Aliases & Classifications for Myxedema

MalaCards integrated aliases for Myxedema:

Name: Myxedema 57 12 76 55 44 15 73

Characteristics:

OMIM:

57
Inheritance:
autosomal recessive, sex-influenced
environmental factors not excluded


Classifications:



Summaries for Myxedema

MalaCards based summary : Myxedema is related to congenital hypothyroidism and graves' disease. An important gene associated with Myxedema is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are Allograft rejection and Thyroxine (Thyroid Hormone) Production. Affiliated tissues include thyroid, heart and skin, and related phenotypes are hypothyroidism and hypohidrosis

Wikipedia : 76 Myxedema or myxoedema is a term used synonymously with severe hypothyroidism. However, the term is also... more...

Description from OMIM: 255900

Related Diseases for Myxedema

Diseases related to Myxedema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
# Related Disease Score Top Affiliating Genes
1 congenital hypothyroidism 30.7 TG TPO TSHR
2 graves' disease 30.3 CTLA4 TG TPO TSHR
3 exophthalmos 29.8 TG TSHR
4 pericardial effusion 29.4 MUC16 NPPA
5 pernicious anemia 29.1 TG TPO
6 thyroiditis 29.1 CTLA4 TG TPO TSHR
7 goiter 29.0 TG TPO TSHR
8 hypothyroidism, congenital, nongoitrous, 4 28.9 TG TPO
9 hypothyroidism 28.9 CTLA4 TG TPO TSHR
10 nontoxic goiter 28.5 TG TPO TSHR
11 hyperthyroidism 28.4 CTLA4 TG TPO TSHR
12 hashimoto thyroiditis 27.9 CTLA4 TG TPO TSHR
13 thyroid cancer 27.6 TG TPO TSHR
14 autoimmune polyendocrine syndrome, type ii 11.1
15 megaloblastic anemia 1 10.9
16 hyperthyroidism, nonautoimmune 10.9
17 nodular lichen myxedematosus 10.9
18 orbital plasma cell granuloma 10.4 CTLA4 TSHR
19 chronic orbital inflammation 10.3 CTLA4 TSHR
20 hyperthyroxinemia 10.3 TPO TSHR
21 syndrome of inappropriate antidiuretic hormone 10.2 AVP NPPA
22 heart disease 10.0
23 benign struma ovarii 10.0 TG TSHR
24 hypoadrenocorticism, familial 10.0 CTLA4 TPO
25 cardiac tamponade 10.0
26 athyreosis 10.0 TG TSHR
27 hypothyroidism, congenital, nongoitrous, 2 10.0 TG TSHR
28 respiratory failure 9.9
29 megacolon 9.9
30 hemopericardium 9.9
31 myopathy 9.9
32 depression 9.9
33 papillary thyroid microcarcinoma 9.9 TG TSHR
34 vitiligo-associated multiple autoimmune disease susceptibility 1 9.9 CTLA4 TPO
35 familial thyroid dyshormonogenesis 9.8 TG TPO
36 subacute lymphocytic thyroiditis 9.8 TG TPO
37 myasthenia gravis 9.8
38 diabetes mellitus 9.8
39 sleep apnea 9.8
40 palmoplantar keratosis 9.8
41 myasthenia gravis congenital 9.8
42 cardiogenic shock 9.8
43 goiter, multinodular 1, with or without sertoli-leydig cell tumors 9.8 TG TPO
44 plummer's disease 9.8 TG TPO
45 premature menopause 9.7 TG TPO
46 apnea, obstructive sleep 9.7
47 arteries, anomalies of 9.7
48 lung cancer 9.7
49 coronary artery anomaly 9.7
50 cardiac arrest 9.7

Graphical network of the top 20 diseases related to Myxedema:



Diseases related to Myxedema

Symptoms & Phenotypes for Myxedema

Symptoms via clinical synopsis from OMIM:

57
Endocrine:
hypothyroidism

Misc:
fatigue
lethargy
weakness
cold intolerance
thyrotoxicosis in relatives
more
Neuro:
paresthesias
decreased memory

Lab:
high tsh
low free t4

GI:
constipation

Muscle:
muscle cramps

Skin:
decreased sweating
coarse, dry skin
puffy, non-pitting swelling of face, hands and limbs

Voice:
husky


Clinical features from OMIM:

255900

Human phenotypes related to Myxedema:

32 (show all 12)
# Description HPO Frequency HPO Source Accession
1 hypothyroidism 32 HP:0000821
2 hypohidrosis 32 HP:0000966
3 lethargy 32 HP:0001254
4 muscle weakness 32 HP:0001324
5 hoarse voice 32 HP:0001609
6 constipation 32 HP:0002019
7 memory impairment 32 HP:0002354
8 increased thyroid-stimulating hormone level 32 HP:0002925
9 easy fatigability 32 HP:0003388
10 muscle cramps 32 HP:0003394
11 paresthesia 32 HP:0003401
12 fatigue 32 HP:0012378

Drugs & Therapeutics for Myxedema

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Lipid Metabolic Status in Thyroid Carcinoma Completed NCT01487057

Search NIH Clinical Center for Myxedema

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: myxedema

Genetic Tests for Myxedema

Anatomical Context for Myxedema

MalaCards organs/tissues related to Myxedema:

41
Thyroid, Heart, Skin, Pituitary, Colon, Testes, Bone

Publications for Myxedema

Articles related to Myxedema:

(show top 50) (show all 573)
# Title Authors Year
1
Myxedema Coma Following the Administration of Gonadotropin-releasing Hormone Agonist Complicated by Acute Pancreatitis. ( 29877268 )
2018
2
Myxedema Coma. ( 29504346 )
2018
3
Myasthenic Crisis Complicated with Myxedema, Positive for Both Anti-acetylcholine Receptor and Anti-muscle-specific Tyrosine Kinase Antibodies. ( 29093409 )
2018
4
Response to topical halcinonide following fractional carbon dioxide laser pretreatment in a pretibial myxedema patient. ( 29363626 )
2018
5
Utility of rituximab treatment for exophthalmos, myxedema, and osteoarthropathy syndrome resistant to corticosteroids due to Graves' disease: a case report. ( 29448964 )
2018
6
Amiodarone induced myxedema coma: Two case reports and literature review. ( 29793782 )
2018
7
Myxedema Coma due to Hashimoto Thyroiditis: A Rare but Real Presentation of Failure to Thrive in Infancy. ( 29730659 )
2018
8
Pretibial myxedema in a euthyroid patient. ( 29858862 )
2018
9
Undiagnosed myxedema coma: Rare but life-threatening. ( 29416497 )
2018
10
Case of myxedema coma induced by lithium carbonate in a patient with schizophrenia. ( 29232051 )
2018
11
Treatment of pretibial myxedema with intralesional immunomodulating therapy. ( 28932121 )
2017
12
Myxedema coma: A case report of pediatric emergency care. ( 28538388 )
2017
13
Thoracentesis-reverting cardiac tamponade physiology in a patient with myxedema coma and large pleural effusion. ( 28670061 )
2017
14
Routine Treatment-Resistant<i>Clostridium difficile</i>Infection during Recovery from Myxedema. ( 29430228 )
2017
15
Annularly arranged nodular pretibial myxedema after 7-year treatment of Graves' disease. ( 28150342 )
2017
16
Pretibial Myxedema Masquerading as a Venous Leg Ulcer. ( 28355140 )
2017
17
Myxedema Crisis Presenting with Seizures: A Rare Life-Threatening Presentation-A Case Report and Review of the Literature. ( 28540093 )
2017
18
Split high-dose oral levothyroxine treatment as a successful therapy option in myxedema coma. ( 29026577 )
2017
19
Clinical characteristics and outcomes of myxedema coma: Analysis of a national inpatient database in Japan. ( 28142035 )
2017
20
Sudden cardiac arrest as a rare presentation of myxedema coma: case report. ( 29147476 )
2017
21
Elephantiasic Pretibial Myxedema with Involvement of the Buttocks and Face. ( 28748868 )
2017
22
Diagnosis of myxedema coma complicated by renal failure: a case report. ( 28396755 )
2017
23
Rapid Response to Loading Dose Levothyroxine in Myxedema Psychosis. ( 28102974 )
2017
24
Nivolumab induced myxedema crisis. ( 28239466 )
2017
25
Myxedema Psychosis in a Patient With Undiagnosed Hashimoto Thyroiditis. ( 28055088 )
2017
26
Unusual Case of a Massive Macroglossia Secondary to Myxedema: A Case Report and Literature Review. ( 28742994 )
2017
27
Intracerebral Bleeding and Massive Pericardial Effusion as Presenting Symptoms of Myxedema Crisis. ( 28255471 )
2017
28
Morbidity and Mortality Risks of Premature Enteral Nutrition During the Recovery of Myxedema Coma (A Response to the Article Entitled &amp;quot;Pediatric Patient With Altered Mental Status and Hypoxemia&amp;quot;). ( 27583414 )
2016
29
A rabbit model of fatal hypothyroidism mimicking &amp;quot;myxedema coma&amp;quot; established by microscopic total thyroidectomy. ( 26924647 )
2016
30
An Atypical Case of Myxedema Coma with Concomitant Nonconvulsive Seizure. ( 27872766 )
2016
31
Myxedema Coma Secondary to Central Hypothyroidism: A Rare but Real Cause of Altered Mental Status in Pediatrics. ( 27631398 )
2016
32
Periorbital Myxedema. ( 27802562 )
2016
33
Impending myxedema coma as the initial presentation of lung cancer. ( 27823924 )
2016
34
Injected Hyaluronidase Reduces the Volume of Exogenous Hyaluronate Fillers in Mice and Results in Clinical Improvement in a Patient with Pretibial Myxedema. ( 27504447 )
2016
35
Polypoid and fungating form of elephantiasic pretibial myxedema with involvement of the hands. ( 26873132 )
2016
36
Morphological Diversity of Pretibial Myxedema and Its Mechanism of Evolving Process and Outcome: A Retrospective Study of 216 Cases. ( 27648339 )
2016
37
Myxedema Ascites: A Rare Presentation of Uncontrolled Hypothyroidism. ( 28083456 )
2016
38
Radiation therapy as part of the therapeutic regimen for extensive multilocular myxedema in a patient with exophthalmos, myxedema and osteoarthropathy syndrome: A case report. ( 26137080 )
2015
39
Nodular Foot Myxedema Masquerading as Lymphedema. ( 26301146 )
2015
40
Eczema craquelAc, an uncommon clinical manifestation of myxedema. ( 25918092 )
2015
41
Computed tomography and magnetic resonance imaging findings of ureteral myxedema in Graves' disease. ( 25766333 )
2015
42
Myxedema madness complicating postoperative follow-up of thyroid cancer. ( 26331326 )
2015
43
Pre-tibial myxedema: treatment with intralesional corticosteroid. ( 26312698 )
2015
44
Images in clinical medicine. Myxedema. ( 25693016 )
2015
45
A Randomized Controlled Trial of Intralesional Glucocorticoid for Treating Pretibial Myxedema. ( 26491499 )
2015
46
Myxedema coma with cardiac tamponade and severe cardiomyopathy. ( 26424958 )
2015
47
Myxedema madness: a case for short-term antipsychotics? ( 25870443 )
2015
48
Development of an objective tool for the diagnosis of myxedema coma. ( 25647622 )
2015
49
Dermoscopy of pretibial myxedema. ( 26568347 )
2015
50
Second degree AV block and severely impaired contractility in cardiac myxedema: a case report. ( 26000037 )
2015

Variations for Myxedema

Expression for Myxedema

Search GEO for disease gene expression data for Myxedema.

Pathways for Myxedema

GO Terms for Myxedema

Cellular components related to Myxedema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 AVP MUC16 NPPA TG TPO

Biological processes related to Myxedema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.43 AVP NPPA TG
2 regulation of blood vessel size GO:0050880 9.16 AVP NPPA
3 obsolete positive regulation of cAMP biosynthetic process GO:0030819 8.96 AVP TSHR
4 hormone biosynthetic process GO:0042446 8.62 TG TPO

Molecular functions related to Myxedema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 9.16 AVP NPPA
2 hormone activity GO:0005179 9.13 AVP NPPA TG
3 protein-hormone receptor activity GO:0016500 8.62 LGR6 TSHR

Sources for Myxedema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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