MYP15
MCID: MYP146
MIFTS: 21

Myopia 15, Autosomal Dominant (MYP15)

Categories: Eye diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Myopia 15, Autosomal Dominant

MalaCards integrated aliases for Myopia 15, Autosomal Dominant:

Name: Myopia 15, Autosomal Dominant 56
Myopia 15 56 13 71
Myp15 56

Characteristics:

OMIM:

56
Inheritance:
autosomal dominant

Miscellaneous:
reported in a large hutterite family


HPO:

31
myopia 15, autosomal dominant:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 56 612717
OMIM Phenotypic Series 56 PS160700
MedGen 41 C2675180
SNOMED-CT via HPO 68 263681008 57190000
UMLS 71 C2675180

Summaries for Myopia 15, Autosomal Dominant

OMIM : 56 Myopia, or nearsightedness, is a refractive error of the eye. Light rays from a distant object are focused in front of the retina and those from a near object are focused in the retina; therefore distant objects are blurry and near objects are clear (summary by Kaiser et al., 2004). For a discussion of genetic heterogeneity of susceptibility to myopia, see 160700. (612717)

MalaCards based summary : Myopia 15, Autosomal Dominant, also known as myopia 15, is related to myopia and myopia 10. An important gene associated with Myopia 15, Autosomal Dominant is MYP15 (Myopia 15). The drugs Alkylating Agents and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include retina and eye, and related phenotype is myopia.

Related Diseases for Myopia 15, Autosomal Dominant

Symptoms & Phenotypes for Myopia 15, Autosomal Dominant

Human phenotypes related to Myopia 15, Autosomal Dominant:

31
# Description HPO Frequency HPO Source Accession
1 myopia 31 HP:0000545

Symptoms via clinical synopsis from OMIM:

56
Head And Neck Eyes:
myopia, high-grade (average refractive error -7.04 diopters)

Clinical features from OMIM:

612717

Drugs & Therapeutics for Myopia 15, Autosomal Dominant

Drugs for Myopia 15, Autosomal Dominant (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Alkylating Agents Phase 4
2 Anti-Bacterial Agents Phase 4
3 Antibiotics, Antitubercular Phase 4
4 Mitomycins Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of the Prophylactic Use of Mitomycin C 0.02% to Inhibit Haze Formation After Photorefractive Keratectomy for High Myopia: 15 x 30 Seconds Completed NCT00564213 Phase 4 PRK and a single intraoperative topical application of mitomycin C 0.02% for 15 seconds

Search NIH Clinical Center for Myopia 15, Autosomal Dominant

Genetic Tests for Myopia 15, Autosomal Dominant

Anatomical Context for Myopia 15, Autosomal Dominant

MalaCards organs/tissues related to Myopia 15, Autosomal Dominant:

40
Retina, Eye

Publications for Myopia 15, Autosomal Dominant

Articles related to Myopia 15, Autosomal Dominant:

(show all 12)
# Title Authors PMID Year
1
Genetic linkage study of high-grade myopia in a Hutterite population from South Dakota. 56
17327828 2007
2
Influence of vision on masticatory muscles function: surface electromyographic evaluation. 61
25002919 2014
3
Subfoveal choroidal thickness: the Beijing Eye Study. 61
23009895 2013
4
Severe hyperopic shift and irregular astigmatism after radial keratotomy. 61
19812501 2009
5
[Analysis of clinical features of choroidal neovascularization]. 61
19175155 2008
6
Inhibitory effects of apomorphine and atropine and their combination on myopia in chicks. 61
15127933 2004
7
Lincoff temporary balloon buckle in retinal detachment surgery. 61
11820310 2001
8
[Possibilities of special correction in restoration of reading capacity in poorly sighted patients]. 61
11765464 2001
9
Refractive errors in an older population: the Blue Mountains Eye Study. 61
10366072 1999
10
[LASIK for myopia correction. 2-year follow-up]. 61
9738381 1998
11
[Laser in situ keratomileusis (LASIK) for correction of myopia]. 61
9465708 1997
12
Juvenile rhegmatogenous retinal detachment. 61
580955 1978

Variations for Myopia 15, Autosomal Dominant

Expression for Myopia 15, Autosomal Dominant

Search GEO for disease gene expression data for Myopia 15, Autosomal Dominant.

Pathways for Myopia 15, Autosomal Dominant

GO Terms for Myopia 15, Autosomal Dominant

Sources for Myopia 15, Autosomal Dominant

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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