Nail Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: NLD001 MIFTS: 53	Nail Disease Categories: Bone diseases, Fetal diseases, Genetic diseases, Rare diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
Genes Variations Tissues Related diseases Publications Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Nail Disease

MalaCards integrated aliases for Nail Disease:

Name: Nail Disease ¹¹ ⁵ ¹⁴ ⁷⁵

Nail Diseases ⁴¹ ⁴³ ⁷¹

Abnormality of the Nail ²⁸ ⁵

Nail Anomaly ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases Fetal diseases
Anatomical: Skin diseases Bone diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Diseases of the skin and subcutaneous tissue

Disorders of skin appendages

Nail disorders

Nail disorder, unspecified

Nail disorders in diseases classified elsewhere

Nail disorders in other diseases classified elsewhere

ICD11: ³³

Diseases of the skin

Skin disorders involving specific cutaneous structures

Disorders of the epidermis and epidermal appendages

Disorders of the nail or perionychium

Certain disorders affecting the nails or perionychium

Other specified nail disorder

Orphanet: ⁵⁸

Rare skin diseases

External Ids:

Disease Ontology ¹¹ DOID:4123

ICD9CM ³⁴ 703

MeSH ⁴³ D009260

SNOMED-CT ⁶⁸ 17790008

ICD10 ³¹ L60 L60.9 L62 more

UMLS via Orphanet ⁷² C0265997 C0853087

Orphanet ⁵⁸ ORPHA79368

ICD11 ³³ 1851131352/other

UMLS ⁷¹ C0027339

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Summaries for Nail Disease

MedlinePlus: ⁴¹ Your toenails and fingernails protect the tissues of your toes and fingers. They are made up of layers of a hardened protein called keratin, which is also in your hair and skin. The health of your nails can be a clue to your overall health. Healthy nails are usually smooth and consistent in color. Specific types of nail discoloration and changes in growth rate can be signs of lung, heart, kidney, and liver diseases, as well as diabetes and anemia. White spots and vertical ridges are harmless. Nail problems that sometimes require treatment include: Bacterial and fungal infections Ingrown nails Tumors Warts Keeping your nails clean, dry, and trimmed can help you avoid some problems. Do not remove the cuticle, which can cause infection.

MalaCards based summary: Nail Disease, also known as nail diseases, is related to spondyloarthropathy 1 and psoriasis 11, and has symptoms including pruritus, exanthema and clubbing of nail. An important gene associated with Nail Disease is FZD6 (Frizzled Class Receptor 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Tazarotene and Polihexanide have been mentioned in the context of this disorder. Affiliated tissues include nail, skin and lung, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

Disease Ontology: ¹¹ An integumentary system disease that is located in nail.

Wikipedia: ⁷⁵ A nail disease or onychosis is a disease or deformity of the nail. Although the nail is a structure... more...

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Related Diseases for Nail Disease

Diseases in the Nail Disease family:

Nail Disorder, Nonsyndromic Congenital, 6	Nail Disorder, Nonsyndromic Congenital, 2
Nail Disorder, Nonsyndromic Congenital, 3	Nail Disorder, Nonsyndromic Congenital, 1
Nail Disorder, Nonsyndromic Congenital, 5	Nail Disorder, Nonsyndromic Congenital, 4
Nail Disorder, Nonsyndromic Congenital, 7	Nail Disorder, Nonsyndromic Congenital, 8
Nail Disorder, Nonsyndromic Congenital, 9	Nonsyndromic Congenital Nail Disorder

Diseases related to Nail Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 175)

#	Related Disease	Score	Top Affiliating Genes
1	spondyloarthropathy 1	31.0	IL17F IL17A CCR6
2	psoriasis 11	30.9	IL17RA IL17F IL17A
3	nail disorder, nonsyndromic congenital, 1	30.8	FZD6 CCR6
4	psoriasis	30.5	STAT3 IL22 IL17RA IL17F IL17A CCR6
5	skin disease	29.9	STAT3 STAT1 IL22 IL17RA IL17F IL17A
6	immune deficiency disease	29.8	STAT1 IL17A IL12RB1 CCR6 AIRE
7	dermatophytosis	29.6	IL17F IL17A IL12RB1 CLEC7A CLEC6A CLEC4E
8	candidiasis	29.5	STAT3 STAT1 IL22 IL17RC IL17RA IL17F
9	chronic mucocutaneous candidiasis	28.7	ZNF341 STAT3 STAT1 IL22 IL17RC IL17RA
10	isolated nail anomaly	11.2
11	genetic nail anomaly	11.1
12	syndromic nail anomaly	11.1
13	nail disorder, nonsyndromic congenital, 3	11.0
14	yellow nail syndrome	11.0
15	nail disorder, nonsyndromic congenital, 7	11.0
16	nail dysplasia, isolated congenital	11.0
17	leukonychia totalis-acanthosis-nigricans-like lesions-abnormal hair syndrome	11.0
18	paronychia	11.0
19	tinea unguium	11.0
20	nonsyndromic congenital nail disorder	10.9
21	aspergillosis	10.4	STAT3 CLEC7A CCR6
22	trichosporonosis	10.4	CLEC7A CARD9
23	pustulosis of palm and sole	10.4	IL17F IL17A CCR6
24	autoimmune gastritis	10.4	IL17A CCR6 AIRE
25	inflammatory bowel disease 23	10.4	IL22 CCR6
26	ankylosing spondylitis 1	10.4	IL17RA IL17F IL17A
27	penicilliosis	10.4	IL12RB1 CLEC7A CARD9
28	tinea imbricata	10.4	CLEC7A CLEC6A CARD9
29	mucormycosis	10.4	CLEC7A CCR6 CARD9
30	exanthem	10.4	IL17A EGFR CCR6
31	autoimmune uveitis	10.4	IL17F IL17A CCR6
32	immunodeficiency 29	10.4	IL17RC IL12RB1 CARD9
33	candidal paronychia	10.4	IL17RC CLEC4E
34	psoriatic arthritis	10.4
35	acute generalized exanthematous pustulosis	10.4	IL22 IL17F IL17A
36	immunodeficiency 41 with lymphoproliferation and autoimmunity	10.4	STAT1 DOCK8 CCR6
37	extrapulmonary tuberculosis	10.4	IL17A IL12RB1 CCR6
38	sporotrichosis	10.4	CLEC7A CLEC6A CARD9
39	commensal bacterial infectious disease	10.3	SETBP1 IL17A CCR6
40	inflammatory bowel disease 1	10.3	IL17A CCR6 CARD9
41	folliculitis	10.3	IL17RA IL17A CCR6
42	coccidiosis	10.3	STAT1 IL17A CCR6
43	human cytomegalovirus infection	10.3	IL17A EGFR CCR6
44	t cell deficiency	10.3	IL17A DOCK8 CCR6
45	tinea cruris	10.3	CLEC6A CARD9
46	vitiligo-associated multiple autoimmune disease susceptibility 1	10.3	IL17A CCR6 AIRE
47	autoimmune disease of endocrine system	10.3	IL17A CCR6 AIRE
48	sebaceous gland disease	10.3	IL17A EGFR CCR6
49	nasopharyngitis	10.3	IL17RA IL17F IL17A CCR6
50	rectal disease	10.3	IL17A EGFR CCR6

Graphical network of the top 20 diseases related to Nail Disease:

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Symptoms & Phenotypes for Nail Disease

UMLS symptoms related to Nail Disease:

pruritus; exanthema; clubbing of nail

GenomeRNAi Phenotypes related to Nail Disease according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Reduced mammosphere formation	GR00396-S	9.23	CCR6 CLEC7A EGFR FZD6 IL17A IL17RC

MGI Mouse Phenotypes related to Nail Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.22	AIRE CARD9 CCR6 CLEC4E CLEC7A EGFR
2	immune system	MP:0005387	10.06	AIRE CARD9 CCR6 CLEC4E CLEC6A CLEC7A
3	no phenotypic analysis	MP:0003012	9.91	AIRE CLEC4E CLEC6A EGFR IL17A IL17RA
4	digestive/alimentary	MP:0005381	9.86	AIRE CLEC7A EGFR IL17A IL17F IL22
5	respiratory system	MP:0005388	9.61	AIRE CLEC7A EGFR IL17A IL17F IL17RA
6	hematopoietic system	MP:0005397	9.55	AIRE CARD9 CCR6 CLEC4E CLEC6A CLEC7A

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Drugs & Therapeutics for Nail Disease

Drugs for Nail Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Tazarotene

Approved, Investigational

Phase 4

118292-40-3

5381

Polihexanide

Approved, Investigational

Phase 4

28757-47-3

20977

Ethanol

Approved

Phase 4

64-17-5

702

Triamcinolone

Approved, Vet_approved

Phase 4

124-94-7

31307

Acetaminophen

Approved

Phase 4

103-90-2

1983

Ibuprofen

Approved

Phase 4

15687-27-1

3672

Cathine

Approved, Experimental, Illicit, Vet_approved, Withdrawn

Phase 4

14838-15-4, 492-39-7

131954576 4786 26934

Guaifenesin

Approved, Investigational, Vet_approved

Phase 4

93-14-1

3516

Hydrocodone

Approved, Illicit, Investigational

Phase 4

125-29-1

5284569

Ethyl chloride

Approved, Experimental, Investigational

Phase 4

75-00-3

6337

Keratolytic Agents

Phase 4

Anti-Infective Agents

Phase 4

Disinfectants

Phase 4

Anti-Infective Agents, Local

Phase 4

Hormones

Phase 4

Hormone Antagonists

Phase 4

Pharmaceutical Solutions

Phase 4

Triamcinolone hexacetonide

Phase 4

Triamcinolone diacetate

Phase 4

Triamcinolone Acetonide

Phase 4

6436

glucocorticoids

Phase 4

Immunosuppressive Agents

Phase 4

Immunologic Factors

Phase 4

Analgesics

Phase 4

Antirheumatic Agents

Phase 4

Antipyretics

Phase 4

Acetaminophen, hydrocodone drug combination

Phase 4

Cyclooxygenase Inhibitors

Phase 4

Anti-Inflammatory Agents, Non-Steroidal

Phase 4

Respiratory System Agents

Phase 4

Antitussive Agents

Phase 4

Analgesics, Opioid

Phase 4

Analgesics, Non-Narcotic

Phase 4

Anti-Inflammatory Agents

Phase 4

Narcotics

Phase 4

Chlorpheniramine, phenylpropanolamine drug combination

Phase 4

Anesthetics, Local

Phase 4

Anesthetics

Phase 4

Docetaxel

Approved, Investigational

Phase 3

114977-28-5

148124

Amorolfine

Approved, Investigational

78613-35-1

Itraconazole

Approved, Investigational

84625-61-6

55283

Ciclopirox

Approved, Investigational

29342-05-0

2749

Miconazole

Approved, Investigational, Vet_approved

22916-47-8

4189

Clotrimazole

Approved, Vet_approved

23593-75-1

2812

Terbinafine

Approved, Investigational, Vet_approved

91161-71-6

1549008

Dermatologic Agents

Antifungal Agents

Hydroxyitraconazole

108222

Cytochrome P-450 Enzyme Inhibitors

Cytochrome P-450 CYP3A Inhibitors

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Efficacy of Combined Fractional Carbon Dioxide Laser and Topical Tazarotene in the Treatment of Psoriatic: Nail Disease a Single-blind, Intrapatient Left-to-right Controlled Study.	Unknown status	NCT03263624	Phase 4	Tazarotene Cream 0.1%
2	Efficacy of Intraoperative Surgical Scrubbing in Reducing Bacterial Load After Nail Removal Surgery	Completed	NCT01330706	Phase 4	Polihexanide
3	Use of Platelet-rich Plasma (PRP) Therapy in Patients With Brittle Nail Syndrome	Recruiting	NCT04941807	Phase 4
4	Benefit of Placebo and Different Concentrations of Triamcinolone Acetonide in Nail Psoriasis	Recruiting	NCT03991936	Phase 4	Placebos;Triamcinolone Acetonide 2.5 mg/mL;Triamcinolone Acetonide 5.0 mg/mL;Triamcinolone Acetonide 7.5 mg/mL;Triamcinolone Acetonide 10 mg/mL
5	Analysis of Hydrocodone Compared to Acetaminophen and Ibuprofen for Post-nail Procedure Analgesia	Not yet recruiting	NCT05544734	Phase 4	Hydrocodone 5Mg/Acetaminophen 325Mg Tab;Acetaminophen 1000mg;Ibuprofen 400 mg
6	The Evaluation of External Thermomechanical Stimulation for Pain Reduction in Patients Undergoing Nail Injection	Not yet recruiting	NCT04422795	Phase 4	Ethyl chloride skin refrigerant spray
7	The Evaluation of Topical Hemostatic Powder Containing Hydrophilic Polymer With Potassium Ferrate for Hemostasis Following Nail Surgery	Withdrawn	NCT04384679	Phase 4
8	Randomized Trial Evaluating the Cryotherapy in the Prevention of Nails Toxicity Induced by Taxotere® in Patient Treated for Breast or Prostate Cancer.	Completed	NCT00925418	Phase 3
9	Subclinical Nail Involvement in Relevant Skin Diseases	Unknown status	NCT04092413
10	Pilot Study on the Evaluation of the Efficacy, Tolerability and Safety of Topical and Oral Antifungals in the Treatment of Onychomycosis and Creation of a Library of Dermatological Clinical Isolates	Recruiting	NCT05482763		Terbinafine Topical Gel;Itraconazole 200 mg;Terbinafine 250 mg;Ciclopirox Topical Gel;Amorolfine 50 MG/ML

Search NIH Clinical Center for Nail Disease

Cochrane evidence based reviews: nail diseases

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Genetic Tests for Nail Disease

Genetic tests related to Nail Disease:

#	Genetic test	Affiliating Genes
1	Abnormality of the Nail ²⁸

Sources

Anatomical Context for Nail Disease

Organs/tissues related to Nail Disease:

FMA: Nail

MalaCards : Skin, Lung, Kidney, Liver, Heart, Prostate, Breast

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Publications for Nail Disease

Articles related to Nail Disease:

(show top 50) (show all 526)

#	Title	Authors	PMID	Year
1	Diagnostic Utility of a Revised Formula-based Melanoma Discrimination Index for Nail Streaks in Dermoscopic Practice. ⁴¹	Minagawa A...Sota T	36472366	2022
2	Sustained Resolution of Nail Psoriasis Through 5 Years with Ixekizumab: A Post-Hoc analysis from UNCOVER-3. ⁴¹	Egeberg A...Schuster C	36121210	2022
3	Clinical Clues to Differentiate between Dermatophyte Onychomycosis (DP-OM) and Dermatophytoma-Like Traumatic Onychodystrophy (DP-TO). ⁴¹	Bunyaratavej S...Leeyaphan C	36119939	2022
4	Optimal diagnosis and management of common nail disorders. ⁶²	Lee DK...Lipner SR	35238267	2022
5	A Comprehensive Review of Platelet-Rich Plasma in the Treatment of Dermatologic Disorders. ⁶²	Pixley JN...McMichael AJ	36318219	2022
6	Systematic review of the prevalence of onychomycosis in children. ⁶²	Vestergaard-Jensen S...Saunte DML	36130720	2022
7	An overview of psoriatic arthritis including clinical manifestations, assessment, diagnostic criteria, investigations, drug management and GRAPPA guidelines. ⁶²	Packham J...Tarar B	36356108	2022
8	Management of Nail Disease in Patients With Psoriatic Arthritis: An Updated Literature Review Informing the 2021 GRAPPA Treatment Recommendations. ⁶²	Laheru D...Yazbek MA	36319021	2022
9	Prevalence, genetic diversity and antifungal susceptibility profiles of F. fujikuroi, F. solani and Fusarium incarnatum-equiseti species complexes from onychomycosis in north of Iran. ⁶²	Haghani I...Hedayati MT	35775829	2022
10	Bacterial nanocellulose patches as a carrier for hydrating formulations to improve the topical treatment of nail diseases. ⁶²	Bellmann T...Fischer D	36209980	2022
11	Investigating the efficacy and safety of calcipotriol/betamethasone dipropionate foam and laser microporation for psoriatic nail disease-A hybrid trial using a smartphone application, optical coherence tomography, and patient-reported outcome measures. ⁶²	Ortner VK...Haedersdal M	36321647	2022
12	Radiological Imaging of Nail Disorders (PART II) - Radiological Features of Nail Disease. ⁶²	Grover C...Jakhar D	36386741	2022
13	Sox9 Is Required for Nail-Bed Differentiation and Digit-Tip Regeneration. ⁶²	Lao M...Barrionuevo FJ	35398376	2022
14	Novel and Investigational Treatments for Onychomycosis. ⁶²	Gregoriou S...Rigopoulos D	36294644	2022
15	Consensus statements for pharmacological management, monitoring of therapies, and comorbidity management of psoriatic arthritis in the United Arab Emirates. ⁶²	Alnaqbi KA...Al-Saleh J	35916205	2022
16	Secukinumab demonstrates high and sustained efficacy in nail psoriasis: post hoc analysis from phase III trials in patients with psoriatic arthritis. ⁶²	Reich K...Gottlieb AB	35257363	2022
17	Real-world effectiveness and safety of tildrakizumab in long-term treatment of plaque psoriasis: Results from the non-interventional, prospective, multicentre study TILOT. ⁶²	Tsianakas A...Korge B	36066998	2022
18	Poor Antifungal Coverage for Onychomycosis in a Cross-Sectional Analysis of Medicaid Formularies. ⁶²	Falotico JM...Lipner SR	36251605	2022
19	Nail lichen planus: A review of clinical presentation, diagnosis and therapy. ⁶²	Grover C...Baran R	35272870	2022
20	Friction-Induced Skin Disorders-A Review. ⁶²	Hsieh CY...Tsai TF	35951433	2022
21	Epidemiology of Onychomycosis in Chinese Mainland: A 30-year Retrospective Study. ⁶²	Song G...Liang G	35819711	2022
22	Review of the literature on the efficacy and safety of a new cosmetic topical treatment containing Pistacia lentiscus and hyaluronic acid for the treatment of nail plate damages. ⁶²	Starace M...Piraccini BM	35962760	2022
23	Severe Psoriasis Presenting in 3-Year-Old Child With Nail Dystrophy: Response to Biologic Treatment. ⁶²	Rinck D...Siegfried E	35946980	2022
24	Relevant insights into onychomycosis' pathogenesis related to the effectiveness topical treatment. ⁶²	Costa PS...Svidzinski TIE	35716926	2022
25	Nail involvement in autosomal recessive congenital ichthyosis. ⁶²	Zaouak A...Hammami H	35181410	2022
26	[Association of skin lesion severity with clinical features of psoriatic arthritis]. ⁶²	Liu HL...Zeng XF	35764561	2022
27	Impact of clinical domains other than arthritis on composite outcomes in psoriatic arthritis: comparison of treatment effects in the SEAM-PsA trial. ⁶²	Helliwell PS...Gladman DD	35863864	2022
28	Unequal relevance between different subtypes of fingernail psoriasis and psoriatic arthritis. ⁶²	Cui R...Dai SM	35182271	2022
29	Radiological Imaging in Nail Unit Disorders (Part I) - Modalities Used. ⁶²	Grover C...Jakhar D	36262575	2022
30	Treatment of nail diseases in the emergency department. ⁶²	Fritz M...Fleischer AB	34289796	2022
31	Secukinumab provides sustained improvement in nail psoriasis, signs and symptoms of psoriatic arthritis and low rate of radiographic progression in patients with concomitant nail involvement: 2-year results from the Phase III FUTURE 5 study. ⁶²	Nash P...Gaillez C	34494957	2022
32	The epidemiology and etiology of onychomycosis in 2 laboratory centers affiliated to Tehran university of medical sciences during 2019-2020. ⁶²	Razavyoon T...Ghasemi Z	35765553	2022
33	Combination Therapy Should Be Reserved as Second-Line Treatment of Onychomycosis: A Systematic Review of Onychomycosis Clinical Trials. ⁶²	Falotico JM...Lipner SR	35330281	2022
34	Oral antifungal therapies for toenail onychomycosis: a systematic review with network meta-analysis toenail mycosis: network meta-analysis. ⁶²	Favero MLD...Pontarolo R	32043906	2022
35	Being overweight is associated with not reaching low disease activity in women but not men with psoriatic arthritis. ⁶²	Mulder MLM...Vriezekolk JE	33831180	2022
36	Witch Nails (Krt90whnl): A spontaneous mouse mutation affecting nail growth and development. ⁶²	Sundberg JP...Rice RH	36374931	2022
37	Bart's syndrome associated with a disorder of sexual differentiation: An atypical presentation in a Cameroonian newborn. ⁶²	Sigha OB...Kouotou EA	35028143	2022
38	Clinical, dermoscopic, and histopathological evaluations of patients with nail disorders. ⁶²	Abu El-Hamd M...El-Sharkawy REED	34806290	2022
39	Characterisation of the nail microbiome in psoriatic and nonpsoriatic patients with onychomycosis. ⁶²	Wang S...Li R	34549836	2022
40	Updated Perspectives on the Diagnosis and Management of Onychomycosis. ⁶²	Falotico JM...Lipner SR	36133401	2022
41	Challenge of Nail Psoriasis: An Update Review. ⁶²	Ji C...Cheng B	34478047	2021
42	Psoriatic onycho-pachydermo periostitis (POPP): a case report treated successfully with IL-17 blockade and a literature review on characteristics, pathogenesis, and treatment. ⁶²	Sakellariou GT...Vounotrypidis P	33830360	2021
43	A questionnaire survey study on nail disease prevalence in patients under podologic foot care. ⁶²	Biedermann A...Deutscher Verband fur Podologie (ZFD) e.V.	34743587	2021
44	Investigation of the Dual-Stage Method of Active Er:YLF Laser Drug Delivery Through the Nail and Laser-Induced Transformations of the Drug Extinction Spectrum. ⁶²	Belikov AV...Smirnov SN	33450786	2021
45	The Penetrance of Topical Nail Therapy: Limitations and Current Enhancements. ⁶²	Phan K...Vlahovic TC	34538431	2021
46	Three-dimensional structure analysis of mouse nails using synchrotron radiation. ⁶²	Yoo H...Lee O	34002795	2021
47	Apremilast improves quality of life and ultrasonography parameters in patients with nail psoriasis: A prospective cohort study. ⁶²	Munoz-Santos C...Guilabert A	34390034	2021
48	Therapeutic Recommendations for the Treatment of Toenail Onychomycosis in the US. ⁶²	Lipner SR...Elewski B	34636509	2021
49	Nutrition and nail disease. ⁶²	Muddasani S...Sloan SB	34785009	2021
50	Nail Peeling with Glycolic Acid 50%: A Prospective Study of 20 Cases. ⁶²	Chiheb S...Hali F	34604324	2021

Sources

Genes for Nail Disease

Genes related to Nail Disease (2 elite genes):

(show all 39)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	FZD6	Frizzled Class Receptor 6	Protein Coding	405.09	Pathogenic ⁵ DISEASES inferred ¹⁴
2	POGZ	Pogo Transposable Element Derived With ZNF Domain	Protein Coding	400	Pathogenic ⁵
3	SETBP1	SET Binding Protein 1	Protein Coding	25	Likely pathogenic ⁵
4	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	11.48	DISEASES inferred ¹⁴ ¹⁴
5	AIRE	Autoimmune Regulator	Protein Coding	8.62	DISEASES inferred ¹⁴
6	CARD9	Caspase Recruitment Domain Family Member 9	Protein Coding	7.95	DISEASES inferred ¹⁴
7	IL17F	Interleukin 17F	Protein Coding	7.86	DISEASES inferred ¹⁴
8	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	7.78	DISEASES inferred ¹⁴
9	IL17RA	Interleukin 17 Receptor A	Protein Coding	7.77	DISEASES inferred ¹⁴
10	IL17A	Interleukin 17A	Protein Coding	7.68	DISEASES inferred ¹⁴
11	CLEC7A	C-Type Lectin Domain Containing 7A	Protein Coding	7.34	DISEASES inferred ¹⁴
12	IL17RC	Interleukin 17 Receptor C	Protein Coding	7.18	DISEASES inferred ¹⁴
13	IL12RB1	Interleukin 12 Receptor Subunit Beta 1	Protein Coding	7.13	DISEASES inferred ¹⁴
14	CLEC6A	C-Type Lectin Domain Containing 6A	Protein Coding	6.94	DISEASES inferred ¹⁴
15	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	6.83	DISEASES inferred ¹⁴
16	DOCK8	Dedicator Of Cytokinesis 8	Protein Coding	6.7	DISEASES inferred ¹⁴
17	EGFR	Epidermal Growth Factor Receptor	Protein Coding	6.67	DISEASES inferred ¹⁴
18	IL22	Interleukin 22	Protein Coding	6.59	DISEASES inferred ¹⁴
19	CLEC4E	C-Type Lectin Domain Family 4 Member E	Protein Coding	6.52	DISEASES inferred ¹⁴
20	ZNF341	Zinc Finger Protein 341	Protein Coding	6.41	DISEASES inferred ¹⁴
21	CD4	CD4 Molecule	Protein Coding	6.35	DISEASES inferred ¹⁴
22	TRAF3IP2	TRAF3 Interacting Protein 2	Protein Coding	6.28	DISEASES inferred ¹⁴
23	RSPO4	R-Spondin 4	Protein Coding	6.22	DISEASES inferred ¹⁴
24	IFNA1	Interferon Alpha 1	Protein Coding	6.17	DISEASES inferred ¹⁴
25	TYK2	Tyrosine Kinase 2	Protein Coding	6.14	DISEASES inferred ¹⁴
26	RORC	RAR Related Orphan Receptor C	Protein Coding	6.09	DISEASES inferred ¹⁴
27	IL6	Interleukin 6	Protein Coding	6.03	DISEASES inferred ¹⁴
28	IL23A	Interleukin 23 Subunit Alpha	Protein Coding	6	DISEASES inferred ¹⁴
29	IL23R	Interleukin 23 Receptor	Protein Coding	5.98	DISEASES inferred ¹⁴
30	TNF	Tumor Necrosis Factor	Protein Coding	5.96	DISEASES inferred ¹⁴
31	NLRP5	NLR Family Pyrin Domain Containing 5	Protein Coding	5.84	DISEASES inferred ¹⁴
32	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	5.83	DISEASES inferred ¹⁴ ¹⁴
33	CD8A	CD8a Molecule	Protein Coding	5.83	DISEASES inferred ¹⁴
34	IL25	Interleukin 25	Protein Coding	5.83	DISEASES inferred ¹⁴
35	NUDT10	Nudix Hydrolase 10	Protein Coding	5.81	DISEASES inferred ¹⁴
36	CCRL2	C-C Motif Chemokine Receptor Like 2	Protein Coding	5.73	DISEASES inferred ¹⁴
37	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	5.7	DISEASES inferred ¹⁴
38	KCNRG	Potassium Channel Regulator	Protein Coding	5.7	DISEASES inferred ¹⁴
39	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	5.69	DISEASES inferred ¹⁴

Sources

Variations for Nail Disease

ClinVar genetic disease variations for Nail Disease:

⁵

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	FZD6	NM_003506.4(FZD6):c.1531C>T (p.Arg511Cys)	SNV	Pathogenic	30356	rs151339003	GRCh37: 8:104340634-104340634 GRCh38: 8:103328406-103328406
2	FZD6	NM_003506.4(FZD6):c.1750G>T (p.Glu584Ter)	SNV	Pathogenic	30355	rs151339002	GRCh37: 8:104342091-104342091 GRCh38: 8:103329863-103329863
3	POGZ	NM_015100.4(POGZ):c.2771del (p.Pro924fs)	DEL	Pathogenic	523510	rs1553212868	GRCh37: 1:151378740-151378740 GRCh38: 1:151406264-151406264
4	SETBP1	NM_015559.3(SETBP1):c.2614G>A (p.Gly872Arg)	SNV	Likely Pathogenic	523513	rs1555706928	GRCh37: 18:42531919-42531919 GRCh38: 18:44951954-44951954
5	PKD1	NM_001009944.3(PKD1):c.226C>T (p.His76Tyr)	SNV	Uncertain Significance	523385	rs932577597	GRCh37: 16:2169369-2169369 GRCh38: 16:2119368-2119368
6	OFD1	NM_003611.3(OFD1):c.1999G>A (p.Ala667Thr)	SNV	Uncertain Significance	523463	rs1394450537	GRCh37: X:13778578-13778578 GRCh38: X:13760459-13760459

Sources

Expression for Nail Disease

Search GEO for disease gene expression data for Nail Disease.

Sources

Pathways for Nail Disease

Pathways related to Nail Disease according to GeneCards Suite gene sharing:

(show all 27)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.77	CARD9 CCR6 CLEC4E CLEC6A CLEC7A IL12RB1
2	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.74	STAT3 STAT1 IL22 IL17RC IL17RA IL17A
3	MIF Mediated Glucocorticoid Regulation ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ Overview of proinflammatory and profibrotic mediators ⁷⁴ PEDF Induced Signaling ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.54	STAT3 IL22 IL17RC IL17RA IL17F IL17A
4	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.28	STAT3 STAT1 IL22 IL17RC IL17RA IL17A
5	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.22	IL22 IL17RC IL17RA IL17A IL12RB1 EGFR
6	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.21	IL12RB1 IL17A IL17F IL17RA IL17RC IL22
7	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.53	STAT3 STAT1 IL17A IL12RB1 EGFR
8	IL-1 Family Signaling Pathways ⁶⁵ Show member pathways IL1 signaling pathway ⁶⁷ Immune response IL-1 signaling pathway ²² Interleukin-1 (IL-1) structural pathway ⁷⁴ Interleukin-33 signaling ⁶⁶ Interleukin-36 pathway ⁶⁶ Mucin expression in CF via TLRs, EGFR signaling pathways ²² Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	12.49	STAT1 EGFR CLEC7A CLEC6A CLEC4E CARD9
9	NF-kappaB Signaling ³	12.45	STAT3 STAT1 IL17A CARD9
10	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.44	STAT3 STAT1 IL17F IL17A IL12RB1 EGFR
11	CLEC7A (Dectin-1) signaling ⁶⁶ Show member pathways Alternative NF-kappaB pathway ⁶¹ CLEC7A/inflammasome pathway ⁶⁶ C-type lectin receptors (CLRs) ⁶⁶	12.32	CLEC7A CLEC6A CLEC4E CARD9
12	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ⁶⁷ IL-17 signaling pathway ⁷⁴ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.18	STAT3 IL17RC IL17RA IL17F IL17A
13	Colorectal Cancer Metastasis ⁶⁴	12.12	STAT3 STAT1 FZD6 EGFR
14	Immune response Antigen presentation by MHC class II ²² Show member pathways G-protein signaling N-RAS regulation pathway ²² IL-22 Pathway ⁶⁴ Immune response IL-22 signaling pathway ²²	12.09	STAT3 STAT1 IL22 IL12RB1
15	MAP kinase activation ⁶⁶ Show member pathways Interleukin-17 signaling ⁶⁶ MAP3K8 (TPL2)-dependent MAPK1/3 activation ⁶⁶	12.07	IL17A IL17F IL17RA IL17RC
16	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.88	STAT3 STAT1 IL17F IL17A
17	IL12-mediated signaling events ⁶¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²²	11.85	STAT3 STAT1 IL12RB1
18	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	11.77	STAT3 STAT1 IL17F IL17A IL12RB1
19	Allograft rejection ⁷⁴	11.76	STAT1 IL22 IL17A
20	Innate Lymphoid Cells Differentiation ⁶⁵	11.71	IL22 IL17A IL12RB1 CCR6
21	Th17 cell differentiation pathway ⁷⁴	11.49	STAT3 STAT1 IL22 IL17F IL17A
22	Signaling events mediated by TCPTP ⁶¹ Show member pathways MET activates PI3K/AKT signaling ⁶⁶	11.42	STAT3 STAT1 EGFR
23	Cytokine production by Th17 cells in CF (Mouse model) ²² Show member pathways Cytokine production by Th17 cells in CF ²²	11.4	STAT3 IL17RC IL17RA IL17F IL17A IL12RB1
24	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11.32	STAT3 STAT1 IL22 IL17F IL12RB1
25	Th17 Differentiation ⁶⁵ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.13	STAT3 STAT1 IL22 IL17RA IL17F IL17A
26	Interleukin-20 family signaling ⁶⁶	11.11	STAT3 STAT1 IL22
27	Endothelial cell senescence ⁷⁴	10.2	IL17RC IL17RA IL17A

Sources

GO Terms for Nail Disease

Biological processes related to Nail Disease according to GeneCards Suite gene sharing:

(show all 22)

#	Name	GO ID	Score	Top Affiliating Genes
1	innate immune response	GO:0045087	10.33	CARD9 CLEC4E CLEC6A CLEC7A IL17A IL17F
2	inflammatory response	GO:0006954	10.3	CLEC7A IL17A IL17F IL17RA IL17RC IL22
3	cytokine-mediated signaling pathway	GO:0019221	10.2	STAT3 STAT1 IL17RC IL12RB1
4	positive regulation of tumor necrosis factor production	GO:0032760	10.16	STAT3 IL17A CLEC7A CARD9
5	positive regulation of cytokine production	GO:0001819	10.1	IL17F CLEC6A CLEC4E CARD9
6	immune system process	GO:0002376	10.02	IL17RA IL17F IL17A CLEC7A CLEC6A CLEC4E
7	defense response to fungus	GO:0050832	10.01	IL17RC IL17RA IL17A CLEC6A
8	interleukin-17-mediated signaling pathway	GO:0097400	9.91	IL17RA IL17F IL17A
9	response to yeast	GO:0001878	9.89	CLEC7A CLEC6A
10	T-helper 17 type immune response	GO:0072538	9.88	STAT3 IL17RA
11	granulocyte chemotaxis	GO:0071621	9.88	IL17RC IL17RA
12	fibroblast activation	GO:0072537	9.87	IL17RA IL17A
13	antifungal innate immune response	GO:0061760	9.86	CARD9 CLEC4E CLEC6A CLEC7A
14	positive regulation of interleukin-23 production	GO:0032747	9.85	IL17RA IL17A CLEC7A
15	regulation of interleukin-2 production	GO:0032663	9.84	IL17F CARD9
16	positive regulation of antimicrobial peptide production	GO:0002225	9.83	IL17F IL17A
17	detection of yeast	GO:0001879	9.81	CLEC7A CLEC6A
18	positive regulation of chemokine (C-X-C motif) ligand 1 production	GO:2000340	9.8	IL17RA IL17F IL17A
19	positive regulation of interleukin-6 production	GO:0032755	9.8	STAT3 IL17RC IL17RA IL17F IL17A CLEC7A
20	positive regulation of T-helper 17 type immune response	GO:2000318	9.76	IL12RB1 CLEC7A CLEC6A CARD9
21	biological process involved in interspecies interaction between organisms	GO:0044419	9.61	CLEC6A CLEC4E
22	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.47	STAT3 IL17RC IL17RA IL17F IL17A CLEC7A