Narcolepsy 2 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Narcolepsy 2

MalaCards integrated aliases for Narcolepsy 2:

Name: Narcolepsy 2 ⁵⁷ ¹³

Narcolepsy 2, Susceptibility to ⁵⁷ ²⁹ ⁷³

Narcolepsy Without Cataplexy ⁵⁹

Narcolepsy Type 2 ⁵⁹

Nrclp2 ⁵⁷

Characteristics:

Orphanet epidemiological data:

⁵⁹

narcolepsy type 2
Prevalence: 1-5/10000 (United States); Age of onset: Adolescent,Adult,Childhood; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases
Anatomical: Neuronal diseases Mental diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the nervous system

Episodic and paroxysmal disorders

Sleep disorders

Narcolepsy and cataplexy

Orphanet: ⁵⁹

Rare neurological diseases

External Ids:

OMIM ⁵⁷ 605841

Orphanet ⁵⁹ ORPHA83465

ICD10 via Orphanet ³⁴ G47.4

SNOMED-CT via HPO ⁶⁹ 7011001 271782001 79519003 more

UMLS ⁷³ C1853901

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Summaries for Narcolepsy 2

MalaCards based summary : Narcolepsy 2, also known as narcolepsy 2, susceptibility to, is related to idiopathic hypersomnia and hypersomnia. An important gene associated with Narcolepsy 2 is NRCLP2 (Narcolepsy, HLA-Associated), and among its related pathways/superpathways are Phagosome and Cell adhesion molecules (CAMs). Affiliated tissues include tongue, and related phenotypes are hallucinations and insomnia

Description from OMIM: 605841

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Related Diseases for Narcolepsy 2

Diseases in the Narcolepsy family:

Narcolepsy 1	Narcolepsy 2
Narcolepsy 3	Narcolepsy 4
Narcolepsy 5	Narcolepsy 6
Narcolepsy 7

Diseases related to Narcolepsy 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)

#	Related Disease	Score	Top Affiliating Genes
1	idiopathic hypersomnia	30.6	HCRT HLA-DQB1
2	hypersomnia	30.2	HCRT HLA-DQB1 HLA-DRB1
3	narcolepsy	29.0	HCRT HLA-DQB1 HLA-DRB1 NRCLP2
4	idiopathic hypersomnia without long sleep time	10.3
5	recurrent hypersomnia	10.0	HCRT HLA-DQB1
6	kleine-levin hibernation syndrome	10.0	HCRT HLA-DQB1
7	guillain-barre syndrome	9.9	HCRT HLA-DQB1
8	limbic encephalitis with lgi1 antibodies	9.9	HLA-DQB1 HLA-DRB1
9	autoimmune polyglandular syndrome type 3	9.9	HLA-DQB1 HLA-DRB1
10	metal allergy	9.9	HLA-DQB1 HLA-DRB1
11	lichen planopilaris	9.9	HLA-DQB1 HLA-DRB1
12	type ii mixed cryoglobulinemia	9.9	HLA-DQB1 HLA-DRB1
13	beryllium disease	9.9	HLA-DQB1 HLA-DRB1
14	recurrent respiratory papillomatosis	9.9	HLA-DQB1 HLA-DRB1
15	chronic beryllium disease	9.9	HLA-DQB1 HLA-DRB1
16	lichen sclerosus	9.9	HLA-DQB1 HLA-DRB1
17	whipple disease	9.9	HLA-DQB1 HLA-DRB1
18	pityriasis rosea	9.9	HLA-DQB1 HLA-DRB1
19	pediatric multiple sclerosis	9.9	HLA-DQB1 HLA-DRB1
20	microscopic colitis	9.9	HLA-DQB1 HLA-DRB1
21	osteonecrosis of the jaw	9.9	HLA-DQB1 HLA-DRB1
22	idiopathic bronchiectasis	9.9	HLA-DQB1 HLA-DRB1
23	neuromyelitis optica	9.9	HCRT HLA-DRB1
24	peanut allergy	9.9	HLA-DQB1 HLA-DRB1
25	oligoarticular juvenile idiopathic arthritis	9.9	HLA-DQB1 HLA-DRB1
26	glaucomatocyclitic crisis	9.9	HLA-DQB1 HLA-DRB1
27	geographic tongue	9.9	HLA-DQB1 HLA-DRB1
28	panuveitis	9.9	HLA-DQB1 HLA-DRB1
29	ocular cicatricial pemphigoid	9.8	HLA-DQB1 HLA-DRB1
30	focal epithelial hyperplasia	9.8	HLA-DQB1 HLA-DRB1
31	paraneoplastic pemphigus	9.8	HLA-DQB1 HLA-DRB1
32	vogt-koyanagi-harada disease	9.8	HLA-DQB1 HLA-DRB1
33	rubella	9.8	HLA-DQB1 HLA-DRB1
34	graft-versus-host disease	9.8	HLA-DQB1 HLA-DRB1
35	autoimmune hepatitis	9.8	HLA-DQB1 HLA-DRB1
36	bullous pemphigoid	9.7	HLA-DQB1 HLA-DRB1
37	acute disseminated encephalomyelitis	9.7	HCRT HLA-DQB1 HLA-DRB1
38	leishmaniasis	9.6	HLA-DQB1 HLA-DRB1
39	narcolepsy 1	9.5	HCRT HLA-DQB1 HLA-DRB1 ZNF365

Graphical network of the top 20 diseases related to Narcolepsy 2:

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Symptoms & Phenotypes for Narcolepsy 2

Clinical features from OMIM:

605841

Human phenotypes related to Narcolepsy 2:

⁵⁹ ³²

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	hallucinations ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0000738
2	insomnia ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0100785
3	excessive daytime somnolence ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0001262
4	sleep disturbance ⁵⁹		Very frequent (99-80%)
5	behavioral abnormality ⁵⁹		Occasional (29-5%)

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Drugs & Therapeutics for Narcolepsy 2

Search Clinical Trials , NIH Clinical Center for Narcolepsy 2

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Genetic Tests for Narcolepsy 2

Genetic tests related to Narcolepsy 2:

#	Genetic test	Affiliating Genes
1	Narcolepsy 2, Susceptibility to ²⁹

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Anatomical Context for Narcolepsy 2

MalaCards organs/tissues related to Narcolepsy 2:

⁴¹

Tongue

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Publications for Narcolepsy 2

Articles related to Narcolepsy 2:

#	Title	Authors	Year
1	Decreased incidence of childhood narcolepsy 2 years after the 2009 H1N1 winter flu pandemic. ( 23225098 )		2012

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Genes for Narcolepsy 2

Genes related to Narcolepsy 2 (5 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NRCLP2	Narcolepsy, HLA-Associated	Genetic Locus	50	Genetic linkage ⁵⁷
2	ZNF365	Zinc Finger Protein 365	Protein Coding	25	Susceptibility factor ⁵⁹
3	HLA-DQB1	Major Histocompatibility Complex, Class II, DQ Beta 1	Protein Coding	25	Susceptibility factor ⁵⁹
4	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	25	Susceptibility factor ⁵⁹
5	HCRT	Hypocretin Neuropeptide Precursor	Protein Coding	25	Candidate gene tested ⁵⁹

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Variations for Narcolepsy 2

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Expression for Narcolepsy 2

Search GEO for disease gene expression data for Narcolepsy 2.

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Pathways for Narcolepsy 2

Pathways related to Narcolepsy 2 according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Phagosome ³⁷	11.64	HLA-DQB1 HLA-DRB1
2	Cell adhesion molecules (CAMs) ³⁷	11.56	HLA-DQB1 HLA-DRB1
3	S-1P Stimulated Signaling ⁶⁴	11.42	HLA-DQB1 HLA-DRB1
4	Translocation of ZAP-70 to Immunological synapse ⁶⁶ Show member pathways Generation of second messenger molecules ⁶⁶ PD-1 signaling ⁶⁶ Phosphorylation of CD3 and TCR zeta chains ⁶⁶	11.41	HLA-DQB1 HLA-DRB1
5	MHC class II antigen presentation ⁶⁶	11.33	HLA-DQB1 HLA-DRB1
6	Hematopoietic cell lineage ³⁷	11.24	HLA-DQB1 HLA-DRB1
7	Rheumatoid arthritis ³⁷	11.11	HLA-DQB1 HLA-DRB1
8	CTLA4 Signaling ⁶⁴	10.81	HLA-DQB1 HLA-DRB1
9	Staphylococcus aureus infection ³⁷	10.37	HLA-DQB1 HLA-DRB1

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GO Terms for Narcolepsy 2

Cellular components related to Narcolepsy 2 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	trans-Golgi network membrane	GO:0032588	9.4	HLA-DQB1 HLA-DRB1
2	endocytic vesicle membrane	GO:0030666	9.37	HLA-DQB1 HLA-DRB1
3	ER to Golgi transport vesicle membrane	GO:0012507	9.32	HLA-DQB1 HLA-DRB1
4	transport vesicle membrane	GO:0030658	9.26	HLA-DQB1 HLA-DRB1
5	clathrin-coated endocytic vesicle membrane	GO:0030669	9.16	HLA-DQB1 HLA-DRB1
6	integral component of lumenal side of endoplasmic reticulum membrane	GO:0071556	8.96	HLA-DQB1 HLA-DRB1
7	MHC class II protein complex	GO:0042613	8.62	HLA-DQB1 HLA-DRB1

Biological processes related to Narcolepsy 2 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	T cell receptor signaling pathway	GO:0050852	9.4	HLA-DQB1 HLA-DRB1
2	antigen processing and presentation of exogenous peptide antigen via MHC class II	GO:0019886	9.37	HLA-DQB1 HLA-DRB1
3	interferon-gamma-mediated signaling pathway	GO:0060333	9.32	HLA-DQB1 HLA-DRB1
4	antigen processing and presentation	GO:0019882	9.26	HLA-DQB1 HLA-DRB1
5	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	GO:0002504	9.16	HLA-DQB1 HLA-DRB1
6	humoral immune response mediated by circulating immunoglobulin	GO:0002455	8.96	HLA-DQB1 HLA-DRB1
7	immunoglobulin production involved in immunoglobulin mediated immune response	GO:0002381	8.62	HLA-DQB1 HLA-DRB1

Molecular functions related to Narcolepsy 2 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	peptide antigen binding	GO:0042605	8.96	HLA-DQB1 HLA-DRB1
2	MHC class II receptor activity	GO:0032395	8.62	HLA-DQB1 HLA-DRB1

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Sources for Narcolepsy 2

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

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⁸ Cochrane Library

⁹ Cosmic

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²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

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⁴⁴ MeSH

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⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

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⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

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⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia