MCID: NSL004
MIFTS: 31

Nasal Cavity Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases, Respiratory diseases

Aliases & Classifications for Nasal Cavity Lymphoma

MalaCards integrated aliases for Nasal Cavity Lymphoma:

Name: Nasal Cavity Lymphoma 12 15 70
Lymphoma of the Nasal Cavity 12
Lymphoma of Nasal Cavity 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10813
NCIt 50 C6074
UMLS 70 C1334921

Summaries for Nasal Cavity Lymphoma

MalaCards based summary : Nasal Cavity Lymphoma, also known as lymphoma of the nasal cavity, is related to follicular lymphoma and b-cell lymphoma. An important gene associated with Nasal Cavity Lymphoma is NCAM1 (Neural Cell Adhesion Molecule 1), and among its related pathways/superpathways are NF-kappaB Signaling and Hematopoietic cell lineage. The drugs Dexamethasone and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and bone.

Related Diseases for Nasal Cavity Lymphoma

Diseases related to Nasal Cavity Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 follicular lymphoma 30.1 MME CD5 BCL6
2 b-cell lymphoma 30.0 TIA1 MME CDKN2A CD5 BCL6
3 diffuse large b-cell lymphoma 29.9 MME CDKN2A CD5 BCL6 B2M
4 lymphoma, hodgkin, classic 29.8 TIA1 GZMB BCL6
5 lymphoproliferative syndrome 29.4 TIA1 PRF1 CD5 BCL6
6 mature t-cell and nk-cell lymphoma 28.7 TIA1 NCAM1 MME GZMB CD5 CD2
7 lymphoma 28.4 TIA1 PRF1 GZMB CDKN2A CD5 BCL6
8 lymphoma, non-hodgkin, familial 27.9 PRF1 NCAM1 MME IGHV4-38-2 GZMB CD5
9 solitary osseous plasmacytoma 10.3 NCAM1 B2M
10 infected hydrocele 10.3 NCAM1 B2M
11 papillary thymic adenocarcinoma 10.3 NCAM1 CD5
12 orbit lymphoma 10.3 TIA1 NCAM1
13 laryngeal small cell carcinoma 10.3 NCAM1 CDKN2A
14 mediastinal cancer 10.3 NCAM1 CD5
15 lymphohistiocytoid mesothelioma 10.2 CDKN2A CD5
16 nasal cavity benign neoplasm 10.2 NCAM1 CD2
17 bile duct adenoma 10.2 NCAM1 CDKN2A
18 parapsoriasis 10.2 CD5 CD2
19 rhinosporidiosis 10.2 TIA1 NCAM1
20 dermatitis, atopic, 5 10.2 NCAM1 CD5
21 follicular mucinosis 10.2 CD5 CD2
22 lung combined type small cell carcinoma 10.2 NCAM1 MME
23 parasitic ichthyosporea infectious disease 10.2 TIA1 NCAM1
24 pancreatic serous cystadenocarcinoma 10.2 NCAM1 MME
25 orbital cellulitis 10.2 NCAM1 MME
26 acute orbital inflammation 10.2 NCAM1 MME
27 vulvar leiomyoma 10.2 NCAM1 MME
28 thyrotoxic exophthalmos 10.2 MME CD5
29 endocrine exophthalmos 10.2 MME CD5
30 nasal cavity olfactory neuroblastoma 10.2 NCAM1 MME
31 alpha chain disease 10.2 CD5 BCL6
32 lymphomatoid granulomatosis 10.2 TIA1 GZMB
33 breast lipoma 10.2 TIA1 GZMB
34 primary cutaneous anaplastic large cell lymphoma 10.2 TIA1 GZMB
35 lichen sclerosus et atrophicus 10.2 TIA1 GZMB
36 sclerosing hepatic carcinoma 10.2 MME CD5
37 cutaneous adenocystic carcinoma 10.2 MME B2M
38 hepatosplenic t-cell lymphoma 10.2 TIA1 GZMB
39 monoclonal paraproteinemia 10.2 NCAM1 IGHV4-38-2
40 plasmablastic lymphoma 10.1 CDKN2A BCL6
41 lymphocytic gastritis 10.1 TIA1 GZMB
42 intrahepatic bile duct adenoma 10.1 NCAM1 MME
43 primary cutaneous b-cell lymphoma 10.1 CDKN2A BCL6
44 inflammatory liposarcoma 10.1 MME CDKN2A
45 lymphomatoid papulosis 10.1 TIA1 GZMB
46 soft palate cancer 10.1 CDKN2A BCL6
47 dacryocystocele 10.1 NCAM1 IGHV4-38-2
48 chronic inflammation of lacrimal passage 10.1 NCAM1 IGHV4-38-2
49 atypical polypoid adenomyoma 10.1 MME CDKN2A
50 adenomyoma 10.1 MME CDKN2A

Graphical network of the top 20 diseases related to Nasal Cavity Lymphoma:



Diseases related to Nasal Cavity Lymphoma

Symptoms & Phenotypes for Nasal Cavity Lymphoma

Drugs & Therapeutics for Nasal Cavity Lymphoma

Drugs for Nasal Cavity Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
3
Ifosfamide Approved Phase 2 3778-73-2 3690
4
Etoposide Approved Phase 2 33419-42-0 36462
5
Pembrolizumab Approved Phase 2 1374853-91-4
6
Isophosphamide mustard Phase 2 100427
7 Etoposide phosphate Phase 2
8
asparaginase Phase 2
9 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Open-labeled, Multicenter Phase II Study of Concomitant Chemo-radiotherapy Followed by VIDL Chemotherapy With Risk-based Application of Autologous Stem Cell Transplantation in Stage I/II Extranodal NK/T-cell Lymphoma Completed NCT01007526 Phase 2
2 Pilot Study of Pembrolizumab in Untreated Extranodal, NK/T Cell Lymphoma, Nasal Type Recruiting NCT03728972 Phase 2 Pembrolizumab

Search NIH Clinical Center for Nasal Cavity Lymphoma

Genetic Tests for Nasal Cavity Lymphoma

Anatomical Context for Nasal Cavity Lymphoma

MalaCards organs/tissues related to Nasal Cavity Lymphoma:

40
Lung, Breast, Bone, Bone Marrow, Eye, Spleen, Heart

Publications for Nasal Cavity Lymphoma

Articles related to Nasal Cavity Lymphoma:

(show all 46)
# Title Authors PMID Year
1
NK/T-cell lymphoma of the nasal cavity: an unexpected diagnosis. 61
33762288 2021
2
Identification of A Novel Papillomavirus Associated with Squamous Cell Carcinoma in A Domestic Cat. 61
31968684 2020
3
Extranodal natural killer/T-cell lymphoma nasal type with central nervous system involvement mimicked tuberculous meningitis: A case report. 61
31441847 2019
4
[Clinical differences between primary nasopharyngeal NK/T-cell lymphoma and primary nasal cavity NK/T-cell lymphoma with nasopharynx extension]. 61
30678418 2019
5
Extranodal NK/T-cell lymphoma of the nasal cavity developed in a patient with intestinal Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorder. 61
29843925 2018
6
Lymphoma of the nasal cavity and paranasal sinuses: A case series. 61
27657899 2016
7
Nasal dissemination of a single-clone IgH-rearranged conjunctival MALT lymphoma through the nasolacrimal duct: A case report. 61
27446385 2016
8
T-cell lymphoma in the nasal cavity of a Brown Swiss heifer. 61
25886837 2015
9
Sinonasal lymphoma: case series and review of the literature. 61
24760602 2014
10
[Radiation therapy of sinonasal natural killer/T-cell lymphoma]. 61
24462054 2014
11
Diffuse large B-cell lymphoma of the nasal cavity presenting as abducens nerve palsy. 61
24220442 2013
12
[Clinical analysis of 20 patients with primary non-Hodgkin's lymphoma of nasal cavity and nasopharynx]. 61
24459928 2013
13
NK/T-cell lymphoma of the nasal cavity causing contralateral dacryoadenitis. 61
23663138 2013
14
Pathology in practice. Nonepitheliotropic B-cell lymphoma of the nasal cavity with associated suppurative rhinitis and epidermal ulceration and lymphoma of the right kidney. 61
22380803 2012
15
The simultaneous appearance of a nasal natural killer-cell lymphoma and acute myelogenous leukemia. 61
22545391 2012
16
Aggressive sinonasal natural killer/T-cell lymphoma with hemophagocytic lymphohistiocytosis. 61
21764176 2012
17
Combined chemoradiation for the management of nasal natural killer (NK)/T-cell lymphoma: elucidating the significance of systemic chemotherapy. 61
17306611 2008
18
[Primary non-Hodgkin's lymphoma of the nasal cavity at early stage: long-term treatment outcomes and prognostic analyses of 108 cases]. 61
17166382 2006
19
EBV-associated nasal-type NK/T-cell lymphoma of the nasal cavity/paranasal sinus in a renal allograft recipient. 61
16364984 2006
20
[Prognostic factors of primary non-Hodgkin's lymphoma of the nasal cavity--a report of 129 cases]. 61
16613682 2006
21
[Treatment option and outcome for patients with primary non-Hodgkin's lymphoma of the nasal cavity]. 61
16737624 2006
22
[Angiocentric lymphoma of the face: report of the 2 cases]. 61
14522352 2003
23
Mortality among chrome leather tannery workers: an update. 61
12874853 2003
24
Lymphoma of the nasal cavity and paranasal sinuses: treatment and outcome of early-stage disease. 61
12576916 2003
25
[Lymphoma of the nasal cavity, clinical and anatomo-pathologic considerations]. 61
12733318 2003
26
Primary non-Hodgkin's lymphoma of the nose and paranasal sinuses: a case report. 61
15027735 2003
27
Localized aggressive non-Hodgkin's lymphoma of the nasal cavity: a survey by the Japan Lymphoma Radiation Therapy Group. 61
11728681 2001
28
[Natural killer cell nasal lymphoma mimicking localized Wegener's disease]. 61
11433567 2001
29
[Multivariate analysis of prognosis of patients with stage IE non-Hodgkin's lymphomas of the nasal cavity]. 61
11783097 2001
30
[A rare case of malignant lymphoma of the nasal cavity and paranasal sinuses]. 61
11494739 2001
31
Angiocentric nasal T/natural killer cell lymphoma: a single centre study of prognostic factors in 108 patients. 61
11012633 2000
32
Primary non-Hodgkin's lymphoma of the nasal cavity. Clinical case report and discussion. 61
10958410 2000
33
Primary non-Hodgkin's lymphoma of the nasal cavity: prognostic significance of paranasal extension and the role of radiotherapy and chemotherapy. 61
9690537 1998
34
Lymphoma of the nasal cavity and paranasal sinuses: improved outcome and altered prognostic factors with combined modality therapy. 61
9241082 1997
35
Clinical stage IE primary lymphoma of the nasal cavity: radiation therapy and chemotherapy. 61
9240537 1997
36
[A clinical and pathological study of non-Hodgkin's lymphoma of the nasal cavity and paranasal sinuses]. 61
8337110 1993
37
[Non-Hodgkin's lymphoma of the nasal cavity and paranasal sinuses: clinicopathologic study of ten cases]. 61
1890745 1991
38
[A clinical study of non-Hodgkin's lymphoma of the nasal cavity and paranasal sinus]. 61
3249114 1988
39
Primary lymphoma of the nasal cavity. A case report. 61
3616212 1987
40
[Radiotherapy of non-Hodgkin's lymphoma of the nasal cavity--report of 48 cases]. 61
3915458 1985
41
A comparative analysis of lymphomas involving Waldeyer's ring and the nasal cavity and paranasal sinuses. 61
4068097 1985
42
[Malignant lymphoma of the nasal cavity]. 61
6515888 1984
43
Computed tomography of sinonasal non-Hodgkin lymphoma. 61
6707267 1984
44
[Lymphoma of the nasal cavity. Review of 62 cases]. 61
6718825 1984
45
[Light and electron microscopic observation on malignant lymphoma of the nasal cavity--a case report]. 61
6745058 1984
46
Diagnosis of malignant lymphomas of the nasal cavity, paranasal sinuses and nasopharynx. 61
6621224 1983

Variations for Nasal Cavity Lymphoma

Expression for Nasal Cavity Lymphoma

Search GEO for disease gene expression data for Nasal Cavity Lymphoma.

Pathways for Nasal Cavity Lymphoma

Pathways related to Nasal Cavity Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.87 NCAM1 GZMB CD2 BCL6 B2M
2 11.43 MME CD5 CD2
3
Show member pathways
11.12 PRF1 GZMB B2M
4 10.99 NCAM1 MME CD5 CD2
5 10.83 ERF CDKN2A

GO Terms for Nasal Cavity Lymphoma

Cellular components related to Nasal Cavity Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.02 NCAM1 IGHV4-38-2 CD5 CD2 B2M

Biological processes related to Nasal Cavity Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytolysis GO:0019835 9.37 PRF1 GZMB
2 negative regulation of cell-matrix adhesion GO:0001953 9.32 CDKN2A BCL6
3 positive regulation of cellular senescence GO:2000774 9.26 CDKN2A B2M
4 replicative senescence GO:0090399 9.16 MME CDKN2A
5 apoptotic process GO:0006915 9.1 TIA1 PRF1 NISCH GZMB CDKN2A CD2
6 amyloid fibril formation GO:1990000 8.96 CDKN2A B2M

Molecular functions related to Nasal Cavity Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.1 PRF1 NISCH NCAM1 CD2 BCL6 B2M

Sources for Nasal Cavity Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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