MCID: NRC003
MIFTS: 30

Narcissistic Personality Disorder

Categories: Mental diseases

Aliases & Classifications for Narcissistic Personality Disorder

MalaCards integrated aliases for Narcissistic Personality Disorder:

Name: Narcissistic Personality Disorder 12 74 54 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:2745
ICD9CM 34 301.81
MeSH 43 D010554
NCIt 49 C92635
SNOMED-CT 67 80711002
ICD10 32 F60.81
UMLS 71 C0027402

Summaries for Narcissistic Personality Disorder

Disease Ontology : 12 A personality disorder that involves an excessive preoccupation with issues of personal adequacy, power, prestige and vanity.

MalaCards based summary : Narcissistic Personality Disorder is related to avoidant personality disorder and disease of mental health. An important gene associated with Narcissistic Personality Disorder is WASF2 (WASP Family Member 2). Affiliated tissues include brain and testes, and related phenotype is liver/biliary system.

Wikipedia : 74 Narcissistic personality disorder (NPD) is a personality disorder characterized by a long-term pattern... more...

Related Diseases for Narcissistic Personality Disorder

Diseases related to Narcissistic Personality Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 avoidant personality disorder 30.3 WASF2 WASF1 TTF2 PIR CLPS
2 disease of mental health 30.0 WASF2 WASF1 ADAMTS2
3 histrionic personality disorder 29.8 WASF2 WASF1 SMPD1 PIR
4 hypochondriasis 29.8 PIR CFI
5 neurotic disorder 29.7 MFSD8 FLNA
6 obsessive-compulsive personality disorder 29.7 WASF2 WASF1 PIR CLPS
7 schizotypal personality disorder 29.7 WASF2 WASF1 PIR CLPS
8 phobia, specific 29.6 WASF2 WASF1 CFI
9 dysthymic disorder 29.2 WASF2 WASF1 PIR CFI
10 antisocial personality disorder 29.2 WASF2 WASF1 TTF2 PIR CFI
11 exhibitionism 28.6 PIR OSTF1 CHST15 CFI ADAMTS2
12 personality disorder 11.2
13 borderline personality disorder 10.6
14 severe combined immunodeficiency 10.3
15 barbiturate abuse 10.3 WASF2 WASF1
16 hallucinogen dependence 10.3 WASF2 WASF1
17 separation anxiety disorder 10.2 WASF2 WASF1
18 cannabis abuse 10.2 WASF2 WASF1
19 major affective disorder 8 10.2
20 major affective disorder 9 10.2
21 bipolar disorder 10.2
22 mood disorder 10.2
23 depression 10.2
24 spinocerebellar ataxia, autosomal recessive 3 10.1 WASF2 WASF1
25 ring dermoid of cornea 10.1 WASF2 WASF1
26 alcohol dependence 10.0
27 hand skill, relative 10.0
28 attention deficit-hyperactivity disorder 10.0
29 obsessive-compulsive disorder 10.0
30 frontotemporal dementia 10.0
31 anorexia nervosa 10.0
32 bulimia nervosa 10.0
33 anxiety 10.0
34 major depressive disorder 10.0
35 pervasive developmental disorder 10.0
36 dementia 10.0
37 bipolar i disorder 10.0
38 generalized anxiety disorder 10.0
39 alcohol use disorder 10.0
40 mental depression 10.0
41 factitious disorder 10.0
42 post-traumatic stress disorder 10.0
43 substance abuse 10.0
44 acute stress disorder 10.0
45 drug dependence 10.0
46 pseudobulbar affect 10.0
47 cannabis dependence 10.0 WASF2 WASF1
48 ceroid lipofuscinosis, neuronal, 6 10.0 SMPD1 MFSD8
49 oppositional defiant disorder 9.7 WASF2 WASF1 CFI
50 social phobia 9.7 WASF2 WASF1 CFI

Comorbidity relations with Narcissistic Personality Disorder via Phenotypic Disease Network (PDN):


Anxiety Dependent Personality Disorder
Dysthymic Disorder Histrionic Personality Disorder
Hypertension, Essential Major Depressive Disorder

Graphical network of the top 20 diseases related to Narcissistic Personality Disorder:



Diseases related to Narcissistic Personality Disorder

Symptoms & Phenotypes for Narcissistic Personality Disorder

MGI Mouse Phenotypes related to Narcissistic Personality Disorder:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.02 FLNA MFSD8 SMPD1 WASF1 WASF2

Drugs & Therapeutics for Narcissistic Personality Disorder

Search Clinical Trials , NIH Clinical Center for Narcissistic Personality Disorder

Genetic Tests for Narcissistic Personality Disorder

Anatomical Context for Narcissistic Personality Disorder

MalaCards organs/tissues related to Narcissistic Personality Disorder:

40
Brain, Testes

Publications for Narcissistic Personality Disorder

Articles related to Narcissistic Personality Disorder:

(show top 50) (show all 324)
# Title Authors PMID Year
1
An examination of the factor structure of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, narcissistic personality disorder criteria: one or two factors? 61 54
18243885 2008
2
Understanding empathy and its disorders through a focus on the neural mechanism. 61
32278184 2020
3
The Positive Aspects of Attention-Deficit/Hyperactivity Disorder among Famous People. 61
32321205 2020
4
Narcissistic personality disorder: Challenges and therapeutic alliance in primary care. 61
32332228 2020
5
Pseudologia Fantastica: An Elaborate Tale of Combat-related PTSD. 61
32421295 2020
6
Examining the Criterion Validity and Diagnostic Specificity of Self-Report Measures of Narcissism and Mania. 61
32363899 2020
7
Internal Processing in Patients With Pathological Narcissism or Narcissistic Personality Disorder: Implications for Alliance Building and Therapeutic Strategies. 61
32186980 2020
8
Clinician Emotional Responses and Therapeutic Alliance When Treating Adolescent Patients With Narcissistic Personality Disorder Subtypes: A Clinically Meaningful Empirical Investigation. 61
32186983 2020
9
Processes of Change in Psychotherapy for Narcissistic Personality Disorder. 61
32186979 2020
10
Introduction to the Special Issue on Narcissistic Personality Disorder. 61
32186982 2020
11
Commentary on the Special Issue: Narcissistic Personality Disorder: A Coming of Age. 61
32186984 2020
12
Dos and Don'ts in Treatments of Patients With Narcissistic Personality Disorder. 61
32186986 2020
13
Commentary on the Special Issue: Complexity, Pleomorphism, and Dynamic Processes in Narcissistic Personality Disorder. 61
32186991 2020
14
Perfectionism, Shame, and Aggression in Depressive Patients With Narcissistic Personality Disorder. 61
32186981 2020
15
Diagnosis, Classification, and Assessment of Narcissistic Personality Disorder Within the Framework of Object Relations Theory. 61
32186989 2020
16
Principles of Psychodynamic Treatment for Patients With Narcissistic Personality Disorder. 61
32186987 2020
17
Transference-Focused Psychotherapy for Narcissistic Personality Disorder: An Object Relations Approach. 61
32186988 2020
18
Characterological depression in patients with narcissistic personality disorder. 61
31517547 2019
19
Aspects of extraversion and their associations with psychopathology. 61
31414831 2019
20
Does Religiosity Reduce Narcissistic Personality Disorder? Examining the Case of Muslim University Students. 61
29691791 2019
21
Facial Emotion Recognition and Social-Cognitive Correlates of Narcissistic Features. 61
29847219 2019
22
Mom-and-Pop Narcissism: The Impact of Attention Seeking and Grandiosity on Couples' Experience of the Transition to Parenthood. 61
31403369 2019
23
Trust and Rejection Sensitivity in Personality Disorders. 61
31264030 2019
24
Frequency of narcissistic personality disorder in a counseling center population in China. 61
31277613 2019
25
A parallel process latent growth model of narcissistic personality disorder symptoms and normal personality traits. 61
30556721 2019
26
Disorder of the personality: a possible factor of risk for the dementia. 61
31017274 2019
27
A Potential Tension in DSM-5: The General Definition of Mental Disorder versus Some Specific Diagnostic Criteria. 61
29850842 2019
28
[Comparison of Kernbergs and Kohuts Theory of Narcissistic Personality Disorder]. 61
31487379 2019
29
Impostors and Impersonators: Fake Health Practitioners and the Law. 61
30574727 2018
30
Narcissistic Implications in Gambling Disorder: The Mediating Role of Emotion Dysregulation. 61
29455443 2018
31
Personality Disorders among Individuals Seeking Cosmetic Botulinum Toxin Type A (BoNTA) Injection, a Cross-Sectional Study. 61
30515036 2018
32
Clinical Characteristics of Comorbid Narcissistic Personality Disorder in Patients With Borderline Personality Disorder. 61
28758884 2018
33
Narcissist or narcissistic? Evaluation of the latent structure of narcissistic personality disorder. 61
30010367 2018
34
Comparing self-report measures of grandiose narcissism, vulnerable narcissism, and narcissistic personality disorder in a male offender sample. 61
29792507 2018
35
"Validation of the Narcissistic Grandiosity Scale and creation of reduced item variants": Correction to Crowe et al. (2016). 61
29975086 2018
36
A Comparison of the Nomological Networks Associated With Forced-Choice and Likert Formats of the Narcissistic Personality Inventory. 61
28436690 2018
37
Clinician ratings of vulnerable and grandiose narcissistic features: Implications for an expanded narcissistic personality disorder diagnosis. 61
29215903 2018
38
Psychological Factors Including Demographic Features, Mental Illnesses, and Personality Disorders as Predictors in Internet Addiction Disorder. 61
29997655 2018
39
The role of shame and self-compassion in psychotherapy for narcissistic personality disorder: An exploratory study. 61
29265698 2018
40
Quasi-psychosis in covert Narcissistic Personality Disorder-A case report. 61
29272784 2018
41
Examining sex differences in DSM-IV-TR narcissistic personality disorder symptom expression using Item Response Theory (IRT). 61
29291575 2018
42
Narcissistic Rage and the Murder of Allison Baden-Clay. 61
31984012 2018
43
Symptom severity and mindreading in narcissistic personality disorder. 61
30110368 2018
44
Malignant Narcissism in Relation to Clinical Change in Borderline Personality Disorder: An Exploratory Study. 61
30184541 2018
45
Brain functional integration: an epidemiologic study on stress-producing dissociative phenomena. 61
29296086 2018
46
Grandiose and Vulnerable Narcissism in Borderline Personality Disorder. 61
29466803 2018
47
Training in Good Psychiatric Management for Borderline Personality Disorder in Residency: An Aide to Learning Supportive Psychotherapy for Challenging-to-Treat Patients. 61
29809114 2018
48
On studying narcissism in personality inventories rather than the Narcissistic Personality Inventory: Reply to Miller and Lynam (2017). 61
29154601 2017
49
Profiling pathological narcissism according to DSM-5 domains and traits: A study on consecutively admitted Italian psychotherapy patients. 61
27336839 2017
50
"Profiling pathological narcissism according to DSM-5 domains and traits: A study on consecutively admitted Italian psychotherapy Patients": Correction to Fossati et al. (2016). 61
27893225 2017

Variations for Narcissistic Personality Disorder

Expression for Narcissistic Personality Disorder

Search GEO for disease gene expression data for Narcissistic Personality Disorder.

Pathways for Narcissistic Personality Disorder

GO Terms for Narcissistic Personality Disorder

Cellular components related to Narcissistic Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 actin cytoskeleton GO:0015629 9.13 WASF2 WASF1 FLNA
2 SCAR complex GO:0031209 8.62 WASF2 WASF1

Biological processes related to Narcissistic Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 actin cytoskeleton organization GO:0030036 9.43 WASF2 WASF1 FLNA
2 digestion GO:0007586 9.32 PIR CLPS
3 Rac protein signal transduction GO:0016601 9.16 WASF2 WASF1
4 positive regulation of Arp2/3 complex-mediated actin nucleation GO:2000601 8.96 WASF2 WASF1
5 lamellipodium morphogenesis GO:0072673 8.62 WASF2 WASF1

Molecular functions related to Narcissistic Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Rac GTPase binding GO:0048365 9.26 WASF1 FLNA
2 protein kinase A regulatory subunit binding GO:0034237 9.16 WASF2 WASF1
3 protein kinase A binding GO:0051018 8.96 WASF2 WASF1
4 Arp2/3 complex binding GO:0071933 8.62 WASF2 WASF1

Sources for Narcissistic Personality Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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