Aliases & Classifications for Myositis Fibrosa

MalaCards integrated aliases for Myositis Fibrosa:

Name: Myositis Fibrosa 12 15
Interstitial Myositis 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:9788
ICD9CM 36 728.81
NCIt 51 C26985
SNOMED-CT 69 55925001
ICD10 34 M60.1
UMLS 74 C0158362

Summaries for Myositis Fibrosa

MalaCards based summary : Myositis Fibrosa, also known as interstitial myositis, is related to ulcerative colitis and colitis, and has symptoms including generalized muscle weakness and spasm. An important gene associated with Myositis Fibrosa is GAP43 (Growth Associated Protein 43), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Affiliated tissues include bone and eye, and related phenotypes are cellular and hematopoietic system

Related Diseases for Myositis Fibrosa

Diseases related to Myositis Fibrosa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)
# Related Disease Score Top Affiliating Genes
1 ulcerative colitis 29.0 IFNG IL17A TLR4
2 colitis 28.8 IFNG IL17A TLR4 TLR9
3 myositis 10.5
4 virus associated hemophagocytic syndrome 10.3 MB PIK3C2A
5 interstitial myocarditis 10.3 MB PIK3C2A
6 creatine phosphokinase, elevated serum 10.3 MB PIK3C2A
7 posterior myocardial infarction 10.3 MB PIK3C2A
8 gas gangrene 10.3 MB PIK3C2A
9 anuria 10.3 MB PIK3C2A
10 neuroleptic malignant syndrome 10.2 MB PIK3C2A
11 plexopathy 10.2 MB PIK3C2A
12 compartment syndrome 10.2 MB PIK3C2A
13 filarial elephantiasis 10.2 TLR2 TLR9
14 mesenteric lymphadenitis 10.2 MYD88 TLR2
15 sulfamethoxazole allergy 10.1 CD80 CD86
16 prosthetic joint infection 10.1 TLR2 TLR4
17 trench fever 10.1 TLR2 TLR4
18 type 1 diabetes mellitus 13 10.1 CD80 CD86
19 type 1 diabetes mellitus 6 10.1 CD80 CD86
20 fungal keratitis 10.1 TLR2 TLR4
21 ocular toxoplasmosis 10.1 IL17A TLR9
22 septicemic plague 10.1 IL17A MYD88
23 viral pneumonia 10.1 IL17A TLR9
24 bacterial meningitis 10.1 PIK3C2A TLR2 TLR9
25 neurosyphilis 10.1 IL17A TLR2
26 autoimmune disease of eyes, ear, nose and throat 10.1 IL17A TLR9
27 spondylitis 10.1
28 neisseria meningitidis infection 10.0 TLR2 TLR4
29 legionnaires' disease 10.0 PIK3C2A TLR4 TLR9
30 intermediate coronary syndrome 10.0 MB PIK3C2A
31 muscular disease 10.0 MB PIK3C2A TLR9
32 autoimmune peripheral neuropathy 10.0 CD80 CD86
33 alveolar echinococcosis 10.0 TLR2 TLR4
34 cystic echinococcosis 10.0 IL17A TLR4
35 irak4 deficiency 10.0 MYD88 TLR2 TLR4
36 myd88 deficiency 10.0 MYD88 TLR2 TLR4
37 suppurative otitis media 10.0 TLR2 TLR4 TLR9
38 septic arthritis 10.0 TLR2 TLR4 TLR9
39 middle ear disease 10.0 TLR2 TLR4 TLR9
40 cutis laxa, autosomal dominant 1 9.9 CD80 TLR2 TLR9
41 acute cervicitis 9.9 CD86 TLR2 TLR4
42 penicilliosis 9.9 CD86 TLR2 TLR4
43 variola major 9.9 IFNG TLR4
44 campylobacteriosis 9.9 IFNG TLR4
45 hyper ige syndrome 9.9 IFNG TLR2
46 spondylarthropathy 9.9 CD80 TLR2 TLR4
47 trichosporonosis 9.9 IFNG IL17A
48 bacterial pneumonia 9.8 IL17A TLR4 TLR9
49 lichen disease 9.8 IFNG TLR9
50 plasmodium falciparum malaria 9.8 IFNG MB TLR9

Graphical network of the top 20 diseases related to Myositis Fibrosa:



Diseases related to Myositis Fibrosa

Symptoms & Phenotypes for Myositis Fibrosa

UMLS symptoms related to Myositis Fibrosa:


generalized muscle weakness, spasm

MGI Mouse Phenotypes related to Myositis Fibrosa:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.18 CD80 CD86 GAP43 IFNG MB MYD88
2 hematopoietic system MP:0005397 10.1 CD80 CD86 IFNG IL17A MB MYD88
3 growth/size/body region MP:0005378 10.09 CHL1 GAP43 IFNG IL17A MB MYD88
4 homeostasis/metabolism MP:0005376 10.02 CD86 IFNG IL17A MB MYD88 PIK3C2A
5 immune system MP:0005387 9.97 CD80 CD86 IFNG IL17A MYD88 PIK3C2A
6 digestive/alimentary MP:0005381 9.93 IFNG IL17A MYD88 TLR2 TLR4 TLR9
7 mortality/aging MP:0010768 9.91 GAP43 IFNG IL17A MB MYD88 PIK3C2A
8 nervous system MP:0003631 9.76 CD80 CD86 CHL1 GAP43 IFNG MYD88
9 renal/urinary system MP:0005367 9.5 IFNG IL17A MYD88 PIK3C2A TLR2 TLR4
10 respiratory system MP:0005388 9.17 CHL1 IFNG IL17A MB MYD88 TLR2

Drugs & Therapeutics for Myositis Fibrosa

Search Clinical Trials , NIH Clinical Center for Myositis Fibrosa

Genetic Tests for Myositis Fibrosa

Anatomical Context for Myositis Fibrosa

MalaCards organs/tissues related to Myositis Fibrosa:

42
Bone, Eye

Publications for Myositis Fibrosa

Articles related to Myositis Fibrosa:

(show all 17)
# Title Authors Year
1
Subacute cutaneous lupus erythematosus and interstitial myositis occurring with hepatitis B infection: response to antiviral therapy with lamivudine. ( 18664991 )
2008
2
Myopathological findings in interstitial myositis in type II polyendocrine autoimmune syndrome (Schmidt's syndrome). ( 7643982 )
1995
3
Expression of growth associated protein 43 and neural cell adhesion molecule in congenital fibre type disproportion with interstitial myositis. ( 7522852 )
1994
4
A patient with one limb interstitial myositis with localised lipoatrophy presenting with severe cramps and fasciculations. ( 7798989 )
1994
5
Ulcerative colitis and interstitial myositis. ( 3690930 )
1987
6
Multifocal interstitial myositis associated with localized lipoatrophy: a benign course. ( 7126001 )
1982
7
A case of leprous nodular interstitial myositis. ( 4348227 )
1972
8
Myositis fibrosa generalisata and 'stiff-man' syndrome. ( 5265048 )
1970
9
Chronic myositis fibrosa: report of a case. ( 13833972 )
1959
10
Myositis fibrosa generalisata. ( 14857789 )
1951
11
Generalized Myositis Fibrosa. ( 18623809 )
1949
12
MYOSITIS FIBROSA PROGRESSIVA. ( 20775528 )
1930
13
Sclerodermia with Myositis Fibrosa. ( 19976382 )
1912
14
Spondylitis, with Progressive Muscular Contracture (? Myositis Fibrosa). ( 19974892 )
1911
15
Sclerema Neonatorum, with Myositis Fibrosa. ( 19975506 )
1911
16
(?) Myositis Fibrosa. ( 19974719 )
1910
17
XIII. Excision of the Scapula for Progressive Chronic Interstitial Myositis associated with Obliterating Endarteritis. ( 17861315 )
1903

Variations for Myositis Fibrosa

Expression for Myositis Fibrosa

Search GEO for disease gene expression data for Myositis Fibrosa.

Pathways for Myositis Fibrosa

Pathways related to Myositis Fibrosa according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 CD80 CD86 IFNG IL17A MYD88 TLR2
2
Show member pathways
13.25 CD80 IL17A MYD88 TLR2 TLR4 TLR9
3
Show member pathways
13.06 IFNG MYD88 PIK3C2A TLR2 TLR4 TLR9
4
Show member pathways
12.8 CD80 CD86 IFNG MYD88 TLR2 TLR4
5
Show member pathways
12.57 MYD88 TLR2 TLR4 TLR9
6
Show member pathways
12.48 MYD88 TLR2 TLR4 TLR9
7
Show member pathways
12.43 CD86 IFNG IL17A TLR2 TLR4
8 12.39 IFNG IL17A MYD88 TLR2 TLR9
9
Show member pathways
12.29 MYD88 TLR2 TLR4 TLR9
10
Show member pathways
12.15 MYD88 TLR2 TLR4 TLR9
11
Show member pathways
12.13 IFNG MYD88 TLR2 TLR4
12
Show member pathways
12.07 MYD88 TLR2 TLR4 TLR9
13 12.05 IFNG TLR2 TLR4 TLR9
14 12.02 IFNG MYD88 TLR2 TLR4 TLR9
15
Show member pathways
11.92 IFNG TLR2 TLR4
16 11.89 GAP43 IFNG TLR4
17 11.87 CD80 CD86 IFNG
18
Show member pathways
11.87 IFNG MYD88 TLR2 TLR4 TLR9
19
Show member pathways
11.85 PIK3C2A TLR2 TLR4 TLR9
20 11.78 IFNG TLR2 TLR4
21
Show member pathways
11.76 IL17A MYD88 TLR4
22 11.72 IFNG MYD88 TLR4
23 11.7 TLR2 TLR4 TLR9
24 11.56 CD80 CD86 IFNG IL17A
25 11.5 MYD88 TLR2 TLR4
26 11.43 IFNG TLR2 TLR4
27 11.39 CD80 CD86 IFNG
28 11.39 CD80 CD86 IFNG IL17A TLR2 TLR4
29
Show member pathways
11.28 CD80 CD86 IFNG IL17A TLR2 TLR4
30 11.27 IFNG MYD88 TLR9
31 11.24 IFNG MYD88 TLR2 TLR4 TLR9
32 11.2 CD80 CD86 IFNG
33 11.17 IFNG IL17A
34 11.01 IFNG MYD88 TLR2
35 10.98 MYD88 TLR2

GO Terms for Myositis Fibrosa

Cellular components related to Myositis Fibrosa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.61 CD80 CD86 CHL1 GAP43 MYD88 PIK3C2A
2 external side of plasma membrane GO:0009897 8.92 CD80 CD86 IL17A TLR4

Biological processes related to Myositis Fibrosa according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.99 IFNG MYD88 TLR2 TLR4 TLR9
2 inflammatory response GO:0006954 9.97 IL17A MYD88 TLR2 TLR4 TLR9
3 cytokine-mediated signaling pathway GO:0019221 9.95 CD80 CD86 IL17A MYD88
4 cell surface receptor signaling pathway GO:0007166 9.93 CD80 CD86 IFNG MYD88
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 MYD88 TLR2 TLR4 TLR9
6 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.87 MYD88 TLR4 TLR9
7 response to lipopolysaccharide GO:0032496 9.87 MYD88 TLR2 TLR4
8 cellular response to lipopolysaccharide GO:0071222 9.86 CD80 CD86 TLR4
9 positive regulation of JNK cascade GO:0046330 9.83 MYD88 TLR4 TLR9
10 positive regulation of inflammatory response GO:0050729 9.82 TLR2 TLR4 TLR9
11 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.78 TLR2 TLR4 TLR9
12 lipopolysaccharide-mediated signaling pathway GO:0031663 9.76 MYD88 TLR2 TLR4
13 positive regulation of interleukin-6 production GO:0032755 9.73 MYD88 TLR2 TLR4 TLR9
14 positive regulation of interferon-beta production GO:0032728 9.72 TLR2 TLR4 TLR9
15 positive regulation of interleukin-10 production GO:0032733 9.71 TLR2 TLR4 TLR9
16 positive regulation of tumor necrosis factor production GO:0032760 9.71 MYD88 TLR2 TLR4 TLR9
17 negative regulation of interleukin-6 production GO:0032715 9.7 TLR4 TLR9
18 positive regulation of chemokine production GO:0032722 9.7 TLR2 TLR4 TLR9
19 immune response GO:0006955 9.7 CD80 CD86 IFNG IL17A TLR2 TLR4
20 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.69 IL17A MYD88 TLR4
21 positive regulation of osteoclast differentiation GO:0045672 9.68 IFNG IL17A
22 toll-like receptor 9 signaling pathway GO:0034162 9.68 MYD88 TLR9
23 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.68 CD80 CD86
24 negative regulation of interleukin-17 production GO:0032700 9.67 IFNG TLR4
25 response to molecule of bacterial origin GO:0002237 9.67 TLR2 TLR9
26 cellular response to lipoteichoic acid GO:0071223 9.67 TLR2 TLR4
27 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.67 TLR2 TLR4 TLR9
28 toll-like receptor signaling pathway GO:0002224 9.67 MYD88 TLR2 TLR4 TLR9
29 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.66 TLR4 TLR9
30 positive regulation of lymphocyte proliferation GO:0050671 9.66 MYD88 TLR4
31 regulation of cytokine secretion GO:0050707 9.65 TLR2 TLR4 TLR9
32 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.64 MYD88 TLR4
33 positive regulation of interferon-beta biosynthetic process GO:0045359 9.64 TLR4 TLR9
34 I-kappaB phosphorylation GO:0007252 9.63 TLR2 TLR4 TLR9
35 positive regulation of interleukin-18 production GO:0032741 9.62 TLR2 TLR9
36 tumor necrosis factor production GO:0032640 9.61 TLR2 TLR9
37 positive regulation of toll-like receptor signaling pathway GO:0034123 9.6 TLR2 TLR9
38 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.56 TLR2 TLR4
39 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.56 MYD88 TLR2 TLR4 TLR9
40 positive regulation of interleukin-23 production GO:0032747 9.5 IFNG IL17A MYD88
41 phosphatidylinositol phosphorylation GO:0046854 9.38 PIK3C2A
42 positive regulation of interleukin-8 production GO:0032757 9.26 MYD88 TLR2 TLR4 TLR9
43 positive regulation of interleukin-12 production GO:0032735 8.92 IFNG TLR2 TLR4 TLR9
44 signal transduction GO:0007165 10.18 CD80 CD86 CHL1 MYD88 TLR2 TLR4
45 immune system process GO:0002376 10.02 CD86 MYD88 TLR2 TLR4 TLR9
46 innate immune response GO:0045087 10 MYD88 TLR2 TLR4 TLR9

Molecular functions related to Myositis Fibrosa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 9.26 MYD88 TLR9
2 signaling pattern recognition receptor activity GO:0008329 9.16 TLR2 TLR9
3 Toll-like receptor binding GO:0035325 8.96 MYD88 TLR2
4 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4

Sources for Myositis Fibrosa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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