MCID: NSP002
MIFTS: 43

Nasopharyngitis

Categories: Oral diseases, Respiratory diseases

Aliases & Classifications for Nasopharyngitis

MalaCards integrated aliases for Nasopharyngitis:

Name: Nasopharyngitis 12 74 54 43 15 71
Chronic Nasopharyngitis 12 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:10460
ICD9CM 34 472.2
MeSH 43 D009304
NCIt 49 C34837
SNOMED-CT 67 47841006 51476001
ICD10 32 J00 J31.1
UMLS 71 C0027441 C0155826

Summaries for Nasopharyngitis

Disease Ontology : 12 A nasopharyngeal disease which involves inflammation of the nasal passages and upper part of the pharynx.

MalaCards based summary : Nasopharyngitis, also known as chronic nasopharyngitis, is related to common cold and pharyngitis. An important gene associated with Nasopharyngitis is DPP4 (Dipeptidyl Peptidase 4), and among its related pathways/superpathways are Peptide hormone metabolism and Glucose / Energy Metabolism. The drugs Mirabegron and Omeprazole have been mentioned in the context of this disorder. Affiliated tissues include kidney, prostate and bone, and related phenotype is homeostasis/metabolism.

Wikipedia : 74 The common cold, also known simply as a cold, is a viral infectious disease of the upper respiratory... more...

Related Diseases for Nasopharyngitis

Diseases related to Nasopharyngitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1155)
# Related Disease Score Top Affiliating Genes
1 common cold 33.5 TNF IL17A CCR6
2 pharyngitis 33.2 TNFRSF1B TNF GPT CRP
3 otitis media 31.6 TNF IL17A GPT CRP
4 covid-19 31.3 GPT DPP4 CRP
5 bronchiolitis 31.1 TNF IL17A CRP
6 neutropenia 31.1 TNF GPT CYP3A4 CRP
7 sleep apnea 31.0 TNF INS GPT CRP
8 severe acute respiratory syndrome 30.8 TNF IFNB1 GPT CRP
9 aspiration pneumonia 30.8 IL17A GPT CRP
10 chlamydia 30.5 TNF IL17A CRP
11 sarcoidosis 1 30.5 TNFRSF1B TNF CRP CCR6
12 exanthem 30.5 TNFRSF1B TNF GPT CYP3A4 CRP CCR6
13 middle ear disease 30.4 TNF CRP CCR6
14 vasculitis 30.4 TNFRSF1B TNF IL17A CRP
15 myelitis 30.4 TNF IL17A IFNB1 CCR6
16 bacterial meningitis 30.4 TNF IL17A CRP
17 allergic hypersensitivity disease 30.4 TNF IL17A CYP3A4 CCR6
18 lymphadenitis 30.4 TNF CRP CCR6
19 proteasome-associated autoinflammatory syndrome 1 30.4 TNF IL17A CRP
20 lymph node disease 30.3 TNF IL17A CRP CCR6
21 apnea, obstructive sleep 30.3 TNF INS GPT GCG CRP
22 hypothyroidism 30.3 TNF INS IFNB1 GPT CYP3A4 CRP
23 streptococcus pneumonia 30.3 TNF IL17A CRP CCR6
24 pneumonia 30.2 TNFRSF1B TNF IL17A IFNB1 GPT CRP
25 cellulitis 30.2 TNF IL17A CRP CCR6
26 mucormycosis 30.2 INS CYP3A4 CRP CCR6
27 immune deficiency disease 30.2 TNF IFNB1 GPT CYP3A4 CCR6
28 acquired immunodeficiency syndrome 30.1 TNFRSF1B TNF CRP CCR6
29 optic nerve disease 30.1 TNF IL17A IFNB1 CRP CCR6
30 bacterial infectious disease 30.1 TNF IL17A IFNB1 CRP CCR6
31 bronchopneumonia 30.1 TNF GPT CRP
32 hypercholesterolemia, familial, 1 30.1 PCSK9 INS GPT CRP
33 nose disease 30.1 TNF IL17A CRP CCR6
34 petrositis 30.1 GCG CRP
35 meningoencephalitis 30.1 TNF CRP CCR6
36 rubella 30.1 TNFRSF1B TNF IFNB1 GPT
37 malignant otitis externa 30.1 INS CRP
38 mycobacterium tuberculosis 1 30.0 TNFRSF1B TNF IL17A IFNB1 CYP3A4 CRP
39 secondary progressive multiple sclerosis 30.0 IL17A IFNB1 CCR6
40 blastomycosis 30.0 TNF IL17A CCR6
41 pneumocystosis 30.0 TNFRSF1B TNF CRP CCR6
42 herpes zoster 30.0 TNFRSF1B TNF CRP CCR6
43 chickenpox 30.0 TNFRSF1B TNF IFNB1 CRP CCR6
44 cryptococcosis 30.0 TNF IL17A CCR6
45 hyperthyroidism 30.0 TNF INS GPT CRP
46 endocarditis 29.9 TNFRSF1B TNF IL17A CRP
47 bilirubin metabolic disorder 29.9 GPT CYP3A4 CRP
48 syphilis 29.9 TNF IL17A GPT CRP CCR6
49 bacterial pneumonia 29.9 TNF IL17A GPT CRP CCR6
50 granulomatosis with polyangiitis 29.9 TNFRSF1B TNF IL17A CRP CCR6

Graphical network of the top 20 diseases related to Nasopharyngitis:



Diseases related to Nasopharyngitis

Symptoms & Phenotypes for Nasopharyngitis

MGI Mouse Phenotypes related to Nasopharyngitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.47 AGPS CCR6 CRP DPP4 DPP9 GIP

Drugs & Therapeutics for Nasopharyngitis

Drugs for Nasopharyngitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mirabegron Approved Phase 4 223673-61-8 9865528
2
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
3 Adrenergic beta-Agonists Phase 4
4 Adrenergic Agents Phase 4
5 Cholinergic Agents Phase 4
6 Solifenacin succinate Phase 4 242478-38-2
7 Adrenergic beta-3 Receptor Agonists Phase 4
8 Adrenergic Agonists Phase 4
9 Muscarinic Antagonists Phase 4
10 Cholinergic Antagonists Phase 4
11 Neurotransmitter Agents Phase 4
12 Antacids Phase 4
13 Proton Pump Inhibitors Phase 4
14 Anti-Ulcer Agents Phase 4
15 Gastrointestinal Agents Phase 4
16
Bortezomib Approved, Investigational Phase 2 179324-69-7 387447 93860
17 Siltuximab Approved, Investigational Phase 1, Phase 2 541502-14-1
18
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
19 Immunoglobulins Phase 2
20 Antibodies Phase 2
21 Pharmaceutical Solutions Phase 2
22 Proteasome Inhibitors Phase 2
23 Anti-Infective Agents Phase 2
24 Antiviral Agents Phase 2
25 Anti-HIV Agents Phase 2
26 Anti-Retroviral Agents Phase 2
27 Antineoplastic Agents, Immunological Phase 2
28 Zanolimumab Phase 2
29 Immunoglobulins, Intravenous Phase 1
30 Antibodies, Monoclonal Phase 1
31
4-Aminopyridine Approved 504-24-5 1727
32
Atorvastatin Approved 134523-00-5 60823
33 Anti-Bacterial Agents
34 Antibiotics, Antitubercular
35 Hypolipidemic Agents
36 Lipid Regulating Agents
37 Hydroxymethylglutaryl-CoA Reductase Inhibitors
38 Anticholesteremic Agents
39 Antimetabolites
40 Acidophilus

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Mirabegron Compared With Solifenacin in Treatment of Overactive Bladder Completed NCT03558919 Phase 4 Mirabegron 25mg;Solifenacin Succinate 5 MG
2 Effectiveness of Vonoprazan vs Omeprazole as Empiric Therapy for Gastroesophageal Reflux Disease (GERD) Patients Without Alarm Features in a Primary Care Setting: A Pragmatic, Randomized, Single Blind Study Recruiting NCT04028466 Phase 4 Vonoprazan;Omeprazole
3 Bortezomib in Late Antibody-mediated Kidney Transplant Rejection (BORTEJECT Study) Completed NCT01873157 Phase 2 Bortezomib;Placebo
4 A Randomized Controlled Trial of Adjunctive Siltuximab in Schizophrenia Recruiting NCT02796859 Phase 1, Phase 2 Siltuximab;normal saline
5 Phase II Study of Aldesleukin (IL-2) Following the Administration of Zanolimumab (Anti-CD4mAb) in Metastatic Melanoma and Metastatic Renal Cancer Terminated NCT01160445 Phase 2 Zanolimumab;Aldesleukin
6 An Open-Label Trial of Tocilizumab in Schizophrenia Completed NCT01696929 Phase 1 Tocilizumab
7 A Randomized Controlled Trial of Adjunctive Tocilizumab in Schizophrenia Recruiting NCT02874573 Phase 1 Tocilizumab;Normal saline
8 Post-market Study of AMAP Receptor Antagonists for Epilepsy Patients in Hong Kong Unknown status NCT03457961 Perampanel
9 A Prospective Study of Molecular Detection of Salvageable Early Recurrent Nasopharyngeal Carcinoma After Radiotherapy Unknown status NCT03379610
10 Use of Behavioral Economics to Improve Treatment of Acute Respiratory Infections (Pilot Study) Completed NCT01454960
11 Use of Behavioral Economics to Improve Treatment of Acute Respiratory Infections (Main Study) Completed NCT01454947
12 Observational Study for Assessment of the Effect of Fampyra on the Manual Function of Persons With Multiple Sclerosis Completed NCT01547234
13 The Effect of Seven-Day Atorvastatin Administration on Emotional Processing, Reward Processing, and Inflammation in Healthy Volunteers Recruiting NCT03966859 Atorvastatin 20mg
14 Effect of the Consumption of a Fermented Milk on Common Infections in Adults Submitted to Multi-stressor Situation Terminated NCT01315418

Search NIH Clinical Center for Nasopharyngitis

Cochrane evidence based reviews: nasopharyngitis

Genetic Tests for Nasopharyngitis

Anatomical Context for Nasopharyngitis

MalaCards organs/tissues related to Nasopharyngitis:

40
Kidney, Prostate, Bone, Myeloid, T Cells, Lymph Node, Tonsil

Publications for Nasopharyngitis

Articles related to Nasopharyngitis:

(show top 50) (show all 980)
# Title Authors PMID Year
1
Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis. 54 61
17622601 2007
2
Breastfeeding initiation or duration and longitudinal patterns of infections up to 2 years and skin rash and respiratory symptoms up to 8 years in the EDEN mother-child cohort. 61
31970921 2020
3
Apremilast for psoriasis treatment. 61
32545946 2020
4
Long-term safety of brodalumab in Japanese patients with plaque psoriasis: An open-label extension study. 61
32275086 2020
5
Adverse events with IL-17 and IL-23 inhibitors for psoriasis and psoriatic arthritis: a systematic review and meta-analysis of phase III studies. 61
31721310 2020
6
Dupilumab Provides Favorable Safety and Sustained Efficacy for up to 3 Years in an Open-Label Study of Adults with Moderate-to-Severe Atopic Dermatitis. 61
32557382 2020
7
Painless thyroiditis in a dupilumab-treated patient. 61
32554823 2020
8
Vibegron 50 mg is the optimal algorithm in the pharmacologic management of overactive bladder: outcomes from a systematic review and meta-analysis. 61
32519241 2020
9
Long-term Single Center Experience in Treating Plaque Psoriasis With Guselkumab. 61
32510235 2020
10
Phase 3, Randomized, Double-Blind, Active-Comparator (Darbepoetin Alfa) Study of Oral Roxadustat in CKD Patients with Anemia on Hemodialysis in Japan. 61
32493693 2020
11
Switching from tenofovir disoproxil fumarate to tenofovir alafenamide in virologically suppressed patients with chronic hepatitis B: a randomised, double-blind, phase 3, multicentre non-inferiority study. 61
32087795 2020
12
Adalimumab for maintenance of remission in Crohn's disease. 61
32413933 2020
13
A randomized, controlled, repeat-dose study of batefenterol/fluticasone furoate compared with placebo in the treatment of COPD. 61
32366249 2020
14
Safety and efficacy of topical, fixed-dose combination calcipotriene (0.005%) and betamethasone (0.064% as dipropionate) gel in adolescent patients with scalp and body psoriasis: a phase II trial. 61
31721327 2020
15
A multicenter, phase 2 study to evaluate the efficacy and safety of osilodrostat, a new 11β-hydroxylase inhibitor, in Japanese patients with endogenous Cushing's syndrome other than Cushing's disease. 61
32378529 2020
16
Adverse events of nucleos(t)ide analogues for chronic hepatitis B: a systematic review. 61
32185517 2020
17
Daridorexant, a new dual orexin receptor antagonist, in elderly subjects with insomnia disorder. 61
32341187 2020
18
Long-term safety and efficacy of nalmefene in Japanese patients with alcohol dependence. 61
32359104 2020
19
Evolocumab vs. Ezetimibe in Statin-Intolerant Hyperlipidemic Japanese Patients: Phase 3 GAUSS-4 Trial. 61
31748467 2020
20
Safety of ixekizumab in adult patients with plaque psoriasis, psoriatic arthritis and axial spondyloarthritis: data from 21 clinical trials. 61
32449924 2020
21
Long-term safety and efficacy of mirogabalin in Asian patients with diabetic peripheral neuropathic pain. 61
31722446 2020
22
[Disease spectrum among guests and staff of an international luxury beach resort in the tropics]. 61
32383074 2020
23
Ten years with biosimilar rhGH in clinical practice in Sweden - experience from the prospective PATRO children and adult studies. 61
32349731 2020
24
104 Long-term Efficacy of Lurasidone in Antipsychotic-naïve vs. Antipsychotic-exposed Adolescents with Schizophrenia: Analysis of a Two-Year Study. 61
32331082 2020
25
Efficacy and Safety of Guanfacine Extended-Release in the Treatment of Attention-Deficit/Hyperactivity Disorder in Adults: Results of a Randomized, Double-Blind, Placebo-Controlled Study. 61
32297719 2020
26
Open-label, long-term extension study to evaluate the safety of clascoterone (CB-03-01) cream, 1% twice daily, in patients with acne vulgaris. 61
32348828 2020
27
Dupilumab for Atopic Dermatitis: The Silver Bullet We Have Been Searching for? 61
32382467 2020
28
A Phase 2a Study of DP2 Antagonist GB001 for Asthma. 61
31778823 2020
29
Integrated analysis of transcriptome profiling predicts potential lncRNA and circRNA targets in human nasopharyngeal carcinoma. 61
32218863 2020
30
Safety of calcipotriene and betamethasone dipropionate foam for the treatment of psoriasis. 61
32243212 2020
31
Post-hoc analysis investigating the safety and efficacy of brexpiprazole in Japanese patients with schizophrenia who were switched from other antipsychotics in a long-term study (Secondary Publication). 61
32297486 2020
32
Safety of Romosozumab in Osteoporotic Men and Postmenopausal Women: A Meta-Analysis and Systematic Review. 61
32195618 2020
33
Intermittent Oral Dosing of Roxadustat in Peritoneal Dialysis Chronic Kidney Disease Patients with Anemia: A Randomized, Phase 3, Multicenter, Open-Label Study. 61
31222951 2020
34
172 A Phase 3, Multicenter Study to Assess the Long-Term Safety, Tolerability, and Efficacy of Olanzapine/Samidorphan in Patients with Schizophrenia. 61
32331006 2020
35
Efficacy and safety of adjunctive perampanel in adolescent patients with epilepsy: Post hoc analysis of six randomized studies. 61
31954998 2020
36
Safety and tolerability of adjunctive brivaracetam in children with focal seizures: Interim analysis of pooled data from two open-label trials. 61
31810577 2020
37
Sarilumab monotherapy or in combination with non-methotrexate disease-modifying antirheumatic drugs in active rheumatoid arthritis: A Japan phase 3 trial (HARUKA). 61
31268376 2020
38
Safety and effectiveness of lurasidone for the treatment of schizophrenia in Asian patients: Results of a 26-week open-label extension study. 61
31837113 2020
39
Tiotropium in children and adolescents with asthma. 61
31805357 2020
40
Efficacy and safety of eptinezumab in patients with chronic migraine: PROMISE-2. 61
32209650 2020
41
A Randomized Trial to Evaluate OnabotulinumtoxinA for Prevention of Headaches in Adolescents With Chronic Migraine. 61
32037549 2020
42
Safety and effectiveness of peficitinib (ASP015K) in patients with rheumatoid arthritis: interim data (22.7 months mean peficitinib treatment) from a long-term, open-label extension study in Japan, Korea, and Taiwan. 61
32164762 2020
43
Measures of functional outcomes, work productivity, and quality of life from a randomized, phase 3 study of solriamfetol in participants with narcolepsy. 61
31926465 2020
44
Long-term Efficacy and Tolerability of RPC4046 in an Open-Label Extension Trial of Patients With Eosinophilic Esophagitis. 61
32205221 2020
45
Downregulated long non-coding RNA FOXD3-AS1 promotes endoplasmic reticulum stress-induced apoptosis by inhibiting RCN1 via let-7e-5p in nasopharyngeal carcinoma. 61
32073875 2020
46
Long-term study of the safety and maintenance of efficacy of solriamfetol (JZP-110) in the treatment of excessive sleepiness in participants with narcolepsy or obstructive sleep apnea. 61
31691827 2020
47
Long-term safety and efficacy of delgocitinib ointment, a topical Janus kinase inhibitor, in adult patients with atopic dermatitis. 61
31820485 2020
48
Long-Term Evolocumab in Patients With Familial Hypercholesterolemia. 61
32057369 2020
49
Dupilumab shows long-term safety and efficacy in patients with moderate to severe atopic dermatitis enrolled in a phase 3 open-label extension study. 61
31374300 2020
50
Biologics for chronic rhinosinusitis. 61
32102112 2020

Variations for Nasopharyngitis

Expression for Nasopharyngitis

Search GEO for disease gene expression data for Nasopharyngitis.

Pathways for Nasopharyngitis

GO Terms for Nasopharyngitis

Cellular components related to Nasopharyngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 TNF PCSK9 INS IL17A IFNB1 GPT
2 extracellular region GO:0005576 9.36 TNFRSF1B TNF PCSK9 INS IL17A IFNB1
3 endoplasmic reticulum lumen GO:0005788 9.35 PCSK9 INS GIP GCG AMELX

Biological processes related to Nasopharyngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.77 TNFRSF1B TNF IL17A DPP8 CCR6
2 negative regulation of blood vessel diameter GO:0097756 9.32 INS CRP
3 negative regulation of lipid storage GO:0010888 9.26 TNF CRP
4 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.16 TNF IL17A
5 humoral immune response GO:0006959 9.13 TNF IFNB1 CCR6
6 regulation of insulin secretion GO:0050796 8.92 TNF GIP GCG DPP4

Molecular functions related to Nasopharyngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.76 TNF SEPTIN3 INS GCG DPP9 DPP4
2 serine-type peptidase activity GO:0008236 9.56 PCSK9 DPP9 DPP8 DPP4
3 glucose:sodium symporter activity GO:0005412 9.32 SLC5A4 SLC5A2
4 aminopeptidase activity GO:0004177 9.13 DPP9 DPP8 DPP4
5 glucagon receptor binding GO:0031769 8.62 GIP GCG

Sources for Nasopharyngitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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