MCID: NSL022
MIFTS: 29

Nasal Cavity Disease

Categories: Respiratory diseases

Aliases & Classifications for Nasal Cavity Disease

MalaCards integrated aliases for Nasal Cavity Disease:

Name: Nasal Cavity Disease 12 15
Disorder of Nasal Cavity 74

Classifications:



External Ids:

Disease Ontology 12 DOID:2163
NCIt 51 C27102
UMLS 74 C0339820

Summaries for Nasal Cavity Disease

MalaCards based summary : Nasal Cavity Disease, also known as disorder of nasal cavity, is related to papillary conjunctivitis and cytokine deficiency. An important gene associated with Nasal Cavity Disease is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. Affiliated tissues include skin, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 77 The nasal cavity is a large, air-filled space above and behind the nose in the middle of the face. The... more...

Related Diseases for Nasal Cavity Disease

Diseases related to Nasal Cavity Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)
# Related Disease Score Top Affiliating Genes
1 papillary conjunctivitis 10.5 CCL11 IL4
2 cytokine deficiency 10.5 IL13 IL5
3 loeffler endocarditis 10.5 IL5 RNASE3
4 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL13 IL5
5 pemphigoid gestationis 10.4 CCL11 IL5
6 respiratory syncytial virus infectious disease 10.4 IL13 IL5
7 cough variant asthma 10.4 IL4 IL5 RNASE3
8 parasitic ichthyosporea infectious disease 10.4 IL4 RHNO1
9 tropical endomyocardial fibrosis 10.4 IL10 IL4
10 atopic keratoconjunctivitis 10.4 IL4 IL5 RNASE3
11 paragonimiasis 10.4 IL13 IL5 RNASE3
12 endomyocardial fibrosis 10.4 IL10 IL4
13 intrinsic asthma 10.4 IL4 IL5 RNASE3
14 rhinosporidiosis 10.4 IL4 RHNO1
15 cephalosporin allergy 10.4 IL10 IL5
16 prurigo nodularis 10.4 RNASE3 TAC1
17 vernal conjunctivitis 10.4 IL4 MS4A2 RNASE3
18 intestinal schistosomiasis 10.4 IL13 IL4 IL5
19 chronic tic disorder 10.4 IL13 IL4 IL5
20 blepharoconjunctivitis 10.4 CCL11 IL4 RNASE3
21 hyperlucent lung 10.4 IL10 IL4
22 giant papillary conjunctivitis 10.4 CCL11 IL4 RNASE3
23 enterobiasis 10.4 IL13 IL4 IL5
24 chronic eosinophilic pneumonia 10.4 CCL11 IL5 RNASE3
25 ascaridiasis 10.4 IL10 IL13
26 tungiasis 10.4 IL10 IL4
27 ascaris lumbricoides infection 10.4 IL13 IL5 TSLP
28 vasomotor rhinitis 10.4 RNASE3 TAC1
29 chronic meningitis 10.4 CCL11 IL5
30 strongyloidiasis 10.4 CCL11 IL13 IL5
31 mikulicz disease 10.4 IL5 PTGDR2
32 sinusitis 10.4 CYSLTR1 IL5 RNASE3
33 cow milk allergy 10.4 IL10 IL5 RNASE3
34 night blindness, congenital stationary, type 1a 10.3 CCL11 IL13 IL5
35 penicillin allergy 10.3 IL13 IL4
36 gaucher disease, type ii 10.3 IL10 IL4 IL5
37 scleritis 10.3 IL4 IL5
38 filarial elephantiasis 10.3 IL10 IL4 IL5
39 churg-strauss syndrome 10.3 IL10 IL5 RNASE3
40 beta-lactam allergy 10.3 IL10 IL13 IL4
41 necatoriasis 10.3 IL10 IL5
42 vulvovaginitis 10.3 CCL11 IL10
43 bullous pemphigoid 10.3 CCL11 IL5 RNASE3
44 maxillary sinusitis 10.3 RHNO1 RNASE3
45 mycoplasma pneumoniae pneumonia 10.3 IL10 IL13 IL4
46 inflammatory bowel disease 4 10.3 IL13 IL4 IL5 RNASE3
47 paracoccidioidomycosis 10.3 IL10 IL4 IL5
48 scabies 10.3 CCL11 IL10
49 urinary schistosomiasis 10.3 IL13 IL4 IL5 RNASE3
50 retinitis pigmentosa 22 10.3 IL10 IL4

Graphical network of the top 20 diseases related to Nasal Cavity Disease:



Diseases related to Nasal Cavity Disease

Symptoms & Phenotypes for Nasal Cavity Disease

MGI Mouse Phenotypes related to Nasal Cavity Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 CCL11 CHD7 FOXP3 HRH1 IL10 IL13
2 homeostasis/metabolism MP:0005376 9.93 CHD7 FOXP3 HRH1 IL10 IL13 IL33
3 digestive/alimentary MP:0005381 9.92 CHD7 FOXP3 IL10 IL13 IL33 IL4
4 immune system MP:0005387 9.77 CCL11 CHD7 CYSLTR1 FOXP3 HRH1 IL10
5 respiratory system MP:0005388 9.32 CCL11 CHD7 CYSLTR1 FOXP3 IL10 IL13

Drugs & Therapeutics for Nasal Cavity Disease

Search Clinical Trials , NIH Clinical Center for Nasal Cavity Disease

Genetic Tests for Nasal Cavity Disease

Anatomical Context for Nasal Cavity Disease

MalaCards organs/tissues related to Nasal Cavity Disease:

42
Skin

Publications for Nasal Cavity Disease

Variations for Nasal Cavity Disease

Expression for Nasal Cavity Disease

Search GEO for disease gene expression data for Nasal Cavity Disease.

Pathways for Nasal Cavity Disease

Pathways related to Nasal Cavity Disease according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.65 CCL11 FOXP3 ICOSLG IL10 IL13 IL4
2
Show member pathways
12.47 FOXP3 IL10 IL13 IL4 IL5
3
Show member pathways
12.29 IL10 IL13 IL4 IL5 TSLP
4
Show member pathways
12.2 CCL11 IL13 IL4 IL5
5
Show member pathways
11.96 CCL11 IL10 IL13 IL4 IL5
6 11.88 IL10 IL4 IL5 PTGDR2
7 11.85 CCL11 IL10 IL13 IL4
8 11.67 IL13 IL4 IL5
9
Show member pathways
11.63 FOXP3 IL4 IL5
10 11.61 CCL11 IL10 IL13 IL4
11 11.53 CCL11 IL10 IL4 IL5
12 11.5 CCL11 IL13 IL4 IL5
13 11.42 IL10 IL13 IL4
14 11.4 IL10 IL13 IL33 IL4 IL5 PTGDR2
15 11.13 IL10 IL13 IL4 IL5
16 11.11 CCL11 IL10 IL13 IL4 IL5
17 11.06 IL13 IL33 IL4 IL5 TSLP
18 11.04 IL10 IL13 IL4 IL5
19 10.89 CCL11 IL10 IL13 IL4 IL5
20 10.83 CCL11 FOXP3 IL10 IL13 IL33 IL4

GO Terms for Nasal Cavity Disease

Cellular components related to Nasal Cavity Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CCL11 IL10 IL13 IL33 IL4 IL5
2 extracellular space GO:0005615 9.28 CCL11 IL10 IL13 IL33 IL4 IL5

Biological processes related to Nasal Cavity Disease according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.8 CCL11 IL10 IL13 IL4 IL5
2 immune response GO:0006955 9.8 CCL11 IL10 IL13 IL4 IL5 MS4A2
3 neuropeptide signaling pathway GO:0007218 9.75 CYSLTR1 PTGDR2 TAC1
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.73 IL13 IL4 TSLP
5 T cell activation GO:0042110 9.7 FOXP3 ICOSLG IL4
6 positive regulation of B cell proliferation GO:0030890 9.65 IL13 IL4 IL5
7 negative regulation of endothelial cell apoptotic process GO:2000352 9.63 IL10 IL13 IL4
8 positive regulation of immunoglobulin secretion GO:0051024 9.57 IL33 IL5
9 positive regulation of interleukin-5 production GO:0032754 9.55 IL33 TSLP
10 positive regulation of MHC class II biosynthetic process GO:0045348 9.54 IL10 IL4
11 negative regulation of interferon-gamma production GO:0032689 9.54 FOXP3 IL10 IL33
12 regulation of isotype switching GO:0045191 9.51 IL10 IL4
13 positive regulation of macrophage activation GO:0043032 9.5 IL10 IL13 IL33
14 regulation of signaling receptor activity GO:0010469 9.5 CCL11 IL10 IL13 IL33 IL4 IL5
15 type 2 immune response GO:0042092 9.49 IL10 IL4
16 negative regulation of complement-dependent cytotoxicity GO:1903660 9.43 IL13 IL4
17 positive regulation of interleukin-13 production GO:0032736 9.33 IL33 IL4 TSLP
18 inflammatory response GO:0006954 9.17 CCL11 HRH1 IL10 IL13 IL5 MS4A2

Molecular functions related to Nasal Cavity Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CCL11 IL10 IL13 IL33 IL4 IL5

Sources for Nasal Cavity Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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