NPCA2
MCID: NSP009
MIFTS: 22

Nasopharyngeal Carcinoma 2 (NPCA2)

Categories: Cancer diseases, Gastrointestinal diseases, Genetic diseases, Oral diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Nasopharyngeal Carcinoma 2

MalaCards integrated aliases for Nasopharyngeal Carcinoma 2:

Name: Nasopharyngeal Carcinoma 2 56
Nasopharyngeal Carcinoma, Susceptibility to, 2 56 13 71
Npca2 56

Characteristics:

OMIM:

56
Inheritance:
questionably mendelian, but strong genetic factor involved


Classifications:



External Ids:

OMIM 56 161550
MedGen 41 C2750548
SNOMED-CT via HPO 68 108369006 363346000
UMLS 71 C2750548

Summaries for Nasopharyngeal Carcinoma 2

OMIM : 56 Nasopharyngeal carcinoma is a multifactorial malignancy associated with both genetic and environmental factors. The cancer arises from the epithelium of the nasopharynx (summary by Tse et al., 2009). For a general phenotypic description and a discussion of genetic heterogeneity of susceptibility to nasopharyngeal carcinoma, see NPCA1 (607107). (161550)

MalaCards based summary : Nasopharyngeal Carcinoma 2, also known as nasopharyngeal carcinoma, susceptibility to, 2, is related to nasopharyngeal carcinoma. An important gene associated with Nasopharyngeal Carcinoma 2 is NPCA2 (Nasopharyngeal Carcinoma, Susceptibility To, 2). The drugs Cisplatin and Methylcobalamin have been mentioned in the context of this disorder. Affiliated tissues include brain, and related phenotype is neoplasm.

Related Diseases for Nasopharyngeal Carcinoma 2

Diseases in the Nasopharyngeal Carcinoma family:

Nasopharyngeal Carcinoma 2 Nasopharyngeal Carcinoma 3

Diseases related to Nasopharyngeal Carcinoma 2 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 nasopharyngeal carcinoma 11.4

Symptoms & Phenotypes for Nasopharyngeal Carcinoma 2

Human phenotypes related to Nasopharyngeal Carcinoma 2:

31
# Description HPO Frequency HPO Source Accession
1 neoplasm 31 HP:0002664

Symptoms via clinical synopsis from OMIM:

56
Oncology:
nasopharyngeal cancer

Misc:
100-fold higher frequency in southern china than europe
males more frequently affected than females
hla linked gene confers greatly ineased risk

Clinical features from OMIM:

161550

Drugs & Therapeutics for Nasopharyngeal Carcinoma 2

Drugs for Nasopharyngeal Carcinoma 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
2
Methylcobalamin Approved, Investigational Phase 2 13422-55-4
3
Hydroxocobalamin Approved Phase 2 13422-51-0 15589840 11953898
4
Sargramostim Approved, Investigational Phase 2 83869-56-1, 123774-72-1
5
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
6
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
7
Cyanocobalamin Approved, Nutraceutical Phase 2 68-19-9 44176380
8 Molgramostim Investigational Phase 2 99283-10-0
9
Cobalamin Experimental Phase 2 13408-78-1 6857388
10 Micronutrients Phase 2
11 Trace Elements Phase 2
12 Vitamins Phase 2
13 Vitamin B Complex Phase 2
14 Vitamin B 12 Phase 2
15 Hematinics Phase 2
16 Pharmaceutical Solutions Phase 2
17 Folate Phase 2
18 Nutrients Phase 2
19 Vitamin B12 Phase 2
20 Vitamin B9 Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multi-center Phase II Clinical Randomized Study of Chronomodulated Chemotherapy Followed by Concurrent Chemo-radiotherapy With IMRT in the Treatment of Advanced Nasopharyngeal Cancer Unknown status NCT02937519 Phase 2 induction Chrono-chemotherapy;induction Routine-chemotherapy;cisplatin chrono-chemotherapy;cisplatin routine-chemotherapy
2 A Open,Randomized Phase II Trial Comparing Local Use of rhGM-CSF and Compound Vitamin B12 Solution to Compound Vitamin B12 Solution Alone Treating Chemoradiotherapy-induced Oral Mucositis in Patients With Primary Nasopharyngeal Carcinoma Unknown status NCT01806272 Phase 2 rhGM-CSF;Compound Vitamin B12

Search NIH Clinical Center for Nasopharyngeal Carcinoma 2

Genetic Tests for Nasopharyngeal Carcinoma 2

Anatomical Context for Nasopharyngeal Carcinoma 2

MalaCards organs/tissues related to Nasopharyngeal Carcinoma 2:

40
Brain

Publications for Nasopharyngeal Carcinoma 2

Articles related to Nasopharyngeal Carcinoma 2:

(show all 13)
# Title Authors PMID Year
1
Genome-wide association study reveals multiple nasopharyngeal carcinoma-associated loci within the HLA region at chromosome 6p21.3. 56
19664746 2009
2
Association between microsatellites within the human MHC and nasopharyngeal carcinoma. 56
9133461 1997
3
Familial aggregation of nasopharyngeal carcinoma and other malignancies. A clinicopathologic description. 56
1651806 1991
4
Linkage of a nasopharyngeal carcinoma susceptibility locus to the HLA region. 56
2377207 1990
5
HLA and nasopharyngeal carcinoma in Chinese--a further study. 56
6874140 1983
6
Surgical management of parapharyngeal space tumors: The role of cervical and lateral skull base approaches. 61
27929599 2016
7
Radiation recall after capecitabine in a patient with recurrent nasopharyngeal carcinoma: a case report. 61
27604462 2016
8
[Expression of MMP-9 and TIMP-1 in nasopharyngeal carcinoma and its signification at Xi'an and Shenzhen]. 61
20545111 2010
9
Endoscopic endonasal surgery for biopsy of cavernous sinus lesions. 61
19452412 2009
10
Solid tumors subsequent to arsenic trioxide treatment for acute promyelocytic leukemia. 61
16725199 2007
11
The stress-responsive gene GADD45G is a functional tumor suppressor, with its response to environmental stresses frequently disrupted epigenetically in multiple tumors. 61
16166418 2005
12
[Value of CT scan in the early diagnosis of nasopharyngeal tumor]. 61
15318638 2004
13
[Diagnostic evaluation of coronal CT scan in skull and brain diseases]. 61
2591938 1989

Variations for Nasopharyngeal Carcinoma 2

Cosmic variations for Nasopharyngeal Carcinoma 2:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM93183975 upper aerodigestive tract,nasopharynx,carcinoma,nasopharyngeal carcinoma c.742C>T p.R248W 17:7674221-7674221 0

Expression for Nasopharyngeal Carcinoma 2

Search GEO for disease gene expression data for Nasopharyngeal Carcinoma 2.

Pathways for Nasopharyngeal Carcinoma 2

GO Terms for Nasopharyngeal Carcinoma 2

Sources for Nasopharyngeal Carcinoma 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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