MCID: MYS001
MIFTS: 43

Myositis Ossificans

Categories: Muscle diseases
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Aliases & Classifications for Myositis Ossificans

MalaCards integrated aliases for Myositis Ossificans:

Name: Myositis Ossificans 11 75 14 71
Ossification - Muscle 11
Myisitis Ossificans 11

Classifications:



External Ids:

Disease Ontology 11 DOID:668
MeSH 43 D009221
NCIt 49 C3253
SNOMED-CT 68 44551007
UMLS 71 C0027122

Summaries for Myositis Ossificans

Disease Ontology: 11 A myositis that is accompanied by ossification of muscle tissue or bony deposits in the muscles.

MalaCards based summary: Myositis Ossificans, also known as ossification - muscle, is related to fibrodysplasia ossificans progressiva and osseous heteroplasia, progressive. An important gene associated with Myositis Ossificans is USP6 (Ubiquitin Specific Peptidase 6), and among its related pathways/superpathways are ERK Signaling and DREAM Repression and Dynorphin Expression. The drugs Tin Fluorides and Antibodies, Monoclonal have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and lymph node, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia: 75 Myositis ossificans comprises two syndromes characterized by heterotopic ossification (calcification) of... more...

Related Diseases for Myositis Ossificans

Diseases related to Myositis Ossificans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 250)
# Related Disease Score Top Affiliating Genes
1 fibrodysplasia ossificans progressiva 33.1 FOS BMP4 BMP1 ACVR1
2 osseous heteroplasia, progressive 31.7 SPARC BMP4 BGLAP ACVR1
3 ankylosis 30.8 BMP4 BGLAP ACVR1
4 pseudosarcomatous fibromatosis 30.4 USP6 COL1A1 CALD1
5 fibroosseous pseudotumor of digits 30.3 USP6 COL1A1
6 parosteal osteosarcoma 29.9 SATB2 MDM2 CDK4
7 chondrosarcoma 29.9 SPARC MDM2 CDK4
8 cutaneous fibrous histiocytoma 29.9 COL1A1 CALD1
9 bone resorption disease 29.9 FOS COL1A1 BGLAP
10 osteogenic sarcoma 29.7 SPARC MDM2 FOS CDK4 BMP4 BMP1
11 connective tissue benign neoplasm 29.7 USP6 MDM2 CDK4 CALD1
12 connective tissue disease 29.7 MDM2 FOS COL1A1 CDK4 BGLAP
13 spindle cell lipoma 29.6 MDM2 CDK4 CALD1
14 lipomatosis, multiple 29.6 MDM2 CDK4 CALD1
15 scoliosis 29.1 SATB2 COL1A1 BMP4 BGLAP
16 extraosseous osteosarcoma 28.8 SPARC SATB2 MDM2 CDK4 CALD1 BGLAP
17 myositis 11.4
18 myopathy 11.2
19 sarcoma 10.6
20 tetanus 10.5
21 soft tissue sarcoma 10.5
22 short stature, onychodysplasia, facial dysmorphism, and hypotrichosis 10.4
23 osteomyelitis 10.4
24 bone cancer 10.4
25 polycystic liver disease 1 with or without kidney cysts 10.3
26 spondylitis 10.3
27 high bone mass osteogenesis imperfecta 10.3 COL1A1 BMP1
28 aneurysmal bone cysts 10.3
29 poliomyelitis 10.3
30 papillon-lefevre syndrome 10.2
31 sarcoma, synovial 10.2
32 congenital hemidysplasia with ichthyosiform erythroderma and limb defects 10.2
33 calcinosis 10.2
34 exostosis 10.2
35 fasciitis 10.2
36 children's interstitial lung disease 10.2
37 hemophilia 10.2
38 fibrogenesis imperfecta ossium 10.2 LEMD3 COL1A1
39 cardiomyopathy, familial restrictive, 3 10.2 BMP4 BMP1
40 telangiectatic osteogenic sarcoma 10.2 USP6 MDM2
41 spondyloarthropathy 1 10.2
42 osteoid osteoma 10.2
43 gastric cancer 10.2
44 cartilage disease 10.2
45 neuropathy 10.2
46 periostitis 10.2
47 piriformis syndrome 10.2
48 spinal cord injury 10.2
49 stickler syndrome, type i 10.2 COL1A1 BMP1
50 microphthalmia, syndromic 6 10.1 BMP4 ACVR1

Graphical network of the top 20 diseases related to Myositis Ossificans:



Diseases related to Myositis Ossificans

Symptoms & Phenotypes for Myositis Ossificans

MGI Mouse Phenotypes related to Myositis Ossificans:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.2 ACVR1 ANGPTL2 BGLAP BMP1 BMP4 CDK4
2 growth/size/body region MP:0005378 10.17 ACVR1 ANGPTL2 BMP1 BMP4 CALD1 CDK4
3 limbs/digits/tail MP:0005371 10.08 ACVR1 BMP1 BMP4 COL1A1 FOS MDM2
4 embryo MP:0005380 10.06 ACVR1 BMP1 BMP4 CDK4 COL1A1 FOS
5 muscle MP:0005369 10.04 ACVR1 BMP1 BMP4 CALD1 CDK4 COL1A1
6 neoplasm MP:0002006 9.99 ACVR1 CDK4 COL1A1 FOS MDM2 SPARC
7 craniofacial MP:0005382 9.97 ACVR1 BMP1 BMP4 CDK4 COL1A1 FOS
8 cellular MP:0005384 9.96 ACVR1 ANGPTL2 BGLAP BMP4 CDK4 COL1A1
9 digestive/alimentary MP:0005381 9.91 ACVR1 BMP1 BMP4 CDK4 COL1A1 MDM2
10 immune system MP:0005387 9.85 ACVR1 ANGPTL2 BGLAP BMP1 CDK4 COL1A1
11 skeleton MP:0005390 9.65 ACVR1 BGLAP BMP1 BMP4 CDK4 COL1A1
12 hematopoietic system MP:0005397 9.32 ANGPTL2 BGLAP BMP1 BMP4 CDK4 COL1A1

Drugs & Therapeutics for Myositis Ossificans

Drugs for Myositis Ossificans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Tin Fluorides Phase 3
2 Antibodies, Monoclonal Phase 3
3 Antibodies Phase 3
4 Pharmaceutical Solutions Phase 3
5 Immunoglobulins Phase 3
6
Isotretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4, 4759-48-2 5538 444795 5282379
7
Saracatinib Investigational Phase 2 379231-04-6 10302451
8
Midazolam Approved, Illicit Phase 1 59467-70-8 4192
9 GABA Modulators Phase 1
10 Anesthetics, Intravenous Phase 1
11 Anesthetics, General Phase 1
12 Anesthetics Phase 1
13 Psychotropic Drugs Phase 1
14 Hypnotics and Sedatives Phase 1
15 Anti-Anxiety Agents Phase 1
16 Neurotransmitter Agents Phase 1

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Rollover Study; Multicentre, Phase III, Open-label Study to Further Evaluate the Safety and Efficacy of Palovarotene Capsules in Male and Female Participants Aged ≥14 Years With Fibrodysplasia Ossificans Progressiva (FOP) Who Have Completed Study PVO-1A-301 or PVO-1A-202/PVO-1A-204 and May Benefit From Palovarotene Therapy. Recruiting NCT05027802 Phase 3 Palovarotene
2 A Phase 3, Efficacy and Safety Study of Oral Palovarotene for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP) Active, not recruiting NCT03312634 Phase 3 Palovarotene
3 Phase 3 Randomized, Placebo-Controlled Study to Assess Safety, Tolerability, and Efficacy of Garetosmab in Patients With Fibrodysplasia Ossificans Progressiva Not yet recruiting NCT05394116 Phase 3 Garetosmab;Placebo
4 Evaluation of Efficacy and Safety of Garetosmab in Japanese Adult Patients With Fibrodysplasia Ossificans Progressiva Withdrawn NCT04577820 Phase 3 garetosmab
5 A Phase 2, Open-Label Extension, Efficacy and Safety Study of a Retinoic Acid Receptor Gamma (RARγ)-Specific Agonist (Palovarotene) in the Treatment of Preosseous Flare-ups in Subjects With Fibrodysplasia Ossificans Progressiva (FOP) Completed NCT02979769 Phase 2 Palovarotene
6 A Phase 2 Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of a RARγ-Specific Agonist (Palovarotene) in the Treatment of Preosseous Flare-ups in Subjects With Fibrodysplasia Ossificans Progressiva (FOP) Completed NCT02190747 Phase 2 Palovarotene;Placebo
7 A Phase 2, Open-Label Extension, Efficacy and Safety Study of a Retinoic Acid Receptor Gamma (RARγ) Specific Agonist (Palovarotene) in the Treatment of Preosseous Flare-ups in Subjects With Fibrodysplasia Ossificans Progressiva (FOP) Completed NCT02279095 Phase 2 Palovarotene dose level 1;Palovarotene dose level 2;Palovarotene dose level 3;Palovarotene dose level 4
8 A Randomized, Placebo-controlled Study to Assess the Safety, Tolerability, Pharmacokinetics, and Effects on Heterotopic Bone Formation of REGN2477 in Patients With Fibrodysplasia Ossificans Progressiva Completed NCT03188666 Phase 2 REGN2477;Matching placebo
9 A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of INCB000928 in Participants With Fibrodysplasia Ossificans Progressiva Recruiting NCT05090891 Phase 2 INCB000928;placebo
10 A Phase 2, Two-part, Placebo-controlled, Parallel-group, Double-blind Study to Assess the Efficacy and Safety of 2 Dosage Regimens of Oral IPN60130 for the Treatment of Fibrodysplasia Ossificans Progressiva in Male and Female Participants 5 Years of Age and Older. Recruiting NCT05039515 Phase 2 IPN60130;Placebo
11 Saracatinib Trial TO Prevent FOP Recruiting NCT04307953 Phase 2 AZD0530 Difumarate;Matching placebo
12 A Phase 2, In-Home, Safety and Efficacy Evaluation of Episodic Administration of Open-Label Palovarotene in Subjects With Fibrodysplasia Ossificans Progressiva (FOP) Terminated NCT02521792 Phase 2 Palovarotene
13 Single-Ascending Dose Phase 1 Study to Assess the Safety, Tolerability, and Pharmacokinetics of DS-6016a After Subcutaneous Injection in Healthy Japanese Subjects Completed NCT04818398 Phase 1 DS-6016a;Placebo
14 An Open-Label Study Evaluating the Effect of Food on the Pharmacokinetics of Palovarotene and the Effect of Palovarotene on the Pharmacokinetics of the CYP3A4 Substrate Midazolam in Two Cohorts of Healthy Adult Subjects Completed NCT04829773 Phase 1 Palovarotene;midazolam
15 An International Cross-sectional Survey to Evaluate the Burden of Fibrodysplasia Ossificans Progressiva (FOP) on Patients and Their Families. Completed NCT04665323
16 Urine Sample Collection From Patients With Fibrodysplasia Ossificans Progressiva (FOP) for Biomarker Analysis Completed NCT02066324
17 A Natural History, Non-Interventional, Two-Part Study in Subjects With Fibrodysplasia Ossificans Progressiva (FOP) Completed NCT02322255
18 Preoperative Evaluation of Neurogenic Myositis Ossificans or Neurogenic Para-osteo-arthritis: Comparison Between Computed Tomography and Magnetic Resonance Imaging in Preoperative Evaluation Recruiting NCT03832556
19 FOP Connection: A Global Registry for the Fibrodysplasia Ossificans Progressiva Community Recruiting NCT02745158

Search NIH Clinical Center for Myositis Ossificans

Genetic Tests for Myositis Ossificans

Anatomical Context for Myositis Ossificans

Organs/tissues related to Myositis Ossificans:

MalaCards : Bone, Spinal Cord, Lymph Node, Skeletal Muscle, Bone Marrow, Breast, Brain

Publications for Myositis Ossificans

Articles related to Myositis Ossificans:

(show top 50) (show all 1480)
# Title Authors PMID Year
1
Aggressive atraumatic myositis ossificans in a toddler. 62
36193266 2022
2
Pin-Related Complications in Computer Navigated and Robotic-Assisted Knee Arthroplasty: A Systematic Review. 62
35537611 2022
3
Extra-skeletal osteosarcoma: a review. 62
36194245 2022
4
Histopathogenesis of bone- and soft-tissue tumor spectrum with USP6 gene rearrangement: multiple partners involved in the tissue repair process. 62
36205240 2022
5
Clinical characteristics of 10 Chinese patients with melorheostosis and identification of a somatic MAP2K1 variant in one case. 62
36004822 2022
6
Multimodality imaging features of USP6-associated neoplasms. 62
35962835 2022
7
Calcific Myonecrosis: Solving the Diagnostic Dilemma. 62
35928654 2022
8
Myositis Ossificans Presenting as a Rapidly Enlarging Neck Mass With Dyspnea. 62
36171807 2022
9
Non-traumatic myositis ossificans circumscripta in the anterior abdominal wall of a seven-year-old Ugandan child: A case report. 62
35898744 2022
10
Intense 68Ga-FAPI Uptake in a Patient With Myositis Ossificans: Mimicking Bone Malignancy. 62
35426847 2022
11
Myositis ossificans of the breast - A rare case report with radiologic-pathologic correlation. 62
35432665 2022
12
Fibrodysplasia (myositis) ossificans progressiva (FOP). 62
35348929 2022
13
Myositis Ossificans: A Rare Etiology of Sciatica. 62
32101909 2022
14
Melorheostosis or "Dripping Candle Wax" Bone Disease. 62
35705240 2022
15
The role of acetic acid in orthopaedic surgery. 62
34310234 2022
16
Zygomaticocoronoid ankylosis with possible myositis ossificans: a very rare case. 62
34608578 2022
17
Giant nontraumatic myositis ossificans in a child: A case report. 62
35434084 2022
18
Management of anterior thigh injuries in soccer players: practical guide. 62
35303927 2022
19
Common Soft Tissue Mass-like Lesions that Mimic Malignancy. 62
35236595 2022
20
Myositis ossificans: a rare neonatal presentation. 62
34601621 2022
21
Comparative evaluation of pinning and cast fixation vs. external fixation after lateral closing-wedge osteotomy for cubitus varus in children. 62
34052443 2022
22
[Progressive myositis ossificans: Case report]. 62
35274918 2022
23
Monitoring and Management of Fibrodysplasia Ossificans Progressiva: Current Perspectives. 62
35480068 2022
24
Case Report: Unable to Jump Like a Kangaroo Due to Myositis Ossificans Circumscripta. 62
35865877 2022
25
Bone chip versus myositis ossificans after supracondylar fracture of humerus. 62
35721631 2022
26
Intramuscular ossifying metastasis from oesophageal carcinoma, with a pattern distinct from myositis ossificans - A case report. 62
34926153 2022
27
Non-traumatic Myositis Ossificans as Unusual Cause of Neck Pain During COVID-19 Pandemic: a Case Report. 62
35434525 2022
28
Inverted horn myositis ossificans circumscripta in the pelvis and bilateral adductors: an unreported shape at an unusual site. 62
35076134 2022
29
Subungual Exostosis on the Right Hallux. 62
35294159 2021
30
Bone Scanning Findings in a Patient with Heat Stroke-Induced Rhabdomyolysis. 62
34330808 2021
31
Are open surgery and total resection good choices for traumatic myositis ossificans in children? 62
34559305 2021
32
Myositis ossificans following COVID-19 vaccination. 62
34109386 2021
33
Expert Consensus on the Contraindications and Cautions of Foam Rolling-An International Delphi Study. 62
34830642 2021
34
Bilateral Post Traumatic Myositis Ossificans of Adductor Longus in a Young Soccer Player: A Case Report and Literature Review. 62
34752431 2021
35
Surgical Management of Extensor Digitorum Brevis Manus Anomaly with a Dorsal Ganglion Cyst. 62
34631297 2021
36
Myositis Ossificans Traumatica, an Unusual Cause of Mandibular Hypomobility. 62
33534317 2021
37
Non-traumatic myositis ossificans of the Right masseter muscle: a case report and review of the literature. 62
34429994 2021
38
Efficacy of ultra-early rehabilitation on elbow function after Slongo's external fixation for supracondylar humeral fractures in older children and adolescents. 62
34419104 2021
39
Post-traumatic myositis ossificans: a benign lesion that simulates malignant bone and soft tissue tumours. 62
34377549 2021
40
Myositis ossificans of the hip joint causing sciatic nerve palsy following Guillain-barré syndrome: A case report. 62
34171613 2021
41
Neglected posterior dislocation of elbow: A review. 62
33996454 2021
42
Novel partners of USP6 gene in a spectrum of bone and soft tissue lesions. 62
33558945 2021
43
Myositis ossificans revisited - The largest reported case series. 62
33816108 2021
44
Solitary Bone Cyst Like Areas in Myositis Ossificans: A Breast Mass in a Child. 62
31757181 2021
45
Clinical Results of Acetabular Fracture via the Pararectus versus Ilioinguinal Approach. 62
33945221 2021
46
Pelvic MRI in spinal cord injury patients: incidence of muscle signal change and early heterotopic ossification. 62
32873893 2021
47
A nontraumatic myositis ossificans case of the forearm: Case report and literature review. 62
33815604 2021
48
Bilateral irreducible asymmetrical fracture-dislocation of the hip: A case report and literature review. 62
33774447 2021
49
Unusual Presentation of Widely Metastatic Extraskeletal Osteosarcoma: Case Report. 62
34276871 2021
50
Nontraumatic Myositis Ossificans in the Thoracolumbar Paravertebral Muscle. 62
32040057 2021

Variations for Myositis Ossificans

Expression for Myositis Ossificans

Search GEO for disease gene expression data for Myositis Ossificans.

Pathways for Myositis Ossificans

Pathways related to Myositis Ossificans according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.53 MDM2 FOS COL1A1 CDK4 BMP4 BMP1
2
Show member pathways
12.5 FOS CDK4 BMP4 ACVR1
3
Show member pathways
12.44 SPARC COL1A1 BMP4 BMP1
4 11.98 SPARC BMP4 ACVR1
5
Show member pathways
11.94 MDM2 FOS CDK4
6 11.65 SPARC MDM2 COL1A1
7 11.59 BGLAP BMP4 SPARC
8 11.47 MDM2 FOS BGLAP
9
Show member pathways
11.45 MDM2 FOS CDK4 BMP4 ACVR1
10
Show member pathways
11.33 SATB2 COL1A1 BGLAP
11 11.25 MDM2 CDK4 BGLAP
12 11.19 MDM2 FOS BMP4 BMP1
13 11.09 FOS COL1A1 BGLAP
14 10.72 FOS COL1A1 BGLAP
15 10.71 SPARC COL1A1

GO Terms for Myositis Ossificans

Biological processes related to Myositis Ossificans according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 response to xenobiotic stimulus GO:0009410 10.17 FOS COL1A1 CDK4 BGLAP
2 response to insulin GO:0032868 10.02 FOS COL1A1 BGLAP
3 atrioventricular valve morphogenesis GO:0003181 9.86 MDM2 ACVR1
4 cellular response to growth factor stimulus GO:0071363 9.85 ACVR1 BGLAP BMP4
5 anatomical structure development GO:0048856 9.84 BMP4 COL1A1 SPARC
6 cellular response to zinc ion starvation GO:0034224 9.83 FOS BGLAP
7 cartilage development GO:0051216 9.81 SATB2 BMP4 BMP1
8 cellular response to phorbol 13-acetate 12-myristate GO:1904628 9.8 FOS CDK4
9 negative regulation of activin receptor signaling pathway GO:0032926 9.78 LEMD3 ACVR1
10 response to mechanical stimulus GO:0009612 9.77 FOS COL1A1 BGLAP
11 response to organic cyclic compound GO:0014070 9.75 FOS COL1A1 BGLAP
12 response to gravity GO:0009629 9.73 FOS BGLAP
13 protein localization to nucleus GO:0034504 9.73 BMP4 COL1A1 MDM2
14 blood vessel development GO:0001568 9.72 MDM2 COL1A1 BMP4
15 BMP signaling pathway involved in heart development GO:0061312 9.71 BMP4 ACVR1
16 regulation of gene expression GO:0010468 9.63 SATB2 MDM2 FOS CDK4 BMP4
17 skeletal system development GO:0001501 9.5 COL1A1 BMP4 BMP1 BGLAP
18 ossification GO:0001503 9.1 COL1A1 BMP4 BMP1 BGLAP

Sources for Myositis Ossificans

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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