Aliases & Classifications for Myxosarcoma

MalaCards integrated aliases for Myxosarcoma:

Name: Myxosarcoma 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4136
MeSH 44 D009236
NCIt 50 C3255
SNOMED-CT 68 28351005
UMLS 73 C0027155

Summaries for Myxosarcoma

MalaCards based summary : Myxosarcoma is related to meninges sarcoma and mesenchymoma. An important gene associated with Myxosarcoma is MB (Myoglobin), and among its related pathways/superpathways are PI3K-Akt signaling pathway and MicroRNAs in cancer. The drugs Belinostat and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and behavior/neurological

Wikipedia : 76 Myxosarcoma is a rare malignant tumor of the... more...

Related Diseases for Myxosarcoma

Diseases related to Myxosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 meninges sarcoma 10.8 MB TP53
2 mesenchymoma 10.7 MB MDM2
3 ring chromosome 7 10.7 MDM2 TP53
4 zika virus infection 10.7 MDM2 TP53
5 papillary tumor of the pineal region 10.7 S100A1 SYP
6 actinic cheilitis 10.6 MDM2 TP53
7 cellular ependymoma 10.6 SYP TP53
8 giant cell myocarditis 10.6 CD68 MB
9 virus associated hemophagocytic syndrome 10.6 CD68 MB
10 atypical follicular adenoma 10.5 SYP TP53
11 sclerosing liposarcoma 10.5 MB MDM2 TP53
12 lip cancer 10.5 MDM2 TP53
13 central nervous system primitive neuroectodermal neoplasm 10.5 SYP TP53
14 uterine sarcoma 10.5 ABCB1 MB MDM2
15 cerebellum cancer 10.5 SYP TP53
16 malignant mesenchymoma 10.5 MB MDM2 TP53
17 muscle cancer 10.5 MB MDM2 TP53
18 cellular schwannoma 10.5 MDM2 S100A1 TP53
19 uterine corpus serous adenocarcinoma 10.5 BRCA1 TP53
20 mixed cell type cancer 10.5 MB SYP TP53
21 cerebral neuroblastoma 10.5 SYP TP53
22 medullomyoblastoma 10.5 MB SYP TP53
23 histiocytoma 10.5 MB MDM2 TP53
24 liposarcoma 10.4 MB MDM2 TP53
25 soft tissue sarcoma 10.4 ABCB1 MDM2 TP53
26 malignant peripheral nerve sheath tumor 10.4 MDM2 S100A1 TP53
27 adult medulloblastoma 10.4 MDM2 SYP TP53
28 cerebral ventricle cancer 10.3 SYP TP53
29 plica syndrome 10.3 CD68 VWF
30 giant cell glioblastoma 10.3 MDM2 SYP TP53
31 adrenocortical carcinoma, hereditary 10.3 PRKAR1A SYP TP53
32 inflammatory mfh 10.3 CD68 MDM2
33 cerebrum cancer 10.3 SYP TP53
34 sarcomatoid squamous cell skin carcinoma 10.3 CD68 MB TP53
35 nervous system cancer 10.3 MDM2 SYP TP53
36 papillary serous adenocarcinoma 10.3 BRCA1 TP53
37 leiomyosarcoma 10.3 MB MDM2 S100A1 TP53
38 ovarian cancer 1 10.3 BRCA1 NME1 TP53
39 malignant ovarian surface epithelial-stromal neoplasm 10.3 BRCA1 NME1 TP53
40 mixed liposarcoma 10.3 CD68 MB MDM2
41 ovary epithelial cancer 10.3 BRCA1 NME1 TP53
42 bladder carcinoma in situ 10.3 CD68 TP53
43 ischemic fasciitis 10.3 CD68 MDM2 S100A1
44 glycogen-rich clear cell breast carcinoma 10.2 BRCA1 SYP TP53
45 breast ductal carcinoma 10.2 BRCA1 NME1 TP53
46 synchronous bilateral breast carcinoma 10.2 ATM BRCA1 TP53
47 conventional fibrosarcoma 10.1 CD68 MDM2
48 female breast cancer 10.1 ATM BRCA1 TP53
49 nijmegen breakage syndrome 10.1 ATM BRCA1 TP53
50 sporadic breast cancer 10.1 ATM BRCA1 TP53

Graphical network of the top 20 diseases related to Myxosarcoma:



Diseases related to Myxosarcoma

Symptoms & Phenotypes for Myxosarcoma

GenomeRNAi Phenotypes related to Myxosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.1 ANO1 ATM BRCA1 MDM2 NUDT1 TP53

MGI Mouse Phenotypes related to Myxosarcoma:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.19 ABCB1 ANO1 ATM BRCA1 MDM2 NUDT1
2 cardiovascular system MP:0005385 10.18 ABCB1 ANO1 ATM BRCA1 MB MDM2
3 hematopoietic system MP:0005397 10.17 ABCB1 ATM BRCA1 CD68 MB MDM2
4 homeostasis/metabolism MP:0005376 10.14 ABCB1 ANO1 ATM BRCA1 MB MDM2
5 immune system MP:0005387 10.07 ABCB1 ATM BRCA1 CD68 MDM2 NME2
6 digestive/alimentary MP:0005381 10 ABCB1 ANO1 BRCA1 MDM2 PRKAR1A TP53
7 integument MP:0010771 9.92 ANO1 ATM BRCA1 MDM2 MLANA NME1
8 muscle MP:0005369 9.8 TP53 ANO1 BRCA1 MB MDM2 PRKAR1A
9 neoplasm MP:0002006 9.7 TP53 ATM BRCA1 MDM2 NME1 NUDT1
10 nervous system MP:0003631 9.65 ABCB1 ANO1 ATM BRCA1 MDM2 NME1
11 pigmentation MP:0001186 9.02 BRCA1 MDM2 MLANA PRKAR1A TP53

Drugs & Therapeutics for Myxosarcoma

Drugs for Myxosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Belinostat Approved, Investigational Phase 1 866323-14-0
2
Fluorouracil Approved Phase 1 51-21-8 3385
3 Androgens Phase 1
4 Antimetabolites Phase 1
5 Antimetabolites, Antineoplastic Phase 1
6 Histone Deacetylase Inhibitors Phase 1
7 Immunosuppressive Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1 belinostat;5-Fluorouracil (5-FU)

Search NIH Clinical Center for Myxosarcoma

Cochrane evidence based reviews: myxosarcoma

Genetic Tests for Myxosarcoma

Anatomical Context for Myxosarcoma

MalaCards organs/tissues related to Myxosarcoma:

41
Heart, Lung, Brain, Skin, Pituitary, Eye, Bone

Publications for Myxosarcoma

Articles related to Myxosarcoma:

(show top 50) (show all 61)
# Title Authors Year
1
Extracardiac intrapericardial myxosarcoma causing right ventricular outflow tract obstruction in a dog. ( 29500126 )
2018
2
Metastatic myxosarcoma in a Quarter Horse gelding. ( 28677418 )
2017
3
Myxosarcoma of the maxilla - a case report. ( 25954712 )
2015
4
Long-term survival after extended resection of primary atrial myxosarcoma. ( 25583907 )
2015
5
What Is Your Diagnosis? Myxosarcoma in a cat. ( 26331415 )
2015
6
Metronomic Chemotherapy for Myxosarcoma Treatment in a Kori Bustard (Ardeotis kori). ( 26378667 )
2015
7
Axillary artery tumor embolism secondary to mitral valve myxosarcoma in a dog. ( 25471647 )
2014
8
What is your diagnosis? Grade 2 myxosarcoma of the subcutis and bone. ( 25406700 )
2014
9
Diagnosis and treatment of a periocular myxosarcoma in a bearded dragon (Pogona vitticeps). ( 24982518 )
2014
10
Canine low-grade intra-orbital myxosarcoma: case report. ( 24837165 )
2014
11
What is your diagnosis? Low-grade myxosarcoma arising from the heart valve. ( 23547667 )
2013
12
Cardiac myxosarcoma with thoracic spinal metastasis. ( 23677508 )
2013
13
Intrathoracic myxosarcoma in a dog. ( 22520813 )
2012
14
Surgical treatment of cardiac myxosarcoma. ( 21484557 )
2011
15
Multiple cerebral aneurysms and brain metastasis from primary cardiac myxosarcoma: a case report and literature review. ( 21733362 )
2011
16
Cutaneous myxosarcoma with pulmonary metastases in a dog. ( 21310431 )
2011
17
Cardiac myxosarcoma with adrenal adenoma and pituitary hyperplasia resembling Carney complex in a dog. ( 20110224 )
2010
18
Primary myxosarcoma of the right inferior pulmonary vein presenting clinically as benign left atrial myxoma with a concurrent right lower lung tumor. ( 19139592 )
2009
19
Imaging features of orbital myxosarcoma in dogs. ( 18546781 )
2008
20
Endobronchial polyp derived from a myxosarcoma in the lung of a dog. ( 18981198 )
2008
21
Left atrial myxosarcoma with previously detected intestinal metastasis. ( 17420810 )
2007
22
Left atrium myxosarcoma: an exceptional cardiac malignant primary tumor. ( 17551954 )
2007
23
Odontogenic myxosarcoma of the jaw in a dog. ( 17993660 )
2007
24
Imaging diagnosis--spinal myxosarcoma in a dog. ( 18018729 )
2007
25
Carpal myxosarcoma and forelimb amputation in a ferret (Mustela putorius furo). ( 17142629 )
2006
26
Spontaneous subcutaneous myxosarcoma in a captive European hedgehog (Erinsceus europaeus). ( 17121099 )
2006
27
Myxosarcoma of the right ventricle: an immunohistochemical and ultrastructural study. ( 12926105 )
2003
28
Myxosarcoma in the eye and brain in a dog. ( 12950648 )
2003
29
Left ventricular myxosarcoma in a dog. ( 14635963 )
2003
30
Myxosarcoma: a rare primary cardiac tumor. ( 12517027 )
2002
31
Cardiac myxoma and myxosarcoma: clinical experience and immunohistochemistry. ( 12079962 )
2002
32
Nasopharyngeal myxosarcoma in a Bengal tiger (Panthera tigris). ( 12564536 )
2002
33
Left atrial myxosarcoma with systemic metastasis: a case report. ( 11289388 )
2001
34
Right atrial myxosarcoma in a dog. ( 9561500 )
1997
35
Primary left atrial myxosarcoma. ( 7691044 )
1993
36
Surgical treatment of pulmonary artery primary myxosarcoma. ( 8599076 )
1993
37
Intestinal myxosarcoma in a thoroughbred mare. ( 1623729 )
1992
38
Myxosarcoma in a Sinaloan milksnake. ( 1813474 )
1991
39
Myxosarcoma in a dog. ( 12684949 )
1990
40
Cytogenetic analysis of a gossypol-induced murine myxosarcoma. ( 3473256 )
1987
41
A case of malignant myxoma (myxosarcoma) of the maxilla. ( 6591371 )
1984
42
Myxosarcoma in a wapiti. ( 480522 )
1979
43
Primary cardiac myxosarcoma in a child. ( 423607 )
1979
44
Myxosarcoma in a young rhesus monkey. ( 809897 )
1975
45
Recurrent myxosarcoma of left atrium. ( 1126234 )
1975
46
Spontaneous myxosarcoma in a cottontail rabbit (Sylvilagus floridanus): observation of tubular structures in the endoplasmic reticulum of tumor cells. ( 4737213 )
1973
47
Myxosarcoma of the pulmonary valve. ( 5082046 )
1972
48
Myxosarcoma of the orbit (a case report). ( 15744961 )
1971
49
Primary myxosarcoma of leg. ( 4905664 )
1970
50
MYXOSARCOMA OF THE PENIS: A CASE REPORT. ( 14346457 )
1965

Variations for Myxosarcoma

Expression for Myxosarcoma

Search GEO for disease gene expression data for Myxosarcoma.

Pathways for Myxosarcoma

Pathways related to Myxosarcoma according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.85 ATM BRCA1 MDM2 TP53 VWF
2 12.38 ABCB1 ATM BRCA1 MDM2 TP53
3 12.35 ATM BRCA1 MDM2 NUDT1 TP53
4
Show member pathways
12.26 ATM BRCA1 MDM2 TP53
5
Show member pathways
12.12 ATM BRCA1 MDM2 TP53
6 12.02 ATM BRCA1 MDM2 TP53
7 11.86 ATM MDM2 TP53
8
Show member pathways
11.7 ATM BRCA1 TP53
9 11.68 NME1 NME2 TP53
10
Show member pathways
11.62 ATM MDM2 TP53
11
Show member pathways
11.61 ATM BRCA1 MDM2 TP53
12 11.56 ATM BRCA1 TP53
13 11.5 ATM MDM2 TP53
14 11.32 ATM BRCA1 MDM2 TP53
15 11.21 ATM BRCA1 TP53
16 11.16 BRCA1 MDM2 TP53
17 11.1 ATM BRCA1 TP53
18
Show member pathways
10.95 ATM MDM2 TP53
19 10.92 ATM BRCA1 MDM2 TP53
20 10.88 ABCB1 NME1 NME2
21 10.78 ATM BRCA1 TP53
22 10.73 NME1 NME2
23 10.69 ABCB1 TP53
24 10.69 ABCB1 NME1 NME2
25 10.57 ATM BRCA1 MDM2 TP53
26 10.48 NME1 NME2

GO Terms for Myxosarcoma

Cellular components related to Myxosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.02 BRCA1 MDM2 PRKAR1A S100A1 TP53

Biological processes related to Myxosarcoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.73 ATM MB MDM2 PRKAR1A
2 regulation of apoptotic process GO:0042981 9.65 ATM BRCA1 NME1 NME2 TP53
3 positive regulation of protein export from nucleus GO:0046827 9.57 MDM2 TP53
4 nucleoside diphosphate phosphorylation GO:0006165 9.56 NME1 NME2
5 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.55 BRCA1 TP53
6 DNA double-strand break processing GO:0000729 9.54 ATM BRCA1
7 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.54 ATM MDM2 TP53
8 CTP biosynthetic process GO:0006241 9.52 NME1 NME2
9 replicative senescence GO:0090399 9.51 ATM TP53
10 cellular response to organic substance GO:0071310 9.5 CD68 MDM2 SYP
11 determination of adult lifespan GO:0008340 9.49 ATM TP53
12 GTP biosynthetic process GO:0006183 9.48 NME1 NME2
13 UTP biosynthetic process GO:0006228 9.46 NME1 NME2
14 female meiotic nuclear division GO:0007143 9.4 ATM PRKAR1A
15 regulation of signal transduction by p53 class mediator GO:1901796 9.26 ATM BRCA1 MDM2 TP53
16 cellular response to actinomycin D GO:0072717 9.16 MDM2 TP53
17 cellular response to gamma radiation GO:0071480 8.8 ATM MDM2 TP53

Molecular functions related to Myxosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.62 BRCA1 MDM2 NME1 TP53
2 ubiquitin protein ligase binding GO:0031625 9.46 BRCA1 MDM2 PRKAR1A TP53
3 identical protein binding GO:0042802 9.43 MDM2 NME1 S100A1 SYP TP53 VWF
4 nucleoside diphosphate kinase activity GO:0004550 9.26 NME1 NME2
5 protein N-terminus binding GO:0047485 8.92 ATM MDM2 TP53 VWF

Sources for Myxosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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