MYP15
MCID: MYP146
MIFTS: 21

Myopia 15, Autosomal Dominant (MYP15)

Categories: Eye diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Myopia 15, Autosomal Dominant

MalaCards integrated aliases for Myopia 15, Autosomal Dominant:

Name: Myopia 15, Autosomal Dominant 57
Myopia 15 57 13 70
Myp15 57

Characteristics:

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
autosomal dominant

Miscellaneous:
reported in a large hutterite family


HPO:

31
myopia 15, autosomal dominant:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM® 57 612717
OMIM Phenotypic Series 57 PS160700
MedGen 41 C2675180
SNOMED-CT via HPO 68 263681008 57190000
UMLS 70 C2675180

Summaries for Myopia 15, Autosomal Dominant

OMIM® : 57 Myopia, or nearsightedness, is a refractive error of the eye. Light rays from a distant object are focused in front of the retina and those from a near object are focused in the retina; therefore distant objects are blurry and near objects are clear (summary by Kaiser et al., 2004). For a discussion of genetic heterogeneity of susceptibility to myopia, see 160700. (612717) (Updated 20-May-2021)

MalaCards based summary : Myopia 15, Autosomal Dominant, also known as myopia 15, is related to myopia and myopia 10. An important gene associated with Myopia 15, Autosomal Dominant is MYP15 (Myopia 15). The drugs Antibiotics, Antitubercular and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include eye and retina, and related phenotype is myopia.

Related Diseases for Myopia 15, Autosomal Dominant

Symptoms & Phenotypes for Myopia 15, Autosomal Dominant

Human phenotypes related to Myopia 15, Autosomal Dominant:

31
# Description HPO Frequency HPO Source Accession
1 myopia 31 HP:0000545

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Head And Neck Eyes:
myopia, high-grade (average refractive error -7.04 diopters)

Clinical features from OMIM®:

612717 (Updated 20-May-2021)

Drugs & Therapeutics for Myopia 15, Autosomal Dominant

Drugs for Myopia 15, Autosomal Dominant (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibiotics, Antitubercular Phase 4
2 Anti-Bacterial Agents Phase 4
3 Mitomycins Phase 4
4 Alkylating Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of the Prophylactic Use of Mitomycin C 0.02% to Inhibit Haze Formation After Photorefractive Keratectomy for High Myopia: 15 x 30 Seconds Completed NCT00564213 Phase 4 PRK and a single intraoperative topical application of mitomycin C 0.02% for 15 seconds

Search NIH Clinical Center for Myopia 15, Autosomal Dominant

Genetic Tests for Myopia 15, Autosomal Dominant

Anatomical Context for Myopia 15, Autosomal Dominant

MalaCards organs/tissues related to Myopia 15, Autosomal Dominant:

40
Eye, Retina

Publications for Myopia 15, Autosomal Dominant

Articles related to Myopia 15, Autosomal Dominant:

(show all 13)
# Title Authors PMID Year
1
Genetic linkage study of high-grade myopia in a Hutterite population from South Dakota. 57
17327828 2007
2
Time spent outdoors in childhood is associated with reduced risk of myopia as an adult. 61
33737652 2021
3
Influence of vision on masticatory muscles function: surface electromyographic evaluation. 61
25002919 2014
4
Subfoveal choroidal thickness: the Beijing Eye Study. 61
23009895 2013
5
Severe hyperopic shift and irregular astigmatism after radial keratotomy. 61
19812501 2009
6
[Analysis of clinical features of choroidal neovascularization]. 61
19175155 2008
7
Inhibitory effects of apomorphine and atropine and their combination on myopia in chicks. 61
15127933 2004
8
Lincoff temporary balloon buckle in retinal detachment surgery. 61
11820310 2001
9
[Possibilities of special correction in restoration of reading capacity in poorly sighted patients]. 61
11765464 2001
10
Refractive errors in an older population: the Blue Mountains Eye Study. 61
10366072 1999
11
[LASIK for myopia correction. 2-year follow-up]. 61
9738381 1998
12
[Laser in situ keratomileusis (LASIK) for correction of myopia]. 61
9465708 1997
13
Juvenile rhegmatogenous retinal detachment. 61
580955 1978

Variations for Myopia 15, Autosomal Dominant

Expression for Myopia 15, Autosomal Dominant

Search GEO for disease gene expression data for Myopia 15, Autosomal Dominant.

Pathways for Myopia 15, Autosomal Dominant

GO Terms for Myopia 15, Autosomal Dominant

Sources for Myopia 15, Autosomal Dominant

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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