MCID: MYX013
MIFTS: 34

Myxofibrosarcoma

Categories: Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Myxofibrosarcoma

MalaCards integrated aliases for Myxofibrosarcoma:

Name: Myxofibrosarcoma 60
Fibromyxosarcoma 60 74
Dermatofibrosarcoma Protuberans, Myxoid 74
Myxoid Malignant Fibrous Histiocytoma 60

Characteristics:

Orphanet epidemiological data:

60
myxofibrosarcoma
Inheritance: Not applicable; Age of onset: Adult;

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 35 C49.9
UMLS via Orphanet 75 C3714524
Orphanet 60 ORPHA79105

Summaries for Myxofibrosarcoma

MalaCards based summary : Myxofibrosarcoma, also known as fibromyxosarcoma, is related to pleomorphic liposarcoma and spindle cell sarcoma. An important gene associated with Myxofibrosarcoma is FUS (FUS RNA Binding Protein), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Viral carcinogenesis. Affiliated tissues include prostate, skin and brain.

Wikipedia : 77 A histiocytoma is a tumour consisting of histiocytes. Histiocytes are cells that are a part of the... more...

Related Diseases for Myxofibrosarcoma

Diseases related to Myxofibrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 pleomorphic liposarcoma 30.7 DES S100B
2 spindle cell sarcoma 30.6 DES S100B
3 liposarcoma 30.5 DES FUS
4 malignant fibroxanthoma 30.3 DES MKI67 S100B
5 fibrous histiocytoma 30.2 DES FUS S100B
6 dermatofibrosarcoma protuberans 30.0 DES S100B
7 embryonal sarcoma 30.0 DES MKI67 S100B
8 sarcoma 10.4
9 undifferentiated pleomorphic sarcoma 10.4
10 malignant triton tumor 10.3 DES S100B
11 syringocystadenoma papilliferum 10.3 DES S100B
12 ossifying fibromyxoid tumor 10.3 DES S100B
13 spindle cell rhabdomyosarcoma 10.3 DES S100B
14 syringoma 10.3 DES S100B
15 juvenile xanthogranuloma 10.3 DES S100B
16 cutaneous fibrous histiocytoma 10.3 DES S100B
17 granular cell tumor 10.3 DES S100B
18 doxorubicin induced cardiomyopathy 10.3 DES MET
19 hemangiopericytoma, malignant 10.3 DES S100B
20 odontogenic myxoma 10.2 CD36 S100B
21 spinal chordoma 10.2 MET S100B
22 pulmonary vein stenosis 10.2 DES MKI67
23 adenosarcoma 10.2 DES MKI67
24 hidradenocarcinoma 10.2 MKI67 S100B
25 polymorphous low-grade adenocarcinoma 10.2 MKI67 S100B
26 neurilemmoma 10.2 DES S100B
27 pilomatrixoma 10.2 CD36 S100B
28 osteofibrous dysplasia 10.2 CD36 MET
29 papillary thyroid microcarcinoma 10.2 MET MKI67
30 meningioma, radiation-induced 10.2 MKI67 S100B
31 papular mucinosis 10.2
32 retroperitoneal liposarcoma 10.2
33 myxoid liposarcoma 10.1
34 histiocytoma 10.1
35 extraskeletal ewing sarcoma 10.1 DES FUS
36 inflammatory myofibroblastic tumor 10.1 DES S100B
37 cavernous hemangioma 10.1 DES MKI67
38 chordoma 10.1 DES MET S100B
39 alveolar soft part sarcoma 10.1 DES MET
40 ependymoma 10.1 MKI67 S100B
41 lipomatosis, multiple 10.1 DES FUS
42 burn scar 10.1
43 osteogenesis imperfecta, type iii 10.1 CD36 CREB3L1
44 gastrointestinal stromal tumor 10.0 DES MKI67 S100B
45 thrombocytopenia 10.0
46 adenocarcinoma 10.0
47 polycythemia 10.0
48 glioma 10.0
49 syncope 10.0
50 clear cell sarcoma 10.0 FUS S100B

Graphical network of the top 20 diseases related to Myxofibrosarcoma:



Diseases related to Myxofibrosarcoma

Symptoms & Phenotypes for Myxofibrosarcoma

Drugs & Therapeutics for Myxofibrosarcoma

Search Clinical Trials , NIH Clinical Center for Myxofibrosarcoma

Genetic Tests for Myxofibrosarcoma

Anatomical Context for Myxofibrosarcoma

MalaCards organs/tissues related to Myxofibrosarcoma:

42
Prostate, Skin, Brain, Bone, Uterus, Thyroid, Trachea

Publications for Myxofibrosarcoma

Articles related to Myxofibrosarcoma:

(show top 50) (show all 242)
# Title Authors Year
1
Upper extremity myxofibrosarcoma mimicking an erosive inflammatory arthritis: a case report. ( 30989248 )
2019
2
Immunotherapy for advanced lung cancer combined with surgery for mediastinal myxofibrosarcoma: a case report. ( 30806844 )
2019
3
Emergency Ross Procedure for Pediatric Aortic Valve Myxofibrosarcoma. ( 30266618 )
2019
4
Establishment and characterization of a novel cell line, NCC-MFS1-C1, derived from a patient with myxofibrosarcoma. ( 30737712 )
2019
5
Aggressive invasive recurrence of a right atrial myxofibrosarcoma. ( 30851052 )
2019
6
Palliative Surgical Resection of an Extensive Metastatic Cardiac Myxofibrosarcoma. ( 30967750 )
2019
7
MAGE-A3 is a Clinically Relevant Target in Undifferentiated Pleomorphic Sarcoma/Myxofibrosarcoma. ( 31096717 )
2019
8
Does pre-operative MRI predict the risk of local recurrence in primary myxofibrosarcoma of the extremities? ( 31111597 )
2019
9
Predictors of Local Recurrence in Patients With Myxofibrosarcoma. ( 28640064 )
2018
10
Myxofibrosarcoma of unusual sites. ( 29065228 )
2018
11
Primary myxofibrosarcoma of the kidney. ( 29075931 )
2018
12
Biology and Management of Undifferentiated Pleomorphic Sarcoma, Myxofibrosarcoma, and Malignant Peripheral Nerve Sheath Tumors: State of the Art and Perspectives. ( 29220302 )
2018
13
Left atrial appendage myxofibrosarcoma: A rare masquerader of myxoma and thrombus-"all that glitters is not gold". ( 29280521 )
2018
14
Pembrolizumab for Refractory Metastatic Myxofibrosarcoma: A Case Report. ( 29361819 )
2018
15
Successful management of a rare type of complex myxofibrosarcoma which affected right lung and invading into the left atrium under the guidance of multimode image. ( 29409129 )
2018
16
Primary cardiac myxofibrosarcoma: case report, literature review and pooled analysis. ( 29720127 )
2018
17
An entire clinical course of mediastinal myxofibrosarcoma treated by surgery and radiation. ( 29748938 )
2018
18
Integrated genetic and epigenetic analysis of myxofibrosarcoma. ( 30018380 )
2018
19
Prognostic significance of microscopic tumor extension in local recurrence of myxofibrosarcoma and undifferentiated pleomorphic sarcoma. ( 30094896 )
2018
20
MET-overexpressing myxofibrosarcoma frequently exhibit polysomy of chromosome 7 but not MET amplification, especially in high-grade cases: clinical and pathological review of 30 myxofibrosarcoma cases. ( 30126419 )
2018
21
Epithelioid myxofibrosarcoma developing at the injection site of Adalimumab therapy for psoriatic synovitis. ( 30185362 )
2018
22
Orbital Myxofibrosarcoma: Case Report and Review of Literature. ( 30204636 )
2018
23
Acute Trauma Precipitating the Onset of Chest Wall Myxofibrosarcoma. ( 30288009 )
2018
24
A combination of irinotecan/cisplatinum and irinotecan/temozolomide or tumor-targeting Salmonella typhimurium A1-R arrest doxorubicin- and temozolomide-resistant myxofibrosarcoma in a PDOX mouse model. ( 30292411 )
2018
25
Characterization and Drug Sensitivity of a New High-Grade Myxofibrosarcoma Cell Line. ( 30366467 )
2018
26
PROGNOSTIC FACTORS IN PATIENTS WITH APPENDICULAR MYXOFIBROSARCOMA. ( 30464713 )
2018
27
A histological positive margin after surgery is correlated with high local re-recurrence rate in patients with recurrent myxofibrosarcoma. ( 28064204 )
2017
28
A rare presentation of myxofibrosarcoma as a Pancoast tumor: a case report. ( 28264709 )
2017
29
Low-Grade Myxofibrosarcoma of the Rectus Abdominus Muscle Infiltrating into Abdominal Cavity: A Case Report. ( 28293331 )
2017
30
Establishment of a novel cellular model for myxofibrosarcoma heterogeneity. ( 28304377 )
2017
31
Myxofibrosarcoma: First report of myxofibrosarcoma of bone arising at a bone infarct. ( 28429048 )
2017
32
High-grade myxofibrosarcoma of the abdominal wall. ( 28576911 )
2017
33
Myxofibrosarcoma of the maxillary sinus. ( 28583233 )
2017
34
Discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2) is a novel biomarker of myxofibrosarcoma invasion identified by global protein expression profiling. ( 28668639 )
2017
35
Metastatic high-grade myxofibrosarcoma: review of a clinical case. ( 28730250 )
2017
36
Expanded molecular profiling of myxofibrosarcoma reveals potentially actionable targets. ( 28776571 )
2017
37
Distant metastasis in patients with myxofibrosarcoma. ( 28814152 )
2017
38
Activity of anthracycline- and ifosfamide-based chemotherapy in a series of patients affected by advanced myxofibrosarcoma. ( 28852467 )
2017
39
Myxofibrosarcoma in Head and Neck: Case Report of Unusually Aggressive Presentation. ( 28893544 )
2017
40
Low grade myxofibrosarcoma in the right ventricle presenting as pulmonary thromboembolism. ( 29312771 )
2017
41
Primary Cardiac High-grade Myxofibrosarcoma Presenting with Multiple Brain Metastases: A Case Report. ( 29375952 )
2017
42
Myxofibrosarcoma primary cultures: molecular and pharmacological profile. ( 29449896 )
2017
43
Myxofibrosarcoma in the Thenar Eminence. ( 27505448 )
2017
44
An unexpected skin ulcer and soft tissue necrosis after the nonconcurrent combination of proton beam therapy and pazopanib: A case of myxofibrosarcoma. ( 27523716 )
2017
45
Primary atrial fibromyxosarcoma with multiple-system metastases: A case report. ( 29245258 )
2017
46
A case report of primary cardiac myxofibrosarcoma presenting with severe congestive heart failure. ( 27387491 )
2016
47
Massively Distended Abdomen Caused by Fibromatosis Previously Misdiagnosed as Myxofibrosarcoma. ( 27858546 )
2016
48
Myxofibrosarcoma presenting as an exophytic, multi-lobed nodule on the leg. ( 27617600 )
2016
49
Myxofibrosarcoma of the extremity and trunk: a multidisciplinary approach leads to good local rates of LOCAL control. ( 27909132 )
2016
50
Coronary thrombus aspiration revealed tumorous embolism of myxofibrosarcoma from the left atrium. ( 25711731 )
2016

Variations for Myxofibrosarcoma

Copy number variations for Myxofibrosarcoma from CNVD:

7 (show all 47)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 29705 1 234600000 241700000 Loss AKT3 Myxofibrosarcoma
2 38875 10 105700000 114900000 Loss FACL5 Myxofibrosarcoma
3 39423 10 114900000 127400000 Loss DMBT1 Myxofibrosarcoma
4 42687 10 3800000 6700000 Loss DNMT2 Myxofibrosarcoma
5 47803 10 98000000 105700000 Loss HOX11 Myxofibrosarcoma
6 47805 10 98000000 105700000 Loss PLAU Myxofibrosarcoma
7 49687 11 110000000 120700000 Loss PIG8 Myxofibrosarcoma
8 51757 11 130300000 134452384 Loss ADAMTS8 Myxofibrosarcoma
9 54382 11 43400000 48800000 Loss KAI1 Myxofibrosarcoma
10 61474 12 1 14800000 Gain CCND2 Myxofibrosarcoma
11 61522 12 1 33200000 Loss LRP6 Myxofibrosarcoma
12 66186 12 26300000 33200000 Gain KRAG Myxofibrosarcoma
13 70913 12 66000000 69800000 Gain HMGIC Myxofibrosarcoma
14 73112 12 91200000 94800000 Loss BTG1 Myxofibrosarcoma
15 108897 17 23200000 35400000 Loss LIG3 Myxofibrosarcoma
16 115128 17 54900000 59900000 Gain TBX2 Myxofibrosarcoma
17 124176 19 1 6900000 Gain SH3GL1 Myxofibrosarcoma
18 143681 2 23900000 31900000 Loss ALK Myxofibrosarcoma
19 147727 2 69800000 136600000 Loss CXCR4 Myxofibrosarcoma
20 148303 2 75400000 83700000 Loss REG1A Myxofibrosarcoma
21 151117 20 17800000 27100000 Loss JAG1 Myxofibrosarcoma
22 170894 3 161200000 184200000 Loss MDS1 Myxofibrosarcoma
23 177567 3 58500000 63700000 Loss FHIT Myxofibrosarcoma
24 186568 4 36900000 114100000 Loss IBSP Myxofibrosarcoma
25 187541 4 50700000 52400000 Gain AFP Myxofibrosarcoma
26 208064 6 164400000 170899992 Loss PDCD2 Myxofibrosarcoma
27 217848 7 104755715 105039798 Amplificationlication SRPK2 Myxofibrosarcoma
28 217923 7 105888733 105925638 Amplificationlication PBEF1 Myxofibrosarcoma
29 218114 7 107788083 108096826 Amplificationlication NRCAM Myxofibrosarcoma
30 218692 7 116312458 116438439 Amplificationlication MET Myxofibrosarcoma
31 219052 7 121513158 121702088 Amplificationlication PTPRZ1 Myxofibrosarcoma
32 219257 7 124462440 124570037 Amplificationlication POT1 Myxofibrosarcoma
33 219480 7 127292201 127732658 Amplificationlication SND1 Myxofibrosarcoma
34 219953 7 132400000 147500000 Gain TIM1 Myxofibrosarcoma
35 223288 7 1855427 2272583 Amplificationlicatio n MAD1L1 Myxofibrosarcoma
36 225548 7 47314752 47621742 Amplification TNS3 Myxofibrosarcoma
37 228044 7 73245192 73247014 Amplificationlicatio n CLDN4 Myxofibrosarcoma
38 228772 7 81331444 81399452 Amplificationlicatio n HGF Myxofibrosarcoma
39 229104 7 87257728 87461612 Amplificationlicatio n RPIP9 Myxofibrosarcoma
40 229332 7 90095737 90839904 Amplificationlicatio n PFTK1 Myxofibrosarcoma
41 229600 7 92234236 92465941 Amplificationlicatio n CDK6 Myxofibrosarcoma
42 234953 8 140000000 146274826 Gain TG Myxofibrosarcoma
43 242385 8 7200000 43200000 Gain POLB Myxofibrosarcoma
44 262150 X 31500000 37500000 Gain OTC Myxofibrosarcoma
45 264432 X 65100000 67700000 Gain ED1 Myxofibrosarcoma
46 264546 X 67700000 72200000 Gain TED Myxofibrosarcoma
47 266520 X 98200000 110500000 Loss PLP Myxofibrosarcoma

Expression for Myxofibrosarcoma

Search GEO for disease gene expression data for Myxofibrosarcoma.

Pathways for Myxofibrosarcoma

GO Terms for Myxofibrosarcoma

Biological processes related to Myxofibrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.33 MET MKI67 S100B
2 endoplasmic reticulum unfolded protein response GO:0030968 8.96 CREB3L1 CREB3L2
3 regulation of mitotic nuclear division GO:0007088 8.62 CCNA2 MKI67

Molecular functions related to Myxofibrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cAMP response element binding GO:0035497 8.62 CREB3L1 CREB3L2

Sources for Myxofibrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....