MCID: NRF028
MIFTS: 27

Near-Fatal Asthma

Categories: Respiratory diseases

Aliases & Classifications for Near-Fatal Asthma

MalaCards integrated aliases for Near-Fatal Asthma:

Name: Near-Fatal Asthma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0080823

Summaries for Near-Fatal Asthma

Disease Ontology : 12 An acute asthma that is characterized by a respiratory arrest or arterial carbon dioxide tension greater than 50 mmHg, with or without altered consciousness, requiring mechanical ventilation.

MalaCards based summary : Near-Fatal Asthma is related to status asthmaticus and asthma. An important gene associated with Near-Fatal Asthma is CCL2 (C-C Motif Chemokine Ligand 2), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Human cytomegalovirus infection. Affiliated tissues include heart, smooth muscle and t cells.

Related Diseases for Near-Fatal Asthma

Diseases related to Near-Fatal Asthma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 195)
# Related Disease Score Top Affiliating Genes
1 status asthmaticus 30.2 CCL5 ADRB2
2 asthma 30.1 TNF CCL5 CCL2 ADRB2
3 respiratory failure 29.5 TNF CCL5 CCL2 ADRB2
4 pulmonary disease, chronic obstructive 28.9 TNF CCL5 CCL2 ADRB2
5 acute asthma 10.5
6 ige responsiveness, atopic 10.2
7 asthma-related traits 2 10.2
8 alexithymia 10.2
9 cardiac arrest 10.1
10 pneumothorax 10.1
11 rhinitis 10.1
12 conjunctivitis 10.1 TNF CCL2
13 palladium allergic contact dermatitis 10.1 TNF CCL2
14 allergic contact dermatitis 10.1 TNF CCL2
15 contact dermatitis 10.1 TNF CCL2
16 congenital cytomegalovirus 10.1 TNF CCL2
17 anthracosis 10.1 TNF CCL2
18 tuberculous meningitis 10.1 TNF CCL2
19 chlamydia pneumonia 10.1 TNF CCL2
20 chlamydia 10.1 TNF CCL2
21 blood group, globoside system 10.1 TNF CCL2
22 acute proliferative glomerulonephritis 10.1 TNF CCL2
23 retinal vasculitis 10.1 TNF CCL2
24 scleritis 10.1 TNF CCL2
25 vitreous disease 10.1 TNF CCL2
26 pleural tuberculosis 10.1 TNF CCL2
27 drug-induced lupus erythematosus 10.1 TNF CCL2
28 acute kidney tubular necrosis 10.1 TNF CCL2
29 macular retinal edema 10.1 TNF CCL2
30 hepatopulmonary syndrome 10.1 TNF CCL2
31 leukostasis 10.1 TNF CCL2
32 ureteral disease 10.1 TNF CCL2
33 leptospirosis 10.1 TNF CCL2
34 pleurisy 10.1 TNF CCL2
35 coronavirus infectious disease 10.1 TNF CCL2
36 dengue shock syndrome 10.1 TNF CCL2
37 vein disease 10.1 TNF CCL2
38 appendicitis 10.1 TNF CCL2
39 leukemia, acute monocytic 10.1 TNF CCL2
40 retinal vein occlusion 10.1 TNF CCL2
41 acute cystitis 10.1 TNF CCL2
42 cystitis 10.1 TNF CCL2
43 autoimmune uveitis 10.1 TNF CCL2
44 uveitis 10.1 TNF CCL2
45 nephrosclerosis 10.1 TNF CCL2
46 ileus 10.1 TNF CCL2
47 silicosis 10.1 TNF CCL2
48 preterm premature rupture of the membranes 10.0 TNF CCL2
49 pulmonary alveolar proteinosis 10.0 TNF CCL2
50 scorpion envenomation 10.0 TNF CCL5

Graphical network of the top 20 diseases related to Near-Fatal Asthma:



Diseases related to Near-Fatal Asthma

Symptoms & Phenotypes for Near-Fatal Asthma

Drugs & Therapeutics for Near-Fatal Asthma

Search Clinical Trials , NIH Clinical Center for Near-Fatal Asthma

Genetic Tests for Near-Fatal Asthma

Anatomical Context for Near-Fatal Asthma

MalaCards organs/tissues related to Near-Fatal Asthma:

40
Heart, Smooth Muscle, T Cells

Publications for Near-Fatal Asthma

Articles related to Near-Fatal Asthma:

(show top 50) (show all 218)
# Title Authors PMID Year
1
Intravenous and intramuscular therapy in near fatal asthma. A response to Al-Shamrani. 61
33319022 2020
2
Compassionate Use of a Single Dose of Benralizumab in a Near-Fatal Asthma Exacerbation. 61
32938574 2020
3
Emergency room endotracheal intubation in children with bronchiolitis: A cohort study using a multicenter database. 61
32617417 2020
4
Extracorporeal membrane oxygenation for near fatal asthma with sudden cardiac arrest. 61
32543251 2020
5
Extracorporeal and advanced therapies for progressive refractory near-fatal acute severe asthma in children. 61
32227683 2020
6
The Use of Benralizumab in the Treatment of Near-Fatal Asthma: A New Approach. 61
32023077 2020
7
A winter to remember! Extracorporeal membrane oxygenation for life-threatening asthma in children: A case series and review of literature. 61
31860773 2020
8
Extracorporeal carbon dioxide removal in heart-beating donor with acute severe asthma: A case report. 61
32042585 2020
9
Inflammatory and microbiological associations with near-fatal asthma requiring extracorporeal membrane oxygenation. 61
32010717 2020
10
Potentially (near) fatal asthma. 61
31690380 2019
11
Symptoms and perception of airway obstruction in asthmatic patients: Clinical implications for use of reliever medications. 61
31330221 2019
12
Association of depressive symptoms with health status and markers of uncontrolled severe asthma. 61
31262378 2019
13
Fatal and near-fatal thunderstorm asthma epidemic in a desert country. 61
31007768 2019
14
Inflammatory and Comorbid Features of Children Admitted to a PICU for Status Asthmaticus. 61
30106766 2018
15
Overreliance link between asthmatic subjects and short-acting β2 agonists. 61
29653189 2018
16
Identification of patterns of factors preceding severe or life-threatening asthma exacerbations in a nationwide study. 61
29197099 2018
17
Extracorporeal membrane oxygenation (ECMO) for near-fatal asthma refractory to conventional ventilation. 61
29559484 2018
18
Extracorporeal membrane oxygenation for life-threatening asthma refractory to mechanical ventilation: analysis of the Extracorporeal Life Support Organization registry. 61
29212551 2017
19
Rescue therapeutic strategy combining ultra-protective mechanical ventilation with extracorporeal CO2 removal membrane in near-fatal asthma with severe pulmonary barotraumas: A case report. 61
29019893 2017
20
Characterisation of asthma subgroups associated with circulating YKL-40 levels. 61
29025889 2017
21
Long-term future risk of severe exacerbations: Distinct 5-year trajectories of problematic asthma. 61
28295424 2017
22
Near-fatal asthma: a heterogeneous clinical entity. 61
27870665 2017
23
Interventional lung assist and extracorporeal membrane oxygenation in a patient with near-fatal asthma. 61
27553829 2017
24
Acute asthma, prognosis, and treatment. 61
27554811 2017
25
"Awake" ECCO2R superseded intubation in a near-fatal asthma attack. 61
28808576 2017
26
Near-fatal asthma responsive to mepolizumab after failure of omalizumab and bronchial thermoplasty. 61
29184413 2017
27
Sensitization to Aspergillus species is associated with frequent exacerbations in severe asthma. 61
28461762 2017
28
Near Fatal Asthma in an Inner City Population. 61
25285796 2016
29
To: Contemporary treatment of children with critical and near-fatal asthma. 61
27737422 2016
30
Reply to: Contemporary treatment of children with critical and near-fatal asthma. 61
27737429 2016
31
Near fatal asthma: treatment and prevention. 61
27425166 2016
32
Short-term starvation with a near-fatal asthma attack induced ketoacidosis in a nondiabetic pregnant woman: A case report. 61
27368034 2016
33
Contemporary treatment of children with critical and near-fatal asthma. 61
27305039 2016
34
[Severe asthma]. 61
26826988 2016
35
Asthma-related deaths. 61
27752310 2016
36
Fatal asthma; is it still an epidemic? 61
28031774 2016
37
Noninvasive ventilation in status asthmaticus in children: levels of evidence. 61
26761478 2015
38
Identification and characterization of near-fatal asthma phenotypes by cluster analysis. 61
26011771 2015
39
Characteristics and prognosis of near-fatal asthma exacerbations. 61
26083648 2015
40
Safety of β2-Agonists in Asthma: Linking Mechanisms, Meta-Analyses and Regulatory Practice. 61
25712726 2015
41
A case of near fatal asthma: The role of ECMO as rescue therapy. 61
25829967 2015
42
Critical asthma syndrome in the ICU. 61
25759905 2015
43
Management of critical asthma syndrome during pregnancy. 61
24258096 2015
44
Definition of critical asthma syndromes. 61
24213844 2015
45
Near-fatal asthma in the elderly. 61
25470264 2015
46
Loss of asthma control after cessation of omalizumab treatment: real life data. 61
24683390 2014
47
Risk factors, management and outcomes of patients admitted with near fatal asthma to a tertiary care hospital in Riyadh. 61
24551016 2014
48
Critical Asthma Syndrome in the ICU. 61
24234835 2013
49
Aspirin-intolerant asthma: a comprehensive review of biomarkers and pathophysiology. 61
23184151 2013
50
Nebulised DNase post-therapeutic bronchoalveolar lavage in near fatal asthma exacerbation in an adult patient refractory to conventional treatment. 61
23814090 2013

Variations for Near-Fatal Asthma

Expression for Near-Fatal Asthma

Search GEO for disease gene expression data for Near-Fatal Asthma.

Pathways for Near-Fatal Asthma

Pathways related to Near-Fatal Asthma according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.64 TNF CCL5 CCL2
2
Show member pathways
12.53 TNF CCL5 CCL2
3
Show member pathways
12.42 TNF CCL5 CCL2
4 12.4 TNF CCL5 CCL2
5 12.17 TNF CCL5 CCL2
6
Show member pathways
11.91 TNF CCL5 CCL2
7
Show member pathways
11.88 TNF CCL5 CCL2
8 11.76 TNF CCL5 CCL2
9 11.67 TNF CCL2
10 11.64 TNF CCL2
11 11.57 TNF CCL2
12 11.48 TNF CCL5 CCL2
13 11.3 TNF CCL5 CCL2
14 11.21 TNF CCL2
15 11.18 TNF CCL2
16 10.93 TNF CCL5 CCL2
17 10.84 TNF CCL5
18 10.64 TNF CCL2
19 10.63 TNF CCL5 CCL2
20 10.49 TNF CCL5 CCL2

GO Terms for Near-Fatal Asthma

Biological processes related to Near-Fatal Asthma according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.73 TNF CCL5 CCL2
2 inflammatory response GO:0006954 9.69 TNF CCL5 CCL2
3 response to virus GO:0009615 9.63 TNF CCL5
4 cellular response to interferon-gamma GO:0071346 9.63 CCL5 CCL2
5 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.62 TNF CCL5
6 cell chemotaxis GO:0060326 9.62 CCL5 CCL2
7 cellular response to interleukin-1 GO:0071347 9.61 CCL5 CCL2
8 neutrophil chemotaxis GO:0030593 9.61 CCL5 CCL2
9 cytokine-mediated signaling pathway GO:0019221 9.61 TNF CCL5 CCL2
10 regulation of insulin secretion GO:0050796 9.6 TNF CCL5
11 chemokine-mediated signaling pathway GO:0070098 9.59 CCL5 CCL2
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.58 TNF CCL5
13 positive regulation of smooth muscle cell proliferation GO:0048661 9.58 TNF CCL5
14 MAPK cascade GO:0000165 9.58 TNF CCL5 CCL2
15 humoral immune response GO:0006959 9.57 TNF CCL2
16 positive regulation of cell adhesion GO:0045785 9.55 TNF CCL5
17 monocyte chemotaxis GO:0002548 9.54 CCL5 CCL2
18 negative regulation of viral genome replication GO:0045071 9.52 TNF CCL5
19 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.5 TNF CCL5 CCL2
20 lymphocyte chemotaxis GO:0048247 9.49 CCL5 CCL2
21 positive regulation of JAK-STAT cascade GO:0046427 9.48 TNF CCL5
22 cellular response to fibroblast growth factor stimulus GO:0044344 9.46 CCL5 CCL2
23 eosinophil chemotaxis GO:0048245 9.37 CCL5 CCL2
24 cellular response to organic cyclic compound GO:0071407 9.33 TNF CCL5 CCL2
25 macrophage chemotaxis GO:0048246 9.26 CCL5 CCL2
26 protein kinase B signaling GO:0043491 9.13 TNF CCL5 CCL2
27 lipopolysaccharide-mediated signaling pathway GO:0031663 8.8 TNF CCL5 CCL2

Molecular functions related to Near-Fatal Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.16 CCL5 CCL2
2 CCR chemokine receptor binding GO:0048020 8.96 CCL5 CCL2
3 cytokine activity GO:0005125 8.8 TNF CCL5 CCL2

Sources for Near-Fatal Asthma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....