MCID: NSL006
MIFTS: 34

Nasal Cavity Squamous Cell Carcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Nasal Cavity Squamous Cell Carcinoma

MalaCards integrated aliases for Nasal Cavity Squamous Cell Carcinoma:

Name: Nasal Cavity Squamous Cell Carcinoma 12 15 73
Squamous Cell Carcinoma of the Nasal Cavity 12
Squamous Cell Carcinoma of Nasal Cavity 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5515
NCIt 50 C8192
UMLS 73 C0280333

Summaries for Nasal Cavity Squamous Cell Carcinoma

Disease Ontology : 12 A nasal cavity carcinoma that has material basis in squamous cells.

MalaCards based summary : Nasal Cavity Squamous Cell Carcinoma, also known as squamous cell carcinoma of the nasal cavity, is related to squamous cell carcinoma, head and neck and extracranial arteriovenous malformation, and has symptoms including pain and rhinorrhea. An important gene associated with Nasal Cavity Squamous Cell Carcinoma is MMP2 (Matrix Metallopeptidase 2), and among its related pathways/superpathways are Degradation of the extracellular matrix and Interleukin-4 and 13 signaling. The drugs Raspberry and Cola have been mentioned in the context of this disorder. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Nasal Cavity Squamous Cell Carcinoma

Diseases related to Nasal Cavity Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma, head and neck 11.5
2 extracranial arteriovenous malformation 10.9 MMP2 MMP9
3 focal myositis 10.9 MMP2 MMP9
4 spastic entropion 10.9 MMP2 MMP9
5 villous adenocarcinoma 10.9 MMP2 MMP9
6 psammomatous meningioma 10.9 MMP2 MMP9
7 acute transverse myelitis 10.9 MMP2 MMP9
8 senile ectropion 10.9 MMP2 MMP9
9 internal hemorrhoid 10.8 MMP2 MMP9
10 ischemic colitis 10.8 MMP2 MMP9
11 parotitis 10.8 MMP2 MMP9
12 light chain deposition disease 10.8 MMP2 MMP9
13 vulvar intraepithelial neoplasia 10.8 KRT5 MMP2
14 klatskin's tumor 10.8 MMP2 MMP9
15 gingival hypertrophy 10.8 MMP9 TIMP2
16 autoimmune inner ear disease 10.7 MMP9 TIMP1
17 proliferating trichilemmal cyst 10.7 KRT7 KRT8
18 endolymphatic sac tumor 10.7 KRT7 KRT8
19 chronic venous leg ulcers 10.7 MMP9 TIMP1
20 diabetic foot ulcers 10.7 MMP9 TIMP1
21 corneal ulcer 10.7 MMP2 MMP9
22 intratubular embryonal carcinoma 10.7 KRT7 MMP9
23 benign breast adenomyoepithelioma 10.7 KRT5 KRT7
24 hidrocystoma 10.7 KRT7 KRT8
25 malignant spiradenoma 10.7 KRT5 KRT7
26 sensory organ benign neoplasm 10.7 KRT5 KRT7
27 cutaneous adenocystic carcinoma 10.7 KRT7 KRT8
28 bile duct mucoepidermoid carcinoma 10.7 KRT5 KRT7
29 middle ear adenoma 10.7 KRT5 KRT7
30 odontoma 10.6 KRT5 KRT8
31 papillary adenoma 10.6 KRT5 KRT7
32 cryptogenic organizing pneumonia 10.6 MMP9 TIMP1
33 apocrine adenocarcinoma 10.6 KRT5 KRT7
34 brooke-spiegler syndrome 10.6 KRT7 KRT8
35 odontogenic myxoma 10.6 MMP2 MMP9
36 adenomyosis 10.6 MMP2 MMP9 TIMP2
37 transverse myelitis 10.6 MMP2 MMP9
38 pleomorphic carcinoma 10.6 KRT7 KRT8
39 malignant biphasic mesothelioma 10.5 KRT5 KRT7
40 mucinous tubular and spindle renal cell carcinoma 10.5 KRT7 KRT8
41 breast adenomyoepithelioma 10.5 KRT5 KRT7
42 fibrolamellar carcinoma 10.5 KRT7 KRT8
43 breast myoepithelial neoplasm 10.5 KRT5 KRT7
44 hypertrophic scars 10.5 MMP2 TIMP1
45 lung giant cell carcinoma 10.5 MMP2 MMP9 TIMP1
46 keratinizing squamous cell carcinoma 10.5 CDKN2A KRT5
47 optic nerve sheath meningioma 10.5 CDKN2A KRT5
48 aortic disease 10.5 MMP2 MMP9 TIMP1
49 periodontitis 10.4 MMP2 MMP9 TIMP1
50 pleomorphic liposarcoma 10.4 CDKN2A KRT8

Graphical network of the top 20 diseases related to Nasal Cavity Squamous Cell Carcinoma:



Diseases related to Nasal Cavity Squamous Cell Carcinoma

Symptoms & Phenotypes for Nasal Cavity Squamous Cell Carcinoma

UMLS symptoms related to Nasal Cavity Squamous Cell Carcinoma:


pain, rhinorrhea

GenomeRNAi Phenotypes related to Nasal Cavity Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.44 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.44 KRT5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.44 KRT5 KRT8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.44 KRT5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.44 KRT8
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.44 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.44 KRT5 KRT7 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.44 KRT7
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.44 KRT5 KRT7

MGI Mouse Phenotypes related to Nasal Cavity Squamous Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.28 ANKRD11 CDKN2A FRS2 KRT5 KRT8 MMP2

Drugs & Therapeutics for Nasal Cavity Squamous Cell Carcinoma

Drugs for Nasal Cavity Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Raspberry Approved, Nutraceutical Phase 1, Phase 2
2 Cola Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 1b Food Based Modulation of Biomarkers in Human Tissues at High-Risk for Oral Cancer. Completed NCT01469429 Phase 1, Phase 2 chemoprevention;chemoprevention
2 ONYX-015 With Cisplatin and Fluorouracil in Treating Patients With Advanced Head and Neck Cancer Withdrawn NCT00006106 Phase 1 cisplatin;fluorouracil;ONYX-015
3 Questionnaire in Screening Older Patients With Cancer Completed NCT00963911 Not Applicable

Search NIH Clinical Center for Nasal Cavity Squamous Cell Carcinoma

Genetic Tests for Nasal Cavity Squamous Cell Carcinoma

Anatomical Context for Nasal Cavity Squamous Cell Carcinoma

Publications for Nasal Cavity Squamous Cell Carcinoma

Articles related to Nasal Cavity Squamous Cell Carcinoma:

# Title Authors Year
1
Combination Intensity Modulated Proton Therapy and Passive Scatter Boost for Rapidly Progressing Nasal Cavity Squamous Cell Carcinoma. ( 29152442 )
2017
2
[Expression and significance of matrix metalloproteinase and tissue inhibitor of metalloproteinase in nasal cavity squamous cell carcinoma]. ( 21624249 )
2011
3
Nasal cavity squamous cell carcinoma presenting as a nasal sidewall nodule: treatment with Mohs surgery, partial rhinectomy, and adjuvant radiotherapy. ( 16681669 )
2006
4
Cerebral radionecrosis with cystic degeneration following radiotherapy for nasal cavity squamous cell carcinoma: a case report. ( 15253473 )
2004
5
Nasal cavity squamous cell carcinoma in Wegener's granulomatosis. ( 11405874 )
2001

Variations for Nasal Cavity Squamous Cell Carcinoma

Cosmic variations for Nasal Cavity Squamous Cell Carcinoma:

9
(show top 50) (show all 89)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM1610880 TP53 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.97-1G>T p.? 17:7676273-7676273 14
2 COSM10704 TP53 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.844C>T p.R282W 17:7673776-7673776 14
3 COSM44097 TP53 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.530C>T p.P177L 17:7675082-7675082 14
4 COSM43555 TP53 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.736A>G p.M246V 17:7674227-7674227 14
5 COSM10660 TP53 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.818G>A p.R273H 17:7673802-7673802 14
6 COSM43962 TP53 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.805A>G p.S269G 17:7673815-7673815 14
7 COSM10648 TP53 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.524G>A p.R175H 17:7675088-7675088 14
8 COSM43881 TP53 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.757A>T p.T253S 17:7674206-7674206 14
9 COSM10659 TP53 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.817C>T p.R273C 17:7673803-7673803 14
10 COSM44338 TP53 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.845G>A p.R282Q 17:7673775-7673775 14
11 COSM45046 TP53 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.542G>C p.R181P 17:7675070-7675070 14
12 COSM10647 TP53 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.404G>T p.C135F 17:7675208-7675208 14
13 COSM10654 TP53 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.637C>T p.R213* 17:7674894-7674894 14
14 COSM10651 TP53 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.530C>G p.P177R 17:7675082-7675082 14
15 COSM27173 TP53 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.360G>T p.K120N 17:7676009-7676009 14
16 COSM44312 TP53 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.511G>A p.E171K 17:7675101-7675101 14
17 COSM10656 TP53 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.742C>T p.R248W 17:7674221-7674221 14
18 COSM10650 TP53 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.529C>T p.P177S 17:7675083-7675083 14
19 COSM4531793 SUZ12 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.1825G>A p.G609R 17:31996828-31996828 14
20 COSM6973197 SUZ12 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.1639G>C p.E547Q 17:31995607-31995607 14
21 COSM20953 STK11 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.613G>A p.A205T 19:1220596-1220596 14
22 COSM6917769 RAD51 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.595C>T p.H199Y 15:40728775-40728775 14
23 COSM5159 PTEN upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.733C>T p.Q245* 10:87957951-87957951 14
24 COSM5152 PTEN upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.388C>T p.R130* 10:87933147-87933147 14
25 COSM5150 PTEN upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.640C>T p.Q214* 10:87957858-87957858 14
26 COSM775 PIK3CA upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.3140A>G p.H1047R 3:179234297-179234297 14
27 COSM763 PIK3CA upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.1633G>A p.E545K 3:179218303-179218303 14
28 COSM6917771 NTRK3 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.1356G>C p.M452I 15:88126311-88126311 14
29 COSM6973188 NSD1 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.5074C>G p.H1692D 5:177260096-177260096 14
30 COSM581 NRAS upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.181C>G p.Q61E 1:114713909-114713909 14
31 COSM6973198 NOTCH3 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.2641G>A p.G881S 19:15181727-15181727 14
32 COSM6973185 NOTCH2 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.5458G>C p.D1820H 1:119920250-119920250 14
33 COSM120958 NFE2L2 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.235G>C p.E79Q 2:177234082-177234082 14
34 COSM6925124 MYCN upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.1148G>A p.R383H 2:15945850-15945850 14
35 COSM6973195 LATS2 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.2827G>C p.E943Q 13:20975310-20975310 14
36 COSM522 KRAS upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.35G>C p.G12A 12:25245350-25245350 14
37 COSM551 KRAS upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.182A>C p.Q61P 12:25227342-25227342 14
38 COSM518 KRAS upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.34G>C p.G12R 12:25245351-25245351 14
39 COSM693712 KMT2D upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.13900C>T p.R4634* 12:49027256-49027256 14
40 COSM6917763 JAK2 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.28G>C p.E10Q 9:5022015-5022015 14
41 COSM487 HRAS upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.37G>A p.G13S 11:534286-534286 14
42 COSM500 HRAS upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.182A>C p.Q61P 11:533874-533874 14
43 COSM6923245 HRAS upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.64C>A p.Q22K 11:534259-534259 14
44 COSM6973196 GRIN2A upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.2008T>A p.F670I 16:9822424-9822424 14
45 COSM6917762 FGFR3 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.1584G>C p.M528I 4:1805608-1805608 14
46 COSM24842 FGFR3 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.1138G>A p.G380R 4:1804392-1804392 14
47 COSM6917767 FGFR2 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.1433G>A p.R478K 10:121503796-121503796 14
48 COSM6960306 ETV1 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.755C>G p.P252R 7:13931549-13931549 14
49 COSM6960303 EPHA3 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.2945C>T p.P982L 3:89479495-89479495 14
50 COSM6942122 CDK12 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,squamous cell carcinoma c.2045C>T p.P682L 17:39490670-39490670 14

Expression for Nasal Cavity Squamous Cell Carcinoma

Search GEO for disease gene expression data for Nasal Cavity Squamous Cell Carcinoma.

Pathways for Nasal Cavity Squamous Cell Carcinoma

GO Terms for Nasal Cavity Squamous Cell Carcinoma

Cellular components related to Nasal Cavity Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 9.13 KRT5 KRT7 KRT8
2 extracellular matrix GO:0031012 8.92 MMP2 MMP9 TIMP1 TIMP2

Biological processes related to Nasal Cavity Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.43 KRT5 KRT7 KRT8
2 endodermal cell differentiation GO:0035987 9.32 MMP2 MMP9
3 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.16 TIMP1 TIMP2
4 negative regulation of metallopeptidase activity GO:1905049 8.96 TIMP1 TIMP2
5 extracellular matrix disassembly GO:0022617 8.92 MMP2 MMP9 TIMP1 TIMP2

Molecular functions related to Nasal Cavity Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.77 ANKRD11 CDKN2A CXCL11 FRS2 KRT5 KRT7
2 metalloendopeptidase inhibitor activity GO:0008191 8.62 TIMP1 TIMP2

Sources for Nasal Cavity Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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