MCID: MYX008
MIFTS: 32

Myxoid Chondrosarcoma

Categories: Cancer diseases

Aliases & Classifications for Myxoid Chondrosarcoma

MalaCards integrated aliases for Myxoid Chondrosarcoma:

Name: Myxoid Chondrosarcoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5861
NCIt 49 C4303
SNOMED-CT 67 75622000
UMLS 71 C0334551

Summaries for Myxoid Chondrosarcoma

MalaCards based summary : Myxoid Chondrosarcoma is related to chondrosarcoma, extraskeletal myxoid and extraosseous chondrosarcoma. An important gene associated with Myxoid Chondrosarcoma is EWSR1 (EWS RNA Binding Protein 1), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Mecasermin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and brain.

Wikipedia : 74 Myxoid chondrosarcoma is a type of... more...

Related Diseases for Myxoid Chondrosarcoma

Diseases in the Myxoid Chondrosarcoma family:

Adult Myxoid Chondrosarcoma

Diseases related to Myxoid Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 258)
# Related Disease Score Top Affiliating Genes
1 chondrosarcoma, extraskeletal myxoid 32.3 TFG TAF15 SYP SMARCB1 NR4A3 GFAP
2 extraosseous chondrosarcoma 31.9 TFG TAF15 SYP SMARCB1 NR4A3 EWSR1
3 liposarcoma 30.9 TAF15 EWSR1 CD68
4 chondrosarcoma 30.9 TFG TAF15 S100B NR4A3 MUC1 MTAP
5 parachordoma 30.7 MUC1 GFAP
6 clear cell sarcoma 30.6 SYP S100B EWSR1
7 ossifying fibromyxoid tumor 30.5 S100B MUC1
8 ewing sarcoma 30.1 TAF15 SYP S100B NR4A3 EWSR1
9 rhabdoid cancer 30.1 SYP SMARCB1 EWSR1
10 rhabdoid tumor predisposition syndrome 1 30.1 SYP SMARCB1 MUC1
11 histiocytoma 30.1 MTAP EWSR1 CD68
12 pleomorphic adenoma 30.0 S100B MUC1 GFAP
13 sarcoma, synovial 30.0 SMARCB1 S100B MUC1 EWSR1
14 sarcoma 29.9 SMARCB1 S100B NR4A3 MUC1 MTAP EWSR1
15 chordoma 29.8 SMARCB1 S100B MUC1 MTAP GFAP
16 mesenchymal chondrosarcoma 29.8 SYP SMARCB1 MUC1 GFAP
17 fibrous histiocytoma 29.7 S100B MTAP EWSR1 CD68
18 chordoid meningioma 29.6 SYP S100B MUC1 GFAP
19 meningioma, radiation-induced 29.6 SMARCB1 S100B MUC1 GFAP
20 neurilemmoma 29.4 SMARCB1 S100B MUC1 GFAP
21 myoepithelioma 29.3 SMARCB1 S100B MUC1 GFAP EWSR1
22 myoepithelial carcinoma 29.2 SMARCB1 NR4A3 MUC1 GFAP EWSR1
23 hydrocephalus 28.9 SYP SMARCB1 S100B MAPT GFAP
24 meningioma, familial 28.7 SYP SMARCB1 GFAP CDKN2B CD68
25 adult myxoid chondrosarcoma 12.7
26 pediatric myxoid chondrosarcoma 12.5
27 soft tissue sarcoma 10.7
28 rare tumor 10.7
29 spindle cell sarcoma 10.5
30 rare soft tissue tumor 10.5
31 bone chondrosarcoma 10.5 TAF15 NR4A3
32 extraskeletal mesenchymal chondrosarcoma 10.5 TAF15 EWSR1
33 myxoid liposarcoma 10.4
34 sclerosing perineurioma 10.4 S100B MUC1
35 localized hypertrophic neuropathy 10.4 S100B MUC1
36 reticular perineurioma 10.4 S100B MUC1
37 non-functioning pituitary adenoma 10.4 S100B MUC1
38 aggressive digital papillary adenocarcinoma 10.4 S100B MUC1
39 eccrine porocarcinoma 10.4 S100B MUC1
40 desmoplastic small round cell tumor 10.4 MUC1 EWSR1
41 meningeal melanocytoma 10.4 S100B MUC1
42 biphasic synovial sarcoma 10.4 MUC1 EWSR1
43 intraneural perineurioma 10.4 S100B MUC1
44 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.4 SYP EWSR1
45 cauda equina neoplasm 10.4 SYP EWSR1
46 akinetic mutism 10.4 S100B MAPT
47 sinonasal undifferentiated carcinoma 10.3 SYP MUC1
48 papillary tumor of the pineal region 10.3 SYP MUC1
49 vulvar eccrine porocarcinoma 10.3 SYP MUC1
50 cervical neuroblastoma 10.3 SYP EWSR1

Graphical network of the top 20 diseases related to Myxoid Chondrosarcoma:



Diseases related to Myxoid Chondrosarcoma

Symptoms & Phenotypes for Myxoid Chondrosarcoma

Drugs & Therapeutics for Myxoid Chondrosarcoma

Drugs for Myxoid Chondrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mecasermin Approved, Investigational Phase 2 68562-41-4
2
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
3
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
4
Everolimus Approved Phase 2 159351-69-6 6442177 70789204
5
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
6 Antibodies, Monoclonal Phase 2
7 Mitogens Phase 2
8 Immunoglobulins Phase 2
9 Antibodies Phase 2
10 insulin Phase 2
11 Insulin, Globin Zinc Phase 2
12 lysine Phase 2
13 Alkylating Agents Phase 2
14 Antirheumatic Agents Phase 2
15 Anti-Infective Agents Phase 2
16 Antibiotics, Antitubercular Phase 2
17 Anti-Bacterial Agents Phase 2
18 Antifungal Agents Phase 2
19 Immunosuppressive Agents Phase 2
20 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Trial of R1507, a Recombinant Human Monoclonal Antibody to the Insulin-Like Growth Factor-1 Receptor for the Treatment of Participants With Recurrent or Refractory Ewing's Sarcoma, Osteosarcoma, Synovial Sarcoma, Rhabdomyosarcoma and Other Sarcomas. Completed NCT00642941 Phase 2 RG1507
2 A Phase 2, Single Arm, Multi Center Trial Evaluating the Efficacy of the COmbination of Sirolimus and cYclophosphamide in Metastatic or Unresectable Myxoid Liposarcoma and chOndrosarcoma Recruiting NCT02821507 Phase 2 sirolimus and cyclophosphamide
3 A Phase II, Multicenter Study of the EZH2 Inhibitor Tazemetostat in Adult Subjects With INI1-Negative Tumors or Relapsed/Refractory Synovial Sarcoma Recruiting NCT02601950 Phase 2 Tazemetostat
4 A Phase II Open-Label Trial of Pazopanib Administered as a Single Agent in Patients With Unresectable or Metastatic Solitary Fibrous Tumor (SFT) and Extraskeletal Myxoid Chondrosarcoma (EMC) Active, not recruiting NCT02066285 Phase 2 Pazopanib
5 A Randomized Prospective, Multicentric, Open Label, Phase II Study Aiming to Evaluate the Efficacity and Safety of EVEROLIMUS as Neo-adjuvant Therapy in Patients With Primary or Relapsed Chondrosarcomas Suspended NCT02008019 Phase 2 Everolimus 2.5 mg/day;Everolimus 10 mg/day
6 A Phase 1 Study of the EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma Recruiting NCT02601937 Phase 1 Tazemetostat
7 Observational Study, for Quality Assessment, of Sarcoma as a Model to Improve Diagnosis and Clinical Care of Rare Tumors Through a European and Latin American Multidisciplinary NETWORK Recruiting NCT04181970

Search NIH Clinical Center for Myxoid Chondrosarcoma

Genetic Tests for Myxoid Chondrosarcoma

Anatomical Context for Myxoid Chondrosarcoma

MalaCards organs/tissues related to Myxoid Chondrosarcoma:

40
Bone, Lung, Brain, Breast, Pituitary, Cerebellum, Heart

Publications for Myxoid Chondrosarcoma

Articles related to Myxoid Chondrosarcoma:

(show top 50) (show all 456)
# Title Authors PMID Year
1
The Extracompartmental Tumoral Invasion of Extraskeletal Myxoid Chondrosarcoma Induces Distant Metastasis. 61
32014950 2020
2
[Clinical analysis of sinonasal chondrosarcoma in 47 cases]. 61
31954383 2020
3
Results of a prospective phase 2 study of pazopanib in patients with surgically unresectable or metastatic chondrosarcoma. 61
31509242 2020
4
Extraskeletal Myxoid Chondrosarcoma of the Midfoot Presenting as Charcot Arthropathy: A Case Report. 61
31589174 2019
5
NR4A3 Immunohistochemistry Lacks Sensitivity for the Diagnosis of Extraskeletal Myxoid Chondrosarcoma. 61
31414988 2019
6
A rare case of chondrosarcoma arising in parotid with extension to lateral skull base. 61
31796459 2019
7
A renal cell carcinoma with EWSR1-TFE3 fusion gene. 61
31774608 2019
8
Pazopanib for treatment of advanced extraskeletal myxoid chondrosarcoma: a multicentre, single-arm, phase 2 trial. 61
31331701 2019
9
NR4A3 fusion proteins trigger an axon guidance switch that marks the difference between EWSR1 and TAF15 translocated extraskeletal myxoid chondrosarcomas. 61
31020999 2019
10
EWSR1-NFATC2 Translocation-associated Sarcoma Clinicopathologic Findings in a Rare Aggressive Primary Bone or Soft Tissue Tumor. 61
30994538 2019
11
Extraskeletal Myxoid Chondrosarcoma of the Parotid Gland. 61
31909032 2019
12
Huge myxoid chondrosarcoma expanded into the thoracic cavity with spinal involvement. 61
29974237 2019
13
A 5-year follow-up of vulval swelling due to extraskeletal myxoid chondrosarcoma: A rare case report. 61
30967942 2019
14
Extraskeletal myxoid chondrosarcoma of the leg in a child: A case report. 61
30985717 2019
15
A rare manifestation of extraskeletal myxoid chondrosarcoma with a huge expanding hematoma. 61
28187993 2019
16
[Chondromucinous tumors involving craniocerebral slope area: a clinicopathological analysis of eight cases]. 61
30831645 2019
17
Intraluminal EWSR1-CREB1 gene rearranged, low-grade myxoid sarcoma of the pulmonary artery resembling extraskeletal myxoid chondrosarcoma (EMC). 61
30326150 2019
18
Efficacy and Safety of Nanosomal Docetaxel Lipid Suspension-Based Chemotherapy in Sarcoma: A Multicenter, Retrospective Study. 61
31827370 2019
19
Ewing's sarcoma/peripheral primitive neuroectodermal tumor with extraskeletal myxoid chondrosarcoma-like areas: a case report. 61
31933786 2019
20
Fine-needle aspiration features of extraskeletal myxoid chondrosarcoma: A study of cytological and molecular features. 61
30353688 2018
21
Systemic manifestations of extraskeletal myxoid chondrosarcoma associated with a novel t(2;22)(q34;q12) EWS translocation in a child and a review of the literature. 61
30776935 2018
22
False-positive findings on 6-[18F]fluor-l-3,4-dihydroxyphenylalanine PET (18F-FDOPA-PET) performed for imaging of neuroendocrine tumors. 61
29875288 2018
23
Molecular and Clinicopathologic Heterogeneity of Intracranial Tumors Mimicking Extraskeletal Myxoid Chondrosarcoma. 61
29924341 2018
24
Benefit of Radiotherapy in Extraskeletal Myxoid Chondrosarcoma: A Propensity Score Weighted Population-based Analysis of the SEER Database. 61
27819877 2018
25
Extra-axial chordoma: a clinicopathologic analysis of six cases. 61
29560513 2018
26
Identification of an Actionable Mutation of KIT in a Case of Extraskeletal Myxoid Chondrosarcoma. 61
29937513 2018
27
[Primary extraskeletal myxoid chondrosarcoma of the corpus callosum: report of a case]. 61
29886600 2018
28
Extraskeletal Chondrosarcoma: Long-term Follow-up of a Patient with Metastatic Disease. 61
30065902 2018
29
INSM1 expression and its diagnostic significance in extraskeletal myxoid chondrosarcoma. 61
29327709 2018
30
Comprehensive high-resolution genomic profiling and cytogenetics of human chondrocyte cultures by GTG-banding, locus-specific FISH, SKY and SNP array. 61
29683471 2018
31
Pre- and postoperative radiotherapy for extremity soft tissue sarcoma: Evaluation of inter-observer target volume contouring variability among French sarcoma group radiation oncologists. 61
29545115 2018
32
Development of a pelvic exenteration service at a tertiary referral centre. 61
29510462 2018
33
Extraskeletal Myxoid Chondrosarcoma of Nasopharynx: An Oncologic Entity Rarely Reported. 61
29657686 2018
34
Myxoid chondrosarcoma extraskeletal in pelvis location : a case report. 61
30325000 2018
35
Extraskeletal Myxoid Chondrosarcoma: A Comparative Study of Imaging and Pathology. 61
29977924 2018
36
Extraskeletal myxoid chondrosarcoma with massive pulmonary metastases. 61
30534357 2018
37
Falcine Myxoid Chondrosarcoma: A Rare Aggressive Case. 61
29492125 2018
38
Anti-Hu-Associated Autoimmune Limbic Encephalitis in a Patient with PD-1 Inhibitor-Responsive Myxoid Chondrosarcoma. 61
29158368 2018
39
Myxoid and reticular angiomatoid fibrous histiocytoma: a case confirmed by fluorescence in situ hybridization analysis for EWSR1 rearrangement. 61
31938448 2018
40
Primary extraskeletal myxoid chondrosarcoma in cerebellum: A case report with literature review: Erratum. 61
29390404 2017
41
Primary pulmonary myxoid sarcoma, a potential mimic of metastatic extraskeletal myxoid chondrosarcoma. 61
29110880 2017
42
Primary extraskeletal myxoid chondrosarcoma in cerebellum: A case report with literature review. 61
29381948 2017
43
Unusual Signal Patterns of Break-apart FISH Probes Used in the Diagnosis of Soft Tissue Sarcomas. 61
28108880 2017
44
Chondroid Lipoma in Left Thigh -A Rare Case Report. 61
28969148 2017
45
Clinical benefit of antiangiogenic therapy in advanced and metastatic chondrosarcoma. 61
28852958 2017
46
HSPA8 as a novel fusion partner of NR4A3 in extraskeletal myxoid chondrosarcoma. 61
28383167 2017
47
Extraskeletal myxoid chondrosarcoma of the masticator space in a pediatric patient. 61
28638563 2017
48
Claudin 6 expression is useful to distinguish myxofibrosarcomas from other myxoid soft tissue tumors. 61
28476380 2017
49
[Histology-Specific Chemotherapy in Soft-Tissue Sarcomas]. 61
28698435 2017
50
Primary extraskeletal myxoid chondrosarcoma of bone: Report of three cases and review of the literature. 61
28249774 2017

Variations for Myxoid Chondrosarcoma

Expression for Myxoid Chondrosarcoma

Search GEO for disease gene expression data for Myxoid Chondrosarcoma.

Pathways for Myxoid Chondrosarcoma

Pathways related to Myxoid Chondrosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 SYP S100B MAPT GFAP
2 10.7 SYP S100B GFAP

GO Terms for Myxoid Chondrosarcoma

Cellular components related to Myxoid Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glial cell projection GO:0097386 8.62 MAPT GFAP

Biological processes related to Myxoid Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cardiac muscle hypertrophy GO:0010613 9.16 PRKCA NR4A3
2 regulation of neuronal synaptic plasticity GO:0048168 8.96 SYP S100B
3 positive regulation of histone H4 acetylation GO:0090240 8.62 SMARCB1 MUC1

Molecular functions related to Myxoid Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.1 TFG SYP S100B MAPT GFAP EWSR1

Sources for Myxoid Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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