MCID: NSL004
MIFTS: 32

Nasal Cavity Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases, Respiratory diseases

Aliases & Classifications for Nasal Cavity Lymphoma

MalaCards integrated aliases for Nasal Cavity Lymphoma:

Name: Nasal Cavity Lymphoma 12 15 71
Lymphoma of the Nasal Cavity 12
Lymphoma of Nasal Cavity 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10813
NCIt 49 C6074
UMLS 71 C1334921

Summaries for Nasal Cavity Lymphoma

MalaCards based summary : Nasal Cavity Lymphoma, also known as lymphoma of the nasal cavity, is related to b-cell lymphoma and diffuse large b-cell lymphoma. An important gene associated with Nasal Cavity Lymphoma is SCYL1 (SCY1 Like Pseudokinase 1), and among its related pathways/superpathways are NF-kappaB Signaling and Hematopoietic Stem Cells and Lineage-specific Markers. The drugs Etoposide and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and kidney, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Nasal Cavity Lymphoma

Diseases related to Nasal Cavity Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 b-cell lymphoma 30.2 TIA1 CDKN2A CD5 BCL6
2 diffuse large b-cell lymphoma 30.0 CDKN2A CD5 BCL6 B2M
3 lymphoblastic lymphoma 29.8 CDKN2A CD5 BCL6
4 lymphoma, hodgkin, classic 29.4 TIA1 GZMB BCL6
5 lymphoma 29.1 TIA1 GZMB CDKN2A CD5 BCL6 B2M
6 lymphoma, non-hodgkin, familial 26.8 PRF1 NCAM1 IGHV4-38-2 GZMB CDKN2A CD5
7 solitary osseous plasmacytoma 10.4 NCAM1 B2M
8 orbit lymphoma 10.4 TIA1 NCAM1
9 papillary thymic adenocarcinoma 10.4 NCAM1 CD5
10 infected hydrocele 10.4 NCAM1 B2M
11 soft palate cancer 10.4 CDKN2A B2M
12 laryngeal small cell carcinoma 10.4 NCAM1 CDKN2A
13 cranial nerve neoplasm 10.3 SCRT1 NCAM1
14 mediastinal cancer 10.3 NCAM1 CD5
15 extramedullary plasmacytoma 10.3 NCAM1 B2M
16 bile duct adenoma 10.3 NCAM1 CDKN2A
17 chronic dacryoadenitis 10.3 SCYL1 IGHV4-38-2
18 paranasal sinus lymphoma 10.3 SCYL1 BCL6
19 retina lymphoma 10.3 SCYL1 IGHV4-38-2
20 parapsoriasis 10.3 CD5 CD2
21 lymphohistiocytoid mesothelioma 10.3 CDKN2A CD5
22 bladder lymphoma 10.2 CD5 BCL6
23 monoclonal paraproteinemia 10.2 NCAM1 IGHV4-38-2
24 prostate lymphoma 10.2 CD5 BCL6
25 epiglottis neoplasm 10.2 CD5 BCL6
26 lung lymphoma 10.2 CD5 BCL6
27 bone lymphoma 10.2 CD5 BCL6
28 colon lymphoma 10.2 CD5 BCL6
29 appendix lymphoma 10.2 CD5 BCL6
30 lymphomatoid granulomatosis 10.2 TIA1 GZMB
31 breast lipoma 10.2 TIA1 GZMB
32 primary cutaneous anaplastic large cell lymphoma 10.2 TIA1 GZMB
33 adult lymphoma 10.2 CD5 BCL6
34 lichen sclerosus et atrophicus 10.1 TIA1 GZMB
35 hepatosplenic t-cell lymphoma 10.1 TIA1 GZMB
36 plasmablastic lymphoma 10.1 CDKN2A BCL6
37 primary cutaneous b-cell lymphoma 10.1 CDKN2A BCL6
38 gastrointestinal lymphoma 10.1 NCAM1 CD5 BCL6
39 lymphocytic gastritis 10.1 TIA1 GZMB
40 lymphomatoid papulosis 10.1 TIA1 GZMB
41 t-cell adult acute lymphocytic leukemia 10.1 TIA1 CD5 CD2
42 t-cell lymphoma, subcutaneous panniculitis-like 10.1 TIA1 GZMB
43 non-secretory myeloma 10.1 NCAM1 IGHV4-38-2 B2M
44 intravascular large b-cell lymphoma 10.1 CD5 BCL6 B2M
45 smoldering myeloma 10.1 NCAM1 IGHV4-38-2 B2M
46 chest wall lymphoma 10.1 IGHV4-38-2 BCL6
47 follicular lymphoma 10.1
48 rhinitis 10.1
49 monoclonal gammopathy of uncertain significance 10.1 NCAM1 IGHV4-38-2 B2M
50 blood protein disease 10.1 NCAM1 IGHV4-38-2 B2M

Graphical network of the top 20 diseases related to Nasal Cavity Lymphoma:



Diseases related to Nasal Cavity Lymphoma

Symptoms & Phenotypes for Nasal Cavity Lymphoma

GenomeRNAi Phenotypes related to Nasal Cavity Lymphoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.32 CD2 CDKN2A GZMB PSMB8 TCOF1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.32 CD2 CDKN2A GZMB PSMB8 TCOF1

MGI Mouse Phenotypes related to Nasal Cavity Lymphoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.32 ANKRD11 B2M BCL6 CD5 CDKN2A ERF

Drugs & Therapeutics for Nasal Cavity Lymphoma

Drugs for Nasal Cavity Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 2 33419-42-0 36462
2
Ifosfamide Approved Phase 2 3778-73-2 3690
3
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
4
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
5
Pembrolizumab Approved Phase 2 1374853-91-4
6 Etoposide phosphate Phase 2
7
Isophosphamide mustard Phase 2 0
8
asparaginase Phase 2
9 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Open-labeled, Multicenter Phase II Study of Concomitant Chemo-radiotherapy Followed by VIDL Chemotherapy With Risk-based Application of Autologous Stem Cell Transplantation in Stage I/II Extranodal NK/T-cell Lymphoma Completed NCT01007526 Phase 2
2 Pilot Study of Pembrolizumab in Untreated Extranodal, NK/T Cell Lymphoma, Nasal Type Recruiting NCT03728972 Phase 2 Pembrolizumab

Search NIH Clinical Center for Nasal Cavity Lymphoma

Genetic Tests for Nasal Cavity Lymphoma

Anatomical Context for Nasal Cavity Lymphoma

MalaCards organs/tissues related to Nasal Cavity Lymphoma:

40
T Cells, B Cells, Kidney, Nk Cells

Publications for Nasal Cavity Lymphoma

Articles related to Nasal Cavity Lymphoma:

(show all 45)
# Title Authors PMID Year
1
Identification of A Novel Papillomavirus Associated with Squamous Cell Carcinoma in A Domestic Cat. 61
31968684 2020
2
Extranodal natural killer/T-cell lymphoma nasal type with central nervous system involvement mimicked tuberculous meningitis: A case report. 61
31441847 2019
3
[Clinical differences between primary nasopharyngeal NK/T-cell lymphoma and primary nasal cavity NK/T-cell lymphoma with nasopharynx extension]. 61
30678418 2019
4
Extranodal NK/T-cell lymphoma of the nasal cavity developed in a patient with intestinal Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorder. 61
29843925 2018
5
Lymphoma of the nasal cavity and paranasal sinuses: A case series. 61
27657899 2016
6
Nasal dissemination of a single-clone IgH-rearranged conjunctival MALT lymphoma through the nasolacrimal duct: A case report. 61
27446385 2016
7
T-cell lymphoma in the nasal cavity of a Brown Swiss heifer. 61
25886837 2015
8
Sinonasal lymphoma: case series and review of the literature. 61
24760602 2014
9
[Radiation therapy of sinonasal natural killer/T-cell lymphoma]. 61
24462054 2014
10
Diffuse large B-cell lymphoma of the nasal cavity presenting as abducens nerve palsy. 61
24220442 2013
11
[Clinical analysis of 20 patients with primary non-Hodgkin's lymphoma of nasal cavity and nasopharynx]. 61
24459928 2013
12
NK/T-cell lymphoma of the nasal cavity causing contralateral dacryoadenitis. 61
23663138 2013
13
Pathology in practice. Nonepitheliotropic B-cell lymphoma of the nasal cavity with associated suppurative rhinitis and epidermal ulceration and lymphoma of the right kidney. 61
22380803 2012
14
Aggressive sinonasal natural killer/T-cell lymphoma with hemophagocytic lymphohistiocytosis. 61
21764176 2012
15
The simultaneous appearance of a nasal natural killer-cell lymphoma and acute myelogenous leukemia. 61
22545391 2012
16
Combined chemoradiation for the management of nasal natural killer (NK)/T-cell lymphoma: elucidating the significance of systemic chemotherapy. 61
17306611 2008
17
[Primary non-Hodgkin's lymphoma of the nasal cavity at early stage: long-term treatment outcomes and prognostic analyses of 108 cases]. 61
17166382 2006
18
EBV-associated nasal-type NK/T-cell lymphoma of the nasal cavity/paranasal sinus in a renal allograft recipient. 61
16364984 2006
19
[Prognostic factors of primary non-Hodgkin's lymphoma of the nasal cavity--a report of 129 cases]. 61
16613682 2006
20
[Treatment option and outcome for patients with primary non-Hodgkin's lymphoma of the nasal cavity]. 61
16737624 2006
21
[Angiocentric lymphoma of the face: report of the 2 cases]. 61
14522352 2003
22
Mortality among chrome leather tannery workers: an update. 61
12874853 2003
23
Lymphoma of the nasal cavity and paranasal sinuses: treatment and outcome of early-stage disease. 61
12576916 2003
24
[Lymphoma of the nasal cavity, clinical and anatomo-pathologic considerations]. 61
12733318 2003
25
Primary non-Hodgkin's lymphoma of the nose and paranasal sinuses: a case report. 61
15027735 2003
26
Localized aggressive non-Hodgkin's lymphoma of the nasal cavity: a survey by the Japan Lymphoma Radiation Therapy Group. 61
11728681 2001
27
[Natural killer cell nasal lymphoma mimicking localized Wegener's disease]. 61
11433567 2001
28
[Multivariate analysis of prognosis of patients with stage IE non-Hodgkin's lymphomas of the nasal cavity]. 61
11783097 2001
29
[A rare case of malignant lymphoma of the nasal cavity and paranasal sinuses]. 61
11494739 2001
30
Angiocentric nasal T/natural killer cell lymphoma: a single centre study of prognostic factors in 108 patients. 61
11012633 2000
31
Primary non-Hodgkin's lymphoma of the nasal cavity. Clinical case report and discussion. 61
10958410 2000
32
Primary non-Hodgkin's lymphoma of the nasal cavity: prognostic significance of paranasal extension and the role of radiotherapy and chemotherapy. 61
9690537 1998
33
Clinical stage IE primary lymphoma of the nasal cavity: radiation therapy and chemotherapy. 61
9240537 1997
34
Lymphoma of the nasal cavity and paranasal sinuses: improved outcome and altered prognostic factors with combined modality therapy. 61
9241082 1997
35
[A clinical and pathological study of non-Hodgkin's lymphoma of the nasal cavity and paranasal sinuses]. 61
8337110 1993
36
[Non-Hodgkin's lymphoma of the nasal cavity and paranasal sinuses: clinicopathologic study of ten cases]. 61
1890745 1991
37
[A clinical study of non-Hodgkin's lymphoma of the nasal cavity and paranasal sinus]. 61
3249114 1988
38
Primary lymphoma of the nasal cavity. A case report. 61
3616212 1987
39
[Radiotherapy of non-Hodgkin's lymphoma of the nasal cavity--report of 48 cases]. 61
3915458 1985
40
A comparative analysis of lymphomas involving Waldeyer's ring and the nasal cavity and paranasal sinuses. 61
4068097 1985
41
[Malignant lymphoma of the nasal cavity]. 61
6515888 1984
42
Computed tomography of sinonasal non-Hodgkin lymphoma. 61
6707267 1984
43
[Lymphoma of the nasal cavity. Review of 62 cases]. 61
6718825 1984
44
[Light and electron microscopic observation on malignant lymphoma of the nasal cavity--a case report]. 61
6745058 1984
45
Diagnosis of malignant lymphomas of the nasal cavity, paranasal sinuses and nasopharynx. 61
6621224 1983

Variations for Nasal Cavity Lymphoma

Expression for Nasal Cavity Lymphoma

Search GEO for disease gene expression data for Nasal Cavity Lymphoma.

Pathways for Nasal Cavity Lymphoma

Pathways related to Nasal Cavity Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.61 PSMB8 NCAM1 GZMB CD2 BCL6 B2M
2 11.4 NCAM1 CD5 CD2
3
Show member pathways
10.92 PRF1 GZMB B2M

GO Terms for Nasal Cavity Lymphoma

Cellular components related to Nasal Cavity Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.73 TIA1 TCOF1 SCYL1 PSMB8 PRF1 NISCH
2 external side of plasma membrane GO:0009897 9.02 NCAM1 IGHV4-38-2 CD5 CD2 B2M

Biological processes related to Nasal Cavity Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell-matrix adhesion GO:0001953 9.32 CDKN2A BCL6
2 positive regulation of cellular senescence GO:2000774 9.26 CDKN2A B2M
3 cytolysis GO:0019835 9.16 PRF1 GZMB
4 apoptotic process GO:0006915 9.1 TIA1 PRF1 NISCH GZMB CDKN2A CD2
5 amyloid fibril formation GO:1990000 8.96 CDKN2A B2M

Sources for Nasal Cavity Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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