MCID: NRC013
MIFTS: 22

Narcolepsy 5

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Narcolepsy 5

MalaCards integrated aliases for Narcolepsy 5:

Name: Narcolepsy 5 57 13
Narcolepsy 5, Susceptibility to 57 29 73
Nrclp5 57

Classifications:



External Ids:

OMIM 57 612851
UMLS 73 C2748508

Summaries for Narcolepsy 5

MalaCards based summary : Narcolepsy 5, also known as narcolepsy 5, susceptibility to, is related to narcolepsy and borderline personality disorder. An important gene associated with Narcolepsy 5 is NRCLP5 (Narcolepsy 5), and among its related pathways/superpathways are Monoamine GPCRs and Serotonergic synapse.

Description from OMIM: 612851

Related Diseases for Narcolepsy 5

Diseases in the Narcolepsy family:

Narcolepsy 1 Narcolepsy 2
Narcolepsy 3 Narcolepsy 4
Narcolepsy 5 Narcolepsy 6
Narcolepsy 7

Diseases related to Narcolepsy 5 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 narcolepsy 11.2
2 borderline personality disorder 9.9 HTR1B HTR2A
3 personality disorder 9.9 HTR1B HTR2A
4 bulimia nervosa 9.9 HTR1B HTR2A
5 mood disorder 9.8 HTR1B HTR2A
6 obsessive-compulsive disorder 9.8 HTR1B HTR2A
7 migraine with or without aura 1 9.8 HTR1B HTR2A
8 alcohol dependence 9.8 HTR1B HTR2A
9 major depressive disorder 9.8 HTR1B HTR2A
10 attention deficit-hyperactivity disorder 9.7 HTR1B HTR2A

Graphical network of the top 20 diseases related to Narcolepsy 5:



Diseases related to Narcolepsy 5

Symptoms & Phenotypes for Narcolepsy 5

Clinical features from OMIM:

612851

Drugs & Therapeutics for Narcolepsy 5

Search Clinical Trials , NIH Clinical Center for Narcolepsy 5

Genetic Tests for Narcolepsy 5

Genetic tests related to Narcolepsy 5:

# Genetic test Affiliating Genes
1 Narcolepsy 5, Susceptibility to 29

Anatomical Context for Narcolepsy 5

Publications for Narcolepsy 5

Variations for Narcolepsy 5

Expression for Narcolepsy 5

Search GEO for disease gene expression data for Narcolepsy 5.

Pathways for Narcolepsy 5

GO Terms for Narcolepsy 5

Cellular components related to Narcolepsy 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 8.96 HTR1B HTR2A
2 integral component of presynaptic membrane GO:0099056 8.62 HTR1B HTR2A

Biological processes related to Narcolepsy 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.43 HTR1B HTR2A
2 chemical synaptic transmission GO:0007268 9.4 HTR1B HTR2A
3 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.37 HTR1B HTR2A
4 regulation of synaptic vesicle exocytosis GO:2000300 9.32 HTR1B HTR2A
5 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.26 HTR1B HTR2A
6 regulation of dopamine secretion GO:0014059 9.16 HTR1B HTR2A
7 behavior GO:0007610 8.96 HTR1B HTR2A
8 negative regulation of synaptic transmission, glutamatergic GO:0051967 8.62 HTR1B HTR2A

Molecular functions related to Narcolepsy 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 9.26 HTR1B HTR2A
2 neurotransmitter receptor activity GO:0030594 9.16 HTR1B HTR2A
3 G protein-coupled serotonin receptor activity GO:0004993 8.96 HTR1B HTR2A
4 serotonin binding GO:0051378 8.62 HTR1B HTR2A

Sources for Narcolepsy 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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