MCID: NSL022
MIFTS: 30

Nasal Cavity Disease

Categories: Respiratory diseases

Aliases & Classifications for Nasal Cavity Disease

MalaCards integrated aliases for Nasal Cavity Disease:

Name: Nasal Cavity Disease 12 15
Disorder of Nasal Cavity 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2163
NCIt 50 C27102
UMLS 73 C0339820

Summaries for Nasal Cavity Disease

MalaCards based summary : Nasal Cavity Disease, also known as disorder of nasal cavity, is related to cytokine deficiency and loeffler endocarditis. An important gene associated with Nasal Cavity Disease is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. Related phenotypes are Increased transferrin (TF) endocytosis and hematopoietic system

Wikipedia : 76 The nasal cavity (nasal fossa, or nasal passage) is a large air filled space above and behind the nose... more...

Related Diseases for Nasal Cavity Disease

Diseases related to Nasal Cavity Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 162)
# Related Disease Score Top Affiliating Genes
1 cytokine deficiency 10.9 IL13 IL5
2 loeffler endocarditis 10.9 IL5 RNASE3
3 angioimmunoblastic lymphadenopathy with dysproteinemia 10.9 IL13 IL5
4 pemphigoid gestationis 10.9 CCL11 IL5
5 intrinsic asthma 10.8 IL4 IL5 RNASE3
6 atopic keratoconjunctivitis 10.8 IL4 IL5 RNASE3
7 paragonimiasis 10.8 IL13 IL5 RNASE3
8 blepharoconjunctivitis 10.8 CCL11 IL4 RNASE3
9 pollen allergy 10.8 IL13 IL5 RNASE3
10 tropical endomyocardial fibrosis 10.8 IL10 IL4
11 vernal conjunctivitis 10.8 IL4 MS4A2 RNASE3
12 eosinophilic gastroenteritis 10.8 CCL11 IL5 RNASE3
13 chronic eosinophilic pneumonia 10.8 CCL11 IL5 RNASE3
14 intestinal schistosomiasis 10.8 IL13 IL4 IL5
15 chronic tic disorder 10.8 IL13 IL4 IL5
16 respiratory syncytial virus infectious disease 10.8 IL13 IL5
17 enterobiasis 10.7 IL13 IL4 IL5
18 strongyloidiasis 10.7 CCL11 IL13 IL5
19 physical urticaria 10.7 MS4A2 TRPV1
20 prurigo nodularis 10.7 RNASE3 TAC1
21 ascaris lumbricoides infection 10.7 IL13 IL5 TSLP
22 vasomotor rhinitis 10.7 RNASE3 TAC1 TLR9
23 night blindness, congenital stationary, type 1a 10.7 CCL11 IL13 IL5
24 sezary's disease 10.7 IL4 IL5 TLR9
25 hyperlucent lung 10.7 IL10 IL4
26 eye lymphoma 10.7 IL10 TLR9
27 ascaridiasis 10.7 IL10 IL13
28 cow milk allergy 10.7 IL10 IL5 RNASE3
29 lacrimal apparatus disease 10.7 IL10 TLR9 TRPV1
30 cough variant asthma 10.7 IL4 IL5 RNASE3 TRPV1
31 endomyocardial fibrosis 10.7 IL10 IL4
32 coccidiosis 10.6 IL10 IL4 TLR9
33 somatoform disorder 10.6 IL4 TAC1 TRPV1
34 bullous pemphigoid 10.6 CCL11 IL5 RNASE3
35 immunoglobulin a deficiency 1 10.6 IL10 IL4
36 bagassosis 10.6 CXCL8 IL5
37 genital herpes 10.6 IL10 IL4 TLR9
38 churg-strauss syndrome 10.6 IL10 IL5 RNASE3
39 extrinsic cardiomyopathy 10.6 IL10 IL4 TLR9
40 keratoconjunctivitis sicca 10.6 IL10 IL4 TLR9
41 opportunistic mycosis 10.6 IL10 IL4 TLR9
42 inflammatory bowel disease 4 10.6 IL13 IL4 IL5 RNASE3
43 beta-lactam allergy 10.6 IL10 IL13 IL4
44 latex allergy 10.6 IL13 IL4 IL5 RNASE3
45 urinary schistosomiasis 10.6 IL13 IL4 IL5 RNASE3
46 filariasis 10.6 IL10 IL5 TLR9
47 chronic meningitis 10.6 CCL11 IL5
48 mouth disease 10.6 IL10 TLR9 TRPV1
49 parasitic protozoa infectious disease 10.6 IL10 IL4 TLR9
50 paracoccidioidomycosis 10.6 IL10 IL4 IL5

Graphical network of the top 20 diseases related to Nasal Cavity Disease:



Diseases related to Nasal Cavity Disease

Symptoms & Phenotypes for Nasal Cavity Disease

GenomeRNAi Phenotypes related to Nasal Cavity Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased transferrin (TF) endocytosis GR00363-A 9.4 CXCL8 CYSLTR1 HRH1 IL10 IL13 IL5

MGI Mouse Phenotypes related to Nasal Cavity Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 IL4 CCL11 CHD7 IL5 MS4A2 HRH1
2 homeostasis/metabolism MP:0005376 9.97 IL33 IL4 CHD7 IL5 PDC HRH1
3 digestive/alimentary MP:0005381 9.92 IL4 CHD7 IL5 IL10 TLR9 IL13
4 immune system MP:0005387 9.8 IL4 CCL11 CHD7 IL5 CYSLTR1 MS4A2
5 respiratory system MP:0005388 9.28 IL4 CCL11 CHD7 IL5 CYSLTR1 IL10

Drugs & Therapeutics for Nasal Cavity Disease

Search Clinical Trials , NIH Clinical Center for Nasal Cavity Disease

Genetic Tests for Nasal Cavity Disease

Anatomical Context for Nasal Cavity Disease

Publications for Nasal Cavity Disease

Variations for Nasal Cavity Disease

Expression for Nasal Cavity Disease

Search GEO for disease gene expression data for Nasal Cavity Disease.

Pathways for Nasal Cavity Disease

Pathways related to Nasal Cavity Disease according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.31 CCL11 CXCL8 IL10 IL13 IL4 IL5
2
Show member pathways
13.26 CCL11 CXCL8 IL10 IL13 IL33 IL4
3
Show member pathways
12.75 CCL11 CXCL8 IL10 IL13 IL4 IL5
4
Show member pathways
12.68 CXCL8 IL13 IL33 IL4 TLR9
5
Show member pathways
12.55 CXCL8 IL10 IL13 IL4 IL5 TSLP
6
Show member pathways
12.33 IL10 IL13 IL4 IL5
7
Show member pathways
12.27 CCL11 CXCL8 IL13 IL4 IL5
8
Show member pathways
12.1 CCL11 CXCL8 IL4 TLR9
9 12.08 CXCL8 IL10 IL13 TAC1
10
Show member pathways
12 CCL11 CXCL8 IL10 IL13 IL4 IL5
11 11.91 IL10 IL4 IL5 PTGDR2
12 11.89 CCL11 CXCL8 IL10 IL13 IL4
13 11.74 CXCL8 IL13 IL4 IL5
14
Show member pathways
11.65 CXCL8 IL4 IL5
15 11.6 CCL11 IL10 IL4 IL5
16 11.45 CXCL8 IL10 IL13 IL4
17 11.45 CCL11 CXCL8 IL13 IL4 IL5
18 11.44 CXCL8 IL10 TLR9
19 11.41 CCL11 CXCL8 TSLP
20 11.15 IL10 IL13 IL4 IL5
21 11.1 CCL11 IL10 IL13 IL33 IL4 IL5
22 11.07 IL10 IL13 IL33 IL4 IL5 PTGDR2
23 11.06 IL13 IL33 IL4 IL5 TSLP
24 11.04 IL10 IL13 IL4 IL5

GO Terms for Nasal Cavity Disease

Cellular components related to Nasal Cavity Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 CCL11 CXCL8 IL10 IL13 IL33 IL4
2 extracellular space GO:0005615 9.36 CCL11 CXCL8 IL10 IL13 IL33 IL4

Biological processes related to Nasal Cavity Disease according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.88 CXCL8 IL10 IL13 TAC1
2 cytokine-mediated signaling pathway GO:0019221 9.88 CCL11 CXCL8 IL10 IL13 IL4 IL5
3 chemotaxis GO:0006935 9.83 CCL11 CXCL8 CYSLTR1 PTGDR2
4 neuropeptide signaling pathway GO:0007218 9.8 CYSLTR1 PTGDR2 TAC1
5 positive regulation of inflammatory response GO:0050729 9.78 IL33 TLR9 TSLP
6 immune response GO:0006955 9.76 CCL11 CXCL8 IL10 IL13 IL4 IL5
7 positive regulation of interleukin-6 production GO:0032755 9.71 IL33 TLR9 TSLP
8 negative regulation of endothelial cell apoptotic process GO:2000352 9.67 IL10 IL13 IL4
9 positive regulation of macrophage activation GO:0043032 9.63 IL10 IL13 IL33
10 microglial cell activation GO:0001774 9.62 IL13 TRPV1
11 positive regulation of B cell proliferation GO:0030890 9.62 IL13 IL4 IL5 TLR9
12 positive regulation of immunoglobulin secretion GO:0051024 9.61 IL33 IL5
13 response to molecule of bacterial origin GO:0002237 9.61 CXCL8 IL10 TLR9
14 positive regulation of interleukin-5 production GO:0032754 9.59 IL33 TSLP
15 positive regulation of immunoglobulin production GO:0002639 9.58 IL13 TLR9
16 positive regulation of MHC class II biosynthetic process GO:0045348 9.57 IL10 IL4
17 queuosine biosynthetic process GO:0008616 9.56 PDC PDCL
18 regulation of signaling receptor activity GO:0010469 9.56 CCL11 CXCL8 IL10 IL13 IL33 IL4
19 negative regulation of interleukin-8 production GO:0032717 9.55 IL10 TLR9
20 positive regulation of interleukin-13 production GO:0032736 9.54 IL33 IL4 TSLP
21 regulation of isotype switching GO:0045191 9.51 IL10 IL4
22 negative regulation of complement-dependent cytotoxicity GO:1903660 9.48 IL13 IL4
23 type 2 immune response GO:0042092 9.43 IL10 IL33 IL4
24 inflammatory response GO:0006954 9.32 CCL11 CXCL8 HRH1 IL10 IL13 IL5
25 G-protein coupled receptor signaling pathway GO:0007186 10.14 CCL11 CXCL8 CYSLTR1 HRH1 PDC PTGDR2

Molecular functions related to Nasal Cavity Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.23 CCL11 CXCL8 IL10 IL13 IL33 IL4
2 queuine tRNA-ribosyltransferase activity GO:0008479 8.96 PDC PDCL

Sources for Nasal Cavity Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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