MCID: MYS001
MIFTS: 41

Myositis Ossificans

Categories: Muscle diseases

Aliases & Classifications for Myositis Ossificans

MalaCards integrated aliases for Myositis Ossificans:

Name: Myositis Ossificans 12 74 15 71
Ossification - Muscle 12
Myisitis Ossificans 12

Classifications:



External Ids:

Disease Ontology 12 DOID:668
MeSH 43 D009221
NCIt 49 C3253
SNOMED-CT 67 44551007
UMLS 71 C0027122

Summaries for Myositis Ossificans

Disease Ontology : 12 A myositis that is accompanied by ossification of muscle tissue or bony deposits in the muscles.

MalaCards based summary : Myositis Ossificans, also known as ossification - muscle, is related to fibrodysplasia ossificans progressiva and osseous heteroplasia, progressive. An important gene associated with Myositis Ossificans is ACVR1 (Activin A Receptor Type 1), and among its related pathways/superpathways are ERK Signaling and Degradation of the extracellular matrix. The drugs Tretinoin and Saracatinib have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and spinal cord, and related phenotypes are cellular and craniofacial

Wikipedia : 74 Myositis ossificans comprises two syndromes characterized by heterotopic ossification (calcification) of... more...

Related Diseases for Myositis Ossificans

Diseases related to Myositis Ossificans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 197)
# Related Disease Score Top Affiliating Genes
1 fibrodysplasia ossificans progressiva 33.9 FOS BMP4 BMP1 ACVR1
2 osseous heteroplasia, progressive 32.0 SPARC BMP4 BGLAP ACVR1
3 fibroosseous pseudotumor of digits 30.6 USP6 COL1A1
4 ankylosis 30.4 SP7 BMP4 BGLAP ACVR1
5 pleomorphic lipoma 30.2 MDM2 CDK4
6 spindle cell lipoma 30.1 MDM2 CDK4
7 chondrosarcoma 30.1 SPARC MDM2 CDK4
8 juxtacortical osteosarcoma 29.9 SATB2 MDM2 CDK4
9 bone resorption disease 29.5 SP7 FOS COL1A1 BGLAP
10 extraosseous osteosarcoma 29.4 SPARC SP7 MDM2 CDK4 BGLAP
11 osteogenic sarcoma 29.4 SPARC SP7 MDM2 FOS CDK4 BMP1
12 myopathy 11.8
13 myositis 11.5
14 tetanus 10.6
15 sarcoma 10.5
16 spindle cell sarcoma 10.5
17 soft tissue sarcoma 10.5
18 osteomyelitis 10.4
19 high bone mass osteogenesis imperfecta 10.4 COL1A1 BMP1
20 inflammatory spondylopathy 10.4
21 spondylitis 10.4
22 aneurysmal bone cysts 10.3
23 poliomyelitis 10.3
24 telangiectatic osteogenic sarcoma 10.3 USP6 MDM2
25 synovial chondromatosis 10.3 COL1A1 BMP4
26 brachydactyly, type a1, b 10.3 BMP4 ACVR1
27 calcinosis 10.3
28 pseudosarcomatous fibromatosis 10.3
29 fasciitis 10.3
30 hemophilia 10.3
31 head injury 10.3
32 spondyloarthropathy 1 10.2
33 osteoid osteoma 10.2
34 sarcoma, synovial 10.2
35 periostitis 10.2
36 spinal cord injury 10.2
37 ring chromosome 7 10.2 MDM2 CDK4
38 mediastinum liposarcoma 10.2 MDM2 CDK4
39 hereditary melanoma 10.2 MDM2 CDK4
40 undifferentiated embryonal sarcoma of the liver 10.2 MDM2 CDK4
41 embryonal sarcoma 10.2 MDM2 CDK4
42 spindle cell liposarcoma 10.2 MDM2 CDK4
43 pediatric liposarcoma 10.2 MDM2 CDK4
44 infiltrating lipoma 10.2 MDM2 CDK4
45 gastric liposarcoma 10.2 MDM2 CDK4
46 lipoblastoma 10.2 MDM2 CDK4
47 diffuse lipomatosis 10.2 MDM2 CDK4
48 liposarcoma of bone 10.2 MDM2 CDK4
49 malignant inflammatory fibrous histiocytoma 10.2 MDM2 CDK4
50 adult liposarcoma 10.2 MDM2 CDK4

Graphical network of the top 20 diseases related to Myositis Ossificans:



Diseases related to Myositis Ossificans

Symptoms & Phenotypes for Myositis Ossificans

MGI Mouse Phenotypes related to Myositis Ossificans:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.15 ACVR1 BGLAP BMP4 CDK4 COL1A1 FOS
2 craniofacial MP:0005382 10.13 ACVR1 BMP1 BMP4 CDK4 COL1A1 FOS
3 homeostasis/metabolism MP:0005376 10.11 ACVR1 BGLAP BMP1 BMP4 CDK4 COL1A1
4 hematopoietic system MP:0005397 10.1 BGLAP BMP1 BMP4 CDK4 COL1A1 FOS
5 immune system MP:0005387 10.06 ACVR1 BGLAP BMP1 CDK4 COL1A1 FOS
6 embryo MP:0005380 10.03 ACVR1 BMP1 BMP4 CDK4 COL1A1 FOS
7 digestive/alimentary MP:0005381 10 ACVR1 BMP1 BMP4 CDK4 COL1A1 MDM2
8 limbs/digits/tail MP:0005371 9.91 ACVR1 BMP1 BMP4 COL1A1 FOS MDM2
9 muscle MP:0005369 9.63 ACVR1 BMP1 BMP4 CDK4 COL1A1 MDM2
10 neoplasm MP:0002006 9.43 ACVR1 CDK4 COL1A1 FOS MDM2 SPARC
11 skeleton MP:0005390 9.36 ACVR1 BGLAP BMP1 BMP4 CDK4 COL1A1

Drugs & Therapeutics for Myositis Ossificans

Drugs for Myositis Ossificans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 444795 5538
2
Saracatinib Investigational Phase 2 379231-04-6

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 A Phase 3, Efficacy and Safety Study of Oral Palovarotene for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP) Active, not recruiting NCT03312634 Phase 3 Palovarotene
2 A Phase 2 Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of a RARγ-Specific Agonist (Palovarotene) in the Treatment of Preosseous Flare-ups in Subjects With Fibrodysplasia Ossificans Progressiva (FOP) Completed NCT02190747 Phase 2 Palovarotene;Placebo
3 Saracatinib Trial TO Prevent FOP Recruiting NCT04307953 Phase 2 AZD0530 Difumarate;Matching placebo
4 A Phase 2, Open-Label Extension, Efficacy and Safety Study of a RARγ Specific Agonist (Palovarotene) in the Treatment of Preosseous Flare-ups in Subjects With Fibrodysplasia Ossificans Progressiva (FOP) Active, not recruiting NCT02279095 Phase 2 Palovarotene dose level 1;Palovarotene dose level 2;Palovarotene dose level 3;Palovarotene dose level 4
5 A Phase 2, Open-Label Extension, Efficacy and Safety Study of a RARγ-Specific Agonist (Palovarotene) in the Treatment of Preosseous Flare-ups in Subjects With Fibrodysplasia Ossificans Progressiva (FOP) Active, not recruiting NCT02979769 Phase 2 Palovarotene dose level 1;Palovarotene dose level 2
6 A Randomized, Placebo-controlled Study to Assess the Safety, Tolerability, Pharmacokinetics, and Effects on Heterotopic Bone Formation of REGN2477 in Patients With Fibrodysplasia Ossificans Progressiva Active, not recruiting NCT03188666 Phase 2 REGN2477;Matching placebo
7 A Phase 2, In-Home, Safety and Efficacy Evaluation of Episodic Administration of Open-Label Palovarotene in Subjects With Fibrodysplasia Ossificans Progressiva (FOP) Terminated NCT02521792 Phase 2 Palovarotene
8 Urine Sample Collection From Patients With Fibrodysplasia Ossificans Progressiva (FOP) for Biomarker Analysis Completed NCT02066324
9 A Natural History, Non-Interventional, Two-Part Study in Subjects With Fibrodysplasia Ossificans Progressiva (FOP) Completed NCT02322255
10 Preoperative Evaluation of Neurogenic Myositis Ossificans or Neurogenic Para-osteo-arthritis: Comparison Between Computed Tomography and Magnetic Resonance Imaging in Preoperative Evaluation Recruiting NCT03832556
11 FOP Connection: A Global Registry for the Fibrodysplasia Ossificans Progressiva Community Recruiting NCT02745158

Search NIH Clinical Center for Myositis Ossificans

Genetic Tests for Myositis Ossificans

Anatomical Context for Myositis Ossificans

MalaCards organs/tissues related to Myositis Ossificans:

40
Bone, Brain, Spinal Cord, Breast, Lymph Node, Skeletal Muscle, Bone Marrow

Publications for Myositis Ossificans

Articles related to Myositis Ossificans:

(show top 50) (show all 1391)
# Title Authors PMID Year
1
Diagnostic utility of perilesional muscle edema in myositis ossificans. 61
31907558 2020
2
Prevalence of soft tissue calcifications in the head and neck region: A cone-beam computed tomography study. 61
32525108 2020
3
Knee intra-articular extraskeletal aneurysmal bone cyst: a case report and review of literature. 61
32435899 2020
4
A bump in the neck. Myositis ossificans of the omohyoid muscle: Imaging findings. 61
32323703 2020
5
Myositis ossificans of the masticatory muscle monitored over three generations: A case report and review of the literature. 61
32256742 2020
6
Myositis ossificans-like soft tissue aneurysmal bone cyst: a clinical, radiological, and pathological study of seven cases with COL1A1-USP6 fusion and a novel ANGPTL2-USP6 fusion. 61
32157177 2020
7
Surgical excision of post-traumatic myositis ossificans of the adductor longus in a football player. 61
32132101 2020
8
Nontraumatic Myositis Ossificans in the Thoracolumbar Paravertebral Muscle. 61
32040057 2020
9
Myositis Ossificans: A Rare Etiology of Sciatica. 61
32101909 2020
10
Battle Against Musculoskeletal Tumors: Descriptive Data of Military Hospital Experience. 61
32269986 2020
11
Myositis ossificans of mobile wad of Henry-Tennis elbow mimic. 61
32476757 2020
12
Giant cell tumour-like features of myositis ossificans in cytology-a case report. 61
31991033 2020
13
Idiopathic myositis ossificans of the deltoid muscle: A case report with unique presentation and MRI findings. 61
32163906 2020
14
What is new about the molecular genetics in matrix-producing soft tissue tumors? -The contributions to pathogenetic understanding and diagnostic classification. 61
31701222 2020
15
Late onset hyperplastic callus formation in osteogenesis imperfecta type V simulating osteosarcoma-A case report. 61
32305663 2020
16
Myositis ossificans traumatica of the piriformis muscle: a rare mature case in an adult African male. 61
31586233 2019
17
Myositis ossificans in the diabetic foot: a review of the literature with an illustrative case series. 61
31839972 2019
18
Calcified or ossified benign soft tissue lesions that may simulate malignancy. 61
31297550 2019
19
Myositis ossificans mimicking metaplastic breast cancer on core needle biopsy. 61
30641089 2019
20
Solitary Bone Cyst Like Areas in Myositis Ossificans: A Breast Mass in a Child. 61
31757181 2019
21
Myositis ossificans in the infraspinatus muscle: The key to diagnosis. 61
31788296 2019
22
Surgical management of Gartland type III supracondylar humerus fractures in older children: a retrospective study. 61
31568219 2019
23
Myositis Ossificans Traumatica of the Temporal Muscle: a Case Report and Literature Review Emphasizing Radiographic Features on Computed Tomography and Magnetic Resonance Imaging. 61
32158529 2019
24
Pseudomalignant Myositis Ossificans of the Neck in a Child: Case Report and Review of the Literature. 61
31260851 2019
25
Myositis ossificans in elbow mimicking soft tissue sarcoma: Similar clinical and radiological findings. 61
28641932 2019
26
Bilateral overuse myositis ossificans of the triceps: report of an unusual case. 61
32011986 2019
27
Elbow Myositis Ossificans: Radiographic Evolution With Histologic Correlation. 61
30461430 2019
28
[Myositis ossificans located at the chest wall]. 61
31373459 2019
29
Soft tissue aneurysmal bone cyst: six new cases with imaging details, molecular pathology, and review of the literature. 61
30603771 2019
30
Fibro-osseous pseudotumor of digits and myositis ossificans show consistent COL1A1-USP6 rearrangement: a clinicopathological and genetic study of 27 cases. 61
30946936 2019
31
Expression Profiling of Receptor-Activator of Nuclear Factor-Kappa B Ligand in Soft Tissue Tumors. 61
31189751 2019
32
Feasibility of bisphosphonate therapy in an Indian pediatric patient of fibrodysplasia ossificans progressiva. 61
31041177 2019
33
Calcified leiomyoma of the deltoid: pathophysiology and imaging review. 61
30187111 2019
34
Time after time: individuals with multiple fractures and injury recidivists in long eighteenth-century (c. 1666-1837) London. 61
30245230 2019
35
[Fibrodysplasia ossificans progressiva. Report of one case]. 61
31344178 2019
36
Two cases of myositis ossificans in children, after prolonged immobilization. 61
30839310 2019
37
Non-traumatic myositis ossificans of the thigh. A case report. 61
31112518 2019
38
Focal Myositis of the Leg Presenting as Fever of Unknown Origin Detected by FDG PET/CT. 61
30562199 2019
39
Nontraumatic Myositis Ossificans as an Uncommon Cause of Scoliosis: Case Report and Review of the Literature. 61
30576826 2019
40
Multifocal myositis ossificans in masticatory muscles 30 years after gunshot wound: case report and literature review. 61
27177980 2019
41
Yoga-Induced Myositis Ossificans Traumatica of the Scapholunate Ligament. 61
30723608 2019
42
Fatal atlantoaxial dislocation due to an odontoid synchondrosis fracture in a child with chromosome 9 abnormality: A case report. 61
30528850 2019
43
Musculoskeletal "don't touch" lesions: pictorial essay. 61
30804616 2019
44
High resolution ultrasound for imaging complications of muscle injury: Is there an additional role for elastography? 61
31355586 2019
45
Fibro-osseous pseudotumor on the hyponychium of the great toe. 61
30710901 2019
46
Complete Extra-articular Ankylosis of Hip and Stiff Elbow in a Case of Extensive Myositis Ossificans: A Rare Presentation. 61
32547984 2019
47
Surgical management of Gartland type III supracondylar humerus fractures in older children: a retrospectively study. 61
30614961 2019
48
Myositis ossificans of a lumbrical muscle in a child's hand. 61
30045658 2018
49
Myositis Ossificans Traumatica of the Medial Pterygoid Muscle After Third Molar Tooth Extraction: A Case Report and Review of Literature. 61
30076806 2018
50
COL1A1 is a fusionpartner of USP6 in myositis ossificans - FISH analysis of six cases. 61
29980413 2018

Variations for Myositis Ossificans

Expression for Myositis Ossificans

Search GEO for disease gene expression data for Myositis Ossificans.

Pathways for Myositis Ossificans

Pathways related to Myositis Ossificans according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.51 MDM2 FOS COL1A1 CDK4 BMP4 BMP1
2
Show member pathways
12.43 SPARC COL1A1 BMP4 BMP1
3
Show member pathways
12.33 FOS CDK4 BMP4 ACVR1
4 11.78 FOS BMP4 ACVR1
5 11.57 SPARC MDM2 COL1A1
6 11.41 MDM2 FOS BGLAP
7 11.29 MDM2 FOS BMP4 BMP1
8 10.99 FOS COL1A1 BGLAP
9 10.9 SPARC SP7 BMP4 BGLAP
10 10.72 FOS COL1A1 BGLAP
11 10.55 COL1A1 BGLAP

GO Terms for Myositis Ossificans

Biological processes related to Myositis Ossificans according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.84 SPARC MDM2 BMP4 ACVR1
2 regulation of gene expression GO:0010468 9.77 SATB2 MDM2 FOS CDK4 BMP4
3 response to toxic substance GO:0009636 9.73 MDM2 FOS CDK4
4 skeletal system development GO:0001501 9.73 COL1A1 BMP4 BMP1 BGLAP
5 cartilage development GO:0051216 9.72 SATB2 BMP4 BMP1
6 response to drug GO:0042493 9.72 MDM2 FOS COL1A1 CDK4 BGLAP
7 response to mechanical stimulus GO:0009612 9.7 FOS COL1A1 BGLAP
8 blood vessel development GO:0001568 9.69 MDM2 COL1A1 BMP4
9 bone development GO:0060348 9.67 SPARC BMP4 BGLAP
10 response to cAMP GO:0051591 9.63 SPARC FOS COL1A1
11 outflow tract septum morphogenesis GO:0003148 9.62 BMP4 ACVR1
12 negative regulation of cell cycle arrest GO:0071157 9.62 MDM2 CDK4
13 response to lead ion GO:0010288 9.61 SPARC CDK4
14 osteoblast development GO:0002076 9.61 SATB2 BGLAP
15 endocardial cushion morphogenesis GO:0003203 9.6 MDM2 ACVR1
16 positive regulation of cartilage development GO:0061036 9.59 BMP4 BMP1
17 response to hyperoxia GO:0055093 9.58 COL1A1 CDK4
18 smooth muscle cell differentiation GO:0051145 9.58 BMP4 ACVR1
19 protein localization to nucleus GO:0034504 9.58 MDM2 COL1A1 BMP4
20 atrioventricular valve morphogenesis GO:0003181 9.57 MDM2 ACVR1
21 osteoblast differentiation GO:0001649 9.56 SP7 COL1A1 BMP4 BGLAP
22 BMP signaling pathway involved in heart development GO:0061312 9.48 BMP4 ACVR1
23 ossification GO:0001503 9.35 SPARC COL1A1 BMP4 BMP1 BGLAP
24 response to gravity GO:0009629 9.33 SPARC FOS BGLAP
25 cellular response to growth factor stimulus GO:0071363 9.02 SPARC MDM2 BMP4 BGLAP ACVR1

Sources for Myositis Ossificans

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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