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MCID: NLD009
MIFTS: 40
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Nail Disorder, Nonsyndromic Congenital, 1
Categories:
Rare diseases, Skin diseases, Genetic diseases, Fetal diseases
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MalaCards integrated aliases for Nail Disorder, Nonsyndromic Congenital, 1:
Name: Nail Disorder, Nonsyndromic Congenital, 1
57
Characteristics:Orphanet epidemiological data:59
idiopathic trachyonychia
Inheritance: Autosomal dominant; Age of onset: Childhood; Age of death: normal life expectancy; OMIM:57
Inheritance:
autosomal dominant
Miscellaneous:
no abnormalities of skin, hair, teeth, or bones not all nails are affected in some patients HPO:32
nail disorder, nonsyndromic congenital, 1:
Inheritance autosomal dominant inheritance Onset and clinical course slow progression Classifications:
MalaCards categories:
Global: Rare diseases Genetic diseases Fetal diseases Anatomical: Skin diseases
ICD10:
34
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OMIM
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57
Many types of nonsyndromic congenital nail disorders (NDNC) have been described. Twenty-nail dystrophy (TND), also known as trachyonychia (from the Greek for 'rough nails'), is an autosomal dominant nail dystrophy characterized by excessive longitudinal striations and numerous superficial pits on the nails, which have a distinctive rough sandpaper-like appearance. Occasionally some nails are spared. The slowly progressive condition is usually apparent at birth and may be self-limiting, with spontaneous resolution in some patients (summary by Sehgal, 2007). TND is referred to here as nonsyndromic congenital nail disorder-1 (NCNC1).
(161050)
MalaCards based summary : Nail Disorder, Nonsyndromic Congenital, 1, also known as twenty-nail dystrophy, is related to alopecia universalis congenita and alopecia. An important gene associated with Nail Disorder, Nonsyndromic Congenital, 1 is FZD6 (Frizzled Class Receptor 6), and among its related pathways/superpathways is Primary immunodeficiency. The drugs Mugwort and Wormwood have been mentioned in the context of this disorder. Affiliated tissues include skin and bone, and related phenotypes are thick nail and thin nail NIH Rare Diseases : 53 Twenty-nail dystrophy is a condition that affects the nails of the fingers and toes. The nails become rough, thin, and brittle. They appear similar to sandpaper. It was once thought that all 20 nails will be affected, but any number of nails can become rough and brittle. This condition most commonly occurs in childhood, but it can occur at any age. The exact cause is often unknown, but sometimes appears with other skin conditions such as lichen planus, psoriasis and alopecia areata. In some people, the symptoms of twenty-nail dystrophy improve or disappear over time, but in other people they persist for a long time. |
Symptoms via clinical synopsis from OMIM:57Clinical features from OMIM:161050Human phenotypes related to Nail Disorder, Nonsyndromic Congenital, 1:32
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Drugs for Nail Disorder, Nonsyndromic Congenital, 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):
Interventional clinical trials:
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MalaCards organs/tissues related to Nail Disorder, Nonsyndromic Congenital, 1:41
Skin,
Bone
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Articles related to Nail Disorder, Nonsyndromic Congenital, 1:(show all 43)
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Genes related to Nail Disorder, Nonsyndromic Congenital, 1 (0 elite genes):
- Elite gene
- Cancer Census gene in COSMIC
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Search
GEO
for disease gene expression data for Nail Disorder, Nonsyndromic Congenital, 1.
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Biological processes related to Nail Disorder, Nonsyndromic Congenital, 1 according to GeneCards Suite gene sharing:
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