Nail Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: NLD001 MIFTS: 52	Nail Disease Categories: Bone diseases, Fetal diseases, Genetic diseases, Rare diseases, Skin diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Nail Disease

MalaCards integrated aliases for Nail Disease:

Name: Nail Disease ¹² ⁶ ¹⁵

Nail Diseases ⁴² ⁴⁴ ⁷⁰

Abnormality of the Nail ²⁹ ⁶

Nail Anomaly ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases Fetal diseases
Anatomical: Skin diseases Bone diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the skin and subcutaneous tissue

Disorders of skin appendages

Nail disorders

Nail disorder, unspecified

Nail disorders in diseases classified elsewhere

Nail disorders in other diseases classified elsewhere

Orphanet: ⁵⁸

Rare skin diseases

External Ids:

Disease Ontology ¹² DOID:4123

ICD9CM ³⁴ 703

MeSH ⁴⁴ D009260

SNOMED-CT ⁶⁷ 17790008

ICD10 ³² L60 L60.9 L62 more

UMLS via Orphanet ⁷¹ C0265997 C0853087

Orphanet ⁵⁸ ORPHA79368

UMLS ⁷⁰ C0027339

Sources

Summaries for Nail Disease

MedlinePlus : ⁴² Your toenails and fingernails protect the tissues of your toes and fingers. They are made up of layers of a hardened protein called keratin, which is also in your hair and skin. The health of your nails can be a clue to your overall health. Healthy nails are usually smooth and consistent in color. Specific types of nail discoloration and changes in growth rate can be signs of lung, heart, kidney, and liver diseases, as well as diabetes and anemia. White spots and vertical ridges are harmless. Nail problems that sometimes require treatment include Bacterial and fungal infections Ingrown nails Tumors Warts Keeping your nails clean, dry, and trimmed can help you avoid some problems. Do not remove the cuticle, which can cause infection.

MalaCards based summary : Nail Disease, also known as nail diseases, is related to paronychia and nonsyndromic congenital nail disorder, and has symptoms including pruritus, exanthema and clubbing of nail. An important gene associated with Nail Disease is FZD6 (Frizzled Class Receptor 6), and among its related pathways/superpathways are ERK Signaling and Innate Immune System. The drugs Tazarotene and Polihexanide have been mentioned in the context of this disorder. Affiliated tissues include nail, skin and thymus, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Disease Ontology : ¹² An integumentary system disease that is located in nail.

Wikipedia : ⁷³ A nail disease or onychosis is a disease or deformity of the nail. Although the nail is a structure... more...

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Related Diseases for Nail Disease

Diseases in the Nail Disease family:

Nail Disorder, Nonsyndromic Congenital, 6	Nail Disorder, Nonsyndromic Congenital, 2
Nail Disorder, Nonsyndromic Congenital, 3	Nail Disorder, Nonsyndromic Congenital, 1
Nail Disorder, Nonsyndromic Congenital, 5	Nail Disorder, Nonsyndromic Congenital, 4
Nail Disorder, Nonsyndromic Congenital, 7	Nail Disorder, Nonsyndromic Congenital, 8
Nail Disorder, Nonsyndromic Congenital, 9	Nonsyndromic Congenital Nail Disorder

Diseases related to Nail Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 148)

#	Related Disease	Score	Top Affiliating Genes
1	paronychia	31.9	STAT1 EGFR
2	nonsyndromic congenital nail disorder	31.7	RSPO4 FZD6
3	psoriasis	30.3	STAT3 IL22 IL17F IL17A CCR6
4	skin disease	30.1	STAT3 IL22 IL17A EGFR CCR6
5	hair disease	30.1	IL17A EGFR CCR6 AIRE
6	dermatophytosis	29.6	STAT1 IL17A IL12RB1 CLEC7A CLEC6A CLEC4E
7	candidiasis	29.3	STAT3 STAT1 IL22 IL17RC IL17RA IL17F
8	chronic mucocutaneous candidiasis	28.6	STAT3 STAT1 IL22 IL17RC IL17RA IL17F
9	isolated nail anomaly	11.2
10	genetic nail anomaly	11.1
11	syndromic nail anomaly	11.1
12	tinea unguium	10.9
13	polyendocrinopathy	10.5	STAT1 AIRE
14	systemic autoimmune disease	10.4	IL17A AIRE
15	nail disorder, nonsyndromic congenital, 1	10.4	FZD6 CCR6 AIRE
16	ocular tuberculosis	10.4	RSPO4 FZD6
17	meningovascular neurosyphilis	10.4	IL17RA IL17A
18	penicilliosis	10.4	CLEC7A CARD9
19	vulvovaginal candidiasis	10.4	CLEC7A CCR6 CARD9
20	candidal paronychia	10.4	IL17RC CLEC4E
21	neonatal candidiasis	10.4	CLEC7A CLEC6A CARD9
22	candidiasis, familial, 2	10.4	CLEC7A CARD9
23	trichosporonosis	10.4	CLEC7A CLEC6A CARD9
24	commensal bacterial infectious disease	10.4	SETBP1 IL17A CCR6
25	tinea pedis	10.4	CLEC7A CLEC6A CARD9
26	ostertagiasis	10.4	CLEC7A CLEC4E
27	coccidiosis	10.4	STAT1 IL17A CCR6
28	rosacea	10.4	STAT1 IL17A CCR6
29	acute generalized exanthematous pustulosis	10.4	IL22 IL17F IL17A
30	immunodeficiency 29	10.4	IL17RC IL12RB1 CARD9
31	adenoiditis	10.4	CLEC7A CARD9
32	suppurative lymphadenitis	10.4	DOCK8 CCR6
33	fungal keratitis	10.4	CLEC7A CLEC4E
34	autoimmune enteropathy	10.4	STAT3 IL17A
35	nickel allergic contact dermatitis	10.4	IL22 IL17F IL17A
36	vitiligo-associated multiple autoimmune disease susceptibility 1	10.4	IL17A CCR6 AIRE
37	chickenpox	10.4	STAT1 DOCK8 CCR6
38	invasive aspergillosis	10.4	CLEC7A CLEC6A CCR6
39	t cell deficiency	10.4	IL17A DOCK8 CCR6
40	tinea cruris	10.4	CLEC6A CARD9
41	thymus gland disease	10.4	EGFR CCR6 AIRE
42	aspergillosis	10.4	STAT3 CLEC7A CCR6
43	salivary gland disease	10.3	SETBP1 EGFR CCR6
44	thymus cancer	10.3	EGFR CCR6 AIRE
45	ileitis	10.3	STAT3 IL17A CCR6
46	immunodeficiency 27b	10.3	STAT1 IL12RB1 DOCK8
47	sebaceous gland disease	10.3	IL17A EGFR CCR6
48	immunodeficiency 21	10.3	STAT1 IL12RB1 DOCK8
49	rectal disease	10.3	IL17A EGFR CCR6
50	autoimmune disease of endocrine system	10.3	IL17F IL17A CCR6 AIRE

Graphical network of the top 20 diseases related to Nail Disease:

Sources

Symptoms & Phenotypes for Nail Disease

UMLS symptoms related to Nail Disease:

pruritus; exanthema; clubbing of nail

GenomeRNAi Phenotypes related to Nail Disease according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Reduced mammosphere formation	GR00396-S	9.23	CCR6 CLEC7A EGFR FZD6 IL17A IL17RC

MGI Mouse Phenotypes related to Nail Disease:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.3	AIRE CARD9 CCR6 CLEC4E CLEC6A CLEC7A
2	homeostasis/metabolism	MP:0005376	10.2	AIRE CARD9 CCR6 CLEC4E CLEC7A EGFR
3	immune system	MP:0005387	10.16	AIRE CARD9 CCR6 CLEC4E CLEC6A CLEC7A
4	digestive/alimentary	MP:0005381	10.01	AIRE CLEC7A EGFR IL17A IL17F IL22
5	mortality/aging	MP:0010768	9.97	AIRE CLEC4E CLEC6A CLEC7A EGFR FZD6
6	no phenotypic analysis	MP:0003012	9.5	AIRE CLEC4E CLEC6A EGFR IL17A IL17RA
7	respiratory system	MP:0005388	9.28	AIRE CLEC7A EGFR IL17A IL17F IL17RA

Sources

Drugs & Therapeutics for Nail Disease

Drugs for Nail Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Tazarotene

Approved, Investigational

Phase 4

118292-40-3

5381

Synonyms:

118292-40-3

3-Pyridinecarboxylic acid, 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-, ethyl ester

3-Pyridinecarboxylic acid, 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-,ethyl ester

AC1L1K88

AC-755

AGN 190168

AGN-190168

Avage

Avage (TN)

BIDD:GT0293

C086827

C12531

C21H21NO2S

CHEBI:32184

CHEMBL1657

CID5381

D01132

DB00799

Ethyl 6-((4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate

ethyl 6-(2-(4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate

ethyl 6-[(4,4-dimethyl-3,4-dihydro-2H-thiochromen-6-yl)ethynyl]nicotinate

ethyl 6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylate

Fabior

I14-1992

LS-130838

MolPort-005-932-693

NCGC00167525-01

S1569_Selleck

S1684_Selleck

Suretin

tazarotene

Tazarotene

Tazarotène

Tazarotene (JAN/USAN/INN)

Tazarotene [USAN:INN]

tazaroteno

Tazaroteno

tazarotenum

Tazarotenum

Tazorac

Tazorac, Avage, Zora, Tazarotene

Tazoral

UNII-81BDR9Y8PS

ZINC01542199

Zorac

Polihexanide

Approved, Investigational

Phase 4

28757-47-3

Triamcinolone

Approved, Vet_approved

Phase 4

124-94-7

31307

Synonyms:

(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione

11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione

11b,16a,17a,21-Tetrahydroxy-9a-fluoro-1,4-pregnadiene-3,20-dione

11beta,16alpha,17alpha,21-Tetrahydroxy-9alpha-fluoro-1,4-pregnadiene-3,20-dione

11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione

11β,16α,17α,21-tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione

11Β,16α,17α,21-tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione

124-94-7

4-08-00-03629 (Beilstein Handbook Reference)

83474-03-7

9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy

9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione

9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d

9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione

9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone

9a-Fluoro-11b,16a,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9a-Fluoro-11b,16a,17a,21-tetrahydroxypregna-1,4-diene-3,20-dione

9a-Fluoro-16a-hydroxyprednisolone

9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione

9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9alpha-Fluoro-11beta,16alpha,17alpha,21-tetrahydroxypregna-1,4-diene-3,20-dione

9alpha-Fluoro-16alpha-hydroxyprednisolone

9-alpha-Fluoro-16-alpha-hydroxyprednisolone

9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9-Fluoro-11b,16a,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9α-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9Α-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione

9Α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione

9α-fluoro-16α-hydroxyprednisolone

9Α-fluoro-16α-hydroxyprednisolone

AC1L1LDH

AC1Q5HJC

AC-2072

Adcortyl

Aristocort

Aristocort A

Aristocort Tablets

Aristogel

Aristospan

Azmacort

Bio-0662

BPBio1_000154

BRD-K77554836-001-03-3

BRN 2341955

BSPBio_000140

C21H27FO6

Celeste

CHEMBL1451

CID31307

Cinolone

Cinolone-T

CL 19823

D00385

D014221

DB00620

Delphicort

droxypregna-1,4-diene-3,20-dione

EINECS 204-718-7

EU-0101179

Fluoxiprednisolone

Fluoxyprednisolone

Flutex

Fougera

HMS1568G22

HMS2090D12

HSDB 3194

ione

Kenacort

Kenacort (TN)

Kenacort-A

Kenacort-Ag

Kenacort-AG

Kenalog

Kenalog in Orabase

Kenalog-10

Kenalog-40

Kenalog-H

Ledercort

Lopac0_001179

LS-698

MLS000028542

MLS001066543

MLS002695935

MolPort-002-528-981

Mycolog

Nasacort

Nasacort Aq

Nasacort Hfa

NCGC00021580-03

NCGC00021580-04

NCGC00021580-05

NCGC00021580-06

NCGC00021580-07

nchembio.2007.53-comp7

NCI60_000750

NSC 13397

NSC13397

Omcilon

Omicilon

Oracort

Oralone

Orion

Polcortolon

Pregna-1,4-diene-3,20-dio

Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)

Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy- (8CI)

Prestwick_438

Prestwick0_000120

Prestwick1_000120

Prestwick2_000120

Prestwick3_000120

Rodinolone

S1933_Selleck

Sk-Triamcinolone

SK-Triamcinolone

SMP1_000300

SMR000058333

SPBio_002079

T6376_SIGMA

Tiamcinolonum

Tiamcinolonum [INN-Latin]

Triacet

Triacort

Triamcet

Triamcinalone

Triamcinlon

Triamcinolon

Triamcinolona

Triamcinolona [INN-Spanish]

triamcinolone

Triamcinolone

Triamcinolone (JP15/USP/INN)

TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7))

Triamcinolone [USAN:INN:BAN:JAN]

Triamcinolone acetonide

Triamcinolone diacetate

Triamcinolone hexacetonide

Triamcinolonum

Triamcinolonum [INN]

Triam-Tablinen

Triatex

Tricortale

Triderm

Trilone

Tri-Nasal

Tristoject

Trymex

UNII-1ZK20VI6TY

Vetalog

Volon

Volon A

WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ GQ

ZINC03882036

Ethyl chloride

Approved, Experimental, Investigational

Phase 4

75-00-3

Dermatologic Agents

Phase 4

Keratolytic Agents

Phase 4

Anti-Infective Agents, Local

Phase 4

Anti-Infective Agents

Phase 4

Disinfectants

Phase 4

Pharmaceutical Solutions

Phase 4

Hormones

Phase 4

Triamcinolone diacetate

Phase 4

Immunosuppressive Agents

Phase 4

Triamcinolone hexacetonide

Phase 4

Hormone Antagonists

Phase 4

triamcinolone acetonide

Phase 4

Anti-Inflammatory Agents

Phase 4

glucocorticoids

Phase 4

Immunologic Factors

Phase 4

Anesthetics

Phase 4

Anesthetics, Local

Phase 4

Hemostatics

Phase 4

Docetaxel

Approved, Investigational

Phase 3

114977-28-5

148124

Synonyms:

(2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl (aR,bS)-b-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxybenzenepropanoate

01885_FLUKA

114977-28-5

4-(acetyloxy)-13alpha-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7beta,10beta-trihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate

AC1L3WHJ

AC-383

ANX-514

BIND-014

C11231

CHEBI:4672

CHEMBL92

CID148124

D07866

DB01248

docetaxel

Docetaxel

Docetaxel (INN)

docetaxel 114977-28-5

Docetaxel anhydrous

Docetaxel hydrate

Docetaxel trihydrate

Docetaxel, trihydrate

Docetaxel, Trihydrate

Docetaxol

EmDOC

HMS2089K08

InChI=1/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,5

MolPort-003-847-005

N Debenzoyl N tert butoxycarbonyl 10 deacetyltaxol

nchembio.188-comp8

nchembio.2007.34-comp7

nchembio.573-comp11

nchembio853-comp8

N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel

N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel

N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol

N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol

N-debenzoyl-N-Boc-10-deacetyl taxol

N-Debenzoyl-N-tert-butoxycarbonyl-10-deacetyltaxol

NSC-628503

PSMA-targeted docetaxel nanoparticle

RP-56976

SDP-014

Taxoltere metro

Taxotere

Taxotere (TN)

Taxotere(R)

TXL

XRP-6976L

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Efficacy of Combined Fractional Carbon Dioxide Laser and Topical Tazarotene in the Treatment of Psoriatic: Nail Disease a Single-blind, Intrapatient Left-to-right Controlled Study.	Unknown status	NCT03263624	Phase 4	Tazarotene Cream 0.1%
2	Efficacy of Intraoperative Surgical Scrubbing in Reducing Bacterial Load After Nail Removal Surgery	Completed	NCT01330706	Phase 4	Polihexanide
3	Benefit of Placebo and Different Concentrations of Triamcinolone Acetonide in Nail Psoriasis	Recruiting	NCT03991936	Phase 4	Placebos;Triamcinolone Acetonide 2.5 mg/mL;Triamcinolone Acetonide 5.0 mg/mL;Triamcinolone Acetonide 7.5 mg/mL;Triamcinolone Acetonide 10 mg/mL
4	The Evaluation of External Thermomechanical Stimulation for Pain Reduction in Patients Undergoing Nail Injection	Not yet recruiting	NCT04422795	Phase 4	Ethyl chloride skin refrigerant spray
5	The Evaluation of Topical Hemostatic Powder Containing Hydrophilic Polymer With Potassium Ferrate for Hemostasis Following Nail Surgery	Not yet recruiting	NCT04384679	Phase 4
6	Randomized Trial Evaluating the Cryotherapy in the Prevention of Nails Toxicity Induced by Taxotere® in Patient Treated for Breast or Prostate Cancer.	Completed	NCT00925418	Phase 3
7	Subclinical Nail Involvement in Relevant Skin Diseases	Not yet recruiting	NCT04092413

Search NIH Clinical Center for Nail Disease

Cochrane evidence based reviews: nail diseases

Sources

Genetic Tests for Nail Disease

Genetic tests related to Nail Disease:

#	Genetic test	Affiliating Genes
1	Abnormality of the Nail ²⁹

Sources

Anatomical Context for Nail Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Nail Disease:

¹⁹

Nail

MalaCards organs/tissues related to Nail Disease:

⁴⁰

Skin, Thymus, Salivary Gland, Breast, Prostate, Cervix, Tongue

Sources

Publications for Nail Disease

Articles related to Nail Disease:

(show top 50) (show all 463)

#	Title	Authors	PMID	Year
1	One year in review 2019: psoriatic arthritis. ⁴²	Calabresi E...Carli L	33253102	2020
2	Diagnosis of Subungual Glomus Tumors with 18 MHz Ultrasound and CDFI. ⁴²	Chen L...Jiang LX	33082509	2020
3	Social media and dissemination: impressions of fish pedicures following a case of onychomadesis. ⁴²	Kang R...Lipner S	32815700	2020
4	Management of Nail Psoriasis. ⁶¹	Rigopoulos D...Gregoriou S	33745634	2021
5	Dermoscopy of the Nail Unit. ⁶¹	Starace M...Piraccini BM	33745641	2021
6	Nail Surgery: Six Essential Techniques. ⁶¹	Baltz JO...Jellinek NJ	33745642	2021
7	Pathology of the Nail Unit. ⁶¹	Ruben BS	33745643	2021
8	Onychoscopy: a quick and effective tool for diagnosing onychomycosis in a resource-poor setting. ⁶¹	Hazarika N...Bahurupi Y	33765751	2021
9	Race reporting and representation in onychomycosis clinical trials: A systematic review. ⁶¹	Chang MJ...Lipner SR	33655595	2021
10	Validation of a lateral flow immunochromatographic assay for tinea unguium diagnosis. ⁶¹	Tsuboi R...Maruyama R	33686693	2021
11	Nail Psoriasis: Diagnosis, Assessment, Treatment Options, and Unmet Clinical Needs. ⁶¹	Kaeley GS...Bakewell CJ	33589557	2021
12	Direct examination, histopathology and fungal culture for the diagnosis of onychomycosis: A retrospective, comparative study on 2245 specimens. ⁶¹	Lecerf P...Andre J	33075162	2021
13	Iontophoresis to Overcome the Challenge of Nail Permeation: Considerations and Optimizations for Successful Ungual Drug Delivery. ⁶¹	Chen K...Michniak-Kohn B	33439400	2021
14	Investigation of the Dual-Stage Method of Active Er:YLF Laser Drug Delivery Through the Nail and Laser-Induced Transformations of the Drug Extinction Spectrum. ⁶¹	Belikov AV...Smirnov SN	33450786	2021
15	Nail Disease: Clinical Decisions among Portuguese Dermatologists and Family Physicians. ⁶¹	Monteiro AF...Lencastre A	33614712	2021
16	Case Report: Coral Reef Pathogen Aspergillus sydowii Causing Black Grain Mycetoma: A Review. ⁶¹	Vera-Cabrera L...Ocampo-Candiani J	33399044	2021
17	Management of nail psoriasis. ⁶¹	Thomas L...Takwale A	32741010	2021
18	Axial psoriatic arthritis: An update for dermatologists. ⁶¹	Gottlieb AB...Merola JF	32747079	2021
19	Nail Changes in Lichen Planus: A Single-Center Study. ⁶¹	Zychowska M...Zychowska M	33336579	2020
20	The change of causative pathogens in toenail onychomycosis. ⁶¹	Akpinar Kara Y	33179427	2020
21	Safety of current therapies for onychomycosis. ⁶¹	Ricardo JW...Lipner SR	32990062	2020
22	Psoriatic arthritis for dermatologists. ⁶¹	Gottlieb A...Merola JF	31014154	2020
23	Psoriatic arthritis and depressive symptoms: does systemic inflammation play a role? ⁶¹	De Lorenzis E...Gremese E	33009969	2020
24	Association of Nail Psoriasis With Disease Activity Measures and Impact in Psoriatic Arthritis: Data From the Corrona Psoriatic Arthritis/Spondyloarthritis Registry. ⁶¹	Mease PJ...Ogdie A	33060307	2020
25	Prevalence of extra-articular manifestations in psoriatic arthritis: a systematic review and meta-analysis. ⁶¹	Pittam B...Zhao SS	32160297	2020
26	Perceptions Surrounding Onychomycosis in the Health Professions Student Population: The Disease, Treatments, and Quality of Life. ⁶¹	Martucci J...Vlahovic TC	33179067	2020
27	Assessment of internet sources on subungual melanoma. ⁶¹	Kang R...Lipner S	30169432	2020
28	Dermoscopic Features of Nail Psoriasis: An Observational, Analytical Study. ⁶¹	Chauhan A...Sharma S	32903967	2020
29	Pemphigus vegetans with paronychia-like changes resistant to rituximab therapy. ⁶¹	Ayoubi N...Motaparthi K	32367637	2020
30	The musculoskeletal impairment negatively impacts the quality of life of children and adolescents with psoriasis. ⁶¹	Meneghetti TC...de Carvalho VO	32552795	2020
31	Combination of toenail thinning and photodynamic therapy in distal and lateral subungual onychomycosis treatment: A case report. ⁶¹	Guo J...Zhang J	32109622	2020
32	Trachyonychia: a retrospective study of 122 patients in a period of 30 years. ⁶¹	Starace M...Piraccini BM	31923322	2020
33	Mixed Infection of Toe Nail Caused by Trichosporon asahii and Rhodotorula mucilaginosa. ⁶¹	Idris NFB...Tu Z	31760556	2020
34	Clinical improvement in psoriatic nail disease and psoriatic arthritis with tildrakizumab treatment. ⁶¹	Ismail FF...Sinclair R	31899569	2020
35	Oral antifungal therapies for toenail onychomycosis: a systematic review with network meta-analysis toenail mycosis: network meta-analysis. ⁶¹	Favero MLD...Pontarolo R	32043906	2020
36	Optical coherence tomography of onychomycosis: proposed terminology and a suggestion of practical usage. ⁶¹	Olsen J...Saunte DML	31595307	2020
37	Clinical Observation and Follow-Up of Subungual Splinter Hemorrhages of Toenails in Chinese Adults. ⁶¹	Gao J...Yang C	32029933	2020
38	An Open Study to Evaluate Effectiveness and Tolerability of a Nail Oil Composed of Vitamin E and Essential Oils in Mild to Moderate Distal Subungual Onychomycosis. ⁶¹	Alessandrini A...Piraccini BM	32021856	2020
39	Formulations Based on Natural Ingredients for the Treatment of Nail Diseases. ⁶¹	Tampucci S...Monti D	31969086	2020
40	Impact of Having Family History of Psoriasis or Psoriatic Arthritis on Psoriatic Disease. ⁶¹	Solmaz D...Aydin SZ	30680951	2020
41	Onychoscopy with red light for vascular pattern identification: a study of 33 patients. ⁶¹	Pellacani G...Starace M	31287600	2019
42	Emerging drugs for the treatment of onychomycosis. ⁶¹	Gupta AK...Stec N	31652088	2019
43	Fractional carbon dioxide laser and topical tioconazole in the treatment of fingernail onychomycosis. ⁶¹	El-Tatawy RA...Shams Eldeen MA	31025207	2019
44	Adalimumab for nail psoriasis: efficacy and safety over 52 weeks from a phase-3, randomized, placebo-controlled trial. ⁶¹	Elewski BE...Rich PA	31304993	2019
45	A Double Case of Nail-Patella Syndrome in the Same Family: The Importance of Nail Changes as Diagnostic Clues for Renal Involvement. ⁶¹	Starace M...Piraccini BM	31799274	2019
46	The ambulatory care burden of nail conditions in the United States. ⁶¹	Lipner SR...Fleischer AB	31613182	2019
47	Paclitaxel-related nail toxicity. ⁶¹	Yang ST...Wang PH	31542098	2019
48	The use of ultrasonography in the diagnosis of nail disease among patients with psoriasis and psoriatic arthritis: a systematic review. ⁶¹	Mendonca JA...D'Agostino MA	31488208	2019
49	Disease burden and treatment challenges of psoriatic arthritis in Africa and the Middle East. ⁶¹	Bedaiwi M...Al Saleh J	31134289	2019
50	Should Methotrexate Have Any Place in the Treatment of Psoriatic Arthritis? ⁶¹	Ye W...Coates LC	31277747	2019

Sources

Genes for Nail Disease

Genes related to Nail Disease (2 elite genes):

(show all 35)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	FZD6	Frizzled Class Receptor 6	Protein Coding	412.35	Pathogenic ⁶ DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
2	POGZ	Pogo Transposable Element Derived With ZNF Domain	Protein Coding	400	Pathogenic ⁶
3	SETBP1	SET Binding Protein 1	Protein Coding	25	Likely pathogenic ⁶
4	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	12.04	DISEASES inferred ¹⁵ ¹⁵
5	AIRE	Autoimmune Regulator	Protein Coding	8.69	DISEASES inferred ¹⁵
6	CARD9	Caspase Recruitment Domain Family Member 9	Protein Coding	8.19	DISEASES inferred ¹⁵
7	IL17F	Interleukin 17F	Protein Coding	8.03	DISEASES inferred ¹⁵
8	IL17RA	Interleukin 17 Receptor A	Protein Coding	7.94	DISEASES inferred ¹⁵
9	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	7.94	DISEASES inferred ¹⁵
10	IL17A	Interleukin 17A	Protein Coding	7.87	DISEASES inferred ¹⁵
11	CLEC7A	C-Type Lectin Domain Containing 7A	Protein Coding	7.61	DISEASES inferred ¹⁵
12	IL12RB1	Interleukin 12 Receptor Subunit Beta 1	Protein Coding	7.27	DISEASES inferred ¹⁵
13	CLEC6A	C-Type Lectin Domain Containing 6A	Protein Coding	7.2	DISEASES inferred ¹⁵
14	IL17RC	Interleukin 17 Receptor C	Protein Coding	7.16	DISEASES inferred ¹⁵
15	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	7	DISEASES inferred ¹⁵
16	IL22	Interleukin 22	Protein Coding	6.93	DISEASES inferred ¹⁵
17	DOCK8	Dedicator Of Cytokinesis 8	Protein Coding	6.85	DISEASES inferred ¹⁵
18	CLEC4E	C-Type Lectin Domain Family 4 Member E	Protein Coding	6.83	DISEASES inferred ¹⁵
19	EGFR	Epidermal Growth Factor Receptor	Protein Coding	6.63	DISEASES inferred ¹⁵
20	RSPO4	R-Spondin 4	Protein Coding	6.58	DISEASES inferred ¹⁵
21	CD4	CD4 Molecule	Protein Coding	6.48	DISEASES inferred ¹⁵
22	TRAF3IP2	TRAF3 Interacting Protein 2	Protein Coding	6.37	DISEASES inferred ¹⁵
23	IFNA1	Interferon Alpha 1	Protein Coding	6.28	DISEASES inferred ¹⁵
24	TYK2	Tyrosine Kinase 2	Protein Coding	6.26	DISEASES inferred ¹⁵
25	IL6	Interleukin 6	Protein Coding	6.17	DISEASES inferred ¹⁵
26	RORC	RAR Related Orphan Receptor C	Protein Coding	6.16	DISEASES inferred ¹⁵
27	TNF	Tumor Necrosis Factor	Protein Coding	6.1	DISEASES inferred ¹⁵
28	IL23A	Interleukin 23 Subunit Alpha	Protein Coding	6.07	DISEASES inferred ¹⁵
29	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	6.03	DISEASES inferred ¹⁵
30	CCRL2	C-C Motif Chemokine Receptor Like 2	Protein Coding	6.02	DISEASES inferred ¹⁵
31	NLRP5	NLR Family Pyrin Domain Containing 5	Protein Coding	6	DISEASES inferred ¹⁵
32	IL25	Interleukin 25	Protein Coding	5.98	DISEASES inferred ¹⁵
33	IL23R	Interleukin 23 Receptor	Protein Coding	5.96	DISEASES inferred ¹⁵
34	CD8A	CD8a Molecule	Protein Coding	5.92	DISEASES inferred ¹⁵
35	BCL10	BCL10 Immune Signaling Adaptor	Protein Coding	5.9	DISEASES inferred ¹⁵

Sources

Variations for Nail Disease

ClinVar genetic disease variations for Nail Disease:

⁶

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	FZD6	NM_003506.4(FZD6):c.1531C>T (p.Arg511Cys)	SNV	Pathogenic	30356	rs151339003	GRCh37: 8:104340634-104340634 GRCh38: 8:103328406-103328406
2	FZD6	NM_003506.4(FZD6):c.1750G>T (p.Glu584Ter)	SNV	Pathogenic	30355	rs151339002	GRCh37: 8:104342091-104342091 GRCh38: 8:103329863-103329863
3	POGZ	NM_015100.4(POGZ):c.2771del (p.Pro924fs)	Deletion	Pathogenic	523510	rs1553212868	GRCh37: 1:151378740-151378740 GRCh38: 1:151406264-151406264
4	SETBP1	NM_015559.3(SETBP1):c.2614G>A (p.Gly872Arg)	SNV	Likely pathogenic	523513	rs1555706928	GRCh37: 18:42531919-42531919 GRCh38: 18:44951954-44951954
5	PKD1	NM_001009944.3(PKD1):c.226C>T (p.His76Tyr)	SNV	Uncertain significance	523385	rs932577597	GRCh37: 16:2169369-2169369 GRCh38: 16:2119368-2119368
6	OFD1	NM_003611.3(OFD1):c.1999G>A (p.Ala667Thr)	SNV	Uncertain significance	523463	rs1394450537	GRCh37: X:13778578-13778578 GRCh38: X:13760459-13760459

Sources

Expression for Nail Disease

Search GEO for disease gene expression data for Nail Disease.

Sources

Pathways for Nail Disease

Pathways related to Nail Disease according to GeneCards Suite gene sharing:

(show all 24)

#	Super pathways	Score	Top Affiliating Genes
1	ERK Signaling ⁶³ Show member pathways ILK Signaling ⁶³ MAPK Signaling ⁶³ Molecular Mechanisms of Cancer ⁶³ Rho Family GTPases ⁶³	13.73	STAT3 STAT1 IL22 IL17RC IL17RA IL17A
2	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.59	STAT3 STAT1 IL22 IL17RC IL17RA IL17F
3	PEDF Induced Signaling ⁶³ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶³ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶³ Glucocorticoid Receptor Signaling ⁶³ IL-6 Pathway ⁶³ MIF Mediated Glucocorticoid Regulation ⁶³ MIF Regulation of Innate Immune Cells ⁶³ NFAT Signaling and Lymphocyte Interactions ⁶³ PGC1Alpha Pathway ⁶³ RAR-Gamma-RXR-Alpha Degradation ⁶³ STAT3 Pathway ⁶³	13.58	STAT3 IL22 IL17RC IL17RA IL17F IL17A
4	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.26	STAT3 STAT1 IL22 IL17RC IL17RA IL17A
5	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.2	IL22 IL17RC IL17RA IL17A IL12RB1 EGFR
6	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.08	STAT3 STAT1 IL22 IL17RC IL17RA IL17F
7	Pathways in cancer ³⁶	12.73	STAT3 STAT1 IL12RB1 FZD6 EGFR
8	Th17 cell differentiation ³⁶ Show member pathways IL-22 Pathway ⁶³ Immune response IL-22 signaling pathway ²³ Inflammatory bowel disease ³⁶ Th1 and Th2 cell differentiation ³⁶	12.38	STAT3 STAT1 IL22 IL17F IL17A IL12RB1
9	CLEC7A (Dectin-1) signaling ⁶⁵ Show member pathways Alternative NF-kappaB pathway ¹ CLEC7A/inflammasome pathway ⁶⁵ C-type lectin receptors (CLRs) ⁶⁵	12.32	CLEC7A CLEC6A CLEC4E CARD9
10	JAK-STAT signaling pathway ³⁶ Show member pathways B-Cell Development ⁶³ IL-7 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴ Interleukin-19, 20, 22, 24 ⁶⁵ Jak/STAT Signaling Pathway ⁶⁴ Type III interferon signaling ¹	12.32	STAT3 STAT1 IL22 IL12RB1 EGFR
11	Immune response IL-23 signaling pathway ²³ Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶³ Development Angiopoietin - Tie2 signaling ²³ Development PDGF signaling via STATs and NF-kB ²³ IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²³ Rac1/Pak1/p38/MMP-2 pathway ¹	12.27	STAT3 STAT1 IL17F IL17A IL12RB1 EGFR
12	IL-17 Family Signaling Pathways ⁶⁴ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁶ Interleukin-17 signaling ⁶⁵ Mucin expression in CF via IL-6, IL-17 signaling pathways ²³	12.23	STAT3 IL17RC IL17RA IL17F IL17A
13	Tuberculosis ³⁶	12.13	STAT1 CLEC7A CLEC4E CARD9
14	Colorectal Cancer Metastasis ⁶³	12.09	STAT3 STAT1 FZD6 EGFR
15	C-type lectin receptor signaling pathway ³⁶ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁴	12.04	STAT1 CLEC7A CLEC6A CLEC4E CARD9
16	Interleukin-4 and 13 signaling ⁶⁵	11.89	STAT3 STAT1 IL17F IL17A
17	ErbB1 downstream signaling ¹	11.8	STAT3 STAT1 EGFR
18	Innate Lymphoid Cell Differentiation Pathways ⁶⁴	11.68	IL22 IL17A IL12RB1 CCR6
19	Th1 Differentiation Pathway ⁶⁴ Show member pathways IL27-mediated signaling events ¹	11.61	STAT3 STAT1 IL17A IL12RB1
20	AGE/RAGE pathway ¹	11.59	STAT3 STAT1 EGFR
21	Cytokine production by Th17 cells in CF (Mouse model) ²³ Show member pathways Cytokine production by Th17 cells in CF ²³	11.4	STAT3 IL17RC IL17RA IL17F IL17A IL12RB1
22	Signaling events mediated by TCPTP ¹	11.28	STAT3 STAT1 EGFR
23	Th17 Differentiation Pathway ⁶⁴ Show member pathways IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴	11.13	STAT3 STAT1 IL22 IL17RA IL17F IL17A
24	EGF receptor (ErbB1) signaling pathway ¹	11.08	STAT3 STAT1 EGFR

Sources

GO Terms for Nail Disease

Biological processes related to Nail Disease according to GeneCards Suite gene sharing:

(show all 24)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	10.1	STAT3 STAT1 POGZ IL17F IL17A EGFR
2	immune system process	GO:0002376	10.04	IL17RA IL17F IL17A CLEC7A CLEC6A CLEC4E
3	innate immune response	GO:0045087	9.95	IL17RA IL17F IL17A CLEC7A CLEC6A CLEC4E
4	inflammatory response	GO:0006954	9.91	STAT3 IL22 IL17RC IL17RA IL17F IL17A
5	cytokine-mediated signaling pathway	GO:0019221	9.8	STAT3 STAT1 IL22 IL17RC IL17F IL17A
6	defense response to Gram-positive bacterium	GO:0050830	9.79	IL17F IL17A CARD9
7	cellular response to cytokine stimulus	GO:0071345	9.74	STAT3 STAT1 IL17RA
8	positive regulation of tumor necrosis factor production	GO:0032760	9.73	STAT3 IL17A CLEC7A CARD9
9	positive regulation of interleukin-1 beta production	GO:0032731	9.72	STAT3 IL17A CLEC7A
10	defense response to fungus	GO:0050832	9.69	IL17RC IL17A CLEC6A
11	regulation of interleukin-6 production	GO:0032675	9.61	IL17F CARD9
12	interleukin-35-mediated signaling pathway	GO:0070757	9.61	STAT3 STAT1
13	interleukin-27-mediated signaling pathway	GO:0070106	9.6	STAT3 STAT1
14	interleukin-23-mediated signaling pathway	GO:0038155	9.59	STAT3 IL12RB1
15	interleukin-9-mediated signaling pathway	GO:0038113	9.58	STAT3 STAT1
16	interleukin-21-mediated signaling pathway	GO:0038114	9.58	STAT3 STAT1
17	positive regulation of interleukin-23 production	GO:0032747	9.54	IL17RA IL17A
18	fibroblast activation	GO:0072537	9.52	IL17RA IL17A
19	positive regulation of chemokine (C-X-C motif) ligand 1 production	GO:2000340	9.5	IL17RA IL17F IL17A
20	regulation of interleukin-2 production	GO:0032663	9.48	IL17F CARD9
21	positive regulation of antimicrobial peptide production	GO:0002225	9.46	IL17F IL17A
22	interleukin-17-mediated signaling pathway	GO:0097400	9.46	IL17RC IL17RA IL17F IL17A
23	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.35	STAT3 IL17RC IL17F IL17A CLEC7A
24	positive regulation of interleukin-6 production	GO:0032755	9.17	STAT3 IL17RC IL17RA IL17F IL17A CLEC7A

Molecular functions related to Nail Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	10.13	STAT3 STAT1 SETBP1 RSPO4 POGZ IL22
2	pattern recognition receptor activity	GO:0038187	9.26	CLEC7A CLEC4E
3	CCR5 chemokine receptor binding	GO:0031730	8.96	STAT3 STAT1
4	interleukin-17 receptor activity	GO:0030368	8.62	IL17RC IL17RA

Sources

Sources for Nail Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia