MCID: NSL008
MIFTS: 33

Nasal Cavity Cancer

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Nasal Cavity Cancer

MalaCards integrated aliases for Nasal Cavity Cancer:

Name: Nasal Cavity Cancer 12 15
Nasal Cavity Carcinoma 12 15 71
Malignant Neoplasm of Nasal Cavities 12
Malignant Tumor of the Nasal Cavity 12
Malignant Neoplasm of Nasal Cavity 71
Carcinoma of Nasal Cavity 12
Neoplasm of Nasal Cavity 71
Cancer of Nasal Cavity 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10811 DOID:4931
ICD9CM 34 160.0
NCIt 50 C4918 C9336
SNOMED-CT 67 93917007
ICD10 32 C30.0
UMLS 71 C0345630 C0728864 C1377785

Summaries for Nasal Cavity Cancer

Disease Ontology : 12 A nasal cavity cancer that has material basis in epithelial cells.

MalaCards based summary : Nasal Cavity Cancer, also known as nasal cavity carcinoma, is related to squamous cell papilloma and epithelial-myoepithelial carcinoma, and has symptoms including pain and rhinorrhea. An important gene associated with Nasal Cavity Cancer is CXCL11 (C-X-C Motif Chemokine Ligand 11), and among its related pathways/superpathways are Gastric cancer and Human T-cell leukemia virus 1 infection. Related phenotypes are digestive/alimentary and no phenotypic analysis

Related Diseases for Nasal Cavity Cancer

Diseases in the Nasal Cavity Cancer family:

Nasal Cavity Carcinoma in Situ

Diseases related to Nasal Cavity Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 393)
# Related Disease Score Top Affiliating Genes
1 squamous cell papilloma 30.0 TP53 HRAS CDKN2A
2 epithelial-myoepithelial carcinoma 30.0 TP53 KRT7 HRAS
3 myoepithelial carcinoma 30.0 TP53 KRT7 HRAS
4 papilloma 29.6 TP53 KRT7 KRT5 CDKN2A
5 nasal cavity adenocarcinoma 29.6 TP53 PDYN MLANA KRT7 HRAS CXCL11
6 squamous cell carcinoma 29.5 TP53 KRT7 HRAS CDKN2A
7 inverted papilloma 29.4 TP53 KRT7 KRT5 CDKN2A
8 adenoid cystic carcinoma 29.3 TP53 KRT7 KRT5 HRAS CDKN2A
9 keratinizing squamous cell carcinoma 29.1 TP53 NUTM1 KRT7 KRT5 CDKN2A
10 nasal cavity carcinoma in situ 11.3
11 sinonasal undifferentiated carcinoma 11.1
12 nasal cavity squamous cell carcinoma 11.1
13 transverse colon cancer 10.3 KRT7 HRAS
14 gallbladder benign neoplasm 10.3 KRT7 HRAS
15 mediastinal cancer 10.3 NUTM1 KRT7
16 wolffian duct adenocarcinoma 10.3 KRT7 HRAS
17 ovary neuroendocrine neoplasm 10.3 KRT7 CDX2
18 gastric signet ring cell adenocarcinoma 10.2 KRT7 CDX2
19 anal gland adenocarcinoma 10.2 KRT7 CDX2
20 anus adenocarcinoma 10.2 KRT7 CDX2
21 mucinous adenofibroma 10.2 KRT7 CDX2
22 adenosquamous colon carcinoma 10.2 KRT7 CDX2
23 bartholin's gland disease 10.2 KRT7 CDX2
24 urinary bladder villous adenoma 10.2 KRT7 CDX2
25 bartholin's gland carcinoma 10.2 KRT7 CDX2
26 vulva adenocarcinoma 10.2 KRT7 CDX2
27 female urethral cancer 10.2 KRT7 CDX2
28 cystitis cystica 10.2 KRT7 CDX2
29 mucinous intrahepatic cholangiocarcinoma 10.2 KRT7 CDX2
30 rectum neuroendocrine neoplasm 10.2 KRT7 CDX2
31 mucinous ovarian cystadenoma 10.2 KRT7 CDX2
32 bile duct cysts 10.2 KRT7 HRAS
33 sigmoid neoplasm 10.2 KRT7 CDX2
34 spiradenoma 10.2 TP53 KRT7
35 krukenberg carcinoma 10.2 KRT7 CDX2
36 jejunal cancer 10.2 KRT7 CDX2
37 jejunal adenocarcinoma 10.2 KRT7 CDX2
38 adenofibroma 10.2 TP53 KRT7
39 anal canal adenocarcinoma 10.2 KRT7 CDX2
40 mucinous bronchioloalveolar adenocarcinoma 10.2 KRT7 CDX2
41 descending colon cancer 10.2 HRAS CDX2
42 lymphoepithelioma-like thymic carcinoma 10.2 NUTM1 KRT5
43 ureter squamous cell carcinoma 10.2 KRT7 KRT5
44 gastric diffuse adenocarcinoma 10.2 KRT7 CDX2
45 linitis plastica 10.2 KRT7 CDX2
46 ceruminoma 10.2 KRT7 KRT5
47 maxillary sinus adenocarcinoma 10.2 TP53 CXCL11
48 subareolar duct papillomatosis 10.2 KRT7 KRT5
49 malignant acrospiroma 10.2 KRT7 KRT5
50 nipple benign neoplasm 10.2 KRT7 KRT5

Graphical network of the top 20 diseases related to Nasal Cavity Cancer:



Diseases related to Nasal Cavity Cancer

Symptoms & Phenotypes for Nasal Cavity Cancer

UMLS symptoms related to Nasal Cavity Cancer:


pain, rhinorrhea

MGI Mouse Phenotypes related to Nasal Cavity Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.43 CDKN2A CDX2 HRAS KRT5 PDYN TP53
2 no phenotypic analysis MP:0003012 9.02 CDKN2A HRAS MLANA PDYN TP53

Drugs & Therapeutics for Nasal Cavity Cancer

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Clinical Outcomes Protocol of Photon/Proton Beam Radiation Therapy for Cancers of the Nasal Cavity and/or Paranasal Sinuses Completed NCT00797498

Search NIH Clinical Center for Nasal Cavity Cancer

Genetic Tests for Nasal Cavity Cancer

Anatomical Context for Nasal Cavity Cancer

Publications for Nasal Cavity Cancer

Articles related to Nasal Cavity Cancer:

(show all 25)
# Title Authors PMID Year
1
Are Intraoral Stents Effective for Reducing the Severity of Oral Mucositis During Radiotherapy for Maxillary and Nasal Cavity Cancer? 61
32165135 2020
2
Molecular characterization of cancers with NTRK gene fusions. 61
30171197 2019
3
Primary surgical treatment of nasal vestibule cancer - therapeutic outcome and reconstructive strategies. 61
30098234 2018
4
Nasal cavity reirradiation: a challenging case for comparison between proton therapy and volumetric modulated arc therapy. 61
26166226 2016
5
Germline TP53 Mutation and Clinical Characteristics of Korean Patients With Li-Fraumeni Syndrome. 61
27374712 2016
6
Conjunctival Melanoma on 18F-FDG PET/CT as a Second Primary Cancer. 61
26646997 2016
7
Health-related quality of life of head and neck cancer patients with successful oncological treatment. 61
24986429 2015
8
(P092) definitive chemoradiotherapy or radiotherapy for unresectable, very locally advanced, or medically inoperable paranasal sinus and nasal cavity cancer. 61
25930909 2015
9
Definitive radiotherapy with or without chemotherapy for T3-4N0 squamous cell carcinoma of the maxillary sinus and nasal cavity. 61
20185459 2010
10
Stage III-IV sinonasal and nasal cavity carcinoma treated with three-dimensional conformal radiotherapy. 61
18705398 2008
11
Treatment of nasal cavity and paranasal sinus cancer with modern radiotherapy techniques in the postoperative setting--the MSKCC experience. 61
17161557 2007
12
[Epidemiologic analysis of 72 carcinomas of the nasal cavity and paranasal sinuses]. 61
17117693 2006
13
Prognostic factors in maxillary sinus and nasal cavity carcinoma. 61
15923101 2005
14
Sulindac sulfide-induced apoptosis in sinonasal cancer cells. 61
15880954 2005
15
[Prognostic factors of 60 nasal cavity carcinoma patients]. 61
12667333 2002
16
Cancer of the nasal cavity: survival and factors influencing prognosis. 61
12220216 2002
17
[Radiation treatment in the carcinoma of paranasal sinuses and nasal cavity]. 61
9082829 1996
18
Carcinomas of the nasal cavity. 61
1410570 1992
19
Ethmoid and upper nasal cavity carcinoma: treatment, results and complications. 61
2123986 1990
20
Nasal obstruction portending nasal cavity cancer. 61
2599810 1989
21
Carcinoma of the nasal cavity--results of primary and adjuvant radiotherapy. 61
2846481 1988
22
Paranasal sinuses and nasal cavity cancer: different radiotherapeutic options, results and late damages. 61
3810867 1986
23
Descriptive epidemiology of malignant neoplasms of nose, nasal cavities, middle ear and accessory sinuses. 61
6996871 1980
24
[Immediate and late results of the treatment of nasal cavity cancer]. 61
636621 1978
25
[Wegener's disease and nasal cavity cancer]. 61
855456 1977

Variations for Nasal Cavity Cancer

Expression for Nasal Cavity Cancer

Search GEO for disease gene expression data for Nasal Cavity Cancer.

Pathways for Nasal Cavity Cancer

GO Terms for Nasal Cavity Cancer

Biological processes related to Nasal Cavity Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell cycle arrest GO:0071158 9.43 TP53 CDKN2A
2 intrinsic apoptotic signaling pathway GO:0097193 9.4 TP53 HRAS
3 cellular response to gamma radiation GO:0071480 9.37 TP53 HRAS
4 cell aging GO:0007569 9.32 TP53 HRAS
5 cellular senescence GO:0090398 9.26 HRAS CDKN2A
6 replicative senescence GO:0090399 9.16 TP53 CDKN2A
7 cell cycle arrest GO:0007050 9.13 TP53 HRAS CDKN2A
8 Ras protein signal transduction GO:0007265 8.8 TP53 HRAS CDKN2A

Molecular functions related to Nasal Cavity Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MDM2/MDM4 family protein binding GO:0097371 8.62 TP53 CDKN2A

Sources for Nasal Cavity Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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