MCID: NSL022
MIFTS: 32

Nasal Cavity Disease

Categories: Respiratory diseases

Aliases & Classifications for Nasal Cavity Disease

MalaCards integrated aliases for Nasal Cavity Disease:

Name: Nasal Cavity Disease 12 15
Disorder of Nasal Cavity 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2163
NCIt 50 C27102
UMLS 73 C0339820

Summaries for Nasal Cavity Disease

MalaCards based summary : Nasal Cavity Disease, also known as disorder of nasal cavity, is related to papillary conjunctivitis and cytokine deficiency. An important gene associated with Nasal Cavity Disease is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. Affiliated tissues include lung, skin and bone, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 The nasal cavity is a large air filled space above and behind the nose in the middle of the face. The... more...

Related Diseases for Nasal Cavity Disease

Diseases related to Nasal Cavity Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 papillary conjunctivitis 10.3 CCL11 IL4
2 cytokine deficiency 10.3 IL13 IL5
3 loeffler endocarditis 10.3 IL5 RNASE3
4 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL13 IL5
5 pemphigoid gestationis 10.3 CCL11 IL5
6 physical urticaria 10.3 MS4A2 TRPV1
7 atopic keratoconjunctivitis 10.3 IL4 IL5 RNASE3
8 paragonimiasis 10.3 IL13 IL5 RNASE3
9 intrinsic asthma 10.3 IL4 IL5 RNASE3
10 vernal conjunctivitis 10.2 IL4 MS4A2 RNASE3
11 tropical endomyocardial fibrosis 10.2 IL10 IL4
12 blepharoconjunctivitis 10.2 CCL11 IL4 RNASE3
13 endomyocardial fibrosis 10.2 IL10 IL4
14 cephalosporin allergy 10.2 IL10 IL5
15 parasitic ichthyosporea infectious disease 10.2 IL4 RHNO1
16 respiratory syncytial virus infectious disease 10.2 IL13 IL5
17 giant papillary conjunctivitis 10.2 CCL11 IL4 RNASE3
18 stevens-johnson syndrome/toxic epidermal necrolysis 10.2 IL13 IL5 TLR9
19 prurigo nodularis 10.2 RNASE3 TAC1
20 intestinal schistosomiasis 10.2 IL13 IL4 IL5
21 chronic tic disorder 10.2 IL13 IL4 IL5
22 yellow fever 10.2 IL4 IL5 TLR9
23 enterobiasis 10.2 IL13 IL4 IL5
24 rhinosporidiosis 10.2 IL4 RHNO1
25 strongyloidiasis 10.2 CCL11 IL13 IL5
26 hyperlucent lung 10.2 IL10 IL4
27 sezary's disease 10.2 IL4 IL5 TLR9
28 ascaris lumbricoides infection 10.2 IL13 IL5 TSLP
29 sinusitis 10.2 CYSLTR1 IL5 RNASE3
30 mikulicz disease 10.2 IL5 PTGDR2
31 night blindness, congenital stationary, type 1a 10.2 CCL11 IL13 IL5
32 eye lymphoma 10.2 IL10 TLR9
33 nut allergy 10.2 IL5 PTGDR2 TLR9
34 ascaridiasis 10.2 IL10 IL13
35 tungiasis 10.2 IL10 IL4
36 cow milk allergy 10.2 IL10 IL5 RNASE3
37 lacrimal apparatus disease 10.2 IL10 TLR9 TRPV1
38 cough variant asthma 10.2 IL4 IL5 RNASE3 TRPV1
39 somatoform disorder 10.2 IL4 TAC1 TRPV1
40 vasomotor rhinitis 10.2 RNASE3 TAC1
41 trichuriasis 10.2 IL10 IL13 RNASE3
42 bullous pemphigoid 10.2 CCL11 IL5 RNASE3
43 coccidiosis 10.2 IL10 IL4 TLR9
44 gaucher disease, type ii 10.2 IL10 IL4 IL5
45 genital herpes 10.2 IL10 IL4 TLR9
46 penicillin allergy 10.2 IL10 IL13 IL4
47 churg-strauss syndrome 10.2 IL10 IL5 RNASE3
48 chronic meningitis 10.2 CCL11 IL5
49 keratoconjunctivitis sicca 10.2 IL10 IL4 TLR9
50 beta-lactam allergy 10.2 IL10 IL13 IL4

Graphical network of the top 20 diseases related to Nasal Cavity Disease:



Diseases related to Nasal Cavity Disease

Symptoms & Phenotypes for Nasal Cavity Disease

MGI Mouse Phenotypes related to Nasal Cavity Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 CCL11 CHD7 HRH1 ICAM1 IL10 IL13
2 homeostasis/metabolism MP:0005376 10.1 CHD7 HRH1 ICAM1 IL10 IL13 IL33
3 immune system MP:0005387 10.03 CCL11 CHD7 CYSLTR1 HRH1 ICAM1 IL10
4 digestive/alimentary MP:0005381 10.02 CHD7 ICAM1 IL10 IL13 IL33 IL4
5 integument MP:0010771 9.56 ICAM1 IL10 IL13 IL33 IL4 TAC1
6 respiratory system MP:0005388 9.28 CCL11 CHD7 CYSLTR1 IL10 IL13 IL33

Drugs & Therapeutics for Nasal Cavity Disease

Search Clinical Trials , NIH Clinical Center for Nasal Cavity Disease

Genetic Tests for Nasal Cavity Disease

Anatomical Context for Nasal Cavity Disease

MalaCards organs/tissues related to Nasal Cavity Disease:

41
Lung, Skin, Bone, Eye, Salivary Gland

Publications for Nasal Cavity Disease

Variations for Nasal Cavity Disease

Expression for Nasal Cavity Disease

Search GEO for disease gene expression data for Nasal Cavity Disease.

Pathways for Nasal Cavity Disease

Pathways related to Nasal Cavity Disease according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 CCL11 ICAM1 IL10 IL13 IL33 IL4
2
Show member pathways
12.71 CCL11 ICAM1 IL10 IL13 IL4 IL5
3
Show member pathways
12.68 ICAM1 IL13 IL33 IL4 TLR9
4
Show member pathways
12.32 IL10 IL13 IL4 IL5 TSLP
5
Show member pathways
12.22 CCL11 IL13 IL4 IL5
6
Show member pathways
11.98 CCL11 ICAM1 IL10 IL13 IL4 IL5
7 11.91 IL10 IL4 IL5 PTGDR2
8 11.86 CCL11 ICAM1 IL10 IL13 IL4
9 11.75 ICAM1 IL13 IL4 IL5
10 11.66 CCL11 IL10 IL13 IL4
11 11.58 CCL11 IL10 IL4 IL5
12 11.56 CCL11 IL13 IL4 IL5
13 11.44 ICAM1 IL10 TLR9
14 11.42 ICAM1 IL10 IL13 IL4
15 11.29 ICAM1 IL10 TLR9
16 11.15 CCL11 IL10 IL13 IL4 IL5
17 11.1 CCL11 IL10 IL13 IL33 IL4 IL5
18 11.09 IL10 IL13 IL4 IL5
19 11.07 IL10 IL13 IL33 IL4 IL5 PTGDR2
20 11.06 IL13 IL33 IL4 IL5 TSLP
21 10.97 IL10 IL13 IL4 IL5
22 10.91 CCL11 IL10 IL13 IL4 IL5

GO Terms for Nasal Cavity Disease

Cellular components related to Nasal Cavity Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 CCL11 IL10 IL13 IL33 IL4 IL5
2 extracellular space GO:0005615 9.32 CCL11 ICAM1 IL10 IL13 IL33 IL4

Biological processes related to Nasal Cavity Disease according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.88 CCL11 ICAM1 IL10 IL13 IL4 IL5
2 regulation of signaling receptor activity GO:0010469 9.87 CCL11 IL10 IL13 IL33 IL4 IL5
3 response to lipopolysaccharide GO:0032496 9.81 ICAM1 IL10 IL13 TAC1
4 neuropeptide signaling pathway GO:0007218 9.79 CYSLTR1 PTGDR2 TAC1
5 positive regulation of inflammatory response GO:0050729 9.77 IL33 TLR9 TSLP
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.75 IL13 IL4 TSLP
7 positive regulation of interleukin-6 production GO:0032755 9.72 IL33 TLR9 TSLP
8 positive regulation of immunoglobulin secretion GO:0051024 9.61 IL33 IL5
9 positive regulation of macrophage activation GO:0043032 9.61 IL10 IL13 IL33
10 response to molecule of bacterial origin GO:0002237 9.6 IL10 TLR9
11 cellular response to alkaloid GO:0071312 9.58 ICAM1 TRPV1
12 positive regulation of immunoglobulin production GO:0002639 9.57 IL13 TLR9
13 positive regulation of interleukin-5 production GO:0032754 9.56 IL33 TSLP
14 positive regulation of B cell proliferation GO:0030890 9.56 IL13 IL4 IL5 TLR9
15 immune response GO:0006955 9.56 CCL11 IL10 IL13 IL4 IL5 MS4A2
16 negative regulation of interleukin-8 production GO:0032717 9.54 IL10 TLR9
17 positive regulation of interleukin-13 production GO:0032736 9.54 IL33 IL4 TSLP
18 positive regulation of MHC class II biosynthetic process GO:0045348 9.52 IL10 IL4
19 regulation of isotype switching GO:0045191 9.49 IL10 IL4
20 type 2 immune response GO:0042092 9.48 IL10 IL4
21 negative regulation of complement-dependent cytotoxicity GO:1903660 9.46 IL13 IL4
22 negative regulation of endothelial cell apoptotic process GO:2000352 9.46 ICAM1 IL10 IL13 IL4
23 inflammatory response GO:0006954 9.28 CCL11 HRH1 IL10 IL13 IL5 MS4A2

Molecular functions related to Nasal Cavity Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CCL11 IL10 IL13 IL33 IL4 IL5

Sources for Nasal Cavity Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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