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MIFTS: 54

Nail Disease

Categories: Bone diseases, Fetal diseases, Genetic diseases, Rare diseases, Skin diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Nail Disease

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MalaCards integrated aliases for Nail Disease:

Name: Nail Disease 12 6 15
Nail Diseases 42 43 71
Abnormality of the Nail 29 6
Nail Anomaly 58

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases Fetal diseases
Anatomical: Skin diseases Bone diseases
See all MalaCards categories (disease lists)
ICD10: 32
Orphanet: 58  
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:4123
ICD9CM 34 703
MeSH 43 D009260
SNOMED-CT 67 17790008
UMLS via Orphanet 72 C0265997 C0853087
Orphanet 58 ORPHA79368
UMLS 71 C0027339
Sources

Summaries for Nail Disease

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MedlinePlus : 42 Your toenails and fingernails protect the tissues of your toes and fingers. They are made up of layers of a hardened protein called keratin, which is also in your hair and skin. The health of your nails can be a clue to your overall health. Healthy nails are usually smooth and consistent in color. Specific types of nail discoloration and changes in growth rate can be signs of lung, heart, kidney, and liver diseases, as well as diabetes and anemia. White spots and vertical ridges are harmless. Nail problems that sometimes require treatment include Bacterial and fungal infections Ingrown nails Tumors Warts Keeping your nails clean, dry, and trimmed can help you avoid some problems. Do not remove the cuticle, which can cause infection.

MalaCards based summary : Nail Disease, also known as nail diseases, is related to psoriatic arthritis and psoriasis, and has symptoms including pruritus, exanthema and clubbing of nail. An important gene associated with Nail Disease is FZD6 (Frizzled Class Receptor 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Tazarotene and Ciclopirox have been mentioned in the context of this disorder. Affiliated tissues include nail, skin and lung, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Disease Ontology : 12 An integumentary system disease that is located in nail.

Wikipedia : 74 A nail disease or onychosis is a disease or deformity of the nail. Although the nail is a structure... more...

Sources

Related Diseases for Nail Disease

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Diseases in the Nail Disease family:

Nail Disorder, Nonsyndromic Congenital, 6 Nail Disorder, Nonsyndromic Congenital, 2
Nail Disorder, Nonsyndromic Congenital, 3 Nail Disorder, Nonsyndromic Congenital, 1
Nail Disorder, Nonsyndromic Congenital, 5 Nail Disorder, Nonsyndromic Congenital, 4
Nail Disorder, Nonsyndromic Congenital, 7 Nail Disorder, Nonsyndromic Congenital, 8
Nail Disorder, Nonsyndromic Congenital, 9 Nonsyndromic Congenital Nail Disorder

Diseases related to Nail Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 217)
# Related Disease Score Top Affiliating Genes
1 psoriatic arthritis 31.0 IL22 IL17RA IL17A CCR6
2 psoriasis 30.5 STAT3 IL22 IL17RA IL17F IL17A CD4
3 hair disease 30.1 EGFR CD4 CCR6 AIRE
4 immune deficiency disease 29.9 STAT1 IL12RB1 CD4 CCR6 AIRE
5 dermatophytosis 29.5 IL17A IL12RB1 CLEC7A CLEC6A CLEC4E CD4
6 candidiasis 29.1 STAT3 STAT1 IL22 IL17RC IL17RA IL17F
7 chronic mucocutaneous candidiasis 28.1 STAT3 STAT1 IL22 IL17RC IL17RA IL17F
8 isolated nail anomaly 12.3
9 genetic nail anomaly 12.2
10 syndromic nail anomaly 12.2
11 paronychia 11.2
12 cutaneous telangiectasia and cancer syndrome, familial 11.2
13 short stature, onychodysplasia, facial dysmorphism, and hypotrichosis 11.2
14 palmoplantar keratoderma and congenital alopecia 1 11.0
15 tooth agenesis, selective, 4 10.9
16 nail-patella syndrome 10.9
17 keratosis palmoplantaris striata ii 10.9
18 nonsyndromic congenital nail disorder 10.9
19 tinea unguium 10.9
20 nail disorder, nonsyndromic congenital, 1 10.6 FZD6 CCR6 AIRE
21 systemic autoimmune disease 10.6 IL17A AIRE
22 candidal paronychia 10.6 IL17RC CLEC4E
23 wissler-fanconi syndrome 10.6 CD4 AIRE
24 tinea pedis 10.6 CLEC7A CLEC6A CARD9
25 geotrichosis 10.6 STAT1 CD4
26 acute generalized exanthematous pustulosis 10.6 IL22 IL17F IL17A
27 neonatal candidiasis 10.5 CLEC7A CLEC6A
28 syphilis 10.5 IL17A CD4 CCR6
29 tinea corporis 10.5 CLEC6A CLEC4E CARD9
30 pneumonic tularemia 10.5 IL17A CD4 CCR6
31 tularemia 10.5 IL17A CD4 CCR6
32 scleral disease 10.5 IL17A CD4 CCR6
33 penicilliosis 10.5 CLEC7A CD4 CARD9
34 meningovascular neurosyphilis 10.5 IL17RA IL17A CD4
35 fungal keratitis 10.5 CLEC7A CLEC4E
36 autoimmune enteropathy 10.5 STAT3 IL17A
37 dacryoadenitis 10.5 IL17A CD4 CCR6
38 allergic contact dermatitis 10.5 IL17F IL17A CD4
39 iritis 10.5 IL17A CD4 CCR6
40 fungal meningitis 10.5 IL17A CD4 CCR6
41 central nervous system vasculitis 10.5 IL17A CD4 CCR6
42 autoimmune glomerulonephritis 10.5 IL17A CD4 CCR6
43 autoimmune disease of urogenital tract 10.5 IL17A CD4 CCR6
44 viral pneumonia 10.5 IL17A CD4 CCR6
45 blepharitis 10.5 STAT1 CD4 CCR6
46 intestinal schistosomiasis 10.5 IL17A CD4 CCR6
47 sporotrichosis 10.5 CLEC7A CD4 CARD9
48 thrombocytopenia due to platelet alloimmunization 10.5 IL17A CD4 CCR6
49 lichen disease 10.5 IL17A CD4 CCR6
50 autoimmune disease of peripheral nervous system 10.5 IL17A CD4 CCR6

Graphical network of the top 20 diseases related to Nail Disease:



Diseases related to Nail Disease
Sources

Symptoms & Phenotypes for Nail Disease

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UMLS symptoms related to Nail Disease:


pruritus, exanthema, clubbing of nail

GenomeRNAi Phenotypes related to Nail Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.23 CCR6 CLEC7A EGFR FZD6 IL17A IL17RC

MGI Mouse Phenotypes related to Nail Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.36 AIRE CARD9 CCR6 CD4 CLEC4E CLEC6A
2 immune system MP:0005387 10.3 AIRE CARD9 CCR6 CD4 CLEC4E CLEC6A
3 homeostasis/metabolism MP:0005376 10.25 AIRE CARD9 CCR6 CD4 CLEC4E CLEC7A
4 digestive/alimentary MP:0005381 10.11 AIRE CD4 CLEC7A EGFR IL17A IL17F
5 mortality/aging MP:0010768 10.07 AIRE CD4 CLEC4E CLEC6A CLEC7A EGFR
6 integument MP:0010771 9.97 CD4 EGFR FZD6 IL12RB1 IL17A IL17RA
7 no phenotypic analysis MP:0003012 9.76 AIRE CD4 CLEC4E CLEC6A EGFR IL17A
8 normal MP:0002873 9.61 AIRE CCR6 CD4 EGFR FZD6 IL17F
9 respiratory system MP:0005388 9.28 AIRE CLEC7A EGFR IL17A IL17F IL17RA
Sources

Drugs & Therapeutics for Nail Disease

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Drugs for Nail Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tazarotene Approved, Investigational Phase 4 118292-40-3 5381
2
Ciclopirox Approved, Investigational Phase 4 29342-05-0 2749
3
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
4
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
5
Amorolfine Approved, Investigational Phase 4 78613-35-1
6
Polihexanide Approved, Investigational Phase 4 28757-47-3
7
Acitretin Approved Phase 4 55079-83-9, 69427-46-9 6437841
8
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
9
Apremilast Approved, Investigational Phase 4 608141-41-9 11561674
10 Cytochrome P-450 Enzyme Inhibitors Phase 4
11 Antifungal Agents Phase 4
12 Cytochrome P-450 CYP3A Inhibitors Phase 4
13 Dermatologic Agents Phase 4
14 Keratolytic Agents Phase 4
15 Disinfectants Phase 4
16 Anti-Infective Agents, Local Phase 4
17 Anti-Infective Agents Phase 4
18 Immunologic Factors Phase 4
19 Hormones Phase 4
20 Hormone Antagonists Phase 4
21 glucocorticoids Phase 4
22 Pharmaceutical Solutions Phase 4
23 triamcinolone acetonide Phase 4
24 Triamcinolone diacetate Phase 4
25 Immunosuppressive Agents Phase 4
26 Triamcinolone hexacetonide Phase 4
27 Anti-Inflammatory Agents Phase 4
28 Analgesics, Non-Narcotic Phase 4
29 Analgesics Phase 4
30 Antirheumatic Agents Phase 4
31 Anti-Inflammatory Agents, Non-Steroidal Phase 4
32 Hemostatics Phase 4
33
Docetaxel Approved, Investigational Phase 3 114977-28-5 148124
34
Calcitriol Approved, Nutraceutical Phase 2, Phase 3 32222-06-3 5280453 134070
35
Indirubin Investigational Phase 2, Phase 3 479-41-4
36 Micronutrients Phase 2, Phase 3
37 Olive Phase 2, Phase 3
38 Trace Elements Phase 2, Phase 3
39 Vitamins Phase 2, Phase 3
40 Vasoconstrictor Agents Phase 2, Phase 3
41 Nutrients Phase 2, Phase 3
42 Ophthalmic Solutions Phase 2, Phase 3
43 Calcipotriene Phase 2, Phase 3
44 Calcium, Dietary Phase 2, Phase 3
45
Calcium Nutraceutical Phase 2, Phase 3 7440-70-2 271

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Efficacy of Combined Fractional Carbon Dioxide Laser and Topical Tazarotene in the Treatment of Psoriatic: Nail Disease a Single-blind, Intrapatient Left-to-right Controlled Study. Unknown status NCT03263624 Phase 4 Tazarotene Cream 0.1%
2 A Multicentre, Randomized, Controlled Study of the Efficacy, Safety and Cost-effectiveness of a Sequential Therapy With RV4104A Ointment, Ciclopiroxolamine Cream and Ciclopirox Film-forming Solution Compared With Amorolfine Nail Lacquer Alone for the Treatment of Dermatophytic Onychomycosis (Toenail) Without Matrix Involvement Unknown status NCT01014637 Phase 4 Amorolfine (Antifungal);RV4104A, Ciclopiroxolamine, Cyclopirox (Keratolytic Agents/Antifungal)
3 Efficacy of Intraoperative Surgical Scrubbing in Reducing Bacterial Load After Nail Removal Surgery Completed NCT01330706 Phase 4 Polihexanide
4 Evaluation of Nail Psoriasis Severity Index (NAPSI) and Modified Napsi in Patients With Nail Psoriasis Treated With Acitretin Completed NCT00723437 Phase 4 acitretin
5 Benefit of Placebo and Different Concentrations of Triamcinolone Acetonide in Nail Psoriasis Recruiting NCT03991936 Phase 4 Placebos;Triamcinolone Acetonide 2.5 mg/mL;Triamcinolone Acetonide 5.0 mg/mL;Triamcinolone Acetonide 7.5 mg/mL;Triamcinolone Acetonide 10 mg/mL
6 An Investigator Initiated Open Label Study Evaluating the Efficacy and Tolerability of Oral Apremilast for the Treatment of Nail Psoriasis Enrolling by invitation NCT03022617 Phase 4 Apremilast
7 The Evaluation of Topical Hemostatic Powder Containing Hydrophilic Polymer With Potassium Ferrate for Hemostasis Following Nail Surgery Not yet recruiting NCT04384679 Phase 4
8 The Evaluation of External Thermomechanical Stimulation for Pain Reduction in Patients Undergoing Nail Injection Not yet recruiting NCT04422795 Phase 4
9 Randomized Trial Evaluating the Cryotherapy in the Prevention of Nails Toxicity Induced by Taxotere® in Patient Treated for Breast or Prostate Cancer. Completed NCT00925418 Phase 3
10 Evaluation of the Efficacy and Safety of Indigo Naturalis Oil Extract and Calcipotriol Solution in Patients With Nail Psoriasis Completed NCT01445886 Phase 2, Phase 3 Indigo Naturalis Extract in Oil;Calcipotriol Solution
11 Randomized Controlled Trial of 308 nm Excimer Laser for Treatment of Nail Psoriasis Completed NCT02168933
12 Subclinical Nail Involvement in Relevant Skin Diseases Not yet recruiting NCT04092413

Search NIH Clinical Center for Nail Disease

Cochrane evidence based reviews: nail diseases

Sources

Genetic Tests for Nail Disease

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Genetic tests related to Nail Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Nail 29
Sources

Anatomical Context for Nail Disease

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The Foundational Model of Anatomy Ontology organs/tissues related to Nail Disease:

19
Nail

MalaCards organs/tissues related to Nail Disease:

40
Skin, Lung, Heart, Kidney, Liver, Breast, Prostate
Sources

Publications for Nail Disease

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Articles related to Nail Disease:

(show top 50) (show all 441)
# Title Authors PMID Year
1
Onychomadesis secondary to hand-foot-and-mouth disease: report of two cases. 42
32165023 2020
2
Melanonychia associated with subungual follicular inclusions: report of three cases. 42
32173139 2020
3
Acremonium nail bed mycetoma masquerading as subungual squamous cell carcinoma. 42
32155029 2020
4
The musculoskeletal impairment negatively impacts the quality of life of children and adolescents with psoriasis. 61
32552795 2020
5
Combination of toenail thinning and photodynamic therapy in distal and lateral subungual onychomycosis treatment: A case report. 61
32109622 2020
6
Pemphigus vegetans with paronychia-like changes resistant to rituximab therapy. 61
32367637 2020
7
Mixed Infection of Toe Nail Caused by Trichosporon asahii and Rhodotorula mucilaginosa. 61
31760556 2020
8
Trachyonychia: a retrospective study of 122 patients in a period of 30 years. 61
31923322 2020
9
Prevalence of extra-articular manifestations in psoriatic arthritis: a systematic review and meta-analysis. 61
32160297 2020
10
Clinical improvement in psoriatic nail disease and psoriatic arthritis with tildrakizumab treatment. 61
31899569 2020
11
Oral antifungal therapies for toenail onychomycosis: a systematic review with network meta-analysis toenail mycosis: network meta-analysis. 61
32043906 2020
12
Impact of Having Family History of Psoriasis or Psoriatic Arthritis on Psoriatic Disease. 61
30680951 2020
13
An Open Study to Evaluate Effectiveness and Tolerability of a Nail Oil Composed of Vitamin E and Essential Oils in Mild to Moderate Distal Subungual Onychomycosis. 61
32021856 2020
14
Formulations Based on Natural Ingredients for the Treatment of Nail Diseases. 61
31969086 2020
15
Optical coherence tomography of onychomycosis: proposed terminology and a suggestion of practical usage. 61
31595307 2020
16
Clinical Observation and Follow-Up of Subungual Splinter Hemorrhages of Toenails in Chinese Adults. 61
32029933 2020
17
Fractional carbon dioxide laser and topical tioconazole in the treatment of fingernail onychomycosis. 61
31025207 2019
18
Onychoscopy with red light for vascular pattern identification: a study of 33 patients. 61
31287600 2019
19
Emerging drugs for the treatment of onychomycosis. 61
31652088 2019
20
Adalimumab for nail psoriasis: efficacy and safety over 52 weeks from a phase-3, randomized, placebo-controlled trial. 61
31304993 2019
21
A Double Case of Nail-Patella Syndrome in the Same Family: The Importance of Nail Changes as Diagnostic Clues for Renal Involvement. 61
31799274 2019
22
The ambulatory care burden of nail conditions in the United States. 61
31613182 2019
23
Paclitaxel-related nail toxicity. 61
31542098 2019
24
The use of ultrasonography in the diagnosis of nail disease among patients with psoriasis and psoriatic arthritis: a systematic review. 61
31488208 2019
25
Should Methotrexate Have Any Place in the Treatment of Psoriatic Arthritis? 61
31277747 2019
26
Disease burden and treatment challenges of psoriatic arthritis in Africa and the Middle East. 61
31134289 2019
27
Recommendations for the definition, evaluation, and treatment of nail psoriasis in adult patients with no or mild skin psoriasis: A dermatologist and nail expert group consensus. 61
30731172 2019
28
Active Er-laser drug delivery using drug-impregnated gel for treatment of nail diseases. 61
31467776 2019
29
Fabrication of Dissolvable Microneedle Patches Using an Innovative Laser-Cut Mould Design to Shortlist Potentially Transungual Delivery Systems: In Vitro Evaluation. 61
31172376 2019
30
Onychoscopic evaluation of distal and lateral subungual onychomycosis: A cross-sectional study in Lebanon. 61
31321338 2019
31
Factors associated with onychomycosis in nail psoriasis: a multicenter study in Pakistan. 61
30615189 2019
32
Three-dimensional nail imaging by optical coherence tomography: a novel biomarker of response to therapy for nail disease in psoriasis and psoriatic arthritis. 61
30246363 2019
33
Psoriatic arthritis for dermatologists. 61
31014154 2019
34
Analysis of nail-related content in the basic dermatology curriculum. 61
31116810 2019
35
What's New in Nail Disorders. 61
30850036 2019
36
Subclinical Onychomycosis: Not Present in HIV-Positive Population? 61
31049337 2019
37
Molecular identification and antifungal susceptibility of clinical fungal isolates from onychomycosis (uncommon and emerging species). 61
30255665 2019
38
A survey among dermatologists: diagnostics of superficial fungal infections - what is used and what is needed to initiate therapy and assess efficacy? 61
30468532 2019
39
Evaluation of Risk Factors Associated with Diabetic Foot Ulcers in Saudi Arabia. 61
30117397 2019
40
Novel Drug Delivery Strategies for the Treatment of Onychomycosis. 61
31092174 2019
41
Detection of Trichophyton rubrum and Trichophyton interdigitale in onychomycosis using monoclonal antibodies against Sub6 (Tri r 2). 61
30152879 2019
42
Evidence that a STAT3 Mutation Causing Hyper IgE Syndrome Leads to Repression of Transcriptional Activity. 61
31737384 2019
43
Efficacy of certolizumab pegol with and without concomitant use of disease-modifying anti-rheumatic drugs over 4 years in psoriatic arthritis patients: results from the RAPID-PsA randomized controlled trial. 61
30191421 2018
44
Evaluation of relationships between onychomycosis and vascular diseases using sequential pattern mining. 61
30552340 2018
45
Update on current approaches to diagnosis and treatment of onychomycosis. 61
30411650 2018
46
Effect of Penetration Enhancers on Drug Nail Permeability from Cyclodextrin/Poloxamer-Soluble Polypseudorotaxane-Based Nail Lacquers. 61
30551601 2018
47
A Compendium of Intralesional Therapies in Nail Disorders. 61
30505775 2018
48
Imaging technique for the diagnosis of onychomatricoma. 61
29869357 2018
49
Onychopapillomas: a 68-case series to determine best surgical procedure and histologic sectioning. 61
29729116 2018
50
Dermoscopic features of onychotillomania: A study of 36 cases. 61
29660424 2018
Sources

Variations for Nail Disease

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ClinVar genetic disease variations for Nail Disease:

6 ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 POGZ NM_015100.4(POGZ):c.2771del (p.Pro924fs)deletion Pathogenic 523510 rs1553212868 1:151378740-151378740 1:151406264-151406264
2 FZD6 NM_003506.4(FZD6):c.1750G>T (p.Glu584Ter)SNV Pathogenic 30355 rs151339002 8:104342091-104342091 8:103329863-103329863
3 FZD6 NM_003506.4(FZD6):c.1531C>T (p.Arg511Cys)SNV Pathogenic 30356 rs151339003 8:104340634-104340634 8:103328406-103328406
4 46;XY;inv(6)(p22q13)dninversion Pathogenic 267941
5 SETBP1 NM_015559.3(SETBP1):c.2614G>A (p.Gly872Arg)SNV Likely pathogenic 523513 rs1555706928 18:42531919-42531919 18:44951954-44951954
6 OFD1 NM_003611.3(OFD1):c.1999G>A (p.Ala667Thr)SNV Uncertain significance 523463 rs1394450537 X:13778578-13778578 X:13760459-13760459
7 PKD1 NM_001009944.3(PKD1):c.226C>T (p.His76Tyr)SNV Uncertain significance 523385 rs932577597 16:2169369-2169369 16:2119368-2119368
Sources

Expression for Nail Disease

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Search GEO for disease gene expression data for Nail Disease.
Sources

Pathways for Nail Disease

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Pathways related to Nail Disease according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.72 STAT3 STAT1 IL22 IL17RC IL17RA IL17F
2
ERK Signaling 63
Show member pathways
 13.71 STAT3 STAT1 IL22 IL17RC IL17RA IL17A
3
PEDF Induced Signaling 63
Show member pathways
 13.59 STAT3 IL22 IL17RC IL17RA IL17F IL17A
4
TGF-Beta Pathway 63
Show member pathways
 13.46 STAT3 STAT1 IL22 IL17RC IL17A IL12RB1
5
Akt Signaling 63
Show member pathways
 13.3 STAT3 STAT1 IL22 IL17RC IL17RA IL17A
6
Cytokine Signaling in Immune system 65
Show member pathways
 13.24 STAT3 STAT1 IL22 IL17RC IL17RA IL17F
7
PAK Pathway 63
Show member pathways
 13.21 IL22 IL17RC IL17RA IL17A IL12RB1 EGFR
8
Pathways in cancer 36
12.76 STAT3 STAT1 IL12RB1 FZD6 EGFR
9
T cell receptor signaling pathway 36
Show member pathways
 12.53 STAT3 STAT1 IL17A EGFR CD4
10
Th17 cell differentiation 36
Show member pathways
 12.49 STAT3 STAT1 IL22 IL17F IL17A IL12RB1
11
Immune response IL-23 signaling pathway 22
Show member pathways
 12.45 STAT3 STAT1 IL17F IL17A IL12RB1 EGFR
12
JAK-STAT signaling pathway 36
Show member pathways
 12.38 STAT3 STAT1 IL22 IL12RB1 EGFR
13
CLEC7A (Dectin-1) signaling 65
Show member pathways
 12.34 CLEC7A CLEC6A CLEC4E CARD9
14
IL-17 Family Signaling Pathways 64
Show member pathways
 12.24 STAT3 IL17RC IL17RA IL17F IL17A
15
Tuberculosis 36
12.16 STAT1 CLEC7A CLEC4E CARD9
16
Colorectal Cancer Metastasis 63
12.12 STAT3 STAT1 FZD6 EGFR
17
C-type lectin receptor signaling pathway 36
Show member pathways
 12.11 STAT1 CLEC7A CLEC6A CLEC4E CARD9
18
Interleukin-4 and 13 signaling 65
11.93 STAT3 STAT1 IL17F IL17A
19
IL12-mediated signaling events 1
Show member pathways
 11.91 STAT3 STAT1 IL12RB1 CD4
20
ErbB1 downstream signaling 1
11.82 STAT3 STAT1 EGFR
21
CXCR4-mediated signaling events 1
11.67 STAT3 STAT1 CD4
22
IL27-mediated signaling events 1
Show member pathways
 11.66 STAT3 STAT1 IL17F IL17A IL12RB1 CD4
23
Innate Lymphoid Cells Differentiation 64
11.62 IL22 IL17A IL12RB1 CD4 CCR6
24
AGE/RAGE pathway 1
11.61 STAT3 STAT1 EGFR
25
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.4 STAT3 IL17RC IL17RA IL17F IL17A IL12RB1
26
Signaling events mediated by TCPTP 1
Show member pathways
 11.38 STAT3 STAT1 EGFR
27
Th17 Differentiation 64
Show member pathways
 11.18 STAT3 STAT1 IL22 IL17RA IL17F IL17A
28
EGF receptor (ErbB1) signaling pathway 1
11.1 STAT3 STAT1 EGFR
Sources

GO Terms for Nail Disease

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Cellular components related to Nail Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.77 STAT3 IL17RC IL17RA IL12RB1 FZD6 EGFR
2 cell surface GO:0009986 9.1 IL17RC FZD6 EGFR CLEC7A CD4 CCR6

Biological processes related to Nail Disease according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.97 IL17A CLEC4E CD4 CCR6 AIRE
2 inflammatory response GO:0006954 9.89 STAT3 IL22 IL17F IL17A CLEC7A
3 cellular response to cytokine stimulus GO:0071345 9.69 STAT3 STAT1 IL17RA
4 positive regulation of interleukin-6 secretion GO:2000778 9.61 IL17RC IL17F IL17A
5 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.6 CLEC7A CD4
6 interleukin-15-mediated signaling pathway GO:0035723 9.59 STAT3 CD4
7 interleukin-35-mediated signaling pathway GO:0070757 9.58 STAT3 STAT1
8 interleukin-27-mediated signaling pathway GO:0070106 9.58 STAT3 STAT1
9 interleukin-23-mediated signaling pathway GO:0038155 9.56 STAT3 IL12RB1
10 defense response to fungus GO:0050832 9.56 IL17RC IL17RA IL17A CLEC6A
11 cytokine-mediated signaling pathway GO:0019221 9.56 STAT3 STAT1 IL22 IL17RC IL17F IL17A
12 interleukin-9-mediated signaling pathway GO:0038113 9.55 STAT3 STAT1
13 positive regulation of interleukin-12 biosynthetic process GO:0045084 9.54 IL17A CLEC7A
14 interleukin-21-mediated signaling pathway GO:0038114 9.52 STAT3 STAT1
15 granulocyte chemotaxis GO:0071621 9.48 IL17RC IL17RA
16 positive regulation of interleukin-23 production GO:0032747 9.46 IL17RA IL17A
17 interleukin-17-mediated signaling pathway GO:0097400 9.46 IL17RC IL17RA IL17F IL17A
18 fibroblast activation GO:0072537 9.4 IL17RA IL17A
19 regulation of interleukin-6 biosynthetic process GO:0045408 9.37 IL17F CARD9
20 regulation of interleukin-2 biosynthetic process GO:0045076 9.32 IL17F CARD9
21 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.1 STAT3 IL17RC IL17RA IL17F IL17A CLEC7A

Molecular functions related to Nail Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pattern recognition receptor activity GO:0038187 9.16 CLEC7A CLEC4E
2 CCR5 chemokine receptor binding GO:0031730 8.96 STAT3 STAT1
3 interleukin-17 receptor activity GO:0030368 8.62 IL17RC IL17RA
Sources

Sources for Nail Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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