Aliases & Classifications for Myositis Fibrosa

MalaCards integrated aliases for Myositis Fibrosa:

Name: Myositis Fibrosa 12 15
Interstitial Myositis 12 72 33

Classifications:



External Ids:

Disease Ontology 12 DOID:9788
ICD9CM 35 728.81
NCIt 50 C26985
SNOMED-CT 68 55925001
ICD10 33 M60.1
UMLS 72 C0158362

Summaries for Myositis Fibrosa

MalaCards based summary : Myositis Fibrosa, also known as interstitial myositis, is related to autoimmune disease and ulcerative colitis, and has symptoms including generalized muscle weakness and spasm. An important gene associated with Myositis Fibrosa is GAP43 (Growth Associated Protein 43), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Related phenotypes are cellular and hematopoietic system

Related Diseases for Myositis Fibrosa

Diseases related to Myositis Fibrosa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
# Related Disease Score Top Affiliating Genes
1 autoimmune disease 28.9 TLR9 IL17A IFNG
2 ulcerative colitis 28.6 TLR4 IL17A IFNG
3 colitis 28.2 TLR9 TLR4 IL17A IFNG
4 inflammatory bowel disease 28.1 TLR4 TLR2 IL17A IFNG
5 myositis 10.6
6 virus associated hemophagocytic syndrome 10.6 PIK3C2A MB
7 interstitial myocarditis 10.5 PIK3C2A MB
8 creatine phosphokinase, elevated serum 10.5 PIK3C2A MB
9 posterior myocardial infarction 10.5 PIK3C2A MB
10 gas gangrene 10.5 PIK3C2A MB
11 anuria 10.5 PIK3C2A MB
12 compartment syndrome 10.4 PIK3C2A MB
13 plexopathy 10.4 PIK3C2A MB
14 neuroleptic malignant syndrome 10.4 PIK3C2A MB
15 sulfamethoxazole allergy 10.3 CD86 CD80
16 mesenteric lymphadenitis 10.3 TLR2 MYD88
17 filarial elephantiasis 10.2 TLR9 TLR2
18 type 1 diabetes mellitus 13 10.2 CD86 CD80
19 prosthetic joint infection 10.2 TLR4 TLR2
20 type 1 diabetes mellitus 6 10.2 CD86 CD80
21 trench fever 10.2 TLR4 TLR2
22 intermediate coronary syndrome 10.2 PIK3C2A MB
23 fungal keratitis 10.2 TLR4 TLR2
24 septicemic plague 10.2 MYD88 IL17A
25 ocular toxoplasmosis 10.1 TLR9 IL17A
26 neurosyphilis 10.1 TLR2 IL17A
27 neisseria meningitidis infection 10.1 TLR4 TLR2
28 viral pneumonia 10.1 TLR9 IL17A
29 bacterial meningitis 10.1 TLR9 TLR2 PIK3C2A
30 stiff-person syndrome 10.0
31 inflammatory spondylopathy 10.0
32 spondylitis 10.0
33 autoimmune peripheral neuropathy 10.0 CD86 CD80
34 autoimmune disease of eyes, ear, nose and throat 10.0 TLR9 IL17A
35 muscular disease 10.0 TLR9 PIK3C2A MB
36 alveolar echinococcosis 10.0 TLR4 TLR2
37 cystic echinococcosis 10.0 TLR4 IL17A
38 dermatomyositis 10.0
39 polymyositis 10.0
40 myd88 deficiency 9.9 TLR4 TLR2 MYD88
41 irak4 deficiency 9.9 TLR4 TLR2 MYD88
42 acute cervicitis 9.9 TLR4 TLR2 CD86
43 penicilliosis 9.9 TLR4 TLR2 CD86
44 suppurative otitis media 9.9 TLR9 TLR4 TLR2
45 septic arthritis 9.9 TLR9 TLR4 TLR2
46 middle ear disease 9.9 TLR9 TLR4 TLR2
47 variola major 9.9 TLR4 IFNG
48 cutis laxa, autosomal dominant 1 9.9 TLR9 TLR2 CD80
49 campylobacteriosis 9.8 TLR4 IFNG
50 hyper ige syndrome 9.8 TLR2 IFNG

Graphical network of the top 20 diseases related to Myositis Fibrosa:



Diseases related to Myositis Fibrosa

Symptoms & Phenotypes for Myositis Fibrosa

UMLS symptoms related to Myositis Fibrosa:


generalized muscle weakness, spasm

MGI Mouse Phenotypes related to Myositis Fibrosa:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.18 CD80 CD86 GAP43 IFNG MB MYD88
2 hematopoietic system MP:0005397 10.1 CD80 CD86 IFNG IL17A MB MYD88
3 growth/size/body region MP:0005378 10.09 CHL1 GAP43 IFNG IL17A MB MYD88
4 homeostasis/metabolism MP:0005376 10.02 CD86 IFNG IL17A MB MYD88 PIK3C2A
5 immune system MP:0005387 9.97 CD80 CD86 IFNG IL17A MYD88 PIK3C2A
6 digestive/alimentary MP:0005381 9.93 IFNG IL17A MYD88 TLR2 TLR4 TLR9
7 mortality/aging MP:0010768 9.91 GAP43 IFNG IL17A MB MYD88 PIK3C2A
8 nervous system MP:0003631 9.76 CD80 CD86 CHL1 GAP43 IFNG MYD88
9 renal/urinary system MP:0005367 9.5 IFNG IL17A MYD88 PIK3C2A TLR2 TLR4
10 respiratory system MP:0005388 9.17 CHL1 IFNG IL17A MB MYD88 TLR2

Drugs & Therapeutics for Myositis Fibrosa

Search Clinical Trials , NIH Clinical Center for Myositis Fibrosa

Genetic Tests for Myositis Fibrosa

Anatomical Context for Myositis Fibrosa

Publications for Myositis Fibrosa

Articles related to Myositis Fibrosa:

(show all 45)
# Title Authors PMID Year
1
Necrotizing streptococcal myositis of the upper extremity: a case report. 38
28807000 2017
2
Focal myositis of lower extremity responsive to botulinum A toxin. 38
24614669 2014
3
[Chronic recurrent multifocal osteomyelitis with interstitial myositis]. 38
23445733 2013
4
Toll-like receptors promote inflammation in idiopathic inflammatory myopathies. 38
22964787 2012
5
Incidence and prevalence of idiopathic inflammatory myopathies among commercially insured, Medicare supplemental insured, and Medicaid enrolled populations: an administrative claims analysis. 38
22703603 2012
6
Epidemiology of adult idiopathic inflammatory myopathies in a U.S. managed care plan. 38
22499094 2012
7
Development of lesions and tissue distribution of parasite in lambs orally infected with sporulated oocysts of Toxoplasma gondii. 38
21440372 2011
8
Subacute cutaneous lupus erythematosus and interstitial myositis occurring with hepatitis B infection: response to antiviral therapy with lamivudine. 38
18664991 2008
9
Streptococcus pneumoniae-associated cellulitis in a two-month-old Domestic Shorthair kitten. 38
16617709 2006
10
Muscle involvement in leprosy. Study of the anterior tibial muscle in 40 patients. 38
10751905 1999
11
[Freund's complete adjuvant in the chicken: efficient immunostimulation with severe local inflammatory reaction]. 38
8767734 1996
12
[A case of toxoplasmosis with dermatomyositis]. 38
8708414 1995
13
Myopathological findings in interstitial myositis in type II polyendocrine autoimmune syndrome (Schmidt's syndrome). 38
7643982 1995
14
A patient with one limb interstitial myositis with localised lipoatrophy presenting with severe cramps and fasciculations. 38
7798989 1994
15
The pathology of experimental Trypanosoma evansi infection in the Indonesian buffalo (Bubalus bubalis). 38
8040389 1994
16
Expression of growth associated protein 43 and neural cell adhesion molecule in congenital fibre type disproportion with interstitial myositis. 38
7522852 1994
17
The NIH-3 immunodeficient mouse is a model for Lyme borreliosis myositis and carditis. 38
1632468 1992
18
[L-tryptophan-associated chronic eosinophilia-myalgia syndrome treated with cyclosporin]. 38
1414039 1992
19
[Camptocormia in the elderly. A new entity by paravertebral muscle involvement?]. 38
1609234 1992
20
[Eosinophilia-myalgia syndrome with fasciitis and interstitial myositis after L-tryptophan administration]. 38
1574934 1992
21
Eosinophilia-myalgia syndrome (L-tryptophan-associated neuromyopathy). 38
2234439 1990
22
L-tryptophan-associated eosinophilic perimyositis, neuritis, and fasciitis. A clinicopathologic and laboratory study of 25 patients. 38
2374505 1990
23
[Acute trichinosis. 193 cases in an epidemic]. 38
3678092 1987
24
[Necrotizing vasculitis with interstitial myositis localized in the calf: a new case]. 38
3423482 1987
25
Ulcerative colitis and interstitial myositis. 38
3690930 1987
26
The diagnostic significance of large action potentials in myopathy. 38
6644325 1983
27
Multifocal interstitial myositis associated with localized lipoatrophy: a benign course. 38
7126001 1982
28
[Value of myometric findings in the morphological differential diagnosis of neuromuscular disorders (author's transl)]. 38
6931279 1980
29
[Granulomatous myositis during collagenosis (one case) and suprasellar dysgerminoma (one case) (author's transl)]. 38
482759 1979
30
A case of leprous nodular interstitial myositis. 38
4348227 1972
31
Myositis fibrosa generalisata and 'stiff-man' syndrome. 38
5265048 1970
32
[Periocular primary interstitial myositis]. 38
5398791 1969
33
[On myositis fibrosa]. 38
5842765 1965
34
[Myositis fibrosa. Successful treatment of a case with severe contractures of the lower extremity with steroid hormones and surgery]. 38
13866655 1961
35
Chronic myositis fibrosa: report of a case. 38
13833972 1959
36
[Interstitial myositis of the orbiculus ciliaris]. 38
14351945 1954
37
[Generalized myositis fibrosa; nosologic considerations and therapy]. 38
13057631 1953
38
Myositis fibrosa generalisata. 38
14857789 1951
39
Generalized Myositis Fibrosa. 38
18623809 1949
40
MYOSITIS FIBROSA PROGRESSIVA. 38
20775528 1930
41
Sclerodermia with Myositis Fibrosa. 38
19976382 1912
42
Sclerema Neonatorum, with Myositis Fibrosa. 38
19975506 1911
43
Spondylitis, with Progressive Muscular Contracture (? Myositis Fibrosa). 38
19974892 1911
44
(?) Myositis Fibrosa. 38
19974719 1910
45
XIII. Excision of the Scapula for Progressive Chronic Interstitial Myositis associated with Obliterating Endarteritis. 38
17861315 1903

Variations for Myositis Fibrosa

Expression for Myositis Fibrosa

Search GEO for disease gene expression data for Myositis Fibrosa.

Pathways for Myositis Fibrosa

Pathways related to Myositis Fibrosa according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 TLR9 TLR4 TLR2 MYD88 IL17A IFNG
2
Show member pathways
13.25 TLR9 TLR4 TLR2 MYD88 IL17A CD80
3
Show member pathways
13.06 TLR9 TLR4 TLR2 PIK3C2A MYD88 IFNG
4
Show member pathways
12.8 TLR9 TLR4 TLR2 MYD88 IFNG CD86
5
Show member pathways
12.57 TLR9 TLR4 TLR2 MYD88
6
Show member pathways
12.48 TLR9 TLR4 TLR2 MYD88
7
Show member pathways
12.43 TLR4 TLR2 IL17A IFNG CD86
8 12.39 TLR9 TLR2 MYD88 IL17A IFNG
9
Show member pathways
12.29 TLR9 TLR4 TLR2 MYD88
10
Show member pathways
12.15 TLR9 TLR4 TLR2 MYD88
11
Show member pathways
12.13 TLR4 TLR2 MYD88 IFNG
12
Show member pathways
12.07 TLR9 TLR4 TLR2 MYD88
13 12.05 TLR9 TLR4 TLR2 IFNG
14 12.02 TLR9 TLR4 TLR2 MYD88 IFNG
15
Show member pathways
11.92 TLR4 TLR2 IFNG
16 11.89 TLR4 IFNG GAP43
17 11.87 IFNG CD86 CD80
18
Show member pathways
11.87 TLR9 TLR4 TLR2 MYD88 IFNG
19
Show member pathways
11.85 TLR9 TLR4 TLR2 PIK3C2A
20 11.81 TLR4 TLR2 IFNG
21
Show member pathways
11.76 TLR4 MYD88 IL17A
22 11.7 TLR9 TLR4 TLR2
23 11.69 TLR4 MYD88 IFNG
24 11.56 IL17A IFNG CD86 CD80
25 11.51 TLR4 TLR2 MYD88
26 11.43 TLR4 TLR2 IFNG
27 11.4 TLR4 TLR2 IL17A IFNG CD86 CD80
28 11.39 IFNG CD86 CD80
29
Show member pathways
11.28 TLR9 TLR4 TLR2 IL17A IFNG CD86
30 11.27 TLR9 MYD88 IFNG
31 11.24 TLR9 TLR4 TLR2 MYD88 IFNG
32 11.2 IFNG CD86 CD80
33 11.17 IL17A IFNG
34 11.01 TLR2 MYD88 IFNG
35 10.98 TLR2 MYD88

GO Terms for Myositis Fibrosa

Cellular components related to Myositis Fibrosa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.61 TLR9 TLR4 TLR2 PIK3C2A MYD88 GAP43
2 external side of plasma membrane GO:0009897 8.92 TLR4 IL17A CD86 CD80

Biological processes related to Myositis Fibrosa according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.99 TLR9 TLR4 TLR2 MYD88 IFNG
2 inflammatory response GO:0006954 9.97 TLR9 TLR4 TLR2 MYD88 IL17A
3 cytokine-mediated signaling pathway GO:0019221 9.95 MYD88 IL17A CD86 CD80
4 cell surface receptor signaling pathway GO:0007166 9.93 MYD88 IFNG CD86 CD80
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 TLR9 TLR4 TLR2 MYD88
6 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.87 TLR9 TLR4 MYD88
7 response to lipopolysaccharide GO:0032496 9.87 TLR4 TLR2 MYD88
8 cellular response to lipopolysaccharide GO:0071222 9.86 TLR4 CD86 CD80
9 positive regulation of JNK cascade GO:0046330 9.83 TLR9 TLR4 MYD88
10 positive regulation of inflammatory response GO:0050729 9.82 TLR9 TLR4 TLR2
11 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.78 TLR9 TLR4 TLR2
12 lipopolysaccharide-mediated signaling pathway GO:0031663 9.76 TLR4 TLR2 MYD88
13 positive regulation of interleukin-6 production GO:0032755 9.73 TLR9 TLR4 TLR2 MYD88
14 positive regulation of interferon-beta production GO:0032728 9.72 TLR9 TLR4 TLR2
15 positive regulation of interleukin-10 production GO:0032733 9.71 TLR9 TLR4 TLR2
16 positive regulation of tumor necrosis factor production GO:0032760 9.71 TLR9 TLR4 TLR2 MYD88
17 negative regulation of interleukin-6 production GO:0032715 9.7 TLR9 TLR4
18 positive regulation of chemokine production GO:0032722 9.7 TLR9 TLR4 TLR2
19 immune response GO:0006955 9.7 TLR9 TLR4 TLR2 IL17A IFNG CD86
20 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.69 TLR4 MYD88 IL17A
21 positive regulation of osteoclast differentiation GO:0045672 9.68 IL17A IFNG
22 toll-like receptor 9 signaling pathway GO:0034162 9.68 TLR9 MYD88
23 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.68 CD86 CD80
24 response to molecule of bacterial origin GO:0002237 9.67 TLR9 TLR2
25 negative regulation of interleukin-17 production GO:0032700 9.67 TLR4 IFNG
26 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.67 TLR9 TLR4
27 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.67 TLR9 TLR4 TLR2
28 toll-like receptor signaling pathway GO:0002224 9.67 TLR9 TLR4 TLR2 MYD88
29 cellular response to lipoteichoic acid GO:0071223 9.66 TLR4 TLR2
30 positive regulation of lymphocyte proliferation GO:0050671 9.66 TLR4 MYD88
31 positive regulation of interferon-beta biosynthetic process GO:0045359 9.64 TLR9 TLR4
32 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.64 TLR4 MYD88
33 I-kappaB phosphorylation GO:0007252 9.63 TLR9 TLR4 TLR2
34 tumor necrosis factor production GO:0032640 9.62 TLR9 TLR2
35 positive regulation of interleukin-18 production GO:0032741 9.61 TLR9 TLR2
36 positive regulation of toll-like receptor signaling pathway GO:0034123 9.6 TLR9 TLR2
37 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.56 TLR4 TLR2
38 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.56 TLR9 TLR4 TLR2 MYD88
39 positive regulation of interleukin-23 production GO:0032747 9.5 MYD88 IL17A IFNG
40 regulation of cytokine secretion GO:0050707 9.48 TLR9 TLR2
41 phosphatidylinositol phosphorylation GO:0046854 9.38 PIK3C2A
42 positive regulation of interleukin-8 production GO:0032757 9.26 TLR9 TLR4 TLR2 MYD88
43 positive regulation of interleukin-12 production GO:0032735 8.92 TLR9 TLR4 TLR2 IFNG
44 signal transduction GO:0007165 10.18 TLR9 TLR4 TLR2 MYD88 CHL1 CD86
45 immune system process GO:0002376 10.02 TLR9 TLR4 TLR2 MYD88 CD86
46 innate immune response GO:0045087 10 TLR9 TLR4 TLR2 MYD88

Molecular functions related to Myositis Fibrosa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 9.26 TLR9 MYD88
2 signaling pattern recognition receptor activity GO:0008329 9.16 TLR9 TLR2
3 Toll-like receptor binding GO:0035325 8.96 TLR2 MYD88
4 lipopolysaccharide receptor activity GO:0001875 8.62 TLR4 TLR2

Sources for Myositis Fibrosa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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