MCID: NCT001
MIFTS: 34

Necatoriasis

Categories: Infectious diseases

Aliases & Classifications for Necatoriasis

MalaCards integrated aliases for Necatoriasis:

Name: Necatoriasis 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2790
ICD10 33 B76.1
MeSH 44 D009332
NCIt 50 C34838
SNOMED-CT 68 36667009
UMLS 73 C0027528

Summaries for Necatoriasis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of the small intestine of humans, dogs and cats by the nematode Necator americanus causing abdominal pain, diarrhea, cramps, weight loss and anemia. Cutaneous larvae migrans in humans is characterized by skin ruptures and severe itching.

MalaCards based summary : Necatoriasis is related to trichuriasis and atopic keratoconjunctivitis. An important gene associated with Necatoriasis is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include skin, small intestine and lung.

Wikipedia : 76 Necatoriasis is the condition of infection by Necator hookworms, such as Necator americanus. This... more...

Related Diseases for Necatoriasis

Diseases related to Necatoriasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 trichuriasis 30.4 CXCL8 IL10
2 atopic keratoconjunctivitis 10.2 CCL22 IL5
3 paragonimiasis 10.2 CCL17 IL5
4 bagassosis 10.2 CXCL8 IL5
5 intestinal volvulus 10.2 CALR IL5
6 cephalosporin allergy 10.2 IL10 IL5
7 cardiac sarcoidosis 10.2 CXCL8 IL5
8 ascaris lumbricoides infection 10.2 CXCL8 IL5
9 nickel allergic contact dermatitis 10.2 IL10 IL5
10 cow milk allergy 10.2 IL10 IL5
11 milk allergy 10.2 IL10 IL5
12 allergic bronchopulmonary aspergillosis 10.2 CCL17 IL5
13 status asthmaticus 10.2 CXCL8 IL5
14 gaucher disease, type ii 10.2 IL10 IL5
15 sinusitis 10.2 CXCL8 IL5
16 radiculopathy 10.2 CXCL8 IL5
17 eosinophilic meningitis 10.2 IL10 IL5
18 multicentric castleman disease 10.2 IL10 IL5
19 pulmonary eosinophilia 10.2 CCL17 IL5
20 castleman disease 10.2 IL10 IL5
21 filarial elephantiasis 10.2 IL10 IL5
22 respiratory syncytial virus infectious disease 10.2 CCL3 IL5
23 peanut allergy 10.1 CCL22 IL10
24 tungiasis 10.1 CXCL8 IL10
25 acute transverse myelitis 10.1 CXCL8 IL10
26 transverse myelitis 10.1 CXCL8 IL10
27 wells syndrome 10.1 CXCL8 IL5
28 pouchitis 10.1 CXCL8 IL10
29 onchocerciasis 10.1 CALR IL5
30 vulvovaginitis 10.1 CXCL8 IL10
31 scabies 10.1 CXCL8 IL10
32 neurosyphilis 10.1 CXCL8 IL10
33 taeniasis 10.1 CALR IL10
34 funisitis 10.1 CXCL8 IL10
35 clonorchiasis 10.1 CXCL8 IL10
36 dermatitis 10.1 CCL17 CCL22 IL5
37 retinitis pigmentosa 44 10.1 CXCL8 IL10
38 allergic conjunctivitis 10.1 CXCL8 IL5
39 stevens-johnson syndrome/toxic epidermal necrolysis 10.1 CCL17 CCL22 IL5
40 eosinophilic pneumonia 10.1 CCL17 CCL22 IL5
41 paranasal sinus disease 10.1 IL10 IL5
42 mycosis fungoides 10.1 CCL17 CCL22 IL5
43 mycetoma 10.1 CXCL8 IL10
44 ankylostomiasis 10.1
45 aseptic meningitis 10.1 CXCL8 IL10
46 primary peritoneal carcinoma 10.1 CXCL8 IL10
47 nasal cavity disease 10.1 IL10 IL5
48 acute pyelonephritis 10.1 CXCL8 IL10
49 pyelonephritis 10.1 CXCL8 IL10
50 keratoconjunctivitis 10.1 CCL17 CXCL8 IL5

Graphical network of the top 20 diseases related to Necatoriasis:



Diseases related to Necatoriasis

Symptoms & Phenotypes for Necatoriasis

Drugs & Therapeutics for Necatoriasis

Search Clinical Trials , NIH Clinical Center for Necatoriasis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: necatoriasis

Genetic Tests for Necatoriasis

Anatomical Context for Necatoriasis

MalaCards organs/tissues related to Necatoriasis:

41
Skin, Small Intestine, Lung, Bone, Prostate, Nk Cells

Publications for Necatoriasis

Articles related to Necatoriasis:

# Title Authors Year
1
The assessment of hookworm calreticulin as a potential vaccine for necatoriasis. ( 15910422 )
2005
2
Immune responses in human necatoriasis: association between interleukin-5 responses and resistance to reinfection. ( 15243914 )
2004
3
Epidemiology of human geohelminth infections (ascariasis, trichuriasis and necatoriasis) in Lushui and Puer Counties, Yunnan Province, China. ( 11288999 )
2000
4
Necatoriasis: treatment and developmental therapeutics. ( 11060728 )
2000
5
Parasitic infections. Treatment and developmental therapeutics. 1. Necatoriasis. ( 10438896 )
1999
6
Immunoepidemiology of human necatoriasis: correlations between antibody responses and parasite burdens. ( 7494644 )
1995
7
Evaluation of albendazole, pyrantel, bephenium, pyrantel-praziquantel and pyrantel-bephenium for single-dose mass treatment of necatoriasis. ( 2619378 )
1989
8
Course of egg output over a 15 year period in a case of experimentally induced necatoriasis americanus, in the absence of hyperinfection. ( 13238732 )
1955

Variations for Necatoriasis

Expression for Necatoriasis

Search GEO for disease gene expression data for Necatoriasis.

Pathways for Necatoriasis

Pathways related to Necatoriasis according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 CALR CCL22 CCL3 CCL4 CXCL8 IL10
2
Show member pathways
13.61 CCL17 CCL22 CCL3 CCL4 CXCL8 IL10
3
Show member pathways
13.44 CCL17 CCL22 CCL3 CCL4 CXCL8 IL10
4
Show member pathways
13.29 CCL17 CCL22 CCL3 CCL4 CXCL8 IL10
5
Show member pathways
13.19 CCL17 CCL22 CCL3 CCL4 CXCL8 IL10
6
Show member pathways
13.17 CCL17 CCL22 CCL3 CCL4 CXCL8
7
Show member pathways
13.13 CCL22 CCL3 CCL4 CXCL8 IL10 IL5
8
Show member pathways
13.09 CCL17 CCL22 CCL3 CCL4 CXCL8 IL10
9
Show member pathways
12.83 CALR CCL3 CCL4 CXCL8 IL10
10
Show member pathways
12.82 CALR CCL3 CCL4 CXCL8
11
Show member pathways
12.69 CALR CCL17 CCL22 CCL3 CCL4 CXCL8
12
Show member pathways
12.66 CALR CXCL8 IL10 IL5
13
Show member pathways
12.14 CCL17 CXCL8 IL5
14
Show member pathways
12.03 CCL17 CCL22 CCL3 CCL4 CXCL8
15
Show member pathways
12.02 CCL17 CCL22 IL10
16
Show member pathways
11.83 CCL17 CCL22 CCL3 CCL4 CXCL8
17 11.82 CCL22 CXCL8 IL10
18
Show member pathways
11.71 CCL17 CCL22 CCL3 CCL4 CXCL8 IL10
19 11.69 CCL3 CCL4 CXCL8
20 11.65 CCL3 IL10 IL5
21 11.53 CCL3 CCL4 CXCL8 IL5
22 11.51 CCL17 IL10 IL5
23 11.51 CCL17 CCL22 CCL3 CCL4 IL10
24 11.37 CCL17 CCL22 IL10 IL5
25 11.34 CXCL8 IL10
26 11.08 IL10 IL5
27 11.04 CCL22 CCL3 CCL4 CXCL8 IL10
28 11.03 IL10 IL5
29 10.77 CCL17 CCL22 CCL3 CCL4 CXCL8 IL10
30 10.4 CCL17 CCL22 CCL3 CCL4 CXCL8 IL10

GO Terms for Necatoriasis

Cellular components related to Necatoriasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular GO:0005622 9.63 CALR CCL3 CXCL8 DSTN EPGN IL5
2 extracellular region GO:0005576 9.61 CALR CCL17 CCL22 CCL3 CCL4 CXCL8
3 extracellular space GO:0005615 9.28 CALR CCL17 CCL22 CCL3 CCL4 CXCL8

Biological processes related to Necatoriasis according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.91 CCL17 CCL22 CCL3 CCL4 CXCL8 IL10
2 chemotaxis GO:0006935 9.89 CCL17 CCL22 CCL3 CCL4 CXCL8
3 cytokine-mediated signaling pathway GO:0019221 9.88 CCL22 CCL3 CCL4 CXCL8 IL10 IL5
4 positive regulation of GTPase activity GO:0043547 9.87 CCL17 CCL22 CCL3 CCL4
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.85 CCL17 CCL22 CCL3 CCL4
6 cellular response to tumor necrosis factor GO:0071356 9.85 CCL17 CCL22 CCL3 CCL4 CXCL8
7 cell-cell signaling GO:0007267 9.84 CCL17 CCL22 CCL3 CCL4
8 cellular response to interferon-gamma GO:0071346 9.81 CCL17 CCL22 CCL3 CCL4
9 MAPK cascade GO:0000165 9.8 CCL3 EPGN IL5
10 monocyte chemotaxis GO:0002548 9.78 CCL17 CCL22 CCL3 CCL4
11 lymphocyte chemotaxis GO:0048247 9.73 CCL17 CCL22 CCL3 CCL4
12 neutrophil chemotaxis GO:0030593 9.72 CCL17 CCL22 CCL3 CCL4 CXCL8
13 eosinophil chemotaxis GO:0048245 9.7 CCL22 CCL3 CCL4
14 regulation of signaling receptor activity GO:0010469 9.7 CCL17 CCL22 CCL3 CCL4 CXCL8 IL10
15 cellular response to interleukin-1 GO:0071347 9.65 CCL17 CCL22 CCL3 CCL4 CXCL8
16 regulation of sensory perception of pain GO:0051930 9.62 CCL3 IL10
17 positive regulation of calcium ion transport GO:0051928 9.61 CCL3 CCL4
18 leukocyte chemotaxis GO:0030595 9.6 CXCL8 IL10
19 positive regulation of calcium-mediated signaling GO:0050850 9.59 CCL3 CCL4
20 negative regulation by host of viral transcription GO:0043922 9.58 CCL3 CCL4
21 response to molecule of bacterial origin GO:0002237 9.58 CXCL8 IL10
22 positive regulation of natural killer cell chemotaxis GO:2000503 9.56 CCL3 CCL4
23 chemokine-mediated signaling pathway GO:0070098 9.35 CCL17 CCL22 CCL3 CCL4 CXCL8
24 inflammatory response GO:0006954 9.17 CCL17 CCL22 CCL3 CCL4 CXCL8 IL10
25 G protein-coupled receptor signaling pathway GO:0007186 10 CCL17 CCL22 CCL3 CCL4 CXCL8

Molecular functions related to Necatoriasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.54 EPGN IL10 IL5
2 CCR chemokine receptor binding GO:0048020 9.46 CCL17 CCL22 CCL3 CCL4
3 chemokine activity GO:0008009 9.35 CCL17 CCL22 CCL3 CCL4 CXCL8
4 CCR5 chemokine receptor binding GO:0031730 9.32 CCL3 CCL4
5 CCR1 chemokine receptor binding GO:0031726 9.26 CCL3 CCL4
6 cytokine activity GO:0005125 9.17 CCL17 CCL22 CCL3 CCL4 CXCL8 IL10

Sources for Necatoriasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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