MCID: NRC003
MIFTS: 29

Narcissistic Personality Disorder

Categories: Mental diseases

Aliases & Classifications for Narcissistic Personality Disorder

MalaCards integrated aliases for Narcissistic Personality Disorder:

Name: Narcissistic Personality Disorder 12 74 54 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:2745
ICD9CM 34 301.81
MeSH 43 D010554
NCIt 49 C92635
SNOMED-CT 67 80711002
ICD10 32 F60.81
UMLS 71 C0027402

Summaries for Narcissistic Personality Disorder

Disease Ontology : 12 A personality disorder that involves an excessive preoccupation with issues of personal adequacy, power, prestige and vanity.

MalaCards based summary : Narcissistic Personality Disorder is related to avoidant personality disorder and antisocial personality disorder. An important gene associated with Narcissistic Personality Disorder is WASF2 (WASP Family Member 2), and among its related pathways/superpathways is Salmonella infection (KEGG). Affiliated tissues include brain and testes, and related phenotype is Increased transferrin (TF) endocytosis.

Wikipedia : 74 Narcissistic personality disorder (NPD) is a personality disorder characterized by a long-term pattern... more...

Related Diseases for Narcissistic Personality Disorder

Diseases related to Narcissistic Personality Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 avoidant personality disorder 30.2 WASF2 WASF1 TTF2 PIR CLPS
2 antisocial personality disorder 30.0 WASF2 WASF1 TTF2 PIR
3 disease of mental health 29.9 WASF2 WASF1 ADAMTS2
4 mental depression 29.8 WASF2 WASF1
5 histrionic personality disorder 29.7 WASF2 WASF1 SMPD1 PIR
6 phobia, specific 29.5 WASF2 WASF1 NT5M
7 dysthymic disorder 29.1 WASF2 WASF1 PIR NT5M
8 obsessive-compulsive personality disorder 28.7 WASF2 WASF1 PIR NT5M CLPS
9 schizotypal personality disorder 28.6 WASF2 WASF1 PIR NT5M CLPS
10 exhibitionism 28.4 PIR OSTF1 NT5M CHST15 ADAMTS2
11 personality disorder 11.1
12 borderline personality disorder 10.6
13 severe combined immunodeficiency 10.3
14 barbiturate abuse 10.2 WASF2 WASF1
15 major affective disorder 8 10.2
16 major affective disorder 9 10.2
17 bipolar disorder 10.2
18 mood disorder 10.2
19 depression 10.2
20 hallucinogen dependence 10.2 WASF2 WASF1
21 separation anxiety disorder 10.2 WASF2 WASF1
22 cannabis abuse 10.1 WASF2 WASF1
23 oppositional defiant disorder 10.1 WASF2 WASF1
24 alcohol dependence 10.0
25 hand skill, relative 10.0
26 attention deficit-hyperactivity disorder 10.0
27 obsessive-compulsive disorder 10.0
28 frontotemporal dementia 10.0
29 anorexia nervosa 10.0
30 bulimia nervosa 10.0
31 anxiety 10.0
32 major depressive disorder 10.0
33 pervasive developmental disorder 10.0
34 hypochondriasis 10.0
35 dementia 10.0
36 bipolar i disorder 10.0
37 generalized anxiety disorder 10.0
38 alcohol use disorder 10.0
39 factitious disorder 10.0
40 post-traumatic stress disorder 10.0
41 substance abuse 10.0
42 neurotic disorder 10.0
43 acute stress disorder 10.0
44 drug dependence 10.0
45 pseudobulbar affect 10.0
46 agoraphobia 10.0 WASF2 WASF1 PIR
47 social phobia 10.0 WASF2 WASF1
48 anosognosia 9.8 NT5M ADAMTS2
49 larsen syndrome 9.7 FLNA CHST15
50 dependent personality disorder 9.7 WASF2 WASF1 PIR CLPS

Comorbidity relations with Narcissistic Personality Disorder via Phenotypic Disease Network (PDN):


Anxiety Dependent Personality Disorder
Dysthymic Disorder Histrionic Personality Disorder
Hypertension, Essential Major Depressive Disorder

Graphical network of the top 20 diseases related to Narcissistic Personality Disorder:



Diseases related to Narcissistic Personality Disorder

Symptoms & Phenotypes for Narcissistic Personality Disorder

GenomeRNAi Phenotypes related to Narcissistic Personality Disorder according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased transferrin (TF) endocytosis GR00363-A 9.23 ADAMTS2 CHST15 CLPS NT5M OSTF1 PIR

Drugs & Therapeutics for Narcissistic Personality Disorder

Search Clinical Trials , NIH Clinical Center for Narcissistic Personality Disorder

Genetic Tests for Narcissistic Personality Disorder

Anatomical Context for Narcissistic Personality Disorder

MalaCards organs/tissues related to Narcissistic Personality Disorder:

40
Brain, Testes

Publications for Narcissistic Personality Disorder

Articles related to Narcissistic Personality Disorder:

(show top 50) (show all 308)
# Title Authors PMID Year
1
An examination of the factor structure of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, narcissistic personality disorder criteria: one or two factors? 54 61
18243885 2008
2
Characterological depression in patients with narcissistic personality disorder. 61
31517547 2019
3
Aspects of extraversion and their associations with psychopathology. 61
31414831 2019
4
Does Religiosity Reduce Narcissistic Personality Disorder? Examining the Case of Muslim University Students. 61
29691791 2019
5
Facial Emotion Recognition and Social-Cognitive Correlates of Narcissistic Features. 61
29847219 2019
6
Mom-and-Pop Narcissism: The Impact of Attention Seeking and Grandiosity on Couples' Experience of the Transition to Parenthood. 61
31403369 2019
7
Trust and Rejection Sensitivity in Personality Disorders. 61
31264030 2019
8
Frequency of narcissistic personality disorder in a counseling center population in China. 61
31277613 2019
9
A parallel process latent growth model of narcissistic personality disorder symptoms and normal personality traits. 61
30556721 2019
10
Disorder of the personality: a possible factor of risk for the dementia. 61
31017274 2019
11
A Potential Tension in DSM-5: The General Definition of Mental Disorder versus Some Specific Diagnostic Criteria. 61
29850842 2019
12
[Comparison of Kernbergs and Kohuts Theory of Narcissistic Personality Disorder]. 61
31487379 2019
13
Narcissistic Implications in Gambling Disorder: The Mediating Role of Emotion Dysregulation. 61
29455443 2018
14
Impostors and Impersonators: Fake Health Practitioners and the Law. 61
30574727 2018
15
Personality Disorders among Individuals Seeking Cosmetic Botulinum Toxin Type A (BoNTA) Injection, a Cross-Sectional Study. 61
30515036 2018
16
Clinical Characteristics of Comorbid Narcissistic Personality Disorder in Patients With Borderline Personality Disorder. 61
28758884 2018
17
Comparing self-report measures of grandiose narcissism, vulnerable narcissism, and narcissistic personality disorder in a male offender sample. 61
29792507 2018
18
Narcissist or narcissistic? Evaluation of the latent structure of narcissistic personality disorder. 61
30010367 2018
19
"Validation of the Narcissistic Grandiosity Scale and creation of reduced item variants": Correction to Crowe et al. (2016). 61
29975086 2018
20
A Comparison of the Nomological Networks Associated With Forced-Choice and Likert Formats of the Narcissistic Personality Inventory. 61
28436690 2018
21
Clinician ratings of vulnerable and grandiose narcissistic features: Implications for an expanded narcissistic personality disorder diagnosis. 61
29215903 2018
22
Psychological Factors Including Demographic Features, Mental Illnesses, and Personality Disorders as Predictors in Internet Addiction Disorder. 61
29997655 2018
23
The role of shame and self-compassion in psychotherapy for narcissistic personality disorder: An exploratory study. 61
29265698 2018
24
Quasi-psychosis in covert Narcissistic Personality Disorder-A case report. 61
29272784 2018
25
Examining sex differences in DSM-IV-TR narcissistic personality disorder symptom expression using Item Response Theory (IRT). 61
29291575 2018
26
Narcissistic Rage and the Murder of Allison Baden-Clay. 61
31984012 2018
27
Symptom severity and mindreading in narcissistic personality disorder. 61
30110368 2018
28
Brain functional integration: an epidemiologic study on stress-producing dissociative phenomena. 61
29296086 2018
29
Grandiose and Vulnerable Narcissism in Borderline Personality Disorder. 61
29466803 2018
30
Malignant Narcissism in Relation to Clinical Change in Borderline Personality Disorder: An Exploratory Study. 61
30184541 2018
31
Training in Good Psychiatric Management for Borderline Personality Disorder in Residency: An Aide to Learning Supportive Psychotherapy for Challenging-to-Treat Patients. 61
29809114 2018
32
An Analysis of Self: The Development and Assessment of a Measure of Selfobject Needs. 61
28631972 2017
33
A passionate call for dispassionate conclusion: Comment on Fossati et al. (2016). 61
29154600 2017
34
On studying narcissism in personality inventories rather than the Narcissistic Personality Inventory: Reply to Miller and Lynam (2017). 61
29154601 2017
35
Profiling pathological narcissism according to DSM-5 domains and traits: A study on consecutively admitted Italian psychotherapy patients. 61
27336839 2017
36
"Profiling pathological narcissism according to DSM-5 domains and traits: A study on consecutively admitted Italian psychotherapy Patients": Correction to Fossati et al. (2016). 61
27893225 2017
37
Narcissistic Personality Disorder and the Structure of Common Mental Disorders. 61
27617650 2017
38
Narcissistic Personality Disorder in Clinical Health Psychology Practice: Case Studies of Comorbid Psychological Distress and Life-Limiting Illness. 61
28767013 2017
39
Countertransference when working with narcissistic personality disorder: An empirical investigation. 61
28581327 2017
40
Controversies in Narcissism. 61
28301765 2017
41
Narcissistic Personality Disorder and suicidal behavior in mood disorders. 61
27816770 2017
42
Intersect between self-esteem and emotion regulation in narcissistic personality disorder - implications for alliance building and treatment. 61
28191317 2017
43
Validation of the Narcissistic Grandiosity Scale and creation of reduced item variants. 61
27046276 2016
44
Borderline Personality Disorder and Narcissistic Personality Disorder Diagnoses From the Perspective of the DSM-5 Personality Traits: A Study on Italian Clinical Participants. 61
27660996 2016
45
Clinical features and psychiatric comorbidities of borderline personality disorder patients with versus without a history of suicide attempt. 61
27728869 2016
46
Brittle diabetes: Psychopathology and personality. 61
27524279 2016
47
Fluctuation between grandiose and vulnerable narcissism. 61
26986960 2016
48
Personality and Perpetration: Narcissism Among College Sexual Assault Perpetrators. 61
26712237 2016
49
Narcissistic personality disorder and suicide. 61
27658843 2016
50
Mental health literacy in Hong Kong. 61
27261468 2016

Variations for Narcissistic Personality Disorder

Expression for Narcissistic Personality Disorder

Search GEO for disease gene expression data for Narcissistic Personality Disorder.

Pathways for Narcissistic Personality Disorder

Pathways related to Narcissistic Personality Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.7 WASF2 WASF1 FLNA

GO Terms for Narcissistic Personality Disorder

Cellular components related to Narcissistic Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 actin cytoskeleton GO:0015629 9.13 WASF2 WASF1 FLNA
2 SCAR complex GO:0031209 8.62 WASF2 WASF1

Biological processes related to Narcissistic Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 digestion GO:0007586 9.16 PIR CLPS
2 actin cytoskeleton organization GO:0030036 9.13 WASF2 WASF1 FLNA
3 Rac protein signal transduction GO:0016601 8.62 WASF2 WASF1

Molecular functions related to Narcissistic Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 actin binding GO:0003779 9.33 WASF2 WASF1 FLNA
2 Rac GTPase binding GO:0048365 8.96 WASF1 FLNA
3 protein kinase A binding GO:0051018 8.62 WASF2 WASF1

Sources for Narcissistic Personality Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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