MCID: NRC010
MIFTS: 36

Narcolepsy 2

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Narcolepsy 2

MalaCards integrated aliases for Narcolepsy 2:

Name: Narcolepsy 2 58 13
Narcolepsy 2, Susceptibility to 58 30 74
Narcolepsy Without Cataplexy 60 17
Narcolepsy Type 2 60
Nrclp2 58

Characteristics:

Orphanet epidemiological data:

60
narcolepsy type 2
Prevalence: 1-5/10000 (United States); Age of onset: Adolescent,Adult,Childhood; Age of death: normal life expectancy;

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

OMIM 58 605841
ICD10 via Orphanet 35 G47.4
Orphanet 60 ORPHA83465
UMLS 74 C1853901

Summaries for Narcolepsy 2

MalaCards based summary : Narcolepsy 2, also known as narcolepsy 2, susceptibility to, is related to idiopathic hypersomnia and hypersomnia. An important gene associated with Narcolepsy 2 is NRCLP2 (Narcolepsy, HLA-Associated), and among its related pathways/superpathways are Phagosome and Cell adhesion molecules (CAMs). Affiliated tissues include testes, and related phenotypes are hallucinations and insomnia

Description from OMIM: 605841

Related Diseases for Narcolepsy 2

Diseases in the Narcolepsy family:

Narcolepsy 1 Narcolepsy 2
Narcolepsy 3 Narcolepsy 4
Narcolepsy 5 Narcolepsy 6
Narcolepsy 7

Diseases related to Narcolepsy 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 idiopathic hypersomnia 30.7 HCRT HLA-DQB1
2 hypersomnia 30.0 HCRT HLA-DQB1 HLA-DRB1
3 narcolepsy 28.7 HCRT HLA-DQB1 HLA-DRB1 NRCLP2
4 recurrent hypersomnia 10.0 HCRT HLA-DQB1
5 kleine-levin hibernation syndrome 9.9 HCRT HLA-DQB1
6 guillain-barre syndrome 9.9 HCRT HLA-DQB1
7 limbic encephalitis with lgi1 antibodies 9.9 HLA-DQB1 HLA-DRB1
8 autoimmune polyglandular syndrome type 3 9.8 HLA-DQB1 HLA-DRB1
9 metal allergy 9.8 HLA-DQB1 HLA-DRB1
10 lichen planopilaris 9.8 HLA-DQB1 HLA-DRB1
11 type ii mixed cryoglobulinemia 9.8 HLA-DQB1 HLA-DRB1
12 beryllium disease 9.8 HLA-DQB1 HLA-DRB1
13 recurrent respiratory papillomatosis 9.8 HLA-DQB1 HLA-DRB1
14 chronic beryllium disease 9.8 HLA-DQB1 HLA-DRB1
15 lichen sclerosus 9.8 HLA-DQB1 HLA-DRB1
16 whipple disease 9.8 HLA-DQB1 HLA-DRB1
17 pityriasis rosea 9.8 HLA-DQB1 HLA-DRB1
18 pediatric multiple sclerosis 9.8 HLA-DQB1 HLA-DRB1
19 microscopic colitis 9.8 HLA-DQB1 HLA-DRB1
20 osteonecrosis of the jaw 9.8 HLA-DQB1 HLA-DRB1
21 idiopathic bronchiectasis 9.8 HLA-DQB1 HLA-DRB1
22 neuromyelitis optica 9.8 HCRT HLA-DRB1
23 peanut allergy 9.8 HLA-DQB1 HLA-DRB1
24 pure red-cell aplasia 9.8 HLA-DQB1 HLA-DRB1
25 oligoarticular juvenile idiopathic arthritis 9.8 HLA-DQB1 HLA-DRB1
26 glaucomatocyclitic crisis 9.8 HLA-DQB1 HLA-DRB1
27 geographic tongue 9.8 HLA-DQB1 HLA-DRB1
28 panuveitis 9.8 HLA-DQB1 HLA-DRB1
29 ocular cicatricial pemphigoid 9.8 HLA-DQB1 HLA-DRB1
30 focal epithelial hyperplasia 9.8 HLA-DQB1 HLA-DRB1
31 paraneoplastic pemphigus 9.7 HLA-DQB1 HLA-DRB1
32 vogt-koyanagi-harada disease 9.7 HLA-DQB1 HLA-DRB1
33 rubella 9.7 HLA-DQB1 HLA-DRB1
34 graft-versus-host disease 9.7 HLA-DQB1 HLA-DRB1
35 autoimmune hepatitis 9.7 HLA-DQB1 HLA-DRB1
36 bullous pemphigoid 9.6 HLA-DQB1 HLA-DRB1
37 leishmaniasis 9.6 HLA-DQB1 HLA-DRB1
38 acute disseminated encephalomyelitis 9.6 HCRT HLA-DQB1 HLA-DRB1
39 diabetes mellitus, insulin-dependent 9.4 HLA-DQB1 HLA-DRB1
40 narcolepsy 1 9.3 HCRT HLA-DQB1 HLA-DRB1 ZNF365

Graphical network of the top 20 diseases related to Narcolepsy 2:



Diseases related to Narcolepsy 2

Symptoms & Phenotypes for Narcolepsy 2

Human phenotypes related to Narcolepsy 2:

60 33
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hallucinations 60 33 hallmark (90%) Very frequent (99-80%) HP:0000738
2 insomnia 60 33 hallmark (90%) Very frequent (99-80%) HP:0100785
3 excessive daytime somnolence 60 33 hallmark (90%) Very frequent (99-80%) HP:0001262
4 sleep disturbance 60 Very frequent (99-80%)
5 behavioral abnormality 60 Occasional (29-5%)

Clinical features from OMIM:

605841

Drugs & Therapeutics for Narcolepsy 2

Search Clinical Trials , NIH Clinical Center for Narcolepsy 2

Genetic Tests for Narcolepsy 2

Genetic tests related to Narcolepsy 2:

# Genetic test Affiliating Genes
1 Narcolepsy 2, Susceptibility to 30

Anatomical Context for Narcolepsy 2

MalaCards organs/tissues related to Narcolepsy 2:

42
Testes

Publications for Narcolepsy 2

Articles related to Narcolepsy 2:

(show all 12)
# Title Authors Year
1
An association analysis of HLA-DQB1 with narcolepsy without cataplexy and idiopathic hypersomnia with/without long sleep time in a Japanese population. ( 27081540 )
2015
2
Oral L-carnitine as treatment for narcolepsy without cataplexy during pregnancy: a case report. ( 25475151 )
2015
3
Levothyroxine Improves Subjective Sleepiness in a Euthyroid Patient With Narcolepsy without Cataplexy. ( 25325591 )
2014
4
Challenges in diagnosing narcolepsy without cataplexy: a consensus statement. ( 24882898 )
2014
5
Test-retest reliability of the multiple sleep latency test in narcolepsy without cataplexy and idiopathic hypersomnia. ( 23946709 )
2013
6
Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy. ( 22942503 )
2012
7
Quality of life in patients with narcolepsy with cataplexy, narcolepsy without cataplexy, and idiopathic hypersomnia without long sleep time: comparison between patients on psychostimulants, drug-naA^ve patients and the general Japanese population. ( 22137109 )
2012
8
Decreased incidence of childhood narcolepsy 2 years after the 2009 H1N1 winter flu pandemic. ( 23225098 )
2012
9
Obesity accompanies narcolepsy with cataplexy but not narcolepsy without cataplexy. ( 21173745 )
2010
10
Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy. ( 19725250 )
2009
11
Health-related quality of life among drug-naA^ve patients with narcolepsy with cataplexy, narcolepsy without cataplexy, and idiopathic hypersomnia without long sleep time. ( 19110887 )
2008
12
Narcolepsy without cataplexy: 2 subtypes based on CSF hypocretin-1/orexin-A findings. ( 17162990 )
2006

Variations for Narcolepsy 2

Expression for Narcolepsy 2

Search GEO for disease gene expression data for Narcolepsy 2.

Pathways for Narcolepsy 2

GO Terms for Narcolepsy 2

Cellular components related to Narcolepsy 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 trans-Golgi network membrane GO:0032588 9.4 HLA-DQB1 HLA-DRB1
2 endocytic vesicle membrane GO:0030666 9.37 HLA-DQB1 HLA-DRB1
3 ER to Golgi transport vesicle membrane GO:0012507 9.32 HLA-DQB1 HLA-DRB1
4 transport vesicle membrane GO:0030658 9.26 HLA-DQB1 HLA-DRB1
5 clathrin-coated endocytic vesicle membrane GO:0030669 9.16 HLA-DQB1 HLA-DRB1
6 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DQB1 HLA-DRB1
7 MHC class II protein complex GO:0042613 8.62 HLA-DQB1 HLA-DRB1

Biological processes related to Narcolepsy 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell receptor signaling pathway GO:0050852 9.4 HLA-DQB1 HLA-DRB1
2 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.37 HLA-DQB1 HLA-DRB1
3 interferon-gamma-mediated signaling pathway GO:0060333 9.32 HLA-DQB1 HLA-DRB1
4 antigen processing and presentation GO:0019882 9.26 HLA-DQB1 HLA-DRB1
5 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.16 HLA-DQB1 HLA-DRB1
6 humoral immune response mediated by circulating immunoglobulin GO:0002455 8.96 HLA-DQB1 HLA-DRB1
7 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.62 HLA-DQB1 HLA-DRB1

Molecular functions related to Narcolepsy 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.96 HLA-DQB1 HLA-DRB1
2 MHC class II receptor activity GO:0032395 8.62 HLA-DQB1 HLA-DRB1

Sources for Narcolepsy 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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