MCID: MYS001
MIFTS: 38

Myositis Ossificans

Categories: Muscle diseases

Aliases & Classifications for Myositis Ossificans

MalaCards integrated aliases for Myositis Ossificans:

Name: Myositis Ossificans 12 75 15 72
Ossification - Muscle 12
Myisitis Ossificans 12

Classifications:



External Ids:

Disease Ontology 12 DOID:668
MeSH 44 D009221
NCIt 50 C3253
SNOMED-CT 68 44551007
UMLS 72 C0027122

Summaries for Myositis Ossificans

Disease Ontology : 12 A myositis that is accompanied by ossification of muscle tissue or bony deposits in the muscles.

MalaCards based summary : Myositis Ossificans, also known as ossification - muscle, is related to fibrodysplasia ossificans progressiva and myopathy. An important gene associated with Myositis Ossificans is USP6 (Ubiquitin Specific Peptidase 6), and among its related pathways/superpathways are TGF-beta signaling pathway (KEGG) and Transcription_Role of VDR in regulation of genes involved in osteoporosis. The drugs Tretinoin and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and spinal cord, and related phenotypes are craniofacial and limbs/digits/tail

Wikipedia : 75 Myositis ossificans comprises two syndromes characterized by heterotopic ossification (calcification) of... more...

Related Diseases for Myositis Ossificans

Diseases related to Myositis Ossificans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
# Related Disease Score Top Affiliating Genes
1 fibrodysplasia ossificans progressiva 33.1 FOS BMP1 ACVR1
2 myopathy 11.8
3 osseous heteroplasia, progressive 11.5
4 myositis 11.5
5 osteogenic sarcoma 10.8
6 tetanus 10.6
7 ankylosis 10.5
8 sarcoma 10.5
9 spindle cell sarcoma 10.5
10 soft tissue sarcoma 10.5
11 osteomyelitis 10.4
12 inflammatory spondylopathy 10.4
13 extraosseous osteosarcoma 10.4
14 spondylitis 10.4
15 chondrosarcoma 10.3
16 juxtacortical osteosarcoma 10.3
17 poliomyelitis 10.3
18 aneurysmal bone cysts 10.3
19 calcinosis 10.3
20 pseudosarcomatous fibromatosis 10.3
21 fasciitis 10.3
22 hemophilia 10.3
23 spinal cord injury 10.3
24 spondyloarthropathy 1 10.2
25 osteoid osteoma 10.2
26 pulmonary alveolar microlithiasis 10.2
27 sarcoma, synovial 10.2
28 periostitis 10.2
29 head injury 10.2
30 cherubism 10.1
31 branchiootic syndrome 1 10.1
32 alkuraya-kucinskas syndrome 10.1
33 dermatomyositis 10.1
34 mumps 10.1
35 hemiplegia 10.1
36 cerebral palsy 10.1
37 exostosis 10.1
38 ischemia 10.1
39 paraplegia 10.1
40 compartment syndrome 10.1
41 47,xyy 10.1
42 fibromatosis 10.1
43 bunion 10.1
44 congenital amyoplasia 10.1
45 progressive familial heart block, type ia 10.0
46 burkitt lymphoma 10.0
47 breast cancer 10.0
48 colorectal cancer 10.0
49 lipomatosis, multiple 10.0
50 radioulnar synostosis 10.0

Graphical network of the top 20 diseases related to Myositis Ossificans:



Diseases related to Myositis Ossificans

Symptoms & Phenotypes for Myositis Ossificans

MGI Mouse Phenotypes related to Myositis Ossificans:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.46 ACVR1 BMP1 COL1A1 FOS
2 limbs/digits/tail MP:0005371 9.26 ACVR1 BMP1 COL1A1 FOS
3 mortality/aging MP:0010768 9.1 ACVR1 ACVR1C BMP1 COL1A1 FOS SUCLG2

Drugs & Therapeutics for Myositis Ossificans

Drugs for Myositis Ossificans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
2 Pharmaceutical Solutions Phase 2
3 Keratolytic Agents Phase 2
4 Dermatologic Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 MOVE TRIAL: A Phase 3, Efficacy and Safety Study of Oral Palovarotene for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP) Active, not recruiting NCT03312634 Phase 3 Palovarotene
2 A Phase 2 Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of a RARγ-Specific Agonist (Palovarotene) in the Treatment of Preosseous Flare-ups in Subjects With Fibrodysplasia Ossificans Progressiva (FOP) Completed NCT02190747 Phase 2 Palovarotene;Placebo
3 A Phase 2, Open-Label, Efficacy and Safety Study of an RARγ Specific Agonist (Palovarotene) to Prevent Heterotopic Ossification in Subjects With Fibrodysplasia Ossificans Progressiva (FOP) Active, not recruiting NCT02979769 Phase 2 Palovarotene dose level 1;Palovarotene dose level 2
4 A Phase 2, Open-Label Extension, Efficacy and Safety Study of a RARγ Specific Agonist (Palovarotene) in the Treatment of Preosseous Flare-ups in Subjects With Fibrodysplasia Ossificans Progressiva (FOP) Active, not recruiting NCT02279095 Phase 2 Palovarotene dose level 1;Palovarotene dose level 2;Palovarotene dose level 3;Palovarotene dose level 4
5 A Randomized, Placebo-controlled Study to Assess the Safety, Tolerability, Pharmacokinetics, and Effects on Heterotopic Bone Formation of REGN2477 in Patients With Fibrodysplasia Ossificans Progressiva Active, not recruiting NCT03188666 Phase 2 REGN2477;Matching placebo
6 A Phase 2, In-Home, Safety and Efficacy Evaluation of Episodic Administration of Open-Label Palovarotene in Subjects With Fibrodysplasia Ossificans Progressiva (FOP) Suspended NCT02521792 Phase 2 Palovarotene
7 Urine Sample Collection From Patients With Fibrodysplasia Ossificans Progressiva (FOP) for Biomarker Analysis Completed NCT02066324
8 Preoperative Evaluation of Neurogenic Myositis Ossificans or Neurogenic Para-osteo-arthritis: Comparison Between Computed Tomography and Magnetic Resonance Imaging in Preoperative Evaluation Recruiting NCT03832556
9 FOP Connection: A Global Registry for the Fibrodysplasia Ossificans Progressiva Community Recruiting NCT02745158
10 A Natural History, Non-Interventional, Two-Part Study in Subjects With Fibrodysplasia Ossificans Progressiva (FOP) Active, not recruiting NCT02322255

Search NIH Clinical Center for Myositis Ossificans

Genetic Tests for Myositis Ossificans

Anatomical Context for Myositis Ossificans

MalaCards organs/tissues related to Myositis Ossificans:

41
Bone, Brain, Spinal Cord, Breast, Lymph Node, Skeletal Muscle, Bone Marrow

Publications for Myositis Ossificans

Articles related to Myositis Ossificans:

(show top 50) (show all 1368)
# Title Authors PMID Year
1
Calcified or ossified benign soft tissue lesions that may simulate malignancy. 38
31297550 2019
2
[Myositis ossificans located at the chest wall]. 38
31373459 2019
3
Elbow Myositis Ossificans: Radiographic Evolution With Histologic Correlation. 38
30461430 2019
4
Soft tissue aneurysmal bone cyst: six new cases with imaging details, molecular pathology, and review of the literature. 38
30603771 2019
5
Fibro-osseous pseudotumor of digits and myositis ossificans show consistent COL1A1-USP6 rearrangement: a clinicopathological and genetic study of 27 cases. 38
30946936 2019
6
Expression Profiling of Receptor-Activator of Nuclear Factor-Kappa B Ligand in Soft Tissue Tumors. 38
31189751 2019
7
Pseudomalignant Myositis Ossificans of the Neck in a Child: Case Report and Review of the Literature. 38
31260851 2019
8
Feasibility of bisphosphonate therapy in an Indian pediatric patient of fibrodysplasia ossificans progressiva. 38
31041177 2019
9
Calcified leiomyoma of the deltoid: pathophysiology and imaging review. 38
30187111 2019
10
Time after time: individuals with multiple fractures and injury recidivists in long eighteenth-century (c. 1666-1837) London. 38
30245230 2019
11
[Fibrodysplasia ossificans progressiva. Report of one case]. 38
31344178 2019
12
Non-traumatic myositis ossificans of the thigh. A case report. 38
31112518 2019
13
Two cases of myositis ossificans in children, after prolonged immobilization. 38
30839310 2019
14
Nontraumatic Myositis Ossificans as an Uncommon Cause of Scoliosis: Case Report and Review of the Literature. 38
30576826 2019
15
Multifocal myositis ossificans in masticatory muscles 30 years after gunshot wound: case report and literature review. 38
27177980 2019
16
Focal Myositis of the Leg Presenting as Fever of Unknown Origin Detected by FDG PET/CT. 38
30562199 2019
17
Yoga-Induced Myositis Ossificans Traumatica of the Scapholunate Ligament. 38
30723608 2019
18
Fatal atlantoaxial dislocation due to an odontoid synchondrosis fracture in a child with chromosome 9 abnormality: A case report. 38
30528850 2019
19
Musculoskeletal "don't touch" lesions: pictorial essay. 38
30804616 2019
20
Surgical management of Gartland type III supracondylar humerus fractures in older children: a retrospectively study. 38
30614961 2019
21
High resolution ultrasound for imaging complications of muscle injury: Is there an additional role for elastography? 38
31355586 2019
22
Fibro-osseous pseudotumor on the hyponychium of the great toe. 38
30710901 2019
23
Myositis ossificans mimicking metaplastic breast cancer on core needle biopsy. 38
30641089 2019
24
Myositis ossificans of a lumbrical muscle in a child's hand. 38
30045658 2018
25
Myositis Ossificans Traumatica of the Medial Pterygoid Muscle After Third Molar Tooth Extraction: A Case Report and Review of Literature. 38
30076806 2018
26
COL1A1 is a fusionpartner of USP6 in myositis ossificans - FISH analysis of six cases. 38
29980413 2018
27
Myositis ossificans traumatica of the masticatory muscles: etiology, diagnosis and treatment. 38
30373608 2018
28
A Case of Fibrodysplasia Ossificans Progressiva in a 5-year-old Boy with all Musculoskeletal Features and Review of the Literature. 38
30740372 2018
29
Myositis Ossificans in Sport: A Review. 38
30204632 2018
30
Imaging in myositis ossificans: Bone scintigraphy and 18F-fluorodeoxyglucose positron emission tomography/computed tomography. 38
28325501 2018
31
Fibro-osseous pseudotumor of digits - Expanding the spectrum of clonal transient neoplasms harboring USP6 rearrangement. 38
29787930 2018
32
[Myositis ossificans progressia of lateral pterygoid muscle of both sides: a case report]. 38
29996370 2018
33
Fibroplasia Ossificans Progressiva: A Case Report of a Rare Disease Entity. 38
30607064 2018
34
Ankylosing Neurogenic Myositis Ossificans of the Hip: A Case Series and Review of Literature. 38
29896457 2018
35
Pseudomalignant myositis ossificans in the breast: A case report. 38
29844904 2018
36
Myositis ossificans - Another condition with USP6 rearrangement, providing evidence of a relationship with nodular fasciitis and aneurysmal bone cyst. 38
29661729 2018
37
On the importance of considering disease subtypes: Earliest detection of a parosteal osteosarcoma? Differential diagnosis of an osteosarcoma in an Anglo-Saxon female. 38
29776880 2018
38
Myositis Ossificans: Delayed Complication of Severe Muscle Contusion. 38
29712545 2018
39
Myositis Ossificans of the Masseter Muscle. 38
30787834 2018
40
Ultrasonography and return to play of the different clinical grading of quadriceps contusions: a case series. 38
28988329 2018
41
MR Imaging of Muscle Trauma: Anatomy, Biomechanics, Pathophysiology, and Imaging Appearance. 38
29220207 2018
42
Periostin expression in neoplastic and non-neoplastic diseases of bone and joint. 38
30202513 2018
43
Paratesticular myositis ossificans of the spermatic cord. 38
29301813 2018
44
[Myositis ossificans circumscripta of the hip: about a case]. 38
30100961 2018
45
MRI Findings of Early Myositis Ossificans without Calcification or Ossification. 38
30255094 2018
46
Idiopathic aggressive myositis ossificans of the hand infiltrating the flexor sheath/checkrein ligament, obliterating the common digital artery, and attenuating the digital nerve: A case report. 38
30567060 2018
47
Chondrosarcoma of the cervical spine. 38
29210904 2017
48
Surgical excision of symptomatic mature posttraumatic myositis ossificans: characteristics and outcomes in 32 athletes. 38
28780628 2017
49
Extraskeletal aneurysmal bone cyst: Report of a case and review of the literature. 38
28756986 2017
50
Outcome of Long Standing Ulno-Humeral Dislocation Managed by Open Reduction and Stabilization with V-Y Plasty; Our Experience. 38
29177172 2017

Variations for Myositis Ossificans

Expression for Myositis Ossificans

Search GEO for disease gene expression data for Myositis Ossificans.

Pathways for Myositis Ossificans

GO Terms for Myositis Ossificans

Cellular components related to Myositis Ossificans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 activin receptor complex GO:0048179 8.62 ACVR1C ACVR1

Biological processes related to Myositis Ossificans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 9.4 COL1A1 BMP1
2 response to mechanical stimulus GO:0009612 9.37 FOS COL1A1
3 pattern specification process GO:0007389 9.32 ACVR1C ACVR1
4 response to cAMP GO:0051591 9.26 FOS COL1A1
5 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.16 ACVR1C ACVR1
6 activin receptor signaling pathway GO:0032924 8.96 ACVR1C ACVR1
7 transforming growth factor beta receptor signaling pathway GO:0007179 8.8 FOS ACVR1C ACVR1

Molecular functions related to Myositis Ossificans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SMAD binding GO:0046332 9.4 ACVR1C ACVR1
2 growth factor binding GO:0019838 9.37 ACVR1C ACVR1
3 transforming growth factor beta-activated receptor activity GO:0005024 9.32 ACVR1C ACVR1
4 activin binding GO:0048185 9.26 ACVR1C ACVR1
5 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.16 ACVR1C ACVR1
6 transforming growth factor beta receptor activity, type I GO:0005025 8.96 ACVR1C ACVR1
7 activin receptor activity, type I GO:0016361 8.62 ACVR1C ACVR1

Sources for Myositis Ossificans

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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