MCID: NSL006
MIFTS: 40

Nasal Cavity Squamous Cell Carcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Nasal Cavity Squamous Cell Carcinoma

MalaCards integrated aliases for Nasal Cavity Squamous Cell Carcinoma:

Name: Nasal Cavity Squamous Cell Carcinoma 12 15 17 74
Squamous Cell Carcinoma of the Nasal Cavity 12
Squamous Cell Carcinoma of Nasal Cavity 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5515
NCIt 51 C8192
UMLS 74 C0280333

Summaries for Nasal Cavity Squamous Cell Carcinoma

Disease Ontology : 12 A nasal cavity carcinoma that has material basis in squamous cells.

MalaCards based summary : Nasal Cavity Squamous Cell Carcinoma, also known as squamous cell carcinoma of the nasal cavity, is related to squamous cell carcinoma, head and neck and papilloma, and has symptoms including pain and rhinorrhea. An important gene associated with Nasal Cavity Squamous Cell Carcinoma is MMP2 (Matrix Metallopeptidase 2), and among its related pathways/superpathways are Degradation of the extracellular matrix and Interleukin-4 and 13 signaling. The drugs Raspberry and Cola have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and lymph node, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Nasal Cavity Squamous Cell Carcinoma

Diseases related to Nasal Cavity Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma, head and neck 32.5 CDKN2A MMP2 MMP9 TIMP2
2 papilloma 29.9 CDKN2A KRT5 KRT7 KRT8
3 extracranial arteriovenous malformation 10.5 MMP2 MMP9
4 focal myositis 10.5 MMP2 MMP9
5 villous adenocarcinoma 10.5 MMP2 MMP9
6 spastic entropion 10.5 MMP2 MMP9
7 psammomatous meningioma 10.4 MMP2 MMP9
8 acute transverse myelitis 10.4 MMP2 MMP9
9 senile ectropion 10.4 MMP2 MMP9
10 internal hemorrhoid 10.4 MMP2 MMP9
11 anal fistula 10.4 KIDINS220 MMP9
12 ischemic colitis 10.4 MMP2 MMP9
13 light chain deposition disease 10.4 MMP2 MMP9
14 squamous cell carcinoma 10.4
15 parotitis 10.4 MMP2 MMP9
16 klatskin's tumor 10.4 MMP2 MMP9
17 gingival hypertrophy 10.4 MMP9 TIMP2
18 vulvar intraepithelial neoplasia 10.4 KRT7 MMP2
19 autoimmune inner ear disease 10.4 MMP9 TIMP1
20 proliferating trichilemmal cyst 10.4 KRT7 KRT8
21 endolymphatic sac tumor 10.3 KRT7 KRT8
22 benign breast adenomyoepithelioma 10.3 KRT5 KRT7
23 breast adenomyoepithelioma 10.3 KRT5 KRT7
24 ceruminoma 10.3 KRT5 KRT7
25 malignant spiradenoma 10.3 KRT5 KRT7
26 hidrocystoma 10.3 KRT7 KRT8
27 benign mesothelioma 10.3 KRT5 KRT7
28 sensory organ benign neoplasm 10.3 KRT5 KRT7
29 cutaneous adenocystic carcinoma 10.3 KRT7 KRT8
30 bile duct mucoepidermoid carcinoma 10.3 KRT5 KRT7
31 adenoid squamous cell carcinoma 10.3 KRT7 KRT8
32 middle ear adenoma 10.3 KRT5 KRT7
33 corneal ulcer 10.3 MMP2 MMP9
34 cryptogenic organizing pneumonia 10.3 MMP9 TIMP1
35 cervical clear cell adenocarcinoma 10.3 KRT5 KRT8
36 odontoma 10.3 KRT5 KRT8
37 brooke-spiegler syndrome 10.3 KRT7 KRT8
38 adenomyosis 10.3 MMP2 MMP9 TIMP2
39 malignant biphasic mesothelioma 10.3 KRT5 KRT7
40 optic nerve sheath meningioma 10.2 CDKN2A KRT5
41 peritoneum cancer 10.2 KRT5 KRT7
42 keratinizing squamous cell carcinoma 10.2 CDKN2A KRT5
43 periodontitis 10.2 MMP2 MMP9 TIMP1
44 urethral diverticulum 10.2 KIDINS220 KRT7
45 pleomorphic carcinoma 10.2 KRT7 KRT8
46 gastric squamous cell carcinoma 10.2 KRT5 KRT7
47 lymphoepithelioma-like thymic carcinoma 10.2 CDKN2A KRT5
48 microcystic meningioma 10.2 MMP2 TIMP1 TIMP2
49 mucinous tubular and spindle renal cell carcinoma 10.2 KRT7 KRT8
50 lentigo maligna melanoma 10.2 MLANA MMP2 MMP9

Graphical network of the top 20 diseases related to Nasal Cavity Squamous Cell Carcinoma:



Diseases related to Nasal Cavity Squamous Cell Carcinoma

Symptoms & Phenotypes for Nasal Cavity Squamous Cell Carcinoma

UMLS symptoms related to Nasal Cavity Squamous Cell Carcinoma:


pain, rhinorrhea

GenomeRNAi Phenotypes related to Nasal Cavity Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.44 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.44 KRT5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.44 KRT5 KRT8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.44 KRT5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.44 KRT8
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.44 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.44 KRT5 KRT7 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.44 KRT7
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.44 KRT5 KRT7

MGI Mouse Phenotypes related to Nasal Cavity Squamous Cell Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.76 CDKN2A FRS2 KIDINS220 KRT8 MMP2 MMP9
2 growth/size/body region MP:0005378 9.65 ANKRD11 CDKN2A FRS2 KIDINS220 KRT5 KRT8
3 mortality/aging MP:0010768 9.32 ANKRD11 CDKN2A FRS2 KIDINS220 KRT5 KRT8

Drugs & Therapeutics for Nasal Cavity Squamous Cell Carcinoma

Drugs for Nasal Cavity Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Raspberry Approved Phase 1, Phase 2
2 Cola Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 1b Food Based Modulation of Biomarkers in Human Tissues at High-Risk for Oral Cancer. Completed NCT01469429 Phase 1, Phase 2 chemoprevention;chemoprevention
2 ONYX-015 With Cisplatin and Fluorouracil in Treating Patients With Advanced Head and Neck Cancer Withdrawn NCT00006106 Phase 1 cisplatin;fluorouracil;ONYX-015
3 Questionnaire in Screening Older Patients With Cancer Completed NCT00963911 Not Applicable

Search NIH Clinical Center for Nasal Cavity Squamous Cell Carcinoma

Genetic Tests for Nasal Cavity Squamous Cell Carcinoma

Anatomical Context for Nasal Cavity Squamous Cell Carcinoma

MalaCards organs/tissues related to Nasal Cavity Squamous Cell Carcinoma:

42
Skin, Tongue, Lymph Node, Bone, Prostate, Tonsil

Publications for Nasal Cavity Squamous Cell Carcinoma

Articles related to Nasal Cavity Squamous Cell Carcinoma:

(show all 18)
# Title Authors Year
1
Organ preservation for patients with anterior mucosal squamous cell carcinoma of the nasal cavity: Rhinectomy-free survival in those refusing surgery. ( 30933393 )
2019
2
A case of squamous cell carcinoma of the nasal cavity in a patient with granulomatosis with polyangiitis (Wegener granulomatosis). ( 29493730 )
2018
3
Combination Intensity Modulated Proton Therapy and Passive Scatter Boost for Rapidly Progressing Nasal Cavity Squamous Cell Carcinoma. ( 29152442 )
2017
4
Risk of lymph node metastasis and recommendations for elective nodal treatment in squamous cell carcinoma of the nasal cavity and maxillary sinus: a SEER analysis. ( 27685421 )
2016
5
A clinical study of multimodal treatment for orbital organ preservation in locally advanced squamous cell carcinoma of the nasal cavity and paranasal sinus. ( 27207888 )
2016
6
Squamous cell carcinoma of the nasal cavity: A population-based analysis. ( 26297930 )
2016
7
Management for squamous cell carcinoma of the nasal cavity and ethmoid sinus: A single institution experience. ( 25748513 )
2015
8
[Expression and significance of matrix metalloproteinase and tissue inhibitor of metalloproteinase in nasal cavity squamous cell carcinoma]. ( 21624249 )
2011
9
Regional recurrence of squamous cell carcinoma of the nasal cavity: a systematic review and meta-analysis. ( 17709619 )
2007
10
Nasal cavity squamous cell carcinoma presenting as a nasal sidewall nodule: treatment with Mohs surgery, partial rhinectomy, and adjuvant radiotherapy. ( 16681669 )
2006
11
Cerebral radionecrosis with cystic degeneration following radiotherapy for nasal cavity squamous cell carcinoma: a case report. ( 15253473 )
2004
12
Nasal cavity squamous cell carcinoma in Wegener's granulomatosis. ( 11405874 )
2001
13
Cobalt 60 radiotherapy for treatment of squamous cell carcinoma of the nasal cavity and paranasal sinuses in three horses. ( 9530425 )
1998
14
Clinical assessment of squamous cell carcinoma of the nasal cavity proper. ( 8561698 )
1995
15
Radiotherapy for squamous cell carcinoma of the nasal cavity. ( 8372243 )
1993
16
Squamous cell carcinoma of the nasal cavity. ( 706430 )
1978
17
Epithelial papilloma and squamous cell carcinoma of the nasal cavity and paranasal sinuses: a clinicopathological study. ( 1000480 )
1976
18
Squamous cell carcinoma of the nasal cavity. ( 18897184 )
1947

Variations for Nasal Cavity Squamous Cell Carcinoma

Expression for Nasal Cavity Squamous Cell Carcinoma

Search GEO for disease gene expression data for Nasal Cavity Squamous Cell Carcinoma.

Pathways for Nasal Cavity Squamous Cell Carcinoma

GO Terms for Nasal Cavity Squamous Cell Carcinoma

Cellular components related to Nasal Cavity Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 9.13 KRT5 KRT7 KRT8
2 extracellular matrix GO:0031012 8.92 MMP2 MMP9 TIMP1 TIMP2

Biological processes related to Nasal Cavity Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.43 KRT5 KRT7 KRT8
2 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.16 TIMP1 TIMP2
3 negative regulation of metallopeptidase activity GO:1905049 8.96 TIMP1 TIMP2
4 extracellular matrix disassembly GO:0022617 8.92 MMP2 MMP9 TIMP1 TIMP2

Molecular functions related to Nasal Cavity Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metalloendopeptidase inhibitor activity GO:0008191 8.62 TIMP1 TIMP2

Sources for Nasal Cavity Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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