MCID: NSL003
MIFTS: 37

Nasal Cavity Adenocarcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Nasal Cavity Adenocarcinoma

MalaCards integrated aliases for Nasal Cavity Adenocarcinoma:

Name: Nasal Cavity Adenocarcinoma 12 15
Adenocarcinoma of Nasal Cavity 12 73
Adenocarcinoma of the Nasal Cavity 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4930
NCIt 50 C6015
UMLS 73 C1334920

Summaries for Nasal Cavity Adenocarcinoma

Disease Ontology : 12 A nasal cavity carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Nasal Cavity Adenocarcinoma, also known as adenocarcinoma of nasal cavity, is related to adenocarcinoma and bile reflux, and has symptoms including pain and rhinorrhea. An important gene associated with Nasal Cavity Adenocarcinoma is CXCL11 (C-X-C Motif Chemokine Ligand 11), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Menthol and Cisplatin have been mentioned in the context of this disorder. Related phenotypes are homeostasis/metabolism and digestive/alimentary

Related Diseases for Nasal Cavity Adenocarcinoma

Diseases related to Nasal Cavity Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 191)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 28.0 CDKN2A HRAS KRAS TP53
2 bile reflux 10.7 CCK CDX2
3 ovary neuroendocrine neoplasm 10.7 CDX2 KRT7
4 vaginal benign neoplasm 10.7 CDX2 KRT7
5 appendix adenocarcinoma 10.7 CDX2 KRT7
6 vaginal adenoma 10.7 CDX2 KRT7
7 vaginal tubulovillous adenoma 10.7 CDX2 KRT7
8 mucinous adenofibroma 10.6 CDX2 KRT7
9 anus adenocarcinoma 10.6 CDX2 KRT7
10 glandular cystitis 10.6 CDX2 KRT7
11 epithelial predominant wilms' tumor 10.6 CDX2 KRT7
12 opioid abuse 10.6 CCK PDYN
13 ovarian mucinous adenocarcinoma 10.6 CDX2 KRT7
14 thymus adenocarcinoma 10.6 CDX2 KRT7
15 gastric diffuse adenocarcinoma 10.6 CDX2 KRT7
16 jejunal adenocarcinoma 10.6 CDX2 KRT7
17 chronic cystitis 10.6 CDX2 KRT7
18 rectum adenocarcinoma 10.5 CDX2 KRT7
19 inverted transitional papilloma 10.5 CDKN2A KRT7
20 endocervical carcinoma 10.5 CDKN2A KRT7
21 vulval paget's disease 10.5 CDKN2A KRT7
22 adenoid basal cell carcinoma 10.5 CDKN2A KRT7
23 ampulla of vater adenocarcinoma 10.5 CDX2 KRT7
24 postcholecystectomy syndrome 10.5 CCK GAST
25 ovarian mucinous neoplasm 10.4 CDX2 KRT7
26 well-differentiated liposarcoma 10.4 CDKN2A KRT7
27 villous adenoma 10.4 CDX2 KRAS
28 nasal cavity cancer 10.4 CXCL11 KRT7 PDYN
29 duodenogastric reflux 10.4 CCK GAST
30 horseshoe kidney 10.3 CDX2 KRT7
31 malignant spiradenoma 10.3 KRT7 TP53
32 pancreatic cholera 10.3 CCK GAST
33 microinvasive gastric cancer 10.3 CDX2 GAST
34 female reproductive endometrioid cancer 10.3 KRT7 TP53
35 eccrine sweat gland neoplasm 10.3 KRT7 TP53
36 brain stem astrocytic neoplasm 10.3 CDKN2A TP53
37 papillary serous adenocarcinoma 10.3 KRT7 TP53
38 spiradenoma 10.3 KRT7 TP53
39 duodenal gastrinoma 10.3 CCK GAST
40 keratinizing squamous cell carcinoma 10.2 CDKN2A TP53
41 bartholin's gland benign neoplasm 10.2 CDKN2A TP53
42 vulva squamous cell carcinoma 10.2 CDKN2A TP53
43 thyroid lymphoma 10.2 CDKN2A TP53
44 nasal cavity squamous cell carcinoma 10.2 CDKN2A CXCL11 KRT7
45 rare adenocarcinoma of the breast 10.2 KRAS TP53
46 bone squamous cell carcinoma 10.2 CDKN2A TP53
47 scrotal carcinoma 10.2 CDKN2A TP53
48 anal squamous cell carcinoma 10.2 CDKN2A TP53
49 hyperplastic polyposis syndrome 10.2 KRAS TP53
50 gastric adenosquamous carcinoma 10.2 CDKN2A TP53

Graphical network of the top 20 diseases related to Nasal Cavity Adenocarcinoma:



Diseases related to Nasal Cavity Adenocarcinoma

Symptoms & Phenotypes for Nasal Cavity Adenocarcinoma

UMLS symptoms related to Nasal Cavity Adenocarcinoma:


pain, rhinorrhea

MGI Mouse Phenotypes related to Nasal Cavity Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.97 KRAS CCK KRT7 CDKN2A PDYN CDX2
2 digestive/alimentary MP:0005381 9.95 KRAS CDKN2A PDYN CDX2 TP53 GAST
3 endocrine/exocrine gland MP:0005379 9.91 HRAS KRAS CCK CDKN2A CDX2 TP53
4 neoplasm MP:0002006 9.73 KRAS CDKN2A CDX2 TP53 GAST HRAS
5 no phenotypic analysis MP:0003012 9.63 KRAS CCK CDKN2A PDYN TP53 HRAS
6 renal/urinary system MP:0005367 9.35 HRAS CCK KRAS KRT7 TP53
7 skeleton MP:0005390 9.1 HRAS KRAS CDKN2A PDYN CDX2 TP53

Drugs & Therapeutics for Nasal Cavity Adenocarcinoma

Drugs for Nasal Cavity Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Menthol Approved Phase 2 2216-51-5 16666
2
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
3
nivolumab Approved Phase 2 946414-94-4
4 Antibodies Phase 2
5 Immunoglobulins Phase 2
6 Antibodies, Monoclonal Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Clinical Trial of Endoscopic Surgery Followed by Chemotherapy and Proton Radiation for the Treatment of Tumors in the Sinus and Nasal Passages Recruiting NCT03274414 Phase 2 Cisplatin
2 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2

Search NIH Clinical Center for Nasal Cavity Adenocarcinoma

Genetic Tests for Nasal Cavity Adenocarcinoma

Anatomical Context for Nasal Cavity Adenocarcinoma

Publications for Nasal Cavity Adenocarcinoma

Articles related to Nasal Cavity Adenocarcinoma:

# Title Authors Year
1
TP53, p14ARF, p16INK4a and H-ras gene molecular analysis in intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses. ( 12673679 )
2003
2
K-ras-2 and p53 genotyping of intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses. ( 8685214 )
1996

Variations for Nasal Cavity Adenocarcinoma

Expression for Nasal Cavity Adenocarcinoma

Search GEO for disease gene expression data for Nasal Cavity Adenocarcinoma.

Pathways for Nasal Cavity Adenocarcinoma

Pathways related to Nasal Cavity Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.7 CDKN2A HRAS KRAS TP53
2 12.66 CDKN2A HRAS KRAS TP53
3
Show member pathways
12.63 CDKN2A HRAS KRAS TP53
4
Show member pathways
12.55 CDKN2A HRAS KRAS TP53
5
Show member pathways
12.39 CDKN2A CDX2 HRAS KRAS TP53
6 12.27 CDKN2A HRAS KRAS TP53
7
Show member pathways
12.18 CCK GAST HRAS KRAS
8 12.16 CDKN2A HRAS KRAS TP53
9 12.14 HRAS KRAS TP53
10
Show member pathways
12.02 HRAS KRAS TP53
11 12.01 HRAS KRAS TP53
12
Show member pathways
12 HRAS KRAS TP53
13 11.97 CDKN2A HRAS KRAS TP53
14
Show member pathways
11.96 HRAS KRAS TP53
15
Show member pathways
11.95 HRAS KRAS TP53
16 11.87 HRAS KRAS TP53
17 11.82 HRAS KRAS TP53
18 11.79 HRAS KRAS TP53
19 11.76 CDKN2A HRAS KRAS TP53
20 11.74 CDKN2A HRAS TP53
21 11.52 CDKN2A HRAS KRAS TP53
22 11.42 HRAS KRAS TP53
23 11.39 HRAS KRAS TP53
24 11.3 CDKN2A HRAS KRAS TP53
25 11.21 HRAS KRAS
26 11.18 CDKN2A TP53
27 11.15 HRAS KRAS
28 11.14 HRAS KRAS
29
Show member pathways
11.12 HRAS KRAS
30 11.12 HRAS KRAS TP53
31
Show member pathways
11.07 HRAS KRAS
32 11.01 HRAS KRAS
33 10.98 HRAS KRAS
34 10.98 CDKN2A TP53
35
Show member pathways
10.97 CDKN2A TP53
36 10.91 HRAS KRAS
37 10.79 CDKN2A HRAS KRAS TP53
38 10.67 HRAS KRAS
39 10.32 CCK GAST

GO Terms for Nasal Cavity Adenocarcinoma

Biological processes related to Nasal Cavity Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.8 CCK CDX2 HRAS KRAS
2 regulation of signaling receptor activity GO:0010469 9.67 CCK CXCL11 GAST PDYN
3 cell cycle arrest GO:0007050 9.61 CDKN2A HRAS TP53
4 intrinsic apoptotic signaling pathway GO:0097193 9.54 HRAS TP53
5 cell aging GO:0007569 9.52 HRAS TP53
6 cellular response to gamma radiation GO:0071480 9.51 HRAS TP53
7 cellular senescence GO:0090398 9.48 CDKN2A HRAS
8 regulation of long-term neuronal synaptic plasticity GO:0048169 9.46 HRAS KRAS
9 positive regulation of gene expression GO:0010628 9.46 CDKN2A HRAS KRAS TP53
10 positive regulation of cellular senescence GO:2000774 9.4 CDKN2A KRAS
11 positive regulation of protein oligomerization GO:0032461 9.32 CCK TP53
12 replicative senescence GO:0090399 9.26 CDKN2A TP53
13 response to isolation stress GO:0035900 8.96 HRAS KRAS
14 Ras protein signal transduction GO:0007265 8.92 CDKN2A HRAS KRAS TP53

Molecular functions related to Nasal Cavity Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 8.62 CCK PDYN

Sources for Nasal Cavity Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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