MCID: NCT001
MIFTS: 33

Necatoriasis

Categories: Infectious diseases

Aliases & Classifications for Necatoriasis

MalaCards integrated aliases for Necatoriasis:

Name: Necatoriasis 12 56 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:2790
MeSH 45 D009332
NCIt 51 C34838
SNOMED-CT 69 36667009
ICD10 34 B76.1
UMLS 74 C0027528

Summaries for Necatoriasis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of the small intestine of humans, dogs and cats by the nematode Necator americanus causing abdominal pain, diarrhea, cramps, weight loss and anemia. Cutaneous larvae migrans in humans is characterized by skin ruptures and severe itching.

MalaCards based summary : Necatoriasis is related to atopic keratoconjunctivitis and paragonimiasis. An important gene associated with Necatoriasis is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include skin and small intestine.

Wikipedia : 77 Necatoriasis is the condition of infection by Necator hookworms, such as Necator americanus. This... more...

Related Diseases for Necatoriasis

Diseases related to Necatoriasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
# Related Disease Score Top Affiliating Genes
1 atopic keratoconjunctivitis 10.3 CCL22 IL5
2 paragonimiasis 10.3 CCL17 IL5
3 conjunctivitis 10.3 CXCL8 IL5
4 intestinal volvulus 10.3 CALR IL5
5 bagassosis 10.3 CXCL8 IL5
6 allergic bronchopulmonary aspergillosis 10.3 CCL17 IL5
7 pulmonary eosinophilia 10.3 CCL17 IL5
8 cephalosporin allergy 10.2 IL10 IL5
9 status asthmaticus 10.2 CXCL8 IL5
10 sinusitis 10.2 CXCL8 IL5
11 respiratory syncytial virus infectious disease 10.2 CCL3 IL5
12 nickel allergic contact dermatitis 10.2 IL10 IL5
13 onchocerciasis 10.2 CALR IL5
14 cow milk allergy 10.2 IL10 IL5
15 milk allergy 10.2 IL10 IL5
16 gaucher disease, type ii 10.2 IL10 IL5
17 wells syndrome 10.2 CXCL8 IL5
18 eosinophilic meningitis 10.2 IL10 IL5
19 multicentric castleman disease 10.2 IL10 IL5
20 filarial elephantiasis 10.2 IL10 IL5
21 allergic conjunctivitis 10.2 CXCL8 IL5
22 common cold 10.2 CXCL8 IL5
23 paranasal sinus disease 10.2 IL10 IL5
24 taeniasis 10.2 CALR IL10
25 tungiasis 10.2 CXCL8 IL10
26 acute transverse myelitis 10.2 CXCL8 IL10
27 transverse myelitis 10.2 CXCL8 IL10
28 pouchitis 10.2 CXCL8 IL10
29 nasal cavity disease 10.2 IL10 IL5
30 dermatitis 10.2 CCL17 CCL22 IL5
31 vulvovaginitis 10.2 CXCL8 IL10
32 scabies 10.2 CXCL8 IL10
33 neurosyphilis 10.2 CXCL8 IL10
34 paracoccidioidomycosis 10.2 IL10 IL5
35 stevens-johnson syndrome/toxic epidermal necrolysis 10.1 CCL17 CCL22 IL5
36 funisitis 10.1 CXCL8 IL10
37 eosinophilic pneumonia 10.1 CCL17 CCL22 IL5
38 clonorchiasis 10.1 CXCL8 IL10
39 retinitis pigmentosa 44 10.1 CXCL8 IL10
40 respiratory allergy 10.1 IL10 IL5
41 trichuriasis 10.1
42 ankylostomiasis 10.1
43 mycosis fungoides 10.1 CCL17 CCL22 IL5
44 mycetoma 10.1 CXCL8 IL10
45 tuberculous meningitis 10.1 CCL3 CXCL8
46 aseptic meningitis 10.1 CXCL8 IL10
47 primary peritoneal carcinoma 10.1 CXCL8 IL10
48 acute pyelonephritis 10.1 CXCL8 IL10
49 pyelonephritis 10.1 CXCL8 IL10
50 bacterial sepsis 10.1 CXCL8 IL10

Graphical network of the top 20 diseases related to Necatoriasis:



Diseases related to Necatoriasis

Symptoms & Phenotypes for Necatoriasis

Drugs & Therapeutics for Necatoriasis

Search Clinical Trials , NIH Clinical Center for Necatoriasis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: necatoriasis

Genetic Tests for Necatoriasis

Anatomical Context for Necatoriasis

MalaCards organs/tissues related to Necatoriasis:

42
Skin, Small Intestine

Publications for Necatoriasis

Articles related to Necatoriasis:

# Title Authors Year
1
The assessment of hookworm calreticulin as a potential vaccine for necatoriasis. ( 15910422 )
2005
2
Immune responses in human necatoriasis: association between interleukin-5 responses and resistance to reinfection. ( 15243914 )
2004
3
Epidemiology of human geohelminth infections (ascariasis, trichuriasis and necatoriasis) in Lushui and Puer Counties, Yunnan Province, China. ( 11288999 )
2000
4
Necatoriasis: treatment and developmental therapeutics. ( 11060728 )
2000
5
Parasitic infections. Treatment and developmental therapeutics. 1. Necatoriasis. ( 10438896 )
1999
6
Immunoepidemiology of human necatoriasis: correlations between antibody responses and parasite burdens. ( 7494644 )
1995
7
Evaluation of albendazole, pyrantel, bephenium, pyrantel-praziquantel and pyrantel-bephenium for single-dose mass treatment of necatoriasis. ( 2619378 )
1989
8
Course of egg output over a 15 year period in a case of experimentally induced necatoriasis americanus, in the absence of hyperinfection. ( 13238732 )
1955

Variations for Necatoriasis

Expression for Necatoriasis

Search GEO for disease gene expression data for Necatoriasis.

Pathways for Necatoriasis

Pathways related to Necatoriasis according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 CALR CCL22 CCL3 CCL4 CXCL8 IL10
2
Show member pathways
13.61 CCL17 CCL22 CCL3 CCL4 CXCL8 IL10
3
Show member pathways
13.42 CCL17 CCL22 CCL3 CCL4 CXCL8 IL10
4
Show member pathways
13.29 CCL17 CCL22 CCL3 CCL4 CXCL8 IL10
5
Show member pathways
13.19 CCL17 CCL22 CCL3 CCL4 CXCL8 IL10
6
Show member pathways
13.17 CCL17 CCL22 CCL3 CCL4 CXCL8
7
Show member pathways
13.13 CCL22 CCL3 CCL4 CXCL8 IL10 IL5
8
Show member pathways
13.09 CCL17 CCL22 CCL3 CCL4 CXCL8 IL10
9
Show member pathways
12.99 CALR CCL3 CCL4 CXCL8 IL10
10
Show member pathways
12.74 CALR CCL3 CCL4 CXCL8
11
Show member pathways
12.69 CALR CCL17 CCL22 CCL3 CCL4 CXCL8
12
Show member pathways
12.66 CALR CXCL8 IL10 IL5
13
Show member pathways
12.14 CCL17 CXCL8 IL5
14
Show member pathways
12.03 CCL17 CCL22 CCL3 CCL4 CXCL8
15
Show member pathways
12.02 CCL17 CCL22 IL10
16
Show member pathways
11.83 CCL17 CCL22 CCL3 CCL4 CXCL8
17 11.82 CCL22 CXCL8 IL10
18
Show member pathways
11.71 CCL17 CCL22 CCL3 CCL4 CXCL8 IL10
19 11.69 CCL3 CCL4 CXCL8
20 11.66 CCL3 IL10 IL5
21 11.53 CCL17 IL10 IL5
22 11.53 CCL3 CCL4 CXCL8 IL5
23 11.51 CCL17 CCL22 CCL3 CCL4 IL10
24 11.37 CCL17 CCL22 IL10 IL5
25 11.34 CXCL8 IL10
26 11.09 IL10 IL5
27 11.04 CCL22 CCL3 CCL4 CXCL8 IL10
28 11.03 IL10 IL5
29 10.77 CCL17 CCL22 CCL3 CCL4 CXCL8 IL10
30 10.4 CCL17 CCL22 CCL3 CCL4 CXCL8 IL10

GO Terms for Necatoriasis

Cellular components related to Necatoriasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CALR CCL17 CCL22 CCL3 CCL4 CXCL8
2 extracellular space GO:0005615 9.28 CALR CCL17 CCL22 CCL3 CCL4 CXCL8
3 intracellular GO:0005622 9.16 CALR CCL3

Biological processes related to Necatoriasis according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 chemotaxis GO:0006935 9.89 CCL17 CCL22 CCL3 CCL4 CXCL8
2 cytokine-mediated signaling pathway GO:0019221 9.88 CCL22 CCL3 CCL4 CXCL8 IL10 IL5
3 positive regulation of GTPase activity GO:0043547 9.87 CCL17 CCL22 CCL3 CCL4
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.85 CCL17 CCL22 CCL3 CCL4
5 cell-cell signaling GO:0007267 9.84 CCL17 CCL22 CCL3 CCL4
6 cellular response to tumor necrosis factor GO:0071356 9.83 CCL17 CCL22 CCL3 CCL4 CXCL8
7 cellular response to interferon-gamma GO:0071346 9.81 CCL17 CCL22 CCL3 CCL4
8 immune response GO:0006955 9.8 CCL17 CCL22 CCL3 CCL4 CXCL8 IL10
9 MAPK cascade GO:0000165 9.79 CCL3 EPGN IL5
10 monocyte chemotaxis GO:0002548 9.78 CCL17 CCL22 CCL3 CCL4
11 neutrophil chemotaxis GO:0030593 9.77 CCL17 CCL22 CCL3 CCL4 CXCL8
12 lymphocyte chemotaxis GO:0048247 9.76 CCL17 CCL22 CCL3 CCL4
13 cellular response to interleukin-1 GO:0071347 9.72 CCL17 CCL22 CCL3 CCL4 CXCL8
14 eosinophil chemotaxis GO:0048245 9.7 CCL22 CCL3 CCL4
15 regulation of sensory perception of pain GO:0051930 9.62 CCL3 IL10
16 positive regulation of calcium ion transport GO:0051928 9.61 CCL3 CCL4
17 leukocyte chemotaxis GO:0030595 9.61 CXCL8 IL10
18 positive regulation of calcium-mediated signaling GO:0050850 9.59 CCL3 CCL4
19 negative regulation by host of viral transcription GO:0043922 9.58 CCL3 CCL4
20 response to molecule of bacterial origin GO:0002237 9.58 CXCL8 IL10
21 positive regulation of natural killer cell chemotaxis GO:2000503 9.56 CCL3 CCL4
22 chemokine-mediated signaling pathway GO:0070098 9.55 CCL17 CCL22 CCL3 CCL4 CXCL8
23 regulation of signaling receptor activity GO:0010469 9.5 CCL17 CCL22 CCL3 CCL4 CXCL8 IL10
24 inflammatory response GO:0006954 9.17 CCL17 CCL22 CCL3 CCL4 CXCL8 IL10
25 G protein-coupled receptor signaling pathway GO:0007186 10 CCL17 CCL22 CCL3 CCL4 CXCL8

Molecular functions related to Necatoriasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.54 EPGN IL10 IL5
2 CCR chemokine receptor binding GO:0048020 9.46 CCL17 CCL22 CCL3 CCL4
3 chemokine activity GO:0008009 9.35 CCL17 CCL22 CCL3 CCL4 CXCL8
4 CCR5 chemokine receptor binding GO:0031730 9.32 CCL3 CCL4
5 CCR1 chemokine receptor binding GO:0031726 9.26 CCL3 CCL4
6 cytokine activity GO:0005125 9.17 CCL17 CCL22 CCL3 CCL4 CXCL8 IL10

Sources for Necatoriasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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