Aliases & Classifications for Myopia 1, X-Linked

MalaCards integrated aliases for Myopia 1, X-Linked:

Name: Myopia 1, X-Linked 56 13 71
Myopia-1 56
Myp1 56

Characteristics:

OMIM:

56
Inheritance:
x-linked recessive


HPO:

31
myopia 1, x-linked:
Inheritance x-linked inheritance x-linked recessive inheritance


External Ids:

OMIM 56 310460
OMIM Phenotypic Series 56 PS160700
MedGen 41 C1839612
SNOMED-CT via HPO 68 263934009 57190000
UMLS 71 C1839612

Summaries for Myopia 1, X-Linked

OMIM : 56 Myopia, or nearsightedness, is a refractive error of the eye. Light rays from a distant object are focused in front of the retina and those from a near object are focused in the retina; therefore distant objects are blurry and near objects are clear (summary by Kaiser et al., 2004). For a discussion of genetic heterogeneity of myopia, see 160700. (310460)

MalaCards based summary : Myopia 1, X-Linked, also known as myopia-1, is related to myopia and bornholm eye disease. An important gene associated with Myopia 1, X-Linked is MYP1 (Myopia 1 (X-Linked)). The drugs Aluminum hydroxide, magnesium hydroxide, simethicone drug combination and TEMPO have been mentioned in the context of this disorder. Affiliated tissues include retina and eye, and related phenotype is myopia.

Related Diseases for Myopia 1, X-Linked

Diseases in the Myopia 1, X-Linked family:

Myopia 13, X-Linked

Diseases related to Myopia 1, X-Linked via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 myopia 11.7
2 bornholm eye disease 11.6
3 eye disease 11.2
4 joint laxity, short stature, and myopia 10.6
5 myopia 13, x-linked 10.3
6 yemenite deaf-blind hypopigmentation syndrome 10.3
7 colorblindness, partial, deutan series 10.2

Graphical network of the top 20 diseases related to Myopia 1, X-Linked:



Diseases related to Myopia 1, X-Linked

Symptoms & Phenotypes for Myopia 1, X-Linked

Human phenotypes related to Myopia 1, X-Linked:

31
# Description HPO Frequency HPO Source Accession
1 myopia 31 HP:0000545

Symptoms via clinical synopsis from OMIM:

56
Head And Neck Eyes:
myopia

Clinical features from OMIM:

310460

Drugs & Therapeutics for Myopia 1, X-Linked

Drugs for Myopia 1, X-Linked (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Aluminum hydroxide, magnesium hydroxide, simethicone drug combination
2 TEMPO

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Proclear 1 Day Lens vs 1-Day Acuvue Moist Daily Disposable Contact Lens Crossover Study Completed NCT01155323
2 Clinical Trial of Several Contact Lenses in Extended Wear Completed NCT00762788
3 1•DAY ACUVUE® TruEye™ Brand Contact Lenses & 1•DAY ACUVUE® MOIST® Brand Contact Lenses With LACREON® TECHNOLOGY Daily Disposable Performance Overview Registry -TEMPO Study Completed NCT01467557
4 Safety and Efficacy Study of Macular Buckle With A Three-armed Silicone Capsule to Support the Posterior Staphyloma in High Myopia. Completed NCT02169635

Search NIH Clinical Center for Myopia 1, X-Linked

Genetic Tests for Myopia 1, X-Linked

Anatomical Context for Myopia 1, X-Linked

MalaCards organs/tissues related to Myopia 1, X-Linked:

40
Retina, Eye

Publications for Myopia 1, X-Linked

Articles related to Myopia 1, X-Linked:

(show all 16)
# Title Authors PMID Year
1
Refinement of the X-linked nonsyndromic high-grade myopia locus MYP1 on Xq28 and exclusion of 13 known positional candidate genes by direct sequencing. 61 56
21357393 2011
2
X-linked form of myopia. 56
7262894 1981
3
Hereditary myopia. 56
18141056 1949
4
Isolation and characterization of tambjamine MYP1, a macrocyclic tambjamine analogue from marine bacterium Pseudoalteromonas citrea. 61
31015911 2019
5
Collective Molecular Mechanisms in the CH3NH3PbI3 Dissolution by Liquid Water. 61
28783296 2017
6
Unique Variants in OPN1LW Cause Both Syndromic and Nonsyndromic X-Linked High Myopia Mapped to MYP1. 61
26114493 2015
7
NYX mutations in four families with high myopia with or without CSNB1. 61
25802485 2015
8
Nonsyndromic high myopia in a Chinese family mapped to MYP1: linkage confirmation and phenotypic characterization. 61
21060050 2010
9
Etiopathogenesis and management of high myopia. Part II. 61
19865068 2009
10
An international collaborative family-based whole-genome linkage scan for high-grade myopia. 61
19324860 2009
11
Evaluation of the X-linked high-grade myopia locus (MYP1) with cone dysfunction and color vision deficiencies. 61
19098318 2009
12
A single nucleotide polymorphism analysis of the LAMA1 gene in Japanese patients with high myopia. 61
19668483 2007
13
Confirmation of a genetic locus for X-linked recessive high myopia outside MYP1. 61
17351708 2007
14
Novel locus for X linked recessive high myopia maps to Xq23-q25 but outside MYP1. 61
16648373 2006
15
X-linked high myopia associated with cone dysfunction. 61
15197065 2004
16
Mutations in the myp1 gene of Ustilago maydis attenuate mycelial growth and virulence. 61
8647387 1995

Variations for Myopia 1, X-Linked

Expression for Myopia 1, X-Linked

Search GEO for disease gene expression data for Myopia 1, X-Linked.

Pathways for Myopia 1, X-Linked

GO Terms for Myopia 1, X-Linked

Sources for Myopia 1, X-Linked

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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