Myxofibrosarcoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MYX013 MIFTS: 40	Myxofibrosarcoma Categories: Neuronal diseases, Rare diseases, Skin diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Download Expand all tables

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Aliases & Classifications for Myxofibrosarcoma

MalaCards integrated aliases for Myxofibrosarcoma:

Name: Myxofibrosarcoma ⁵⁹

Fibromyxosarcoma ⁵⁹ ⁷³

Dermatofibrosarcoma Protuberans, Myxoid ⁷³

Myxoid Malignant Fibrous Histiocytoma ⁵⁹

Characteristics:

Orphanet epidemiological data:

⁵⁹

myxofibrosarcoma
Inheritance: Not applicable; Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Skin diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Neoplasms

Malignant neoplasms of mesothelial and soft tissue

Malignant neoplasm of other connective and soft tissue

Malignant neoplasm: Connective and soft tissue, unspecified

Orphanet: ⁵⁹

Rare neurological diseases

External Ids:

Orphanet ⁵⁹ ORPHA79105

UMLS via Orphanet ⁷⁴ C3714524

ICD10 via Orphanet ³⁴ C49.9

UMLS ⁷³ C3714524 C0334454

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Summaries for Myxofibrosarcoma

MalaCards based summary : Myxofibrosarcoma, also known as fibromyxosarcoma, is related to malignant fibroxanthoma and embryonal sarcoma. An important gene associated with Myxofibrosarcoma is CREB3L1 (CAMP Responsive Element Binding Protein 3 Like 1), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Kaposi's sarcoma-associated herpesvirus infection. The drugs Doxorubicin and Mechlorethamine have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and bone.

Wikipedia : ⁷⁶ A histiocytoma is a tumour consisting of histiocytes. Histiocytes are cells that are a part of the... more...

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Related Diseases for Myxofibrosarcoma

Diseases related to Myxofibrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)

#	Related Disease	Score	Top Affiliating Genes
1	malignant fibroxanthoma	30.1	DES MKI67 S100B
2	embryonal sarcoma	29.9	DES MKI67 S100B
3	fibrous histiocytoma	29.3	DES FUS S100B
4	dermatofibrosarcoma protuberans	29.3	DES S100B
5	malignant triton tumor	10.6	DES S100B
6	ossifying fibromyxoid tumor	10.6	DES S100B
7	syringocystadenoma papilliferum	10.6	DES S100B
8	spindle cell rhabdomyosarcoma	10.6	DES S100B
9	syringoma	10.6	DES S100B
10	juvenile xanthogranuloma	10.6	DES S100B
11	pleomorphic liposarcoma	10.6	DES S100B
12	pulmonary vein stenosis	10.6	DES MKI67
13	cutaneous fibrous histiocytoma	10.6	DES S100B
14	spindle cell sarcoma	10.5	DES S100B
15	adenosarcoma	10.5	DES MKI67
16	granular cell tumor	10.5	DES S100B
17	hemangiopericytoma, malignant	10.5	DES S100B
18	hidradenocarcinoma	10.4	MKI67 S100B
19	polymorphous low-grade adenocarcinoma	10.4	MKI67 S100B
20	odontogenic myxoma	10.4	CD36 S100B
21	neurilemmoma	10.3	DES S100B
22	pseudosarcomatous fibromatosis	10.3	CREB3L2 DES
23	atypical teratoid rhabdoid tumor	10.3	DES S100B
24	pilomatrixoma	10.3	CD36 S100B
25	babesiosis	10.2	CD36 THBS1
26	inflammatory myofibroblastic tumor	10.2	DES MKI67 S100B
27	sarcoma	10.2
28	gastrointestinal stromal tumor	10.2	DES MKI67 S100B
29	muscle cancer	10.2	CREB3L2 DES
30	ependymoma	10.1	MKI67 S100B
31	undifferentiated pleomorphic sarcoma	10.0
32	liposarcoma	10.0
33	extraskeletal ewing sarcoma	10.0	DES FUS
34	lipomatosis, multiple	9.9	DES FUS
35	histiocytoma	9.9
36	myxoid liposarcoma	9.9
37	burn scar	9.9
38	burns	9.9
39	sclerosing liposarcoma	9.8	CREB3L2 FUS
40	mixed liposarcoma	9.8	CREB3L2 FUS
41	atypical lipomatous tumor	9.8	CREB3L2 FUS
42	chondroid lipoma	9.8	CREB3L2 FUS
43	cervicitis	9.7
44	dedifferentiated liposarcoma	9.7
45	fibrosarcoma	9.7
46	cerebritis	9.7
47	neurofibrosarcoma	9.7
48	carpal tunnel syndrome	9.7
49	prostate cancer	9.7
50	cellular myxoid liposarcoma	9.7

Graphical network of the top 20 diseases related to Myxofibrosarcoma:

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Symptoms & Phenotypes for Myxofibrosarcoma

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Drugs & Therapeutics for Myxofibrosarcoma

Drugs for Myxofibrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Doxorubicin

Approved, Investigational

Phase 2, Phase 3,Phase 1

23214-92-8

31703

Synonyms:

(1S,3S)-3-Glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranoside

(1S,3S)-3-Glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside

(1S,3S)-3-Glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside

(8S-cis)-10-((3-amino-2,3,6-Trideoxy-a-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione

(8S-cis)-10-((3-amino-2,3,6-Trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione

(8S-cis)-10-((3-amino-2,3,6-Trideoxy-α-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione

111266-55-8

14-hydroxydaunomycin

14-Hydroxydaunomycin

14-hydroxydaunorubicine

14-Hydroxydaunorubicine

23214-92-8

23257-17-2

24385-08-8

25311-50-6

25316-40-9

25316-40-9 (hydrochloride)

29042-30-6

AC1L1M5T

AC1Q29OJ

adiblastine (hydrochloride salt)

ADM

ADR

adr iablatina (hydrochloride salt)

Adriablastin

Adriablastine

adriablastine (hydrochloride salt)

adriablatina (hydrochloride salt)

Adriacin (hydrochloride salt)

Adriamycin

Adriamycin PFS

Adriamycin PFS (hydrochloride salt)

Adriamycin RDF

Adriamycin RDF (hydrochloride salt)

Adriamycin semiquinone

Adriamycin Semiquinone

Adriblas tina

Adriblastin

Adriblastina

Adriblastina (hydrochloride salt)

Adriblastina (TN)

Adriblastine

adriblatina (hydrochloride salt)

Adrimedac

Aerosolized Doxorubicin

Baxter brand OF doxorubicin hydrochloride

Bedford brand OF doxorubicin hydrochloride

BPBio1_000502

BRD-K92093830-003-04-3

Bristol-myers squibb brand OF doxorubicin hydrochloride

BSPBio_000456

BSPBio_001031

C01661

C27H29NO11

Caelyx

CCRIS 739

Cell pharm brand OF doxorubicin hydrochloride

CHEBI:28748

CHEMBL179

CID31703

Columbia brand OF doxorubicin hydrochloride

Conjugate of doxorubicin with humanized monoclonal antibody LL1 against CD74

Conjugate of doxorubicin with monoclonal antibody P4/D10 against GP120

D03899

DB00997

DM2

Doxil

Doxo

doxo Cell

doxo-Cell

Doxolem

doxorubicin

Doxorubicin

Doxorubicin (USAN/INN)

Doxorubicin [USAN:INN:BAN]

Doxorubicin citrate

Doxorubicin HCl

Doxorubicin hexal

Doxorubicin hydrochloride

Doxorubicin Hydrochloride

Doxorubicin hydrochloride (hydrochloride salt)

Doxorubicin NC

Doxorubicina

Doxorubicina [INN-Spanish]

Doxorubicina ferrer farm

Doxorubicina funk

Doxorubicina tedec

Doxorubicine

Doxorubicine [INN-French]

Doxorubicine baxter

Doxorubicin-hLL1

Doxorubicin-hLL1 conjugate

Doxorubicin-P4/D10

Doxorubicin-P4/D10 conjugate

Doxorubicinum

Doxorubicinum [INN-Latin]

Doxotec

DOX-SL

EINECS 245-495-6

Elan brand OF doxorubicin hydrochloride

Farmablastina (hydrochloride salt)

Farmiblastina

Ferrer brand OF doxorubicin hydrochloride

FI 106

Hexal brand OF doxorubicin hydrochloride

HMS2089H06

HSDB 3070

Hydrochloride, doxorubicin

Hydroxydaunomycin hydrochlor ide (hydrochloride salt)

Hydroxydaunomycin hydrochloride (hydrochloride salt)

Hydroxydaunorubicin

Hydroxydaunorubicin hydrochloride (hydrochloride salt)

JT9100000

Kenfarma brand OF doxorubicin hydrochloride

Lemery brand OF doxorubicin hydrochloride

LMPK13050001

LS-1029

LS-165655

Medac brand OF doxorubicin hydrochloride

MLS000759533

Myocet

NChemBio.2007.10-comp13

nchembio809-comp5

NCI-C01514

NDC 38242-874

Neocorp brand OF doxorubicin hydrochloride

NIOSH/JT9100000

NSC 123127

Onkodox

Onkoworks brand OF doxorubicin hydrochloride

Pfizer brand OF doxorubicin hydrochloride

Prasfarma brand OF doxorubicin hydrochloride

Prestwick0_000438

Prestwick1_000438

Prestwick2_000438

Prestwick3_000438

Probes1_000151

Probes2_000129

RDF Rubex

Resmycin

Ribodoxo

Ribosepharm brand OF doxorubicin hydrochloride

Rubex

Rubex (hydrochloride salt)

SMP1_000106

SPBio_002395

Tedec meiji brand OF doxorubicin hydrochloride

ThermoDox

TLC D-99

Triferric doxorubicin

UNII-80168379AG

Urokit doxo cell

Urokit doxo-cell

Mechlorethamine

Approved, Investigational

Phase 2, Phase 3

51-75-2

4033

Synonyms:

.Beta.,.beta.'-Dichlorodiethyl-N-methylamine

1, 5-Dichloro-3-methyl-3-azapentane hydrochloride

126-85-2 (N-oxide)

2,2'-Dichlorodiethyl-methylamine

2,2'-Dichloro-N-me

2,2'-dichloro-N-methyldiethylamine

2,2'-dichloro-N-Methyldiethylamine

2,2'-Dichloro-N-methyldiethylamine

2-Chloro-N-(2-chloroethyl)-N-methylethanamine

302-70-5 (N-oxide, hydrochloride)

51-75-2

55-86-7 (HYDROCHLORIDE)

AC1L1H9H

Antimit

b,Beta'-dichlorodiethyl-N-methylamine

beta,beta'-Dichlorodiethyl-N-methylamine

beta,Beta'-dichlorodiethyl-N-methylamine

Bis(2-chloroethyl)methylamine

Bis(b-chloroethyl)methylamine

Bis(beta-chloroethyl) methylamine

Bis(beta-chloroethyl)methylamine

Bis(β-chloroethyl)methylamine

BRN 0605323

BSPBio_001947

C07115

C5H11Cl2N

Carolysine

Caryolysin

Caryolysine

CCRIS 447

CHEBI:28925

CHEMBL427

Chloramine (the nitrogen mustard)

Chlorethazine

Chlormethine

Chlormethine (INN)

Chlormethine [INN:BAN]

Chlormethinum [INN-Latin]

CID4033

Cloramin

Clormetina

Clormetina [INN-Spanish]

D07671

DB00888

Di(2-chloroethyl)methylamine

Dichlor amine

Dichloren

DivK1c_000759

EINECS 200-120-5

Embechine

Embichin

ENT-25294

HMS1920J15

HMS2091B04

HMS502F21

HN2

HN-2

HSDB 5083

Hydrochloride N-oxide, mechlorethamine

Hydrochloride, mechlorethamine

I14-8708

IBS-L0033631

IDI1_000759

KBio1_000759

KBio2_001369

KBio2_003937

KBio2_006505

KBio3_001447

KBioGR_001448

KBioSS_001369

LS-7559

MBA

Me chloroethamine

Mebichloramine

mechlorethamine

Mechlorethamine

Mechlorethamine hydrochloride

Mechlorethamine hydrochloride N oxide

Mechlorethamine hydrochloride N-oxide

Mechlorethamine N oxide

Mechlorethamine N-oxide

Mechlorethamine oxide

Mechlorethanamine

Mechloroethamine

Mecloretamina

Mecloretamina [Italian]

Merck brand OF mechlorethamine hydrochloride

Merck frosst brand OF mechlorethamine hydrochloride

Methylbis(2-chloroethyl)amine

Methylbis(b-chloroethyl)amine

Methylbis(beta-chloroethyl)amine

Methylbis(β-chloroethyl)amine

Methylchlorethamine

Methyldi(2-chloroethyl)amine

Mitomen

Mitoxine (*Hydrochloride*)

MolPort-001-785-592

Mustargen

Mustine

Mustine note

Mutagen

N,N-Bis(2-chloroethyl)methylamine

N,N-Bis(2-chloroethyl)-N-methylamine

N,N-Di(chloroethyl)methylamine

NCGC00091835-02

NCGC00091835-03

NCGC00091835-04

NCGC00091835-05

NCI60_041682

NINDS_000759

Nitol (*Hydrochloride*)

Nitrogen mustard

Nitrogen mustard (HN-2)

Nitrogen mustard N oxide

Nitrogen mustard N-oxide

Nitrogranulogen

Nitromin

N-Lost

N-Methyl lost

N-Methyl-2,2'-dichlorodiethylamine

N-methyl-bis(2-chloroethyl)amine

N-Methyl-bis(2-chloroethyl)amine

N-Methyl-bis(b-chloroethyl)amine

N-Methyl-bis(beta-chloroethyl)amine

N-Methyl-bis(β-chloroethyl)amine

N-Methyl-bis-chloraethylamin

N-Methyl-bis-chloraethylamin [German]

N-Methyl-lost

N-Methyl-lost [German]

N-Oxide, mechlorethamine hydrochloride

N-Oxide, nitrogen mustard

NSC 762

NSC762

NSC-762

SPBio_000496

Spectrum_000889

SPECTRUM1500375

Spectrum2_000448

Spectrum3_000484

Spectrum4_000924

Spectrum5_001702

Stickstofflost (*Hydrochloride*)

Stickstofflost (ebewe)

T 1024

T-1024

thyldiethylamine

TL 146

UNII-50D9XSG0VR

β,beta'-dichlorodiethyl-N-methylamine

β,β'-dichlorodiethyl-N-methylamine

Ifosfamide

Approved

Phase 2, Phase 3

3778-73-2

3690

Synonyms:

(+-)-Ifosfamid

(+-)-Ifosphamide

(+-)-Tetrahydro-N,3-bis(2-chloroethyl)-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

(D,L)-Ifosfamide

(R,S)-Ifosphamide

(R,S)-N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

{3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,

1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide

1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-, 2-oxide

2,3-(N,N(sup 1)-Bis(2-chloroethyl)diamido)-1,3,2-oxazaphosphoridinoxyd

2,3-N,N(sup 1)-Bis(2-chloroethyl)diamido-1,3,2-oxazaphosphoridinoxyd

2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis( 2-chloroethyl)tetrahydro-, 2-oxide

2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis(2-chloroethyl)tetrahydro-, 2-oxide

2H-1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide

2H-1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide (8CI)

2H-1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-, 2-oxide

3-(2-Chloroethyl)-2-((2-chloroethyl)amino)perhydro-2H-1,3,2-oxazaphosphorine oxide

3-(2-Chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide

3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,3,2-oxazaphosphorine oxide

3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,3,2-oxazaphosphorineoxide

3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2- oxide

3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide

3,} 2-oxazaphosphorine oxide

36341-88-5

3778-73-2

84711-20-6

A 4942

AB00513932

AC1L1GHW

AC-2113

Ambap3778-73-2

Asta Z 4942

ASTA Z 4942

BPBio1_000865

BRN 0611835

BSPBio_000785

C07047

CAS-3778-73-2

CCRIS 352

CHEBI:5864

CHEMBL1024

CID3690

Cyfos

D00343

D007069

DB01181

EINECS 223-237-3

HMS1570H07

HMS2090M12

HMS2093N07

Holoxan

Holoxan 1000

HSDB 7023

I06-0494

Ifex

IFEX (TN)

Ifosfamid

Ifosfamida

Ifosfamida [INN-Spanish]

ifosfamide

Ifosfamide (JAN/USP/INN)

Ifosfamide [USAN:INN:BAN:JAN]

Ifosfamide sterile

Ifosfamide Sterile

Ifosfamidum

Ifosfamidum [INN-Latin]

Ifosphamide

Ifsofamide

Iphosphamid

Iphosphamid(e)

Iphosphamide

I-phosphamide

I-Phosphamide

iso Endoxan

Iso Endoxan

iso-Endoxan

Isoendoxan

Iso-Endoxan

Isofosfamide

Isophosphamide

isosfamide

Isosfamide

LS-102

LS-99799

Mitoxana

Mitoxana, Ifex, Ifosfamide

MJF 9325

MJF-9325

MLS002154021

MolPort-003-666-704

N-(2-Chloraethyl)-N'-(2-chloraethyl)-N',O-propylen-phosphorsaureester-diamid

N-(2-Chloraethyl)-N'-(2-chloraethyl)-N',O-propylen-phosphorsaureester-diamid [German]

N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylen ephosphoric acid diamide

N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylene phosphoric acid ester diamide

N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylenephosphoric acid diamide

N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide

N-(2-Chloroethyl)-N-(3-(2-chloroethyl)-2-oxido-1,3,2-oxazaphosphinan-2-yl)amine

N,3-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide

N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

N,N-Bis(beta-chloroethyl)-amino-N',O-propylene-phosphoric acid ester diamide

Naxamide

NCGC00016639-01

NCGC00179435-01

NCI60_000233

NCI-C01638

NPFAPI-04

NSC 109,724

NSC 109724

NSC109,724

NSC-109,724

NSC109724

NSC-109724

Prestwick0_000833

Prestwick1_000833

Prestwick2_000833

Prestwick3_000833

S1302_Selleck

SMR001233348

SPBio_002706

STL058690

UNII-UM20QQM95Y

WLN: T6NPOTJ AM2G BO B2G

Z 4942

Z4942

Z-4942

Cyclophosphamide

Approved, Investigational

Phase 2, Phase 3

50-18-0, 6055-19-2

2907

Synonyms:

(-)-Cyclophosphamide

(+-)-Cyclophosphamide

(RS)-Cyclophosphamide

1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine

1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin

2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide

4-Hydroxy-cyclophosphan-mamophosphatide

50-18-0

60007-95-6

6055-19-2 (monohydrate)

75526-90-8

AC1L1EQQ

AI3-26198

Anhydrous cyclophosphamide

Anhydrous, cyclophosphamide

ASTA

Asta B 518

ASTA B518

B 518

B-518

bis(2-Chloroethyl)phosphami de cyclic propanolamide

bis(2-Chloroethyl)phosphamide cyclic propanolamide ester

Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester

BRN 0011744

BSPBio_002099

C 0768

C07888

C7H15Cl2N2O2P

CB 4564

CB-4564

CCRIS 188

CHEBI:4027

CHEMBL32520

CHEMBL88

Ciclofosfamida

Ciclofosfamida [INN-Spanish]

Ciclofosfamide

Ciclophosphamide

Ciclophosphamide [INN]

CID2907

Clafen

Claphene

CPA

CTX

Cycloblastin

Cyclophosphamid

cyclophosphamide

Cyclophosphamide

Cyclophosphamide (anhydrous form)

Cyclophosphamide (anhydrous)

Cyclophosphamide (INN)

Cyclophosphamide (TN)

Cyclophosphamide anhydrous

Cyclophosphamide monohydrate

Cyclophosphamide Monohydrate

Cyclophosphamide Sterile

Cyclophosphamide, (+-)-Isomer

Cyclophosphamide, (R)-isomer

Cyclophosphamide, (S)-isomer

Cyclophosphamides

Cyclophosphamidum

Cyclophosphamidum [INN-Latin]

Cyclophosphan

Cyclophosphane

Cyclophosphanum

Cyclophosphoramide

Cyclostin

Cyklofosfamid

Cyklofosfamid [Czech]

Cytophosphan

Cytophosphane

Cytoxan

Cytoxan (TN)

Cytoxan Lyoph

D,L-Cyclophosphamide

D07760

DB00531

DivK1c_000246

EINECS 200-015-4

Endoxan

Endoxan R

Endoxana

Endoxanal

Endoxan-Asta

Endoxane

Enduxan

EU-0100238

Genoxal

Hexadrin

HMS2090A12

HSDB 3047

IDI1_000246

KBio1_000246

KBio2_001338

KBio2_003906

KBio2_006474

KBio3_001319

KBioGR_000888

KBioSS_001338

Ledoxina

Lopac0_000238

Lopac-C-0768

LS-1302

LS-99787

Lyophilized Cytoxan

Mitoxan

MolPort-001-783-420

Monohydrate, cyclophosphamide

N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide

N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

NCGC00015209-01

NCGC00015209-03

NCGC00015209-06

NCGC00091741-02

NCGC00091741-03

NCI60_002097

NCI-C04900

Neosar

NINDS_000246

NSC 26271

NSC26271

NSC-26271

NSC273033

NSC273034

Occupation, cyclophosphamide exposure

Procytox

RCRA waste no. U058

Rcra waste number U058

Rcra Waste Number U058

Revimmune

S1217_Selleck

Semdoxan

Sendoxan

Senduxan

SK 20501

SPBio_001071

Spectrum_000858

Spectrum2_001146

Spectrum3_000370

Spectrum4_000304

Spectrum5_000795

STK177249

STOCK2S-91217

UNII-6UXW23996M

WLN: T6MPOTJ BO BN2G2G

Zyklophosphamid

Zyklophosphamid [German]

Doxil

Approved June 1999

Phase 2, Phase 3,Phase 1

31703

Isophosphamide mustard

Phase 2, Phase 3

Synonyms:

Ifosfamide mustard

Ifosforamide mustard

IPAM

Iphosphoramide mustard

Isophosphamide mustard

Isophosphoramide mustard

N,N'-di-(2-chloroethyl)phosphorodiamidic acid

NN'-Bis-(2-chloroethyl)phosphate

NN'-Bis-(2-chloroethyl)phosphoric acid

Palifosfamide-tris

zio-201Isophosphamide mustard

Alkylating Agents

Phase 2, Phase 3

Topoisomerase Inhibitors

Phase 2, Phase 3,Phase 1

Anti-Bacterial Agents

Phase 2, Phase 3,Phase 1

Antibiotics, Antitubercular

Phase 2, Phase 3,Phase 1

Antineoplastic Agents, Alkylating

Phase 2, Phase 3

razoxane

Phase 2

Protective Agents

Phase 2

Antimitotic Agents

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery	Recruiting	NCT02180867	Phase 2, Phase 3	Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
2	Alisertib in Treating Patients With Advanced or Metastatic Sarcoma	Completed	NCT01653028	Phase 2	Alisertib
3	Clinical and Biological Activity of an Anti-PD-L1 (Atezolizumab) in Operable Localised Soft Tissue Sarcomas Patients to be Treated With Radiotherapy	Recruiting	NCT03474094	Phase 2
4	Sapanisertib or Pazopanib Hydrochloride in Treating Patients With Locally Advanced or Metastatic Sarcoma	Recruiting	NCT02601209	Phase 1, Phase 2	Pazopanib Hydrochloride;Sapanisertib
5	Doxorubicin With Upfront Dexrazoxane Plus Olaratumab for the Treatment of Advanced or Metastatic Soft Tissue Sarcoma	Recruiting	NCT02584309	Phase 2	Dexrazoxane;Doxorubicin;Olaratumab
6	Ribociclib and Doxorubicin in Treating Patients With Metastatic or Advanced Soft Tissue Sarcomas That Cannot Be Removed by Surgery	Recruiting	NCT03009201	Phase 1	Doxorubicin;Ribociclib

Search NIH Clinical Center for Myxofibrosarcoma

Sources

Genetic Tests for Myxofibrosarcoma

Sources

Anatomical Context for Myxofibrosarcoma

MalaCards organs/tissues related to Myxofibrosarcoma:

⁴¹

Heart, Skin, Bone, Lung, Brain, Ovary, Prostate

Sources

Publications for Myxofibrosarcoma

Articles related to Myxofibrosarcoma:

(show top 50) (show all 205)

#	Title	Authors	Year
1	Myxofibrosarcoma of unusual sites. ( 29065228 )	Tjarks B.J....Billings S.D.	2018
2	Left atrial appendage myxofibrosarcoma: A rare masquerader of myxoma and thrombus-&quot;all that glitters is not gold&quot;. ( 29280521 )	Khan M.S....Biederman R.W.	2018
3	Primary cardiac myxofibrosarcoma: case report, literature review and pooled analysis. ( 29720127 )	Sun D....Yang J.	2018
4	Biology and Management of Undifferentiated Pleomorphic Sarcoma, Myxofibrosarcoma, and Malignant Peripheral Nerve Sheath Tumors: State of the Art and Perspectives. ( 29220302 )	Widemann B.C....Italiano A.	2018
5	Primary myxofibrosarcoma of the kidney. ( 29075931 )	Resorlu B....Germiyanoglu R.C.	2018
6	An entire clinical course of mediastinal myxofibrosarcoma treated by surgery and radiation. ( 29748938 )	Sugiura Y....Nemoto E.	2018
7	Successful management of a rare type of complex myxofibrosarcoma which affected right lung and invading into the left atrium under the guidance of multimode image. ( 29409129 )	Zhang H....Dong L.	2018
8	Pembrolizumab for Refractory Metastatic Myxofibrosarcoma: A Case Report. ( 29361819 )	Song H.N....Lee G.W.	2018
9	A rare presentation of myxofibrosarcoma as a Pancoast tumor: a case report. ( 28264709 )	Jevremovic V....Chedrawy E.G.	2017
10	Myxofibrosarcoma of the maxillary sinus. ( 28583233 )	Wong A....Eloy J.A.	2017
11	Metastatic high-grade myxofibrosarcoma: review of a clinical case. ( 28730250 )	Neagu T.P....Mirea L.E.	2017
12	Low-Grade Myxofibrosarcoma of the Rectus Abdominus Muscle Infiltrating into Abdominal Cavity: A Case Report. ( 28293331 )	Nomura T....Terashi H.	2017
13	Primary Cardiac High-grade Myxofibrosarcoma Presenting with Multiple Brain Metastases: A Case Report. ( 29375952 )	Badaloni F....Fioravanti A.	2017
14	High-grade myxofibrosarcoma of the abdominal wall. ( 28576911 )	Antbring R....Windsor A.C.	2017
15	Myxofibrosarcoma in Head and Neck: Case Report of Unusually Aggressive Presentation. ( 28893544 )	Quimby A....Fernandes R.	2017
16	Predictors of Local Recurrence in Patients With Myxofibrosarcoma. ( 28640064 )	Odei B....Kamrava M.	2017
17	Low grade myxofibrosarcoma in the right ventricle presenting as pulmonary thromboembolism. ( 29312771 )	Suh J.H....Park C.B.	2017
18	A histological positive margin after surgery is correlated with high local re-recurrence rate in patients with recurrent myxofibrosarcoma. ( 28064204 )	Kikuta K....Morioka H.	2017
19	Myxofibrosarcoma primary cultures: molecular and pharmacological profile. ( 29449896 )	De Vita A....Ibrahim T.	2017
20	Expanded molecular profiling of myxofibrosarcoma reveals potentially actionable targets. ( 28776571 )	Heitzer E....Liegl-Atzwanger B.	2017
21	Myxofibrosarcoma: First report of myxofibrosarcoma of bone arising at a bone infarct. ( 28429048 )	Kayser D....Chapin R.W.	2017
22	Discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2) is a novel biomarker of myxofibrosarcoma invasion identified by global protein expression profiling. ( 28668639 )	Kikuta K....Kondo T.	2017
23	Establishment of a novel cellular model for myxofibrosarcoma heterogeneity. ( 28304377 )	Lohberger B....Liegl-Atzwanger B.	2017
24	Distant metastasis in patients with myxofibrosarcoma. ( 28814152 )	Tsuchie H....Shimada Y.	2017
25	Claudin 6 expression is useful to distinguish myxofibrosarcomas from other myxoid soft tissue tumors. ( 28476380 )	Bekki H....Oda Y.	2017
26	Activity of anthracycline- and ifosfamide-based chemotherapy in a series of patients affected by advanced myxofibrosarcoma. ( 28852467 )	Colia V....Sanfilippo R.	2017
27	A Case of Myxofibrosarcoma in an Unusual Thoracic Location. ( 26933417 )	Gopalratnam K....Folman R.	2016
28	Myxofibrosarcoma of the extremity and trunk: a multidisciplinary approach leads to good local rates of LOCAL control. ( 27909132 )	Ghazala C.G....Gerrand C.H.	2016
29	Myxofibrosarcoma presenting as an exophytic, multi-lobed nodule on the leg. ( 27617600 )	Nielson C....Stone S.P.	2016
30	A case report of primary cardiac myxofibrosarcoma presenting with severe congestive heart failure. ( 27387491 )	Ujihira K....Ueda H.I.	2016
31	Primary cardiac myxofibrosarcoma in a young woman. ( 27594370 )	Becerra-MuA+oz V.M....RodrA-guez-Caulo E.	2016
32	Massively Distended Abdomen Caused by Fibromatosis Previously Misdiagnosed as Myxofibrosarcoma. ( 27858546 )	Kuhlen M....Borkhardt A.	2016
33	An unexpected skin ulcer and soft tissue necrosis after the nonconcurrent combination of proton beam therapy and pazopanib: A case of myxofibrosarcoma. ( 27523716 )	Uwa N....Sakagami M.	2016
34	Myxofibrosarcoma in the Thenar Eminence. ( 27505448 )	Martin-Smith J....Kelly E.J.	2016
35	Soft tissue myxofibrosarcoma: A clinico-pathological analysis of a series of 75 patients with emphasis on the epithelioid variant. ( 27076198 )	Scoccianti G....Franchi A.	2016
36	Giant myxofibrosarcoma of the orbit: a rare case and a review of the literature. ( 27298287 )	Meel R....Sharma S.	2016
37	Modified partial maxillary swing approach for myxofibrosarcoma in pterygopalatine fossa. ( 27501198 )	Shimoda H....Nibu K.I.	2016
38	Tail of Superficial Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma After Preoperative Radiotherapy. ( 27127141 )	Imanishi J....Choong P.F.	2016
39	Integrin-I+10 Dependency Identifies RAC and RICTOR as Therapeutic Targets in High-Grade Myxofibrosarcoma. ( 27577794 )	Okada T....Singer S.	2016
40	Myxofibrosarcoma of the heart: A case report with positive pleural effusion cytology. ( 27546198 )	Hagiwara Y....Yuba Y.	2016
41	Surgical margins do not affect prognosis in high grade myxofibrosarcoma. ( 27260849 )	Sambri A....Donati D.	2016
42	Myxofibrosarcoma. ( 27591498 )	Roland C.L....Torres K.E.	2016
43	Optimal Percent Myxoid Component to Predict Outcome in High-Grade Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma. ( 26759307 )	Lee A.Y....Singer S.	2016
44	Right cardiac intracavitary metastases from a primary intracranial myxofibrosarcoma. ( 27013654 )	Costa D.A....Mafra M.	2016
45	Myxofibrosarcoma - Case report. ( 26982788 )	Castro B.A....Miranda R.M.	2016
46	Coronary thrombus aspiration revealed tumorous embolism of myxofibrosarcoma from the left atrium. ( 25711731 )	Noguchi M....Ako J.	2015
47	Primary renal myxofibrosarcoma. ( 26008776 )	Val-Bernal J.F....Jorge-PAcrez N.	2015
48	Intramuscular high-grade myxofibrosarcoma of left buttock of 66-year-old male patient - approach to systematic histopathological reporting. ( 26743304 )	Wincewicz A....Sulkowski S.	2015
49	High-grade myxofibrosarcoma-presented as a large mass of right upper arm. ( 25673608 )	Jagtap S.V....Kshirsagar A.Y.	2015
50	Cell cycle and apoptosis regulatory proteins, proliferative markers, cell signaling molecules, CD209, and decorin immunoreactivity in low-grade myxofibrosarcoma and myxoma. ( 25940995 )	Cates J.M....Gonzalez R.S.	2015

Sources

Genes for Myxofibrosarcoma

Genes related to Myxofibrosarcoma (3 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CREB3L1	CAMP Responsive Element Binding Protein 3 Like 1	Protein Coding	350	Gene fusion ⁵⁹
2	FUS	FUS RNA Binding Protein	Protein Coding	350	Gene fusion ⁵⁹
3	CREB3L2	CAMP Responsive Element Binding Protein 3 Like 2	Protein Coding	350	Gene fusion ⁵⁹
4	DES	Desmin	Protein Coding	17.09	GeneCards inferred via : Publications (show sections)
5	S100B	S100 Calcium Binding Protein B	Protein Coding	17.09	GeneCards inferred via : Publications (show sections)
6	MKI67	Marker Of Proliferation Ki-67	Protein Coding	16.89	GeneCards inferred via : Publications (show sections)
7	CCNA2	Cyclin A2	Protein Coding	16.89	GeneCards inferred via : Publications (show sections)
8	CD36	CD36 Molecule	Protein Coding	16.89	GeneCards inferred via : Publications (show sections)
9	THBS1	Thrombospondin 1	Protein Coding	16.54	GeneCards inferred via : Publications (show sections)

Sources

Variations for Myxofibrosarcoma

Copy number variations for Myxofibrosarcoma from CNVD:

⁷ (show all 47)

#	CNVD ID	Chromosom	Start	End	Type	Gene Symbol	CNVD Disease
1	29705	1	234600000	241700000	Loss	AKT3	Myxofibrosarcoma
2	38875	10	105700000	114900000	Loss	FACL5	Myxofibrosarcoma
3	39423	10	114900000	127400000	Loss	DMBT1	Myxofibrosarcoma
4	42687	10	3800000	6700000	Loss	DNMT2	Myxofibrosarcoma
5	47803	10	98000000	105700000	Loss	HOX11	Myxofibrosarcoma
6	47805	10	98000000	105700000	Loss	PLAU	Myxofibrosarcoma
7	49687	11	110000000	120700000	Loss	PIG8	Myxofibrosarcoma
8	51757	11	130300000	134452384	Loss	ADAMTS8	Myxofibrosarcoma
9	54382	11	43400000	48800000	Loss	KAI1	Myxofibrosarcoma
10	61474	12	1	14800000	Gain	CCND2	Myxofibrosarcoma
11	61522	12	1	33200000	Loss	LRP6	Myxofibrosarcoma
12	66186	12	26300000	33200000	Gain	KRAG	Myxofibrosarcoma
13	70913	12	66000000	69800000	Gain	HMGIC	Myxofibrosarcoma
14	73112	12	91200000	94800000	Loss	BTG1	Myxofibrosarcoma
15	108897	17	23200000	35400000	Loss	LIG3	Myxofibrosarcoma
16	115128	17	54900000	59900000	Gain	TBX2	Myxofibrosarcoma
17	124176	19	1	6900000	Gain	SH3GL1	Myxofibrosarcoma
18	143681	2	23900000	31900000	Loss	ALK	Myxofibrosarcoma
19	147727	2	69800000	136600000	Loss	CXCR4	Myxofibrosarcoma
20	148303	2	75400000	83700000	Loss	REG1A	Myxofibrosarcoma
21	151117	20	17800000	27100000	Loss	JAG1	Myxofibrosarcoma
22	170894	3	161200000	184200000	Loss	MDS1	Myxofibrosarcoma
23	177567	3	58500000	63700000	Loss	FHIT	Myxofibrosarcoma
24	186568	4	36900000	114100000	Loss	IBSP	Myxofibrosarcoma
25	187541	4	50700000	52400000	Gain	AFP	Myxofibrosarcoma
26	208064	6	164400000	170899992	Loss	PDCD2	Myxofibrosarcoma
27	217848	7	104755715	105039798	Amplificationlication	SRPK2	Myxofibrosarcoma
28	217923	7	105888733	105925638	Amplificationlication	PBEF1	Myxofibrosarcoma
29	218114	7	107788083	108096826	Amplificationlication	NRCAM	Myxofibrosarcoma
30	218692	7	116312458	116438439	Amplificationlication	MET	Myxofibrosarcoma
31	219052	7	121513158	121702088	Amplificationlication	PTPRZ1	Myxofibrosarcoma
32	219257	7	124462440	124570037	Amplificationlication	POT1	Myxofibrosarcoma
33	219480	7	127292201	127732658	Amplificationlication	SND1	Myxofibrosarcoma
34	219953	7	132400000	147500000	Gain	TIM1	Myxofibrosarcoma
35	223288	7	1855427	2272583	Amplificationlicatio n	MAD1L1	Myxofibrosarcoma
36	225548	7	47314752	47621742	Amplification	TNS3	Myxofibrosarcoma
37	228044	7	73245192	73247014	Amplificationlicatio n	CLDN4	Myxofibrosarcoma
38	228772	7	81331444	81399452	Amplificationlicatio n	HGF	Myxofibrosarcoma
39	229104	7	87257728	87461612	Amplificationlicatio n	RPIP9	Myxofibrosarcoma
40	229332	7	90095737	90839904	Amplificationlicatio n	PFTK1	Myxofibrosarcoma
41	229600	7	92234236	92465941	Amplificationlicatio n	CDK6	Myxofibrosarcoma
42	234953	8	140000000	146274826	Gain	TG	Myxofibrosarcoma
43	242385	8	7200000	43200000	Gain	POLB	Myxofibrosarcoma
44	262150	X	31500000	37500000	Gain	OTC	Myxofibrosarcoma
45	264432	X	65100000	67700000	Gain	ED1	Myxofibrosarcoma
46	264546	X	67700000	72200000	Gain	TED	Myxofibrosarcoma
47	266520	X	98200000	110500000	Loss	PLP	Myxofibrosarcoma

Sources

Expression for Myxofibrosarcoma

Search GEO for disease gene expression data for Myxofibrosarcoma.

Sources

Pathways for Myxofibrosarcoma

Pathways related to Myxofibrosarcoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	12.38	CCNA2 CREB3L1 CREB3L2 THBS1
2	Kaposi's sarcoma-associated herpesvirus infection ³⁷ Show member pathways Hepatitis B ³⁷	12.1	CCNA2 CREB3L1 CREB3L2
3	Viral carcinogenesis ³⁷	11.64	CCNA2 CREB3L1 CREB3L2
4	AMP-activated Protein Kinase (AMPK) Signaling ¹ Show member pathways AMPK signaling pathway ³⁷ AMPK Signaling Pathway ⁶⁷	11.34	CCNA2 CD36 CREB3L1 CREB3L2
5	P38 MAPK Signaling Pathway (sino) ⁶⁷	11.23	CREB3L1 CREB3L2
6	Insulin resistance ³⁷ Show member pathways protein O-[N-acetyl]-glucosylation ¹	11.17	CD36 CREB3L1 CREB3L2
7	Malaria ³⁷	11.06	CD36 THBS1
8	Vasopressin-regulated water reabsorption ³⁷	10.97	CREB3L1 CREB3L2

Sources

GO Terms for Myxofibrosarcoma

Biological processes related to Myxofibrosarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endoplasmic reticulum unfolded protein response	GO:0030968	9.37	CREB3L1 CREB3L2
2	negative regulation of sprouting angiogenesis	GO:1903671	9.32	CREB3L1 THBS1
3	positive regulation of reactive oxygen species metabolic process	GO:2000379	9.26	CD36 THBS1
4	negative regulation of fibroblast growth factor receptor signaling pathway	GO:0040037	9.16	CREB3L1 THBS1
5	positive regulation of blood coagulation	GO:0030194	8.96	CD36 THBS1
6	response to unfolded protein	GO:0006986	8.8	CREB3L1 CREB3L2 THBS1

Molecular functions related to Myxofibrosarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transforming growth factor beta binding	GO:0050431	9.16	CD36 THBS1
2	low-density lipoprotein particle binding	GO:0030169	8.96	CD36 THBS1
3	cAMP response element binding	GO:0035497	8.62	CREB3L1 CREB3L2

Sources

Sources for Myxofibrosarcoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia