Aliases & Classifications for Myxosarcoma

MalaCards integrated aliases for Myxosarcoma:

Name: Myxosarcoma 12 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4136
MeSH 45 D009236
NCIt 51 C3255
SNOMED-CT 69 28351005
UMLS 74 C0027155

Summaries for Myxosarcoma

MalaCards based summary : Myxosarcoma is related to mesenchymoma and meninges sarcoma. An important gene associated with Myxosarcoma is MB (Myoglobin), and among its related pathways/superpathways are MicroRNAs in cancer and Cellular senescence (KEGG). The drugs Fluorouracil and Belinostat have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and bone, and related phenotypes are Decreased TP53 mRNA expression and cardiovascular system

Wikipedia : 77 Myxosarcoma is a rare malignant tumor of the... more...

Related Diseases for Myxosarcoma

Diseases related to Myxosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 mesenchymoma 10.4 MB MDM2
2 meninges sarcoma 10.4 MB TP53
3 orbital cancer 10.4 MB SYP
4 papillary tumor of the pineal region 10.4 S100A1 SYP
5 ring chromosome 7 10.3 MDM2 TP53
6 zika virus infection 10.3 MDM2 TP53
7 actinic cheilitis 10.3 MDM2 TP53
8 cellular ependymoma 10.3 SYP TP53
9 lip cancer 10.3 MDM2 TP53
10 atypical follicular adenoma 10.3 SYP TP53
11 central nervous system primitive neuroectodermal neoplasm 10.3 SYP TP53
12 cerebellum cancer 10.3 SYP TP53
13 olfactory groove meningioma 10.3 SYP TP53
14 giant cell myocarditis 10.3 CD68 MB
15 cerebral neuroblastoma 10.3 SYP TP53
16 male reproductive organ benign neoplasm 10.3 PRKAR1A SYP
17 virus associated hemophagocytic syndrome 10.3 CD68 MB
18 angiomyoma 10.3 MB SYP
19 sapho syndrome 10.3 MDM2 TP53
20 malignant teratoma 10.3 SYP TP53
21 cerebral ventricle cancer 10.3 SYP TP53
22 cavernous hemangioma 10.2 MB S100A1 SYP
23 synchronous bilateral breast carcinoma 10.2 ATM TP53
24 glycogen-rich clear cell breast carcinoma 10.2 SYP TP53
25 nodular ganglioneuroblastoma 10.2 MDM2 SYP
26 uterine sarcoma 10.2 ABCB1 MB MDM2
27 sclerosing liposarcoma 10.2 MB MDM2 TP53
28 liposarcoma 10.2 MB MDM2 TP53
29 malignant mesenchymoma 10.2 MB MDM2 TP53
30 periosteal osteogenic sarcoma 10.2 MDM2 TP53
31 muscle cancer 10.2 MB MDM2 TP53
32 visual agnosia 10.2 MB SYP
33 adenosarcoma 10.2 MB TP53
34 cellular schwannoma 10.2 MDM2 S100A1 TP53
35 histiocytoma 10.2 MB MDM2 TP53
36 rhabdoid cancer 10.2 MB SYP TP53
37 mixed cell type cancer 10.2 MB SYP TP53
38 medullomyoblastoma 10.2 MB SYP TP53
39 inflammatory mfh 10.2 CD68 MDM2
40 malignant peripheral nerve sheath tumor 10.2 MDM2 S100A1 TP53
41 bladder carcinoma in situ 10.2 CD68 TP53
42 cll/sll 10.2 ATM TP53
43 scrotal carcinoma 10.2 CD68 TP53
44 conventional fibrosarcoma 10.2 CD68 MDM2
45 soft tissue sarcoma 10.2 ABCB1 MDM2 TP53
46 skin melanoma 10.2 MDM2 NME1 TP53
47 trigeminal nerve neoplasm 10.2 CD68 PRKAR1A
48 neurilemmoma of the fifth cranial nerve 10.2 CD68 PRKAR1A
49 anaplastic ependymoma 10.2 MDM2 SYP
50 plica syndrome 10.2 CD68 VWF

Graphical network of the top 20 diseases related to Myxosarcoma:



Diseases related to Myxosarcoma

Symptoms & Phenotypes for Myxosarcoma

GenomeRNAi Phenotypes related to Myxosarcoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased TP53 mRNA expression GR00389-S-5 8.62 ATM TP53

MGI Mouse Phenotypes related to Myxosarcoma:

47 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.19 ABCB1 ANO1 ATM MB MDM2 PLG
2 homeostasis/metabolism MP:0005376 10.13 ABCB1 ANO1 ATM MB MDM2 PLG
3 hematopoietic system MP:0005397 10.11 ABCB1 ATM CD68 MB MDM2 PLG
4 digestive/alimentary MP:0005381 10.02 ABCB1 ANO1 MDM2 PLG PRKAR1A TP53
5 mortality/aging MP:0010768 10.02 ABCB1 ANO1 ATM MB MDM2 NME1
6 integument MP:0010771 10.01 ANO1 ATM MDM2 MLANA NME1 PLG
7 liver/biliary system MP:0005370 9.85 ABCB1 MDM2 NME1 PLG PRKAR1A TP53
8 nervous system MP:0003631 9.81 ABCB1 ANO1 ATM MDM2 NME1 PLG
9 neoplasm MP:0002006 9.73 ATM MDM2 NME1 PLG PRKAR1A TP53
10 no phenotypic analysis MP:0003012 9.43 ABCB1 CD68 MDM2 MLANA TP53 VWF
11 respiratory system MP:0005388 9.1 ANO1 MB PLG PRKAR1A S100A1 TP53

Drugs & Therapeutics for Myxosarcoma

Drugs for Myxosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 1 51-21-8 3385
2
Belinostat Approved, Investigational Phase 1 866323-14-0
3
Parathyroid hormone Approved, Investigational Phase 1 9002-64-6
4 Immunologic Factors Phase 1
5 Androgens Phase 1
6 Histone Deacetylase Inhibitors Phase 1
7 Antimetabolites Phase 1
8 Immunosuppressive Agents Phase 1
9 Antimetabolites, Antineoplastic Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1 belinostat;5-Fluorouracil (5-FU)

Search NIH Clinical Center for Myxosarcoma

Cochrane evidence based reviews: myxosarcoma

Genetic Tests for Myxosarcoma

Anatomical Context for Myxosarcoma

MalaCards organs/tissues related to Myxosarcoma:

42
Brain, Skin, Bone, Eye, Pituitary, Pineal, Cerebellum

Publications for Myxosarcoma

Articles related to Myxosarcoma:

(show top 50) (show all 62)
# Title Authors Year
1
Metastatic myxosarcoma in a Quarter Horse gelding. ( 28677418 )
2018
2
Extracardiac intrapericardial myxosarcoma causing right ventricular outflow tract obstruction in a dog. ( 29500126 )
2018
3
Canine low-grade intra-orbital myxosarcoma: case report. ( 24837165 )
2015
4
Long-term survival after extended resection of primary atrial myxosarcoma. ( 25583907 )
2015
5
Myxosarcoma of the maxilla - a case report. ( 25954712 )
2015
6
What Is Your Diagnosis? Myxosarcoma in a cat. ( 26331415 )
2015
7
Metronomic Chemotherapy for Myxosarcoma Treatment in a Kori Bustard (Ardeotis kori). ( 26378667 )
2015
8
Cardiac myxosarcoma with thoracic spinal metastasis. ( 23677508 )
2014
9
Diagnosis and treatment of a periocular myxosarcoma in a bearded dragon (Pogona vitticeps). ( 24982518 )
2014
10
What is your diagnosis? Grade 2 myxosarcoma of the subcutis and bone. ( 25406700 )
2014
11
Axillary artery tumor embolism secondary to mitral valve myxosarcoma in a dog. ( 25471647 )
2014
12
What is your diagnosis? Low-grade myxosarcoma arising from the heart valve. ( 23547667 )
2013
13
Intrathoracic myxosarcoma in a dog. ( 22520813 )
2012
14
Multiple cerebral aneurysms and brain metastasis from primary cardiac myxosarcoma: a case report and literature review. ( 21733362 )
2011
15
Cutaneous myxosarcoma with pulmonary metastases in a dog. ( 21310431 )
2011
16
Surgical treatment of cardiac myxosarcoma. ( 21484557 )
2011
17
Cardiac myxosarcoma with adrenal adenoma and pituitary hyperplasia resembling Carney complex in a dog. ( 20110224 )
2010
18
Primary myxosarcoma of the right inferior pulmonary vein presenting clinically as benign left atrial myxoma with a concurrent right lower lung tumor. ( 19139592 )
2009
19
Imaging features of orbital myxosarcoma in dogs. ( 18546781 )
2008
20
Endobronchial polyp derived from a myxosarcoma in the lung of a dog. ( 18981198 )
2008
21
Left atrial myxosarcoma with previously detected intestinal metastasis. ( 17420810 )
2007
22
Left atrium myxosarcoma: an exceptional cardiac malignant primary tumor. ( 17551954 )
2007
23
Odontogenic myxosarcoma of the jaw in a dog. ( 17993660 )
2007
24
Imaging diagnosis--spinal myxosarcoma in a dog. ( 18018729 )
2007
25
Spontaneous subcutaneous myxosarcoma in a captive European hedgehog (Erinsceus europaeus). ( 17121099 )
2006
26
Carpal myxosarcoma and forelimb amputation in a ferret (Mustela putorius furo). ( 17142629 )
2006
27
Myxosarcoma of the right ventricle: an immunohistochemical and ultrastructural study. ( 12926105 )
2003
28
Myxosarcoma in the eye and brain in a dog. ( 12950648 )
2003
29
Left ventricular myxosarcoma in a dog. ( 14635963 )
2003
30
Cardiac myxoma and myxosarcoma: clinical experience and immunohistochemistry. ( 12079962 )
2002
31
Myxosarcoma: a rare primary cardiac tumor. ( 12517027 )
2002
32
Nasopharyngeal myxosarcoma in a Bengal tiger (Panthera tigris). ( 12564536 )
2002
33
Left atrial myxosarcoma with systemic metastasis: a case report. ( 11289388 )
2001
34
Right atrial myxosarcoma in a dog. ( 9561500 )
1997
35
Primary left atrial myxosarcoma. ( 7691044 )
1993
36
Surgical treatment of pulmonary artery primary myxosarcoma. ( 8599076 )
1993
37
Intestinal myxosarcoma in a thoroughbred mare. ( 1623729 )
1992
38
Myxosarcoma in a Sinaloan milksnake. ( 1813474 )
1991
39
Myxosarcoma in a dog. ( 12684949 )
1990
40
Cytogenetic analysis of a gossypol-induced murine myxosarcoma. ( 3473256 )
1987
41
A case of malignant myxoma (myxosarcoma) of the maxilla. ( 6591371 )
1984
42
Primary cardiac myxosarcoma in a child. ( 423607 )
1979
43
Myxosarcoma in a wapiti. ( 480522 )
1979
44
Myxosarcoma in a young rhesus monkey. ( 809897 )
1975
45
Recurrent myxosarcoma of left atrium. ( 1126234 )
1975
46
Spontaneous myxosarcoma in a cottontail rabbit (Sylvilagus floridanus): observation of tubular structures in the endoplasmic reticulum of tumor cells. ( 4737213 )
1973
47
Myxosarcoma of the pulmonary valve. ( 5082046 )
1972
48
Myxosarcoma of the orbit (a case report). ( 15744961 )
1971
49
Primary myxosarcoma of leg. ( 4905664 )
1970
50
Properties of hyaluronic acid from a human myxosarcoma. ( 5870108 )
1965

Variations for Myxosarcoma

Expression for Myxosarcoma

Search GEO for disease gene expression data for Myxosarcoma.

Pathways for Myxosarcoma

GO Terms for Myxosarcoma

Biological processes related to Myxosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signal transduction by p53 class mediator GO:1901796 9.43 ATM MDM2 TP53
2 positive regulation of protein export from nucleus GO:0046827 9.37 MDM2 TP53
3 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.33 ATM MDM2 TP53
4 replicative senescence GO:0090399 9.32 ATM TP53
5 cellular response to actinomycin D GO:0072717 8.96 MDM2 TP53
6 cellular response to gamma radiation GO:0071480 8.8 ATM MDM2 TP53

Molecular functions related to Myxosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.56 MDM2 NME1 PLG TP53
2 identical protein binding GO:0042802 9.43 MDM2 NME1 S100A1 SYP TP53 VWF
3 chaperone binding GO:0051087 9.33 PLG TP53 VWF
4 protein N-terminus binding GO:0047485 8.92 ATM MDM2 TP53 VWF

Sources for Myxosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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