MCID: MYX001
MIFTS: 39

Myxopapillary Ependymoma

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Myxopapillary Ependymoma

MalaCards integrated aliases for Myxopapillary Ependymoma:

Name: Myxopapillary Ependymoma 12 20 58 15 71
Ependymoma Myxopapillary 54

Characteristics:

Orphanet epidemiological data:

58
myxopapillary ependymoma
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: Adolescent,All ages,Childhood;

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:5075
MeSH 44 D004806
NCIt 50 C3697
SNOMED-CT 67 1623000
ICD10 via Orphanet 33 D43.2
UMLS via Orphanet 72 C0205769
Orphanet 58 ORPHA251643
UMLS 71 C0205769

Summaries for Myxopapillary Ependymoma

GARD : 20 Myxopapillary ependymoma (MEPN) is a slow-growing ependymoma (a type of glioma, which is a tumor that arises from the supportive tissue of the brain and spinal cord). They tend to occur in the lower part of the spinal column and are usually considered to be benign, low-grade or grade I tumors. The age of diagnosis ranges from 6 to 82 years. Symptoms of an ependymoma are related to the location and size of the tumor and may include nausea, vomiting, headache, pain, numbness, bowel or bladder symptoms, and various other signs and symptoms. The cause of ependymomas is unknown. They are known to recur locally (more commonly in individuals diagnosed in childhood). Treatment may vary depending on the location, grade, and whether the tumor has spread to the spine, but typically includes aggressive surgery. Management may also include chemotherapy and radiation therapy.

MalaCards based summary : Myxopapillary Ependymoma, also known as ependymoma myxopapillary, is related to benign ependymoma and cauda equina syndrome, and has symptoms including back pain An important gene associated with Myxopapillary Ependymoma is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are Neuroscience and Spinal Cord Injury. Affiliated tissues include brain, spinal cord and temporal lobe, and related phenotypes are ependymoma and abnormal conus terminalis morphology

Related Diseases for Myxopapillary Ependymoma

Diseases related to Myxopapillary Ependymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 286)
# Related Disease Score Top Affiliating Genes
1 benign ependymoma 32.2 ZFTA SYP NF2 GFAP
2 cauda equina syndrome 30.9 SYP GFAP
3 secretory meningioma 30.7 VIM NF2 MUC1
4 cellular ependymoma 30.7 ZFTA VIM SYP S100B RELA NF2
5 chordoma 30.5 VIM S100B NCAM1 MUC1 MN1 GFAP
6 adenoid cystic carcinoma 30.5 VIM S100B NCAM1 MUC1
7 chondrosarcoma 30.4 VIM S100B MUC1
8 subependymoma 30.2 SYP NCAM1 GFAP
9 leukoencephalopathy, hereditary diffuse, with spheroids 30.2 SYP S100B GFAP
10 benign teratoma 30.2 SYP NCAM1 MUC1
11 malignant astrocytoma 30.1 VIM S100B RELA GFAP
12 paraganglioma 30.0 SYP S100B NCAM1 GFAP
13 pilocytic astrocytoma 30.0 SYP S100B GFAP
14 neurilemmoma 30.0 VIM S100B NF2 MUC1 GFAP
15 neurofibroma 29.8 VIM SYP S100B NF2 MUC1
16 meningioma, familial 29.4 VIM SYP S100B NF2 NCAM1 MUC1
17 chordoid meningioma 29.4 VIM SYP S100B NF2 NCAM1 MUC1
18 anaplastic ependymoma 29.3 VIM SYP S100B RELA NF2 MUC1
19 spinal cord ependymoma 29.1 ZFTA YAP1 NF2 LUC7L2 HOXB13 CTU1
20 rare tumor 10.5
21 back pain 10.4
22 sclerosing perineurioma 10.4 S100B MUC1
23 localized hypertrophic neuropathy 10.4 S100B MUC1
24 reticular perineurioma 10.4 S100B MUC1
25 aggressive digital papillary adenocarcinoma 10.4 S100B MUC1
26 meningeal melanocytoma 10.4 S100B MUC1
27 cerebral primitive neuroectodermal tumor 10.4 S100B MUC1
28 primitive neuroectodermal tumor of the cervix uteri 10.4 VIM GFAP
29 hydromyelia 10.4 VIM S100B
30 non-functioning pituitary adenoma 10.4 S100B MUC1
31 bednar tumor 10.4 VIM S100B
32 nodular hidradenoma 10.4 VIM MUC1
33 endometrial mucinous adenocarcinoma 10.4 VIM MUC1
34 suprasellar meningioma 10.4 NF2 GFAP
35 malignant peritoneal mesothelioma 10.4 NF2 MUC1
36 chondroid chordoma 10.3 VIM MUC1
37 solid adenocarcinoma with mucin production 10.3 NCAM1 MUC1
38 ovarian serous cystadenofibroma 10.3 NCAM1 MUC1
39 odontogenic myxoma 10.3 VIM S100B
40 gemistocytic astrocytoma 10.3 S100B GFAP
41 pericardial mesothelioma 10.3 VIM MUC1
42 epithelioid malignant peripheral nerve sheath tumor 10.3 S100B MUC1
43 reticulum cell sarcoma 10.3 VIM MUC1
44 myopericytoma 10.3 S100B RELA
45 adenofibroma 10.3 VIM MUC1
46 frontal convexity meningioma 10.3 NF2 GFAP
47 intracranial cysts 10.3 S100B MUC1 GFAP
48 siderosis 10.3
49 pediatric meningioma 10.3 NF2 LUC7L2
50 traumatic brain injury 10.3 S100B GFAP

Graphical network of the top 20 diseases related to Myxopapillary Ependymoma:



Diseases related to Myxopapillary Ependymoma

Symptoms & Phenotypes for Myxopapillary Ependymoma

Human phenotypes related to Myxopapillary Ependymoma:

58 31 (show all 12)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ependymoma 58 31 obligate (100%) Obligate (100%) HP:0002888
2 abnormal conus terminalis morphology 58 31 hallmark (90%) Very frequent (99-80%) HP:0031938
3 vomiting 58 31 frequent (33%) Frequent (79-30%) HP:0002013
4 headache 58 31 frequent (33%) Frequent (79-30%) HP:0002315
5 unsteady gait 58 31 frequent (33%) Frequent (79-30%) HP:0002317
6 neck pain 58 31 frequent (33%) Frequent (79-30%) HP:0030833
7 autonomic bladder dysfunction 58 31 frequent (33%) Frequent (79-30%) HP:0005341
8 abnormal large intestine physiology 58 31 frequent (33%) Frequent (79-30%) HP:0012700
9 neoplasm of the skin 58 31 occasional (7.5%) Occasional (29-5%) HP:0008069
10 abnormal sacrum morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0005107
11 abnormality of the auditory canal 58 31 very rare (1%) Very rare (<4-1%) HP:0000372
12 neoplasm of the central nervous system 58 Frequent (79-30%)

UMLS symptoms related to Myxopapillary Ependymoma:


back pain

MGI Mouse Phenotypes related to Myxopapillary Ependymoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.32 CA2 GFAP HOXB13 HOXB5 NCAM1 NF2

Drugs & Therapeutics for Myxopapillary Ependymoma

Search Clinical Trials , NIH Clinical Center for Myxopapillary Ependymoma

Genetic Tests for Myxopapillary Ependymoma

Anatomical Context for Myxopapillary Ependymoma

MalaCards organs/tissues related to Myxopapillary Ependymoma:

40
Brain, Spinal Cord, Temporal Lobe, Lymph Node, Retina, Skin, Cervix

Publications for Myxopapillary Ependymoma

Articles related to Myxopapillary Ependymoma:

(show top 50) (show all 357)
# Title Authors PMID Year
1
Immunohistochemical comparison of chordoma with chondrosarcoma, myxopapillary ependymoma, and chordoid meningioma. 54 61
19521276 2009
2
An immunohistochemical comparison of chordoma with renal cell carcinoma, colorectal adenocarcinoma, and myxopapillary ependymoma: a potential diagnostic dilemma in the diminutive biopsy. 61 54
7504258 1993
3
Outcomes following limited-volume proton therapy for multifocal spinal myxopapillary ependymoma. 61
33226179 2021
4
CSF Otorrhea: A Rare Presentation of Spinal Myxopapillary Ependymoma. 61
33485885 2021
5
Giant intradural myxopapillary ependymoma: review of literature. 61
33509888 2021
6
Clinical features, treatments, and prognostic factors of spinal myxopapillary ependymoma. 61
33412325 2021
7
Preoperative Intracranial Dissemination of Spinal Myxopapillary Ependymoma Attributed to Tumor Hemorrhage. 61
32889190 2021
8
Two cases of normal pressure hydrocephalus caused by ependymoma of the cauda equina. 61
33500823 2021
9
Long-term outcomes of spinal ependymomas: an institutional experience of more than 60 cases. 61
33179213 2021
10
Metastatic myxopapillary ependymoma treated with immunotherapy achieving durable response. 61
33334744 2020
11
Overexpression of Long Noncoding RNA HOTAIR Is a Unique Epigenetic Characteristic of Myxopapillary Ependymoma. 61
32940681 2020
12
Tumors in the cauda equina: A SEER analysis of tumor types and predictors of outcome. 61
33222921 2020
13
Anaplastic Transformation in Myxopapillary Ependymoma: A Report of 2 Cases and Review of the Literature. 61
32743660 2020
14
Atypical Imaging of Hemorrhagic Lumbosacral Myxopapillary Ependymoma with Histopathological Correlation: A Case Report. 61
33082304 2020
15
Clinical characteristics and surgical outcomes of spinal myxopapillary ependymomas. 61
31473875 2020
16
First-Onset Hypokalemic Periodic Paralysis Following Surgery for Myxopapillary Ependymoma. 61
32585385 2020
17
cIMPACT-NOW update 7: advancing the molecular classification of ependymal tumors. 61
32502305 2020
18
Intramedullary Masses of the Spinal Cord: Radiologic-Pathologic Correlation. 61
32530746 2020
19
An unexpected diagnosis of paediatric subcutaneous sacrococcygeal extraspinal ependymoma: lessons learnt and review of the literature. 61
32665839 2020
20
Diagnosis: subcutaneous myxopapillary ependymoma. 61
32172345 2020
21
Long-term survival of a sacro-coccygeal myxopapillary ependymoma with extra-neural metastases: case report and review of the literature. 61
31989347 2020
22
Diagnosis: Subcutaneous myxopapillary ependymoma. 61
32147755 2020
23
Mobile Myxopapillary Ependymoma with Associated Filum Terminale Cyst. 61
32339736 2020
24
MYXOPAPILLARY EPENDYMOMA OF THE SPINAL CORD IN ADULTS: A REPORT OF PERSONAL SERIES AND REVIEW OF LITERATURE. 61
33456121 2020
25
Analyzing the role of adjuvant or salvage radiotherapy for spinal myxopapillary ependymomas. 61
32357340 2020
26
Long-Term Surgical Resection Outcomes of Pediatric Myxopapillary Ependymoma: Experience of Two Centers and Brief Literature Review. 61
31899399 2020
27
Resection of Myxopapillary Ependymoma of the Filum Terminale: 2-Dimensional Operative Video. 61
31073602 2020
28
Myxopapillary ependymoma of the sacrum. 61
31555979 2020
29
Molecular characterization of histopathological ependymoma variants. 61
31679042 2020
30
Filum Terminale Ependymoma in an Infant with Meningocele. 61
31962322 2020
31
Reports of a Conus Cauda Tumor with Holocord Syrinx in an Adolescent Girl. 61
32435308 2020
32
Spinal Seeding Metastasis of Myxopapillary Ependymoma: Report of Three Pediatric Patients and a Brief Literature Review. 61
32777780 2020
33
Image report: Extensive disseminated thoracolumbosacral myxopapillary ependymoma. 61
33093974 2020
34
Subcutaneous sacrococcygeal myxopapillary ependymoma misdiagnosed as pilonidal disease. 61
31900294 2020
35
TERTp Mutation Detection in Plasma by Droplet-Digital Polymerase Chain Reaction in Spinal Myxopapillary Ependymoma with Lung Metastases. 61
31330336 2019
36
Spinal Myxopapillary Ependymoma: The Sapienza University Experience and Comprehensive Literature Review Concerning the Clinical Course of 1602 Patients. 61
31152881 2019
37
Myxopapillary ependymoma of cauda equina presented with communicating hydrocephalus and papilloedema: A case report. 61
31424046 2019
38
[Superficial siderosis of the central nervous system caused by myxopapillary ependymoma of conus medullaris and cauda equine: a case report and literature review]. 61
31420638 2019
39
Management and Outcome Analysis of Conus and Filum ependymoma: A Tertiary Center Study. 61
31497108 2019
40
Benign ependymoma with extensive intracranial and spinal cerebrospinal fluid dissemination: case report and literature review. 61
28633540 2019
41
Invasive myxopapillary ependymoma of the lumbar spine: A case report. 61
31183345 2019
42
Myxopapillary Ependymoma. 61
30844350 2019
43
Intradural Extramedullary Spinal Neoplasms: Radiologic-Pathologic Correlation. 61
30844353 2019
44
Recurrent Extradural Myxopapillary Ependymoma With Oligometastatic Spread. 61
31850213 2019
45
A rare case of an intramedullary metastasis of a myxopapillary ependymoma. 61
31528421 2019
46
Natural Course of Myxopapillary Ependymoma: Unusual Case Report and Review of Literature. 61
30321682 2019
47
DNA methylation-based classification of ependymomas in adulthood: implications for diagnosis and treatment. 61
30053291 2018
48
Isolated myxopapillary ependymoma of the fourth ventricle: case report and review of literature. 61
30317890 2018
49
Pediatric extraspinal sacrococcygeal ependymoma (ESE): an Italian AIEOP experience of six cases and literature review. 61
29725826 2018
50
Remarkable efficacy of temozolomide for relapsed spinal myxopapillary ependymoma with multiple recurrence and cerebrospinal dissemination: a case report and literature review. 61
29270703 2018

Variations for Myxopapillary Ependymoma

Expression for Myxopapillary Ependymoma

Search GEO for disease gene expression data for Myxopapillary Ependymoma.

Pathways for Myxopapillary Ependymoma

Pathways related to Myxopapillary Ependymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.97 SYP S100B NF2 NCAM1 GFAP CA2
2 11.51 VIM PLA2G5 GFAP
3
Show member pathways
11.37 YAP1 S100B GFAP
4 10.92 VIM SYP S100B NCAM1 GFAP

GO Terms for Myxopapillary Ependymoma

Biological processes related to Myxopapillary Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament organization GO:0045109 9.32 VIM GFAP
2 astrocyte development GO:0014002 9.26 VIM GFAP
3 Bergmann glial cell differentiation GO:0060020 9.16 VIM GFAP
4 regulation of stem cell proliferation GO:0072091 8.96 YAP1 NF2
5 intermediate filament-based process GO:0045103 8.62 VIM GFAP

Sources for Myxopapillary Ependymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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