MCID: NRC010
MIFTS: 37

Narcolepsy 2

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Narcolepsy 2

MalaCards integrated aliases for Narcolepsy 2:

Name: Narcolepsy 2 57 13
Narcolepsy 2, Susceptibility to 57 29 73
Narcolepsy Without Cataplexy 59
Narcolepsy Type 2 59
Nrclp2 57

Characteristics:

Orphanet epidemiological data:

59
narcolepsy type 2
Prevalence: 1-5/10000 (United States); Age of onset: Adolescent,Adult,Childhood; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

OMIM 57 605841
Orphanet 59 ORPHA83465
ICD10 via Orphanet 34 G47.4
UMLS 73 C1853901

Summaries for Narcolepsy 2

MalaCards based summary : Narcolepsy 2, also known as narcolepsy 2, susceptibility to, is related to idiopathic hypersomnia and hypersomnia. An important gene associated with Narcolepsy 2 is NRCLP2 (Narcolepsy, HLA-Associated), and among its related pathways/superpathways are Phagosome and Cell adhesion molecules (CAMs). Affiliated tissues include tongue, and related phenotypes are hallucinations and insomnia

Description from OMIM: 605841

Related Diseases for Narcolepsy 2

Diseases in the Narcolepsy family:

Narcolepsy 1 Narcolepsy 2
Narcolepsy 3 Narcolepsy 4
Narcolepsy 5 Narcolepsy 6
Narcolepsy 7

Diseases related to Narcolepsy 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 idiopathic hypersomnia 30.6 HCRT HLA-DQB1
2 hypersomnia 30.2 HCRT HLA-DQB1 HLA-DRB1
3 narcolepsy 29.0 HCRT HLA-DQB1 HLA-DRB1 NRCLP2
4 idiopathic hypersomnia without long sleep time 10.3
5 recurrent hypersomnia 10.0 HCRT HLA-DQB1
6 kleine-levin hibernation syndrome 10.0 HCRT HLA-DQB1
7 guillain-barre syndrome 9.9 HCRT HLA-DQB1
8 limbic encephalitis with lgi1 antibodies 9.9 HLA-DQB1 HLA-DRB1
9 autoimmune polyglandular syndrome type 3 9.9 HLA-DQB1 HLA-DRB1
10 metal allergy 9.9 HLA-DQB1 HLA-DRB1
11 lichen planopilaris 9.9 HLA-DQB1 HLA-DRB1
12 type ii mixed cryoglobulinemia 9.9 HLA-DQB1 HLA-DRB1
13 beryllium disease 9.9 HLA-DQB1 HLA-DRB1
14 recurrent respiratory papillomatosis 9.9 HLA-DQB1 HLA-DRB1
15 chronic beryllium disease 9.9 HLA-DQB1 HLA-DRB1
16 lichen sclerosus 9.9 HLA-DQB1 HLA-DRB1
17 whipple disease 9.9 HLA-DQB1 HLA-DRB1
18 pityriasis rosea 9.9 HLA-DQB1 HLA-DRB1
19 pediatric multiple sclerosis 9.9 HLA-DQB1 HLA-DRB1
20 microscopic colitis 9.9 HLA-DQB1 HLA-DRB1
21 osteonecrosis of the jaw 9.9 HLA-DQB1 HLA-DRB1
22 idiopathic bronchiectasis 9.9 HLA-DQB1 HLA-DRB1
23 neuromyelitis optica 9.9 HCRT HLA-DRB1
24 peanut allergy 9.9 HLA-DQB1 HLA-DRB1
25 oligoarticular juvenile idiopathic arthritis 9.9 HLA-DQB1 HLA-DRB1
26 glaucomatocyclitic crisis 9.9 HLA-DQB1 HLA-DRB1
27 geographic tongue 9.9 HLA-DQB1 HLA-DRB1
28 panuveitis 9.9 HLA-DQB1 HLA-DRB1
29 ocular cicatricial pemphigoid 9.8 HLA-DQB1 HLA-DRB1
30 focal epithelial hyperplasia 9.8 HLA-DQB1 HLA-DRB1
31 paraneoplastic pemphigus 9.8 HLA-DQB1 HLA-DRB1
32 vogt-koyanagi-harada disease 9.8 HLA-DQB1 HLA-DRB1
33 rubella 9.8 HLA-DQB1 HLA-DRB1
34 graft-versus-host disease 9.8 HLA-DQB1 HLA-DRB1
35 autoimmune hepatitis 9.8 HLA-DQB1 HLA-DRB1
36 bullous pemphigoid 9.7 HLA-DQB1 HLA-DRB1
37 acute disseminated encephalomyelitis 9.7 HCRT HLA-DQB1 HLA-DRB1
38 leishmaniasis 9.6 HLA-DQB1 HLA-DRB1
39 narcolepsy 1 9.5 HCRT HLA-DQB1 HLA-DRB1 ZNF365

Graphical network of the top 20 diseases related to Narcolepsy 2:



Diseases related to Narcolepsy 2

Symptoms & Phenotypes for Narcolepsy 2

Clinical features from OMIM:

605841

Human phenotypes related to Narcolepsy 2:

59 32
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hallucinations 59 32 hallmark (90%) Very frequent (99-80%) HP:0000738
2 insomnia 59 32 hallmark (90%) Very frequent (99-80%) HP:0100785
3 excessive daytime somnolence 59 32 hallmark (90%) Very frequent (99-80%) HP:0001262
4 sleep disturbance 59 Very frequent (99-80%)
5 behavioral abnormality 59 Occasional (29-5%)

Drugs & Therapeutics for Narcolepsy 2

Search Clinical Trials , NIH Clinical Center for Narcolepsy 2

Genetic Tests for Narcolepsy 2

Genetic tests related to Narcolepsy 2:

# Genetic test Affiliating Genes
1 Narcolepsy 2, Susceptibility to 29

Anatomical Context for Narcolepsy 2

MalaCards organs/tissues related to Narcolepsy 2:

41
Tongue

Publications for Narcolepsy 2

Articles related to Narcolepsy 2:

# Title Authors Year
1
Decreased incidence of childhood narcolepsy 2 years after the 2009 H1N1 winter flu pandemic. ( 23225098 )
2012

Variations for Narcolepsy 2

Expression for Narcolepsy 2

Search GEO for disease gene expression data for Narcolepsy 2.

Pathways for Narcolepsy 2

GO Terms for Narcolepsy 2

Cellular components related to Narcolepsy 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 trans-Golgi network membrane GO:0032588 9.4 HLA-DQB1 HLA-DRB1
2 endocytic vesicle membrane GO:0030666 9.37 HLA-DQB1 HLA-DRB1
3 ER to Golgi transport vesicle membrane GO:0012507 9.32 HLA-DQB1 HLA-DRB1
4 transport vesicle membrane GO:0030658 9.26 HLA-DQB1 HLA-DRB1
5 clathrin-coated endocytic vesicle membrane GO:0030669 9.16 HLA-DQB1 HLA-DRB1
6 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DQB1 HLA-DRB1
7 MHC class II protein complex GO:0042613 8.62 HLA-DQB1 HLA-DRB1

Biological processes related to Narcolepsy 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell receptor signaling pathway GO:0050852 9.4 HLA-DQB1 HLA-DRB1
2 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.37 HLA-DQB1 HLA-DRB1
3 interferon-gamma-mediated signaling pathway GO:0060333 9.32 HLA-DQB1 HLA-DRB1
4 antigen processing and presentation GO:0019882 9.26 HLA-DQB1 HLA-DRB1
5 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.16 HLA-DQB1 HLA-DRB1
6 humoral immune response mediated by circulating immunoglobulin GO:0002455 8.96 HLA-DQB1 HLA-DRB1
7 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.62 HLA-DQB1 HLA-DRB1

Molecular functions related to Narcolepsy 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.96 HLA-DQB1 HLA-DRB1
2 MHC class II receptor activity GO:0032395 8.62 HLA-DQB1 HLA-DRB1

Sources for Narcolepsy 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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