Narcolepsy 1 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

NRCLP1 MCID: NRC009 MIFTS: 44	Narcolepsy 1 (NRCLP1) Categories: Eye diseases, Genetic diseases, Mental diseases, Muscle diseases, Neuronal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Expand all tables

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Aliases & Classifications for Narcolepsy 1

MalaCards integrated aliases for Narcolepsy 1:

Name: Narcolepsy 1 ⁵⁷ ⁷² ²⁹ ¹³ ⁶ ⁷⁰

Narcolepsy-Cataplexy Syndrome ⁷² ⁷⁰

Narcoleptic Syndrome 1 ⁵⁷ ⁷²

Nrclp1 ⁵⁷ ⁷²

Narcolepsy-Cataplexy ⁵⁸

Narcolepsy, Type 1 ³⁹

Narcolepsy Type 1 ⁵⁸

Gelineau Disease ⁵⁸

Characteristics:

Orphanet epidemiological data:

⁵⁸

narcolepsy type 1
Prevalence: 1-5/10000 (Europe),1-5/10000 (Norway),1-5/10000 (Finland),1-5/10000 (China); Age of onset: Adolescent,Adult,Childhood; Age of death: normal life expectancy;

OMIM®:

⁵⁷ (Updated 20-May-2021)

Inheritance:
autosomal dominant

Miscellaneous:
genetic heterogeneity
onset usually in second decade of life, although earlier and later onset have been reported
prevalence of approximately 1 in 2000 individuals
mutation in the hcrt gene has been identified in 1 patient

HPO:

³¹

narcolepsy 1:
Inheritance autosomal dominant inheritance heterogeneous

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Neuronal diseases Mental diseases Eye diseases Muscle diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the nervous system

Episodic and paroxysmal disorders

Sleep disorders

Narcolepsy and cataplexy

Orphanet: ⁵⁸

Rare neurological diseases

External Ids:

OMIM® ⁵⁷ 161400

OMIM Phenotypic Series ⁵⁷ PS161400

MeSH ⁴⁴ D009290

MESH via Orphanet ⁴⁵ D009290

ICD10 via Orphanet ³³ G47.4

UMLS via Orphanet ⁷¹ C0027404 C0751362

Orphanet ⁵⁸ ORPHA2073

MedGen ⁴¹ C0007384 C1834372

SNOMED-CT via HPO ⁶⁸ 230736007 263681008 271594007 more

UMLS ⁷⁰ C0751362 C1834372

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Summaries for Narcolepsy 1

OMIM® : ⁵⁷ Adie (1926) first delineated narcolepsy as a separate and specific entity. It is a sleep disorder characterized by attacks of disabling daytime drowsiness and low alertness. The normal physiologic components of rapid eye movement (REM) sleep, dreaming and loss of muscle tone, are separated and also occur while the subject is awake, resulting in half-sleep dreams and episodes of skeletal muscle paralysis and atonia (cataplexy and sleep paralysis). Unlike normal sleep, that of narcolepsy often begins with REM activity and the time taken to fall asleep is shorter than normal. In contrast to animal models, human narcolepsy is not a simple genetic disorder. Most human cases of narcolepsy are sporadic and carry a specific HLA haplotype (Peyron et al., 2000). Familial cases are the exception rather than the rule, and monozygotic twins show only partial concordance (25 to 31%) (Mignot, 1998). (161400) (Updated 20-May-2021)

MalaCards based summary : Narcolepsy 1, also known as narcolepsy-cataplexy syndrome, is related to hypersomnia and idiopathic hypersomnia, and has symptoms including excessive daytime somnolence and hallucinations, hypnagogic. An important gene associated with Narcolepsy 1 is HCRT (Hypocretin Neuropeptide Precursor), and among its related pathways/superpathways are G-protein signaling N-RAS regulation pathway and MHC class II antigen presentation. Affiliated tissues include eye, skeletal muscle and hypothalamus, and related phenotypes are hallucinations and cataplexy

UniProtKB/Swiss-Prot : ⁷² Narcolepsy 1: Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid- eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed.

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Related Diseases for Narcolepsy 1

Diseases in the Narcolepsy family:

Narcolepsy 1	Narcolepsy 2
Narcolepsy 3	Narcolepsy 4
Narcolepsy 5	Narcolepsy 6
Narcolepsy 7

Diseases related to Narcolepsy 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)

#	Related Disease	Score	Top Affiliating Genes
1	hypersomnia	30.3	HLA-DRB1 HLA-DQB1 HCRT
2	idiopathic hypersomnia	30.0	HLA-DRB1 HLA-DQB1 HCRT
3	acute disseminated encephalomyelitis	29.6	MOG HLA-DRB1 HLA-DQB1 HCRT
4	guillain-barre syndrome	29.6	MOG HLA-DRB1 HLA-DQB1 HCRT
5	narcolepsy	27.4	ZNF365 TNFSF4 P2RY11 MOG HLA-DRB1 HLA-DQB1
6	cerebellar ataxia, deafness, and narcolepsy, autosomal dominant	11.4
7	narcolepsy 7	11.3
8	sleep disorder	10.3
9	autonomic dysfunction	10.2
10	kleine-levin hibernation syndrome	10.2	HLA-DQB1 HCRT
11	recurrent hypersomnia	10.2	HLA-DQB1 HCRT
12	constipation	10.2
13	precocious puberty	10.2
14	seizure disorder	10.2
15	tremor	10.2
16	benign idiopathic neonatal seizures	10.2
17	body mass index quantitative trait locus 1	10.2
18	limbic encephalitis with lgi1 antibodies	10.1	HLA-DRB1 HLA-DQB1
19	autoimmune polyglandular syndrome type 3	10.1	HLA-DRB1 HLA-DQB1
20	htlv-1 associated myelopathy/tropical spastic paraparesis	10.1	HLA-DRB1 HLA-DQB1
21	latent autoimmune diabetes in adults	10.1	HLA-DRB1 HLA-DQB1
22	occupational asthma	10.1	HLA-DRB1 HLA-DQB1
23	primary adrenal insufficiency	10.1	HLA-DRB1 HLA-DQB1
24	recurrent respiratory papillomatosis	10.1	HLA-DRB1 HLA-DQB1
25	autoimmune disease	10.1
26	schizophrenia	10.1
27	restless legs syndrome	10.1
28	amnestic disorder	10.1
29	epilepsy	10.1
30	chronic pain	10.1
31	beryllium disease	10.1	HLA-DRB1 HLA-DQB1
32	apple allergy	10.1	HLA-DRB1 HLA-DQB1
33	helix syndrome	10.1
34	rem sleep behavior disorder	10.1
35	rare sleep disorder	10.1
36	chronic beryllium disease	10.1	HLA-DRB1 HLA-DQB1
37	metal allergy	10.1	HLA-DRB1 HLA-DQB1
38	autoimmune hepatitis type 1	10.1	HLA-DRB1 HLA-DQB1
39	focal epithelial hyperplasia	10.1	HLA-DRB1 HLA-DQB1
40	podoconiosis	10.1	HLA-DRB1 HLA-DQB1
41	pemphigoid	10.1	HLA-DRB1 HLA-DQB1
42	osteonecrosis of the jaw	10.0	HLA-DRB1 HLA-DQB1
43	pityriasis rosea	10.0	HLA-DRB1 HLA-DQB1
44	oligoarticular juvenile idiopathic arthritis	10.0	HLA-DRB1 HLA-DQB1
45	idiopathic nephrotic syndrome	10.0	HLA-DRB1 HLA-DQB1
46	ocular cicatricial pemphigoid	10.0	HLA-DRB1 HLA-DQB1
47	cicatricial pemphigoid	10.0	HLA-DRB1 HLA-DQB1
48	alveolar echinococcosis	10.0	HLA-DRB1 HLA-DQB1
49	paraneoplastic pemphigus	10.0	HLA-DRB1 HLA-DQB1
50	cytomegalovirus retinitis	10.0	HLA-DRB1 HLA-DQB1

Graphical network of the top 20 diseases related to Narcolepsy 1:

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Symptoms & Phenotypes for Narcolepsy 1

Human phenotypes related to Narcolepsy 1:

⁵⁸ ³¹ (show all 16)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	hallucinations ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0000738
2	cataplexy ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0002524
3	transient global amnesia ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0010534
4	excessive daytime somnolence ³¹	hallmark (90%)		HP:0001262
5	abnormality of vision ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0000504
6	abnormal rapid eye movement sleep ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002494
7	slurred speech ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0001350
8	obesity ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0001513
9	syncope ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0001279
10	sleep disturbance ⁵⁸		Very frequent (99-80%)
11	abnormality of the eye ⁵⁸		Frequent (79-30%)
12	narcolepsy ³¹			HP:0030050
13	excessive daytime sleepiness ⁵⁸		Very frequent (99-80%)
14	paroxysmal drowsiness ³¹			HP:0002330
15	hypnagogic hallucinations ³¹			HP:0002519
16	hypnopompic hallucinations ³¹			HP:0006896

Symptoms via clinical synopsis from OMIM®:

⁵⁷ (Updated 20-May-2021)

Neurologic Central Nervous System:
excessive daytime sleepiness
hypnagogic hallucinations
hypnopompic hallucinations
cataplexy, paroxysmal weakness or paralysis
cataplexy often triggered by strong emotions
more

Laboratory Abnormalities:
hla-dqw6 association (dqb1*0602)
decreased levels of csf hypocretin (hcrt, )

Growth Weight:
rapid weight gain may occur

Clinical features from OMIM®:

161400 (Updated 20-May-2021)

UMLS symptoms related to Narcolepsy 1:

excessive daytime somnolence; hallucinations, hypnagogic

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Drugs & Therapeutics for Narcolepsy 1

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Randomized, Double-Blind, Placebo-Controlled, Multiple Rising Oral Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of TAK-994 in Patients With Narcolepsy With or Without Cataplexy (Narcolepsy Type 1 or Narcolepsy Type 2)	Recruiting	NCT04096560	Phase 2	TAK-994;Placebo
2	A Dose-Blind Extension Study With Double-blind, Placebo-Controlled, Randomized Withdrawal Period to Evaluate the Safety and Explore the Pharmacokinetics and Pharmacodynamics of TAK-994 in Adults With Narcolepsy With Cataplexy (Narcolepsy Type 1)	Not yet recruiting	NCT04820842	Phase 2	TAK-994;Placebo
3	The Role of the Circadian System in Neurological Sleep-wake Disorders: Assessment of Circadian and Homeostatic Sleep-wake Regulation and Vigilance With a Poly-nap Protocol	Completed	NCT03356938
4	Microglial Activation in Narcolepsy Type 1 and Kleine-Levin Syndrome: Positron Emission Tomography (PET) Study in [18F] DPA-714	Recruiting	NCT03754348
5	A Study to Assess the Frequency and Characteristics of Wake and Sleep State Transitions Over Multiple Nights in Subjects With Narcolepsy Type 1 Compared With Healthy Subjects Using a Portable Electroencephalogram Device	Recruiting	NCT04445129

Search NIH Clinical Center for Narcolepsy 1

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Genetic Tests for Narcolepsy 1

Genetic tests related to Narcolepsy 1:

#	Genetic test	Affiliating Genes
1	Narcolepsy 1 ²⁹	HCRT

Sources

Anatomical Context for Narcolepsy 1

MalaCards organs/tissues related to Narcolepsy 1:

⁴⁰

Eye, Skeletal Muscle, Hypothalamus, T Cells, Heart, Ovary, Temporal Lobe

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Publications for Narcolepsy 1

Articles related to Narcolepsy 1:

(show top 50) (show all 53)

#	Title	Authors	PMID	Year
1	A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. ⁶ ⁵⁷	Peyron C...Mignot E	10973318	2000
2	T cells in patients with narcolepsy target self-antigens of hypocretin neurons. ⁵⁷	Latorre D...Sallusto F	30232458	2018
3	A missense mutation in myelin oligodendrocyte glycoprotein as a cause of familial narcolepsy with cataplexy. ⁶	Hor H...Peraita-Adrados R	21907016	2011
4	Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy. ⁵⁷	Hor H...Tafti M	20711174	2010
5	Normalization of hypocretin-1 in narcolepsy after intravenous immunoglobulin treatment. ⁵⁷	Dauvilliers Y...Tafti M	19841387	2009
6	Narp immunostaining of human hypocretin (orexin) neurons: loss in narcolepsy. ⁵⁷	Blouin AM...Siegel JM	16135770	2005
7	Concomitant loss of dynorphin, NARP, and orexin in narcolepsy. ⁵⁷	Crocker A...Scammell TE	16247044	2005
8	A functional autoantibody in narcolepsy. ⁵⁷	Smith AJ...Gordon TP	15589310	2004
9	CSF hypocretin-1 (orexin-A) levels in childhood narcolepsy and neurologic disorders. ⁵⁷	Arii J...Nishino S	15623725	2004
10	A monozygotic twin pair discordant for narcolepsy and CSF hypocretin-1. ⁵⁷	Dauvilliers Y...Tafti M	15184641	2004
11	Monozygotic twins concordant for narcolepsy-cataplexy without any detectable abnormality in the hypocretin (orexin) pathway. ⁵⁷	Khatami R...Bassetti CL	15081654	2004
12	Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy. ⁵⁷	Siebold C...Fugger L	14769912	2004
13	Age at onset of narcolepsy in two large populations of patients in France and Quebec. ⁵⁷	Dauvilliers Y...Billiard M	11739821	2001
14	Normal plasma levels of orexin A (hypocretin-1) in narcoleptic patients. ⁵⁷	Dalal MA...Pollmacher T	11425946	2001
15	Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. ⁵⁷	Mignot E...Risch N	11179016	2001
16	Reduced number of hypocretin neurons in human narcolepsy. ⁵⁷	Thannickal TC...Siegel JM	11055430	2000
17	Hypocretin (orexin) deficiency in human narcolepsy. ⁵⁷	Nishino S...Mignot E	10615891	2000
18	Let sleeping dogs lie? ⁵⁷	Ostrander EA...Giniger E	10471483	1999
19	Narcolepsy: a key role for hypocretins (orexins) ⁵⁷	Siegel JM	10481905	1999
20	Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. ⁵⁷	Chemelli RM...Yanagisawa M	10481909	1999
21	The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. ⁵⁷	Lin L...Mignot E	10458611	1999
22	Genetic studies in narcolepsy, a disorder affecting REM sleep. ⁵⁷	Faraco J...Mignot E	9987919	1999
23	Genetic and familial aspects of narcolepsy. ⁵⁷	Mignot E	9484418	1998
24	The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. ⁵⁷	de Lecea L...Sutcliffe JG	9419374	1998
25	HLA DQB1*0602 is associated with cataplexy in 509 narcoleptic patients. ⁵⁷	Mignot E...Guilleminault C	9456467	1997
26	Pharmacological aspects of human and canine narcolepsy. ⁵⁷	Nishino S...Mignot E	9185233	1997
27	Autonomic nervous system function in narcolepsy. ⁵⁷	Hublin C...Partinen M	10607117	1994
28	DQ (rather than DR) gene marks susceptibility to narcolepsy. ⁵⁷	Matsuki K...Mignot E	1349071	1992
29	Genetic linkage of autosomal recessive canine narcolepsy with a mu immunoglobulin heavy-chain switch-like segment. ⁵⁷	Mignot E...Grumet FC	1673032	1991
30	Genetic heterogeneity in narcolepsy. ⁵⁷	Singh SM...Jung JH	1969083	1990
31	Familial patterns of narcolepsy. ⁵⁷	Guilleminault C...Grumet FC	2574313	1989
32	Restriction fragment length polymorphism in canine narcolepsy. ⁵⁷	Motoyama M...McDevitt HO	2563354	1989
33	Narcolepsy-cataplexy in Israeli Jews is associated exclusively with the HLA DR2 haplotype. A study at the serological and genomic level. ⁵⁷	Wilner A...Brautbar C	2896649	1988
34	HLA and narcolepsy in a German population. ⁵⁷	Mueller-Eckhardt G...Mueller-Eckhardt C	3641479	1986
35	Human histocompatibility leukocyte antigen (HLA) haplotype frequencies estimated from the data on HLA class I, II, and III antigens in 111 Japanese narcoleptics. ⁵⁷	Matsuki K...Honda Y	3865934	1985
36	HLA antigens in Japanese patients with narcolepsy. All the patients were DR2 positive. ⁵⁷	Juji T...Doi Y	6597978	1984
37	Genetic markers in narcolepsy. ⁵⁷	Langdon N...Parkes D	6150235	1984
38	Canine model of narcolepsy: genetic and developmental determinants. ⁵⁷	Baker TL...Dement WC	7199479	1982
39	Genetic factors in canine narcolepsy. ⁵⁷	Foutz AS...Dement WC	574310	1979
40	Genetic study of narcoleptic syndrome. ⁵⁷	Baraitser M...Parkes JD	712757	1978
41	The inheritance of diurnal sleepiness as measured by pupillography. ⁵⁷	Yoss RE	5425102	1970
42	The pupillogram and narcolepsy. A method to measure decreased levels of wakefulness. ⁵⁷	Yoss RE...Ogle KN	5387594	1969
43	Hereditary cataplexy. ⁵⁷	Gelardi JM...Brown JW	6062995	1967
44	Excessive daytime sleepiness in cancer patients. ⁶¹	Jaumally BA...Faiz SA	32939599	2020
45	A comparative study of methods for automatic detection of rapid eye movement abnormal muscular activity in narcolepsy. ⁶¹	Olesen AN...Jennum P	29530376	2018
46	Prevalence of sleep disorders among ESRD patients. ⁶¹	Ezzat H...Mohab A	25959021	2015
47	Characteristics of REM sleep behavior disorder in childhood. ⁶¹	Lloyd R...Kotagal S	22505856	2012
48	Outcomes of CPAP treatment in a sleep laboratory specialized in neuropsychiatry. ⁶¹	Antczak J...Popp R	15611589	2004
49	Sleep disturbance in chronic fatigue syndrome. ⁶¹	Krupp LB...Mendelson WB	8510058	1993
50	The multiple sleep latency test in the diagnosis of sleep disorders. ⁶¹	Silber MH	2296743	1990

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Genes for Narcolepsy 1

Genes related to Narcolepsy 1 (9 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	HCRT	Hypocretin Neuropeptide Precursor	Protein Coding	1390.75	Molecular basis known ⁵⁷ Pathogenic ⁶ Causative variation ⁷² Genetic Tests ²⁹ Unconfirmed association ⁵⁷ Susceptibility factor ⁵⁸ GeneCards inferred via : Disorders Variants (show sections)	10973318 23643651
2	MOG	Myelin Oligodendrocyte Glycoprotein	Protein Coding	425	Pathogenic ⁶ Susceptibility factor ⁵⁸	21907016
3	NPC1	NPC Intracellular Cholesterol Transporter 1	Protein Coding	400	Pathogenic ⁶
4	CTSH	Cathepsin H	Protein Coding	25	Susceptibility factor ⁵⁸	23459209
5	HLA-DQB1	Major Histocompatibility Complex, Class II, DQ Beta 1	Protein Coding	25	Susceptibility factor ⁵⁸	18706091
6	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	25	Susceptibility factor ⁵⁸	18706091 19410508
7	P2RY11	Purinergic Receptor P2Y11	Protein Coding	25	Susceptibility factor ⁵⁸	24204295
8	TNFSF4	TNF Superfamily Member 4	Protein Coding	25	Susceptibility factor ⁵⁸	23459209
9	ZNF365	Zinc Finger Protein 365	Protein Coding	25	Susceptibility factor ⁵⁸	24204295

Sources

Variations for Narcolepsy 1

ClinVar genetic disease variations for Narcolepsy 1:

⁶

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	HCRT	NM_001524.1(HCRT):c.47T>G (p.Leu16Arg)	SNV	Pathogenic	7303	rs104894574	GRCh37: 17:40336521-40336521 GRCh38: 17:42184503-42184503
2	MOG	NM_206809.4(MOG):c.398C>G (p.Ser133Cys)	SNV	Pathogenic	29798	rs387906655	GRCh37: 6:29627405-29627405 GRCh38: 6:29659628-29659628
3	NPC1	NM_000271.5(NPC1):c.3019C>G (p.Pro1007Ala)	SNV	Pathogenic	2966	rs80358257	GRCh37: 18:21118528-21118528 GRCh38: 18:23538564-23538564
4	NPC1	NM_000271.5(NPC1):c.1421C>T (p.Pro474Leu)	SNV	Pathogenic	374049	rs372445155	GRCh37: 18:21134854-21134854 GRCh38: 18:23554890-23554890
5	MOG	NM_206809.4(MOG):c.88+18dup	Duplication	Benign	931819		GRCh37: 6:29625084-29625085 GRCh38: 6:29657307-29657308

UniProtKB/Swiss-Prot genetic disease variations for Narcolepsy 1:

⁷²

#	Symbol	AA change	Variation ID	SNP ID
1	HCRT	p.Leu16Arg	VAR_011633	rs104894574

Sources

Expression for Narcolepsy 1

Search GEO for disease gene expression data for Narcolepsy 1.

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Pathways for Narcolepsy 1

Pathways related to Narcolepsy 1 according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	G-protein signaling N-RAS regulation pathway ²³ Show member pathways Immune response Antigen presentation by MHC class II ²³	10.91	HLA-DRB1 HLA-DQB1
2	MHC class II antigen presentation ⁶⁵	10.81	HLA-DRB1 HLA-DQB1 CTSH

Sources

GO Terms for Narcolepsy 1

Cellular components related to Narcolepsy 1 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	lysosomal membrane	GO:0005765	9.54	NPC1 HLA-DRB1 HLA-DQB1
2	endocytic vesicle membrane	GO:0030666	9.43	HLA-DRB1 HLA-DQB1
3	ER to Golgi transport vesicle membrane	GO:0012507	9.4	HLA-DRB1 HLA-DQB1
4	transport vesicle membrane	GO:0030658	9.32	HLA-DRB1 HLA-DQB1
5	clathrin-coated endocytic vesicle membrane	GO:0030669	9.26	HLA-DRB1 HLA-DQB1
6	integral component of lumenal side of endoplasmic reticulum membrane	GO:0071556	9.16	HLA-DRB1 HLA-DQB1
7	MHC class II protein complex	GO:0042613	8.96	HLA-DRB1 HLA-DQB1
8	lysosome	GO:0005764	8.92	NPC1 HLA-DRB1 HLA-DQB1 CTSH

Biological processes related to Narcolepsy 1 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	T cell receptor signaling pathway	GO:0050852	9.54	HLA-DQB1 HLA-DRB1 MOG
2	phospholipase C-activating G protein-coupled receptor signaling pathway	GO:0007200	9.43	HCRT P2RY11
3	negative regulation of interferon-gamma production	GO:0032689	9.4	HLA-DRB1 TNFSF4
4	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	GO:0002504	9.32	HLA-DQB1 HLA-DRB1
5	positive regulation of memory T cell differentiation	GO:0043382	9.26	HLA-DRB1 TNFSF4
6	humoral immune response mediated by circulating immunoglobulin	GO:0002455	9.16	HLA-DQB1 HLA-DRB1
7	immunoglobulin production involved in immunoglobulin mediated immune response	GO:0002381	8.96	HLA-DQB1 HLA-DRB1
8	antigen processing and presentation	GO:0019882	8.8	CTSH HLA-DQB1 HLA-DRB1

Molecular functions related to Narcolepsy 1 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	peptide antigen binding	GO:0042605	8.96	HLA-DRB1 HLA-DQB1
2	MHC class II receptor activity	GO:0032395	8.62	HLA-DRB1 HLA-DQB1

Sources

Sources for Narcolepsy 1

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia

Narcolepsy 1 (NRCLP1)

Aliases & Classifications for Narcolepsy 1

MalaCards integrated aliases for Narcolepsy 1:

Characteristics:

Orphanet epidemiological data:

OMIM®:

HPO:

Classifications:

External Ids:

Summaries for Narcolepsy 1

Related Diseases for Narcolepsy 1

Diseases in the Narcolepsy family:

Diseases related to Narcolepsy 1 via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Narcolepsy 1:

Symptoms & Phenotypes for Narcolepsy 1

Human phenotypes related to Narcolepsy 1:

Symptoms via clinical synopsis from OMIM®:

Clinical features from OMIM®:

UMLS symptoms related to Narcolepsy 1:

Drugs & Therapeutics for Narcolepsy 1

Interventional clinical trials:

Genetic Tests for Narcolepsy 1

Genetic tests related to Narcolepsy 1:

Anatomical Context for Narcolepsy 1

MalaCards organs/tissues related to Narcolepsy 1:

Publications for Narcolepsy 1

Articles related to Narcolepsy 1:

Genes for Narcolepsy 1

Genes related to Narcolepsy 1 (9 elite genes):

Variations for Narcolepsy 1

ClinVar genetic disease variations for Narcolepsy 1:

UniProtKB/Swiss-Prot genetic disease variations for Narcolepsy 1:

Expression for Narcolepsy 1

Pathways for Narcolepsy 1

Pathways related to Narcolepsy 1 according to GeneCards Suite gene sharing:

GO Terms for Narcolepsy 1

Cellular components related to Narcolepsy 1 according to GeneCards Suite gene sharing:

Biological processes related to Narcolepsy 1 according to GeneCards Suite gene sharing:

Molecular functions related to Narcolepsy 1 according to GeneCards Suite gene sharing:

Sources for Narcolepsy 1