hypotension Unknown status NCT02834845 Phase 4 Sevoflurane;Desflurane
12 In Vitro and In Vivo Comparison Between Intravascular Ultrasound (IVUS) Systems Unknown status NCT02154295 Phase 4
13 Adverse Plaque Characteristics in CCTA and TVC Imaging Unknown status NCT02350959 Phase 4 Atorvastatin;Atorvastatin
14 Brain Oxygenation and Function of Preterm Newborns During Administration of Two Different Surfactant Preparations Unknown status NCT01941524 Phase 4 Poractant alfa instillation;Beractant instillation
15 VeinViewer Assisted Intravenous Catheter Placement in the Pediatric Emergency Department Unknown status NCT00468065 Phase 4
16 The Effect of Periarticular Multi-Drug Regimen on Pain After Partial Hip Replacement Unknown status NCT01112436 Phase 4 periarticular injection of multidrug regimen;none of medication preoperatively and intraoperatively
17 Preoperative Anxiety and Postoperative Pain in Children Unknown status NCT00643032 Phase 4
18 Evaluation of Visual Outcomes of Monovision Patients Bilaterally Implanted With Nanoflex Intraocular Lenses Unknown status NCT01279122 Phase 4
19 Botulinum Toxin A for Treatment of Catocholamine Induced Finger Necrosis Unknown status NCT01500668 Phase 4 Botox;Placebo
20 Compared Efficacy and Tolerance of Two Vasopressors Used to Treat Preoperative Hypotension During Carotid Surgery Unknown status NCT01794273 Phase 4 ephedrine and phenylephrine
21 Effect of Deep Brain Stimulation on Gait of Patients With Parkinson's Disease Depending on Electrode Location in Subthalamic Area Unknown status NCT01782638 Phase 4
22 Treatment of Low Blood Sugar With Glucagon Among Patients With Type 1 Diabetes Unknown status NCT02232971 Phase 4 Glucagon
23 The Effect of High-dose Remifentanil on Established Capsaicin-induced Hyperalgesia in Human Volunteers Unknown status NCT00886106 Phase 4 Remifentanil;Midazolam
24 The Effect of High-dose Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers (HighDose RemiSun) Unknown status NCT01015482 Phase 4 Remifentanil;Midazolam
25 The Effect of Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers Unknown status NCT00811837 Phase 4 Midazolam;Remifentanil
26 The Effect of Remifentanil on Established Capsaicin-Induced Hyperalgesia in Human Volunteers Unknown status NCT00789386 Phase 4 Remifentanil;Midazolam
27 Crossover of Higher Dose Statins in Patients With Low High-density Lipoproteins Cholesterol (HDLc) Unknown status NCT00736463 Phase 4 Simvastatin;Atorvastatin 80 mg
28 Quadripolar Leads for the Management of Heart Failure Patients in the Middle East Unknown status NCT02195843 Phase 4
29 Evaluation of Immunogenicity Levels in Women With HPV Vaccine in Mexico Unknown status NCT01717118 Phase 4
30 Dopamine Versus Dobutamine for Treatment of Arterial Hypotension in Term and Preterm Neonates Unknown status NCT01427686 Phase 4 Dobutamine;Dopamine
31 Cosmetic Dermatology Study Unknown status NCT02200471 Phase 4
32 AMO's Tecnis™ Multifocal Intraocular Lenses (Tecnis MF), Alcon's ReStor Multifocal IOL Unknown status NCT01278420 Phase 4
33 Short and Long Term Multiple Outcomes in Persons With Multiple Sclerosis Treated by Fampridine. Unknown status NCT02849782 Phase 4 Fampridine
34 Effect of Orthokeratology Versus Spectacles on Myopia Progression in Chinese Children: A Crossover Trial Completed NCT02186184 Phase 4
35 Visual Outcomes and Contrast Sensitivity After Myopic LASIK Completed NCT01746589 Phase 4
36 Evaluation of the Prophylactic Use of Mitomycin C 0.02% to Inhibit Haze Formation After Photorefractive Keratectomy for High Myopia: 15 x 30 Seconds Completed NCT00564213 Phase 4 PRK and a single intraoperative topical application of mitomycin C 0.02% for 15 seconds
37 A Comparison of PRK and LASIK for Correction of Myopia Completed NCT00404105 Phase 4
38 An Evaluation of Outcomes Following Wavefront Optimized or Wavefront Guided Lasik Procedure in Low to Moderate Myopic Patients Completed NCT01173198 Phase 4
39 Bevacizumab Intravitreal for Myopic Choroidal Neovascularization Completed NCT00797992 Phase 4 Injection
40 SD-OCT-guided Intravitreal Ranibizumab Treatment in Choroidal Neovascularization Due to Myopia Completed NCT03409250 Phase 4 Ranibizumab, Lucentis
41 Presbyopic Supracor Treatment for Near Myopic/Hyperopic Pseudophakic Eyes Completed NCT01387360 Phase 4
42 Three Intraocular Lenses Designed to Improve Distance, Intermediate and Near Vision Following Lens Extraction Completed NCT01225952 Phase 4
43 Evaluation of the Post-LASIK Flap Thickness of the FS200 Femtosecond Laser Flap Completed NCT01693939 Phase 4
44 Contralateral Comparison of Three Excimer Laser Systems in Performing LASIK Completed NCT00821236 Phase 4
45 Clinical Study of Approved Contact Lenses Completed NCT03351101 Phase 4
46 Overall Performance of a 1-day Silicone Hydrogel Lens When Habitual Soft Lens Wearers Are Refit Completed NCT02588573 Phase 4
47 BIOCLEAN MPS (Multi-Purpose Solution) VII in Combination With Biofinity Lens: A Two Week Crossover Study Completed NCT02537730 Phase 4
48 Clinical Evaluation of Daily Disposable Contact Lenses Completed NCT02097030 Phase 4
49 Daily Disposable Comparison Study Completed NCT02094677 Phase 4
50 Multi-center Clinical Evaluation of PC 1-Day vs 1-Day Acuvue Moist Completed NCT02024698 Phase 4

Search NIH Clinical Center for Myopia

Cochrane evidence based reviews: myopia

Genetic Tests for Myopia

Genetic tests related to Myopia:

# Genetic test Affiliating Genes
1 Myopia 29

Anatomical Context for Myopia

MalaCards organs/tissues related to Myopia:

41
Brain, Eye, Liver, Heart, Prostate, Testes, Lymph Node

Publications for Myopia

Articles related to Myopia:

(show top 50) (show all 1174)
# Title Authors Year
1
Additive effects of orthokeratology and atropine 0.01% ophthalmic solution in slowing axial elongation in children with myopia: first year results. ( 29974278 )
2018
2
Impact of varying the definition of myopia on estimates of prevalence and associations with risk factors: time for an approach that serves research, practice and policy. ( 29437571 )
2018
3
Chromatic and achromatic visual fields in relation to choroidal thickness in patients with high myopia: A pilot study. ( 29396209 )
2018
4
Design and Baseline Characteristics of the HELP Study: An Extended and Long-Term Observation of Pathological Myopia in Caucasians. ( 29909408 )
2018
5
Inverted internal limiting membrane insertion versus standard internal limiting membrane peeling for macular hole retinal detachment in high myopia: one-year study. ( 29911271 )
2018
6
Myopia Control: Current Thoughts and Future Research. ( 29923880 )
2018
7
Association of the<i>PAX6</i>gene with extreme myopia rather than lower grade myopias. ( 29436400 )
2018
8
Investigating the long-term impact of a childhood sun-exposure intervention, with a focus on eye health: protocol for the Kidskin-Young Adult Myopia Study. ( 29391375 )
2018
9
A highly efficient murine model of experimental myopia. ( 29391484 )
2018
10
Early quantitative profiling of differential retinal protein expression in lens-induced myopia in guinea pig using fluorescence difference two-dimensional gel electrophoresis. ( 29436656 )
2018
11
Autosomal-dominant myopia associated to a novel P4HA2 missense variant and defective collagen hydroxylation. ( 29364500 )
2018
12
The measurement of time spent outdoors in child myopia research: a systematic review. ( 29977821 )
2018
13
FULL-THICKNESS MACULAR HOLE WITH MACULAR INTRACHOROIDAL CAVITATION IN A PATIENT WITH PATHOLOGIC MYOPIA. ( 29443802 )
2018
14
Metacognitive Myopia in Hidden-Profile Tasks: The Failure to Control for Repetition Biases. ( 29922208 )
2018
15
Lamellar macular holes in the eyes with pathological myopia. ( 29725825 )
2018
16
Association between Optic Nerve Head Deformation and Retinal Microvasculature in High Myopia. ( 29421295 )
2018
17
Myopia prevalence in Canadian school children: a pilot study. ( 29391573 )
2018
18
Allergic Conjunctivitis-induced Retinal Inflammation Promotes Myopia Progression. ( 29398596 )
2018
19
Multiple Free Internal Limiting Membrane Flap Insertion in the Treatment of Macular Hole-Associated Retinal Detachment in High Myopia. ( 29874671 )
2018
20
Education and myopia: assessing the direction of causality by mendelian randomisation. ( 29973342 )
2018
21
Breastfeeding and myopia: A cross-sectional study of children aged 6-12 years in Tianjin, China. ( 29968726 )
2018
22
Axial Elongation in Myopic Children and its Association With Myopia Progression in the Correction of Myopia Evaluation Trial. ( 29923883 )
2018
23
Myopia: its historical contexts. ( 29437569 )
2018
24
Outcomes of LASIK for Myopia or Myopic Astigmatism Correction with the FS200 Femtosecond Laser and EX500 Excimer Laser Platform. ( 29872485 )
2018
25
Incidence of and Factors Associated With Myopia and High Myopia in Chinese Children, Based on Refraction Without Cycloplegia. ( 29978185 )
2018
26
Clinical Research on the Efficacy of Modified Surgery for Esotropia Fixus With High Myopia. ( 29709045 )
2018
27
Pathway analysis identifies altered mitochondrial metabolism, neurotransmission, structural pathways and complement cascade in retina/RPE/ choroid in chick model of form-deprivation myopia. ( 29967729 )
2018
28
Detection of Bruch's Membrane Opening in Healthy Individuals and Glaucoma Patients with and without High Myopia. ( 29934269 )
2018
29
Acquired myopia in Vogt-Koyanagi-Harada disease. ( 29397539 )
2018
30
A novel mutation in SLITRK6 causes deafness and myopia in a Moroccan family. ( 29551497 )
2018
31
Low-Dose Atropine for Myopia Control: Considering All the Data. ( 29423500 )
2018
32
Myopia, the challenge of Ophthalmology and its worldwide &amp;quot;explosive epidemic&amp;quot;. ( 29929762 )
2018
33
Narrow-band, long-wavelength lighting promotes hyperopia and retards vision-induced myopia in infant rhesus monkeys. ( 29981345 )
2018
34
The Role of Orthokeratology in Myopia Control: A Review. ( 29923882 )
2018
35
Choroidal Thickness in Chinese Children Aged 8 to 11 Years with Mild and Moderate Myopia. ( 29955394 )
2018
36
Predictability of the Achieved Lenticule Thickness in Small Incision Lenticule Extraction for Myopia Correction. ( 29944495 )
2018
37
The Associations between Near Visual Activity and Incident Myopia in Children: A Nationwide 4-Year Follow-up Study. ( 29934268 )
2018
38
The increasing prevalence of myopia and high myopia among high school students in Fenghua city, eastern China: a 15-year population-based survey. ( 29970057 )
2018
39
Optical 'dampening' of the refractive error to axial length ratio: implications for outcome measures in myopia control studies. ( 29691929 )
2018
40
Treatment of high myopia/myopic astigmatism with a combination of WaveLight Contoura with LYRA protocol and wavefront-optimized treatment. ( 29785083 )
2018
41
Low-Dose Atropine for Myopia Control-Reply. ( 29423510 )
2018
42
POSTERIOR PRECORTICAL VITREOUS POCKETS IN HIGH MYOPIA OBSERVED BY ENHANCED VITREOUS IMAGING OF SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY. ( 29443795 )
2018
43
Food and Drug Administration, American Academy of Ophthalmology, American Academy of Optometry, American Association for Pediatric Ophthalmology and Strabismus, American Optometric Association, American Society of Cataract and Refractive Surgery, and Contact Lens Association of Ophthalmologists Co-Sponsored Workshop: Controlling the Progression of Myopia: Contact Lenses and Future Medical Devices. ( 29923881 )
2018
44
Role of short-wavelength filtering lenses in delaying myopia progression and amelioration of asthenopia in juveniles. ( 28861353 )
2017
45
Novel evidence for complement system activation in chick myopia and hyperopia models: a meta-analysis of transcriptome datasets. ( 28852117 )
2017
46
Interventions to control myopia progression in children: protocol for an overview of systematic reviews and meta-analyses. ( 28893307 )
2017
47
Myopia as a risk factor for subsequent retinal tears in the course of a symptomatic posterior vitreous detachment. ( 29191240 )
2017
48
Drug-induced Myopia and Bilateral Angle Closure Secondary to Zolmitriptan. ( 28858962 )
2017
49
Methodology of the ZOC-BHVI High Myopia Cohort Study: The Onset and Progression of Myopic Pathologies and Associated Risk Factors in Highly Myopic Chinese. ( 28891727 )
2017
50
Association between parents' attitudes and behaviors toward children's visual care and myopia risk in school-aged children. ( 29384911 )
2017

Variations for Myopia

ClinVar genetic disease variations for Myopia:

6
(show all 48)
# Gene Variation Type Significance SNP ID Assembly Location
1 TYR NM_000372.4(TYR): c.1A> G (p.Met1Val) single nucleotide variant Pathogenic rs28940881 GRCh37 Chromosome 11, 88911122: 88911122
2 TYR NM_000372.4(TYR): c.1A> G (p.Met1Val) single nucleotide variant Pathogenic rs28940881 GRCh38 Chromosome 11, 89177954: 89177954
3 COL2A1 NM_033150.2(COL2A1): c.2503C> T (p.Arg835Cys) single nucleotide variant Pathogenic rs121912882 GRCh37 Chromosome 12, 48373317: 48373317
4 COL2A1 NM_033150.2(COL2A1): c.2503C> T (p.Arg835Cys) single nucleotide variant Pathogenic rs121912882 GRCh38 Chromosome 12, 47979534: 47979534
5 TYR NM_000372.4(TYR): c.1037-7T> A single nucleotide variant Pathogenic/Likely pathogenic rs61754381 GRCh37 Chromosome 11, 88960984: 88960984
6 TYR NM_000372.4(TYR): c.1037-7T> A single nucleotide variant Pathogenic/Likely pathogenic rs61754381 GRCh38 Chromosome 11, 89227816: 89227816
7 SLC39A13 NM_152264.4(SLC39A13): c.398C> T (p.Thr133Met) single nucleotide variant Conflicting interpretations of pathogenicity rs140574574 GRCh37 Chromosome 11, 47433573: 47433573
8 SLC39A13 NM_152264.4(SLC39A13): c.398C> T (p.Thr133Met) single nucleotide variant Conflicting interpretations of pathogenicity rs140574574 GRCh38 Chromosome 11, 47412022: 47412022
9 COL4A4 NM_000092.4(COL4A4): c.2320G> C (p.Gly774Arg) single nucleotide variant Likely pathogenic rs569681869 GRCh37 Chromosome 2, 227924184: 227924184
10 COL4A4 NM_000092.4(COL4A4): c.2320G> C (p.Gly774Arg) single nucleotide variant Likely pathogenic rs569681869 GRCh38 Chromosome 2, 227059468: 227059468
11 RSRC2 NM_023012.5(RSRC2): c.425G> A (p.Arg142Gln) single nucleotide variant Likely pathogenic rs752134549 GRCh37 Chromosome 12, 123001951: 123001951
12 RSRC2 NM_023012.5(RSRC2): c.425G> A (p.Arg142Gln) single nucleotide variant Likely pathogenic rs752134549 GRCh38 Chromosome 12, 122517404: 122517404
13 46;X;t(X;9)(p22.2;p13)dn Translocation Uncertain significance
14 46;XY;t(2;14)(p23;q13)dn Translocation Uncertain significance
15 46;XY;t(5;15)(q11.2;q24) Translocation Pathogenic
16 ZNF469 NM_001127464.2(ZNF469): c.470G> A (p.Gly157Glu) single nucleotide variant Uncertain significance rs781096189 GRCh38 Chromosome 16, 88427940: 88427940
17 ZNF469 NM_001127464.2(ZNF469): c.470G> A (p.Gly157Glu) single nucleotide variant Uncertain significance rs781096189 GRCh37 Chromosome 16, 88494348: 88494348
18 MT-TL1 NC_012920.1: m.3275C> T single nucleotide variant Uncertain significance rs1057516057 GRCh37 Chromosome MT, 3275: 3275
19 MT-TL1 NC_012920.1: m.3275C> T single nucleotide variant Uncertain significance rs1057516057 GRCh38 Chromosome MT, 3275: 3275
20 POGZ NM_015100.3(POGZ): c.402_409dupTGCCAATC (p.His137Leufs) duplication Likely pathogenic rs1057518799 GRCh38 Chromosome 1, 151430716: 151430723
21 POGZ NM_015100.3(POGZ): c.402_409dupTGCCAATC (p.His137Leufs) duplication Likely pathogenic rs1057518799 GRCh37 Chromosome 1, 151403192: 151403199
22 CHD7 NM_017780.3(CHD7): c.6892C> T (p.Gln2298Ter) single nucleotide variant Pathogenic rs1057518891 GRCh37 Chromosome 8, 61767038: 61767038
23 CHD7 NM_017780.3(CHD7): c.6892C> T (p.Gln2298Ter) single nucleotide variant Pathogenic rs1057518891 GRCh38 Chromosome 8, 60854479: 60854479
24 FBN1 NM_000138.4(FBN1): c.6800A> T (p.Asn2267Ile) single nucleotide variant Pathogenic rs1057518812 GRCh38 Chromosome 15, 48430742: 48430742
25 FBN1 NM_000138.4(FBN1): c.6800A> T (p.Asn2267Ile) single nucleotide variant Pathogenic rs1057518812 GRCh37 Chromosome 15, 48722939: 48722939
26 FBN1 NM_000138.4(FBN1): c.1481G> T (p.Cys494Phe) single nucleotide variant Likely pathogenic rs1057518881 GRCh37 Chromosome 15, 48805853: 48805853
27 FBN1 NM_000138.4(FBN1): c.1481G> T (p.Cys494Phe) single nucleotide variant Likely pathogenic rs1057518881 GRCh38 Chromosome 15, 48513656: 48513656
28 FBN1 NM_000138.4(FBN1): c.840_843delTGAA (p.Asn280Lysfs) deletion Pathogenic rs1057518909 GRCh37 Chromosome 15, 48826296: 48826299
29 FBN1 NM_000138.4(FBN1): c.840_843delTGAA (p.Asn280Lysfs) deletion Pathogenic rs1057518909 GRCh38 Chromosome 15, 48534099: 48534102
30 MYH11 NM_001040113.1(MYH11): c.4381G> C (p.Asp1461His) single nucleotide variant Likely pathogenic rs1057518938 GRCh38 Chromosome 16, 15724166: 15724166
31 MYH11 NM_001040113.1(MYH11): c.4381G> C (p.Asp1461His) single nucleotide variant Likely pathogenic rs1057518938 GRCh37 Chromosome 16, 15818023: 15818023
32 EP300 NM_001429.3(EP300): c.2053+4A> T single nucleotide variant Uncertain significance rs1057518889 GRCh37 Chromosome 22, 41537230: 41537230
33 EP300 NM_001429.3(EP300): c.2053+4A> T single nucleotide variant Uncertain significance rs1057518889 GRCh38 Chromosome 22, 41141226: 41141226
34 AFF2 NM_002025.3(AFF2): c.3209A> G (p.His1070Arg) single nucleotide variant Uncertain significance rs1057518785 GRCh37 Chromosome X, 148049164: 148049164
35 AFF2 NM_002025.3(AFF2): c.3209A> G (p.His1070Arg) single nucleotide variant Uncertain significance rs1057518785 GRCh38 Chromosome X, 148967634: 148967634
36 CACNA1F NM_005183.3(CACNA1F): c.694A> T (p.Lys232Ter) single nucleotide variant Likely pathogenic rs1057518829 GRCh37 Chromosome X, 49086805: 49086805
37 CACNA1F NM_005183.3(CACNA1F): c.694A> T (p.Lys232Ter) single nucleotide variant Likely pathogenic rs1057518829 GRCh38 Chromosome X, 49230343: 49230343
38 COL11A1 NM_080629.2(COL11A1): c.4084_4101delTCTGGTGAGGCTGGCCCA (p.Ser1362_Pro1367del) deletion Likely pathogenic GRCh37 Chromosome 1, 103377736: 103377753
39 COL11A1 NM_080629.2(COL11A1): c.4084_4101delTCTGGTGAGGCTGGCCCA (p.Ser1362_Pro1367del) deletion Likely pathogenic GRCh38 Chromosome 1, 102912180: 102912197
40 COL4A4 NM_000092.4(COL4A4): c.4394G> A (p.Gly1465Asp) single nucleotide variant Likely pathogenic rs533297350 GRCh38 Chromosome 2, 227010441: 227010441
41 COL4A4 NM_000092.4(COL4A4): c.4394G> A (p.Gly1465Asp) single nucleotide variant Likely pathogenic rs533297350 GRCh37 Chromosome 2, 227875157: 227875157
42 TNC NM_002160.3(TNC): c.890A> G (p.Asn297Ser) single nucleotide variant Uncertain significance GRCh37 Chromosome 9, 117849120: 117849120
43 TNC NM_002160.3(TNC): c.890A> G (p.Asn297Ser) single nucleotide variant Uncertain significance GRCh38 Chromosome 9, 115086841: 115086841
44 ZNF469 NM_001127464.2(ZNF469): c.2569A> G (p.Asn857Asp) single nucleotide variant Uncertain significance GRCh37 Chromosome 16, 88496447: 88496447
45 ZNF469 NM_001127464.2(ZNF469): c.2569A> G (p.Asn857Asp) single nucleotide variant Uncertain significance GRCh38 Chromosome 16, 88430039: 88430039
46 ZNF469 NM_001127464.2(ZNF469): c.9448G> A (p.Gly3150Ser) single nucleotide variant Uncertain significance rs887755283 GRCh37 Chromosome 16, 88503410: 88503410
47 ZNF469 NM_001127464.2(ZNF469): c.9448G> A (p.Gly3150Ser) single nucleotide variant Uncertain significance rs887755283 GRCh38 Chromosome 16, 88437002: 88437002
48 subset of 22 genes:FLCN; RAI1 GRCh37/hg19 17p11.2(chr17: 16936603-18184130) copy number loss Pathogenic GRCh37 Chromosome 17, 16936603: 18184130

Expression for Myopia

Search GEO for disease gene expression data for Myopia.

Pathways for Myopia

GO Terms for Myopia

Cellular components related to Myopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.26 COL11A1 COL2A1 FBN1 P3H2
2 basement membrane GO:0005604 8.8 COL2A1 FBN1 P3H2

Biological processes related to Myopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.63 CHD7 COL2A1 FBN1
2 camera-type eye development GO:0043010 9.5 CHD7 FBN1 SLITRK6
3 sensory perception of sound GO:0007605 9.46 CHD7 COL11A1 COL2A1 SLITRK6
4 innervation GO:0060384 9.43 CHD7 SLITRK6
5 heart morphogenesis GO:0003007 9.43 CHD7 COL11A1 COL2A1
6 cartilage condensation GO:0001502 9.4 COL11A1 COL2A1
7 proteoglycan metabolic process GO:0006029 9.37 COL11A1 COL2A1
8 visual perception GO:0007601 9.35 COL11A1 COL2A1 NYX SLITRK6 TYR
9 inner ear morphogenesis GO:0042472 8.92 CHD7 COL11A1 COL2A1 SLITRK6

Molecular functions related to Myopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 8.8 COL11A1 COL2A1 FBN1

Sources for Myopia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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30 HGMD
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69 SNOMED-CT via HPO
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74 UMLS via Orphanet
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