MCID: MYX006
MIFTS: 28

Myxoid Leiomyosarcoma

Categories: Cancer diseases, Muscle diseases

Aliases & Classifications for Myxoid Leiomyosarcoma

MalaCards integrated aliases for Myxoid Leiomyosarcoma:

Name: Myxoid Leiomyosarcoma 12 15
Leiomyosarcoma, Myxoid 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5268
MeSH 43 D007890
NCIt 49 C3701
SNOMED-CT 67 16090008
UMLS 71 C0205816

Summaries for Myxoid Leiomyosarcoma

Disease Ontology : 12 A leiomyosarcoma that is characterized by abundant myxoid stroma.

MalaCards based summary : Myxoid Leiomyosarcoma, also known as leiomyosarcoma, myxoid, is related to leiomyosarcoma and vulvar sarcoma. An important gene associated with Myxoid Leiomyosarcoma is ZC3H7B (Zinc Finger CCCH-Type Containing 7B), and among its related pathways/superpathways are Myometrial Relaxation and Contraction Pathways and Signaling events mediated by HDAC Class II. The drugs Gemcitabine and Epirubicin have been mentioned in the context of this disorder. Affiliated tissues include uterus, ovary and heart.

Related Diseases for Myxoid Leiomyosarcoma

Diseases related to Myxoid Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 96, show less)
# Related Disease Score Top Affiliating Genes
1 leiomyosarcoma 31.3 ZC3H7B PGR ACTC1
2 vulvar sarcoma 30.3 PLAG1 ACTC1
3 heart sarcoma 30.1 ZC3H7B MEAF6
4 uterus leiomyosarcoma 30.1 PGR CALD1
5 spindle cell carcinoma 30.0 PGR ACTC1
6 mesenchymal cell neoplasm 29.9 ZC3H7B CALD1 BCOR
7 carcinosarcoma 29.7 PGR ACTC1
8 smooth muscle tumor 29.7 PGR CALD1 ACTC1
9 inflammatory myofibroblastic tumor 29.5 CALD1 ACTC1
10 endometrial stromal sarcoma 26.7 ZC3H7B YWHAE PGR MEAF6 EZHIP CALD1
11 uterine corpus myxoid leiomyosarcoma 12.5
12 conventional leiomyosarcoma 11.8
13 uterine sarcoma 10.5
14 leiomyoma 10.3
15 rare tumor 10.3
16 calcifying aponeurotic fibroma 10.2 PGR ACTC1
17 glycogen-rich clear cell breast carcinoma 10.2 PGR ACTC1
18 myoepithelial carcinoma 10.2 PLAG1 ACTC1
19 benign metastasizing leiomyoma 10.2 PGR ACTC1
20 sweat gland benign neoplasm 10.2 PLAG1 PGR
21 nephroma 10.1 PGR ACTC1
22 liver leiomyosarcoma 10.1
23 adult cystic nephroma 10.1 PGR ACTC1
24 sweat gland disease 10.1 PLAG1 PGR
25 breast myoepithelial carcinoma 10.1 PGR ACTC1
26 pulmonary vein leiomyosarcoma 10.1 PGR CALD1
27 lung leiomyoma 10.1 PGR CALD1
28 diffuse peritoneal leiomyomatosis 10.1 PGR CALD1
29 peritoneal benign neoplasm 10.1 PGR CALD1
30 tonsil cancer 10.1 PLAG1 PGR
31 juvenile nasopharyngeal angiofibroma 10.1 PGR ACTC1
32 chondrosarcoma, extraskeletal myxoid 10.1 PLAG1 BCOR
33 intravenous leiomyomatosis 10.1 PGR CALD1
34 cervical polyp 10.1 PGR CALD1
35 glomangiomyoma 10.1 CALD1 ACTC1
36 myoepithelioma 10.1 PLAG1 ACTC1
37 urethral benign neoplasm 10.1 PGR CALD1
38 chickenpox 10.1 PGR ACTC1
39 cervical adenoma malignum 10.1 PGR CALD1
40 cutaneous leiomyosarcoma 10.1 CALD1 ACTC1
41 adenomyoma 10.1 PGR CALD1
42 vaginal cancer 10.0 PGR CALD1
43 glomangioma 10.0 CALD1 ACTC1
44 angiolipoma 10.0 CALD1 ACTC1
45 spindle cell lipoma 10.0 CALD1 ACTC1
46 oropharynx cancer 10.0 PLAG1 PGR
47 pseudosarcomatous fibromatosis 10.0 CALD1 ACTC1
48 leiomyoma, uterine 10.0
49 ovarian cancer 10.0
50 trichorhinophalangeal syndrome, type i 10.0
51 endometrial cancer 10.0
52 pulmonary hypertension 10.0
53 myxofibrosarcoma 10.0
54 sarcoma 10.0
55 respiratory failure 10.0
56 uveitis 10.0
57 mitral valve stenosis 10.0
58 benign mesothelioma 10.0
59 transitional cell carcinoma 10.0
60 myoma 10.0
61 spindle cell sarcoma 10.0
62 sarcomatoid mesothelioma 10.0
63 ovary leiomyosarcoma 10.0
64 sarcomatosis 10.0
65 47,xyy 10.0
66 infantile myofibromatosis 10.0 CALD1 ACTC1
67 lipomatosis, multiple 10.0 PLAG1 CALD1
68 glomus tumor 10.0 CALD1 ACTC1
69 uterine benign neoplasm 10.0 PGR CALD1
70 well-differentiated liposarcoma 10.0 PLAG1 CALD1
71 reproductive organ benign neoplasm 10.0 PGR CALD1
72 hemangiopericytoma, malignant 10.0 CALD1 ACTC1
73 clear cell sarcoma 9.9 YWHAE BCOR
74 angiomyolipoma 9.9 PGR ACTC1
75 cellular congenital mesoblastic nephroma 9.9 YWHAE BCOR
76 congenital mesoblastic nephroma 9.9 YWHAE BCOR
77 pneumothorax 9.9 PGR ACTC1
78 kidney rhabdoid cancer 9.9 YWHAE BCOR
79 kidney sarcoma 9.9 YWHAE BCOR
80 vulvar benign neoplasm 9.9 PLAG1 PGR CALD1
81 vulvar leiomyoma 9.9 PLAG1 PGR CALD1
82 mixed cell type cancer 9.8 PLAG1 PGR CALD1
83 bizarre leiomyoma 9.8 PGR CALD1 ACTC1
84 dedifferentiated liposarcoma 9.8 CALD1 ACTC1
85 epithelioid leiomyosarcoma 9.8 PGR CALD1 ACTC1
86 perivascular epithelioid cell tumor 9.8 PGR CALD1 ACTC1
87 kidney clear cell sarcoma 9.7 ZC3H7B YWHAE BCOR
88 pleomorphic adenoma 9.6 PLAG1 ACTC1
89 adenoid cystic carcinoma 9.6 PLAG1 PGR BCOR ACTC1
90 adenosarcoma 9.6 YWHAE PGR ACTC1
91 ossifying fibromyxoid tumor 9.5 ZC3H7B MEAF6 BCOR ACTC1
92 ovarian endometrioid stromal sarcoma 9.5 YWHAE PGR CALD1
93 vaginal endometrial stromal sarcoma 9.5 YWHAE PGR CALD1
94 vagina sarcoma 9.5 YWHAE PGR CALD1
95 endometrial stromal nodule 8.7 ZC3H7B YWHAE MEAF6 EZHIP CALD1
96 endometrial stromal tumor 8.2 ZC3H7B YWHAE PGR MEAF6 EZHIP CALD1

Graphical network of the top 20 diseases related to Myxoid Leiomyosarcoma:



Diseases related to Myxoid Leiomyosarcoma

Symptoms & Phenotypes for Myxoid Leiomyosarcoma

Drugs & Therapeutics for Myxoid Leiomyosarcoma

Drugs for Myxoid Leiomyosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 20, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved Phase 3 95058-81-4 60750
2
Epirubicin Approved Phase 3 56420-45-2 41867
3
Dacarbazine Approved, Investigational Phase 3 4342-03-4 5351166
4
Trabectedin Approved, Investigational Phase 3 114899-77-3 108150
5
Ifosfamide Approved Phase 3 3778-73-2 3690
6
Mechlorethamine Approved, Investigational Phase 3 51-75-2 4033
7
Docetaxel Approved, Investigational Phase 3 114977-28-5 148124
8
Etoposide Approved Phase 3 33419-42-0 36462
9 Etoposide phosphate Phase 3
10 Immunologic Factors Phase 3
11 Anti-Infective Agents Phase 3
12 Antiviral Agents Phase 3
13 Alkylating Agents Phase 3
14 Immunosuppressive Agents Phase 3
15 Anti-Bacterial Agents Phase 3
16
Isophosphamide mustard Phase 3 0
17 Tubulin Modulators Phase 3
18 Antibiotics, Antitubercular Phase 3
19 Antimetabolites Phase 3
20 Antimitotic Agents Phase 3

Interventional clinical trials:

(showing 1, show less)
# Name Status NCT ID Phase Drugs
1 Localized High-Risk Soft Tissue Sarcomas Of The Extremities And Trunk Wall In Adults: An Integrating Approach Comprising Standard Vs Histotype-Tailored Neoadjuvant Chemotherapy Recruiting NCT01710176 Phase 3 epirubicin 60 mg/m2/day (days 1, 2) and ifosfamide 3 g/m2/day (days 1, 2, 3);gemcitabine 900 mg/m2 (days 1 and 8) and docetaxel 75 mg/m2 (day 8);trabectedin 1.3 mg/m2;high-dose ifosfamide 14 g/m2, given in in 14 days;etoposide 150 mg/m2/day (days 1, 2, 3) and ifosfamide 3g/m2/day (days 1, 2, 3);gemcitabine 1800 mg/m2 (day 1) and dacarbazine 500 mg/m2 (day 1)

Search NIH Clinical Center for Myxoid Leiomyosarcoma

Genetic Tests for Myxoid Leiomyosarcoma

Anatomical Context for Myxoid Leiomyosarcoma

MalaCards organs/tissues related to Myxoid Leiomyosarcoma:

40
Uterus, Ovary, Heart, Smooth Muscle, Liver, Cervix, Adipocyte

Publications for Myxoid Leiomyosarcoma

Articles related to Myxoid Leiomyosarcoma:

(showing 98, show less)
# Title Authors PMID Year
1
A Rare Case of Primary Pleura Myxoid Leiomyosarcoma: FDG PET/CT Finding. 61
32049732 2020
2
Myxoid smooth muscle neoplasia of the uterus: comprehensive analysis by next-generation sequencing and nucleic acid hybridization. 61
31189997 2019
3
[Clinicopathological study of BCOR rearrangement in high grade endometrial stromal sarcoma]. 61
31422590 2019
4
Novel PLAG1 Gene Rearrangement Distinguishes a Subset of Uterine Myxoid Leiomyosarcoma From Other Uterine Myxoid Mesenchymal Tumors. 61
30489320 2019
5
Inflammatory Myofibroblastic Tumor in Female Genital Tract. 61
29965784 2019
6
Myxoid endometrial stromal sarcoma: report of two cases with emphasis on its diagnostic problems. 61
31933960 2019
7
Malignant transformation of uterine leiomyoma to myxoid leiomyosarcoma after morcellation associated with ALK rearrangement and loss of 14q. 61
29963223 2018
8
ZC3H7B-BCOR high-grade endometrial stromal sarcomas: a report of 17 cases of a newly defined entity. 61
29192652 2018
9
Endometrial stromal sarcomas and related neoplasms: new developments and diagnostic considerations. 61
29275929 2018
10
Uveal myxoid leiomyosarcoma in a horse. 61
29152277 2017
11
Myxoid Mesenchymal Tumors of the Uterus: An Update on Classification, Definitions, and Differential Diagnosis. 61
28787279 2017
12
Abnormal p53 and p16 staining patterns distinguish uterine leiomyosarcoma from inflammatory myofibroblastic tumour. 61
28130839 2017
13
Myxoid leiomyosarcoma of the uterus: a clinicopathological and immunohistochemical study of 10 cases. 61
27717885 2017
14
Novel High-grade Endometrial Stromal Sarcoma: A Morphologic Mimicker of Myxoid Leiomyosarcoma. 61
27631520 2017
15
Myxoid leiomyosarcoma of the cervix: A case report. 61
27937058 2016
16
[Clinicopathologic characteristic of myxoid leiomyosarcoma of the uterus: report of five cases]. 61
27760614 2016
17
Myxoid Leiomyosarcoma of the Uterus: A Clinicopathologic Analysis of 30 Cases and Review of the Literature With Reappraisal of Its Distinction From Other Uterine Myxoid Mesenchymal Neoplasms. 61
26866354 2016
18
Myxoid leiomyosarcoma of the uterus: a case report and review of the literature. 61
29943940 2016
19
Debulking surgery and hyperthermic intraperitoneal chemotherapy in the management of a recurrent aggressive uterine myxoid leiomyosarcoma with peritoneal dissemination. 61
26425725 2015
20
Myxoid leiomyosarcoma of the uterus with mature adipocytes and numerous bizarre multinucleated giant cells. 61
25583277 2015
21
Uterine myxoid leiomyosarcoma with tumor embolism extending into the right atrium. 61
25722901 2015
22
Fibromyxoid variant of endometrial stromal sarcoma with atypical bizarre nuclei. 61
26045860 2015
23
A rare case of uterine myxoid leiomyosarcoma: a case report. 61
25705290 2014
24
Myxoid leiomyosarcoma of the Bartholin gland. 61
25004325 2014
25
Soft-tissue myxomatous lesions: review of salient imaging features with pathologic comparison. 61
25019435 2014
26
Myxoid leiomyosarcoma of ovary-a rare case report. 61
25120990 2014
27
Myxoid leiomyosarcoma of the uterus: a case report. 61
24984552 2014
28
Myxoid leiomyosarcoma of the uterus. 61
22175894 2011
29
Uterine myxoid leiomyosarcoma with an underlying haematological disorder--case report and review of literature. 61
22669996 2011
30
Co-existence of three rare gynecological tumors in a 79-year-old woman. 61
20886347 2011
31
Ocular myxoid leiomyosarcoma in a cat. 61
20149178 2010
32
Myxoid leiomyosarcoma of the uterus: a diagnostic challenge. 61
20882892 2010
33
A rare case of low-grade endometrial stromal sarcoma with myxoid differentiation and atypical bizarre cells. 61
18714579 2008
34
Primary hepatic myxoid leiomyosarcoma: a case report and review of the literature. 61
18300035 2008
35
Primary intravascular myxoid leiomyosarcoma of the femoral vein presenting clinically as deep vein thrombosis: a case report. 61
17109153 2007
36
Inflammatory myofibroblastic tumor of the uterus with prominent myxoid change. 61
16984620 2006
37
Uterine myxoid leiomyosarcoma with widespread metastases in a cat. 61
16846999 2006
38
Myxoid leiomyosarcoma of the uterus in a patient receiving tamoxifen therapy: a case report. 61
16633068 2006
39
Low grade fibromyxoid sarcoma: report of a case with fine needle aspiration cytology and histologic correlation. 61
16610692 2006
40
Myxoid leiomyosarcoma of the liver. 61
16316722 2006
41
Massive myxoid leiomyosarcoma of the uterus. 61
15882188 2005
42
Primary myxoid leiomyosarcoma of the ovary. A case report with review of the literature. 61
16044903 2005
43
Myxoid leiomyosarcoma of the vulva. 61
15661250 2005
44
Disseminating myxoid leiomyosarcoma of the uterus. 61
14749942 2005
45
Recurrent aggressive angiomyxoma of vagina--a case report. 61
16295447 2004
46
Fine-needle aspiration in liposarcoma: cytohistologic correlative study including well-differentiated, myxoid, and pleomorphic variants. 61
15108227 2004
47
Rapid growth of myxoid leiomyosarcoma of the vulva during pregnancy: a case report. 61
14764049 2004
48
Unusual mesenchymal tumour of uterus--a case report with immunohistochemical findings. 61
15025313 2003
49
A case of leiomyosarcoma originating from pulmonary vein, occluding mitral inflow. 61
12827106 2003
50
A case of primary myxoid leiomyosarcoma of the liver. 61
12647647 2002
51
Reassessment and clinicopathological prognostic factors of malignant fibrous histiocytoma of soft parts. 61
12406189 2002
52
Peritoneal washing cytology findings of disseminated myxoid leiomyosarcoma of uterus: report of a case with emphasis on possible differential diagnosis. 61
12112816 2002
53
Myxoid leiomyosarcoma of the uterus with subsequent pregnancy and delivery. 61
12051888 2002
54
Myxoid leiomyosarcoma of the gizzard in a broiler chicken. 61
11922347 2002
55
CD10 is a marker for normal and neoplastic endometrial stromal cells. 61
11781522 2002
56
A huge abdominal mass mimicking ovarian cancer: p53-negative but aneuploid myxoid leiomyosarcoma of the uterus. 61
11728667 2001
57
[Myxoid uterine leiomyoma with focal lymphangioma-like pattern]. 61
11797165 2001
58
Myxoid leiomyosarcoma of the left atrium: a rare malignancy of the heart and its comparison with atrial myxoma. 61
11264566 2001
59
Myxoid leiomyosarcoma of the descending thoracic aorta. 61
11241099 2001
60
Myxoid leiomyosarcoma of the uterus. 61
11446377 2000
61
Endometrial stromal tumors: an update on a group of tumors with a protean phenotype. 61
10976906 2000
62
Myxoid leiomyosarcoma of soft tissue, an underrecognized variant. 61
10895815 2000
63
The value of fine-needle aspiration biopsy in the differential diagnosis of adult myxoid sarcoma. 61
10896330 2000
64
Uterine myxoid leiomyosarcoma. 61
10808004 2000
65
Myxoid leiomyosarcoma of the uterus. Report of a case with cytologic findings. 61
10834002 2000
66
Uterine myxoid leiomyosarcoma within a leiomyoma. 61
10746687 2000
67
[Morphology of the cells in myxoid tumors]. 61
11188853 2000
68
Myxoid leiomyosarcoma of the uterus: a case report. 61
10609511 1999
69
Myxoid leiomyosarcoma of the uterus: a case report and review of the literature. 61
9811191 1998
70
[Myxoid leiomyosarcoma of the esophagus]. 61
9654929 1998
71
Perinodular hydropic degeneration of a uterine leiomyoma: a diagnostic challenge. 61
9023411 1997
72
Genital angiomyofibroblastoma. Comparison with aggressive angiomyxoma and other myxoid neoplasms of skin and soft tissue. 61
8980365 1997
73
Immunohistochemistry (Ki-67 and p53) as a tool in determining malignancy in smooth muscle neoplasms (exemplified by a myxoid leiomyosarcoma of the uterus). 61
8980620 1996
74
An unusual myxoid leiomyosarcoma of the heart. 61
8651863 1996
75
[A case of uterine myxoid leiomyosarcoma with positive cytology in pleural effusion]. 61
8936117 1996
76
Pulmonary myxoid leiomyosarcoma. 61
8581153 1995
77
Myxoid leiomyosarcoma of the uterus with unusual malignant histologic pattern--a case report. 61
7557604 1995
78
Malignant lesions of the female genital tract and peritoneum that may be underdiagnosed. 61
7770671 1995
79
Myxoid leiomyosarcoma of the uterine cervix. 61
7835845 1994
80
Uterine myxoid leiomyosarcoma and CYVADIC-etoposide therapy. 61
7806003 1994
81
Myxoid leiomyosarcoma of the uterus. 61
8428703 1993
82
Metastasis of a myxoid leiomyosarcoma via the renal and hepatic portal circulation in a sarus crane (Grus antigone). 61
8473559 1993
83
Diffuse, perinodular, and other patterns of hydropic degeneration within and adjacent to uterine leiomyomas. Problems in differential diagnosis. 61
1309411 1992
84
Myxoid leiomyosarcoma of the ovary: analysis of three cases. 61
1748433 1991
85
Myxoid leiomyosarcoma of the stomach: a case report. 61
1805049 1991
86
Myxoid leiomyosarcoma of the kidney accompanying ipsilateral ureteral transitional cell carcinoma. A case report with cytological, immunohistochemical and ultrastructural study. 61
1776470 1991
87
Pulmonary vein myxoid leiomyosarcoma. 61
2616373 1989
88
Myxoid leiomyosarcoma of the uterus: case report and review of the literature. 61
2660575 1989
89
[Myxoid leiomyosarcoma: immunohistochemical study of a case]. 61
2712877 1989
90
Myxoid leiomyosarcoma of the urinary bladder. 61
3827542 1987
91
Retrovesical myxoid leiomyosarcoma. 61
3778154 1986
92
Gastric leiomyosarcoma with massive myxoid degeneration. A histochemical and ultrastructural study. 61
3012933 1986
93
Uterine leiomyosarcoma with myxoid stroma. 61
3839378 1985
94
[Myxoid leiomyosarcoma of the uterus]. 61
3832337 1985
95
Myxoid leiomyosarcoma. 61
3988243 1985
96
Myxoid leiomyosarcoma of the uterus--a case report with light microscopic and ultrastructural appraisal. 61
6531799 1984
97
Myxoid leiomyosarcoma of the uterus. 61
6511163 1984
98
Myxoid leiomyosarcoma of the uterus. A report of six cases. 61
7180961 1982

Variations for Myxoid Leiomyosarcoma

Expression for Myxoid Leiomyosarcoma

Search GEO for disease gene expression data for Myxoid Leiomyosarcoma.

Pathways for Myxoid Leiomyosarcoma

Pathways related to Myxoid Leiomyosarcoma according to GeneCards Suite gene sharing:

(showing 2, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.62 YWHAE CALD1 ACTC1
2 10.15 YWHAE BCOR

GO Terms for Myxoid Leiomyosarcoma

Molecular functions related to Myxoid Leiomyosarcoma according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 myosin binding GO:0017022 8.62 CALD1 ACTC1

Sources for Myxoid Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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