MCID: NSL003
MIFTS: 40

Nasal Cavity Adenocarcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Nasal Cavity Adenocarcinoma

MalaCards integrated aliases for Nasal Cavity Adenocarcinoma:

Name: Nasal Cavity Adenocarcinoma 12 15
Adenocarcinoma of Nasal Cavity 12 74
Adenocarcinoma of the Nasal Cavity 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4930
NCIt 51 C6015
UMLS 74 C1334920

Summaries for Nasal Cavity Adenocarcinoma

Disease Ontology : 12 A nasal cavity carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Nasal Cavity Adenocarcinoma, also known as adenocarcinoma of nasal cavity, is related to adenocarcinoma and prostatic acinar adenocarcinoma, and has symptoms including pain and rhinorrhea. An important gene associated with Nasal Cavity Adenocarcinoma is CXCL11 (C-X-C Motif Chemokine Ligand 11), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Etoposide and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include ovary, pancreas and thyroid, and related phenotypes are homeostasis/metabolism and digestive/alimentary

Related Diseases for Nasal Cavity Adenocarcinoma

Diseases related to Nasal Cavity Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 199)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 29.0 CDKN2A HRAS KRAS TP53
2 prostatic acinar adenocarcinoma 10.3 CDX2 KRT7
3 signet ring cell adenocarcinoma 10.3 CDX2 KRT7
4 ampulla of vater adenocarcinoma 10.3 CDX2 KRT7
5 ovarian mucinous neoplasm 10.3 CDX2 KRT7
6 gastric tubular adenocarcinoma 10.3 CDX2 KRT7
7 cystitis cystica 10.3 CDX2 KRT7
8 horseshoe kidney 10.3 CDX2 KRT7
9 ethmoid sinus cancer 10.3 CXCL11 HRAS
10 ethmoid sinus adenocarcinoma 10.3 CXCL11 HRAS
11 pancreatic mucinous cystadenoma 10.3 HRAS KRT7
12 ovary neuroendocrine neoplasm 10.3 CDX2 KRT7
13 appendix adenocarcinoma 10.3 CDX2 KRT7
14 mucinous adenofibroma 10.3 CDX2 KRT7
15 anus adenocarcinoma 10.3 CDX2 KRT7
16 glandular cystitis 10.3 CDX2 KRT7
17 space motion sickness 10.2 CCK GAST
18 duodenal gastrinoma 10.2 CCK GAST
19 melanomatosis 10.2 CDKN2A HRAS
20 bile reflux 10.2 CCK CDX2
21 epithelial predominant wilms' tumor 10.2 CDX2 KRT7
22 esophagus adenocarcinoma 10.2 CDX2 TP53
23 cervical adenosquamous carcinoma 10.2 CDKN2A KRT7
24 ovarian cystic teratoma 10.2 GAST KRT7
25 well-differentiated liposarcoma 10.2 CDKN2A KRT7
26 jejunal adenocarcinoma 10.2 CDX2 KRT7
27 ovarian mucinous adenocarcinoma 10.2 CDX2 KRT7
28 thymus adenocarcinoma 10.2 CDX2 KRT7
29 gastric diffuse adenocarcinoma 10.2 CDX2 KRT7
30 gallbladder adenoma 10.2 CDKN2A HRAS
31 chronic cystitis 10.2 CDX2 KRT7
32 inverted transitional papilloma 10.2 CDKN2A KRT7
33 eccrine sweat gland neoplasm 10.2 KRT7 TP53
34 acinar cell carcinoma 10.2 KRT7 TP53
35 postcholecystectomy syndrome 10.2 CCK GAST
36 opioid abuse 10.2 CCK PDYN
37 granulosa cell tumor of the ovary 10.2 KRT7 TP53
38 suppressor of tumorigenicity 3 10.1 CDKN2A TP53
39 tongue disease 10.1 CDKN2A TP53
40 penile disease 10.1 CDKN2A TP53
41 vulval paget's disease 10.1 CDKN2A KRT7
42 optic nerve neoplasm 10.1 CDKN2A TP53
43 verrucous carcinoma 10.1 CDKN2A TP53
44 adenoid basal cell carcinoma 10.1 CDKN2A KRT7
45 bile duct adenoma 10.1 CDKN2A KRT7
46 cervix small cell carcinoma 10.1 CDKN2A TP53
47 juvenile pilocytic astrocytoma 10.1 CDKN2A TP53
48 dedifferentiated liposarcoma 10.1 CDKN2A TP53
49 endocervical carcinoma 10.1 CDKN2A KRT7
50 villous adenoma 10.1 CDX2 KRAS

Graphical network of the top 20 diseases related to Nasal Cavity Adenocarcinoma:



Diseases related to Nasal Cavity Adenocarcinoma

Symptoms & Phenotypes for Nasal Cavity Adenocarcinoma

UMLS symptoms related to Nasal Cavity Adenocarcinoma:


pain, rhinorrhea

MGI Mouse Phenotypes related to Nasal Cavity Adenocarcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.97 CCK CDKN2A CDX2 GAST HRAS KRAS
2 digestive/alimentary MP:0005381 9.95 CDKN2A CDX2 GAST HRAS KRAS PDYN
3 endocrine/exocrine gland MP:0005379 9.91 CCK CDKN2A CDX2 GAST HRAS KRAS
4 neoplasm MP:0002006 9.73 CDKN2A CDX2 GAST HRAS KRAS TP53
5 no phenotypic analysis MP:0003012 9.63 CCK CDKN2A HRAS KRAS PDYN TP53
6 renal/urinary system MP:0005367 9.35 CCK HRAS KRAS KRT7 TP53
7 skeleton MP:0005390 9.1 CDKN2A CDX2 HRAS KRAS PDYN TP53

Drugs & Therapeutics for Nasal Cavity Adenocarcinoma

Drugs for Nasal Cavity Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 2 33419-42-0 36462
2
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
3
Ipilimumab Approved Phase 2 477202-00-9
4
nivolumab Approved Phase 2 946414-94-4
5 Etoposide phosphate Phase 2
6 Antineoplastic Agents, Phytogenic Phase 2
7 Topoisomerase Inhibitors Phase 2
8 Immunoglobulins Phase 2
9 Antibodies Phase 2
10 Antineoplastic Agents, Immunological Phase 2
11 Antibodies, Monoclonal Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Clinical Trial of Endoscopic Surgery Followed by Chemotherapy and Proton Radiation for the Treatment of Tumors in the Sinus and Nasal Passages Recruiting NCT03274414 Phase 2 Cisplatin;cisplatin and etoposide
2 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2

Search NIH Clinical Center for Nasal Cavity Adenocarcinoma

Genetic Tests for Nasal Cavity Adenocarcinoma

Anatomical Context for Nasal Cavity Adenocarcinoma

MalaCards organs/tissues related to Nasal Cavity Adenocarcinoma:

42
Ovary, Pancreas, Thyroid, Appendix, Cervix, Prostate, Tongue

Publications for Nasal Cavity Adenocarcinoma

Articles related to Nasal Cavity Adenocarcinoma:

# Title Authors Year
1
Intestinal and non-intestinal nasal cavity adenocarcinoma: Impact of wood dust exposure. ( 30201443 )
2018

Variations for Nasal Cavity Adenocarcinoma

Expression for Nasal Cavity Adenocarcinoma

Search GEO for disease gene expression data for Nasal Cavity Adenocarcinoma.

Pathways for Nasal Cavity Adenocarcinoma

Pathways related to Nasal Cavity Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.69 CDKN2A HRAS KRAS TP53
2 12.66 CDKN2A HRAS KRAS TP53
3
Show member pathways
12.61 CDKN2A HRAS KRAS TP53
4
Show member pathways
12.48 CDKN2A HRAS KRAS TP53
5
Show member pathways
12.39 CDKN2A CDX2 HRAS KRAS TP53
6 12.27 CDKN2A HRAS KRAS TP53
7
Show member pathways
12.18 CCK GAST HRAS KRAS
8 12.14 HRAS KRAS TP53
9
Show member pathways
12.11 HRAS KRAS TP53
10 12.1 CDKN2A HRAS KRAS TP53
11
Show member pathways
11.99 HRAS KRAS TP53
12 11.98 HRAS KRAS TP53
13 11.97 CDKN2A HRAS KRAS TP53
14
Show member pathways
11.96 HRAS KRAS TP53
15
Show member pathways
11.95 HRAS KRAS TP53
16
Show member pathways
11.85 HRAS KRAS TP53
17 11.81 HRAS KRAS TP53
18 11.79 HRAS KRAS TP53
19 11.76 CDKN2A HRAS KRAS TP53
20 11.74 CDKN2A HRAS TP53
21 11.52 CDKN2A HRAS KRAS TP53
22 11.43 HRAS KRAS TP53
23 11.42 HRAS KRAS TP53
24 11.39 HRAS KRAS TP53
25 11.3 CDKN2A HRAS KRAS TP53
26 11.21 HRAS KRAS
27 11.18 CDKN2A TP53
28 11.15 HRAS KRAS
29 11.15 HRAS KRAS
30
Show member pathways
11.13 HRAS KRAS
31 11.12 HRAS KRAS TP53
32
Show member pathways
11.07 HRAS KRAS
33 11 HRAS KRAS
34 10.98 HRAS KRAS
35 10.97 CDKN2A TP53
36
Show member pathways
10.97 CDKN2A TP53
37 10.92 HRAS KRAS
38 10.79 CDKN2A HRAS KRAS TP53
39 10.68 HRAS KRAS
40 10.32 CCK GAST

GO Terms for Nasal Cavity Adenocarcinoma

Biological processes related to Nasal Cavity Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.8 CCK CDX2 HRAS KRAS
2 regulation of signaling receptor activity GO:0010469 9.67 CCK CXCL11 GAST PDYN
3 cell cycle arrest GO:0007050 9.58 CDKN2A HRAS TP53
4 positive regulation of gene expression GO:0010628 9.56 CDKN2A HRAS KRAS TP53
5 intrinsic apoptotic signaling pathway GO:0097193 9.54 HRAS TP53
6 cell aging GO:0007569 9.52 HRAS TP53
7 cellular response to gamma radiation GO:0071480 9.51 HRAS TP53
8 cellular senescence GO:0090398 9.48 CDKN2A HRAS
9 regulation of long-term neuronal synaptic plasticity GO:0048169 9.46 HRAS KRAS
10 positive regulation of cellular senescence GO:2000774 9.43 CDKN2A KRAS
11 positive regulation of protein oligomerization GO:0032461 9.32 CCK TP53
12 replicative senescence GO:0090399 9.16 CDKN2A TP53
13 response to isolation stress GO:0035900 8.96 HRAS KRAS
14 Ras protein signal transduction GO:0007265 8.92 CDKN2A HRAS KRAS TP53

Sources for Nasal Cavity Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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