MCID: NRC011
MIFTS: 17

Narcolepsy 3

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Narcolepsy 3

MalaCards integrated aliases for Narcolepsy 3:

Name: Narcolepsy 3 58 30 13 74
Nrclp3 58

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant

Miscellaneous:
genetic heterogeneity (see )
milder cases have isolated recurrent daytime sleepiness and/or lapses into sleep without cataplexy
variable age of onset (childhood to adulthood)


HPO:

33
narcolepsy 3:
Inheritance heterogeneous autosomal dominant inheritance


Classifications:



External Ids:

OMIM 58 609039
MedGen 43 C1836907
UMLS 74 C1836907

Summaries for Narcolepsy 3

MalaCards based summary : Narcolepsy 3, also known as nrclp3, is related to narcolepsy, and has symptoms including excessive daytime somnolence and hallucinations, hypnagogic. An important gene associated with Narcolepsy 3 is NRCLP3 (Narcolepsy 3). Affiliated tissues include eye, and related phenotypes are abnormal rapid eye movement sleep and excessive daytime sleepiness

Description from OMIM: 609039

Related Diseases for Narcolepsy 3

Diseases in the Narcolepsy family:

Narcolepsy 1 Narcolepsy 2
Narcolepsy 3 Narcolepsy 4
Narcolepsy 5 Narcolepsy 6
Narcolepsy 7

Diseases related to Narcolepsy 3 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 narcolepsy 11.4

Symptoms & Phenotypes for Narcolepsy 3

Human phenotypes related to Narcolepsy 3:

33 (show all 6)
# Description HPO Frequency HPO Source Accession
1 abnormal rapid eye movement sleep 33 HP:0002494
2 excessive daytime sleepiness 33 HP:0002189
3 cataplexy 33 HP:0002524
4 narcolepsy 33 HP:0030050
5 hypnagogic hallucinations 33 HP:0002519
6 paroxysmal drowsiness 33 HP:0002330

Symptoms via clinical synopsis from OMIM:

58
Neurologic Central Nervous System:
excessive daytime sleepiness
cataplexy, paroxysmal weakness or paralysis
cataplexy often triggered by strong emotions
attacks of disabling daytime drowsiness and low alertness
abnormal rapid eye movement (rem) sleep
more

Clinical features from OMIM:

609039

UMLS symptoms related to Narcolepsy 3:


excessive daytime somnolence, hallucinations, hypnagogic

Drugs & Therapeutics for Narcolepsy 3

Search Clinical Trials , NIH Clinical Center for Narcolepsy 3

Genetic Tests for Narcolepsy 3

Genetic tests related to Narcolepsy 3:

# Genetic test Affiliating Genes
1 Narcolepsy 3 30

Anatomical Context for Narcolepsy 3

MalaCards organs/tissues related to Narcolepsy 3:

42
Eye

Publications for Narcolepsy 3

Variations for Narcolepsy 3

Expression for Narcolepsy 3

Search GEO for disease gene expression data for Narcolepsy 3.

Pathways for Narcolepsy 3

GO Terms for Narcolepsy 3

Sources for Narcolepsy 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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