MCID: MYS001
MIFTS: 42

Myositis Ossificans

Categories: Muscle diseases

Aliases & Classifications for Myositis Ossificans

MalaCards integrated aliases for Myositis Ossificans:

Name: Myositis Ossificans 12 77 15 74
Ossification - Muscle 12
Myisitis Ossificans 12

Classifications:



External Ids:

Disease Ontology 12 DOID:668
MeSH 45 D009221
NCIt 51 C3253
SNOMED-CT 69 44551007
UMLS 74 C0027122

Summaries for Myositis Ossificans

Disease Ontology : 12 A myositis that is accompanied by ossification of muscle tissue or bony deposits in the muscles.

MalaCards based summary : Myositis Ossificans, also known as ossification - muscle, is related to fibrodysplasia ossificans progressiva and myositis. An important gene associated with Myositis Ossificans is USP6 (Ubiquitin Specific Peptidase 6), and among its related pathways/superpathways are TGF-beta signaling pathway (KEGG) and Transcription_Role of VDR in regulation of genes involved in osteoporosis. The drugs Tretinoin and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and spinal cord, and related phenotypes are craniofacial and mortality/aging

Wikipedia : 77 Myositis ossificans comprises two syndromes characterized by heterotopic ossification (calcification) of... more...

Related Diseases for Myositis Ossificans

Diseases related to Myositis Ossificans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 fibrodysplasia ossificans progressiva 33.2 ACVR1 BMP1 FOS
2 myositis 11.4
3 osseous heteroplasia, progressive 11.4
4 tetanus 10.5
5 sarcoma 10.5
6 aneurysmal bone cysts 10.3
7 poliomyelitis 10.3
8 spondylitis 10.3
9 osteogenic sarcoma 10.2
10 osteoid osteoma 10.2
11 ankylosis 10.2
12 spondyloarthropathy 1 10.1
13 cherubism 10.1
14 chondrosarcoma 10.1
15 arthritis 10.1
16 osteomyelitis 10.1
17 dermatomyositis 10.1
18 ischemia 10.1
19 extraosseous osteosarcoma 10.1
20 juxtacortical osteosarcoma 10.1
21 compartment syndrome 10.1
22 hemophilia 10.1
23 soft tissue sarcoma 10.1
24 burkitt lymphoma 10.0
25 breast cancer 10.0
26 lipomatosis, multiple 10.0
27 mccune-albright syndrome 10.0
28 radioulnar synostosis 10.0
29 thrombocytopenic purpura, autoimmune 10.0
30 triiodothyronine receptor auxiliary protein 10.0
31 sarcoma, synovial 10.0
32 alveolar soft part sarcoma 10.0
33 niemann-pick disease, type b 10.0
34 aplastic anemia 10.0
35 chromosome 16p13.3 deletion syndrome, proximal 10.0
36 factor xi deficiency 10.0
37 gastric cancer 10.0
38 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 10.0
39 cerebral palsy 10.0
40 childhood type dermatomyositis 10.0
41 leukemia 10.0
42 niemann-pick disease 10.0
43 spinal cord injury 10.0
44 lymphoma 10.0
45 scoliosis 10.0
46 thrombosis 10.0
47 fibrous dysplasia 10.0
48 spindle cell lipoma 10.0
49 pleomorphic lipoma 10.0
50 osteomalacia 10.0

Graphical network of the top 20 diseases related to Myositis Ossificans:



Diseases related to Myositis Ossificans

Symptoms & Phenotypes for Myositis Ossificans

MGI Mouse Phenotypes related to Myositis Ossificans:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.67 ACVR1 BMP1 COL1A1 FOS
2 mortality/aging MP:0010768 9.63 ACVR1 ACVR1C ASPA BMP1 COL1A1 FOS
3 hearing/vestibular/ear MP:0005377 9.62 ACVR1 ASPA COL1A1 FOS
4 limbs/digits/tail MP:0005371 9.56 ACVR1 BMP1 COL1A1 FOS
5 muscle MP:0005369 9.26 ACVR1 ASPA BMP1 COL1A1
6 skeleton MP:0005390 9.02 ACVR1 ASPA BMP1 COL1A1 FOS

Drugs & Therapeutics for Myositis Ossificans

Drugs for Myositis Ossificans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tretinoin Approved, Investigational, Nutraceutical Phase 3,Phase 2 302-79-4 444795 5538
2 Pharmaceutical Solutions Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Efficacy and Safety Study of Palovarotene for the Treatment of FOP Active, not recruiting NCT03312634 Phase 3 Palovarotene
2 An Efficacy and Safety Study of Palovarotene to Treat Preosseous Flare-ups in FOP Subjects Completed NCT02190747 Phase 2 Palovarotene;Placebo
3 An Open-Label Extension Study of Palovarotene Treatment in FOP Active, not recruiting NCT02279095 Phase 2 Palovarotene dose level 1;Palovarotene dose level 2;Palovarotene dose level 3;Palovarotene dose level 4
4 An Open-Label Extension Study of Palovarotene to Prevent Heterotopic Ossification in FOP Subjects in France Active, not recruiting NCT02979769 Phase 2 Palovarotene dose level 1;Palovarotene dose level 2
5 A Study to Examine the Safety, Tolerability and Effects on Abnormal Bone Formation of REGN2477 in Patients With Fibrodysplasia Ossificans Progressiva Active, not recruiting NCT03188666 Phase 2 REGN2477;Matching placebo
6 In-Home Evaluation of Episodic Administration of Palovarotene in Fibrodysplasia Ossificans Progressiva (FOP) Subjects Suspended NCT02521792 Phase 2 Palovarotene
7 Urine Sample Collection From FOP Patients Completed NCT02066324
8 The Fibrodysplasia Ossificans Progressiva (FOP) Connection Registry Recruiting NCT02745158
9 A Natural History Study of Fibrodysplasia Ossificans Progressiva (FOP) Active, not recruiting NCT02322255
10 Comparison Between CT and MRI in Preoperative Evaluation of Neurogenic Myositis Ossificans or Neurogenic Para-osteo-arthritis Not yet recruiting NCT03832556 Not Applicable

Search NIH Clinical Center for Myositis Ossificans

Genetic Tests for Myositis Ossificans

Anatomical Context for Myositis Ossificans

MalaCards organs/tissues related to Myositis Ossificans:

42
Bone, Bone Marrow, Spinal Cord, Lymph Node, Brain, Heart, Ovary

Publications for Myositis Ossificans

Articles related to Myositis Ossificans:

(show top 50) (show all 660)
# Title Authors Year
1
Myositis ossificans mimicking metaplastic breast cancer on core needle biopsy. ( 30641089 )
2019
2
Yoga-Induced Myositis Ossificans Traumatica of the Scapholunate Ligament. ( 30723608 )
2019
3
Two cases of myositis ossificans in children, after prolonged immobilization. ( 30839310 )
2019
4
Multifocal myositis ossificans in masticatory muscles 30 years after gunshot wound: case report and literature review. ( 27177980 )
2019
5
Myositis ossificans - Another condition with USP6 rearrangement, providing evidence of a relationship with nodular fasciitis and aneurysmal bone cyst. ( 29661729 )
2018
6
Myositis Ossificans in Sport: A Review. ( 30204632 )
2018
7
MRI Findings of Early Myositis Ossificans without Calcification or Ossification. ( 30255094 )
2018
8
Myositis ossificans traumatica of the masticatory muscles: etiology, diagnosis and treatment. ( 30373608 )
2018
9
Elbow Myositis Ossificans: Radiographic Evolution with Histologic Correlation. ( 30461430 )
2018
10
Idiopathic aggressive myositis ossificans of the hand infiltrating the flexor sheath/checkrein ligament, obliterating the common digital artery, and attenuating the digital nerve: A case report. ( 30567060 )
2018
11
Non-traumatic myositis ossificans as an uncommon cause of scoliosis: a case report and discussion of literature. ( 30576826 )
2018
12
Myositis Ossificans of the Masseter Muscle. ( 30787834 )
2018
13
Paratesticular myositis ossificans of the spermatic cord. ( 29301813 )
2018
14
Myositis Ossificans: Delayed Complication of Severe Muscle Contusion. ( 29712545 )
2018
15
Pseudomalignant myositis ossificans in the breast: A case report. ( 29844904 )
2018
16
Ankylosing Neurogenic Myositis Ossificans of the Hip: A Case Series and Review of Literature. ( 29896457 )
2018
17
COL1A1 is a fusionpartner of USP6 in myositis ossificans - FISH analysis of six cases. ( 29980413 )
2018
18
Myositis ossificans of a lumbrical muscle in a child's hand. ( 30045658 )
2018
19
Myositis Ossificans Traumatica of the Medial Pterygoid Muscle After Third Molar Tooth Extraction: A Case Report and Review of Literature. ( 30076806 )
2018
20
Imaging in myositis ossificans: Bone scintigraphy and 18F-fluorodeoxyglucose positron emission tomography/computed tomography. ( 28325501 )
2018
21
Myositis ossificans in children: a review. ( 28275867 )
2017
22
Heterotopic ossification (myositis ossificans progressiva): A condition interfering with rheumatic disease. ( 28293462 )
2017
23
Management of Myositis Ossificans of the Hand: A Case Report and a Review of the Literature. ( 28385291 )
2017
24
Myositis Ossificans of the Hip Due to Pyogenic Arthritis Caused by Campylobacter fetus Subspecies fetus. ( 28420848 )
2017
25
Extraskeletal osteosarcoma arising in myositis ossificans: a case report and review of the literature. ( 28536749 )
2017
26
Myositis ossificans in elbow mimicking soft tissue sarcoma: Similar clinical and radiological findings. ( 28641932 )
2017
27
Traumatic myositis ossificans circumscripta (MOC). ( 28679511 )
2017
28
A fatal case of metastatic squamous cell carcinoma in a patient with myositis ossificans traumatica. ( 28741585 )
2017
29
Surgical excision of symptomatic mature posttraumatic myositis ossificans: characteristics and outcomes in 32 athletes. ( 28780628 )
2017
30
Unsupervised Exercise-Induced Myositis Ossificans in the Brachialis Muscle of a Young Healthy Male: A Case Report. ( 28795074 )
2017
31
An Unusual Presentation of Myositis Ossificans in a Pediatric Patient. ( 26491916 )
2017
32
Myositis ossificans of the longus coli muscle following cervical spine fracture-dislocation. ( 27077572 )
2017
33
Adult Niemann-Pick disease type B with myositis ossificans: a case report. ( 26338042 )
2016
34
MR imaging and ultrasonography findings of early myositis ossificans: a case report. ( 27511030 )
2016
35
Synovial Sarcoma Mimicking Myositis Ossificans. ( 27595081 )
2016
36
Poster 92 Identifying Nonhereditary Myositis Ossificans Traumaticus in a Community Hospital. ( 27672859 )
2016
37
MYOSITIS OSSIFICANS TRAUMATICA IN A VAMPIRE BAT (DESMODUS ROTUNDUS). ( 27691970 )
2016
38
Pre-surgical CT-assessment of neurogenic myositis ossificans of the hip and risk factors of recurrence: a series of 101 consecutive patients. ( 27756329 )
2016
39
Myositis ossificans progressive: case report. ( 27800117 )
2016
40
Intra-abdominal myositis ossificans in an asymptomatic patient during closure of a Hartmann's colostomy. ( 27887014 )
2016
41
Delayed Sciatic Nerve Injury Resulting From Myositis Ossificans Traumatica. ( 26548968 )
2016
42
Myositis Ossificans of the Temporalis Muscle. ( 26703385 )
2016
43
Myositis ossificans of the platysma mimicking a malignancy: a case report with review of the literature. ( 26904497 )
2016
44
Myositis ossificans traumatica (circumscripta) and return to sport: A retrospective series of 19 cases. ( 26934992 )
2016
45
Myositis ossificans after navigated knee surgery: A report of two cases and literature review. ( 26993571 )
2016
46
18F-fluorodeoxyglucose-positron emission tomography avid paraspinal soft-tissue mass mimicking a malign neoplasm: non-traumatic myositis ossificans. ( 27001110 )
2016
47
Myositis ossificans of the masseter muscle: A rare location. Report of a case and review of literature. ( 27034763 )
2016
48
Posttraumatic myositis ossificans of the hand : A locally aggressive malignancy-mimicking tumor. ( 27048331 )
2016
49
A rare case of pediatric Nontraumatic Myositis Ossificans in the posterior triangle. ( 27063765 )
2016
50
Myositis Ossificans Associated with Prayer Mark. ( 27107753 )
2016

Variations for Myositis Ossificans

Expression for Myositis Ossificans

Search GEO for disease gene expression data for Myositis Ossificans.

Pathways for Myositis Ossificans

GO Terms for Myositis Ossificans

Cellular components related to Myositis Ossificans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 activin receptor complex GO:0048179 8.62 ACVR1 ACVR1C

Biological processes related to Myositis Ossificans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 9.4 BMP1 COL1A1
2 response to mechanical stimulus GO:0009612 9.37 COL1A1 FOS
3 pattern specification process GO:0007389 9.32 ACVR1 ACVR1C
4 response to cAMP GO:0051591 9.26 COL1A1 FOS
5 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.16 ACVR1 ACVR1C
6 activin receptor signaling pathway GO:0032924 8.96 ACVR1 ACVR1C
7 transforming growth factor beta receptor signaling pathway GO:0007179 8.8 ACVR1 ACVR1C FOS

Molecular functions related to Myositis Ossificans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SMAD binding GO:0046332 9.4 ACVR1 ACVR1C
2 growth factor binding GO:0019838 9.37 ACVR1 ACVR1C
3 transforming growth factor beta-activated receptor activity GO:0005024 9.32 ACVR1 ACVR1C
4 activin binding GO:0048185 9.26 ACVR1 ACVR1C
5 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.16 ACVR1 ACVR1C
6 transforming growth factor beta receptor activity, type I GO:0005025 8.96 ACVR1 ACVR1C
7 activin receptor activity, type I GO:0016361 8.62 ACVR1 ACVR1C

Sources for Myositis Ossificans

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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