MCID: MYX006
MIFTS: 27

Myxoid Leiomyosarcoma

Categories: Cancer diseases, Muscle diseases

Aliases & Classifications for Myxoid Leiomyosarcoma

MalaCards integrated aliases for Myxoid Leiomyosarcoma:

Name: Myxoid Leiomyosarcoma 12 15
Leiomyosarcoma, Myxoid 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5268
MeSH 43 D007890
NCIt 49 C3701
SNOMED-CT 67 16090008
UMLS 71 C0205816

Summaries for Myxoid Leiomyosarcoma

Disease Ontology : 12 A leiomyosarcoma that is characterized by abundant myxoid stroma.

MalaCards based summary : Myxoid Leiomyosarcoma, also known as leiomyosarcoma, myxoid, is related to leiomyosarcoma and vulvar sarcoma. An important gene associated with Myxoid Leiomyosarcoma is ZC3H7B (Zinc Finger CCCH-Type Containing 7B), and among its related pathways/superpathways is Signaling events mediated by HDAC Class II. The drugs Mechlorethamine and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include uterus, ovary and heart.

Related Diseases for Myxoid Leiomyosarcoma

Diseases related to Myxoid Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 leiomyosarcoma 31.2 ZC3H7B PGR ACTC1
2 vulvar sarcoma 30.2 PLAG1 ACTC1
3 heart sarcoma 30.1 ZC3H7B MEAF6
4 smooth muscle tumor 30.0 PGR ACTC1
5 spindle cell carcinoma 29.9 PGR ACTC1
6 carcinosarcoma 29.7 PGR ACTC1
7 endometrial stromal sarcoma 26.6 ZC3H7B YWHAE PGR MEAF6 MBTD1 EZHIP
8 uterine corpus myxoid leiomyosarcoma 12.4
9 conventional leiomyosarcoma 11.8
10 uterine sarcoma 10.5
11 leiomyoma 10.3
12 rare tumor 10.3
13 vulvar leiomyoma 10.2 PLAG1 PGR
14 liver leiomyosarcoma 10.1
15 clear cell sarcoma 10.1 YWHAE BCOR
16 calcifying aponeurotic fibroma 10.1 PGR ACTC1
17 vulvar benign neoplasm 10.1 PLAG1 PGR
18 glycogen-rich clear cell breast carcinoma 10.1 PGR ACTC1
19 myoepithelial carcinoma 10.1 PLAG1 ACTC1
20 benign metastasizing leiomyoma 10.1 PGR ACTC1
21 spindle cell lipoma 10.1 PLAG1 ACTC1
22 bizarre leiomyoma 10.1 PGR ACTC1
23 breast myoepithelial carcinoma 10.1 PGR ACTC1
24 sweat gland disease 10.1 PLAG1 PGR
25 kidney sarcoma 10.1 YWHAE BCOR
26 epithelial-myoepithelial carcinoma 10.1 PLAG1 ACTC1
27 juvenile nasopharyngeal angiofibroma 10.1 PGR ACTC1
28 cystic nephroma 10.1 PGR ACTC1
29 perivascular epithelioid cell tumor 10.0 PGR ACTC1
30 tonsil cancer 10.0 PLAG1 PGR
31 chickenpox 10.0 PGR ACTC1
32 myoepithelioma 10.0 PLAG1 ACTC1
33 oropharynx cancer 10.0 PLAG1 PGR
34 leiomyoma, uterine 10.0
35 ovarian cancer 10.0
36 trichorhinophalangeal syndrome, type i 10.0
37 endometrial cancer 10.0
38 pulmonary hypertension 10.0
39 inflammatory myofibroblastic tumor 10.0
40 myxofibrosarcoma 10.0
41 sarcoma 10.0
42 respiratory failure 10.0
43 uveitis 10.0
44 mitral valve stenosis 10.0
45 benign mesothelioma 10.0
46 transitional cell carcinoma 10.0
47 myoma 10.0
48 mesenchymal cell neoplasm 10.0
49 spindle cell sarcoma 10.0
50 sarcomatoid mesothelioma 10.0

Graphical network of the top 20 diseases related to Myxoid Leiomyosarcoma:



Diseases related to Myxoid Leiomyosarcoma

Symptoms & Phenotypes for Myxoid Leiomyosarcoma

Drugs & Therapeutics for Myxoid Leiomyosarcoma

Drugs for Myxoid Leiomyosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mechlorethamine Approved, Investigational Phase 3 51-75-2 4033
2
Etoposide Approved Phase 3 33419-42-0 36462
3
Epirubicin Approved Phase 3 56420-45-2 41867
4
Ifosfamide Approved Phase 3 3778-73-2 3690
5
Gemcitabine Approved Phase 3 95058-81-4 60750
6
Trabectedin Approved, Investigational Phase 3 114899-77-3 108150
7
Dacarbazine Approved, Investigational Phase 3 4342-03-4 5351166
8
Docetaxel Approved, Investigational Phase 3 114977-28-5 148124
9 Anti-Bacterial Agents Phase 3
10 Alkylating Agents Phase 3
11
Isophosphamide mustard Phase 3 0
12 Antibiotics, Antitubercular Phase 3
13 Immunologic Factors Phase 3
14 Anti-Infective Agents Phase 3
15 Antimitotic Agents Phase 3
16 Antiviral Agents Phase 3
17 Topoisomerase Inhibitors Phase 3
18 Immunosuppressive Agents Phase 3
19 Antimetabolites Phase 3
20 Etoposide phosphate Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Localized High-Risk Soft Tissue Sarcomas Of The Extremities And Trunk Wall In Adults: An Integrating Approach Comprising Standard Vs Histotype-Tailored Neoadjuvant Chemotherapy Recruiting NCT01710176 Phase 3 epirubicin 60 mg/m2/day (days 1, 2) and ifosfamide 3 g/m2/day (days 1, 2, 3);gemcitabine 900 mg/m2 (days 1 and 8) and docetaxel 75 mg/m2 (day 8);trabectedin 1.3 mg/m2;high-dose ifosfamide 14 g/m2, given in in 14 days;etoposide 150 mg/m2/day (days 1, 2, 3) and ifosfamide 3g/m2/day (days 1, 2, 3);gemcitabine 1800 mg/m2 (day 1) and dacarbazine 500 mg/m2 (day 1)

Search NIH Clinical Center for Myxoid Leiomyosarcoma

Genetic Tests for Myxoid Leiomyosarcoma

Anatomical Context for Myxoid Leiomyosarcoma

MalaCards organs/tissues related to Myxoid Leiomyosarcoma:

40
Uterus, Ovary, Heart, Smooth Muscle, Liver, Kidney, Breast

Publications for Myxoid Leiomyosarcoma

Articles related to Myxoid Leiomyosarcoma:

(show top 50) (show all 97)
# Title Authors PMID Year
1
Myxoid smooth muscle neoplasia of the uterus: comprehensive analysis by next-generation sequencing and nucleic acid hybridization. 61
31189997 2019
2
[Clinicopathological study of BCOR rearrangement in high grade endometrial stromal sarcoma]. 61
31422590 2019
3
Novel PLAG1 Gene Rearrangement Distinguishes a Subset of Uterine Myxoid Leiomyosarcoma From Other Uterine Myxoid Mesenchymal Tumors. 61
30489320 2019
4
Inflammatory Myofibroblastic Tumor in Female Genital Tract. 61
29965784 2019
5
Myxoid endometrial stromal sarcoma: report of two cases with emphasis on its diagnostic problems. 61
31933960 2019
6
Malignant transformation of uterine leiomyoma to myxoid leiomyosarcoma after morcellation associated with ALK rearrangement and loss of 14q. 61
29963223 2018
7
ZC3H7B-BCOR high-grade endometrial stromal sarcomas: a report of 17 cases of a newly defined entity. 61
29192652 2018
8
Endometrial stromal sarcomas and related neoplasms: new developments and diagnostic considerations. 61
29275929 2018
9
Uveal myxoid leiomyosarcoma in a horse. 61
29152277 2017
10
Myxoid Mesenchymal Tumors of the Uterus: An Update on Classification, Definitions, and Differential Diagnosis. 61
28787279 2017
11
Abnormal p53 and p16 staining patterns distinguish uterine leiomyosarcoma from inflammatory myofibroblastic tumour. 61
28130839 2017
12
Myxoid leiomyosarcoma of the uterus: a clinicopathological and immunohistochemical study of 10 cases. 61
27717885 2017
13
Novel High-grade Endometrial Stromal Sarcoma: A Morphologic Mimicker of Myxoid Leiomyosarcoma. 61
27631520 2017
14
Myxoid leiomyosarcoma of the cervix: A case report. 61
27937058 2016
15
[Clinicopathologic characteristic of myxoid leiomyosarcoma of the uterus: report of five cases]. 61
27760614 2016
16
Myxoid Leiomyosarcoma of the Uterus: A Clinicopathologic Analysis of 30 Cases and Review of the Literature With Reappraisal of Its Distinction From Other Uterine Myxoid Mesenchymal Neoplasms. 61
26866354 2016
17
Myxoid leiomyosarcoma of the uterus: a case report and review of the literature. 61
29943940 2016
18
Debulking surgery and hyperthermic intraperitoneal chemotherapy in the management of a recurrent aggressive uterine myxoid leiomyosarcoma with peritoneal dissemination. 61
26425725 2015
19
Myxoid leiomyosarcoma of the uterus with mature adipocytes and numerous bizarre multinucleated giant cells. 61
25583277 2015
20
Uterine myxoid leiomyosarcoma with tumor embolism extending into the right atrium. 61
25722901 2015
21
Fibromyxoid variant of endometrial stromal sarcoma with atypical bizarre nuclei. 61
26045860 2015
22
A rare case of uterine myxoid leiomyosarcoma: a case report. 61
25705290 2014
23
Myxoid leiomyosarcoma of the Bartholin gland. 61
25004325 2014
24
Soft-tissue myxomatous lesions: review of salient imaging features with pathologic comparison. 61
25019435 2014
25
Myxoid leiomyosarcoma of ovary-a rare case report. 61
25120990 2014
26
Myxoid leiomyosarcoma of the uterus: a case report. 61
24984552 2014
27
Myxoid leiomyosarcoma of the uterus. 61
22175894 2011
28
Uterine myxoid leiomyosarcoma with an underlying haematological disorder--case report and review of literature. 61
22669996 2011
29
Co-existence of three rare gynecological tumors in a 79-year-old woman. 61
20886347 2011
30
Ocular myxoid leiomyosarcoma in a cat. 61
20149178 2010
31
Myxoid leiomyosarcoma of the uterus: a diagnostic challenge. 61
20882892 2010
32
A rare case of low-grade endometrial stromal sarcoma with myxoid differentiation and atypical bizarre cells. 61
18714579 2008
33
Primary hepatic myxoid leiomyosarcoma: a case report and review of the literature. 61
18300035 2008
34
Primary intravascular myxoid leiomyosarcoma of the femoral vein presenting clinically as deep vein thrombosis: a case report. 61
17109153 2007
35
Inflammatory myofibroblastic tumor of the uterus with prominent myxoid change. 61
16984620 2006
36
Uterine myxoid leiomyosarcoma with widespread metastases in a cat. 61
16846999 2006
37
Myxoid leiomyosarcoma of the uterus in a patient receiving tamoxifen therapy: a case report. 61
16633068 2006
38
Low grade fibromyxoid sarcoma: report of a case with fine needle aspiration cytology and histologic correlation. 61
16610692 2006
39
Myxoid leiomyosarcoma of the liver. 61
16316722 2006
40
Massive myxoid leiomyosarcoma of the uterus. 61
15882188 2005
41
Primary myxoid leiomyosarcoma of the ovary. A case report with review of the literature. 61
16044903 2005
42
Myxoid leiomyosarcoma of the vulva. 61
15661250 2005
43
Disseminating myxoid leiomyosarcoma of the uterus. 61
14749942 2005
44
Recurrent aggressive angiomyxoma of vagina--a case report. 61
16295447 2004
45
Fine-needle aspiration in liposarcoma: cytohistologic correlative study including well-differentiated, myxoid, and pleomorphic variants. 61
15108227 2004
46
Rapid growth of myxoid leiomyosarcoma of the vulva during pregnancy: a case report. 61
14764049 2004
47
Unusual mesenchymal tumour of uterus--a case report with immunohistochemical findings. 61
15025313 2003
48
A case of leiomyosarcoma originating from pulmonary vein, occluding mitral inflow. 61
12827106 2003
49
A case of primary myxoid leiomyosarcoma of the liver. 61
12647647 2002
50
Reassessment and clinicopathological prognostic factors of malignant fibrous histiocytoma of soft parts. 61
12406189 2002

Variations for Myxoid Leiomyosarcoma

Expression for Myxoid Leiomyosarcoma

Search GEO for disease gene expression data for Myxoid Leiomyosarcoma.

Pathways for Myxoid Leiomyosarcoma

Pathways related to Myxoid Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.15 YWHAE BCOR

GO Terms for Myxoid Leiomyosarcoma

Cellular components related to Myxoid Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.23 ZC3H7B YWHAE PLAG1 PGR MEAF6 MBTD1

Biological processes related to Myxoid Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin organization GO:0006325 8.8 MEAF6 MBTD1 BCOR

Sources for Myxoid Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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