Aliases & Classifications for Myxedema

MalaCards integrated aliases for Myxedema:

Name: Myxedema 58 12 77 56 45 15 17 74

Characteristics:

OMIM:

58
Inheritance:
autosomal recessive, sex-influenced
environmental factors not excluded


HPO:

33
myxedema:
Inheritance autosomal recessive inheritance


Classifications:



Summaries for Myxedema

MalaCards based summary : Myxedema is related to graves' disease and congenital hypothyroidism. An important gene associated with Myxedema is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Allograft rejection. Affiliated tissues include thyroid, pituitary and skin, and related phenotypes are hypothyroidism and muscle weakness

Wikipedia : 77 Myxedema is a term used synonymously with severe hypothyroidism. However, the term is also used to... more...

Description from OMIM: 255900

Related Diseases for Myxedema

Diseases related to Myxedema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)
# Related Disease Score Top Affiliating Genes
1 graves' disease 31.5 CTLA4 TG TPO TSHR
2 congenital hypothyroidism 31.4 TG TPO TSHR
3 exophthalmos 30.4 TG TSHR
4 pericardial effusion 30.1 MUC16 NPPA
5 goiter 30.0 TG TPO TSHR
6 graves disease 1 30.0 TG TPO TSHR
7 hypothyroidism 30.0 CTLA4 TG TPO TSHR
8 hyperthyroidism 29.8 CTLA4 TG TPO TSHR
9 pernicious anemia 29.7 TG TPO
10 thyroiditis 29.6 CTLA4 TG TPO TSHR
11 thyroid cancer 29.3 TG TPO TSHR
12 hashimoto thyroiditis 29.3 CTLA4 TG TPO TSHR
13 hypothyroidism, congenital, nongoitrous, 4 29.2 TG TPO
14 nontoxic goiter 29.2 TG TPO TSHR
15 autoimmune polyendocrine syndrome, type ii 11.3
16 megaloblastic anemia 1 11.1
17 hyperthyroidism, nonautoimmune 11.1
18 nodular lichen myxedematosus 11.1
19 ocular motor apraxia 10.7
20 heart disease 10.3
21 cardiac tamponade 10.3
22 hemopericardium 10.2
23 orbital plasma cell granuloma 10.2 CTLA4 TSHR
24 hashimoto encephalopathy 10.2 TPO TSHR
25 chronic orbital inflammation 10.2 CTLA4 TSHR
26 respiratory failure 10.1
27 hyperthyroxinemia 10.1 TPO TSHR
28 myopathy 10.1
29 rere-related disorders 10.1
30 syndrome of inappropriate antidiuretic hormone 10.1 AVP NPPA
31 myasthenia gravis 10.0
32 meconium ileus 10.0
33 megacolon 10.0
34 myasthenia gravis congenital 10.0
35 cardiogenic shock 10.0
36 benign struma ovarii 10.0 TG TSHR
37 athyreosis 10.0 TG TSHR
38 congestive heart failure 10.0
39 diabetes mellitus 10.0
40 sleep apnea 10.0
41 hyperparathyroidism 10.0
42 palmoplantar keratosis 10.0
43 neuropathy 10.0
44 depression 10.0
45 myotonia 10.0
46 postsurgical hypothyroidism 10.0 TG TSHR
47 hypothyroidism, congenital, nongoitrous, 2 10.0 TG TSHR
48 hypoadrenocorticism, familial 9.9 CTLA4 TPO
49 subacute lymphocytic thyroiditis 9.9 TG TPO
50 papillary thyroid microcarcinoma 9.9 TG TSHR

Graphical network of the top 20 diseases related to Myxedema:



Diseases related to Myxedema

Symptoms & Phenotypes for Myxedema

Human phenotypes related to Myxedema:

33 (show all 14)
# Description HPO Frequency HPO Source Accession
1 hypothyroidism 33 HP:0000821
2 muscle weakness 33 HP:0001324
3 constipation 33 HP:0002019
4 fatigue 33 HP:0012378
5 dry skin 33 HP:0000958
6 hypohidrosis 33 HP:0000966
7 goiter 33 HP:0000853
8 memory impairment 33 HP:0002354
9 paresthesia 33 HP:0003401
10 easy fatigability 33 HP:0003388
11 hoarse voice 33 HP:0001609
12 lethargy 33 HP:0001254
13 increased thyroid-stimulating hormone level 33 HP:0002925
14 muscle spasm 33 HP:0003394

Symptoms via clinical synopsis from OMIM:

58
Endocrine:
hypothyroidism

Misc:
fatigue
lethargy
weakness
cold intolerance
thyrotoxicosis in relatives
more
Neuro:
paresthesias
decreased memory

Lab:
high tsh
low free t4

G I:
constipation

Muscle:
muscle cramps

Skin:
decreased sweating
coarse, dry skin
puffy, non-pitting swelling of face, hands and limbs

Voice:
husky

Clinical features from OMIM:

255900

Drugs & Therapeutics for Myxedema

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Lipid Metabolic Status in Thyroid Carcinoma Completed NCT01487057

Search NIH Clinical Center for Myxedema

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: myxedema

Genetic Tests for Myxedema

Anatomical Context for Myxedema

MalaCards organs/tissues related to Myxedema:

42
Thyroid, Pituitary, Skin, Colon, T Cells, Bone, Heart

Publications for Myxedema

Articles related to Myxedema:

(show top 50) (show all 850)
# Title Authors Year
1
Mechanical Circulatory Support in Management of Cardiogenic Shock and Myxedema Coma. ( 30956822 )
2019
2
A Case of Violent Suicide Attempt in a Context of Myxedema Psychosis following Radioiodine Treatment in a Patient with Graves' Disease. ( 30729057 )
2019
3
Myxedema Heart Disease: A Rare Disease Entity: Case Report and Brief Review of the Literature. ( 30277162 )
2019
4
Critical Consideration of Myxedema Coma in the Postoperative Setting: A Case Report. ( 30169383 )
2019
5
Pretibial myxedema. ( 30337109 )
2019
6
Myxedema coma precipitated by diabetic ketoacidosis after total thyroidectomy: a case report. ( 30827279 )
2019
7
Successful treatment of myxedema coma with a combination of levothyroxine and liothyronine. ( 30853666 )
2019
8
Clinical Experience with Rituximab and Intravenous Immunoglobulin for Pretibial myxedema: A Case Series. ( 30854936 )
2019
9
Electrosurgical debulking of pretibial myxedema of the foot. ( 30865416 )
2019
10
Thyroxine-Induced Preradial Myxedema. ( 30984592 )
2019
11
Myxedema Coma Following the Administration of Gonadotropin-releasing Hormone Agonist Complicated by Acute Pancreatitis. ( 29877268 )
2018
12
Utility of rituximab treatment for exophthalmos, myxedema, and osteoarthropathy syndrome resistant to corticosteroids due to Graves' disease: a case report. ( 29448964 )
2018
13
Annularly arranged nodular pretibial myxedema after 7-year treatment of Graves' disease. ( 28150342 )
2018
14
Myxedema Coma due to Hashimoto Thyroiditis: A Rare but Real Presentation of Failure to Thrive in Infancy. ( 29730659 )
2018
15
Myxedema Ascites: An Unusual Presentation of Uncontrolled Hypothyroidism. ( 30027019 )
2018
16
Unusual Case of a Massive Macroglossia Secondary to Myxedema: A Case Report and Literature Review. ( 28742994 )
2018
17
Myasthenic Crisis Complicated with Myxedema, Positive for Both Anti-acetylcholine Receptor and Anti-muscle-specific Tyrosine Kinase Antibodies. ( 29093409 )
2018
18
Case of myxedema coma induced by lithium carbonate in a patient with schizophrenia. ( 29232051 )
2018
19
Response to topical halcinonide following fractional carbon dioxide laser pretreatment in a pretibial myxedema patient. ( 29363626 )
2018
20
Undiagnosed myxedema coma: Rare but life-threatening. ( 29416497 )
2018
21
Myxedema Coma. ( 29504346 )
2018
22
Amiodarone induced myxedema coma: Two case reports and literature review. ( 29793782 )
2018
23
Pretibial myxedema in a euthyroid patient. ( 29858862 )
2018
24
Das Myxödemherz: The Myxedema Heart Herman Zondek 1887-1979. ( 30152719 )
2018
25
Pretibial myxedema successfully treated with intralesional hyaluronidase. ( 30306115 )
2018
26
Postoperative myxedema coma in patients undergoing major surgery: Case series. ( 30454972 )
2018
27
Intralesional and topical glucocorticoids for pretibial myxedema: A case report and review of literature. ( 30510955 )
2018
28
Sudden cardiac arrest as a rare presentation of myxedema coma: case report. ( 29147476 )
2017
29
Thoracentesis-reverting cardiac tamponade physiology in a patient with myxedema coma and large pleural effusion. ( 28670061 )
2017
30
Myxedema Psychosis in a Patient With Undiagnosed Hashimoto Thyroiditis. ( 28055088 )
2017
31
Myxedema Coma Secondary to Central Hypothyroidism: A Rare but Real Cause of Altered Mental Status in Pediatrics. ( 27631398 )
2017
32
Impending myxedema coma as the initial presentation of lung cancer. ( 27823924 )
2017
33
Rapid Response to Loading Dose Levothyroxine in Myxedema Psychosis. ( 28102974 )
2017
34
Clinical characteristics and outcomes of myxedema coma: Analysis of a national inpatient database in Japan. ( 28142035 )
2017
35
Nivolumab induced myxedema crisis. ( 28239466 )
2017
36
Intracerebral Bleeding and Massive Pericardial Effusion as Presenting Symptoms of Myxedema Crisis. ( 28255471 )
2017
37
Pretibial Myxedema Masquerading as a Venous Leg Ulcer. ( 28355140 )
2017
38
Diagnosis of myxedema coma complicated by renal failure: a case report. ( 28396755 )
2017
39
Myxedema coma: A case report of pediatric emergency care. ( 28538388 )
2017
40
Myxedema Crisis Presenting with Seizures: A Rare Life-Threatening Presentation-A Case Report and Review of the Literature. ( 28540093 )
2017
41
Elephantiasic Pretibial Myxedema with Involvement of the Buttocks and Face. ( 28748868 )
2017
42
Treatment of pretibial myxedema with intralesional immunomodulating therapy. ( 28932121 )
2017
43
Split high-dose oral levothyroxine treatment as a successful therapy option in myxedema coma. ( 29026577 )
2017
44
Routine Treatment-Resistant Clostridium difficile Infection during Recovery from Myxedema. ( 29430228 )
2017
45
Burn-induced Myxedema Crisis. ( 29849399 )
2017
46
Myxedema Ascites: A Rare Presentation of Uncontrolled Hypothyroidism. ( 28083456 )
2016
47
A rabbit model of fatal hypothyroidism mimicking "myxedema coma" established by microscopic total thyroidectomy. ( 26924647 )
2016
48
Polypoid and fungating form of elephantiasic pretibial myxedema with involvement of the hands. ( 26873132 )
2016
49
Injected Hyaluronidase Reduces the Volume of Exogenous Hyaluronate Fillers in Mice and Results in Clinical Improvement in a Patient with Pretibial Myxedema. ( 27504447 )
2016
50
Morbidity and Mortality Risks of Premature Enteral Nutrition During the Recovery of Myxedema Coma (A Response to the Article Entitled "Pediatric Patient With Altered Mental Status and Hypoxemia"). ( 27583414 )
2016

Variations for Myxedema

Expression for Myxedema

Search GEO for disease gene expression data for Myxedema.

Pathways for Myxedema

GO Terms for Myxedema

Biological processes related to Myxedema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.33 AVP NPPA TG
2 regulation of blood vessel size GO:0050880 8.96 AVP NPPA
3 hormone biosynthetic process GO:0042446 8.62 TG TPO

Molecular functions related to Myxedema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 9.16 AVP NPPA
2 hormone activity GO:0005179 9.13 AVP NPPA TG
3 protein-hormone receptor activity GO:0016500 8.62 LGR6 TSHR

Sources for Myxedema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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