MCID: NLD001
MIFTS: 53

Nail Disease

Categories: Bone diseases, Fetal diseases, Genetic diseases, Rare diseases, Skin diseases
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Aliases & Classifications for Nail Disease

Summaries for Nail Disease

MedlinePlus: 41 Your toenails and fingernails protect the tissues of your toes and fingers. They are made up of layers of a hardened protein called keratin, which is also in your hair and skin. The health of your nails can be a clue to your overall health. Healthy nails are usually smooth and consistent in color. Specific types of nail discoloration and changes in growth rate can be signs of lung, heart, kidney, and liver diseases, as well as diabetes and anemia. White spots and vertical ridges are harmless. Nail problems that sometimes require treatment include: Bacterial and fungal infections Ingrown nails Tumors Warts Keeping your nails clean, dry, and trimmed can help you avoid some problems. Do not remove the cuticle, which can cause infection.

MalaCards based summary: Nail Disease, also known as nail diseases, is related to spondyloarthropathy 1 and psoriasis 11, and has symptoms including pruritus, exanthema and clubbing of nail. An important gene associated with Nail Disease is FZD6 (Frizzled Class Receptor 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Tazarotene and Polihexanide have been mentioned in the context of this disorder. Affiliated tissues include nail, skin and lung, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

Disease Ontology: 11 An integumentary system disease that is located in nail.

Wikipedia: 75 A nail disease or onychosis is a disease or deformity of the nail. Although the nail is a structure... more...

Related Diseases for Nail Disease

Diseases in the Nail Disease family:

Nail Disorder, Nonsyndromic Congenital, 6 Nail Disorder, Nonsyndromic Congenital, 2
Nail Disorder, Nonsyndromic Congenital, 3 Nail Disorder, Nonsyndromic Congenital, 1
Nail Disorder, Nonsyndromic Congenital, 5 Nail Disorder, Nonsyndromic Congenital, 4
Nail Disorder, Nonsyndromic Congenital, 7 Nail Disorder, Nonsyndromic Congenital, 8
Nail Disorder, Nonsyndromic Congenital, 9 Nonsyndromic Congenital Nail Disorder

Diseases related to Nail Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 175)
# Related Disease Score Top Affiliating Genes
1 spondyloarthropathy 1 31.0 IL17F IL17A CCR6
2 psoriasis 11 30.9 IL17RA IL17F IL17A
3 nail disorder, nonsyndromic congenital, 1 30.8 FZD6 CCR6
4 psoriasis 30.5 STAT3 IL22 IL17RA IL17F IL17A CCR6
5 skin disease 29.9 STAT3 STAT1 IL22 IL17RA IL17F IL17A
6 immune deficiency disease 29.8 STAT1 IL17A IL12RB1 CCR6 AIRE
7 dermatophytosis 29.6 IL17F IL17A IL12RB1 CLEC7A CLEC6A CLEC4E
8 candidiasis 29.5 STAT3 STAT1 IL22 IL17RC IL17RA IL17F
9 chronic mucocutaneous candidiasis 28.7 ZNF341 STAT3 STAT1 IL22 IL17RC IL17RA
10 isolated nail anomaly 11.2
11 genetic nail anomaly 11.1
12 syndromic nail anomaly 11.1
13 nail disorder, nonsyndromic congenital, 3 11.0
14 yellow nail syndrome 11.0
15 nail disorder, nonsyndromic congenital, 7 11.0
16 nail dysplasia, isolated congenital 11.0
17 leukonychia totalis-acanthosis-nigricans-like lesions-abnormal hair syndrome 11.0
18 paronychia 11.0
19 tinea unguium 11.0
20 nonsyndromic congenital nail disorder 10.9
21 aspergillosis 10.4 STAT3 CLEC7A CCR6
22 trichosporonosis 10.4 CLEC7A CARD9
23 pustulosis of palm and sole 10.4 IL17F IL17A CCR6
24 autoimmune gastritis 10.4 IL17A CCR6 AIRE
25 inflammatory bowel disease 23 10.4 IL22 CCR6
26 ankylosing spondylitis 1 10.4 IL17RA IL17F IL17A
27 penicilliosis 10.4 IL12RB1 CLEC7A CARD9
28 tinea imbricata 10.4 CLEC7A CLEC6A CARD9
29 mucormycosis 10.4 CLEC7A CCR6 CARD9
30 exanthem 10.4 IL17A EGFR CCR6
31 autoimmune uveitis 10.4 IL17F IL17A CCR6
32 immunodeficiency 29 10.4 IL17RC IL12RB1 CARD9
33 candidal paronychia 10.4 IL17RC CLEC4E
34 psoriatic arthritis 10.4
35 acute generalized exanthematous pustulosis 10.4 IL22 IL17F IL17A
36 immunodeficiency 41 with lymphoproliferation and autoimmunity 10.4 STAT1 DOCK8 CCR6
37 extrapulmonary tuberculosis 10.4 IL17A IL12RB1 CCR6
38 sporotrichosis 10.4 CLEC7A CLEC6A CARD9
39 commensal bacterial infectious disease 10.3 SETBP1 IL17A CCR6
40 inflammatory bowel disease 1 10.3 IL17A CCR6 CARD9
41 folliculitis 10.3 IL17RA IL17A CCR6
42 coccidiosis 10.3 STAT1 IL17A CCR6
43 human cytomegalovirus infection 10.3 IL17A EGFR CCR6
44 t cell deficiency 10.3 IL17A DOCK8 CCR6
45 tinea cruris 10.3 CLEC6A CARD9
46 vitiligo-associated multiple autoimmune disease susceptibility 1 10.3 IL17A CCR6 AIRE
47 autoimmune disease of endocrine system 10.3 IL17A CCR6 AIRE
48 sebaceous gland disease 10.3 IL17A EGFR CCR6
49 nasopharyngitis 10.3 IL17RA IL17F IL17A CCR6
50 rectal disease 10.3 IL17A EGFR CCR6

Graphical network of the top 20 diseases related to Nail Disease:



Diseases related to Nail Disease

Symptoms & Phenotypes for Nail Disease

UMLS symptoms related to Nail Disease:


pruritus; exanthema; clubbing of nail

GenomeRNAi Phenotypes related to Nail Disease according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.23 CCR6 CLEC7A EGFR FZD6 IL17A IL17RC

MGI Mouse Phenotypes related to Nail Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.22 AIRE CARD9 CCR6 CLEC4E CLEC7A EGFR
2 immune system MP:0005387 10.06 AIRE CARD9 CCR6 CLEC4E CLEC6A CLEC7A
3 no phenotypic analysis MP:0003012 9.91 AIRE CLEC4E CLEC6A EGFR IL17A IL17RA
4 digestive/alimentary MP:0005381 9.86 AIRE CLEC7A EGFR IL17A IL17F IL22
5 respiratory system MP:0005388 9.61 AIRE CLEC7A EGFR IL17A IL17F IL17RA
6 hematopoietic system MP:0005397 9.55 AIRE CARD9 CCR6 CLEC4E CLEC6A CLEC7A

Drugs & Therapeutics for Nail Disease

Drugs for Nail Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tazarotene Approved, Investigational Phase 4 118292-40-3 5381
2
Polihexanide Approved, Investigational Phase 4 28757-47-3 20977
3
Ethanol Approved Phase 4 64-17-5 702
4
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
5
Acetaminophen Approved Phase 4 103-90-2 1983
6
Ibuprofen Approved Phase 4 15687-27-1 3672
7
Cathine Approved, Experimental, Illicit, Vet_approved, Withdrawn Phase 4 14838-15-4, 492-39-7 131954576 4786 26934
8
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
9
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
10
Ethyl chloride Approved, Experimental, Investigational Phase 4 75-00-3 6337
11 Keratolytic Agents Phase 4
12 Anti-Infective Agents Phase 4
13 Disinfectants Phase 4
14 Anti-Infective Agents, Local Phase 4
15 Hormones Phase 4
16 Hormone Antagonists Phase 4
17 Pharmaceutical Solutions Phase 4
18
Triamcinolone hexacetonide Phase 4
19
Triamcinolone diacetate Phase 4
20
Triamcinolone Acetonide Phase 4 6436
21 glucocorticoids Phase 4
22 Immunosuppressive Agents Phase 4
23 Immunologic Factors Phase 4
24 Analgesics Phase 4
25 Antirheumatic Agents Phase 4
26 Antipyretics Phase 4
27 Acetaminophen, hydrocodone drug combination Phase 4
28 Cyclooxygenase Inhibitors Phase 4
29 Anti-Inflammatory Agents, Non-Steroidal Phase 4
30 Respiratory System Agents Phase 4
31 Antitussive Agents Phase 4
32 Analgesics, Opioid Phase 4
33 Analgesics, Non-Narcotic Phase 4
34 Anti-Inflammatory Agents Phase 4
35 Narcotics Phase 4
36 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
37 Anesthetics, Local Phase 4
38 Anesthetics Phase 4
39
Docetaxel Approved, Investigational Phase 3 114977-28-5 148124
40
Amorolfine Approved, Investigational 78613-35-1
41
Itraconazole Approved, Investigational 84625-61-6 55283
42
Ciclopirox Approved, Investigational 29342-05-0 2749
43
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
44
Clotrimazole Approved, Vet_approved 23593-75-1 2812
45
Terbinafine Approved, Investigational, Vet_approved 91161-71-6 1549008
46 Dermatologic Agents
47 Antifungal Agents
48
Hydroxyitraconazole 108222
49 Cytochrome P-450 Enzyme Inhibitors
50 Cytochrome P-450 CYP3A Inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of Combined Fractional Carbon Dioxide Laser and Topical Tazarotene in the Treatment of Psoriatic: Nail Disease a Single-blind, Intrapatient Left-to-right Controlled Study. Unknown status NCT03263624 Phase 4 Tazarotene Cream 0.1%
2 Efficacy of Intraoperative Surgical Scrubbing in Reducing Bacterial Load After Nail Removal Surgery Completed NCT01330706 Phase 4 Polihexanide
3 Use of Platelet-rich Plasma (PRP) Therapy in Patients With Brittle Nail Syndrome Recruiting NCT04941807 Phase 4
4 Benefit of Placebo and Different Concentrations of Triamcinolone Acetonide in Nail Psoriasis Recruiting NCT03991936 Phase 4 Placebos;Triamcinolone Acetonide 2.5 mg/mL;Triamcinolone Acetonide 5.0 mg/mL;Triamcinolone Acetonide 7.5 mg/mL;Triamcinolone Acetonide 10 mg/mL
5 Analysis of Hydrocodone Compared to Acetaminophen and Ibuprofen for Post-nail Procedure Analgesia Not yet recruiting NCT05544734 Phase 4 Hydrocodone 5Mg/Acetaminophen 325Mg Tab;Acetaminophen 1000mg;Ibuprofen 400 mg
6 The Evaluation of External Thermomechanical Stimulation for Pain Reduction in Patients Undergoing Nail Injection Not yet recruiting NCT04422795 Phase 4 Ethyl chloride skin refrigerant spray
7 The Evaluation of Topical Hemostatic Powder Containing Hydrophilic Polymer With Potassium Ferrate for Hemostasis Following Nail Surgery Withdrawn NCT04384679 Phase 4
8 Randomized Trial Evaluating the Cryotherapy in the Prevention of Nails Toxicity Induced by Taxotere® in Patient Treated for Breast or Prostate Cancer. Completed NCT00925418 Phase 3
9 Subclinical Nail Involvement in Relevant Skin Diseases Unknown status NCT04092413
10 Pilot Study on the Evaluation of the Efficacy, Tolerability and Safety of Topical and Oral Antifungals in the Treatment of Onychomycosis and Creation of a Library of Dermatological Clinical Isolates Recruiting NCT05482763 Terbinafine Topical Gel;Itraconazole 200 mg;Terbinafine 250 mg;Ciclopirox Topical Gel;Amorolfine 50 MG/ML

Search NIH Clinical Center for Nail Disease

Cochrane evidence based reviews: nail diseases

Genetic Tests for Nail Disease

Genetic tests related to Nail Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Nail 28

Anatomical Context for Nail Disease

Organs/tissues related to Nail Disease:

FMA: Nail
MalaCards : Skin, Lung, Kidney, Liver, Heart, Prostate, Breast

Publications for Nail Disease

Articles related to Nail Disease:

(show top 50) (show all 526)
# Title Authors PMID Year
1
Diagnostic Utility of a Revised Formula-based Melanoma Discrimination Index for Nail Streaks in Dermoscopic Practice. 41
36472366 2022
2
Sustained Resolution of Nail Psoriasis Through 5 Years with Ixekizumab: A Post-Hoc analysis from UNCOVER-3. 41
36121210 2022
3
Clinical Clues to Differentiate between Dermatophyte Onychomycosis (DP-OM) and Dermatophytoma-Like Traumatic Onychodystrophy (DP-TO). 41
36119939 2022
4
Optimal diagnosis and management of common nail disorders. 62
35238267 2022
5
A Comprehensive Review of Platelet-Rich Plasma in the Treatment of Dermatologic Disorders. 62
36318219 2022
6
Systematic review of the prevalence of onychomycosis in children. 62
36130720 2022
7
An overview of psoriatic arthritis including clinical manifestations, assessment, diagnostic criteria, investigations, drug management and GRAPPA guidelines. 62
36356108 2022
8
Management of Nail Disease in Patients With Psoriatic Arthritis: An Updated Literature Review Informing the 2021 GRAPPA Treatment Recommendations. 62
36319021 2022
9
Prevalence, genetic diversity and antifungal susceptibility profiles of F. fujikuroi, F. solani and Fusarium incarnatum-equiseti species complexes from onychomycosis in north of Iran. 62
35775829 2022
10
Bacterial nanocellulose patches as a carrier for hydrating formulations to improve the topical treatment of nail diseases. 62
36209980 2022
11
Investigating the efficacy and safety of calcipotriol/betamethasone dipropionate foam and laser microporation for psoriatic nail disease-A hybrid trial using a smartphone application, optical coherence tomography, and patient-reported outcome measures. 62
36321647 2022
12
Radiological Imaging of Nail Disorders (PART II) - Radiological Features of Nail Disease. 62
36386741 2022
13
Sox9 Is Required for Nail-Bed Differentiation and Digit-Tip Regeneration. 62
35398376 2022
14
Novel and Investigational Treatments for Onychomycosis. 62
36294644 2022
15
Consensus statements for pharmacological management, monitoring of therapies, and comorbidity management of psoriatic arthritis in the United Arab Emirates. 62
35916205 2022
16
Secukinumab demonstrates high and sustained efficacy in nail psoriasis: post hoc analysis from phase III trials in patients with psoriatic arthritis. 62
35257363 2022
17
Real-world effectiveness and safety of tildrakizumab in long-term treatment of plaque psoriasis: Results from the non-interventional, prospective, multicentre study TILOT. 62
36066998 2022
18
Poor Antifungal Coverage for Onychomycosis in a Cross-Sectional Analysis of Medicaid Formularies. 62
36251605 2022
19
Nail lichen planus: A review of clinical presentation, diagnosis and therapy. 62
35272870 2022
20
Friction-Induced Skin Disorders-A Review. 62
35951433 2022
21
Epidemiology of Onychomycosis in Chinese Mainland: A 30-year Retrospective Study. 62
35819711 2022
22
Review of the literature on the efficacy and safety of a new cosmetic topical treatment containing Pistacia lentiscus and hyaluronic acid for the treatment of nail plate damages. 62
35962760 2022
23
Severe Psoriasis Presenting in 3-Year-Old Child With Nail Dystrophy: Response to Biologic Treatment. 62
35946980 2022
24
Relevant insights into onychomycosis' pathogenesis related to the effectiveness topical treatment. 62
35716926 2022
25
Nail involvement in autosomal recessive congenital ichthyosis. 62
35181410 2022
26
[Association of skin lesion severity with clinical features of psoriatic arthritis]. 62
35764561 2022
27
Impact of clinical domains other than arthritis on composite outcomes in psoriatic arthritis: comparison of treatment effects in the SEAM-PsA trial. 62
35863864 2022
28
Unequal relevance between different subtypes of fingernail psoriasis and psoriatic arthritis. 62
35182271 2022
29
Radiological Imaging in Nail Unit Disorders (Part I) - Modalities Used. 62
36262575 2022
30
Treatment of nail diseases in the emergency department. 62
34289796 2022
31
Secukinumab provides sustained improvement in nail psoriasis, signs and symptoms of psoriatic arthritis and low rate of radiographic progression in patients with concomitant nail involvement: 2-year results from the Phase III FUTURE 5 study. 62
34494957 2022
32
The epidemiology and etiology of onychomycosis in 2 laboratory centers affiliated to Tehran university of medical sciences during 2019-2020. 62
35765553 2022
33
Combination Therapy Should Be Reserved as Second-Line Treatment of Onychomycosis: A Systematic Review of Onychomycosis Clinical Trials. 62
35330281 2022
34
Oral antifungal therapies for toenail onychomycosis: a systematic review with network meta-analysis toenail mycosis: network meta-analysis. 62
32043906 2022
35
Being overweight is associated with not reaching low disease activity in women but not men with psoriatic arthritis. 62
33831180 2022
36
Witch Nails (Krt90whnl): A spontaneous mouse mutation affecting nail growth and development. 62
36374931 2022
37
Bart's syndrome associated with a disorder of sexual differentiation: An atypical presentation in a Cameroonian newborn. 62
35028143 2022
38
Clinical, dermoscopic, and histopathological evaluations of patients with nail disorders. 62
34806290 2022
39
Characterisation of the nail microbiome in psoriatic and nonpsoriatic patients with onychomycosis. 62
34549836 2022
40
Updated Perspectives on the Diagnosis and Management of Onychomycosis. 62
36133401 2022
41
Challenge of Nail Psoriasis: An Update Review. 62
34478047 2021
42
Psoriatic onycho-pachydermo periostitis (POPP): a case report treated successfully with IL-17 blockade and a literature review on characteristics, pathogenesis, and treatment. 62
33830360 2021
43
A questionnaire survey study on nail disease prevalence in patients under podologic foot care. 62
34743587 2021
44
Investigation of the Dual-Stage Method of Active Er:YLF Laser Drug Delivery Through the Nail and Laser-Induced Transformations of the Drug Extinction Spectrum. 62
33450786 2021
45
The Penetrance of Topical Nail Therapy: Limitations and Current Enhancements. 62
34538431 2021
46
Three-dimensional structure analysis of mouse nails using synchrotron radiation. 62
34002795 2021
47
Apremilast improves quality of life and ultrasonography parameters in patients with nail psoriasis: A prospective cohort study. 62
34390034 2021
48
Therapeutic Recommendations for the Treatment of Toenail Onychomycosis in the US. 62
34636509 2021
49
Nutrition and nail disease. 62
34785009 2021
50
Nail Peeling with Glycolic Acid 50%: A Prospective Study of 20 Cases. 62
34604324 2021

Variations for Nail Disease

ClinVar genetic disease variations for Nail Disease:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 FZD6 NM_003506.4(FZD6):c.1531C>T (p.Arg511Cys) SNV Pathogenic
30356 rs151339003 GRCh37: 8:104340634-104340634
GRCh38: 8:103328406-103328406
2 FZD6 NM_003506.4(FZD6):c.1750G>T (p.Glu584Ter) SNV Pathogenic
30355 rs151339002 GRCh37: 8:104342091-104342091
GRCh38: 8:103329863-103329863
3 POGZ NM_015100.4(POGZ):c.2771del (p.Pro924fs) DEL Pathogenic
523510 rs1553212868 GRCh37: 1:151378740-151378740
GRCh38: 1:151406264-151406264
4 SETBP1 NM_015559.3(SETBP1):c.2614G>A (p.Gly872Arg) SNV Likely Pathogenic
523513 rs1555706928 GRCh37: 18:42531919-42531919
GRCh38: 18:44951954-44951954
5 PKD1 NM_001009944.3(PKD1):c.226C>T (p.His76Tyr) SNV Uncertain Significance
523385 rs932577597 GRCh37: 16:2169369-2169369
GRCh38: 16:2119368-2119368
6 OFD1 NM_003611.3(OFD1):c.1999G>A (p.Ala667Thr) SNV Uncertain Significance
523463 rs1394450537 GRCh37: X:13778578-13778578
GRCh38: X:13760459-13760459

Expression for Nail Disease

Search GEO for disease gene expression data for Nail Disease.

Pathways for Nail Disease

Pathways related to Nail Disease according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 CARD9 CCR6 CLEC4E CLEC6A CLEC7A IL12RB1
2
Show member pathways
13.74 STAT3 STAT1 IL22 IL17RC IL17RA IL17A
3
Show member pathways
13.54 STAT3 IL22 IL17RC IL17RA IL17F IL17A
4
Show member pathways
13.28 STAT3 STAT1 IL22 IL17RC IL17RA IL17A
5
Show member pathways
13.22 IL22 IL17RC IL17RA IL17A IL12RB1 EGFR
6
Show member pathways
13.21 IL12RB1 IL17A IL17F IL17RA IL17RC IL22
7
Show member pathways
12.53 STAT3 STAT1 IL17A IL12RB1 EGFR
8
Show member pathways
12.49 STAT1 EGFR CLEC7A CLEC6A CLEC4E CARD9
9 12.45 STAT3 STAT1 IL17A CARD9
10
Show member pathways
12.44 STAT3 STAT1 IL17F IL17A IL12RB1 EGFR
11
Show member pathways
12.32 CLEC7A CLEC6A CLEC4E CARD9
12
Show member pathways
12.18 STAT3 IL17RC IL17RA IL17F IL17A
13 12.12 STAT3 STAT1 FZD6 EGFR
14
Show member pathways
12.09 STAT3 STAT1 IL22 IL12RB1
15
Show member pathways
12.07 IL17A IL17F IL17RA IL17RC
16 11.88 STAT3 STAT1 IL17F IL17A
17
Show member pathways
11.85 STAT3 STAT1 IL12RB1
18
Show member pathways
11.77 STAT3 STAT1 IL17F IL17A IL12RB1
19 11.76 STAT1 IL22 IL17A
20 11.71 IL22 IL17A IL12RB1 CCR6
21 11.49 STAT3 STAT1 IL22 IL17F IL17A
22
Show member pathways
11.42 STAT3 STAT1 EGFR
23
Show member pathways
11.4 STAT3 IL17RC IL17RA IL17F IL17A IL12RB1
24
Show member pathways
11.32 STAT3 STAT1 IL22 IL17F IL12RB1
25
Show member pathways
11.13 STAT3 STAT1 IL22 IL17RA IL17F IL17A
26 11.11 STAT3 STAT1 IL22
27 10.2 IL17RC IL17RA IL17A

GO Terms for Nail Disease

Biological processes related to Nail Disease according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 10.33 CARD9 CLEC4E CLEC6A CLEC7A IL17A IL17F
2 inflammatory response GO:0006954 10.3 CLEC7A IL17A IL17F IL17RA IL17RC IL22
3 cytokine-mediated signaling pathway GO:0019221 10.2 STAT3 STAT1 IL17RC IL12RB1
4 positive regulation of tumor necrosis factor production GO:0032760 10.16 STAT3 IL17A CLEC7A CARD9
5 positive regulation of cytokine production GO:0001819 10.1 IL17F CLEC6A CLEC4E CARD9
6 immune system process GO:0002376 10.02 IL17RA IL17F IL17A CLEC7A CLEC6A CLEC4E
7 defense response to fungus GO:0050832 10.01 IL17RC IL17RA IL17A CLEC6A
8 interleukin-17-mediated signaling pathway GO:0097400 9.91 IL17RA IL17F IL17A
9 response to yeast GO:0001878 9.89 CLEC7A CLEC6A
10 T-helper 17 type immune response GO:0072538 9.88 STAT3 IL17RA
11 granulocyte chemotaxis GO:0071621 9.88 IL17RC IL17RA
12 fibroblast activation GO:0072537 9.87 IL17RA IL17A
13 antifungal innate immune response GO:0061760 9.86 CARD9 CLEC4E CLEC6A CLEC7A
14 positive regulation of interleukin-23 production GO:0032747 9.85 IL17RA IL17A CLEC7A
15 regulation of interleukin-2 production GO:0032663 9.84 IL17F CARD9
16 positive regulation of antimicrobial peptide production GO:0002225 9.83 IL17F IL17A
17 detection of yeast GO:0001879 9.81 CLEC7A CLEC6A
18 positive regulation of chemokine (C-X-C motif) ligand 1 production GO:2000340 9.8 IL17RA IL17F IL17A
19 positive regulation of interleukin-6 production GO:0032755 9.8 STAT3 IL17RC IL17RA IL17F IL17A CLEC7A
20 positive regulation of T-helper 17 type immune response GO:2000318 9.76 IL12RB1 CLEC7A CLEC6A CARD9
21 biological process involved in interspecies interaction between organisms GO:0044419 9.61 CLEC6A CLEC4E
22 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.47 STAT3 IL17RC IL17RA IL17F IL17A CLEC7A

Molecular functions related to Nail Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-17 receptor activity GO:0030368 9.26 IL17RC IL17RA
2 pattern recognition receptor activity GO:0038187 9.1 CLEC7A CLEC6A CLEC4E

Sources for Nail Disease

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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