MCID: NSL022
MIFTS: 32

Nasal Cavity Disease

Categories: Respiratory diseases

Aliases & Classifications for Nasal Cavity Disease

MalaCards integrated aliases for Nasal Cavity Disease:

Name: Nasal Cavity Disease 12 15
Disorder of Nasal Cavity 70

Classifications:



External Ids:

Disease Ontology 12 DOID:2163
NCIt 50 C27102
SNOMED-CT 67 232340005
UMLS 70 C0339820

Summaries for Nasal Cavity Disease

MalaCards based summary : Nasal Cavity Disease, also known as disorder of nasal cavity, is related to cytokine deficiency and aztreonam allergy. An important gene associated with Nasal Cavity Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Related phenotypes are hematopoietic system and digestive/alimentary

Wikipedia : 73 The nasal cavity is a large, air-filled space above and behind the nose in the middle of the face. The... more...

Related Diseases for Nasal Cavity Disease

Diseases related to Nasal Cavity Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 644)
# Related Disease Score Top Affiliating Genes
1 cytokine deficiency 10.6 IL5 IL13
2 aztreonam allergy 10.5 IL5 IL13
3 acute asthma 10.5 RNASE3 IL5 IL4
4 atopic keratoconjunctivitis 10.5 RNASE3 IL5 IL4
5 cefaclor allergy 10.5 IL5 IL13
6 vernal conjunctivitis 10.5 RNASE3 IL4 CCR6
7 cough variant asthma 10.5 RNASE3 IL5 IL4
8 childhood-onset asthma 10.5 RNASE3 IL13
9 ceftriaxone allergy 10.5 IL5 IL13 IL10
10 cow milk allergy 10.5 IL5 IL4 IL10
11 orange allergy 10.5 PDCL IL5 IL13
12 loeffler syndrome 10.5 IL5 IL33 IL13
13 punctate inner choroidopathy 10.5 TNF IL10
14 paragonimiasis 10.5 RNASE3 IL5 IL13
15 vasomotor rhinitis 10.5 RNASE3 IL5 IL13
16 inflammatory bowel disease 18 10.5 IL4 IL10 CCR6
17 immunodeficiency 35 10.5 IL10 ICOSLG CCR6
18 eosinophilic gastritis 10.5 IL5 IL13 CCL11
19 psoriasis 15 10.5 TSLP IL4 IL13
20 cefuroxime allergy 10.5 IL5 IL13
21 beta-lactam allergy 10.5 IL4 IL13 IL10
22 patulous eustachian tube 10.5 RNASE3 IL5 CCL11
23 immunodeficiency 16 10.5 ICOSLG CD4 CCR6
24 pemphigoid gestationis 10.5 RNASE3 IL5 CCL11
25 metal allergy 10.5 IL4 IL10 CD4
26 autoimmune glomerulonephritis 10.5 ICOSLG CD4 CCR6
27 penicillin allergy 10.5 IL4 IL13 IL10
28 subcutaneous mycosis 10.5 IL10 CD4 CCR6
29 tropical endomyocardial fibrosis 10.5 TNF IL4 IL10
30 external pathological resorption 10.5 TNF IL6
31 drug allergy 10.5 IL5 IL13 CD4
32 pustulosis palmaris et plantaris 10.5 TNF IL5 CCR6
33 immunoglobulin alpha deficiency 10.5 ICOSLG CD4 CCR6
34 kimura disease 10.5 RNASE3 IL5 IL4 IL13
35 herpes simplex virus keratitis 10.5 CXCL8 CD4 CCR6
36 anemia, autoimmune hemolytic 10.5 ICOSLG CD4 CCR6
37 wells syndrome 10.5 RNASE3 IL5 CXCL8
38 chromium allergic contact dermatitis 10.5 IL5 IL4 IL13 IL10
39 evans' syndrome 10.5 IL10 CD4 CCR6
40 t cell deficiency 10.5 ICOSLG CD4 CCR6
41 parasitic ectoparasitic infectious disease 10.5 IL4 CD4 CCR6
42 mansonelliasis 10.5 IL5 IL10 CXCL8
43 scorpion envenomation 10.5 TNF IL6
44 nasopharyngitis 10.5 TNF IL5 CCR6
45 seborrheic dermatitis 10.5 FLG CD4 CCR6
46 corticosteroid allergy 10.5 PDCL FLG
47 physiological polycythemia 10.5 TNF IL6
48 igg4-related disease 10.5 IL4 IL33 ICOSLG CCR6
49 loeffler endocarditis 10.5 RNASE3 IL5
50 respiratory syncytial virus infectious disease 10.5 IL5 IL13

Graphical network of the top 20 diseases related to Nasal Cavity Disease:



Diseases related to Nasal Cavity Disease

Symptoms & Phenotypes for Nasal Cavity Disease

MGI Mouse Phenotypes related to Nasal Cavity Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 CCL11 CCR6 CD4 HRH1 IL10 IL13
2 digestive/alimentary MP:0005381 9.91 CD4 IL10 IL13 IL33 IL4 IL5
3 immune system MP:0005387 9.77 CCL11 CCR6 CD4 HRH1 IL10 IL13
4 respiratory system MP:0005388 9.28 CCL11 IL10 IL13 IL33 IL4 IL5

Drugs & Therapeutics for Nasal Cavity Disease

Search Clinical Trials , NIH Clinical Center for Nasal Cavity Disease

Genetic Tests for Nasal Cavity Disease

Anatomical Context for Nasal Cavity Disease

Publications for Nasal Cavity Disease

Articles related to Nasal Cavity Disease:

(show all 11)
# Title Authors PMID Year
1
TREATMENT OF MYCOTIC RHINOSINUSITIS IN A BENNETT'S WALLABY ( MACROPUS RUFOGRISEUS) USING TOPICAL VORICONAZOLE SUSPENDED IN A REVERSE THERMODYNAMIC PLURONIC GEL. 61
29517429 2018
2
CT of Anatomic Variants of the Paranasal Sinuses and Nasal Cavity: Poor Correlation With Radiologically Significant Rhinosinusitis but Importance in Surgical Planning. 61
26001236 2015
3
Orbital actinomycotic mycetoma caused by Streptomyces cinnamoneus. 61
28491361 2015
4
A whiff of trouble: tumours of the nasal cavity and their mimics. 61
24525221 2014
5
Sinonasal melanoma: survival and prognostic implications based on site of involvement. 61
24190249 2014
6
[Combined middle meatus and expand pre-lacrimal recess-maxillary sinus approach for endoscopic maxillary sinus surgery]. 61
23451474 2012
7
Intracranial nasal natural killer/T-cell lymphoma: immunopathologically-confirmed case and review of literature. 61
16283442 2005
8
Endoscopic management of inverted papillomas of the nose and paranasal sinuses. 61
12735164 2003
9
Nasopharyngeal cryptococcosis. 61
9258419 1997
10
Cryptococcosis in cats: clinical and mycological assessment of 29 cases and evaluation of treatment using orally administered fluconazole. 61
1588463 1992
11
Radiotherapy of malignant nasal tumors in 21 dogs. 61
6629976 1983

Variations for Nasal Cavity Disease

Expression for Nasal Cavity Disease

Search GEO for disease gene expression data for Nasal Cavity Disease.

Pathways for Nasal Cavity Disease

Pathways related to Nasal Cavity Disease according to GeneCards Suite gene sharing:

(show all 46)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.08 TNF RNASE3 IL6 IL5 IL4 IL33
2
Show member pathways
13.86 TNF IL6 IL5 IL4 IL13 IL10
3
Show member pathways
13.7 TSLP TNF IL6 IL5 IL4 IL33
4
Show member pathways
13.57 TNF IL6 IL5 IL4 IL13 IL10
5
Show member pathways
13.46 TNF IL6 IL5 IL4 IL13 IL10
6
Show member pathways
13.4 TNF IL6 IL5 IL4 IL33 IL13
7
Show member pathways
13.29 TNF IL6 IL5 IL4 IL13 IL10
8
Show member pathways
12.8 TNF RNASE3 IL6 IL5 IL4 IL13
9
Show member pathways
12.67 TNF IL6 IL5 IL4 IL10 CD4
10
Show member pathways
12.65 TNF IL4 IL10 ICOSLG CD4
11
Show member pathways
12.64 TNF IL6 IL5 IL4 IL13 IL10
12
Show member pathways
12.49 TSLP IL6 IL5 IL4 IL13 IL10
13
Show member pathways
12.41 TNF IL6 IL10 CXCL8 CCR6 CCL11
14
Show member pathways
12.37 TNF IL6 IL5 IL4 IL13 CXCL8
15
Show member pathways
12.3 TNF IL6 IL5 IL4 IL13 IL10
16
Show member pathways
12.26 TNF IL6 IL4 CXCL8 CCL11
17 12.25 TNF IL6 IL13 IL10 CXCL8
18 12.16 TNF IL6 IL10 CXCL8 CD4
19 12.09 TNF PTGDR2 IL6 IL5 IL4 IL10
20 12.06 TNF IL6 IL4 CXCL8
21 12.06 TNF IL6 IL4 IL13 IL10 CXCL8
22 12 TNF IL6 IL5 IL4 CD4
23 11.99 TNF IL6 IL10 CXCL8
24 11.88 IL6 IL5 IL4 IL13 CXCL8
25
Show member pathways
11.85 TNF IL6 IL10 CD4
26 11.84 TNF IL6 IL10 CXCL8
27
Show member pathways
11.84 TNF IL5 IL4 CXCL8
28 11.82 TNF IL6 IL10 CD4
29 11.77 TNF IL6 IL5 IL4 IL10 ICOSLG
30 11.75 IL5 IL4 IL10 CCL11
31 11.71 TNF IL6 IL5 IL4 IL13 CXCL8
32
Show member pathways
11.67 TNF IL6 CXCL8
33 11.63 TNF IL6 CXCL8
34 11.63 TNF IL6 IL10 CXCL8
35 11.6 TSLP IL6 CXCL8 CCL11
36 11.6 TNF IL6 IL4 IL13 IL10 CXCL8
37 11.46 IL5 IL4 IL33 IL13 IL10 CD4
38 11.43 TNF IL6 IL10
39 11.4 TNF IL6 IL10
40 11.29 IL5 IL4 IL13 IL10
41 11.23 TSLP TNF PTGDR2 IL5 IL4 IL33
42 11.2 TSLP TNF IL6 IL5 IL4 IL33
43 11.12 TNF IL6 CXCL8
44 11.04 TNF IL6 IL5 IL4 IL13 IL10
45 10.96 TNF IL6 IL5 IL4 IL13 IL10
46 10.89 IL6 IL5 IL4 IL13

GO Terms for Nasal Cavity Disease

Cellular components related to Nasal Cavity Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 TSLP TNF RNASE3 IL6 IL5 IL4
2 external side of plasma membrane GO:0009897 9.55 TNF IL13 ICOSLG CD4 CCR6
3 extracellular space GO:0005615 9.4 TSLP TNF RNASE3 MIR19A IL6 IL5

Biological processes related to Nasal Cavity Disease according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 10.14 TNF IL6 IL5 IL4 IL10 CD4
2 signal transduction GO:0007165 10.13 TSLP PTGDR2 PDCL IL6 IL5 IL4
3 positive regulation of gene expression GO:0010628 10.06 TNF IL6 IL4 IL33 IL13 CXCL8
4 cellular response to lipopolysaccharide GO:0071222 9.95 TNF IL6 IL10 CXCL8
5 negative regulation of inflammatory response GO:0050728 9.92 MIR19A IL4 IL13 IL10
6 chemotaxis GO:0006935 9.92 RNASE3 PTGDR2 CXCL8 CCR6 CCL11
7 inflammatory response GO:0006954 9.91 TNF IL6 IL5 IL13 HRH1 CXCL8
8 positive regulation of DNA-binding transcription factor activity GO:0051091 9.88 TNF IL6 IL5 IL10
9 negative regulation of interleukin-6 production GO:0032715 9.87 TNF MIR19A IL10
10 chemokine-mediated signaling pathway GO:0070098 9.87 CXCL8 CCR6 CCL11
11 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.87 TSLP RNASE3 CXCL8
12 response to glucocorticoid GO:0051384 9.86 TNF IL6 IL10
13 positive regulation of interleukin-6 production GO:0032755 9.86 TSLP TNF IL6 IL33
14 positive regulation of T cell proliferation GO:0042102 9.85 IL6 IL4 CD4
15 positive regulation of smooth muscle cell proliferation GO:0048661 9.85 TNF IL6 IL13
16 defense response to Gram-negative bacterium GO:0050829 9.85 TSLP RNASE3 IL6 CD4
17 humoral immune response GO:0006959 9.84 TNF IL6 CCR6
18 positive regulation of cytokine production GO:0001819 9.83 TNF IL33 IL10
19 T cell activation GO:0042110 9.81 IL4 ICOSLG CD4
20 positive regulation of B cell proliferation GO:0030890 9.8 IL5 IL4 IL13
21 negative regulation of endothelial cell apoptotic process GO:2000352 9.79 IL4 IL13 IL10
22 B cell activation GO:0042113 9.79 MIR19A IL4 ICOSLG
23 microglial cell activation GO:0001774 9.77 TNF IL4 IL13
24 positive regulation of chemokine production GO:0032722 9.76 TSLP TNF IL6 IL33
25 negative regulation of neurogenesis GO:0050768 9.74 TNF IL6 CCL11
26 positive regulation of interleukin-10 production GO:0032733 9.73 TSLP IL6 IL4 IL13
27 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.73 TSLP TNF MIR19A IL6 IL4 IL13
28 positive regulation of macrophage activation GO:0043032 9.71 IL33 IL13 IL10
29 positive regulation of JAK-STAT cascade GO:0046427 9.71 TNF IL6 IL5 IL10
30 positive regulation of podosome assembly GO:0071803 9.7 TNF IL5
31 response to molecule of bacterial origin GO:0002237 9.7 IL10 CXCL8
32 positive regulation of interleukin-5 production GO:0032754 9.7 TSLP IL33
33 positive regulation of mast cell degranulation GO:0043306 9.69 IL4 IL13
34 positive regulation of neuroinflammatory response GO:0150078 9.69 TNF IL6 IL33
35 negative regulation of lipid storage GO:0010888 9.68 TNF IL6
36 endothelial cell apoptotic process GO:0072577 9.68 TNF IL10
37 vascular endothelial growth factor production GO:0010573 9.67 TNF IL6
38 positive regulation of MHC class II biosynthetic process GO:0045348 9.67 IL4 IL33 IL10
39 positive regulation of mononuclear cell migration GO:0071677 9.65 TNF IL4
40 negative regulation of cytokine production involved in immune response GO:0002719 9.65 TNF IL10
41 positive regulation of interleukin-13 production GO:0032736 9.65 TSLP IL4 IL33
42 positive regulation of STAT cascade GO:1904894 9.64 TSLP IL6
43 type 2 immune response GO:0042092 9.64 IL4 IL10
44 negative regulation of complement-dependent cytotoxicity GO:1903660 9.61 IL4 IL13
45 cytokine-mediated signaling pathway GO:0019221 9.61 TNF IL6 IL5 IL4 IL13 IL10
46 regulation of isotype switching GO:0045191 9.6 IL4 IL10
47 positive regulation of immunoglobulin production GO:0002639 9.55 IL6 IL5 IL33 IL13 IL10
48 immune response GO:0006955 9.36 TNF PTGDR2 IL6 IL5 IL4 IL13

Molecular functions related to Nasal Cavity Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 TSLP TNF IL6 IL5 IL4 IL33
2 growth factor activity GO:0008083 9.26 IL6 IL5 IL4 IL10

Sources for Nasal Cavity Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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